Hub : Genes

AC016725.4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.272	0.0830	5.1e-05	0.182	NA	0.194	NA	0.238	2.0e-05	NA	1.1e-05	NA	8.3e-07
2	GTEx	Brain Cerebellum	0.499	0.0990	3.4e-07	0.179	NA	0.235	NA	0.191	5.6e-06	NA	1.4e-07	NA	2.6e-06
3	GTEx	Cells EBV-transformed lymphocytes	0.353	0.1350	6.0e-03	0.016	NA	-0.001	NA	0.027	9.6e-02	NA	3.4e-01	NA	4.7e-02
4	GTEx	Nerve Tibial	0.146	0.0566	1.2e-04	0.057	NA	0.010	NA	0.024	7.5e-05	NA	5.9e-02	NA	8.1e-03
5	GTEx	Prostate	0.267	0.0970	4.3e-04	0.030	NA	0.126	NA	-0.003	5.9e-02	NA	4.6e-04	NA	3.9e-01
6	GTEx	Testis	0.180	0.0640	7.8e-05	0.088	NA	0.082	NA	0.093	9.8e-05	NA	1.7e-04	NA	6.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.8	4.5	-1.1	0.1	-2.1	-2.0	-0.6	0.9
Bipolar Disorder or Schizophrenia	1.9	4.7	8.5	-2.1	-1.2	-2.3	-2.9	-1.8	2.3
Depressed Affect (Nagel 2018)	1.0	2.1	3.5	1.5	1.3	1.0	1.9	1.2	-1.7
Depression (Nagel 2018)	0.9	1.4	3.7	1.4	0.9	0.5	1.9	1.1	-0.7
Intelligence (Savage-Jansen 2018)	1.7	5.1	10.9	2.3	1.9	0.3	2.4	3.3	-2.3
Neuroticism (Nagel 2018)	1.3	3.2	5.8	1.5	2.1	1.0	1.9	1.4	-2.4
Schizophrenia (2018)	1.6	3.3	4.9	-1.9	-1.5	-1.2	-2.1	-1.8	2.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	-0.1	0.2	0.8	0.7	-0.5	-0.1
Worry (Nagel 2018)	2.9	6.1	10.5	2.1	3.2	1.4	2.0	2.3	-3.2
Alzheimer’s Disease (in mother)	4.0	4.7	10.5	-1.6	-2.4	-1.5	-1.8	-1.9	3.2
Alzheimer’s Disease (in father)	1.3	1.5	4.3	-0.5	-0.5	-1.6	-0.5	-1.1	2.1
Alzheimer’s Disease (including proxy)	6.1	8.9	19.7	-2.4	-2.2	-2.8	-2.3	-3.1	4.4
Crohns Disease (2017)	1.1	2.4	3.3	1.6	1.5	1.8	1.8	1.1	-1.4
Irritable Bowel Disease (IBD)	0.8	2.0	3.6	1.2	1.2	1.9	1.6	1.2	-1.1
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.3	0.6	0.9	0.7	0.9	-0.4
Major Depression (MDD)	1.7	2.0	4.4	1.6	2.1	0.7	1.8	-0.4	-1.1
Reaction Time	0.8	1.5	6.2	0.9	-0.3	2.5	1.1	0.3	-0.8
Verbal and Numeric Reasoning (VNR)	1.3	3.1	7.7	0.9	1.0	0.8	1.8	2.8	-2.3
Breast Cancer	3.0	7.3	12.8	-3.0	-3.6	-1.1	-3.0	-1.9	2.9
Ovarian Cancer	1.8	2.4	3.8	-1.9	-1.8	-0.4	-1.9	-0.9	1.6
Prostate Cancer	0.1	0.2	0.4	-0.6	-0.2	0.2	-0.6	0.2	-0.4
Age at First Birth	1.8	2.5	3.9	-1.4	-2.0	-1.8	-2.0	0.1	1.5
Bipolar Disorder (2011)	2.1	2.0	7.2	-0.7	0.2	-2.7	-1.4	-0.9	1.3
Body Mass Index (BMI) (2010)	2.1	2.9	6.1	0.6	0.6	2.4	0.6	2.1	-2.5
Coronary Artery Disease (CAD)	0.3	0.4	1.5	-0.1	1.2	0.6	-0.3	-0.4	-0.4
Crohns Disease (2012)	0.5	0.9	1.5	0.8	1.2	0.8	0.8	1.0	-1.0
Mean Putamen Volume	0.8	0.9	2.8	-0.6	0.8	-1.7	0.3	-1.1	0.4
Fasting Glucose	0.7	0.9	1.5	1.2	-0.0	1.1	0.8	1.2	-0.7
HbA1C	1.0	1.1	2.0	-1.3	-1.3	0.6	-0.9	0.5	-1.4
HDL Cholesterol	2.5	4.2	7.8	-1.0	-0.8	-2.6	-1.4	-2.6	2.8
LDL Cholesterol	4.7	7.4	10.7	-2.3	-3.3	-1.3	-3.1	-2.8	3.1
Lupus	2.6	3.9	7.3	2.2	1.2	1.7	2.0	2.7	-1.8
Neuroticism (2016)	4.2	6.0	12.2	1.4	2.8	2.5	2.1	1.9	-3.5
Primary Biliary Cirrhosis	1.1	1.6	3.8	1.1	1.0	-1.5	0.8	1.9	-0.9
Rheumatoid Arthritis	0.2	0.3	1.0	-0.1	-1.0	0.4	-0.5	-0.4	0.2
Schizophrenia (2014)	3.1	6.8	9.8	-2.8	-1.6	-2.4	-3.1	-2.5	3.0
