Hub : Genes

AC004381.6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0860	0.0370	0.00150	0.041	NA	0.016	NA	0.003	2.7e-04	NA	0.01600	NA	0.17000
2	GTEx	Artery Tibial	0.1121	0.0437	0.00300	-0.003	NA	0.011	NA	-0.003	6.2e-01	NA	0.04000	NA	0.68000
3	GTEx	Brain Cerebellar Hemisphere	0.3000	0.1080	0.00450	0.063	NA	0.004	NA	0.023	1.1e-02	NA	0.25000	NA	0.08200
4	GTEx	Brain Cerebellum	0.2290	0.0760	0.00032	0.090	NA	0.122	NA	0.009	1.3e-03	NA	0.00019	NA	0.17000
5	GTEx	Testis	0.1810	0.0780	0.00330	0.101	NA	0.064	NA	0.082	3.2e-05	NA	0.00081	NA	0.00018
6	ROSMAP	Brain Pre-frontal Cortex	0.0829	0.0365	0.00350	0.002	0.014	0.021	0.021	0.007	1.6e-01	0.0061	0.00081	0.00098	0.03900

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	1.0	-0.5	0.3	-0.2	0.2	-1.0	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.2	3.8	0.3	1.2	0.4	1.1	-0.5	-2.0
Depressed Affect (Nagel 2018)	0.3	0.6	2.5	0.0	-0.4	0.8	1.6	0.5	-0.3
Depression (Nagel 2018)	0.5	0.7	1.4	-1.0	-0.4	1.2	0.8	0.4	0.9
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.1	-1.2	-2.3	0.0	-1.2	-0.4	-0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-0.1	-0.4	1.0	0.5	0.6	-0.2
Schizophrenia (2018)	0.5	1.1	3.1	0.8	0.9	0.7	1.3	0.2	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	1.6	0.3	-0.7	1.3	0.7	1.2	1.3
Worry (Nagel 2018)	0.4	0.8	1.8	-0.8	-1.3	0.8	-0.8	1.0	0.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.2	-1.1	0.7	-0.3	-0.3	-1.5	-0.4
Alzheimer’s Disease (in father)	0.7	0.7	2.0	-0.5	-1.4	1.2	0.6	-0.0	0.6
Alzheimer’s Disease (including proxy)	1.2	1.8	4.8	-2.2	-1.2	0.1	-1.1	-1.8	-0.1
Crohns Disease (2017)	0.9	2.0	4.7	-1.8	-0.0	-1.1	-2.2	-1.3	-1.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.0	-1.2	-0.3	-1.1	-1.4	-0.7	-0.5
Ulcerative Colitis (UC)	0.2	0.5	1.4	-0.6	-0.5	-1.2	-0.4	-0.8	-0.2
Major Depression (MDD)	0.7	0.9	2.5	1.1	-1.1	0.3	1.6	-0.3	0.4
Reaction Time	1.5	2.9	6.3	1.1	-1.8	2.1	2.5	1.3	-0.3
Verbal and Numeric Reasoning (VNR)	1.5	3.6	6.4	-2.5	-2.4	-1.2	-2.0	-1.3	1.6
Breast Cancer	0.7	1.7	4.0	-2.0	0.5	-1.6	-1.1	-1.4	-0.3
Ovarian Cancer	0.4	0.5	2.4	0.0	0.7	-0.3	0.4	0.0	1.6
Prostate Cancer	0.4	0.5	1.9	-0.3	0.1	-1.0	0.4	-0.4	1.4
Age at First Birth	0.2	0.3	0.7	-0.7	-0.1	-0.1	-0.8	-0.9	0.1
Bipolar Disorder (2011)	1.4	1.4	3.5	-1.8	-0.8	0.6	-1.9	-0.7	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.7	1.6	-0.1	1.3	1.5	0.4	-0.5
Coronary Artery Disease (CAD)	1.7	2.0	3.4	1.8	1.4	1.4	1.2	1.7	0.7
Crohns Disease (2012)	1.5	2.5	5.4	-1.6	-1.6	-1.0	-2.3	-1.8	-0.5
Mean Putamen Volume	0.5	0.5	2.6	0.4	-0.1	0.5	-0.3	1.6	0.1
Fasting Glucose	1.3	1.6	4.4	-2.1	0.4	0.4	-1.6	-0.7	1.3
HbA1C	0.6	0.7	1.6	-0.0	-0.9	0.3	-0.9	-0.9	-1.3
HDL Cholesterol	0.3	0.6	1.2	-0.7	-0.8	0.9	0.4	1.1	0.5
LDL Cholesterol	0.3	0.5	1.2	-0.2	-0.8	1.0	-0.2	-0.2	-1.1
Lupus	1.4	2.0	5.2	-0.8	1.4	-2.3	-1.3	-0.9	-1.3
Neuroticism (2016)	0.2	0.2	0.8	0.0	0.1	0.7	0.9	0.1	0.3
Primary Biliary Cirrhosis	0.3	0.4	1.1	-1.0	0.4	-0.4	-0.7	0.7	-0.5
Rheumatoid Arthritis	0.1	0.2	0.5	-0.7	-0.1	-0.1	-0.7	0.3	-0.2
