Hub : Genes

ABCA8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0270	7.8e-05	0.049	0.009	0.060	0.042	0.070	1.1e-06	2.7e-02	8.1e-08	6.2e-06	7.5e-09
2	GTEx	Cells Transformed fibroblasts	0.2440	0.0490	1.1e-09	0.148	NA	0.193	NA	0.105	3.4e-11	NA	1.9e-14	NA	3.0e-08
3	GTEx	Esophagus Mucosa	0.1940	0.0620	5.7e-04	-0.003	NA	0.054	NA	0.004	6.1e-01	NA	1.6e-04	NA	1.7e-01
4	GTEx	Nerve Tibial	0.1296	0.0481	2.8e-03	0.016	NA	0.034	NA	0.025	2.4e-02	NA	1.7e-03	NA	6.3e-03
5	GTEx	Skin Sun Exposed Lower leg	0.1100	0.0370	5.4e-04	0.009	NA	0.020	NA	0.002	5.8e-02	NA	8.5e-03	NA	2.1e-01
6	GTEx	Testis	0.2960	0.0660	8.0e-07	0.200	NA	0.180	NA	0.101	3.0e-09	NA	2.0e-08	NA	3.3e-05
7	TCGA	Bladder Urothelial Carcinoma	0.1250	0.0610	9.7e-04	0.003	0.049	0.043	NA	0.032	1.8e-01	5.0e-05	1.5e-04	NA	8.9e-04
8	TCGA	Breast Invasive Carcinoma	0.0323	0.0148	1.1e-05	0.004	0.029	0.026	NA	0.028	4.4e-02	1.1e-06	4.3e-06	NA	1.4e-06
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0390	0.0193	6.1e-04	0.007	0.022	0.007	NA	0.015	5.3e-02	1.4e-03	4.6e-02	NA	7.2e-03
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0575	0.0301	1.9e-04	0.025	0.040	0.032	NA	0.024	6.9e-04	2.4e-05	1.6e-04	NA	9.9e-04
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.1410	0.0740	4.0e-03	-0.004	0.012	0.001	NA	-0.003	8.8e-01	4.8e-02	2.5e-01	NA	5.7e-01
12	TCGA	Prostate Adenocarcinoma	0.0502	0.0235	2.2e-05	0.059	0.049	0.039	NA	0.050	8.0e-07	7.4e-06	5.3e-05	NA	6.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.9	3.0	7.3	2.7	-1.4	-0.2	2.2	-1.0	-0.4	-0.3	-2.4	-1.9	-2.2	-1.9	-1.5
Bipolar Disorder or Schizophrenia	0.4	1.1	3.6	1.9	0.1	1.0	1.9	-0.3	1.2	0.3	-0.6	0.1	-1.1	-0.2	-1.2
Depressed Affect (Nagel 2018)	0.3	0.7	2.9	0.7	-0.8	1.7	1.0	0.4	-0.1	-0.8	-0.6	-0.2	-0.6	1.1	0.4
Depression (Nagel 2018)	0.5	0.8	3.1	0.4	-0.6	1.0	-0.6	0.7	-0.8	-1.8	-1.2	-1.1	-0.8	0.0	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.2	-2.1	-0.1	0.7	-0.2	-0.3	0.8	2.0	0.5	0.7	-1.0	1.8	-0.9
Neuroticism (Nagel 2018)	0.4	1.0	6.8	0.8	-0.6	2.6	0.7	0.4	0.4	-1.3	-0.8	-0.3	-0.7	0.9	-0.1
Schizophrenia (2018)	0.6	1.2	3.8	0.2	1.2	1.5	0.6	0.3	1.9	0.6	1.2	1.7	0.3	1.3	-0.4
Schizophrenia vs Biploar Disorder	3.2	4.2	10.2	-1.9	2.3	3.2	-2.1	2.2	1.9	1.4	2.4	2.1	1.2	1.9	0.7
Worry (Nagel 2018)	0.7	1.4	8.6	-0.1	-0.6	2.9	-0.4	-0.4	-0.1	-0.9	-1.2	-0.9	-1.6	1.1	-0.7
Alzheimer’s Disease (in mother)	1.2	1.5	4.0	-0.2	-1.6	-0.2	-0.6	-1.6	-2.0	1.5	-1.2	-1.1	-1.3	-1.2	0.3
Alzheimer’s Disease (in father)	0.5	0.5	2.4	-1.4	-0.4	0.0	-1.5	-0.2	-0.7	0.5	-0.0	-0.8	-0.7	-0.2	-0.4
Alzheimer’s Disease (including proxy)	1.0	1.4	2.8	-1.3	-1.2	0.1	-1.6	-1.3	-1.7	1.3	-0.5	-1.4	-1.5	-0.5	-0.5
Crohns Disease (2017)	0.4	0.8	1.8	1.1	-1.0	0.8	0.2	-1.1	-0.5	-1.3	-0.9	-0.9	-0.6	-0.9	-0.7
Irritable Bowel Disease (IBD)	0.5	1.1	3.5	0.9	-0.7	-0.8	-0.3	-1.1	0.6	-1.7	-1.0	-1.1	-1.1	-0.6	-1.9
Ulcerative Colitis (UC)	0.7	1.2	4.4	-0.2	-0.4	-2.0	-0.6	-1.1	1.0	-1.2	-0.7	-0.8	-1.2	0.1	-2.1
Major Depression (MDD)	1.9	2.3	7.5	-0.8	-1.5	-1.3	-0.9	-1.1	-1.5	-0.3	-2.0	-2.1	-2.7	-0.1	-1.8
Reaction Time	0.1	0.3	0.9	-0.3	0.0	0.3	-0.3	-1.0	0.0	-0.5	-0.1	0.2	0.7	-0.6	0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.8	-1.9	-0.5	-0.1	-1.2	-1.0	-0.3	1.9	0.7	0.2	-0.1	0.5	-0.3
Breast Cancer	1.3	3.0	10.8	3.3	-1.3	-1.3	2.4	0.5	0.4	-0.5	-2.1	-1.4	-2.3	-1.1	-1.6
Ovarian Cancer	1.3	1.8	5.2	-1.9	1.0	0.2	-0.7	1.1	-0.1	1.2	2.1	1.4	1.2	2.3	0.1
Prostate Cancer	0.5	0.8	3.3	0.2	1.0	0.4	0.1	0.2	0.5	-1.2	0.9	0.8	1.8	0.3	1.1
Age at First Birth	1.1	1.6	4.1	1.3	-2.0	0.2	0.8	-0.8	-1.5	-1.1	-2.0	-1.5	-1.4	0.1	-0.2
Bipolar Disorder (2011)	2.3	2.2	6.2	1.9	-1.4	-2.5	1.1	-0.4	-0.9	-1.1	-1.7	-1.5	-1.3	-1.6	-1.4
Body Mass Index (BMI) (2010)	0.7	0.9	4.1	-2.0	0.6	-0.1	-0.7	-0.1	0.2	0.6	1.3	0.9	0.9	1.4	0.7
Coronary Artery Disease (CAD)	1.8	2.2	6.2	2.2	0.2	-1.3	2.5	1.8	1.7	1.4	-0.6	0.1	-1.5	-0.8	-1.4
Crohns Disease (2012)	2.2	3.5	8.4	2.6	-1.8	-0.3	1.4	-1.2	-0.6	-2.9	-2.4	-2.1	-1.6	-2.0	-1.8
Mean Putamen Volume	1.2	1.4	3.2	-0.8	1.6	-0.4	-1.2	0.3	1.2	1.4	1.1	1.5	1.2	-0.1	1.8
Fasting Glucose	0.7	0.9	3.3	-0.8	0.1	1.1	-1.5	1.4	-0.6	0.0	-0.3	0.5	0.5	0.4	1.8
HbA1C	0.7	0.8	2.3	-1.1	1.1	0.3	-1.5	-0.7	1.2	-0.0	0.8	0.7	1.1	0.1	0.5
HDL Cholesterol	5.5	9.2	21.2	-4.6	1.3	0.4	-4.5	-1.4	-2.9	1.1	3.5	1.7	4.6	0.7	4.4
LDL Cholesterol	0.6	1.0	3.6	1.3	-0.3	0.7	1.8	0.4	1.9	0.0	-0.6	0.6	-1.0	0.5	-0.8