Triglycerides	0.2	0.2	0.6	0.1	0.8	-0.1	0.3	0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	-0.4	0.3	-0.9	-1.0	-0.6	0.0
Ulcerative Colitis	0.5	0.7	2.2	0.5	-0.4	1.5	0.9	1.0	-0.2
Blood Eosinophil Count	1.1	8.8	11.8	-3.0	-2.9	-1.9	-3.4	-3.3	3.0
Blood Platelet Count	0.2	1.9	4.1	1.0	1.8	1.0	1.4	0.6	-2.0
Blood Red Count	6.2	60.3	104.4	6.8	5.6	7.7	7.2	8.4	-10.2
Blood White Count	0.1	0.7	3.3	-0.4	0.4	-1.8	-0.8	-0.3	-0.2
Heel T-Score	0.0	0.3	0.7	-0.4	0.8	-0.2	0.5	0.8	-0.5
BMI	1.8	10.3	15.6	2.8	3.8	2.4	3.7	2.2	-4.0
Height	0.2	4.1	14.3	-1.9	-3.8	-0.4	-2.1	-0.5	1.4
Waist Hip Ratio (WHR)	2.0	8.9	15.6	-4.0	-3.3	-1.4	-3.9	-3.0	0.9
Systolic Blood Pressure	3.5	17.5	21.8	4.7	3.5	3.4	4.7	4.1	-4.6
Smoking Status	1.8	4.2	6.9	-1.6	-2.6	-0.9	-2.5	-2.2	2.0
Allergy or Eczema	0.6	1.5	3.4	0.0	-1.2	-1.8	0.1	-1.1	1.9
Cardiovascular Disease	0.3	1.0	1.4	1.2	1.2	-0.5	1.1	0.3	-1.2
Hypothyroidism (self reported)	0.9	2.0	4.3	-1.9	-1.6	0.2	-2.1	-1.0	0.8
Respiratory disease	0.7	1.5	3.8	0.8	-0.7	-2.0	0.4	-1.1	1.7
Type 2 Diabetes (T2D) (2018)	3.6	6.8	8.9	-2.9	-2.4	-1.9	-3.0	-2.6	2.7
Lung FEV1/FVC ratio	0.3	1.6	2.7	-1.5	-1.3	0.7	-1.6	-1.2	0.9
Lung FVC	6.8	34.6	49.3	-5.2	-3.5	-6.9	-5.3	-6.5	7.0
Neuroticism	1.1	2.6	5.4	1.6	2.0	0.1	1.5	1.1	-2.3
Chronotype (morning person)	2.2	5.0	10.4	2.6	1.7	1.7	3.2	2.0	-1.8
Hair Pigment	1.0	29.2	79.0	-3.6	-3.6	-4.8	-3.5	-5.8	8.9
Tanning	0.2	2.0	4.8	-1.4	-2.1	0.5	-2.2	0.4	-0.5
Hand grip strength (left)	12.3	32.4	43.6	-5.7	-4.9	-4.0	-6.3	-6.2	6.6
Number of treatments/medications taken	0.3	0.6	0.9	-0.1	0.2	0.9	0.9	0.9	-0.9
Average weekly spirits intake	0.2	0.3	0.7	0.6	-0.3	-0.2	0.7	-0.4	0.8
Sensitivity / hurt feelings	1.3	2.2	5.5	1.2	2.0	0.6	0.9	1.1	-2.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	0.4	-0.1	-0.1	0.1	-0.2	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.8	0.2	0.1	-0.5	-1.0	-0.2
Relative age of first facial hair	5.0	10.3	19.4	-3.3	-3.7	-1.5	-4.4	-2.3	3.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.4	-0.8	-0.6	-1.4	-1.3	-2.3	1.6
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	-1.1	0.0	-0.9	-1.0	-0.9	0.7
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	0.8	-0.7	1.5	0.6	0.5	-0.7
Systolic blood pressure, automated reading	7.9	23.1	26.9	4.8	4.8	4.2	5.2	4.6	-5.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	-0.5	-0.5	-0.3	-0.5	-1.2	0.6
Angina	0.4	0.5	1.3	0.3	0.9	-0.6	1.1	0.1	-0.5
Medication for hormone replacement therapy	2.5	2.8	5.0	-1.5	-0.3	-2.2	-1.2	-2.2	1.7
Vitamin and mineral supplements	1.0	1.4	2.7	1.1	0.9	1.2	1.1	1.0	-1.6
Supplements: Zinc	0.1	0.1	0.2	-0.2	0.2	-0.5	0.4	-0.2	0.4
Medication: Co-codamol	0.6	0.6	1.2	-0.9	-0.8	1.1	-1.0	0.4	-0.2
Medication: Metformin	0.9	1.2	2.6	-0.6	-0.8	-1.6	-0.4	-1.4	1.3
Diabetes (father)	3.4	4.2	5.8	-2.3	-0.8	-2.0	-2.4	-2.4	1.9
Diabetes (mother)	0.9	1.2	3.1	1.8	0.2	-0.9	1.6	-0.3	0.8
Severe depression (siblings)	1.1	1.2	4.3	0.8	2.1	-0.3	0.9	1.2	-0.3
Pack years adult smoking proportion	5.2	8.0	16.4	3.1	4.0	0.1	3.6	2.2	-2.1
Impedance of leg (right)	0.4	1.8	4.7	-0.1	-1.3	2.2	-1.3	1.6	-0.6