Schizophrenia (2014)	0.3	0.8	1.5	0.5	-0.1	1.2	1.2	0.2	-1.2
Triglycerides	0.1	0.2	0.7	-0.5	-0.8	0.6	-0.1	0.2	0.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.8	-1.1	1.3	-0.9	-1.7	0.2	-1.3
Ulcerative Colitis	0.4	0.5	1.6	-0.6	-1.3	-0.4	0.0	0.7	0.8
Blood Eosinophil Count	0.7	5.1	15.6	-3.4	0.2	0.5	-4.0	1.2	1.1
Blood Platelet Count	0.7	8.2	31.6	2.5	1.9	1.2	5.6	0.3	2.5
Blood Red Count	0.8	8.1	19.4	-3.6	0.8	-3.0	-4.4	-2.1	-1.5
Blood White Count	0.3	2.5	4.7	1.5	1.8	0.7	2.2	1.1	1.8
Heel T-Score	0.7	5.4	12.5	3.4	-0.8	2.0	3.5	2.0	0.0
BMI	0.3	1.7	8.7	-0.4	-0.0	0.4	0.5	-0.9	-3.0
Height	1.2	23.1	51.6	-6.0	-1.1	-4.3	-5.3	-7.2	-1.7
Waist Hip Ratio (WHR)	1.3	5.7	11.4	-1.5	3.2	-3.4	-2.5	-1.5	-1.0
Systolic Blood Pressure	2.6	13.2	31.9	5.2	0.8	1.6	5.7	3.8	1.6
Smoking Status	1.5	3.7	7.0	-1.5	0.5	-1.2	-2.4	-2.6	-2.3
Allergy or Eczema	0.3	0.8	1.7	1.1	-0.5	-1.0	0.7	-0.6	-1.3
Cardiovascular Disease	2.2	7.1	18.6	4.3	-0.3	2.1	3.6	2.6	0.4
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.6	0.1	-0.6	0.6	1.0	0.9
Respiratory disease	1.4	3.2	5.7	-2.0	1.2	-2.0	-1.9	-2.4	-0.8
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.3	0.7	1.1	1.5	1.1	2.1	0.6
Lung FEV1/FVC ratio	0.1	0.7	1.2	-0.8	-1.0	1.1	0.7	-0.1	-0.8
Lung FVC	0.7	3.5	10.5	0.5	-2.1	-3.2	-0.2	-2.2	1.0
Neuroticism	0.4	0.8	2.0	0.3	-0.2	1.4	1.4	1.0	0.1
Chronotype (morning person)	0.5	1.2	4.2	0.4	1.4	-0.9	-0.2	-0.3	-2.0
Hair Pigment	0.0	0.1	0.2	0.1	-0.4	-0.2	0.0	-0.4	-0.2
Tanning	0.1	1.2	1.8	-1.1	-0.6	-1.2	-1.4	-0.9	-1.1
Hand grip strength (left)	0.0	0.1	0.3	-0.4	0.1	-0.5	-0.1	0.1	-0.2
Number of treatments/medications taken	1.1	1.9	4.2	1.5	1.5	-0.4	2.0	1.5	-0.4
Average weekly spirits intake	0.6	0.8	3.1	-0.1	-0.0	-1.8	-0.8	-0.5	-0.7
Sensitivity / hurt feelings	0.3	0.5	0.9	0.8	0.5	0.5	0.9	1.0	-0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.7	-0.4	-1.9	1.5	1.0	-0.6	1.1
Hearing difficulty/problems: Yes	0.1	0.2	0.6	-0.1	0.7	0.2	0.1	0.7	0.1
Relative age of first facial hair	0.5	1.0	2.6	-0.0	0.4	0.4	1.6	0.8	1.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.5	-1.8	-0.0	-1.9	-1.0	-1.6	0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.1	-0.5	-0.3	1.8	0.7	0.7	-1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.8	-0.2	0.2	-0.5	-0.6	-0.0
Systolic blood pressure, automated reading	0.7	2.1	8.1	1.6	-0.0	-0.1	2.8	0.9	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.9	0.1	0.3	0.9	0.6	1.7	-1.2
Angina	2.3	3.1	15.3	-0.6	-0.8	3.9	0.2	1.3	0.6
Medication for hormone replacement therapy	0.4	0.5	2.0	-0.2	1.4	0.3	0.0	-0.2	0.8
Vitamin and mineral supplements	0.4	0.6	1.7	1.3	-0.9	0.1	0.7	-0.3	0.6
Supplements: Zinc	0.5	0.5	1.1	0.5	-0.2	-0.2	1.0	0.9	-1.0
Medication: Co-codamol	0.8	1.0	1.7	-1.0	-1.3	-1.1	0.2	-1.2	0.7
Medication: Metformin	0.7	0.9	2.3	-0.4	1.3	0.5	0.1	1.5	1.2
Diabetes (father)	0.7	0.9	3.9	0.0	0.2	-0.7	-0.5	0.8	2.0
Diabetes (mother)	1.4	1.8	7.3	0.2	2.7	0.2	0.8	0.9	-1.4
Severe depression (siblings)	0.6	0.7	1.5	1.2	-0.2	0.0	1.2	0.7	-0.6
Pack years adult smoking proportion	0.3	0.5	1.1	-0.7	1.1	0.2	-0.8	0.9	-0.0
