Hub : Genes

AC074117.10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0630 0.0340 8.0e-04 0.038 NA 0.013 NA 0.023 4.1e-04 NA 2.7e-02 NA 4.8e-03
2 GTEx Adipose Visceral Omentum 0.1390 0.0660 1.1e-04 0.093 NA 0.044 NA 0.082 1.5e-05 NA 2.3e-03 NA 5.0e-05
3 GTEx Artery Aorta 0.0630 0.0350 3.1e-03 0.036 NA 0.030 NA 0.032 4.6e-03 NA 8.9e-03 NA 6.8e-03
4 GTEx Artery Coronary 0.1310 0.0680 1.2e-03 0.170 NA 0.125 NA 0.124 2.4e-06 NA 5.4e-05 NA 6.0e-05
5 GTEx Artery Tibial 0.1290 0.0443 3.1e-08 0.138 NA 0.098 NA 0.134 6.0e-11 NA 4.0e-08 NA 1.1e-10
6 GTEx Brain Cerebellum 0.1260 0.0620 2.6e-03 0.085 NA 0.069 NA 0.064 1.7e-03 NA 4.4e-03 NA 6.0e-03
7 GTEx Breast Mammary Tissue (Male) 0.0799 0.0495 2.3e-02 0.128 NA 0.055 NA 0.002 7.0e-04 NA 2.1e-02 NA 2.8e-01
8 GTEx Breast Mammary Tissue (Female) 0.0582 0.0459 9.1e-02 0.013 NA -0.010 NA 0.038 1.3e-01 NA 9.9e-01 NA 2.7e-02
9 GTEx Cells Transformed fibroblasts 0.2070 0.0650 2.7e-10 0.194 NA 0.180 NA 0.061 1.6e-14 NA 1.6e-13 NA 2.3e-05
10 GTEx Colon Sigmoid 0.1320 0.0490 2.8e-05 0.179 NA 0.112 NA 0.141 6.5e-07 NA 9.4e-05 NA 1.1e-05
11 GTEx Colon Transverse 0.1280 0.0520 1.5e-05 0.132 NA 0.144 NA 0.138 7.7e-07 NA 2.3e-07 NA 4.2e-07
12 GTEx Esophagus Gastroesophageal Junction 0.1240 0.0620 2.3e-03 0.126 NA 0.086 NA 0.080 2.6e-05 NA 4.9e-04 NA 7.6e-04
13 GTEx Esophagus Mucosa 0.1190 0.0440 3.9e-08 0.143 NA 0.128 NA 0.137 8.7e-10 NA 6.6e-09 NA 2.1e-09
14 GTEx Esophagus Muscularis 0.1720 0.0790 3.0e-05 0.145 NA 0.086 NA 0.061 4.0e-09 NA 6.6e-06 NA 1.5e-04
15 GTEx Lung 0.0748 0.0287 1.7e-06 0.059 NA 0.046 NA 0.053 2.5e-05 NA 1.9e-04 NA 6.6e-05
16 GTEx Nerve Tibial 0.0425 0.0228 4.2e-03 0.047 NA 0.019 NA 0.040 2.9e-04 NA 1.6e-02 NA 7.7e-04
17 GTEx Ovary 0.1630 0.0700 6.3e-04 0.042 NA 0.053 NA 0.028 3.4e-02 NA 2.0e-02 NA 6.9e-02
18 GTEx Pituitary 0.2270 0.0830 1.4e-05 0.234 NA 0.242 NA 0.289 1.4e-06 NA 9.0e-07 NA 5.6e-08
19 GTEx Prostate 0.1360 0.0660 2.3e-03 0.012 NA 0.001 NA 0.023 1.6e-01 NA 3.1e-01 NA 8.8e-02
20 GTEx Stomach 0.0650 0.0370 6.3e-03 0.012 NA 0.003 NA 0.013 8.7e-02 NA 2.3e-01 NA 7.8e-02
21 GTEx Testis 0.1370 0.0520 3.2e-05 0.075 NA 0.114 NA 0.123 3.1e-04 NA 9.4e-06 NA 4.5e-06
22 GTEx Thyroid 0.1680 0.0570 5.3e-10 0.135 NA 0.144 NA 0.146 1.7e-10 NA 3.7e-11 NA 2.7e-11
23 GTEx Vagina 0.1390 0.0670 3.3e-03 0.043 NA 0.065 NA 0.048 3.8e-02 NA 1.4e-02 NA 3.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bipolar Disorder (2018) 2.6 4.1 10.9 1.8 1.8 1.6 0.1 1.7 -1.8 0.0 -3.3 1.6 1.7 1.0 1.4 2.0 2.1 2.1 0.8 2.9 3.0 1.5 -3.0 2.8 1.8 2.7
Bipolar Disorder or Schizophrenia 1.3 3.2 24.6 -0.6 -1.1 -1.2 -2.4 -1.2 1.1 0.0 -4.7 -1.1 -1.1 -1.4 -1.6 -0.6 -0.4 -0.8 -2.2 0.4 0.7 -1.3 -5.0 0.4 -1.0 -0.1
Depressed Affect (Nagel 2018) 1.1 2.3 4.9 1.8 1.5 1.5 1.2 1.9 -1.4 0.0 0.6 1.8 1.5 0.9 0.9 2.0 2.0 1.4 1.2 1.8 1.9 2.2 0.3 1.8 1.4 1.9
Depression (Nagel 2018) 1.3 1.9 4.5 1.5 1.0 1.0 1.4 1.4 -1.1 0.0 -1.8 1.0 1.0 0.6 1.4 1.8 1.3 0.8 1.1 2.1 1.5 1.7 -1.4 2.0 0.9 2.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 4.6 -0.6 -0.5 -0.4 0.3 -0.4 0.7 0.0 2.2 0.5 -0.4 0.1 0.5 -0.2 -0.6 -0.5 -0.8 -1.7 -1.5 -0.4 0.9 -0.9 -0.5 -1.0
Neuroticism (Nagel 2018) 0.3 0.6 4.1 1.0 0.5 0.6 -0.1 0.9 -0.3 0.0 2.0 0.8 0.5 0.1 -0.4 0.9 0.9 -0.0 0.6 0.4 0.1 1.2 1.4 0.2 0.3 0.5
Schizophrenia (2018) 3.5 7.2 15.7 -2.2 -2.8 -2.9 -3.2 -2.9 2.9 0.0 -3.4 -2.6 -2.8 -2.6 -3.1 -2.3 -2.2 -2.7 -3.5 -1.9 -1.6 -2.9 -4.0 -1.7 -2.7 -2.3
Schizophrenia vs Biploar Disorder 7.7 10.2 15.8 -3.4 -3.3 -3.2 -2.6 -3.5 3.4 0.0 -0.4 -3.4 -3.3 -2.6 -4.0 -3.8 -3.6 -3.5 -2.3 -3.8 -3.6 -3.5 0.7 -4.0 -3.3 -3.7
Worry (Nagel 2018) 0.2 0.5 2.8 1.1 0.4 0.5 -0.1 0.8 -0.3 0.0 1.7 0.9 0.4 0.4 -0.2 0.8 0.9 -0.0 0.7 0.5 0.1 1.0 1.1 0.3 0.3 0.4
Alzheimer’s Disease (in mother) 0.9 1.1 2.1 1.2 1.1 1.2 1.0 1.2 -0.7 0.0 0.3 1.2 1.2 1.2 1.1 0.8 1.3 1.1 0.8 0.7 1.5 1.2 -1.0 1.0 1.1 0.6
Alzheimer’s Disease (in father) 0.1 0.1 0.7 -0.4 -0.3 -0.4 -0.2 -0.4 0.1 0.0 -0.2 -0.5 -0.3 -0.2 -0.8 -0.6 -0.5 -0.1 -0.3 0.1 0.2 -0.2 0.4 -0.3 -0.2 -0.3