Lupus	0.8	1.2	3.4	-0.5	1.3	0.4	1.0	1.8	1.8	0.8	1.2	1.2	0.2	0.9	-0.3
Neuroticism (2016)	0.8	1.1	3.9	1.3	-0.7	0.5	1.0	-1.3	0.1	-2.0	-1.1	-1.2	-0.9	-0.1	-1.0
Primary Biliary Cirrhosis	0.4	0.6	1.9	-0.4	-0.5	-1.4	0.7	-0.2	-0.1	0.7	-0.9	-0.6	-1.4	-0.4	-0.4
Rheumatoid Arthritis	0.7	1.0	3.0	-0.2	1.7	0.6	0.6	1.3	0.8	-0.2	1.3	0.9	0.8	1.4	0.1
Schizophrenia (2014)	0.6	1.3	4.3	-0.2	1.8	1.3	0.4	0.7	2.1	0.9	1.0	1.4	-0.0	0.9	-0.8
Triglycerides	0.7	1.2	3.2	1.2	-1.4	-0.5	0.9	-0.5	-0.3	0.7	-1.8	-0.9	-1.5	-1.6	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	0.2	-0.3	-0.4	1.1	0.9	1.3	1.2	-0.2	-0.3	-1.0	-0.5	-0.7
Ulcerative Colitis	1.5	2.1	5.9	-0.9	-0.9	-2.4	-1.4	-1.1	0.1	-2.1	-1.5	-1.5	-1.5	-0.3	-2.0
Blood Eosinophil Count	0.1	0.4	1.2	0.2	-0.3	0.3	0.1	-0.7	-1.0	-0.5	0.4	0.2	0.6	1.1	1.1
Blood Platelet Count	0.1	1.2	3.4	-0.3	-1.1	-0.7	-1.6	-0.8	-1.9	0.5	-1.7	-0.8	-0.9	-1.3	0.4
Blood Red Count	0.2	1.6	10.0	0.0	-0.3	3.2	-1.5	-0.3	-1.4	-1.5	-0.5	-1.1	-0.1	0.8	-0.1
Blood White Count	0.2	1.7	5.0	-0.6	-1.4	0.3	-1.3	-1.5	-2.2	-1.3	-1.4	-1.8	-0.4	-1.1	0.6
Heel T-Score	0.4	3.4	10.8	-1.7	-1.8	1.5	-3.2	-0.2	-3.3	0.6	-0.0	-0.6	1.5	-1.4	2.4
BMI	0.3	1.9	6.5	2.5	-1.5	-0.0	0.7	-1.1	-0.7	-1.3	-1.5	-1.5	-0.7	-2.2	-0.3
Height	0.2	4.8	25.8	1.7	0.1	-5.1	2.5	-3.8	1.8	-0.1	1.0	1.2	0.0	1.2	-0.7
Waist Hip Ratio (WHR)	0.7	3.1	14.4	3.8	-0.5	1.7	2.6	1.2	0.7	0.2	-1.6	-0.8	-2.0	-0.9	-1.7
Systolic Blood Pressure	0.2	1.2	3.0	-0.1	-0.4	1.3	-1.0	1.1	-0.0	-1.6	-1.0	-1.2	-1.5	0.9	-1.7
Smoking Status	0.7	1.6	9.4	-1.1	1.9	-1.2	0.7	3.1	0.6	1.4	0.5	0.2	-0.4	0.3	-0.3
Allergy or Eczema	0.5	1.2	4.1	-2.0	-1.0	1.4	-1.2	-0.5	-0.9	-0.4	0.8	0.5	0.5	2.0	0.2
Cardiovascular Disease	0.8	2.7	7.3	2.7	-0.2	2.4	1.4	2.3	1.4	-2.0	-1.4	-0.5	-1.4	0.7	-1.4
Hypothyroidism (self reported)	0.2	0.5	2.2	0.7	-0.0	1.2	1.0	0.5	0.5	0.1	-0.5	-0.3	-0.4	-1.5	-0.3
Respiratory disease	0.6	1.3	3.3	0.2	-0.7	0.7	-1.4	-0.8	-1.6	-1.8	-1.0	-1.4	0.5	-1.8	0.3
Type 2 Diabetes (T2D) (2018)	0.8	1.5	8.5	-0.2	1.5	2.9	-1.3	1.1	1.2	-0.2	1.3	0.4	0.9	-0.1	0.2
Lung FEV1/FVC ratio	0.3	1.5	4.7	0.9	-1.9	-1.7	2.2	-1.6	0.1	0.5	-0.9	-0.5	-1.5	-0.1	-0.6
Lung FVC	0.3	1.6	4.6	-0.4	-1.9	-0.3	-0.8	-1.1	-1.7	1.0	-1.6	-1.2	-2.1	0.3	-1.0
Neuroticism	0.5	1.1	4.5	1.3	-0.1	2.1	1.5	1.0	0.9	-0.9	-0.6	-0.0	-0.8	1.0	-0.1
Chronotype (morning person)	0.5	1.2	2.3	-0.4	-1.0	0.1	-1.3	-1.2	-1.2	-1.4	-1.5	-1.5	-0.4	-1.3	0.3
Hair Pigment	0.1	2.9	6.7	-0.3	2.6	-0.5	0.4	1.6	2.6	0.7	2.2	2.4	1.3	2.3	0.2
Tanning	0.2	2.6	7.0	1.5	-1.4	-2.7	1.0	-2.4	-1.5	1.5	-1.7	-1.2	-1.3	-1.6	0.4
Hand grip strength (left)	1.7	4.6	8.8	2.4	-3.0	-1.9	1.6	-1.9	-1.9	-1.9	-2.5	-2.7	-2.2	-0.3	-2.2
Number of treatments/medications taken	0.5	1.0	2.5	1.3	0.2	0.2	1.0	1.4	0.6	-1.6	-1.3	-0.8	-1.1	0.1	-0.4
Average weekly spirits intake	1.7	2.1	5.5	0.6	-2.0	-0.4	-0.1	-2.3	-1.0	-0.2	-2.2	-1.6	-1.9	-1.5	-0.7
Sensitivity / hurt feelings	0.8	1.3	5.5	0.8	-1.2	2.3	0.2	-1.3	-1.8	-0.3	-1.1	-0.8	-0.5	-0.5	0.9
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.8	1.1	-1.6	1.0	0.7	0.3	-1.0	-1.4	-1.9	-1.5	-1.9	0.3	-1.6
Hearing difficulty/problems: Yes	0.4	0.6	2.8	-0.1	-0.1	-1.2	-0.3	0.2	0.2	-0.6	-0.6	-1.0	-1.2	-0.3	-1.7
Relative age of first facial hair	0.4	0.8	4.4	-1.3	0.6	0.2	-0.6	-0.5	-0.3	-1.5	0.2	-0.3	-0.2	2.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.3	0.7	-0.2	1.5	0.7	1.3	0.5	-0.3	-0.4	-0.5	-1.3	0.6	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.6	0.5	-0.4	-0.2	0.5	0.4	-0.4	0.0	0.6	0.7	1.4	-0.7	1.6
Ever had hysterectomy (womb removed)	1.3	1.5	7.2	-0.8	-1.1	-0.0	-0.3	0.4	-0.1	1.0	-1.6	-1.4	-2.7	-0.9	-1.5
Systolic blood pressure, automated reading	0.5	1.4	3.3	1.3	-1.2	-0.6	-0.2	0.3	-0.5	-1.7	-1.8	-1.4	-1.8	0.6	-1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.7	-0.1	0.5	0.8	-0.6	0.9	0.8	0.0	0.9	0.1	-0.1	1.3	-0.9
Angina	1.0	1.4	5.8	1.8	0.2	-0.3	2.4	1.5	1.0	-0.8	-1.1	-0.3	-0.8	-0.5	-1.0
Medication for hormone replacement therapy	0.3	0.4	1.3	0.8	-0.5	0.3	0.3	0.1	-0.4	-0.4	-0.6	-0.8	-1.1	0.4	-0.7
Vitamin and mineral supplements	0.4	0.6	2.0	-0.6	0.3	-0.1	0.2	-1.2	0.8	1.3	1.4	0.6	0.3	0.4	0.1
Supplements: Zinc	0.5	0.6	4.8	-0.7	-0.4	0.3	-2.2	0.1	-0.7	-0.3	-0.2	0.0	0.4	-0.5	0.7
Medication: Co-codamol	0.8	0.9	3.0	0.4	0.4	1.0	1.2	0.9	1.7	1.5	0.4	0.8	-0.7	1.0	-0.1