Impedance of leg (right)	0.1	0.5	1.8	0.1	0.7	-0.2	-0.9	1.3	0.3
Leg fat-free mass (left)	0.8	4.2	13.1	-2.5	-0.8	-1.4	-1.7	-3.6	-0.4
Trunk fat percentage	0.1	0.5	1.6	0.2	1.2	0.0	0.3	-0.1	-1.2
Hand grip strength (right)	0.1	0.2	0.4	-0.6	0.4	-0.6	-0.2	0.4	-0.2
Townsend deprivation index at recruitment	0.2	0.2	0.6	0.3	0.1	-0.5	0.3	-0.8	-0.6
Current tobacco smoking	1.2	1.9	4.0	-1.2	-0.5	-0.3	-1.7	-1.7	-2.0
Average weekly fortified wine intake	0.9	1.1	2.6	-1.2	0.9	-0.4	-1.2	0.5	-1.6
Maternal smoking around birth	1.8	2.6	4.8	-1.2	-0.4	-2.2	-2.2	-2.1	-0.4
Fed-up feelings	0.1	0.2	0.4	-0.3	-0.6	0.3	0.2	-0.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	-0.6	0.4	0.1	1.1	-0.6	0.6
Relative age voice broke	0.7	1.1	3.6	0.1	-1.9	-0.2	1.6	-0.0	0.6
Taking other prescription medications	0.2	0.3	1.3	0.2	1.1	-0.8	0.4	0.1	0.0
Age when periods started (menarche)	1.2	2.9	9.4	1.7	1.1	0.6	1.7	3.1	0.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.1	-0.1	0.2	2.0	0.3	1.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	9.3	2.2	-0.9	-0.5	3.1	-1.0	2.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.8	-1.0	-0.5	0.7	-0.0	0.2	1.7
Qualifications: CSEs or equivalent	1.2	1.6	5.0	1.2	2.2	-1.7	0.3	-0.3	0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.6	0.7	0.5	1.2	0.8	0.6	0.2
High blood pressure	2.1	5.9	11.9	3.4	-1.3	2.4	3.3	2.3	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.3	0.7	-0.1	-1.1	0.4	-0.5	-0.3
Multivitamins +/- minerals	0.2	0.3	0.7	-0.8	0.5	0.4	-0.0	0.4	-0.7
Stomach or abdominal pain in last month	1.4	1.7	4.7	2.2	-1.3	1.3	1.3	0.1	-0.5
Supplements: Glucosamine	0.7	0.9	4.4	-2.1	-0.4	-0.7	-0.2	-0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.8	-0.5	0.1	-1.9	-0.7	-1.0	0.7
Medication: Atenolol	1.5	1.8	6.0	0.2	-0.6	2.4	0.9	1.9	0.4
Medication: Levothyroxine sodium	0.9	1.5	4.2	-0.0	1.1	-0.6	1.3	1.2	2.0
Sitting height	3.0	21.1	47.2	-5.9	-1.6	-3.9	-5.2	-6.9	-0.2
Chronic bronchitis/emphysema (father)	0.7	0.9	2.2	1.5	0.5	-0.2	0.7	-1.4	-0.3
High blood pressure (mother)	1.9	2.7	7.0	2.6	0.4	0.7	2.3	1.7	0.8
Body mass index (BMI)	0.1	0.5	1.5	-0.1	0.0	0.6	1.1	-0.2	-1.2
Impedance of leg (left)	0.1	0.5	1.3	-0.3	0.4	-0.7	-1.2	0.8	0.2
Leg predicted mass (left)	0.8	4.1	13.0	-2.5	-0.9	-1.4	-1.6	-3.6	-0.5
Trunk fat mass	0.2	0.8	2.0	-0.7	0.5	-0.4	-0.3	-1.3	-1.4
Waist circumference	0.4	1.4	3.1	-1.0	1.4	-0.7	-0.7	-1.1	-1.8
Number of incorrect matches in round	0.7	1.1	2.2	1.0	0.3	1.1	1.5	1.3	-0.5
Past tobacco smoking	0.7	1.3	4.8	0.7	-0.1	0.8	1.1	2.2	0.7
Alcohol usually taken with meals	0.5	0.8	2.7	-1.6	0.5	-0.6	-1.1	0.6	-0.2
Nervous feelings	0.3	0.5	1.5	-0.3	-0.8	0.6	-0.6	1.2	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.4	-1.2	0.4	1.2	-0.6	-0.9
Hearing difficulty/problems with background noise	2.0	3.3	9.4	2.6	-0.2	1.5	3.1	0.8	0.7
Hair/balding pattern: Pattern 2	1.0	1.3	5.4	0.3	1.2	-2.3	-0.8	-0.1	0.6
Had menopause	1.3	1.6	6.4	-0.2	-2.5	1.7	-0.2	0.3	0.2
Had other major operations	0.3	0.4	2.0	0.2	-1.4	0.3	0.2	-0.6	-0.1
