Hub : Genes

ABCA12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.06 0.029 1.7e-02 0.012 0.010 0.006 0.012 0.005 1.1e-02 2.1e-02 4.9e-02 1.3e-02 7.9e-02
2 TCGA Breast Tumor 0.17 0.074 9.1e-03 0.015 -0.012 -0.013 NA -0.006 1.4e-01 7.5e-01 8.8e-01 NA 4.7e-01
3 TCGA Breast Normal 0.07 0.017 1.0e-09 0.035 0.031 0.044 0.037 0.044 1.1e-09 7.9e-09 6.1e-12 3.1e-10 8.2e-12
4 TCGA Ovarian Tumor 0.21 0.052 1.9e-12 0.115 0.128 0.133 NA 0.153 2.2e-11 1.4e-12 5.0e-13 NA 7.4e-15

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Alzheimer’s Disease (in mother) 0.3 0.4 1.3 -1.2 0.1 -0.1 0.3
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.5 -0.4 0.6 -0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 1.0 -1.0 -0.2 0.1 0.2
Crohns Disease (2017) 0.6 1.3 2.6 -1.0 1.0 0.8 -1.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.8 -1.3 0.3 -0.4 -0.8
Ulcerative Colitis (UC) 0.5 1.0 2.0 -1.3 -0.4 -1.4 -0.2
Major Depression (MDD) 2.3 2.8 7.1 1.0 2.7 1.7 -0.5
Reaction Time 0.3 0.6 1.5 0.8 -1.2 0.6 0.3
Verbal and Numeric Reasoning (VNR) 0.9 2.1 6.2 0.6 0.1 -1.4 2.5
Breast Cancer 0.3 0.8 1.5 -1.2 0.6 -1.1 -0.6
Ovarian Cancer 1.0 1.3 2.8 1.3 -0.7 -1.7 0.4
Prostate Cancer 0.6 0.9 1.5 0.6 0.7 1.2 1.1
Age at First Birth 0.9 1.4 2.9 1.4 -0.8 -0.2 1.7
Bipolar Disorder 1.2 1.2 1.9 1.4 0.1 1.1 1.3
Body Mass Index (BMI) (2010) 0.0 0.1 0.1 -0.3 0.2 0.1 0.4
Coronary Artery Disease (CAD) 3.1 3.8 10.3 0.1 -3.2 -2.2 0.3
Crohns Disease (2012) 0.2 0.4 1.5 0.1 -0.2 0.1 1.2
Mean Putamen Volume 1.8 2.1 3.0 1.6 -1.7 -1.6 0.6
Fasting Glucose 0.5 0.5 1.2 -0.2 -0.8 -1.1 -0.5
HbA1C 0.5 0.6 1.7 0.0 0.3 0.8 1.3
HDL Cholesterol 0.2 0.4 1.0 -0.3 0.5 0.4 1.0
LDL Cholesterol 1.2 1.9 3.7 1.5 1.3 1.9 -0.1
Lupus 0.8 1.2 3.9 -0.1 -0.5 -0.8 2.0
Neuroticism 1.4 2.1 6.1 1.0 2.5 0.3 -1.1
Primary Biliary Cirrhosis 0.3 0.4 1.3 -0.1 -1.1 -0.5 0.3
Rheumatoid Arthritis 0.9 1.2 2.4 1.6 -0.8 0.7 1.1
Schizophrenia 0.5 1.0 2.2 1.5 -0.8 0.1 1.2
Triglycerides 0.8 1.3 2.2 -0.7 0.5 1.5 -1.5
Type 2 Diabetes (T2D) 1.1 1.3 3.4 1.8 -1.0 -0.7 -0.6
Ulcerative Colitis 0.4 0.6 1.5 1.2 -0.4 0.9 0.2
Blood Eosinophil Count 0.1 1.1 2.5 0.1 -0.3 1.4 1.6
Blood Platelet Count 0.3 3.9 6.8 -2.0 -2.6 -1.9 -1.1
Blood Red Count 0.1 0.8 2.0 -1.4 -0.1 1.0 0.2
Blood White Count 0.8 5.8 18.0 -4.2 -1.1 0.7 -1.8
Heel T-Score 0.4 3.4 5.4 2.3 -1.8 2.2 0.2
BMI 0.2 1.3 1.8 -1.3 1.3 0.2 -1.4
Height 0.1 1.5 3.9 -0.6 1.3 0.1 2.0
Waist Hip Ratio (WHR) 0.9 4.3 13.2 -3.6 -0.7 -1.8 -0.1
Systolic Blood Pressure 2.1 10.9 39.6 -6.3 0.3 -1.8 -0.8
Smoking Status 0.4 1.1 4.3 0.0 -2.1 0.2 -0.1