Medication: Metformin	0.6	0.9	2.5	0.1	1.4	1.1	0.0	0.3	1.6	0.2	1.5	0.8	1.1	-0.1	0.5
Diabetes (father)	1.1	1.4	4.8	0.5	-1.2	-0.3	0.6	-2.2	-1.9	0.7	-1.3	-1.2	-1.4	-0.5	0.9
Diabetes (mother)	1.9	2.4	7.0	-0.4	-1.4	1.9	-1.8	-2.6	-1.5	-0.6	-1.2	-1.9	-1.0	-1.9	-1.1
Severe depression (siblings)	0.3	0.3	1.5	-1.2	-0.6	0.0	-0.2	-1.2	-0.6	0.5	0.2	-0.0	-0.1	0.4	-0.0
Pack years adult smoking proportion	0.9	1.4	4.1	1.5	-0.0	0.4	1.4	-0.3	0.7	-1.2	-1.1	-1.4	-0.5	-2.0	-1.6
Impedance of leg (right)	0.4	1.9	7.2	-1.1	0.9	1.9	0.2	2.7	0.6	2.6	0.7	0.9	-0.5	1.0	0.6
Leg fat-free mass (left)	0.7	3.8	15.4	2.8	-1.9	-2.6	1.3	-3.9	-0.8	-2.0	-1.4	-1.5	-0.5	-1.3	-0.4
Trunk fat percentage	0.6	2.3	11.9	3.5	-1.2	0.3	2.7	-0.9	0.1	-0.0	-1.5	-1.1	-1.4	-0.8	-0.2
Hand grip strength (right)	0.5	1.4	3.4	1.7	-1.3	-1.8	1.2	-1.1	-0.4	-0.8	-0.5	-1.2	-0.9	0.5	-1.6
Townsend deprivation index at recruitment	0.9	1.2	5.9	0.7	0.5	1.9	2.4	1.7	0.8	0.2	-0.2	0.1	-0.2	-0.3	-0.7
Current tobacco smoking	0.3	0.5	2.2	-1.5	0.0	-0.7	-0.0	0.6	-0.3	1.0	-0.4	-0.7	-0.5	-1.2	0.1
Average weekly fortified wine intake	0.3	0.4	2.2	-0.4	-0.1	-0.1	0.0	0.1	-0.1	1.5	-0.7	-0.1	-1.3	-0.0	0.0
Maternal smoking around birth	0.6	0.9	6.6	0.4	-0.4	0.1	0.3	0.2	-1.0	0.3	-1.2	-0.8	-0.0	-2.6	0.7
Fed-up feelings	0.5	0.9	5.5	1.5	-1.3	0.2	2.3	-0.5	-0.0	-0.1	-0.8	-0.4	-0.6	0.2	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	1.2	0.4	1.2	0.7	1.2	0.4	-1.2	-0.8	-0.8	-0.6	0.1	-0.6
Relative age voice broke	0.8	1.2	3.5	-1.8	-0.1	-0.8	-1.3	-1.2	-1.4	-1.5	0.4	-0.0	0.5	1.9	0.4
Taking other prescription medications	0.2	0.3	1.7	-0.1	0.1	-0.3	-0.3	1.3	-0.2	-0.1	-0.9	-0.4	-0.6	-0.6	-0.3
Age when periods started (menarche)	0.4	0.9	2.8	0.6	-1.5	-0.8	1.7	-0.5	-1.5	1.0	-0.6	-0.1	-0.2	-1.0	0.8
Bilateral oophorectomy (both ovaries removed)	2.1	2.5	5.1	-1.3	-2.0	-1.0	-1.0	-0.8	-1.9	-0.6	-2.0	-2.2	-1.5	-2.3	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	9.4	-0.9	-2.5	1.6	-3.1	-1.2	-2.9	1.0	-1.7	-1.2	-0.7	-2.0	1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	0.1	1.0	-0.1	-0.3	0.9	0.6	-0.6	0.4	0.7	0.5	0.0	0.5
Qualifications: CSEs or equivalent	0.2	0.2	1.2	-0.5	0.3	0.2	0.4	0.1	-0.2	0.8	-0.3	-0.2	-0.5	-1.1	0.3
Serious illness, injury or assault to yourself	0.5	0.6	4.0	-0.5	-0.7	0.9	0.5	0.4	-0.1	-0.1	-1.0	-0.5	-0.3	-2.0	0.1
High blood pressure	0.6	1.6	4.2	1.9	0.4	1.6	1.1	1.8	2.1	-1.0	-0.7	0.0	-1.0	0.9	-1.3
Hayfever, allergic rhinitis or eczema	1.0	2.1	7.1	-2.7	-0.4	1.5	-2.4	-0.4	-1.7	-0.2	1.2	0.8	1.4	1.5	0.9
Multivitamins +/- minerals	0.9	1.1	4.1	1.1	-1.2	-0.1	-0.3	0.7	-2.0	-1.6	-1.3	-0.9	0.1	-1.0	0.5
Stomach or abdominal pain in last month	1.3	1.7	6.1	1.3	-1.0	-2.1	2.5	0.6	0.4	0.8	-0.9	-0.4	-1.7	0.2	-1.3
Supplements: Glucosamine	0.7	0.9	2.0	-0.5	0.7	-0.9	-0.9	-1.3	-1.1	-0.4	0.2	0.1	1.4	-1.4	1.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	4.4	-2.1	0.9	-0.0	-0.9	0.6	-0.2	0.9	1.2	1.0	0.8	1.2	0.3
Medication: Atenolol	1.0	1.3	4.8	-0.6	0.5	0.2	0.4	2.2	1.1	0.1	1.6	1.6	1.2	1.5	0.5
Medication: Levothyroxine sodium	0.4	0.7	1.5	0.9	-0.2	-0.1	1.1	0.5	0.4	-1.2	-1.0	-1.0	-1.1	-0.5	-1.2
Sitting height	0.3	2.2	12.0	0.7	-0.4	-3.5	-0.1	-3.3	0.1	-1.2	0.5	0.4	1.1	0.1	0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	2.4	-1.2	-0.1	1.0	-1.6	0.3	0.1	1.0	0.2	-0.1	-0.5	0.0	-0.2
High blood pressure (mother)	0.3	0.5	1.8	0.2	0.6	-0.0	-0.3	1.0	1.3	0.5	-0.2	0.3	0.1	-1.3	0.4
Body mass index (BMI)	0.5	2.1	7.3	2.7	-1.5	-0.6	0.9	-1.5	-1.2	-1.3	-1.3	-1.3	0.0	-2.2	0.6
Impedance of leg (left)	0.4	1.9	8.6	-0.8	1.1	1.6	0.7	2.9	0.8	2.5	0.5	0.8	-0.8	0.8	-0.0
Leg predicted mass (left)	0.7	3.9	15.4	2.7	-2.0	-2.7	1.3	-3.9	-0.8	-2.0	-1.4	-1.5	-0.5	-1.3	-0.4
Trunk fat mass	0.7	3.0	13.2	3.6	-1.6	-0.8	2.7	-2.0	-0.1	-0.4	-1.6	-1.2	-1.3	-1.2	-0.2
Waist circumference	0.7	2.5	11.6	3.4	-1.5	-0.7	1.5	-1.4	-0.9	-0.9	-1.6	-1.5	-0.6	-2.1	0.2
Number of incorrect matches in round	0.5	0.8	2.2	-0.0	-0.7	0.8	-0.8	-1.1	-1.5	-1.2	-0.9	-1.1	-0.2	-0.5	-0.0
Past tobacco smoking	0.5	1.0	5.1	0.3	-1.0	-0.6	-0.4	-2.3	0.5	-0.3	-0.5	-0.1	0.5	-2.0	0.5
Alcohol usually taken with meals	0.4	0.7	2.1	0.0	0.5	-1.5	-1.4	-0.5	-0.1	-1.2	0.2	-0.4	0.2	-0.2	-1.4
Nervous feelings	1.0	1.9	8.3	0.2	1.5	2.6	0.2	1.1	1.6	-0.1	0.7	1.3	0.1	2.9	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.4	0.2	0.5	1.5	-0.2	0.8	0.7	0.4	-0.2	0.4	-0.1	0.6	0.6