Alzheimer’s Disease (including proxy) 0.1 0.2 1.1 0.1 0.5 0.8 0.3 0.5 0.2 0.0 -0.2 0.1 0.6 0.5 -0.1 -0.2 0.2 0.0 -0.0 0.0 0.6 0.2 -1.0 0.2 0.4 -0.3
Crohns Disease (2017) 6.6 14.5 33.9 4.3 4.1 4.1 2.2 4.0 -4.0 0.0 -2.4 3.6 4.1 3.3 4.3 5.0 4.1 3.6 3.2 4.8 3.4 2.9 -2.4 5.8 3.9 4.3
Irritable Bowel Disease (IBD) 6.1 14.6 27.7 4.2 4.3 4.4 2.6 4.3 -4.1 0.0 -0.8 3.7 4.3 3.5 3.7 4.7 4.1 3.9 3.8 4.7 3.7 3.4 -0.4 5.3 4.2 4.5
Ulcerative Colitis (UC) 3.0 5.5 8.2 2.3 2.7 2.8 1.9 2.7 -2.5 0.0 0.5 2.2 2.8 2.1 1.8 2.5 2.5 2.6 2.5 2.8 2.6 2.4 1.2 2.7 2.7 2.9
Major Depression (MDD) 3.2 3.9 10.0 -1.7 -2.1 -2.2 -2.1 -2.0 2.1 0.0 -3.2 -2.1 -2.1 -2.0 -2.5 -1.8 -1.6 -1.8 -2.0 -1.3 -1.0 -1.9 -2.8 -1.6 -2.0 -1.5
Reaction Time 0.8 1.5 4.8 1.6 1.5 1.5 0.1 1.2 -1.5 0.0 -0.2 0.5 1.5 1.9 2.2 1.2 1.4 1.2 1.2 1.0 0.7 0.3 0.5 1.4 1.5 0.9
Verbal and Numeric Reasoning (VNR) 0.9 2.1 6.5 -1.7 -1.1 -0.9 -0.5 -1.1 1.7 0.0 1.7 -0.9 -1.1 -1.1 -1.0 -1.3 -1.6 -1.4 -1.3 -2.5 -2.4 -1.4 0.9 -1.9 -1.3 -1.7
Breast Cancer 0.2 0.4 3.8 0.3 0.0 -0.1 0.7 0.1 0.1 0.0 -0.8 0.5 0.0 0.2 0.9 0.4 0.4 0.4 -0.7 0.4 0.4 0.3 -2.0 0.8 0.2 0.1
Ovarian Cancer 2.8 3.7 5.8 2.0 2.0 2.0 1.4 2.1 -1.9 0.0 2.4 2.4 2.0 1.9 2.2 2.1 2.2 2.0 1.8 1.4 1.4 2.0 2.2 1.5 2.0 1.4
Prostate Cancer 0.7 1.0 8.7 -0.4 -0.8 -0.7 -0.8 -0.5 0.7 0.0 -2.4 -0.1 -0.8 -1.7 -0.2 -0.3 -0.3 -0.9 -0.8 0.4 -0.2 -0.1 -3.0 0.4 -0.9 -0.2
Age at First Birth 0.6 0.8 5.9 0.7 0.7 0.8 0.6 0.7 -0.8 0.0 -2.4 0.3 0.8 1.0 0.7 0.9 0.5 0.7 0.5 1.0 0.5 0.2 -1.4 1.0 0.7 1.0
Bipolar Disorder (2011) 4.1 3.9 7.7 2.2 2.0 1.9 0.1 1.9 -2.0 0.0 -2.2 1.8 1.9 1.4 0.9 2.5 2.5 2.1 1.3 2.6 2.7 1.5 -1.9 2.8 2.0 2.4
Body Mass Index (BMI) (2010) 1.4 1.9 3.3 -1.7 -1.3 -1.3 -0.6 -1.4 1.4 0.0 -0.9 -1.6 -1.3 -1.4 -1.5 -1.5 -1.8 -1.5 -1.5 -1.4 -1.4 -1.5 -0.1 -1.7 -1.4 -1.6
Coronary Artery Disease (CAD) 0.7 0.9 4.5 0.7 1.0 1.1 0.5 0.8 -1.0 0.0 -2.1 0.1 1.1 0.9 0.9 1.2 0.6 0.6 0.4 0.9 0.6 0.1 -1.0 1.1 0.9 1.2
Crohns Disease (2012) 2.2 3.6 10.0 1.9 1.9 1.9 1.6 1.9 -1.9 0.0 -1.6 1.3 1.9 1.2 2.6 2.8 1.8 1.8 1.5 2.2 1.5 1.2 -1.8 3.2 1.8 2.4
Mean Putamen Volume 0.2 0.3 2.6 0.1 0.1 0.1 0.0 0.1 0.1 0.0 -1.3 0.0 0.1 -0.0 0.5 0.5 0.2 -0.0 -0.7 0.2 -0.0 -0.4 -1.6 0.4 0.1 0.0
Fasting Glucose 28.5 34.1 56.1 -5.8 -5.7 -5.4 -5.2 -6.2 6.0 0.0 4.3 -6.2 -5.7 -4.6 -7.1 -6.7 -6.7 -6.5 -3.9 -7.4 -7.5 -5.9 5.5 -6.0 -6.1 -5.5
HbA1C 0.3 0.3 1.0 -0.7 -0.4 -0.4 0.6 -0.3 0.4 0.0 1.0 -0.7 -0.3 -0.6 -0.5 0.0 -0.4 -0.2 -0.2 -0.9 -0.9 -0.3 1.0 -1.0 -0.3 -0.0
HDL Cholesterol 1.0 1.6 3.2 -1.3 -1.4 -1.6 -0.3 -1.3 1.3 0.0 0.4 -1.6 -1.4 -1.1 -1.0 -1.1 -1.5 -1.0 -1.7 -1.6 -1.2 -1.1 0.6 -1.8 -1.3 -1.5
LDL Cholesterol 1.2 1.9 13.5 1.5 0.5 0.5 0.2 0.7 -0.5 0.0 -1.8 1.8 0.5 0.9 2.1 1.6 1.4 0.7 0.4 1.5 0.9 0.8 -3.7 2.1 0.5 1.4
Lupus 3.6 5.4 8.8 2.5 2.5 2.4 2.1 2.4 -2.8 0.0 0.3 2.2 2.5 2.2 1.9 2.4 2.5 2.4 2.8 3.0 2.6 2.5 0.8 2.7 2.5 2.8
Neuroticism (2016) 0.1 0.2 0.7 -0.1 -0.3 -0.3 0.6 0.1 0.4 0.0 0.8 0.4 -0.4 -0.5 -0.2 0.3 -0.2 -0.4 -0.5 -0.5 -0.0 0.5 -0.5 -0.4 -0.4 0.1
Primary Biliary Cirrhosis 4.0 5.6 10.8 2.5 2.4 2.5 1.3 2.4 -2.5 0.0 -0.8 2.4 2.5 1.7 2.1 2.2 2.8 2.5 2.8 3.3 3.3 2.2 -0.8 3.0 2.5 3.1
Rheumatoid Arthritis 0.3 0.3 1.3 -0.5 -0.4 -0.3 0.1 -0.4 0.5 0.0 -0.4 -1.0 -0.4 -0.1 0.0 -0.6 -0.8 -0.7 -0.5 -0.8 -1.1 -0.8 0.3 -0.6 -0.5 -0.8
Schizophrenia (2014) 3.1 6.9 19.1 -2.2 -2.7 -2.8 -2.8 -2.8 2.6 0.0 -4.3 -2.6 -2.7 -2.6 -2.7 -2.2 -2.2 -2.3 -3.3 -1.6 -1.2 -2.8 -4.4 -1.5 -2.5 -2.1
Triglycerides 117.3 192.2 392.0 15.2 13.0 13.0 9.2 13.9 -12.9 0.0 -9.3 15.2 13.1 11.3 16.0 17.5 15.2 13.3 10.3 17.4 15.1 13.1 -12.9 19.8 13.2 16.7
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.8 -1.3 -0.5 -0.5 -0.8 -0.9 0.8 0.0 -0.3 -1.4 -0.6 -0.7 -1.2 -1.7 -1.2 -0.7 0.1 -1.1 -0.5 -1.2 1.2 -1.6 -0.4 -0.7
Ulcerative Colitis 5.4 7.8 12.8 2.7 3.0 3.1 2.4 3.0 -2.9 0.0 0.2 3.0 3.1 2.3 1.9 2.8 2.9 2.9 3.5 3.6 3.3 2.9 0.8 3.3 3.0 3.6