Allergy or Eczema 0.2 0.4 1.4 -0.3 1.2 -0.2 0.5
Cardiovascular Disease 1.3 4.2 9.4 -3.1 2.2 1.6 -0.5
Hypothyroidism (self reported) 0.4 0.9 1.8 -0.8 1.3 -0.3 1.0
Respiratory disease 1.8 4.0 12.2 -1.5 3.5 1.1 0.7
Type 2 Diabetes (T2D) 0.8 1.4 2.7 -0.6 1.6 1.4 -0.8
Lung FEV1/FVC ratio 0.0 0.2 0.8 -0.9 0.1 -0.1 0.2
Lung FVC 1.0 5.4 15.4 3.9 0.9 -0.2 2.3
Neuroticism 3.3 8.2 28.7 0.4 5.4 1.4 -1.3
Chronotype (morning person) 1.3 3.0 5.5 2.3 -0.1 1.2 2.2
Hair Pigment 0.0 0.2 0.4 -0.6 0.0 -0.4 0.2
Tanning 0.1 1.8 3.8 -1.9 -0.7 0.4 -1.7
Hand grip strength (left) 1.5 4.1 12.5 -3.5 0.2 -1.2 -1.5
Number of treatments/medications taken 1.8 3.2 5.2 2.3 -1.9 -0.7 1.9
Average weekly spirits intake 1.0 1.2 3.0 -0.9 -1.7 -1.0 0.4
Sensitivity / hurt feelings 1.2 2.1 7.4 0.6 -2.7 -0.5 0.5
Frequency of depressed mood in last 2 weeks 1.1 1.5 5.0 -0.0 -2.2 -0.6 0.9
Hearing difficulty/problems: Yes 1.2 1.9 3.5 -0.3 -1.2 1.9 1.6
Relative age of first facial hair 0.3 0.6 1.5 -0.4 1.2 0.8 -0.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.3 0.3 -0.0 0.3 1.2
Ever used hormone-replacement therapy (HRT) 2.4 3.1 10.2 1.2 -0.4 -0.7 3.2
Ever had hysterectomy (womb removed) 1.1 1.3 2.0 1.4 -0.1 1.2 1.2
Systolic blood pressure, automated reading 2.7 8.0 23.9 4.9 0.7 1.7 2.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 -0.8 -1.3 -0.4 0.4
Angina 1.0 1.3 4.0 2.0 0.7 0.3 0.8
Medication for hormone replacement therapy 0.4 0.4 0.9 -0.7 0.1 0.6 0.9
Vitamin and mineral supplements 1.3 1.7 4.0 0.7 -2.0 -0.7 1.4
Supplements: Zinc 0.9 0.9 2.3 0.9 -0.7 1.5 -0.3
Medication: Co-codamol 0.8 0.9 3.1 1.7 0.5 -0.4 0.2
Medication: Metformin 1.8 2.5 4.0 1.3 -1.7 -1.2 2.0
Diabetes (father) 0.7 0.9 2.0 -1.4 0.0 0.1 1.2
Diabetes (mother) 0.7 0.9 3.1 0.5 0.3 -0.1 1.8
Severe depression (siblings) 1.0 1.1 3.0 0.7 -0.9 -1.7 0.1
Pack years adult smoking proportion 0.5 0.7 2.9 0.1 -0.3 0.1 -1.7
Impedance of leg (right) 0.3 1.3 4.5 0.3 2.1 -0.5 -0.5
Leg fat-free mass (left) 0.5 2.7 8.6 -1.1 -2.9 -0.0 -1.0
Trunk fat percentage 0.6 2.3 5.0 1.9 -0.8 0.2 2.2
Hand grip strength (right) 0.8 2.1 5.7 -2.4 0.2 -1.5 -0.7
Townsend deprivation index at recruitment 1.9 2.8 7.0 0.3 -1.2 -2.6 1.6
Current tobacco smoking 0.4 0.7 2.2 -0.5 1.5 -0.1 -0.5
Average weekly fortified wine intake 0.7 0.9 2.7 0.6 0.6 -0.1 1.6
Maternal smoking around birth 0.7 1.0 3.7 -0.2 0.5 1.9 -0.2
Fed-up feelings 4.5 8.3 19.6 1.1 -4.4 -0.4 3.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.2 0.1 -1.0 -0.0 1.1
Relative age voice broke 0.3 0.5 1.8 0.2 0.3 1.3 0.1