Hearing difficulty/problems with background noise	0.3	0.5	2.1	1.0	0.7	-1.4	0.9	-0.2	1.1	0.3	0.2	0.5	-0.2	0.5	0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	-0.2	0.3	1.3	-0.7	0.5	-0.1	-1.3	0.8	0.1	0.7	1.3	-0.3
Had menopause	0.7	0.9	2.4	0.8	0.8	1.1	0.1	0.9	-0.1	-0.9	1.0	1.0	1.1	1.6	0.9
Had other major operations	1.1	1.4	3.5	0.6	-1.2	-0.6	0.2	-0.5	-0.6	-1.4	-1.9	-1.7	-1.6	-0.4	-1.5
Forced vital capacity (FVC)	0.6	2.2	5.6	0.8	-2.1	-1.7	-0.3	-2.4	-1.6	-0.4	-1.9	-1.6	-1.5	-1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	8.0	-0.9	-2.3	1.6	-2.8	-1.2	-2.3	0.7	-1.8	-1.1	-0.8	-1.7	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.7	-1.3	-0.2	-0.2	-0.4	-0.7	-0.2	1.3	-0.2	0.0	-0.8	-0.3	0.2
Qualifications: None of the above	0.2	0.4	1.4	0.4	-0.7	0.2	0.7	0.7	-1.2	-0.2	-0.8	-0.7	-0.0	-0.5	0.6
Financial difficulties in last 2 years	0.6	0.8	3.1	0.6	0.6	1.8	1.3	1.0	0.9	0.9	0.0	0.6	0.1	-0.3	0.7
Mouth/teeth dental problems	1.4	2.1	10.6	-3.1	0.4	0.4	-3.3	-0.3	-0.5	1.0	1.3	0.2	0.9	0.1	0.8
Heart attack	0.9	1.1	4.5	1.6	0.2	-0.2	2.1	0.9	0.8	-0.8	-0.4	-0.5	0.1	-1.7	-0.9
Allergy	0.6	1.3	3.9	1.9	1.0	-1.1	2.0	1.0	1.9	0.7	-0.1	0.7	-0.3	-0.6	0.0
Pain all over the body in last month	0.8	0.8	4.0	1.6	-0.7	-0.9	0.4	-0.3	-0.5	-2.0	-0.8	-0.3	0.3	-0.6	-0.0
Diabetes (self-reported)	1.4	2.2	6.6	0.3	2.2	2.6	-1.4	2.0	1.6	1.0	1.5	0.8	1.1	-0.6	0.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	6.4	-2.1	-0.2	-0.6	-2.5	0.5	-1.0	0.1	0.5	0.4	0.7	0.4	0.6
Medication: Ramipril	1.3	1.7	5.2	1.9	0.0	-1.2	1.8	0.7	0.8	-2.1	-0.6	-0.8	-0.4	-0.5	-2.3
Medication: Simvastatin	3.0	4.4	9.0	2.8	2.1	0.4	2.8	2.4	3.0	0.4	1.6	2.6	1.3	2.3	1.2
Fluid intelligence score	0.3	0.6	2.6	-0.6	-0.8	-0.1	-0.5	-1.0	-0.3	1.6	-0.2	-0.5	-1.1	0.2	-0.3
Illnesses of siblings	0.9	1.2	3.3	-0.7	0.3	-0.8	-0.6	-0.4	0.1	1.3	1.6	1.4	1.7	0.8	1.8
Neuroticism score	1.0	2.0	9.0	1.9	-1.2	3.0	1.4	-0.4	-0.2	-1.1	-1.5	-1.0	-1.6	0.6	-0.4
Weight	0.8	3.8	11.0	3.3	-2.0	-2.1	1.6	-3.2	-1.1	-1.7	-1.5	-1.6	-0.3	-2.0	0.2
Impedance of arm (right)	0.3	1.2	4.0	-0.5	1.0	1.1	1.0	1.3	1.2	1.5	0.8	0.8	-0.2	2.0	-0.0
Arm fat percentage (right)	0.5	1.8	7.5	2.7	-1.2	-0.3	1.6	-1.1	-0.7	-0.5	-1.5	-1.3	-0.6	-1.8	0.4
Trunk fat-free mass	0.7	3.8	16.2	2.2	-1.8	-3.5	0.8	-4.0	-0.8	-1.7	-1.0	-0.9	0.1	-1.7	-0.1
Hip circumference	0.4	1.8	4.4	2.0	-1.2	-1.8	0.4	-2.1	-0.9	-1.3	-0.8	-1.2	0.4	-1.9	0.6
Time employed in main current job	0.4	0.5	2.2	-1.3	-0.3	0.2	-0.5	-0.3	0.0	0.0	0.3	-0.3	-0.9	1.5	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	2.2	0.2	0.8	-1.1	0.8	1.5	0.5	-0.2	0.9	0.6	1.0	1.1	0.6
Father’s age at death	1.1	1.4	3.1	-1.7	-0.2	-1.7	-0.9	-1.2	-0.8	1.8	0.7	1.0	-0.0	1.3	1.6
Worrier / anxious feelings	0.8	1.5	12.3	0.7	-0.6	3.5	0.2	-0.7	-0.7	-1.3	-1.3	-0.6	-0.7	0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.8	1.3	-1.4	0.8	1.5	0.1	-0.4	-0.5	-1.7	-1.3	-1.1	-2.2	-0.5
Falls in the last year	0.2	0.3	1.1	-0.2	-0.0	0.6	-0.8	0.5	-0.6	-0.1	-0.3	-0.1	0.4	-0.8	1.0
Hair/balding pattern: Pattern 3	0.5	0.8	3.0	0.7	0.4	0.0	1.2	0.6	1.7	1.5	-0.4	0.7	-0.8	-0.5	0.3
Number of live births	1.2	1.6	6.6	1.8	1.4	0.9	0.5	2.6	1.7	-0.8	-0.2	-0.2	-0.4	0.1	-1.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	6.8	0.9	-2.6	-1.9	-0.1	-2.4	-1.6	-0.5	-1.9	-1.6	-1.6	-1.0	-1.0
Pulse rate	0.4	0.6	1.8	-0.4	-0.1	0.9	-0.7	-0.7	0.9	-1.3	0.3	-0.3	-0.3	0.9	-1.3
Happiness	0.2	0.2	0.9	-0.2	-0.7	0.5	0.9	-0.5	-0.3	-0.2	0.2	0.2	-0.2	0.9	-0.2
Noisy workplace	0.1	0.1	0.3	-0.1	-0.3	0.2	0.6	0.1	-0.1	-0.0	-0.4	0.0	-0.3	0.5	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	0.5	-0.8	0.1	0.3	-0.9	-0.2	-0.1	-0.7	-0.7	-0.8	-1.1	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	0.9	-1.3	-0.9	0.8	-0.3	-0.5	-0.4	-0.8	-0.4	-1.3	0.7	-0.6
Mouth/teeth dental problems: Dentures	1.9	3.2	6.9	1.7	2.3	-0.5	2.6	1.5	1.7	0.8	2.0	2.4	2.0	1.0	1.6
Asthma	0.9	1.8	3.8	1.2	-1.9	0.7	0.1	-1.4	-1.7	-1.3	-1.8	-1.9	-0.9	-1.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.4	-1.9	-1.3	0.1	-1.6	-1.1	-2.1	-1.4	-0.8	-1.3	-0.2	0.1	-0.7
Medication: Cholesterol lowering	1.4	2.2	6.4	2.0	1.6	-0.3	2.5	2.3	2.5	0.2	0.6	1.2	0.5	0.2	0.4
Depression (self-reported)	0.9	1.1	2.7	0.0	-1.2	-1.5	-0.5	-0.7	-0.6	-1.6	-1.0	-1.5	-0.6	-1.0	-0.7
Medication: Lansoprazole	1.3	1.4	4.7	-1.1	2.0	1.4	0.0	2.2	1.6	-0.2	1.1	0.6	1.0	-0.4	-0.1