Blood Eosinophil Count 1.0 7.8 34.5 2.4 2.6 2.5 1.5 2.7 -2.7 0.0 5.9 2.5 2.6 3.1 2.6 2.1 2.5 2.9 2.4 0.9 2.1 2.6 5.8 0.5 2.7 1.6
Blood Platelet Count 15.9 184.9 368.6 14.2 13.2 12.7 12.0 13.9 -13.6 0.0 -7.3 13.5 13.2 10.8 14.3 17.1 14.2 14.1 11.4 17.4 14.9 13.6 -9.4 19.2 13.5 17.0
Blood Red Count 0.9 8.8 84.8 0.2 1.1 0.9 0.1 0.9 -1.0 0.0 9.2 1.4 1.1 2.0 -0.4 -1.4 0.4 1.3 2.0 -1.0 0.9 2.2 9.1 -2.8 1.2 -0.3
Blood White Count 14.8 109.5 196.0 11.5 10.6 10.4 7.4 11.1 -10.7 0.0 -2.9 11.8 10.6 9.8 11.2 12.6 11.4 10.9 9.1 12.9 11.6 10.7 -5.3 14.0 10.7 12.2
Heel T-Score 0.4 3.2 5.9 -2.2 -1.5 -1.4 -1.3 -1.7 1.8 0.0 -1.8 -2.4 -1.4 -2.2 -2.3 -2.4 -1.7 -1.6 -1.6 -1.9 -1.3 -2.3 0.2 -2.3 -1.5 -1.9
BMI 0.7 4.3 26.9 -1.8 -1.1 -1.2 -1.7 -1.5 0.9 0.0 4.2 -1.6 -1.2 -0.7 -1.8 -3.1 -1.7 -1.0 -0.5 -2.1 -0.8 -1.0 5.2 -3.1 -1.1 -2.1
Height 3.6 69.7 130.0 -9.5 -8.5 -8.5 -5.9 -9.0 8.3 0.0 2.0 -9.6 -8.6 -7.5 -9.1 -10.3 -9.7 -8.4 -7.0 -10.2 -8.5 -8.3 4.0 -11.4 -8.5 -9.7
Waist Hip Ratio (WHR) 0.5 2.4 19.9 -0.5 -1.8 -2.0 -1.4 -1.6 1.5 0.0 -1.7 0.6 -1.9 -1.9 -1.9 -0.8 -0.4 -1.1 -0.6 -0.2 -0.0 -0.3 -4.5 -0.2 -1.6 -0.7
Systolic Blood Pressure 3.6 18.1 28.2 3.4 4.6 4.7 5.1 4.7 -4.2 0.0 1.6 5.2 4.7 3.1 3.4 3.7 3.7 4.5 5.2 4.9 5.2 5.2 0.5 4.5 4.6 5.3
Smoking Status 0.3 0.7 7.4 0.2 0.3 0.5 -0.2 0.2 -0.4 0.0 -2.7 -0.3 0.3 -0.0 0.2 0.1 0.1 0.1 0.5 0.9 0.6 -0.3 -2.2 1.0 0.3 0.5
Allergy or Eczema 5.7 15.0 22.7 4.2 4.2 4.3 3.5 4.3 -4.2 0.0 -0.3 3.6 4.2 3.8 4.8 4.3 4.1 3.9 4.2 4.6 3.8 3.9 0.6 4.7 4.1 4.0
Cardiovascular Disease 7.1 23.4 46.4 5.1 4.7 4.7 3.5 4.9 -5.0 0.0 -0.6 5.7 4.7 3.6 4.2 5.5 5.0 4.7 5.6 6.7 5.5 5.5 -1.4 6.8 4.7 6.2
Hypothyroidism (self reported) 0.2 0.5 2.2 0.5 0.5 0.5 0.6 0.4 -0.6 0.0 0.7 1.2 0.4 0.8 0.4 0.3 0.4 0.5 1.5 0.9 0.6 0.8 0.5 0.7 0.5 1.0
Respiratory disease 0.1 0.2 0.9 0.6 0.1 0.1 -0.9 0.1 -0.1 0.0 -0.9 0.1 0.2 0.3 0.3 -0.0 0.6 0.2 0.4 0.7 0.7 0.1 -0.6 0.4 0.1 0.4
Type 2 Diabetes (T2D) (2018) 13.4 25.1 46.2 -5.8 -5.2 -5.2 -3.6 -5.4 4.8 0.0 2.1 -5.9 -5.2 -5.1 -5.7 -6.2 -5.7 -5.1 -4.0 -5.8 -4.9 -4.6 2.7 -6.8 -5.1 -5.3
Lung FEV1/FVC ratio 0.1 0.5 4.4 0.2 -0.3 -0.3 -0.4 -0.1 0.2 0.0 2.1 1.5 -0.4 -0.1 1.1 0.6 0.1 -0.5 -0.5 -0.5 -0.9 0.5 -0.1 0.3 -0.3 -0.6
Lung FVC 0.6 2.9 7.2 1.5 1.4 1.4 1.4 1.4 -1.5 0.0 -2.5 1.8 1.4 1.2 1.1 1.9 1.5 1.7 1.1 2.3 1.9 1.1 -2.7 2.6 1.5 1.9
Neuroticism 2.4 5.7 9.9 2.8 2.6 2.7 2.0 3.0 -2.4 0.0 2.1 2.5 2.6 2.5 1.8 2.7 2.7 2.2 2.5 2.1 2.0 3.1 2.0 2.0 2.5 2.5
Chronotype (morning person) 0.2 0.5 5.4 0.4 -0.3 -0.3 -1.1 -0.0 0.2 0.0 2.3 1.2 -0.3 0.7 0.5 0.2 0.2 -0.2 -0.8 -0.7 -0.6 0.6 0.4 -0.5 -0.3 -0.5
Hair Pigment 2.0 56.0 83.4 8.4 7.8 7.8 5.8 8.5 -8.1 0.0 3.6 9.1 7.8 7.1 7.4 8.6 8.7 7.7 7.8 8.1 7.5 8.6 3.2 8.1 7.8 7.9
Tanning 1.6 19.3 40.6 -5.1 -4.1 -4.1 -2.1 -4.5 4.3 0.0 1.9 -5.1 -4.1 -3.4 -4.8 -5.5 -5.2 -4.0 -4.6 -5.6 -4.1 -4.7 3.1 -6.4 -4.1 -5.2
Hand grip strength (left) 2.2 5.8 9.4 -2.4 -2.6 -2.4 -2.8 -2.7 2.6 0.0 0.5 -2.0 -2.5 -2.0 -2.7 -2.6 -2.5 -2.6 -2.1 -3.0 -2.6 -2.6 1.0 -3.1 -2.6 -2.8
Number of treatments/medications taken 7.9 14.1 23.8 3.6 3.9 3.9 4.1 4.2 -4.0 0.0 0.8 4.0 3.9 2.5 3.0 4.3 3.8 3.9 4.2 4.5 4.2 4.6 0.2 4.4 3.9 4.9
Average weekly spirits intake 0.3 0.4 3.2 0.0 0.3 0.3 0.8 0.5 -0.1 0.0 -1.4 0.0 0.4 -0.3 0.3 0.8 0.3 0.5 0.1 0.5 0.4 0.3 -1.8 0.7 0.3 1.1
Sensitivity / hurt feelings 0.3 0.5 3.3 0.5 0.4 0.4 0.4 0.7 -0.6 0.0 1.8 0.4 0.5 -0.0 -0.0 0.6 0.5 0.4 1.0 0.5 0.3 1.1 1.3 0.1 0.4 1.1
Frequency of depressed mood in last 2 weeks 1.6 2.2 4.5 1.9 1.3 1.3 0.9 1.5 -1.5 0.0 -0.7 1.8 1.3 1.2 1.4 2.0 1.7 1.2 1.6 2.0 1.3 1.8 -0.6 2.1 1.3 1.8
Hearing difficulty/problems: Yes 1.0 1.5 3.1 1.5 1.3 1.2 -0.1 1.2 -1.1 0.0 -0.3 1.6 1.3 1.5 -0.5 0.6 1.6 1.5 1.8 1.7 1.7 1.3 0.5 1.3 1.4 1.2
Relative age of first facial hair 3.0 6.2 14.0 2.9 2.1 2.2 1.0 2.3 -1.9 0.0 -3.5 2.1 2.2 1.9 3.3 3.3 2.9 2.1 0.3 3.0 2.5 1.6 -3.7 3.7 2.1 2.1
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 5.2 1.7 1.5 1.6 0.7 1.7 -1.4 0.0 -1.1 1.4 1.6 1.2 1.4 1.4 1.9 1.7 1.4 1.9 2.3 1.7 -1.6 1.6 1.5 1.8