Taking other prescription medications 0.3 0.5 1.2 0.2 -1.1 0.4 0.7
Age when periods started (menarche) 1.4 3.4 6.4 -1.8 2.5 1.5 -1.4
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 6.1 2.5 0.1 -0.2 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.3 0.5 1.1 -0.3 -0.1
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 4.2 -1.2 0.2 0.4 -2.0
Qualifications: CSEs or equivalent 0.6 0.8 1.5 1.2 -0.6 0.7 0.8
Serious illness, injury or assault to yourself 0.8 1.0 1.7 -0.8 -1.1 -1.3 0.8
High blood pressure 2.6 7.3 22.3 4.7 -1.7 0.3 1.9
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.8 0.1 -0.3 0.9 -0.9
Multivitamins +/- minerals 0.4 0.5 0.8 0.6 0.7 0.6 -0.9
Stomach or abdominal pain in last month 1.3 1.7 4.1 -0.6 0.7 2.0 1.3
Supplements: Glucosamine 0.8 1.0 3.0 -0.9 -0.3 0.2 -1.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.8 0.2 0.0 0.1 0.9
Medication: Atenolol 0.4 0.5 1.7 1.3 -0.3 0.1 -0.1
Medication: Levothyroxine sodium 1.3 2.2 4.6 2.2 -0.2 2.0 0.3
Sitting height 0.6 4.5 9.8 -3.1 -2.0 -0.5 -2.0
Chronic bronchitis/emphysema (father) 1.7 2.0 3.4 1.8 -1.4 -0.0 1.6
High blood pressure (mother) 2.3 3.2 7.0 2.6 1.4 2.0 0.2
Body mass index (BMI) 0.4 1.6 3.9 1.1 -2.0 0.0 1.1
Impedance of leg (left) 0.2 1.2 4.2 0.8 2.0 -0.2 0.2
Leg predicted mass (left) 0.5 2.5 7.8 -1.1 -2.8 0.0 -0.9
Trunk fat mass 0.4 1.8 3.3 1.3 -1.8 0.3 1.4
Waist circumference 0.5 2.0 3.8 2.0 -1.6 1.1 0.5
Number of incorrect matches in round 1.7 2.8 7.5 1.2 1.4 0.4 2.7
Past tobacco smoking 0.3 0.7 1.3 -1.0 -0.6 1.1 -0.0
Alcohol usually taken with meals 0.4 0.6 1.4 -1.1 1.2 0.2 0.1
Nervous feelings 0.7 1.3 1.8 -1.4 -0.7 1.1 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 2.3 -0.5 -1.5 0.5 1.2
Hearing difficulty/problems with background noise 0.7 1.1 3.6 0.3 -0.8 -0.1 1.9
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 0.3 -0.1 -0.1 0.0
Had menopause 0.8 1.0 2.2 0.4 1.5 0.4 1.3
Had other major operations 0.4 0.5 1.7 0.4 0.4 0.2 1.3
Forced vital capacity (FVC) 2.2 8.6 15.0 -3.9 -2.3 -0.4 -3.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 3.5 -0.0 1.9 -0.2 -0.3
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.6 -1.4 -1.6 -2.1 0.5
Qualifications: None of the above 1.9 4.1 14.3 1.2 -0.3 -0.6 3.8
Financial difficulties in last 2 years 2.1 2.9 6.7 2.6 -0.5 -0.2 2.1
Mouth/teeth dental problems 0.8 1.3 3.2 -1.3 1.8 0.4 -0.1
Heart attack 1.1 1.5 2.9 1.7 0.7 0.4 1.5
Allergy 0.2 0.4 0.5 -0.7 0.7 -0.7 0.4
Pain all over the body in last month 0.2 0.2 0.3 -0.1 -0.1 0.6 -0.5