Leg fat-free mass (left)	0.3	1.8	5.2	1.6	1.2	-0.6	2.3	0.2	-1.1
Trunk fat percentage	5.8	23.3	39.3	4.0	4.0	4.6	4.8	4.9	-6.3
Hand grip strength (right)	11.2	30.4	44.9	-5.4	-4.2	-4.0	-5.9	-6.4	6.7
Townsend deprivation index at recruitment	0.6	0.9	2.3	-1.5	0.3	-0.6	-1.1	-0.7	-0.9
Current tobacco smoking	0.4	0.7	1.3	-0.2	-0.8	-0.8	-1.1	-0.8	0.9
Average weekly fortified wine intake	1.0	1.2	4.0	-0.1	-0.3	-1.5	0.2	-2.0	0.9
Maternal smoking around birth	0.7	1.0	3.0	-1.1	-1.7	0.9	-1.0	-0.5	-0.1
Fed-up feelings	0.6	1.1	5.1	0.7	0.3	0.7	0.7	0.4	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.0	1.3	0.7	0.5	1.7	1.5	-1.1
Relative age voice broke	1.9	2.9	6.4	-1.8	-2.5	0.4	-2.5	-0.2	1.2
Taking other prescription medications	1.1	1.7	3.4	-1.8	-1.6	-0.3	-1.4	-1.3	0.7
Age when periods started (menarche)	1.4	3.4	7.8	-2.8	-1.8	-0.2	-2.6	-1.4	0.7
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	6.6	2.0	1.0	2.6	2.4	1.6	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.1	1.1	1.2	1.4	1.1	1.1	-1.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.0	-0.0	-0.7	0.2	-0.5	0.3
Qualifications: CSEs or equivalent	0.7	1.0	2.3	-1.1	-1.5	0.3	-1.5	-0.2	0.0
Serious illness, injury or assault to yourself	1.8	2.1	4.0	2.0	1.8	-0.2	0.7	2.0	-1.2
High blood pressure	3.6	10.1	16.0	2.8	2.7	2.2	3.2	3.8	-4.0
Hayfever, allergic rhinitis or eczema	2.0	4.3	7.6	-1.1	-1.7	-2.3	-1.4	-2.6	2.8
Multivitamins +/- minerals	0.5	0.6	1.4	-0.3	-0.6	-1.1	-0.7	-0.4	1.2
Stomach or abdominal pain in last month	1.7	2.2	4.8	-0.2	-1.9	-0.9	-0.9	-1.6	2.2
Supplements: Glucosamine	0.5	0.7	1.4	0.4	1.1	-0.4	1.2	1.1	-0.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.3	1.8	1.3	0.3	1.2	0.5	0.0
Medication: Atenolol	2.4	3.0	6.7	1.0	-0.1	1.5	1.5	2.5	-2.6
Medication: Levothyroxine sodium	0.9	1.6	2.7	-1.6	-1.5	-0.2	-1.6	-1.2	0.8
Sitting height	0.1	1.0	1.9	1.3	1.0	0.3	1.4	0.7	-1.0
Chronic bronchitis/emphysema (father)	2.9	3.4	4.5	2.0	2.1	1.4	2.1	1.7	-1.7
High blood pressure (mother)	4.6	6.4	12.7	3.3	2.5	1.2	3.6	1.9	-1.9
Body mass index (BMI)	3.0	12.8	20.1	3.5	3.9	2.7	4.5	2.4	-4.0
Impedance of leg (left)	0.5	2.3	6.7	-0.4	-1.5	2.6	-1.5	1.4	-0.5
Leg predicted mass (left)	0.3	1.8	5.5	1.6	1.2	-0.6	2.3	0.2	-1.1
Trunk fat mass	3.8	16.4	26.2	3.6	3.4	3.6	4.5	3.8	-5.1
Waist circumference	1.4	5.3	8.9	2.2	2.3	1.9	2.7	1.2	-3.0
Number of incorrect matches in round	8.3	13.8	19.6	-4.3	-1.6	-2.8	-4.4	-4.2	4.1
Past tobacco smoking	1.8	3.3	5.9	2.3	2.4	-0.1	2.3	1.5	-0.8
Alcohol usually taken with meals	1.3	2.1	6.3	-1.1	0.5	-2.5	-0.9	-0.7	1.9
Nervous feelings	3.1	5.8	8.2	2.5	2.6	2.1	1.8	2.4	-2.9
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	5.8	2.0	2.4	0.6	2.4	1.5	-2.2
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	0.5	-0.3	0.3	-0.7	-0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.2	-0.1	-0.1	0.1	0.2	0.5	-0.1
Had menopause	0.5	0.7	1.6	-0.6	1.0	-0.8	-0.2	-0.7	1.2
Had other major operations	1.1	1.3	3.4	-1.1	-0.2	-1.4	-0.9	-1.9	0.8