Ever used hormone-replacement therapy (HRT) 8.0 10.2 15.5 -3.5 -3.7 -3.8 -2.1 -3.5 3.8 0.0 -1.3 -2.9 -3.7 -3.9 -3.9 -3.4 -3.3 -3.4 -3.4 -3.2 -2.4 -2.7 -2.3 -3.4 -3.6 -3.2
Ever had hysterectomy (womb removed) 0.8 0.9 5.5 0.4 0.5 0.5 0.7 0.5 -0.5 0.0 -1.7 0.6 0.6 0.2 0.4 0.4 0.6 0.7 0.7 1.3 1.3 0.6 -2.4 1.2 0.6 1.1
Systolic blood pressure, automated reading 2.7 8.0 16.8 2.2 3.1 3.1 4.1 3.1 -2.7 0.0 1.6 3.4 3.1 2.4 1.8 2.2 2.3 3.2 3.5 2.8 3.6 3.4 1.0 2.5 3.1 3.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 4.4 -0.7 -0.4 -0.4 -0.4 -0.4 0.4 0.0 2.1 -0.6 -0.4 -0.3 -0.8 -1.1 -0.6 -0.5 0.3 -1.0 -0.4 -0.3 2.1 -1.5 -0.4 -0.4
Angina 2.2 2.8 6.3 2.2 1.6 1.7 0.5 1.9 -1.5 0.0 0.8 2.2 1.6 1.0 0.5 2.1 2.5 1.3 1.5 2.2 2.0 2.2 -1.1 2.3 1.4 1.7
Medication for hormone replacement therapy 0.5 0.6 2.5 -0.8 -0.6 -0.9 1.1 -0.6 0.6 0.0 -1.1 0.1 -0.7 -1.2 -1.2 -0.3 -0.7 0.0 -0.5 0.3 0.8 0.1 -1.6 0.2 -0.5 0.4
Vitamin and mineral supplements 4.6 6.2 10.6 -2.4 -2.6 -2.4 -3.3 -2.7 2.6 0.0 0.1 -2.4 -2.5 -1.9 -2.0 -2.6 -2.2 -2.8 -2.8 -3.1 -2.9 -3.0 0.0 -3.0 -2.6 -3.2
Supplements: Zinc 0.2 0.2 1.0 -0.8 0.1 0.1 1.0 -0.1 0.2 0.0 -0.2 -0.2 0.1 0.0 -0.4 -0.8 -0.9 -0.0 0.3 -0.3 0.2 -0.2 0.3 -0.4 0.0 -0.2
Medication: Co-codamol 0.3 0.4 3.9 0.2 -0.2 -0.4 0.2 -0.0 -0.2 0.0 -1.4 0.1 -0.3 -0.4 0.7 0.7 0.0 0.3 0.2 0.3 0.1 0.2 -2.0 0.9 -0.1 0.1
Medication: Metformin 8.0 11.3 20.7 -3.9 -3.4 -3.5 -2.1 -3.5 3.2 0.0 1.5 -4.0 -3.4 -3.7 -3.7 -3.9 -3.7 -3.4 -3.3 -4.1 -3.2 -3.3 1.9 -4.5 -3.4 -3.6
Diabetes (father) 4.8 5.9 12.6 -2.8 -2.2 -2.2 -1.3 -2.4 2.3 0.0 1.6 -2.7 -2.2 -1.6 -2.0 -3.0 -3.0 -2.2 -2.1 -3.5 -2.6 -2.6 2.2 -3.6 -2.2 -2.9
Diabetes (mother) 2.1 2.7 9.5 -1.4 -1.0 -0.8 -0.6 -1.1 1.2 0.0 2.5 -1.7 -0.9 -0.7 -1.0 -1.9 -1.4 -1.4 -0.9 -2.4 -2.0 -1.5 3.1 -2.9 -1.2 -2.2
Severe depression (siblings) 0.1 0.1 0.5 -0.2 -0.0 -0.2 0.2 -0.2 -0.0 0.0 -0.2 -0.7 -0.1 -0.0 0.4 -0.1 -0.2 0.4 -0.1 -0.3 0.2 -0.2 0.7 -0.3 0.0 0.0
Pack years adult smoking proportion 0.0 0.1 0.5 0.1 -0.3 -0.4 -0.1 -0.1 -0.1 0.0 0.3 0.1 -0.3 0.2 0.3 -0.1 -0.3 0.0 0.0 0.4 0.7 0.5 0.1 0.1 -0.1 0.2
Impedance of leg (right) 2.0 9.5 88.7 1.8 0.6 0.7 1.0 1.1 -0.4 0.0 -8.1 1.6 0.6 0.1 1.8 3.2 1.7 0.5 -0.2 3.2 1.3 0.8 -9.4 4.3 0.5 2.7
Leg fat-free mass (left) 4.9 25.7 58.7 -5.3 -4.4 -4.5 -3.7 -4.9 4.0 0.0 6.5 -4.9 -4.4 -3.5 -5.2 -6.7 -5.3 -4.0 -3.1 -6.5 -4.2 -3.9 7.6 -7.7 -4.2 -5.9
Trunk fat percentage 0.1 0.5 3.2 -0.7 -0.6 -0.8 0.4 -0.7 0.6 0.0 -1.2 -0.3 -0.6 -1.4 -0.9 -0.6 -0.5 -0.2 -0.3 -0.1 0.5 -0.3 -1.8 0.1 -0.5 -0.1
Hand grip strength (right) 2.1 5.8 10.4 -2.6 -2.5 -2.4 -2.2 -2.6 2.5 0.0 1.3 -2.1 -2.5 -2.1 -2.6 -2.8 -2.7 -2.4 -2.1 -3.1 -2.4 -2.3 1.3 -3.2 -2.5 -2.9
Townsend deprivation index at recruitment 1.5 2.1 7.0 -0.9 -1.8 -1.8 -2.6 -1.7 1.4 0.0 -0.9 -1.4 -1.8 -1.1 -1.0 -1.3 -1.1 -1.6 -1.7 -1.4 -1.2 -1.5 -0.9 -1.3 -1.7 -1.7
Current tobacco smoking 0.5 0.8 1.9 1.4 0.6 0.6 -0.6 0.7 -0.8 0.0 -0.5 1.3 0.6 0.9 0.9 1.1 1.2 0.7 0.6 1.0 0.9 0.8 -1.0 1.3 0.7 0.7
Average weekly fortified wine intake 0.3 0.3 0.6 -0.5 -0.6 -0.7 -0.5 -0.6 0.7 0.0 0.1 -0.8 -0.6 -0.1 -0.5 -0.7 -0.6 -0.6 -0.6 -0.6 -0.5 -0.4 0.1 -0.7 -0.6 -0.6
Maternal smoking around birth 0.3 0.4 2.0 -0.6 -0.5 -0.5 -1.0 -0.7 0.3 0.0 -1.4 -0.6 -0.5 -0.6 -1.2 -0.8 -0.4 -0.1 -0.2 0.4 0.7 -0.8 -0.8 -0.1 -0.3 0.1
Fed-up feelings 1.2 2.1 4.0 1.9 1.3 1.3 -0.2 1.5 -1.3 0.0 1.9 1.9 1.3 1.3 1.1 1.9 2.0 1.3 1.2 1.2 1.3 1.9 1.6 1.2 1.3 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.4 0.8 0.5 0.6 1.0 0.8 -0.7 0.0 -0.8 0.6 0.5 0.3 0.8 1.1 0.7 0.5 0.6 1.2 0.8 0.9 -0.1 1.0 0.5 1.1
Relative age voice broke 2.8 4.3 8.4 2.4 2.3 2.4 1.3 2.4 -2.2 0.0 -1.2 2.0 2.4 1.9 2.5 2.7 2.6 2.0 1.1 2.4 2.2 1.5 -0.6 2.9 2.3 1.7
Taking other prescription medications 3.0 4.6 8.7 2.1 2.5 2.5 1.6 2.4 -2.4 0.0 0.1 1.6 2.5 1.8 2.0 2.1 2.5 2.3 2.4 2.5 3.0 2.2 0.7 2.0 2.4 2.7