Diabetes (self-reported) 1.3 2.0 3.3 1.5 -1.2 -1.1 1.8
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.7 -1.0 -0.4 -1.3 0.6
Medication: Ramipril 1.3 1.6 3.2 1.8 0.3 1.5 1.0
Medication: Simvastatin 1.8 2.7 5.4 2.2 0.5 -0.3 2.3
Fluid intelligence score 1.4 3.0 7.3 -1.1 -0.1 1.8 -2.7
Illnesses of siblings 1.4 2.0 3.2 -1.8 0.9 1.2 -1.6
Neuroticism score 2.8 5.9 20.2 -0.1 -4.5 -1.3 1.3
Weight 0.4 1.9 7.5 0.3 -2.7 -0.1 -0.0
Impedance of arm (right) 0.5 2.4 6.6 1.1 2.6 0.4 1.4
Arm fat percentage (right) 0.7 2.7 6.1 1.9 -0.9 0.6 2.5
Trunk fat-free mass 0.9 5.0 10.2 -2.0 -3.2 -0.3 -2.4
Hip circumference 0.6 2.5 9.2 -0.4 -3.0 -0.4 -0.7
Time employed in main current job 0.2 0.2 0.6 0.1 0.4 0.4 -0.8
Alcohol intake versus 10 years previously 1.4 2.2 3.9 1.3 -2.0 -0.6 1.6
Father’s age at death 0.4 0.5 1.6 -1.3 0.8 -0.1 -0.1
Worrier / anxious feelings 0.5 1.0 4.0 -0.0 -2.0 0.4 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 4.0 -0.8 -2.0 0.0 0.6
Falls in the last year 0.4 0.5 1.3 0.2 -1.1 0.2 0.9
Hair/balding pattern: Pattern 3 0.1 0.2 0.8 0.2 -0.2 -0.2 0.9
Number of live births 2.5 3.6 7.0 1.3 2.3 -0.2 2.6
Forced expiratory volume in 1-second (FEV1) 2.0 6.9 15.2 -3.9 -1.9 -0.5 -2.9
Pulse rate 1.6 2.7 3.4 1.5 -1.8 -1.7 1.5
Happiness 0.8 0.9 2.2 -0.6 -1.5 -0.8 0.7
Noisy workplace 0.4 0.5 1.3 0.3 -0.5 -0.7 1.1
Qualifications: A levels/AS levels or equivalent 0.9 2.1 4.8 -2.2 0.2 1.0 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.2 -1.1 -0.7 -0.8 0.6
Mouth/teeth dental problems: Dentures 0.8 1.4 3.0 1.7 -0.9 -0.2 1.4
Asthma 1.3 2.6 4.4 2.0 -2.1 -1.3 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.9 3.2 1.6 -1.3 -1.8 -0.2
Medication: Cholesterol lowering 0.3 0.5 1.1 0.7 -0.0 -0.6 1.0
Depression (self-reported) 0.1 0.1 0.3 0.2 -0.5 0.2 -0.2
Medication: Lansoprazole 0.8 0.9 3.2 -1.8 0.1 0.3 0.5
Prospective memory result 2.6 3.1 8.1 -2.9 -0.1 -1.8 -1.0
Lung cancer (father) 1.3 1.5 3.9 -2.0 -0.5 -0.9 -1.0
Illnesses of mother 2.7 3.4 7.0 -2.6 -2.0 -1.2 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 6.9 -2.6 -2.0 0.2 -2.1
Pulse wave Arterial Stiffness index 0.3 0.4 0.9 -0.1 0.6 0.9 -0.6
Impedance of arm (left) 0.6 2.8 8.4 0.9 2.9 1.2 0.8
Arm fat mass (right) 0.4 1.6 3.5 1.1 -1.9 0.2 1.3
Trunk predicted mass 0.8 4.8 9.5 -2.0 -3.1 -0.3 -2.3
Standing height 0.3 3.4 7.2 -1.8 -1.8 -0.2 -2.7
Length of working week for main job 0.5 0.5 1.6 -0.4 0.6 1.2 0.3
Exposure to tobacco smoke at home 0.7 0.8 1.6 0.8 0.7 -1.3 0.7
Breastfed as a baby 1.0 1.2 3.0 -1.7 1.1 0.1 -0.7