Prospective memory result	1.9	2.4	4.4	1.6	-2.1	-1.5	1.6	-1.3	-1.5	-1.6	-1.6	-1.8	-1.2	-1.6	-0.9
Lung cancer (father)	1.1	1.3	4.9	-2.2	0.0	1.0	0.5	-0.7	0.2	1.9	1.1	1.1	0.4	1.0	1.6
Illnesses of mother	0.2	0.3	1.0	0.6	0.4	0.1	0.6	0.1	0.2	0.1	0.8	0.6	1.0	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	5.2	1.1	-2.3	-1.4	0.8	-1.9	-0.7	-0.2	-1.9	-1.3	-1.9	-1.0	-1.3
Pulse wave Arterial Stiffness index	1.5	1.7	8.6	-2.4	0.2	0.3	-2.9	0.5	-0.3	-1.6	1.2	0.3	1.3	0.3	0.2
Impedance of arm (left)	0.3	1.3	3.2	0.1	0.4	1.8	1.4	1.0	1.2	1.3	-0.1	-0.0	-1.5	1.6	-0.9
Arm fat mass (right)	0.7	3.0	10.5	3.2	-1.8	-1.1	1.7	-2.4	-1.1	-1.1	-1.8	-1.6	-0.7	-2.0	0.4
Trunk predicted mass	0.7	3.9	16.8	2.1	-1.9	-3.5	0.7	-4.1	-0.9	-1.7	-1.0	-0.9	0.1	-1.8	0.0
Standing height	0.4	3.5	15.6	2.1	-1.1	-3.8	2.1	-4.0	0.4	-0.9	-0.3	-0.3	-0.5	0.1	-0.9
Length of working week for main job	1.3	1.4	4.5	0.9	-0.5	-2.1	0.7	-1.1	-0.3	-1.6	-1.1	-1.4	-1.2	-0.5	-1.5
Exposure to tobacco smoke at home	1.1	1.2	5.7	1.2	0.6	2.4	1.5	1.1	0.5	-0.7	-1.0	-0.3	-0.6	-1.0	-0.3
Breastfed as a baby	0.4	0.5	2.3	-0.6	0.0	-0.3	-1.5	-0.7	0.0	-1.2	0.5	0.1	0.7	-0.1	-0.2
Tense / ‘highly strung’	1.6	2.7	9.2	1.9	-1.6	0.9	1.2	-1.0	-0.6	-0.2	-2.4	-2.0	-3.0	-0.5	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.4	0.4	-1.4	1.4	0.1	-0.9	-0.9	-1.1	-1.6	-1.6	-1.2	-0.6	-0.6
Hair/balding pattern: Pattern 4	0.4	1.1	3.1	-0.9	1.6	0.5	-0.4	1.8	1.0	0.8	1.0	1.2	1.1	-0.6	0.7
Birth weight of first child	2.6	4.6	14.5	3.0	-2.0	1.1	0.6	-1.2	-1.0	-0.4	-2.9	-2.8	-3.8	-0.9	-2.6
Peak expiratory flow (PEF)	0.4	0.8	4.1	0.3	-1.1	-2.0	0.0	-0.8	-1.3	0.6	-0.7	-0.7	-0.8	-0.4	-0.4
Pulse wave reflection index	1.2	1.5	4.2	-1.4	0.8	0.8	-1.1	0.8	-0.7	0.8	1.4	1.3	1.9	-0.3	2.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	4.0	-0.9	1.0	0.2	0.9	1.6	0.6	-0.3	1.0	1.1	0.4	2.0	0.4
Loud music exposure frequency	0.9	1.0	2.5	-1.2	1.0	-0.9	-1.5	0.7	0.2	0.2	1.3	0.9	1.6	0.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.4	0.1	-0.8	0.6	0.2	-1.2	-0.2	0.1	0.2	-0.4	-0.2	-0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.1	1.4	-0.6	1.8	1.0	-0.1	0.2	1.0	-0.4	0.6	-0.9	0.8	0.3
Blood clot in the leg (DVT)	0.5	0.7	1.9	0.9	-0.5	-1.4	1.3	-0.6	0.1	-0.3	-0.9	-1.0	-0.7	-0.8	-0.4
Medication: Paracetamol	0.3	0.5	1.3	0.4	-0.6	-0.1	0.2	-1.1	-0.8	-0.3	-0.9	-0.1	0.2	-1.1	1.0
Headache pain in last month	0.7	1.3	4.1	-0.8	-1.7	0.9	-0.8	-1.7	-2.0	0.1	-1.0	-0.6	-0.1	-0.8	1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.9	-1.3	-0.9	-1.0	-1.8	-2.6	-2.3	0.2	-0.0	-0.8	0.3	-0.9	0.3
Glaucoma (self-reported)	0.8	0.9	2.1	0.4	-0.1	0.8	0.9	1.1	0.8	-0.6	-1.5	-0.7	-1.4	-1.0	-1.2
Gout (self-reported)	1.1	1.6	5.9	0.4	1.4	0.0	-0.3	2.4	1.6	1.5	1.4	1.4	1.4	-0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	0.3	0.6	0.6	1.1	0.9	1.1	-0.2	-0.1	0.3	-0.2	-0.3	-0.3
Medication: Amlodipine	0.4	0.6	2.7	-0.0	0.2	-0.4	1.1	1.6	1.6	-0.3	0.0	0.2	-0.4	0.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.2	5.1	2.2	-0.9	-0.1	-0.0	-1.1	-0.6	-1.3	-1.3	-1.3	-1.0	-0.2	-0.9
Birth weight	0.2	0.5	1.7	0.8	-0.5	-0.9	1.2	-1.3	-0.3	0.2	-0.1	0.2	0.2	0.4	0.8
Chronic bronchitis/emphysema (mother)	1.7	2.0	5.6	-1.2	1.4	1.9	-1.2	0.6	0.9	-0.8	1.9	1.2	1.7	2.4	0.5
High blood pressure (siblings)	0.5	0.7	2.6	0.6	0.2	-0.1	0.4	1.1	0.6	0.2	-0.9	-0.3	-1.6	-0.3	-1.6
Forced vital capacity (FVC), Best measure	0.7	2.5	5.8	0.8	-2.4	-1.2	0.1	-2.1	-1.1	-0.4	-2.3	-1.8	-2.1	-1.2	-1.4
Body fat percentage	0.5	1.8	8.9	3.0	-1.0	0.2	2.2	-0.6	-0.1	0.1	-1.4	-1.1	-1.1	-1.3	0.0
Leg fat percentage (right)	0.4	1.4	6.6	2.6	-1.0	0.3	1.4	-0.2	-0.6	0.2	-1.3	-1.0	-0.8	-1.8	0.5
Arm fat-free mass (right)	0.7	3.5	12.5	2.8	-2.0	-2.4	1.1	-3.5	-1.1	-1.4	-1.4	-1.3	-0.5	-1.9	-0.2
Exposure to tobacco smoke outside home	0.6	0.8	2.9	0.4	-0.7	-0.7	0.9	-1.3	-0.9	-0.4	-0.9	-1.0	-0.1	-1.7	0.5
Comparative body size at age 10	0.1	0.3	1.4	-0.1	0.5	-0.6	-0.2	0.5	1.2	0.5	0.3	0.2	-0.7	0.4	-0.9
Number of full brothers	0.6	0.8	3.7	-1.2	1.2	0.7	-1.9	0.9	0.2	0.7	0.4	0.1	0.4	-0.3	0.5
Worry too long after embarrassment	1.3	2.1	5.4	1.8	-1.7	2.3	1.4	-2.0	-1.1	-1.1	-1.7	-1.2	-1.0	-0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.2	0.6	-0.5	-0.2	0.7	-0.0	-0.3	-1.5	-0.5	-0.3	-0.3	1.4	-0.3
Wheeze or whistling in the chest in last year	0.5	1.0	3.6	0.4	-0.0	1.9	0.5	-0.5	-0.7	-0.0	-1.2	-1.3	-0.7	-1.8	0.0