Age when periods started (menarche) 2.7 6.5 21.9 -1.6 -3.1 -3.1 -2.8 -2.6 2.6 0.0 -2.8 -1.4 -3.1 -2.9 -1.8 -1.4 -1.7 -2.7 -3.8 -1.6 -2.1 -1.8 -4.7 -1.2 -3.0 -2.5
Bilateral oophorectomy (both ovaries removed) 4.1 4.7 8.1 2.0 2.2 2.1 2.1 2.4 -2.3 0.0 0.7 2.3 2.2 1.8 1.5 2.0 2.1 2.4 2.7 2.7 2.8 2.8 0.8 2.2 2.3 2.8
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 5.2 -2.1 -1.4 -1.3 -1.3 -1.7 1.5 0.0 -1.1 -2.3 -1.4 -1.5 -1.7 -2.3 -1.9 -1.4 -1.5 -2.0 -1.2 -2.2 -0.2 -2.0 -1.4 -2.1
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 2.0 -0.6 -0.5 -0.5 -1.4 -0.5 0.7 0.0 0.2 -0.5 -0.5 -1.1 -1.2 -0.7 -0.4 -0.8 -0.4 -0.8 -0.5 -0.7 -0.1 -0.8 -0.6 -0.8
Qualifications: CSEs or equivalent 0.1 0.1 0.7 -0.6 -0.3 -0.3 -0.1 -0.4 -0.1 0.0 -0.9 -0.3 -0.3 -0.6 -0.0 0.0 -0.7 -0.3 -0.0 0.4 -0.3 -0.2 0.0 0.3 -0.3 0.2
Serious illness, injury or assault to yourself 1.4 1.7 3.2 1.5 1.3 1.2 0.8 1.4 -1.5 0.0 -0.4 1.1 1.2 0.8 0.9 1.6 1.6 1.3 1.7 1.8 1.3 1.6 -0.2 1.5 1.3 1.7
High blood pressure 2.3 6.3 13.2 2.4 2.6 2.6 2.3 2.6 -2.5 0.0 0.5 2.8 2.6 1.7 1.0 2.1 2.4 2.5 3.6 3.5 3.2 3.2 0.6 3.0 2.6 3.4
Hayfever, allergic rhinitis or eczema 7.0 15.1 22.5 4.3 4.3 4.3 3.3 4.2 -4.2 0.0 -0.1 3.7 4.3 4.2 4.7 4.2 4.0 4.0 4.3 4.5 3.8 3.8 1.3 4.5 4.2 4.0
Multivitamins +/- minerals 3.1 3.9 6.7 2.1 2.1 2.0 2.3 2.3 -2.0 0.0 0.3 2.2 2.0 1.4 1.5 2.5 2.0 2.0 2.1 2.2 1.7 2.4 0.2 2.3 2.0 2.6
Stomach or abdominal pain in last month 5.6 7.0 11.3 3.3 2.6 2.4 1.6 3.0 -2.8 0.0 -0.0 2.8 2.5 2.3 3.1 3.4 3.3 2.8 2.5 3.0 2.7 3.2 0.5 2.8 2.7 3.2
Supplements: Glucosamine 0.6 0.8 1.6 -0.9 -1.1 -1.2 -1.2 -1.1 1.0 0.0 -0.5 -0.8 -1.1 -1.0 -0.9 -0.7 -0.9 -0.8 -1.1 -0.7 -0.5 -1.0 -0.5 -0.7 -1.0 -0.9
Diverticular disease/diverticulitis (self-reported) 5.4 6.4 9.9 2.3 3.1 3.1 2.1 2.9 -2.9 0.0 0.8 2.3 3.1 3.0 2.7 2.4 2.4 2.9 2.5 2.6 2.9 2.4 1.8 2.3 3.1 2.4
Medication: Atenolol 0.2 0.3 2.3 0.7 0.2 0.2 -0.0 0.4 -0.3 0.0 1.5 0.9 0.2 0.3 0.0 0.6 0.7 0.2 0.4 0.3 0.1 0.7 1.0 0.4 0.2 0.0
Medication: Levothyroxine sodium 0.3 0.5 1.7 0.4 0.6 0.6 1.1 0.6 -0.7 0.0 -0.2 0.5 0.6 0.7 0.4 0.3 0.3 0.7 1.3 1.1 1.0 0.8 0.6 0.8 0.7 1.0
Sitting height 4.4 31.5 63.8 -6.2 -5.6 -5.5 -4.7 -5.9 5.5 0.0 4.1 -5.7 -5.6 -4.5 -5.4 -7.0 -6.2 -5.5 -4.3 -7.2 -5.7 -5.0 4.9 -8.0 -5.6 -6.5
Chronic bronchitis/emphysema (father) 0.3 0.3 2.0 0.5 -0.2 -0.3 0.4 -0.0 -0.1 0.0 -0.9 0.4 -0.2 -0.4 -0.2 0.4 0.5 0.2 0.3 1.0 1.0 0.5 -1.4 0.9 -0.0 0.5
High blood pressure (mother) 3.6 5.0 8.6 1.9 2.6 2.8 2.9 2.9 -2.4 0.0 0.9 2.5 2.7 1.9 1.9 2.5 2.0 2.2 2.1 2.2 1.8 2.7 1.4 2.2 2.5 2.1
Body mass index (BMI) 0.5 2.3 16.0 -1.2 -0.7 -0.9 -0.3 -0.9 0.5 0.0 3.8 -0.8 -0.7 -0.6 -1.2 -2.0 -1.0 -0.1 -0.2 -1.7 -0.2 -0.3 4.0 -2.3 -0.5 -1.3
Impedance of leg (left) 2.0 9.9 82.8 2.3 1.1 1.2 1.4 1.6 -0.9 0.0 -7.4 2.2 1.1 0.4 2.2 3.7 2.1 0.8 0.2 3.5 1.5 1.3 -9.1 4.6 1.0 2.9
Leg predicted mass (left) 4.8 25.3 57.9 -5.3 -4.3 -4.5 -3.7 -4.9 4.0 0.0 6.4 -4.9 -4.4 -3.5 -5.1 -6.7 -5.2 -3.9 -3.0 -6.5 -4.2 -3.9 7.6 -7.6 -4.2 -5.9
Trunk fat mass 1.1 4.9 9.8 -2.6 -2.4 -2.5 -1.4 -2.5 2.2 0.0 1.2 -2.1 -2.4 -2.5 -2.8 -3.1 -2.4 -1.9 -1.5 -2.6 -1.3 -1.8 1.1 -3.0 -2.2 -2.4
Waist circumference 1.4 5.1 11.4 -2.5 -2.2 -2.4 -1.2 -2.3 2.1 0.0 2.5 -1.8 -2.2 -2.4 -3.0 -3.1 -2.3 -1.7 -1.4 -2.9 -1.3 -1.4 2.1 -3.4 -2.1 -2.6
Number of incorrect matches in round 0.9 1.5 11.2 -1.2 -0.7 -0.7 0.1 -0.9 0.6 0.0 -3.3 -2.1 -0.7 -1.6 -0.7 -0.4 -1.2 -0.9 -0.5 -0.2 -1.2 -1.5 -2.0 0.2 -0.7 -0.1
Past tobacco smoking 0.2 0.4 4.5 0.4 -0.1 -0.2 -1.3 0.0 0.1 0.0 2.1 0.7 -0.1 0.2 0.1 0.5 0.4 -0.0 -0.4 -0.5 -0.6 0.3 1.3 -0.2 -0.1 -0.3
Alcohol usually taken with meals 2.1 3.3 6.7 1.6 2.1 2.0 2.0 1.9 -1.9 0.0 -0.6 1.4 2.1 1.7 1.6 1.7 1.5 2.1 2.0 2.3 2.0 1.7 -0.5 2.6 2.1 2.2
Nervous feelings 0.1 0.2 1.0 0.6 0.2 0.4 -0.6 0.5 -0.0 0.0 1.0 0.2 0.2 0.2 -0.6 0.3 0.5 -0.4 0.5 0.1 -0.3 0.4 1.0 -0.1 0.0 -0.0
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.1 1.4 1.1 1.1 0.9 1.2 -1.2 0.0 0.3 1.7 1.1 0.8 0.7 1.4 1.4 1.1 1.6 1.8 1.4 1.6 -0.2 1.8 1.1 1.7