Tense / ‘highly strung’ 2.1 3.6 12.7 -0.3 -3.6 -1.2 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.8 4.3 1.4 -2.1 -1.6 1.6
Hair/balding pattern: Pattern 4 0.5 1.2 2.8 -0.5 -0.9 -1.7 -0.9
Birth weight of first child 1.0 1.8 3.5 1.9 -1.7 -0.9 -0.2
Peak expiratory flow (PEF) 3.0 7.1 20.6 -4.5 -1.5 -0.8 -2.3
Pulse wave reflection index 1.7 2.1 3.5 -1.2 1.7 1.9 0.5
Ever highly irritable/argumentative for 2 days 1.9 2.3 4.9 -0.5 -1.3 -2.2 1.5
Loud music exposure frequency 2.3 2.6 5.7 -0.9 -1.9 0.3 -2.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.7 0.1 0.6 1.3 -1.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.9 1.4 -0.1 0.9 0.3
Blood clot in the leg (DVT) 0.2 0.2 0.6 0.0 -0.8 0.5 -0.2
Medication: Paracetamol 1.7 2.8 8.7 0.9 -2.9 -1.4 0.1
Headache pain in last month 0.4 0.8 2.5 0.4 -1.6 -0.7 0.0
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 4.7 -2.2 1.5 0.3 -1.5
Glaucoma (self-reported) 0.3 0.4 0.6 -0.5 0.8 -0.3 0.8
Gout (self-reported) 1.1 1.5 5.4 -0.2 0.2 0.7 -2.3
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.6 1.1 -1.3 0.7 -0.3
Medication: Amlodipine 1.4 2.0 4.7 2.2 -1.6 -0.4 0.6
Medication: Ventolin 100micrograms inhaler 1.0 1.2 4.0 -0.8 0.3 -2.0 -0.5
Birth weight 0.4 0.8 2.4 0.6 -1.6 -0.7 0.2
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.3 -0.1 0.9 -0.7 1.5
High blood pressure (siblings) 0.3 0.5 1.7 1.3 -0.4 0.2 -0.0
Forced vital capacity (FVC), Best measure 1.6 5.8 9.5 -2.9 -2.3 0.2 -3.1
Body fat percentage 0.6 2.5 4.9 2.0 -1.0 0.2 2.2
Leg fat percentage (right) 0.5 1.7 3.4 1.8 -1.3 -0.1 1.3
Arm fat-free mass (right) 0.8 4.3 11.8 -1.3 -3.4 -0.5 -1.9
Exposure to tobacco smoke outside home 1.3 1.7 4.2 1.3 0.4 -0.8 2.0
Comparative body size at age 10 0.2 0.6 1.3 -0.2 1.2 -1.0 -0.0
Number of full brothers 2.3 3.0 6.6 1.9 0.1 -1.2 2.6
Worry too long after embarrassment 0.7 1.3 4.1 -0.4 -2.0 -0.8 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 3.7 -0.2 -1.6 -1.9 0.5
Wheeze or whistling in the chest in last year 1.0 1.8 3.2 1.0 -1.8 -1.8 -0.1
Number of children fathered 0.6 0.7 1.5 0.6 1.2 0.3 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.7 0.3 -0.8 0.0 -0.8
Age at first live birth 7.3 13.2 28.4 -3.6 0.4 3.3 -5.3
Pulse wave peak to peak time 0.4 0.4 0.8 0.2 -0.9 -0.8 0.4
Health satisfaction 0.4 0.6 0.9 -0.3 -0.9 -1.0 0.7
Shortness of breath walking on level ground 0.4 0.5 0.9 0.7 0.3 -0.6 0.9
Qualifications: College or University degree 1.2 3.8 8.9 -2.4 -0.3 0.7 -3.0
Eye problems/disorders: None of the above 0.6 0.7 2.0 -0.0 1.4 0.7 -0.3