Forced vital capacity (FVC)	1.2	4.5	14.0	-1.3	-1.5	-2.7	-1.2	-3.7	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	6.2	2.0	-0.5	-0.0	2.5	-0.6	1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	0.7	0.6	0.3	0.7	0.6	-0.7
Qualifications: None of the above	0.2	0.4	1.1	0.8	0.1	-0.5	1.0	-0.5	-0.5
Financial difficulties in last 2 years	0.6	0.8	2.1	0.7	-0.2	-0.4	1.0	-1.4	-1.0
Mouth/teeth dental problems	0.5	0.8	2.2	-0.7	-0.9	1.5	-0.8	0.8	0.6
Heart attack	0.4	0.5	1.0	0.6	1.0	0.5	-0.7	0.5	-0.7
Allergy	0.6	1.3	3.1	-0.1	-1.5	1.8	0.1	1.3	0.8
Pain all over the body in last month	0.9	1.0	2.3	-1.5	-1.2	0.1	-0.1	-1.5	-0.2
Diabetes (self-reported)	0.7	1.2	3.3	0.1	1.1	1.8	0.4	1.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.6	1.2	-0.8	1.1	1.1	1.3	1.2
Medication: Ramipril	1.1	1.4	2.5	1.0	-1.5	0.5	1.4	0.6	1.6
Medication: Simvastatin	0.4	0.6	2.2	0.7	0.5	0.0	0.7	1.5	0.4
Fluid intelligence score	0.8	1.6	4.0	-1.7	-2.0	-0.1	-1.3	-0.5	0.9
Illnesses of siblings	1.5	2.1	6.0	-1.1	1.9	-0.8	-2.4	-0.9	-0.5
Neuroticism score	0.4	0.9	2.0	0.8	-0.4	1.2	1.4	0.7	0.7
Weight	0.6	3.0	8.1	-2.3	-0.4	-0.9	-1.1	-2.8	-1.6
Impedance of arm (right)	0.5	2.3	6.2	1.3	1.9	1.1	0.3	2.5	0.9
Arm fat percentage (right)	0.2	0.8	2.2	0.6	0.9	0.7	1.5	0.7	-0.8
Trunk fat-free mass	2.1	12.3	29.7	-4.6	-2.2	-2.5	-3.2	-5.5	-1.0
Hip circumference	0.2	0.7	2.0	-1.0	-0.2	0.6	0.1	-1.0	-1.4
Time employed in main current job	1.2	1.4	4.1	-0.1	-2.0	0.2	0.2	0.6	2.0
Alcohol intake versus 10 years previously	0.5	0.8	2.1	-0.2	1.0	-1.5	-0.3	-1.0	-0.6
Father’s age at death	0.5	0.7	1.5	-0.6	0.9	-0.2	-1.0	-0.6	-1.2
Worrier / anxious feelings	0.2	0.5	1.9	0.5	-1.4	-0.4	0.2	0.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.3	0.2	0.4	1.0	-0.1	0.7
Falls in the last year	0.7	0.9	2.0	0.8	0.0	-0.9	0.7	-1.4	-1.2
Hair/balding pattern: Pattern 3	1.0	1.4	2.4	-1.6	0.4	-1.4	-1.5	-1.4	0.1
Number of live births	0.6	0.9	2.8	1.7	-0.4	0.4	1.4	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	6.8	-0.9	-1.7	-1.6	-0.5	-2.6	0.7
Pulse rate	0.8	1.4	3.2	-1.8	1.8	-0.9	-0.4	-1.1	-0.3
Happiness	1.1	1.4	3.0	0.5	-1.4	1.4	1.7	0.4	0.7
Noisy workplace	0.6	0.7	1.4	-0.9	0.6	-0.4	-0.6	-1.0	1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	0.1	-0.4	0.2	-0.9	-0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.7	-0.8	0.2	0.7	0.4	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.9	0.4	-0.1	-0.3	1.0	-0.4	0.3
Asthma	1.4	2.8	6.0	-1.6	2.5	-2.1	-0.6	-1.6	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.3	-0.9	0.1	-1.8	0.0	-0.4	-0.4
Medication: Cholesterol lowering	0.5	0.8	2.4	1.5	0.6	0.4	0.5	1.2	0.3
Depression (self-reported)	0.5	0.6	1.6	-1.3	0.4	-0.7	-0.8	-0.5	0.4
Medication: Lansoprazole	0.8	0.9	3.6	0.6	-1.9	0.3	-0.0	-1.0	0.6
Prospective memory result	0.8	0.9	2.5	1.4	-0.6	0.7	0.2	0.5	-1.6
Lung cancer (father)	1.2	1.4	3.1	-1.2	0.7	-0.8	-1.8	-1.2	-1.1
Illnesses of mother	0.6	0.7	1.5	-1.2	-1.0	-0.2	-0.8	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	6.0	-0.5	-1.6	-1.7	-0.6	-2.4	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.8	0.0	1.3	-0.3	-0.4	0.5	0.1