Hearing difficulty/problems with background noise 0.6 1.0 3.6 0.3 1.2 1.3 1.1 1.0 -0.8 0.0 -1.7 0.0 1.2 0.6 -0.6 -0.2 0.6 1.1 1.9 1.2 1.5 0.5 -0.0 0.8 1.2 1.1
Hair/balding pattern: Pattern 2 0.6 0.8 2.6 1.2 0.9 0.8 0.3 1.2 -0.8 0.0 0.3 0.6 0.9 0.7 1.6 1.5 1.3 0.9 0.4 0.5 0.6 1.1 0.1 0.5 0.9 1.3
Had menopause 24.5 30.6 40.3 -5.9 -5.9 -5.7 -4.4 -5.9 6.3 0.0 -3.6 -5.7 -5.8 -5.6 -6.3 -6.3 -5.7 -5.9 -6.0 -5.6 -4.9 -5.8 -4.1 -5.8 -5.9 -6.2
Had other major operations 0.3 0.4 4.2 -0.3 0.2 0.1 2.1 0.4 -0.4 0.0 1.1 0.2 0.3 0.1 0.0 -0.1 -0.4 0.6 0.7 0.6 0.6 1.1 0.3 0.4 0.4 0.4
Forced vital capacity (FVC) 0.5 1.8 2.8 -1.3 -1.6 -1.7 -1.6 -1.6 1.5 0.0 0.2 -0.8 -1.6 -1.5 -1.3 -1.2 -1.2 -1.4 -1.3 -1.7 -1.4 -1.1 0.1 -1.6 -1.6 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.3 -2.1 -1.2 -1.2 -0.6 -1.4 1.4 0.0 -1.3 -2.0 -1.2 -1.7 -1.6 -2.0 -1.8 -1.1 -0.9 -1.5 -0.7 -1.7 -0.6 -1.6 -1.2 -1.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 2.2 0.2 -0.4 -0.5 0.2 -0.1 0.4 0.0 -0.2 -0.0 -0.4 -0.6 0.6 0.4 0.2 -0.1 -0.4 0.2 0.4 0.5 -1.5 0.3 -0.4 0.3
Qualifications: None of the above 0.4 0.8 4.9 -0.5 -0.7 -0.6 -0.2 -0.5 0.7 0.0 -2.2 -0.8 -0.7 -1.1 -0.7 -0.7 -0.6 -0.9 -1.0 -0.2 -0.0 -0.5 -2.1 -0.4 -0.7 -0.5
Financial difficulties in last 2 years 0.1 0.2 1.9 -0.0 -0.2 -0.1 -0.1 0.0 0.4 0.0 -0.6 0.2 -0.2 -0.7 0.5 0.2 0.1 -0.3 0.2 -0.2 -0.4 0.1 -1.4 0.2 -0.2 0.1
Mouth/teeth dental problems 0.1 0.1 0.7 0.1 -0.2 -0.2 -0.1 -0.4 0.2 0.0 -0.8 -0.5 -0.2 -0.1 0.3 0.2 0.1 -0.1 -0.2 0.0 -0.6 -0.9 -0.2 0.3 -0.2 0.2
Heart attack 1.0 1.3 2.6 1.2 1.2 1.2 1.2 1.3 -1.5 0.0 0.7 0.9 1.2 0.3 0.6 1.5 1.4 0.8 0.9 1.6 1.2 1.4 0.5 1.4 1.1 1.1
Allergy 2.8 6.4 10.6 -2.8 -2.7 -2.6 -1.8 -2.6 2.6 0.0 -0.0 -2.3 -2.7 -2.9 -2.9 -2.4 -2.6 -2.7 -3.3 -3.1 -2.8 -2.7 -1.2 -2.8 -2.6 -2.8
Pain all over the body in last month 2.2 2.3 6.9 1.2 1.5 1.3 2.0 1.4 -1.5 0.0 0.9 1.4 1.5 1.2 0.3 0.9 1.4 1.8 2.2 2.0 2.6 2.1 0.4 1.3 1.6 1.9
Diabetes (self-reported) 12.3 19.0 33.4 -5.7 -4.3 -4.3 -1.5 -4.5 4.3 0.0 0.5 -5.7 -4.3 -5.0 -4.9 -5.4 -5.4 -4.4 -3.8 -5.2 -4.2 -4.3 1.6 -5.8 -4.3 -4.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.6 0.7 0.9 1.0 1.3 0.8 -0.9 0.0 0.5 0.4 1.0 0.6 1.2 1.0 0.7 0.7 0.7 0.6 0.1 0.4 0.7 0.8 0.9 0.6
Medication: Ramipril 0.3 0.4 3.0 0.1 0.7 0.7 1.7 0.6 -0.6 0.0 -0.3 0.2 0.7 -0.1 0.0 0.3 0.2 0.4 0.5 0.8 0.6 0.6 -0.0 0.6 0.6 0.4
Medication: Simvastatin 6.3 9.2 18.6 3.2 2.6 2.7 2.4 3.1 -2.6 0.0 -2.0 3.5 2.7 1.9 2.3 3.6 3.2 2.6 2.8 4.1 3.6 3.6 -3.3 4.3 2.6 3.9
Fluid intelligence score 1.4 2.9 6.9 -1.7 -1.5 -1.5 -0.7 -1.5 1.7 0.0 2.6 -1.1 -1.5 -1.1 -0.8 -1.6 -1.8 -1.5 -1.5 -2.6 -2.2 -1.5 1.9 -2.2 -1.6 -2.2
Illnesses of siblings 3.3 4.7 12.2 -1.8 -2.1 -2.0 -3.5 -2.1 2.2 0.0 -1.0 -2.5 -2.0 -1.6 -1.7 -2.2 -1.8 -2.3 -3.0 -2.5 -2.1 -2.3 -1.2 -2.5 -2.1 -2.6
Neuroticism score 1.6 3.4 7.8 2.3 1.7 1.8 0.7 2.1 -1.6 0.0 2.8 2.4 1.7 1.7 1.1 2.3 2.3 1.5 1.9 1.4 1.3 2.6 1.9 1.3 1.6 1.9
Weight 3.1 15.4 35.2 -4.3 -3.6 -3.8 -2.7 -4.0 3.3 0.0 4.5 -3.8 -3.6 -3.2 -4.2 -5.3 -4.2 -3.1 -2.5 -5.1 -3.0 -3.0 5.1 -5.9 -3.5 -4.4
Impedance of arm (right) 3.6 17.0 87.4 3.4 2.4 2.6 2.2 2.8 -2.1 0.0 -8.7 2.8 2.5 1.4 4.1 5.0 3.4 2.0 1.4 5.2 3.0 1.9 -9.3 6.7 2.3 4.7
Arm fat percentage (right) 0.0 0.1 0.9 0.0 0.1 0.0 0.2 0.0 -0.2 0.0 0.7 0.2 0.1 -0.1 0.2 -0.4 0.2 0.5 0.5 0.1 0.9 0.3 0.7 0.0 0.2 0.3
Trunk fat-free mass 7.1 41.0 97.6 -6.6 -5.6 -5.8 -5.0 -6.1 5.2 0.0 7.9 -6.2 -5.7 -4.2 -6.3 -8.3 -6.7 -5.2 -4.1 -8.3 -5.8 -4.9 9.3 -9.9 -5.5 -7.5
Hip circumference 1.0 4.1 16.2 -2.4 -1.4 -1.5 -0.2 -1.6 1.3 0.0 3.4 -2.1 -1.4 -1.6 -2.1 -2.7 -2.2 -1.1 -1.1 -2.8 -1.2 -1.1 4.0 -3.2 -1.3 -1.9
Time employed in main current job 0.2 0.2 1.0 0.0 0.5 0.7 1.0 0.3 -0.3 0.0 -0.7 -0.2 0.5 -0.0 0.0 0.2 0.1 0.2 0.9 0.4 -0.1 -0.1 0.0 0.6 0.4 0.2
Alcohol intake versus 10 years previously 9.2 13.8 30.6 3.9 3.5 3.4 3.8 3.6 -3.6 0.0 -2.9 3.5 3.5 2.8 4.0 4.7 3.8 3.7 2.8 4.8 4.1 3.2 -3.2 5.5 3.6 4.4