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.6 0.6 -1.3 -0.9 1.6
Emphysema/chronic bronchitis 0.6 0.7 2.0 -1.4 -0.5 -0.2 -0.8
Medication for pain relief, constipation, heartburn 1.2 2.0 3.4 -1.8 1.4 1.4 -0.8
Neck or shoulder pain in last month 0.2 0.3 0.7 0.2 -0.5 0.2 0.8
Medication: Blood pressure 1.3 2.2 4.8 2.2 -1.9 0.4 0.6
Angina (self-reported) 0.7 0.9 3.0 1.7 0.6 0.2 0.4
Migraine (self-reported) 0.3 0.3 0.7 -0.8 -0.1 -0.1 -0.8
Medication: Ibuprofen 1.3 1.5 3.2 1.0 -1.3 -1.8 -0.4
Medication: Allopurinol 1.5 2.0 5.8 -0.1 0.5 1.4 -2.4
Medication: Omeprazole 0.7 0.9 1.6 -0.5 -1.1 -1.3 0.7
Medication: Seretide 50 evohaler 0.9 1.1 3.6 -1.9 -0.7 -0.5 0.1
Mean time to correctly identify matches 0.6 1.1 1.8 0.4 1.2 -1.3 0.9
Heart disease (mother) 3.2 4.0 10.4 3.2 -0.8 -1.3 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.9 -0.6 0.1 -1.4 -0.3
Whole body fat mass 0.4 1.9 3.5 1.4 -1.9 0.5 1.3
Leg fat mass (right) 0.4 1.5 4.1 1.0 -2.0 0.1 0.9
Arm predicted mass (right) 0.8 4.1 10.6 -1.5 -3.2 -0.5 -1.8
Pulse rate, automated reading 0.9 3.0 4.1 1.7 -2.0 -1.4 1.8
Alcohol intake frequency. 1.1 2.7 9.5 1.0 -0.5 -0.1 3.1
Comparative height size at age 10 0.0 0.2 0.5 0.2 -0.7 -0.4 0.1
Number of full sisters 0.5 0.6 1.0 -0.9 1.0 -0.6 0.7
Suffer from ‘nerves’ 2.2 3.4 11.4 -0.3 -3.4 -0.9 1.2
Overall health rating 0.6 1.4 4.1 0.4 -2.0 -0.4 1.1
Chest pain or discomfort 0.9 1.3 4.2 2.1 -0.7 -0.6 -0.3
Had major operations 0.3 0.3 0.7 -0.8 0.1 0.7 -0.3
Age at last live birth 3.5 5.1 10.3 -1.4 0.8 2.8 -3.2
Family relationship satisfaction 3.3 4.1 11.3 0.6 -3.4 -2.2 0.0
Leg pain on walking 1.8 2.2 4.5 -1.0 -1.7 -0.6 2.1
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.8 0.3 -1.3 -1.3 1.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.9 0.2 1.0 0.0 -1.4
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 7.8 -0.8 -0.0 0.9 -2.8
Medication: Aspirin 1.3 1.7 3.1 1.7 0.9 0.3 1.8
Supplements: Vitamin C 2.1 2.5 6.3 -2.5 1.6 0.3 -1.0
Knee pain experienced in last month 0.3 0.5 1.3 -0.2 -0.7 -0.1 1.1
Hypertension (Self-reported) 2.6 7.2 21.4 4.6 -2.2 -0.1 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.2 -0.3 -1.5 0.1 0.7
Illnesses of father: Heart disease 1.5 2.1 6.4 2.5 -0.9 0.1 1.0
Illnesses of siblings: Diabetes 1.4 1.7 5.7 0.9 -0.2 -0.4 2.4
Smoking status: Previous 0.5 0.8 1.4 1.1 1.2 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.7 -0.6 -0.9 0.2 0.5
Whole body fat-free mass 0.7 4.0 10.2 -1.5 -3.2 -0.2 -1.8
Leg fat-free mass (right) 0.4 2.4 8.2 -0.9 -2.9 0.1 -0.8