Forced vital capacity (FVC)	5.8	22.2	28.2	-4.4	-4.7	-4.4	-4.7	-4.7	5.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.8	1.1	2.2	-0.2	1.2	0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.4	0.3	1.2	-0.3	0.7	-0.7	-0.1
Qualifications: None of the above	0.9	2.0	6.1	0.5	1.1	2.5	0.6	1.3	-1.6
Financial difficulties in last 2 years	1.2	1.6	4.3	-0.5	-1.2	-2.1	-0.3	-1.3	1.2
Mouth/teeth dental problems	4.7	7.2	17.6	-2.1	-1.5	-4.2	-2.6	-2.4	2.5
Heart attack	0.2	0.3	0.6	0.2	0.5	-0.2	0.4	0.7	-0.8
Allergy	1.2	2.7	6.4	0.1	1.4	1.9	0.6	1.9	-2.5
Pain all over the body in last month	7.8	8.3	12.5	3.3	3.3	0.1	3.5	2.8	-2.9
Diabetes (self-reported)	0.7	1.1	1.9	-0.8	-0.9	-1.1	-1.0	-1.1	1.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	0.4	0.5	-1.1	0.9	-0.1	0.2
Medication: Ramipril	2.9	3.7	6.2	1.1	2.2	1.2	1.7	2.5	-2.4
Medication: Simvastatin	0.2	0.3	0.6	-0.8	-0.4	-0.4	-0.4	0.2	-0.8
Fluid intelligence score	0.1	0.3	0.8	0.3	0.2	-0.0	0.7	0.5	-0.9
Illnesses of siblings	3.9	5.4	7.6	-2.1	-1.9	-2.2	-2.2	-2.7	2.8
Neuroticism score	1.2	2.4	5.6	1.6	1.7	0.6	1.4	1.1	-2.4
Weight	1.3	6.3	11.0	2.7	2.1	2.1	3.3	1.7	-2.9
Impedance of arm (right)	0.3	1.3	4.3	0.1	-0.6	0.5	-0.6	2.1	-1.6
Arm fat percentage (right)	4.5	17.7	27.8	3.9	4.1	3.1	4.8	3.7	-5.3
Trunk fat-free mass	0.2	1.3	2.9	0.1	-0.6	-1.4	0.5	-1.7	1.6
Hip circumference	3.0	12.8	20.1	4.1	3.7	2.2	4.5	2.9	-3.6
Time employed in main current job	0.6	0.7	1.5	-0.0	1.0	-0.8	0.4	1.2	-1.1
Alcohol intake versus 10 years previously	0.4	0.6	2.6	-0.3	0.0	1.6	-0.3	0.8	-0.7
Father’s age at death	0.6	0.8	2.4	-0.8	-1.5	0.0	-0.7	-0.6	1.0
Worrier / anxious feelings	1.6	3.1	5.3	1.3	2.3	0.4	2.0	1.4	-2.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.7	1.2	0.6	-0.2	1.3	0.1	-0.9
Falls in the last year	0.3	0.4	1.4	0.5	-0.4	-1.2	0.2	-0.6	0.6
Hair/balding pattern: Pattern 3	1.6	2.4	3.3	1.6	0.8	1.7	1.5	1.7	-1.8
Number of live births	1.1	1.6	3.6	1.3	0.3	1.9	0.9	1.5	-1.1
Forced expiratory volume in 1-second (FEV1)	5.6	18.8	21.3	-4.4	-4.3	-3.6	-4.6	-4.4	4.6
Pulse rate	0.8	1.3	3.6	0.3	-0.0	1.9	0.7	1.1	-1.5
Happiness	0.2	0.2	0.5	0.1	-0.7	-0.4	0.5	-0.2	-0.4
Noisy workplace	0.6	0.7	1.3	0.7	0.7	1.1	0.5	1.0	-1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.6	2.0	1.4	-1.3	2.1	0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	-0.6	-0.9	-0.3	-1.1	-1.4	1.0
Mouth/teeth dental problems: Dentures	5.0	8.4	11.1	2.3	2.3	3.3	2.9	3.3	-3.0
Asthma	0.3	0.5	1.8	1.4	-0.1	-0.7	0.8	-0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.1	5.1	-1.8	-1.9	-1.9	-2.2	-2.1	2.3
Medication: Cholesterol lowering	0.7	1.0	2.6	-1.4	-0.8	-1.6	-1.0	-0.3	0.3
Depression (self-reported)	0.2	0.2	0.4	-0.6	-0.6	0.4	-0.5	-0.4	-0.3
Medication: Lansoprazole	0.7	0.8	2.2	0.9	1.5	-0.7	0.9	-0.9	-0.2
Prospective memory result	1.4	1.7	4.0	-1.3	-1.1	0.4	-0.9	-1.6	2.0
Lung cancer (father)	1.3	1.5	2.7	1.0	1.6	1.0	1.0	1.0	-1.6
Illnesses of mother	0.8	1.0	2.9	-1.1	-1.0	0.3	-1.7	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	4.8	15.2	20.8	-3.5	-3.2	-3.7	-4.0	-4.6	4.3
Pulse wave Arterial Stiffness index	2.2	2.6	5.5	1.3	0.8	1.8	1.1	1.8	-2.4