Impedance of arm (left)	0.9	4.2	9.9	2.1	2.5	1.5	1.1	3.1	1.1
Arm fat mass (right)	0.2	0.7	2.3	-0.7	0.1	-0.0	0.3	-1.1	-1.5
Trunk predicted mass	2.1	12.2	29.5	-4.6	-2.1	-2.5	-3.3	-5.4	-1.1
Standing height	1.6	16.0	34.5	-5.0	-1.0	-3.5	-4.7	-5.9	-0.7
Length of working week for main job	1.5	1.6	6.3	-1.3	-1.0	-0.0	-0.3	-0.8	2.5
Exposure to tobacco smoke at home	0.7	0.8	1.7	-0.5	-1.3	-0.7	-0.9	-1.1	-0.6
Breastfed as a baby	2.2	2.7	5.5	1.5	-2.0	2.3	1.7	1.1	-0.5
Tense / ‘highly strung’	0.2	0.4	1.1	-0.3	-1.1	0.1	-0.9	-0.1	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.5	-0.1	-1.6	0.9	0.7	0.2	-1.2
Hair/balding pattern: Pattern 4	0.7	1.6	4.8	0.2	-1.6	2.2	1.4	0.7	-0.2
Birth weight of first child	0.7	1.3	3.0	0.9	1.6	0.4	0.9	1.7	0.5
Peak expiratory flow (PEF)	0.1	0.2	0.7	0.0	0.1	-0.1	0.4	-0.5	0.8
Pulse wave reflection index	0.6	0.8	2.7	1.1	0.4	0.1	0.5	1.6	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	0.8	-1.4	-0.0	0.2	-1.0	0.6
Loud music exposure frequency	2.4	2.6	6.4	-1.9	-2.5	0.7	-0.4	-0.8	2.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.4	0.2	-0.2	-0.2	0.7	0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	0.3	0.3	-0.8	-0.1	0.3	0.1
Blood clot in the leg (DVT)	1.3	1.7	4.1	1.6	2.0	-0.3	0.8	0.8	-1.5
Medication: Paracetamol	0.9	1.5	3.2	1.4	1.4	-0.3	1.8	0.8	-1.1
Headache pain in last month	0.2	0.4	0.9	0.3	1.0	-0.5	0.7	0.5	-0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.6	-2.1	-0.9	-0.2	-1.3	-2.0	-0.5
Glaucoma (self-reported)	1.7	2.0	6.6	-1.2	-0.9	-2.6	-0.9	-1.4	0.7
Gout (self-reported)	1.1	1.5	4.0	-1.0	-0.2	-1.2	-2.0	-1.2	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	-0.7	0.4	-1.0	0.5	0.9	1.4
Medication: Amlodipine	1.3	1.8	6.9	2.6	0.2	0.5	1.2	1.3	-0.7
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.6	0.6	1.0	-1.9	-0.8	-1.8	-1.2
Birth weight	0.8	1.7	2.8	-0.3	-0.5	-1.5	-1.5	-1.7	-1.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.4	-0.4	-0.4	0.1	-0.6	0.2	-1.2
High blood pressure (siblings)	0.8	1.2	2.1	1.3	-1.2	0.2	1.5	1.2	0.4
Forced vital capacity (FVC), Best measure	1.2	4.4	12.2	-1.4	-1.7	-2.7	-1.4	-3.5	-0.3
Body fat percentage	0.1	0.6	1.2	0.4	1.1	0.3	0.9	0.3	-1.1
Leg fat percentage (right)	0.2	0.6	1.6	0.3	0.3	0.5	1.0	0.6	-1.3
Arm fat-free mass (right)	1.9	9.8	24.8	-3.7	-2.5	-2.2	-2.7	-5.0	-1.4
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.1	0.4	0.9	0.8	0.8	-0.0
Comparative body size at age 10	0.6	1.7	4.0	0.8	-1.8	2.0	1.4	-0.5	-0.4
Number of full brothers	0.6	0.8	1.6	-0.3	-1.3	0.8	0.8	-1.0	-0.8
Worry too long after embarrassment	0.3	0.4	1.6	0.0	1.3	-0.4	0.9	0.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	-1.3	-0.9	-0.6	0.2	-0.8	-0.9
Wheeze or whistling in the chest in last year	0.3	0.6	0.9	0.9	0.7	0.2	1.0	-0.9	-0.7
Number of children fathered	1.8	2.0	5.1	1.4	0.8	-1.3	2.3	-0.9	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	7.6	1.3	-0.5	0.7	2.8	0.3	-0.2
Age at first live birth	1.0	1.7	6.7	-1.4	0.5	0.7	-0.5	0.8	2.6