Number of children fathered	1.6	1.8	6.8	1.6	0.8	-1.6	2.6	-0.2	2.1	-0.5	0.8	0.8	0.0	1.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.7	0.1	0.9	-0.8	-0.3	-0.2	-1.5	1.2	0.4	0.9	1.7	-0.2
Age at first live birth	0.4	0.8	3.3	-0.9	-0.3	-0.5	0.1	-1.8	0.3	1.5	0.8	0.4	-0.5	0.9	-0.7
Pulse wave peak to peak time	1.8	2.2	10.0	2.7	-0.3	-0.5	3.2	-0.8	0.4	1.4	-1.5	-0.5	-1.5	-0.4	-0.5
Health satisfaction	0.5	0.7	4.1	1.1	-0.2	-0.6	2.0	0.1	0.3	-0.2	-0.8	-0.5	-0.9	-0.3	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.8	-0.0	-0.3	-0.4	0.7	-0.2	-0.3	-0.9	-0.5	-0.5	-0.6	0.6	-0.0
Qualifications: College or University degree	0.1	0.4	1.0	0.6	-0.0	0.2	0.1	-1.0	1.0	-0.8	0.3	0.2	0.4	-0.6	-0.8
Eye problems/disorders: None of the above	1.0	1.2	5.6	-0.1	-1.7	0.0	1.0	-2.4	-1.2	0.5	-0.5	-0.6	-1.1	0.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.7	0.1	-0.4	0.2	-0.8	1.6	-0.8	-1.1	-1.4	-1.4	-0.7	-1.5	-0.9
Emphysema/chronic bronchitis	0.7	0.7	2.5	0.0	-0.5	-0.6	-0.6	-0.4	-1.1	-0.3	-0.8	-1.6	-0.9	-1.4	-0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	2.3	-0.7	0.6	0.1	-0.5	0.7	1.1	0.8	1.5	0.6	0.4	0.9	-0.6
Neck or shoulder pain in last month	0.5	0.7	2.2	-1.0	0.6	-0.6	-0.4	0.8	0.1	0.6	0.6	0.6	1.4	-0.7	1.5
Medication: Blood pressure	0.8	1.3	5.1	0.4	0.7	2.0	0.6	2.2	2.3	-0.2	0.1	0.8	0.1	0.5	0.1
Angina (self-reported)	1.1	1.4	6.8	1.6	0.7	-0.5	2.6	1.7	1.4	-0.6	-0.6	0.1	-0.4	-0.1	-0.8
Migraine (self-reported)	0.3	0.4	1.3	0.6	0.3	0.0	1.0	-0.2	1.1	-0.3	0.5	0.9	0.6	0.6	-0.0
Medication: Ibuprofen	2.3	2.7	6.2	-0.9	-1.9	0.2	-0.9	-1.2	-2.2	-2.1	-1.8	-2.5	-1.5	-0.6	-2.1
Medication: Allopurinol	0.4	0.5	1.2	0.6	0.7	0.4	-0.8	0.9	0.4	0.4	0.6	0.6	1.1	-1.0	0.4
Medication: Omeprazole	0.8	1.0	2.4	-0.1	1.5	-1.5	0.7	1.2	1.3	1.1	0.7	1.0	0.2	0.6	0.7
Medication: Seretide 50 evohaler	0.2	0.3	0.8	-0.0	-0.4	0.1	-0.7	-0.0	-0.9	-0.6	-0.1	-0.9	0.2	-0.6	-0.4
Mean time to correctly identify matches	0.1	0.3	1.2	-0.1	0.9	-0.7	0.1	-0.2	1.1	-0.0	0.4	0.7	0.4	0.0	0.3
Heart disease (mother)	0.3	0.3	0.8	-0.7	-0.4	-0.9	-0.3	0.1	-0.5	0.4	-0.0	0.7	-0.0	0.9	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	0.1	0.9	0.6	-0.4	1.1	0.9	1.1	1.1	1.2	0.4	1.1	0.3
Whole body fat mass	0.5	2.2	9.2	3.0	-1.3	-0.9	2.1	-1.7	-0.4	-0.4	-1.4	-1.2	-0.9	-1.4	0.1
Leg fat mass (right)	0.6	2.2	7.8	2.8	-1.5	-1.0	1.5	-1.7	-1.1	-0.4	-1.4	-1.2	-0.5	-2.1	0.7
Arm predicted mass (right)	0.6	3.0	9.5	2.7	-1.6	-2.4	1.0	-3.1	-0.8	-1.5	-1.3	-1.2	-0.2	-2.0	-0.1
Pulse rate, automated reading	0.1	0.4	1.7	-0.6	-0.5	1.0	-0.4	-1.1	0.2	-0.2	0.6	-0.0	-0.4	1.3	-0.5
Alcohol intake frequency.	0.3	0.6	3.1	0.6	-0.5	-0.0	-0.5	-1.0	-0.8	-0.1	-0.1	0.3	1.1	-0.7	1.8
Comparative height size at age 10	0.2	1.3	8.3	1.4	-0.4	-1.6	0.7	-2.9	0.9	0.1	-0.2	-0.1	-0.5	-0.7	-1.1
Number of full sisters	1.0	1.3	3.0	-0.1	1.7	0.6	-0.5	1.6	1.6	-1.2	0.4	-0.4	0.8	-1.2	-1.5
Suffer from ‘nerves’	1.0	1.6	11.6	0.6	-0.6	3.4	-1.3	-0.9	-1.0	-0.7	-1.3	-0.5	-0.3	-0.4	1.0
Overall health rating	0.5	1.2	3.1	1.4	-0.4	0.9	1.6	0.8	0.5	0.9	-1.5	-0.6	-1.8	-1.0	-0.3
Chest pain or discomfort	0.4	0.6	1.9	1.4	0.5	1.1	0.8	1.2	0.6	0.9	-0.5	0.2	-0.6	0.0	0.3
Had major operations	1.1	1.3	3.6	0.9	0.9	0.3	1.6	1.9	1.6	0.3	0.9	0.7	-0.1	1.9	-0.4
Age at last live birth	0.6	0.9	3.1	-0.1	1.1	0.5	0.2	0.0	1.8	1.5	1.1	0.7	-0.4	0.8	-1.1
Family relationship satisfaction	0.6	0.8	1.7	0.2	0.4	1.1	1.0	-0.3	0.8	1.3	1.3	1.1	0.8	0.4	1.0
Leg pain on walking	0.2	0.2	0.9	-0.9	0.4	-0.3	-0.3	0.8	-0.5	-0.0	0.4	0.0	0.2	0.3	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.7	0.0	1.2	-1.3	0.7	0.7	1.0	0.4	0.3	0.6	0.5	-0.1	-0.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	8.0	0.0	0.9	0.1	0.0	1.5	1.5	-1.1	1.1	0.9	0.4	2.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	-0.2	-0.9	-1.2	-1.2	-1.6	-1.5	-0.5	-0.1	-0.4	0.3	-0.2	-0.0
Medication: Aspirin	0.8	1.0	3.9	1.9	-0.2	0.7	0.7	0.8	-0.2	-1.0	-1.3	-0.3	-0.0	-2.0	0.4
Supplements: Vitamin C	0.3	0.3	1.4	-1.2	0.7	0.0	-0.8	-0.0	0.8	0.7	-0.2	0.5	-0.3	0.3	0.2
Knee pain experienced in last month	0.2	0.4	1.1	-0.6	0.8	-0.4	0.2	1.0	0.9	0.7	0.4	0.5	0.3	-0.6	0.0
Hypertension (Self-reported)	0.6	1.6	3.6	1.9	0.2	1.9	0.8	1.5	1.9	-1.1	-0.7	0.1	-1.0	1.0	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	4.9	-1.8	2.1	-0.3	0.2	2.2	0.6	1.4	1.8	1.5	1.1	1.6	1.3
Illnesses of father: Heart disease	2.0	2.7	14.4	3.8	-2.0	-1.2	1.6	-1.0	-0.4	-0.4	-1.9	-0.7	-1.0	-1.9	0.2