Impedance of arm (left)	0.3	1.5	5.2	-0.2	-0.6	0.5	-0.8	2.3	-1.7
Arm fat mass (right)	3.5	14.2	21.1	3.8	3.8	2.7	4.6	3.0	-4.4
Trunk predicted mass	0.2	1.3	2.9	0.1	-0.6	-1.4	0.5	-1.7	1.6
Standing height	0.3	2.6	8.6	-1.2	-2.9	-0.7	-1.6	-0.6	1.4
Length of working week for main job	2.7	3.0	5.5	-1.7	-1.6	-1.6	-2.4	-1.3	1.6
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.1	-0.1	0.5	-0.0	-0.4	-0.8
Breastfed as a baby	1.7	2.1	4.8	-1.6	-2.2	-0.2	-1.8	-1.1	0.8
Tense / ‘highly strung’	1.7	2.8	7.3	1.2	1.8	0.8	1.0	1.7	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.3	1.0	1.6	1.2	1.5	1.6	-2.1
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	-0.4	0.2	-0.8	-0.3	-1.1	0.7
Birth weight of first child	0.4	0.8	1.7	-1.3	-1.0	0.1	-1.1	-0.8	-0.1
Peak expiratory flow (PEF)	1.6	3.8	4.8	-2.0	-1.9	-1.8	-2.0	-1.8	2.2
Pulse wave reflection index	0.4	0.5	1.0	-0.2	-1.0	0.5	-0.7	-0.3	1.0
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.3	-0.9	-1.4	-0.4	-1.1	-1.1	1.5
Loud music exposure frequency	0.9	1.0	1.9	1.0	1.4	-0.3	0.1	0.9	-1.4
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	4.8	2.2	1.4	-2.2	2.0	0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.5	-0.6	0.1	-0.6	-0.9	0.7
Blood clot in the leg (DVT)	0.3	0.4	1.1	1.0	0.3	0.8	0.5	0.7	0.1
Medication: Paracetamol	0.0	0.0	0.1	0.3	0.1	-0.3	0.1	-0.1	0.2
Headache pain in last month	0.2	0.4	1.1	-0.4	-1.1	0.7	-0.1	-0.6	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	0.5	0.3	-0.0	-0.0	-0.8	1.0
Glaucoma (self-reported)	0.9	1.1	2.1	-1.1	-1.3	1.4	-0.7	-0.7	-0.8
Gout (self-reported)	0.2	0.2	0.5	-0.3	-0.3	-0.5	-0.4	-0.3	0.7
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	6.3	-2.2	-1.8	-0.8	-2.5	-1.3	1.4
Medication: Amlodipine	0.0	0.1	0.1	0.0	0.2	0.3	0.3	-0.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.7	-0.0	-1.1	-0.7	0.1	-1.6	0.7
Birth weight	2.1	4.5	7.3	-1.5	-1.9	-2.7	-1.0	-2.4	2.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-1.1	-1.0	1.4	-1.1	0.2	-0.6
High blood pressure (siblings)	4.5	6.5	10.2	2.4	1.5	3.1	2.0	2.7	-3.2
Forced vital capacity (FVC), Best measure	3.7	13.4	16.5	-3.2	-3.0	-3.8	-3.7	-4.0	4.1
Body fat percentage	5.8	23.1	37.0	4.2	4.1	4.6	4.9	4.7	-6.1
Leg fat percentage (right)	5.0	18.1	24.6	4.2	3.6	4.2	4.6	3.9	-5.0
Arm fat-free mass (right)	0.1	0.6	2.0	1.0	0.6	0.2	1.4	-0.4	-0.3
Exposure to tobacco smoke outside home	0.2	0.3	0.4	-0.6	0.1	0.4	-0.5	-0.6	-0.7
Comparative body size at age 10	0.8	2.2	8.2	-0.4	1.0	-2.9	-0.3	-1.1	1.6
Number of full brothers	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.0	-0.1	-0.4
Worry too long after embarrassment	0.5	0.8	2.8	0.8	0.7	0.4	0.6	0.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.3	-0.6	0.6	-0.5	-0.5	-0.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	0.3	0.5	0.9	0.2	0.2	-1.3
Number of children fathered	0.6	0.7	2.2	0.2	-0.1	1.5	0.5	1.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.5	-0.7	-0.0	-0.5	0.3	0.3
Age at first live birth	1.3	2.3	8.0	-1.2	-2.8	0.7	-1.4	-0.9	1.1