Arm fat percentage (left) 0.6 2.4 4.6 1.8 -0.8 1.0 2.1
Average weekly red wine intake 0.8 1.3 4.1 -0.5 2.0 -0.0 0.8
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.0 0.7 -0.1 0.4 1.7
Mood swings 2.5 4.5 9.9 0.4 -2.6 -1.2 3.1
Loneliness, isolation 2.3 3.2 10.3 0.1 -3.2 -0.5 1.5
Long-standing illness, disability or infirmity 1.4 2.1 4.9 0.7 -2.2 -0.8 1.5
Ever had bowel cancer screening 1.4 1.7 3.9 1.1 2.0 1.2 -0.2
Diabetes diagnosed by doctor 1.3 2.1 3.4 1.4 -1.3 -1.2 1.8
Ever had stillbirth, spontaneous miscarriage or termination 3.5 3.8 7.0 -2.6 2.6 -0.6 -1.1
Friendships satisfaction 0.4 0.6 1.3 -0.4 -0.9 0.2 1.1
Qualifications: nursing, teaching 0.3 0.5 1.7 -1.3 0.4 0.4 -0.4
Commuting to job workplace: Walk 1.3 1.4 2.9 -1.7 -0.4 -0.7 -1.4
Eye problems/disorders: Cataract 0.3 0.3 0.8 -0.9 -0.2 -0.2 0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.8 0.7 -1.7 -0.2 -0.0
Medication for cholesterol 3.3 5.0 13.2 -3.6 0.1 -0.0 -2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.7 -1.6 0.4 -0.7 -0.1
Back pain experienced in last month 0.4 0.6 1.7 0.7 -1.3 0.3 -0.0
Mineral and other dietary supplements 0.8 1.1 3.5 0.2 0.5 0.7 1.9
Breast cancer (self-reported) 1.2 1.4 5.0 -0.0 -0.5 -2.2 0.5
Asthma (self-reported) 1.0 2.0 3.3 1.7 -1.8 -1.4 -0.1
Osteoporosis (self-reported) 2.0 2.5 5.8 -2.0 0.4 0.0 2.4
Osteoarthritis (self-reported) 0.8 1.0 2.0 0.4 0.6 1.4 1.3
Medication: Aspirin 1.1 1.4 3.0 1.4 0.8 -0.1 1.7
Medication: Gliclazide 1.0 1.2 2.1 0.6 0.5 1.5 1.4
Illnesses of father: None of the above (group 1) 3.0 3.6 9.0 -3.0 0.2 0.3 -2.3
Smoking status: Current 0.4 0.7 2.6 -0.4 1.6 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 5.1 -2.3 0.0 -0.2 -2.0
Whole body water mass 0.7 4.2 11.2 -1.5 -3.3 -0.3 -1.8
Leg predicted mass (right) 0.5 2.6 8.9 -0.9 -3.0 0.1 -0.8
Arm fat mass (left) 0.5 1.9 3.6 1.4 -1.9 0.6 1.3
Number of self-reported non-cancer illnesses 1.2 2.1 3.8 2.0 -0.6 0.8 1.8
Average weekly champagne plus white wine intake 1.4 2.0 3.9 -2.0 1.8 0.7 -0.5
Miserableness 3.4 5.9 13.5 1.5 -3.7 -1.8 2.1
Guilty feelings 2.2 3.4 7.7 -1.1 -2.8 -2.0 0.8
Wears glasses or contact lenses 0.3 0.3 0.9 1.0 -0.3 0.5 -0.3
Ever taken oral contraceptive pill 0.5 0.6 1.1 1.0 -0.9 -0.4 0.4
Hearing aid user 0.5 0.6 1.7 -0.4 -1.3 0.4 -0.4
Mother’s age at death 0.6 0.8 2.4 -1.5 0.6 -0.2 -0.6
Financial situation satisfaction 1.3 1.7 4.0 1.2 0.4 1.0 2.0
Tinnitus: Yes, now most or all of the time 1.5 1.7 4.3 -2.1 1.4 0.8 0.1
Commuting to job workplace: Public transport 0.8 1.0 2.3 0.1 -1.5 0.3 1.2