Father’s age at death 0.2 0.3 1.3 0.8 0.6 0.6 -0.0 0.5 -0.4 0.0 0.3 0.7 0.6 1.1 -0.3 0.2 0.6 0.6 0.6 0.3 0.9 0.3 0.1 0.2 0.6 0.4
Worrier / anxious feelings 2.2 4.2 6.9 2.4 2.2 2.3 1.1 2.3 -2.2 0.0 2.6 2.2 2.2 2.6 1.7 1.8 2.2 1.8 2.2 1.9 1.8 2.3 2.3 1.5 2.1 1.6
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.9 4.1 1.4 1.2 1.1 0.7 1.4 -1.2 0.0 1.4 2.0 1.2 0.6 0.8 1.5 1.6 1.4 1.9 1.4 1.5 1.9 0.6 1.4 1.2 1.8
Falls in the last year 0.8 1.1 3.0 0.9 0.8 0.6 1.1 0.9 -1.1 0.0 -1.3 0.3 0.7 0.2 0.7 1.4 1.0 1.1 1.3 1.6 1.1 1.2 -1.0 1.6 0.8 1.7
Hair/balding pattern: Pattern 3 1.9 2.9 4.0 -1.9 -1.8 -1.8 -1.1 -1.8 1.9 0.0 -0.5 -2.0 -1.8 -1.9 -2.0 -1.7 -1.9 -1.9 -1.7 -2.0 -1.9 -1.6 -1.0 -1.6 -1.9 -1.6
Number of live births 0.7 1.0 2.7 0.7 0.9 0.9 0.6 0.8 -1.2 0.0 -0.7 0.6 0.9 0.7 1.1 0.5 0.7 1.0 1.6 1.6 1.6 0.9 -0.2 1.4 1.0 1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.9 -0.3 -0.9 -1.0 -1.3 -0.7 0.8 0.0 1.7 0.5 -1.0 -0.8 -0.4 -0.3 -0.2 -0.7 -0.7 -1.1 -0.9 0.0 0.7 -0.9 -0.9 -0.9
Pulse rate 6.4 10.8 22.3 3.6 3.1 3.1 1.1 3.1 -3.3 0.0 -2.0 3.8 3.2 3.1 3.6 3.6 3.5 3.3 2.8 4.3 3.8 2.9 -3.2 4.7 3.3 3.8
Happiness 0.6 0.7 3.6 0.6 0.6 0.5 1.9 0.7 -0.6 0.0 0.5 1.1 0.5 0.4 1.1 1.1 0.5 0.7 0.5 0.8 0.3 1.1 -0.4 1.1 0.6 0.9
Noisy workplace 0.3 0.4 1.8 -0.2 -0.6 -0.6 -0.2 -0.5 0.6 0.0 -1.3 -0.3 -0.6 -0.9 -0.6 0.2 -0.2 -0.7 -0.3 -0.3 -1.0 -0.5 -1.4 -0.1 -0.6 -0.1
Qualifications: A levels/AS levels or equivalent 0.4 1.0 4.1 0.8 1.2 1.3 0.2 0.9 -0.9 0.0 2.0 1.3 1.2 1.1 1.0 0.7 1.0 0.7 1.2 0.2 -0.1 0.3 1.7 0.4 1.0 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 3.4 -0.7 -0.5 -0.6 0.5 -0.6 0.4 0.0 -0.7 -0.3 -0.5 -0.7 0.2 -0.3 -0.9 -0.4 0.2 -0.2 -0.5 -0.2 -1.9 0.3 -0.5 0.2
Mouth/teeth dental problems: Dentures 1.1 1.9 8.0 -1.3 -0.9 -0.7 -0.4 -0.6 0.9 0.0 2.8 -0.8 -0.9 -0.9 -1.2 -1.5 -1.3 -1.3 -1.0 -2.1 -1.4 -0.4 2.1 -2.3 -0.9 -2.0
Asthma 0.1 0.2 1.5 0.1 -0.2 -0.3 -0.4 -0.3 0.1 0.0 -1.2 -0.5 -0.2 0.2 -0.2 -0.4 0.1 0.2 0.4 0.4 0.6 -0.2 -0.7 0.1 -0.1 0.5
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.2 12.2 1.2 2.3 2.3 3.5 2.3 -2.4 0.0 1.2 1.6 2.3 1.3 1.4 1.8 1.4 2.3 2.5 2.0 1.9 2.4 1.5 1.9 2.4 2.3
Medication: Cholesterol lowering 11.2 17.4 37.1 4.8 3.8 3.8 2.8 4.2 -3.9 0.0 -1.7 4.8 3.8 3.0 3.3 5.2 4.7 3.7 3.8 5.8 4.8 4.7 -3.6 6.1 3.8 5.1
Depression (self-reported) 0.1 0.1 1.5 -0.2 0.0 0.1 0.3 0.1 0.0 0.0 -0.9 -0.4 0.1 -0.5 0.2 0.2 -0.1 -0.3 -0.1 -0.2 -0.4 -0.1 -1.2 0.2 -0.0 -0.1
Medication: Lansoprazole 0.3 0.3 1.0 0.3 0.7 0.7 0.8 0.8 -0.6 0.0 0.6 0.6 0.7 0.1 -0.0 0.5 0.6 0.5 0.1 0.5 1.0 0.8 0.2 0.4 0.7 0.3
Prospective memory result 0.2 0.3 1.5 -0.5 -0.5 -0.4 0.4 -0.5 0.3 0.0 -1.2 -0.6 -0.5 -0.4 -0.4 -0.3 -0.7 -0.5 -0.4 -0.3 -0.6 -0.6 -0.7 -0.2 -0.4 -0.3
Lung cancer (father) 0.6 0.7 2.0 1.3 0.8 0.9 -1.4 0.7 -1.0 0.0 0.1 0.7 0.8 1.3 0.9 0.9 1.3 0.8 0.6 0.7 0.7 0.4 0.1 0.8 0.9 0.7
Illnesses of mother 2.7 3.3 6.4 -1.7 -2.0 -2.1 -2.0 -2.3 1.9 0.0 -2.2 -2.1 -2.1 -1.7 -1.5 -1.6 -1.7 -1.8 -1.8 -1.5 -1.4 -2.5 -1.7 -1.3 -1.9 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 3.0 -0.5 -1.0 -1.0 -1.0 -0.8 0.9 0.0 1.7 0.1 -1.0 -0.7 -0.5 -0.4 -0.6 -0.8 -0.9 -1.4 -1.0 -0.4 0.7 -1.1 -1.0 -0.9
Pulse wave Arterial Stiffness index 0.2 0.2 0.9 0.2 0.2 0.0 0.7 0.3 -0.2 0.0 1.0 0.9 0.1 -0.5 -0.6 0.2 0.5 0.4 0.1 0.4 0.3 0.9 0.6 0.0 0.2 0.4
Impedance of arm (left) 3.5 16.1 98.6 3.2 2.1 2.2 2.1 2.5 -1.7 0.0 -8.6 2.8 2.1 0.9 3.4 4.8 3.2 1.8 1.3 5.0 2.7 1.8 -9.9 6.5 1.9 4.5
Arm fat mass (right) 0.9 3.6 8.9 -2.0 -1.6 -1.8 -1.3 -1.9 1.5 0.0 2.7 -1.7 -1.6 -1.5 -2.0 -2.9 -1.9 -1.2 -0.8 -2.4 -1.0 -1.3 3.0 -2.9 -1.5 -2.0
Trunk predicted mass 7.3 41.7 99.0 -6.7 -5.7 -5.8 -5.0 -6.2 5.3 0.0 7.8 -6.3 -5.7 -4.3 -6.3 -8.4 -6.8 -5.3 -4.2 -8.4 -5.8 -5.0 9.2 -9.9 -5.6 -7.6
Standing height 3.9 38.3 68.7 -6.8 -6.5 -6.5 -5.2 -6.7 6.3 0.0 2.0 -6.7 -6.5 -5.7 -6.6 -7.5 -7.0 -6.4 -5.1 -7.5 -6.2 -5.8 2.9 -8.3 -6.5 -7.0
Length of working week for main job 0.8 0.9 2.0 -1.2 -0.9 -0.9 0.1 -0.9 0.9 0.0 0.1 -1.2 -0.9 -0.8 -0.7 -0.6 -1.2 -0.6 -1.3 -1.4 -1.1 -1.0 0.7 -1.4 -0.8 -0.7