Pulse wave peak to peak time	2.3	2.8	5.5	-1.4	-1.0	-1.8	-1.2	-1.8	2.3
Health satisfaction	0.1	0.2	0.4	-0.3	-0.6	0.3	0.1	-0.3	-0.6
Shortness of breath walking on level ground	0.5	0.6	1.3	0.5	-0.3	1.1	0.8	-0.8	-0.9
Qualifications: College or University degree	1.0	3.2	5.9	-1.0	-2.1	-1.6	-0.5	-2.2	2.4
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.4	0.1	0.1	0.2	0.7	-0.8
Mouth/teeth dental problems: Loose teeth	1.6	2.0	3.9	-1.9	-2.0	1.5	-0.9	-0.5	-0.9
Emphysema/chronic bronchitis	0.3	0.4	1.2	0.2	-0.3	-0.5	0.4	-1.1	0.7
Medication for pain relief, constipation, heartburn	1.1	1.8	3.0	1.6	1.7	0.3	1.6	1.2	-1.0
Neck or shoulder pain in last month	0.4	0.5	1.0	-0.7	-1.0	-0.6	-0.8	-0.1	0.9
Medication: Blood pressure	0.6	1.1	2.4	0.7	0.2	0.8	1.0	1.6	-1.5
Angina (self-reported)	0.3	0.3	1.0	0.1	0.7	-0.6	1.0	0.1	-0.5
Migraine (self-reported)	2.5	3.1	10.0	-2.0	-3.2	1.2	-1.7	-0.3	0.5
Medication: Ibuprofen	3.5	4.1	6.1	-1.7	-1.9	-1.5	-2.5	-2.1	2.3
Medication: Allopurinol	0.2	0.2	0.9	0.2	0.3	-0.3	0.5	-0.2	0.9
Medication: Omeprazole	0.3	0.3	0.6	-0.8	-0.7	-0.3	-0.7	-0.4	0.4
Medication: Seretide 50 evohaler	0.4	0.4	1.0	0.4	-0.6	0.1	0.7	-0.7	1.0
Mean time to correctly identify matches	1.4	2.7	11.1	0.7	-0.1	3.3	1.4	1.2	-1.2
Heart disease (mother)	0.5	0.6	1.7	0.1	1.2	0.1	0.4	0.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	4.8	-1.9	-1.1	-0.8	-2.2	-0.3	0.5
Whole body fat mass	4.0	16.7	24.5	3.8	3.6	3.6	4.6	3.6	-5.0
Leg fat mass (right)	4.0	15.6	21.6	4.1	3.6	3.3	4.7	3.3	-4.5
Arm predicted mass (right)	0.1	0.5	1.8	0.9	0.5	0.2	1.3	-0.4	-0.2
Pulse rate, automated reading	4.0	12.8	22.3	3.0	4.1	2.9	3.4	2.9	-4.7
Alcohol intake frequency.	0.7	1.6	3.9	-0.1	0.6	1.6	0.0	1.7	-2.0
Comparative height size at age 10	0.5	2.8	6.0	2.3	1.6	0.1	2.5	1.2	-1.1
Number of full sisters	1.7	2.0	4.3	2.1	1.5	0.7	1.4	1.4	-1.1
Suffer from ‘nerves’	1.6	2.5	5.1	1.0	1.8	1.2	0.7	2.2	-1.9
Overall health rating	1.5	3.3	7.5	1.3	0.4	1.8	1.4	2.3	-2.7
Chest pain or discomfort	0.3	0.4	1.6	-0.0	0.7	-1.3	0.3	-0.5	0.3
Had major operations	0.5	0.6	2.2	-0.2	0.8	-1.5	-0.4	0.7	-0.0
Age at last live birth	2.2	3.3	9.7	-1.4	-3.1	0.7	-2.1	-0.7	1.6
Family relationship satisfaction	0.7	0.9	2.1	-0.5	-1.4	-0.6	-0.8	-1.0	1.1
Leg pain on walking	0.9	1.1	3.7	0.8	0.1	1.9	1.1	0.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.4	-0.3	0.1	0.1	-0.7	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	-0.1	-0.7	0.9	0.1	-0.4	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.8	-0.8	-1.1	1.7	0.1	-0.2	-0.3
Medication: Aspirin	0.1	0.1	0.5	-0.3	-0.1	0.1	0.1	0.0	-0.7
Supplements: Vitamin C	0.3	0.4	0.8	-0.5	-0.6	0.9	-0.4	-0.7	0.4
Knee pain experienced in last month	0.9	1.4	4.5	1.0	-0.9	2.1	1.3	0.6	0.6
Hypertension (Self-reported)	3.6	9.9	14.8	2.9	3.0	2.2	3.2	3.5	-3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.3	0.1	-0.3	-0.3	-0.5	-0.2
Illnesses of father: Heart disease	1.7	2.3	4.1	1.3	0.3	2.0	1.1	2.0	-1.7
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.4	0.2	-0.2	-0.7	-0.4	0.5