Pulse wave peak to peak time	0.3	0.3	1.4	-0.2	-1.2	0.2	0.1	-0.7	-0.2
Health satisfaction	2.1	2.8	4.8	1.4	-1.5	2.2	1.7	0.1	2.1
Shortness of breath walking on level ground	0.1	0.2	0.6	-0.1	-0.2	-0.4	0.3	-0.8	0.1
Qualifications: College or University degree	0.2	0.5	1.4	1.1	0.3	1.2	0.2	-0.2	-0.3
Eye problems/disorders: None of the above	0.9	1.0	3.7	0.4	-0.9	0.5	0.6	0.8	1.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.9	2.2	0.9	0.6	0.9	0.4	-0.8
Emphysema/chronic bronchitis	0.7	0.8	1.3	-0.4	0.1	-0.8	-1.1	-1.1	1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	3.5	-1.2	-0.4	0.5	-1.9	-0.3	1.3
Neck or shoulder pain in last month	0.2	0.3	0.9	0.2	1.0	-0.1	-0.1	-0.7	-0.7
Medication: Blood pressure	1.4	2.5	8.1	2.9	-0.4	0.5	2.0	1.5	0.5
Angina (self-reported)	2.3	3.0	14.9	-0.6	-0.7	3.9	0.1	1.5	0.5
Migraine (self-reported)	0.5	0.6	3.0	0.0	0.3	-0.3	0.6	0.5	1.7
Medication: Ibuprofen	0.8	1.0	4.6	-1.0	0.3	-2.1	-0.0	-0.5	-0.2
Medication: Allopurinol	0.2	0.2	0.7	0.2	-0.4	-0.3	-0.8	0.2	-0.6
Medication: Omeprazole	1.0	1.1	4.9	0.8	-0.3	-0.4	0.9	0.5	-2.2
Medication: Seretide 50 evohaler	1.1	1.3	3.2	-0.2	1.8	-1.5	-0.7	-1.2	-0.7
Mean time to correctly identify matches	1.2	2.2	3.9	0.7	-1.9	1.7	2.0	1.0	-1.1
Heart disease (mother)	0.8	0.9	1.7	1.2	-0.2	0.7	1.3	1.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	5.5	1.2	0.7	2.4	1.0	1.9	-0.3
Whole body fat mass	0.2	0.7	2.0	-0.6	0.4	-0.3	-0.0	-1.1	-1.4
Leg fat mass (right)	0.1	0.5	1.3	-0.7	0.1	-0.2	0.1	-0.9	-1.1
Arm predicted mass (right)	1.8	9.4	24.7	-3.6	-2.0	-2.2	-2.7	-5.0	-1.5
Pulse rate, automated reading	0.5	1.7	4.2	-1.0	2.0	-1.5	-1.2	-0.4	-1.2
Alcohol intake frequency.	0.1	0.1	0.4	-0.2	0.4	-0.1	-0.1	0.3	0.7
Comparative height size at age 10	2.1	11.4	29.2	-4.1	-1.3	-2.1	-4.0	-5.4	-0.8
Number of full sisters	0.6	0.8	1.2	0.7	-0.9	0.7	1.1	0.6	-1.1
Suffer from ‘nerves’	0.3	0.5	1.3	0.4	-1.1	0.5	0.2	-0.5	1.0
Overall health rating	0.2	0.3	1.5	0.3	0.2	1.2	0.2	0.2	-0.6
Chest pain or discomfort	0.2	0.2	0.9	-0.5	0.9	0.3	-0.4	0.1	0.1
Had major operations	0.9	1.0	4.0	0.3	0.2	-0.5	0.3	-2.0	-1.3
Age at last live birth	1.2	1.7	8.8	-0.8	0.6	0.3	-0.5	0.2	3.0
Family relationship satisfaction	0.4	0.5	1.0	0.6	-1.0	0.8	0.4	0.5	-0.6
Leg pain on walking	0.5	0.6	1.2	0.6	-1.1	0.3	1.0	0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.7	1.2	0.9	1.3	1.3	1.1	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.1	0.9	1.1	-1.0	-0.1	-0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	8.4	-2.0	-0.9	-1.6	-2.9	-0.5	-0.0
Medication: Aspirin	0.6	0.8	2.9	1.0	-0.3	0.9	1.7	0.3	0.1
Supplements: Vitamin C	1.1	1.3	3.1	-1.3	0.4	-1.8	-0.8	-1.6	0.3
Knee pain experienced in last month	1.1	1.7	3.2	1.3	0.7	-1.2	1.8	1.0	-1.5
Hypertension (Self-reported)	1.9	5.2	10.5	3.2	-1.7	2.2	2.7	2.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	5.7	1.3	-0.8	-0.3	-0.5	-0.6	-2.4
Illnesses of father: Heart disease	0.4	0.6	2.3	-0.2	-1.5	0.3	1.0	0.3	0.4
Illnesses of siblings: Diabetes	0.5	0.7	1.1	0.2	1.0	-1.0	0.7	0.7	1.1