Illnesses of siblings: Diabetes	1.4	1.7	8.9	-0.5	2.0	3.0	-1.1	1.4	1.5	0.1	0.9	0.8	0.4	0.7	-0.2
Smoking status: Previous	1.1	1.7	6.1	0.3	2.2	-0.3	0.5	2.5	0.5	0.3	1.3	1.1	0.4	2.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	0.2	0.5	-0.9	0.6	-0.9	1.1	1.1	0.7	0.5	0.1	-0.6	0.1
Whole body fat-free mass	0.7	3.8	15.8	2.4	-1.8	-3.1	1.1	-4.0	-0.8	-1.9	-1.2	-1.2	-0.2	-1.6	-0.3
Leg fat-free mass (right)	0.7	3.9	14.7	2.8	-1.7	-2.8	1.5	-3.8	-0.6	-2.1	-1.4	-1.4	-0.4	-1.3	-0.6
Arm fat percentage (left)	0.6	2.5	9.5	3.1	-1.5	-0.1	1.9	-1.3	-0.6	-0.6	-1.9	-1.8	-1.2	-2.0	-0.0
Average weekly red wine intake	1.0	1.5	6.3	0.9	-0.5	-1.2	0.1	-0.7	-0.9	-2.5	-0.9	-1.4	-0.8	0.5	-2.1
Handedness (chirality/laterality): Left-handed	2.9	3.5	8.9	-0.3	-2.7	1.1	-0.8	-1.6	-3.0	-0.7	-2.5	-2.7	-2.4	-0.9	-1.0
Mood swings	0.5	1.0	4.4	2.1	0.2	0.9	1.7	1.3	0.8	-0.4	-0.5	-0.2	-0.6	0.3	-0.3
Loneliness, isolation	0.7	1.0	4.5	1.4	-0.9	1.5	2.1	-0.8	0.4	-0.3	-0.5	-0.1	-0.5	0.9	0.0
Long-standing illness, disability or infirmity	0.7	1.0	4.1	-0.4	0.9	2.0	0.1	2.0	1.1	-0.2	0.6	0.5	0.1	1.1	0.0
Ever had bowel cancer screening	0.5	0.6	2.6	-0.3	0.2	-1.0	-0.3	-0.2	-0.1	0.9	0.1	0.8	0.8	-1.1	1.6
Diabetes diagnosed by doctor	1.3	2.2	7.5	0.4	2.1	2.7	-1.0	1.6	1.4	0.9	1.8	1.1	1.3	0.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.7	0.6	0.0	0.3	-0.5	-0.3	-0.6	-0.4	-0.5	-1.0	-0.3	-1.3	-1.2
Friendships satisfaction	0.7	0.8	2.5	0.0	0.0	0.6	0.6	-1.6	-0.1	1.3	1.3	0.8	1.0	0.6	1.2
Qualifications: nursing, teaching	1.7	2.6	6.3	-2.0	2.1	1.2	-1.4	0.5	2.1	-0.4	2.5	1.8	2.0	1.3	0.4
Commuting to job workplace: Walk	1.0	1.0	4.3	0.7	0.1	-0.1	0.1	0.4	0.5	-1.4	-0.9	-1.3	-0.8	-1.5	-2.1
Eye problems/disorders: Cataract	0.9	1.0	2.8	0.2	1.6	-0.6	-1.5	1.7	0.8	0.6	0.9	0.8	1.2	-0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	3.9	6.3	11.6	2.2	-3.3	0.1	1.2	-2.3	-2.3	-3.3	-3.4	-3.3	-2.2	-2.0	-2.3
Medication for cholesterol	0.2	0.4	1.4	-1.2	-0.2	0.7	-0.2	-0.8	-0.7	0.9	0.3	-0.1	-0.1	0.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.6	-0.7	-1.3	-0.6	-0.5	-0.1	-1.0	1.9	-0.6	0.2	-0.6	-0.7	0.6
Back pain experienced in last month	1.5	2.2	3.7	-1.1	1.7	-0.7	1.1	1.8	1.1	1.6	1.7	1.9	1.0	1.7	1.4
Mineral and other dietary supplements	0.6	0.8	2.6	0.6	-0.8	-1.2	1.1	-0.2	-0.1	1.5	-0.4	-0.6	-1.6	-0.1	-1.1
Breast cancer (self-reported)	1.7	2.0	5.9	2.4	-0.4	1.4	2.2	0.5	0.5	-0.7	-1.4	-1.4	-1.0	-2.0	-1.2
Asthma (self-reported)	0.9	1.7	3.7	1.1	-1.6	0.9	-0.3	-1.1	-1.6	-1.6	-1.8	-1.9	-0.8	-1.3	-0.5
Osteoporosis (self-reported)	0.9	1.1	4.6	0.4	1.7	0.1	1.2	2.1	1.2	0.1	0.7	0.9	0.6	1.0	0.5
Osteoarthritis (self-reported)	1.9	2.5	5.6	-0.1	-1.4	-1.8	-0.3	-1.6	-1.4	-0.4	-2.2	-2.4	-2.0	-1.8	-1.5
Medication: Aspirin	0.9	1.1	5.0	2.2	0.4	1.0	0.7	1.6	0.6	-0.9	-1.1	0.2	-0.1	-1.5	0.2
Medication: Gliclazide	1.8	2.0	9.4	0.1	1.5	3.1	-0.4	1.4	2.0	1.0	1.3	0.9	-0.1	1.7	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	-0.9	0.7	0.2	0.4	-0.6	0.2	-1.4	0.4	0.1	1.4	0.0	-0.4
Smoking status: Current	0.4	0.6	1.7	-1.3	-0.2	-0.4	0.2	0.5	-0.5	1.0	-0.6	-0.8	-0.8	-1.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.0	-1.2	-1.1	-1.4	-1.7	-1.3	-0.5	0.1	-0.4	0.2	0.2	-0.7	0.3
Whole body water mass	0.7	4.0	16.6	2.5	-1.9	-3.2	1.1	-4.1	-0.9	-2.0	-1.2	-1.2	-0.2	-1.5	-0.3
Leg predicted mass (right)	0.7	3.9	14.7	2.8	-1.8	-2.8	1.6	-3.8	-0.6	-2.1	-1.4	-1.4	-0.5	-1.3	-0.7
Arm fat mass (left)	0.8	3.2	11.3	3.4	-1.8	-1.0	2.0	-2.2	-0.8	-1.1	-1.9	-1.8	-0.9	-2.2	0.0
Number of self-reported non-cancer illnesses	1.2	2.0	6.4	1.2	0.5	1.3	1.8	2.5	1.3	-1.3	-0.8	-0.5	-1.4	1.7	-1.4
Average weekly champagne plus white wine intake	0.4	0.6	1.3	1.0	0.9	-0.8	0.7	-0.8	0.4	0.5	1.1	0.8	1.0	-0.0	0.1
Miserableness	0.6	1.1	2.9	0.7	-1.6	1.5	0.1	-0.5	-1.7	-0.8	-0.8	-0.5	-0.3	0.8	1.4
Guilty feelings	2.1	3.1	9.1	2.5	-1.8	1.2	0.8	0.2	-1.5	-2.5	-3.0	-1.7	-1.6	-1.5	-0.6
Wears glasses or contact lenses	0.9	1.0	3.5	-0.2	1.2	-1.1	0.7	1.9	1.2	-1.2	-0.2	-0.1	-0.7	1.2	-1.0
Ever taken oral contraceptive pill	1.5	1.7	4.1	0.9	-1.3	-1.4	0.3	-1.0	-1.4	-1.2	-1.1	-1.9	-0.9	-1.0	-2.0
Hearing aid user	0.5	0.5	2.0	0.7	1.4	-1.1	1.2	0.7	0.6	-0.1	0.3	0.4	0.3	-0.0	0.1
Mother’s age at death	0.6	0.7	2.9	-1.7	1.1	-0.4	-0.8	-0.4	0.8	0.5	1.0	0.7	0.5	1.0	0.2
Financial situation satisfaction	1.2	1.5	14.1	0.7	0.6	3.8	0.4	1.0	0.3	-0.9	-0.1	0.0	0.3	0.4	-0.1