Smoking status: Previous	1.1	1.7	3.5	-1.9	-1.8	0.1	-1.6	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.9	0.3	-1.7	0.1	-0.6	-0.4	0.6
Whole body fat-free mass	0.1	0.7	1.7	0.7	0.1	-0.9	1.3	-1.0	0.5
Leg fat-free mass (right)	0.2	1.1	3.8	1.2	0.8	-0.8	1.9	-0.3	-0.5
Arm fat percentage (left)	4.6	18.5	28.7	4.0	4.2	3.2	4.8	3.9	-5.4
Average weekly red wine intake	0.2	0.3	1.7	-0.5	-1.3	0.0	-0.2	0.0	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-1.0	-0.3	-0.5	-1.0	0.1	-0.3
Mood swings	1.0	1.8	2.7	1.7	1.0	0.9	1.6	1.0	-1.6
Loneliness, isolation	0.5	0.7	2.2	-0.5	-1.5	0.9	-0.6	0.1	0.5
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.3	0.8	-0.0	-0.3	-0.3	-0.7
Ever had bowel cancer screening	0.5	0.6	1.5	-1.1	-0.3	1.2	-0.0	-0.8	0.0
Diabetes diagnosed by doctor	0.7	1.1	2.0	-0.9	-0.6	-1.1	-1.2	-1.4	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.7	-0.2	-1.3	-0.5	-1.1	-1.0	0.8
Friendships satisfaction	0.3	0.4	1.4	1.0	0.0	-1.2	0.3	0.2	0.0
Qualifications: nursing, teaching	0.8	1.2	3.2	0.1	0.6	-1.6	-0.5	-0.8	1.8
Commuting to job workplace: Walk	0.5	0.5	3.0	-0.3	0.1	-1.7	-0.1	-0.2	0.2
Eye problems/disorders: Cataract	0.3	0.4	1.3	0.3	0.2	-1.1	0.2	-0.4	0.9
Mouth/teeth dental problems: Mouth ulcers	2.9	4.7	5.9	2.4	2.3	2.1	2.3	2.0	-2.0
Medication for cholesterol	0.4	0.6	1.8	0.0	-1.3	-0.1	-0.6	-0.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	-0.1	-0.3	1.0	-0.4	0.4	-0.3
Back pain experienced in last month	1.6	2.4	4.6	-2.0	-2.1	-0.8	-2.0	-1.0	0.7
Mineral and other dietary supplements	0.7	1.0	2.2	-0.9	-1.4	-0.1	-1.5	-0.8	0.3
Breast cancer (self-reported)	4.5	5.4	8.0	2.2	2.1	1.5	2.8	2.3	-2.8
Asthma (self-reported)	0.3	0.5	1.7	1.3	-0.1	-0.8	0.8	-0.3	0.5
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.3	-0.2	-0.5	-0.4	0.4	-0.5
Osteoarthritis (self-reported)	1.4	1.8	3.0	1.6	1.1	0.7	1.6	1.7	-1.0
Medication: Aspirin	0.1	0.1	0.3	-0.1	0.1	0.1	0.4	0.2	-0.6
Medication: Gliclazide	2.7	3.0	6.0	-1.1	-1.4	-1.8	-0.9	-2.4	2.2
Illnesses of father: None of the above (group 1)	0.9	1.1	3.0	-0.9	-0.2	-1.3	-0.5	-1.7	0.8
Smoking status: Current	0.6	1.0	1.6	-0.4	-1.1	-0.6	-1.3	-1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.3	9.1	12.9	-3.6	-2.5	-2.4	-3.0	-3.5	3.0
Whole body water mass	0.1	0.7	1.5	0.7	0.1	-0.9	1.2	-1.0	0.5
Leg predicted mass (right)	0.2	1.2	4.0	1.2	0.9	-0.8	2.0	-0.2	-0.6
Arm fat mass (left)	3.7	15.1	21.9	3.9	3.8	2.8	4.7	3.2	-4.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.1	-0.2	0.4	0.4	0.6	-0.3
Average weekly champagne plus white wine intake	0.9	1.2	2.1	-0.7	-1.4	-1.1	-1.5	-0.5	1.2
Miserableness	0.6	1.1	2.9	1.0	1.1	-0.2	1.1	-0.1	-1.7
Guilty feelings	0.1	0.2	0.6	-0.8	0.3	-0.0	-0.5	-0.2	-0.6
Wears glasses or contact lenses	0.3	0.3	1.3	0.6	1.1	0.1	0.6	0.2	-0.1
Ever taken oral contraceptive pill	2.0	2.2	4.2	-1.0	-1.6	-1.0	-1.6	-1.4	2.1
Hearing aid user	0.3	0.3	1.2	-0.5	-0.2	0.3	-0.4	-1.1	0.6
Mother’s age at death	0.6	0.8	1.8	0.5	1.4	0.3	1.3	0.7	-0.6
Financial situation satisfaction	0.6	0.8	1.5	-0.4	-0.9	-1.2	-0.5	-0.4	1.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.1	0.8	-0.6	-0.3	-0.2	-0.3