Smoking status: Previous	0.5	0.7	3.5	-0.1	0.1	-0.8	-0.1	-1.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.7	-1.8	0.9	-0.7	-1.2	-2.2	-0.2
Whole body fat-free mass	1.6	9.4	25.1	-3.9	-1.8	-2.3	-2.7	-5.0	-0.9
Leg fat-free mass (right)	0.9	4.6	14.1	-2.7	-0.9	-1.6	-1.7	-3.8	-0.3
Arm fat percentage (left)	0.4	1.4	3.2	1.0	1.1	1.2	1.8	1.3	-0.5
Average weekly red wine intake	2.6	3.8	8.0	-2.0	0.0	-1.8	-2.8	-1.8	-2.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.1	-0.9	0.9	0.3	0.8	-0.3
Mood swings	0.4	0.7	2.4	0.6	-0.5	-0.9	0.6	-0.1	-1.6
Loneliness, isolation	0.3	0.4	1.2	-0.5	-1.1	1.1	0.2	-0.2	0.1
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.9	0.8	-0.0	0.3	0.5	0.9
Ever had bowel cancer screening	0.6	0.7	1.6	1.3	0.8	0.7	0.5	0.6	-0.9
Diabetes diagnosed by doctor	1.2	2.0	4.3	0.7	1.7	1.7	0.9	2.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.2	0.0	1.1	0.1	0.2	-0.4	-0.1
Friendships satisfaction	1.4	1.7	8.6	0.2	-2.9	1.0	-0.6	-0.0	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.8	-0.2	0.1	-0.6	0.1	-0.2
Commuting to job workplace: Walk	0.1	0.2	0.4	0.1	-0.6	-0.2	0.1	0.1	-0.7
Eye problems/disorders: Cataract	1.3	1.6	6.2	0.6	1.2	0.2	-0.9	0.6	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	-0.6	0.2	-0.8	-0.3	-1.3	-0.8
Medication for cholesterol	1.3	2.0	3.8	-1.7	-1.4	-0.7	-1.7	-1.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-0.5	-0.1	-0.4	-0.3	-1.2	-1.3
Back pain experienced in last month	1.1	1.6	5.0	1.1	-1.8	-0.1	2.2	0.5	-0.2
Mineral and other dietary supplements	0.9	1.2	3.3	-0.8	-1.0	1.8	-1.5	-0.0	0.4
Breast cancer (self-reported)	0.7	0.8	2.0	1.0	1.4	-0.1	0.6	1.2	-0.5
Asthma (self-reported)	1.7	3.3	5.7	-1.7	2.4	-2.3	-0.8	-2.1	-0.8
Osteoporosis (self-reported)	0.3	0.4	1.3	-0.5	0.5	-0.1	0.3	-0.6	-1.1
Osteoarthritis (self-reported)	0.4	0.6	2.4	-0.1	0.1	-0.8	-0.5	0.1	-1.5
Medication: Aspirin	0.4	0.6	2.4	0.5	0.3	0.7	1.5	0.3	0.4
Medication: Gliclazide	1.5	1.7	3.7	0.3	1.8	0.2	1.1	1.4	1.9
Illnesses of father: None of the above (group 1)	1.2	1.5	4.2	-0.1	2.1	-0.6	-1.2	0.1	-1.7
Smoking status: Current	1.2	1.9	4.2	-1.0	-0.4	-0.4	-1.7	-1.7	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.8	0.7	-2.0	-0.2	0.8	-0.6	-0.9
Whole body water mass	1.6	9.3	24.9	-3.8	-1.8	-2.3	-2.7	-5.0	-0.9
Leg predicted mass (right)	0.9	4.6	14.0	-2.7	-0.8	-1.6	-1.8	-3.7	-0.3
Arm fat mass (left)	0.1	0.4	1.1	-0.2	0.2	0.2	0.7	-0.6	-1.1
Number of self-reported non-cancer illnesses	0.3	0.4	1.0	-0.1	0.8	-0.1	1.0	1.0	0.0
Average weekly champagne plus white wine intake	0.8	1.1	4.3	-0.1	-0.4	1.3	0.4	2.1	0.7
Miserableness	0.4	0.8	2.9	0.9	0.6	-0.0	1.7	-0.1	-0.7
Guilty feelings	1.0	1.5	3.4	1.9	0.1	1.5	1.7	0.6	-0.3
Wears glasses or contact lenses	1.4	1.6	5.1	-2.3	-0.3	0.8	-1.1	-1.2	-1.2
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.6	0.1	0.4	-0.2	0.4	-0.1
Hearing aid user	0.6	0.7	1.2	-1.1	0.4	-0.9	-0.7	-1.1	-0.5
Mother’s age at death	0.4	0.5	1.9	-1.4	-0.8	-0.1	-0.3	-0.8	-0.2
Financial situation satisfaction	0.4	0.5	0.8	-0.5	-0.9	-0.5	-0.5	-0.9	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	-0.7	-1.3	-0.4	0.4	-1.2	-0.4