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.4 0.3 -0.5 0.1
Medication: Blood pressure 4.0 7.7 28.0 5.3 -0.5 0.2 1.6
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.4 -0.9 0.3 0.2 1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.2 0.5 0.7 -0.0 -1.5
High cholesterol (Self-reported) 1.4 2.4 4.4 1.8 2.1 0.4 1.3
Medication: Bendroflumethiazide 1.3 1.9 6.5 2.5 0.4 0.8 0.6
Medication: Paracetamol 2.4 3.8 11.8 0.3 -3.4 -1.7 -0.5
Medication: Lisinopril 0.2 0.3 1.1 1.1 0.1 0.3 0.1
Medication: Atorvastatin 0.2 0.2 0.5 0.3 0.7 -0.3 0.5
Illnesses of father: High blood pressure 0.5 0.6 1.2 0.6 0.5 1.1 -0.7
Alcohol drinker status: Never 0.7 0.9 1.7 1.3 -1.0 -0.0 0.9
Ever smoked 0.5 0.9 2.9 0.6 -0.2 -1.7 0.4
Basal metabolic rate 0.6 3.4 10.2 -1.2 -3.2 -0.2 -1.4
Leg fat percentage (left) 0.6 2.0 3.9 2.0 -1.4 0.1 1.5
Arm fat-free mass (left) 0.6 3.3 9.4 -1.1 -3.1 -0.3 -1.6
Number of operations (self-reported) 0.3 0.5 1.1 -0.6 0.5 1.0 0.6
Average weekly beer plus cider intake 0.8 1.2 2.4 -0.6 -1.6 -1.1 -0.9
Irritability 1.3 2.3 7.8 -1.0 -2.8 -0.3 -0.5
Risk taking 1.9 2.7 4.7 -0.3 2.1 -1.4 2.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.5 -0.9 -1.2 -0.5 -0.5
Fractured/broken bones in last 5 years 0.5 0.6 1.8 0.7 -0.3 -1.3 0.2
Age started oral contraceptive pill 0.6 0.8 2.5 -0.4 -1.6 0.6 0.3
Diastolic blood pressure, automated reading 0.7 2.1 5.3 2.3 -0.8 -0.2 1.5
Ever depressed for a whole week 4.3 5.3 13.6 -0.0 -2.4 -3.7 1.4
Unable to work because of sickness or disability 1.5 2.0 3.3 -1.8 1.8 1.2 -0.3
Commuting to job workplace: Cycle 1.4 1.7 4.4 -1.0 2.1 0.2 -1.2
Myopia 1.1 1.6 3.7 -0.9 -1.9 -0.3 -1.3
Vascular/heart problems diagnosed by doctor 2.5 6.9 22.8 -4.8 1.5 -0.6 -1.6
Cholesterol lowering medication 2.7 4.0 8.6 2.9 0.8 0.0 2.6
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.3 -1.0 -0.8 -0.7 1.1
Pain experienced in last month 0.5 0.9 2.1 0.7 0.9 -0.3 -1.4
Supplements: Calcium 1.9 2.0 6.9 -2.6 0.0 -1.0 -0.4
Basal cell carcinoma (self-reported) 0.7 0.8 3.1 0.3 -1.8 -0.2 0.3
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.5 1.6 1.0 0.5 1.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 0.1 -0.5 0.9 0.1
Heart disease (siblings) 3.1 3.8 7.5 2.7 -2.1 -1.3 1.3
Alcohol drinker status: Previous 1.2 1.4 3.3 -0.4 1.3 0.3 1.8
Pack years of smoking 0.3 0.4 1.4 0.3 0.1 0.1 -1.2
Impedance of whole body 0.5 2.5 7.8 1.1 2.8 0.5 0.8
Leg fat mass (left) 0.4 1.7 4.6 1.1 -2.1 0.2 1.0
Arm predicted mass (left) 0.7 3.7 11.3 -0.9 -3.4 -0.6 -1.6