Commuting to job workplace: Public transport	0.4	0.4	0.9	1.0	0.3	-0.8	0.9	-0.3	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.9	-0.2	-0.3	1.4	0.1	-0.0	-0.9
Medication: Blood pressure	4.8	9.2	18.3	1.8	2.7	2.7	2.7	3.4	-4.3
Pain type(s) experienced in last month: Hip pain	1.9	2.4	8.9	0.2	-0.4	3.0	0.6	1.2	-1.9
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.4	0.8	1.5	0.5	1.3	1.5	-0.9
High cholesterol (Self-reported)	2.6	4.6	8.8	-2.1	-0.9	-3.0	-2.2	-2.3	1.9
Medication: Bendroflumethiazide	6.6	10.1	20.7	2.3	2.2	2.6	2.7	3.9	-4.5
Medication: Paracetamol	0.1	0.1	0.3	0.5	-0.2	0.6	-0.2	0.5	0.1
Medication: Lisinopril	0.8	1.0	2.3	1.4	0.8	0.4	1.5	0.7	-0.8
Medication: Atorvastatin	3.1	3.9	6.7	-1.8	-1.4	-2.3	-2.1	-1.3	2.6
Illnesses of father: High blood pressure	1.2	1.5	4.9	1.4	0.8	0.8	0.7	2.2	-0.7
Alcohol drinker status: Never	0.5	0.6	1.6	-0.4	-1.1	1.3	-0.1	-0.1	-0.7
Ever smoked	2.1	3.6	6.2	-2.1	-2.4	-0.4	-2.5	-1.8	1.4
Basal metabolic rate	0.2	0.9	3.2	1.2	0.7	-0.3	1.8	-0.3	-0.4
Leg fat percentage (left)	5.0	17.9	24.8	3.9	3.6	4.4	4.5	3.8	-5.0
Arm fat-free mass (left)	0.1	0.8	2.6	1.1	0.7	0.3	1.6	-0.4	-0.2
Number of operations (self-reported)	0.6	0.9	3.1	-0.4	0.5	-1.8	-0.9	-1.0	0.6
Average weekly beer plus cider intake	1.5	2.2	5.2	1.6	2.3	-0.3	1.6	1.1	-1.3
Irritability	0.3	0.5	1.4	0.8	0.5	-0.6	1.2	-0.5	-0.1
Risk taking	1.7	2.4	3.4	-1.8	-1.0	-1.5	-1.8	-1.1	1.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.0	-0.9	-1.4	0.4	-0.5	-0.4	0.3
Fractured/broken bones in last 5 years	0.5	0.6	2.0	0.7	0.8	-0.6	0.4	1.4	-0.4
Age started oral contraceptive pill	3.5	4.4	7.4	1.5	0.9	2.7	2.4	2.4	-2.1
Diastolic blood pressure, automated reading	8.0	24.8	30.7	5.4	4.5	4.2	5.5	4.9	-5.2
Ever depressed for a whole week	1.9	2.4	6.1	-1.1	-0.5	-2.0	-1.2	-2.5	1.0
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.1	0.9	-0.8	-0.6	0.0	-0.5
Commuting to job workplace: Cycle	2.0	2.4	9.7	-1.1	-0.5	-3.1	-0.6	-1.2	1.1
Myopia	0.5	0.7	2.4	-1.6	-0.7	-0.7	-0.8	-0.3	0.0
Vascular/heart problems diagnosed by doctor	2.4	6.6	11.1	-2.1	-2.1	-1.6	-2.5	-3.3	3.3
Cholesterol lowering medication	0.4	0.6	1.5	-1.2	-0.3	-0.4	-1.0	-0.9	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.7	-1.0	-0.3	-0.5	-0.5	0.4
Pain experienced in last month	0.3	0.5	2.5	0.0	1.6	-0.4	0.1	-0.1	0.0
Supplements: Calcium	0.8	0.9	1.6	-0.7	-1.0	-1.1	-0.7	-0.7	1.3
Basal cell carcinoma (self-reported)	3.7	4.4	7.1	-2.2	-2.7	-0.6	-2.5	-1.7	2.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.4	0.8	-0.4	0.5	0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	1.0	0.2	0.7	0.6	0.7	0.1
Heart disease (siblings)	1.1	1.4	3.6	-0.0	0.7	1.0	0.1	1.9	-1.8
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.0	-0.2	0.1	0.5	0.8	-0.7
Pack years of smoking	6.8	10.0	19.8	3.3	4.4	0.5	4.0	2.6	-2.4
Impedance of whole body	0.5	2.6	5.0	-0.2	-1.3	2.1	-1.2	2.2	-1.6
Leg fat mass (left)	4.3	16.8	23.0	4.1	3.7	3.7	4.8	3.4	-4.7
Arm predicted mass (left)	0.1	0.6	2.1	1.0	0.6	0.0	1.4	-0.5	-0.1