Commuting to job workplace: Public transport	0.9	1.1	2.8	0.9	-0.9	1.7	1.5	0.3	-0.1
Eye problems/disorders: Glaucoma	0.4	0.4	2.0	-0.4	-0.1	-1.4	-0.0	-0.6	0.4
Medication: Blood pressure	0.8	1.5	2.4	1.3	-1.1	1.6	1.3	1.2	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	0.1	-0.9	0.2	0.5	-0.9	-1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.7	1.0	1.1	-1.6	0.9	-0.6	0.2
High cholesterol (Self-reported)	0.5	0.9	2.8	1.0	1.1	-1.7	0.4	0.4	-0.5
Medication: Bendroflumethiazide	1.3	1.9	5.5	2.3	-0.3	0.7	1.8	1.4	0.1
Medication: Paracetamol	1.2	1.8	3.3	0.8	1.8	-1.0	1.4	0.8	-1.8
Medication: Lisinopril	1.0	1.3	3.3	1.1	-0.4	0.9	1.8	1.5	-0.1
Medication: Atorvastatin	0.6	0.7	2.1	0.9	0.3	0.5	0.9	1.4	0.6
Illnesses of father: High blood pressure	1.1	1.4	5.4	0.4	-0.9	-1.0	0.9	-0.6	2.3
Alcohol drinker status: Never	0.1	0.2	0.5	0.5	0.0	0.2	-0.0	0.4	0.7
Ever smoked	1.2	2.1	5.4	-0.9	-0.4	-0.7	-1.8	-2.3	-1.5
Basal metabolic rate	1.4	7.8	21.3	-3.6	-1.4	-2.1	-2.3	-4.6	-1.0
Leg fat percentage (left)	0.1	0.4	1.4	0.1	0.2	0.3	0.9	0.3	-1.2
Arm fat-free mass (left)	2.1	10.8	27.9	-4.0	-2.0	-2.8	-2.7	-5.3	-1.6
Number of operations (self-reported)	0.5	0.8	1.6	0.7	1.2	-0.6	1.3	-0.5	-0.7
Average weekly beer plus cider intake	0.4	0.5	1.4	0.2	-1.0	0.7	0.0	-1.2	-0.4
Irritability	0.6	1.0	3.0	-1.3	-1.7	0.4	-0.6	-0.4	0.8
Risk taking	0.7	1.0	3.0	1.0	1.1	-0.2	0.6	-1.7	-0.8
Ever had prostate specific antigen (PSA) test	1.2	1.3	2.6	0.7	1.5	-1.6	-1.1	-0.7	-1.0
Fractured/broken bones in last 5 years	1.8	2.3	4.1	2.0	2.0	0.8	1.6	1.8	-0.1
Age started oral contraceptive pill	1.1	1.3	5.9	0.5	-0.5	1.0	-0.3	0.7	-2.4
Diastolic blood pressure, automated reading	1.6	5.1	13.0	3.3	0.4	0.9	3.6	2.4	0.1
Ever depressed for a whole week	0.5	0.6	1.5	1.1	0.6	-0.3	1.2	0.2	-0.9
Unable to work because of sickness or disability	1.1	1.4	4.4	-0.0	-2.1	1.6	0.6	-0.0	1.1
Commuting to job workplace: Cycle	0.4	0.4	0.8	-0.6	-0.8	0.7	-0.4	0.5	0.9
Myopia	0.3	0.5	2.0	0.5	-0.0	1.4	0.1	0.5	0.6
Vascular/heart problems diagnosed by doctor	2.1	5.6	11.4	-3.4	1.0	-2.7	-3.2	-2.0	-0.1
Cholesterol lowering medication	0.2	0.4	0.8	-0.4	-0.1	-0.9	0.8	0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	6.3	0.4	0.2	-0.8	-0.0	-0.5	-2.5
Pain experienced in last month	0.7	1.1	3.9	-0.8	0.9	-0.4	-2.0	-0.7	0.9
Supplements: Calcium	1.4	1.5	5.1	1.7	0.2	-0.5	2.3	0.0	-1.0
Basal cell carcinoma (self-reported)	0.8	0.9	3.1	1.3	0.3	-0.4	0.0	-1.8	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.6	0.5	0.7	0.5	-0.8	0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	3.0	1.7	1.7	-0.3	0.8	0.8	-1.3
Heart disease (siblings)	1.3	1.5	2.9	-0.1	-1.2	1.7	1.5	1.6	-0.3
Alcohol drinker status: Previous	0.1	0.2	0.4	-0.2	0.6	0.2	-0.6	-0.5	0.2
Pack years of smoking	0.3	0.4	0.8	-0.6	0.9	-0.2	-0.8	0.8	-0.3
Impedance of whole body	0.3	1.5	4.7	1.1	1.7	0.5	-0.3	2.2	0.3
Leg fat mass (left)	0.1	0.5	1.1	-0.8	-0.1	-0.2	0.0	-1.1	-1.0
Arm predicted mass (left)	2.2	11.3	28.2	-4.1	-2.1	-2.7	-2.8	-5.3	-1.7