Tinnitus: Yes, now most or all of the time	2.4	2.8	6.7	-1.1	1.4	-0.6	-0.4	0.6	0.8	1.4	2.5	2.6	2.2	2.3	2.1
Commuting to job workplace: Public transport	1.0	1.2	4.7	0.9	-1.0	1.0	0.3	-1.5	-0.3	1.0	-1.0	-0.9	-1.0	-2.2	-1.0
Eye problems/disorders: Glaucoma	0.8	0.9	3.2	1.3	-0.0	-0.3	0.4	0.5	-0.2	-1.2	-1.6	-1.1	-0.6	-1.8	-0.3
Medication: Blood pressure	0.3	0.5	1.4	1.1	-1.1	-0.2	-0.3	0.2	-0.2	-0.8	-1.2	-0.6	-0.9	-0.5	-0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.7	6.8	0.9	1.0	-1.5	2.1	2.6	1.8	-0.3	-0.1	0.1	-0.2	-0.5	-0.8
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.2	-1.7	1.4	0.8	-1.3	1.8	1.0	-1.3	1.1	1.0	1.6	0.9	0.5
High cholesterol (Self-reported)	2.1	3.7	15.1	3.5	0.6	-1.3	3.9	2.0	2.2	-0.0	0.2	1.4	-0.0	2.0	0.3
Medication: Bendroflumethiazide	0.9	1.4	3.7	-0.0	-1.2	1.6	-0.8	-0.2	-0.2	-1.9	-1.1	-1.1	-1.3	1.6	-1.1
Medication: Paracetamol	0.2	0.3	0.9	0.3	0.4	-1.0	0.7	-0.8	-0.0	-0.1	-0.5	-0.1	0.1	-1.0	0.2
Medication: Lisinopril	0.5	0.7	3.6	-0.2	0.4	1.5	0.2	1.2	1.9	0.5	0.2	0.6	-0.2	-0.0	-0.3
Medication: Atorvastatin	0.1	0.1	0.7	0.7	0.1	-0.8	0.3	-0.2	0.0	-0.4	-0.3	-0.2	0.1	0.0	0.3
Illnesses of father: High blood pressure	0.2	0.3	1.2	1.1	0.1	1.0	0.3	0.9	-0.2	0.2	0.3	0.2	0.3	-0.3	0.3
Alcohol drinker status: Never	0.2	0.3	1.4	0.0	0.2	0.2	-0.4	-0.1	-0.5	-0.2	-0.3	-0.1	0.7	-1.0	1.2
Ever smoked	0.6	1.0	6.0	-0.7	1.0	0.8	0.2	2.5	-0.7	-0.5	0.6	-0.1	0.2	1.5	-0.1
Basal metabolic rate	0.7	4.1	16.0	2.8	-2.0	-2.9	1.3	-4.0	-0.9	-1.9	-1.4	-1.4	-0.3	-1.8	-0.2
Leg fat percentage (left)	0.5	1.8	8.2	2.9	-1.0	0.1	1.8	-0.2	-0.4	0.1	-1.5	-1.2	-1.0	-2.0	0.1
Arm fat-free mass (left)	0.7	3.4	11.8	2.6	-1.9	-2.8	0.9	-3.4	-1.3	-1.8	-1.2	-1.1	0.0	-1.6	0.2
Number of operations (self-reported)	0.3	0.5	1.4	0.8	0.1	-0.3	1.2	0.8	0.6	-0.4	-0.3	-0.6	-0.9	0.5	-1.0
Average weekly beer plus cider intake	1.9	2.7	7.3	-0.8	2.2	0.5	1.2	2.6	2.0	2.7	1.7	1.4	0.4	1.4	0.9
Irritability	0.8	1.3	4.8	1.3	0.7	0.6	1.6	1.2	2.2	0.6	0.7	1.4	0.2	1.1	0.1
Risk taking	0.2	0.3	1.1	0.4	0.2	-0.5	0.7	1.0	-0.4	0.4	0.2	0.1	-0.2	0.9	-0.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.4	-1.9	0.1	-1.4	-1.6	-0.4	-0.1	-0.6	-0.2	-0.2	0.5	-1.5	0.4
Fractured/broken bones in last 5 years	1.2	1.5	4.8	-1.7	0.9	-0.4	-1.4	1.0	-0.5	1.2	1.2	1.1	1.4	0.6	2.2
Age started oral contraceptive pill	1.6	2.0	4.7	1.6	-2.0	-0.6	0.8	-1.8	-2.2	-1.2	-1.5	-1.5	-1.3	0.6	-0.7
Diastolic blood pressure, automated reading	0.7	2.0	4.9	1.3	-1.5	-1.1	-0.0	-0.3	-0.4	-1.7	-2.0	-2.2	-1.9	-0.7	-1.8
Ever depressed for a whole week	0.2	0.2	1.0	-0.7	0.1	0.5	-0.2	0.0	0.2	1.0	0.1	0.3	-0.6	0.6	0.3
Unable to work because of sickness or disability	0.2	0.3	1.1	0.8	-0.0	0.1	0.3	0.7	-0.1	-1.0	-0.5	-0.7	-0.4	0.1	-0.5
Commuting to job workplace: Cycle	0.3	0.3	1.6	0.0	0.3	0.1	-1.0	0.3	-0.4	-1.3	-0.2	-0.6	0.3	-0.5	-0.2
Myopia	1.5	2.2	8.4	2.7	0.7	0.4	2.9	0.7	1.8	1.0	-0.4	0.4	-1.6	1.0	-1.3
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.0	-2.0	-0.2	-1.4	-1.5	-2.0	-1.9	1.3	1.1	0.3	1.3	-0.4	1.9
Cholesterol lowering medication	1.6	2.4	5.7	1.8	1.5	-0.3	1.6	1.2	2.0	0.1	1.6	2.0	1.3	2.4	0.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	3.1	-0.5	1.7	-1.3	0.7	0.9	1.2	1.8	1.1	1.3	0.4	0.7	0.9
Pain experienced in last month	0.6	0.9	3.0	-0.7	-0.6	0.9	-1.7	-1.7	-0.8	-0.6	-0.3	-1.1	-0.5	-0.4	-1.0
Supplements: Calcium	0.5	0.6	5.6	0.2	-0.4	2.4	-0.5	0.1	-0.6	0.1	-0.5	-0.1	0.1	-0.4	0.6
Basal cell carcinoma (self-reported)	0.8	0.9	2.3	-0.6	-0.5	-1.1	0.2	-0.0	-0.4	-0.9	-0.8	-1.3	-1.5	1.3	-1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	5.3	1.7	0.2	-0.6	2.3	0.9	0.8	-0.5	-0.3	-0.3	0.0	-1.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.1	1.1	-0.4	-0.9	1.8	-0.5	0.4	-0.5	-1.0	-1.1	-1.1	-0.6	-0.8
Heart disease (siblings)	1.2	1.5	4.5	0.7	-0.2	-2.1	1.3	0.3	0.4	-1.6	-1.1	-1.5	-1.1	-0.7	-1.8
Alcohol drinker status: Previous	1.5	1.7	3.2	-0.2	1.4	0.9	-1.1	1.0	0.7	0.9	1.8	1.7	1.7	1.8	1.4
Pack years of smoking	0.9	1.3	3.5	1.7	0.4	0.1	1.7	-0.2	1.2	-1.3	-0.9	-1.0	-0.2	-1.9	-1.3
Impedance of whole body	0.4	1.8	5.2	-0.1	1.0	1.7	1.3	2.3	1.3	2.1	0.4	0.6	-1.1	1.6	-0.5
Leg fat mass (left)	0.6	2.4	8.5	2.9	-1.4	-1.2	1.8	-1.6	-0.9	-0.5	-1.5	-1.4	-0.7	-2.2	0.3
Arm predicted mass (left)	0.6	2.9	10.7	2.2	-1.7	-2.6	0.6	-3.3	-1.2	-1.6	-1.0	-1.1	0.1	-1.6	0.2