Exposure to tobacco smoke at home 0.1 0.1 0.3 -0.5 -0.2 -0.4 0.5 -0.5 0.1 0.0 0.0 -0.3 -0.3 -0.5 -0.2 -0.1 -0.4 0.0 0.5 -0.1 -0.1 -0.3 0.0 0.2 -0.1 0.1
Breastfed as a baby 1.8 2.2 7.0 -1.8 -1.3 -1.4 0.5 -1.5 1.4 0.0 -2.7 -2.1 -1.3 -1.2 -0.8 -1.5 -1.9 -1.2 -1.7 -1.4 -1.2 -1.6 -1.8 -1.2 -1.2 -1.1
Tense / ‘highly strung’ 0.5 0.8 2.4 1.5 0.6 0.6 -0.5 0.9 -0.6 0.0 -0.5 1.1 0.6 0.5 0.1 1.6 1.5 0.5 0.6 1.3 0.6 1.2 -0.5 1.2 0.6 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 2.2 -0.6 -0.4 -0.5 1.2 -0.3 0.5 0.0 -1.2 -0.1 -0.4 -0.7 -0.4 -0.2 -0.5 -0.0 -0.3 -0.3 0.0 0.2 -1.5 -0.0 -0.3 0.1
Hair/balding pattern: Pattern 4 1.4 3.5 8.9 -2.3 -1.9 -1.9 -1.4 -2.1 1.8 0.0 -1.3 -2.0 -1.9 -2.0 -3.0 -2.7 -2.2 -1.9 -1.3 -1.2 -1.2 -1.9 -0.1 -2.0 -1.9 -1.7
Birth weight of first child 2.8 5.0 9.9 -2.2 -2.2 -2.3 -2.5 -2.4 2.0 0.0 -1.2 -2.7 -2.3 -1.4 -1.7 -2.0 -2.4 -2.1 -3.1 -2.7 -2.8 -2.8 -0.2 -2.2 -2.2 -2.9
Peak expiratory flow (PEF) 0.4 1.0 7.6 1.2 0.3 0.1 -0.4 0.5 -0.5 0.0 2.8 1.8 0.2 0.6 0.2 0.7 1.2 0.8 1.1 0.2 0.5 1.5 1.9 0.2 0.4 0.5
Pulse wave reflection index 2.1 2.6 5.4 -1.4 -1.7 -1.8 -0.8 -1.4 1.6 0.0 2.3 -0.7 -1.7 -2.0 -1.8 -1.3 -1.3 -1.5 -1.6 -2.2 -2.0 -0.9 1.5 -2.1 -1.6 -1.8
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.5 0.8 0.3 0.2 0.5 0.7 -0.5 0.0 1.4 1.0 0.3 0.2 0.1 0.6 0.7 0.4 0.7 0.6 0.6 1.6 0.6 0.3 0.3 0.6
Loud music exposure frequency 0.2 0.3 0.7 -0.3 -0.6 -0.6 -0.7 -0.6 0.4 0.0 -0.4 -0.7 -0.6 -0.5 -0.7 -0.5 -0.5 -0.6 0.2 -0.1 -0.1 -0.2 0.8 -0.5 -0.6 -0.3
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 13.5 0.9 1.5 1.6 2.2 1.3 -1.3 0.0 3.7 1.6 1.5 1.6 1.7 1.2 0.9 1.2 1.7 0.4 0.0 1.2 2.6 0.8 1.4 0.8
Mouth/teeth dental problems: Bleeding gums 3.9 5.1 12.1 2.3 2.1 2.1 1.2 2.3 -2.2 0.0 -0.5 2.5 2.1 1.4 1.5 2.4 2.4 2.2 2.5 3.5 3.1 2.9 -0.8 3.1 2.2 3.0
Blood clot in the leg (DVT) 0.2 0.3 1.8 -0.3 -0.1 -0.2 -0.3 -0.2 0.2 0.0 0.5 -0.7 -0.1 0.1 -0.8 -0.8 -0.3 0.1 0.6 0.3 0.8 0.2 1.4 -0.5 -0.1 0.1
Medication: Paracetamol 4.7 7.8 15.4 2.5 2.6 2.4 3.4 2.9 -2.9 0.0 1.4 3.2 2.6 1.7 2.1 2.8 2.7 3.0 3.3 3.7 3.4 3.9 0.8 3.2 2.7 3.7
Headache pain in last month 4.5 7.7 13.0 3.0 2.8 2.8 2.9 3.0 -2.9 0.0 0.5 3.3 2.8 2.6 3.5 3.6 2.9 2.7 2.4 3.1 2.7 3.0 -0.1 3.4 2.8 3.1
Medication for cholesterol, blood pressure or diabetes 4.8 8.0 15.2 -2.9 -3.0 -3.1 -2.5 -3.2 2.8 0.0 0.2 -3.1 -3.0 -2.0 -1.8 -3.0 -3.0 -2.6 -2.9 -3.9 -3.6 -3.4 1.0 -3.7 -2.9 -3.3
Glaucoma (self-reported) 0.2 0.2 1.8 0.2 -0.5 -0.4 -1.3 -0.2 0.4 0.0 0.6 -0.0 -0.4 -0.0 -0.2 0.1 0.1 -0.4 -0.9 -0.6 -0.6 -0.2 -0.3 -0.3 -0.5 -0.7
Gout (self-reported) 36.4 49.8 100.0 7.4 7.3 7.3 5.7 7.5 -7.5 0.0 -4.1 7.0 7.3 6.0 7.7 8.6 7.5 7.1 5.9 8.6 7.5 6.6 -4.4 10.0 7.4 7.8
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 1.8 -0.2 -0.1 -0.1 0.2 -0.2 0.0 0.0 -1.3 -0.1 -0.1 -0.2 -0.2 -0.2 -0.1 0.0 0.3 0.3 0.3 -0.0 -1.3 0.2 -0.1 0.4
Medication: Amlodipine 0.3 0.5 2.9 -0.4 0.7 0.8 1.7 0.7 -0.6 0.0 -0.8 -0.3 0.7 -0.5 -0.8 -0.1 -0.1 0.4 0.9 0.7 0.4 0.5 1.0 0.3 0.6 0.3
Medication: Ventolin 100micrograms inhaler 1.7 2.2 3.3 1.7 1.7 1.7 0.1 1.5 -1.5 0.0 0.5 1.5 1.8 1.8 1.0 1.2 1.8 1.7 1.6 1.8 1.8 1.2 0.6 1.6 1.8 1.8
Birth weight 0.1 0.3 1.3 0.0 0.3 0.0 0.9 0.1 -0.4 0.0 0.7 -0.1 0.2 0.7 0.6 -0.2 -0.1 0.7 0.6 0.4 0.9 0.7 1.1 0.1 0.4 0.5
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.7 0.9 1.2 1.1 1.6 1.2 -1.2 0.0 1.2 0.8 1.1 0.8 0.4 0.8 0.9 1.2 1.1 1.0 1.1 1.5 1.6 0.6 1.2 1.1
High blood pressure (siblings) 4.2 6.1 11.8 2.2 2.3 2.2 3.4 2.4 -2.4 0.0 -0.1 2.9 2.2 1.8 2.2 2.6 2.0 2.4 3.1 3.4 2.8 2.9 0.0 3.3 2.3 3.2
Forced vital capacity (FVC), Best measure 0.5 1.9 3.7 -1.4 -1.5 -1.5 -1.6 -1.4 1.5 0.0 0.8 -1.0 -1.5 -1.3 -1.4 -1.3 -1.4 -1.4 -1.4 -1.9 -1.4 -1.2 0.5 -1.9 -1.5 -1.4
Body fat percentage 0.1 0.2 1.8 -0.2 -0.3 -0.4 0.3 -0.3 0.2 0.0 -0.8 0.1 -0.3 -0.8 -0.5 -0.3 -0.0 0.2 0.1 0.2 0.9 0.2 -1.4 0.3 -0.2 0.2
Leg fat percentage (right) 0.0 0.1 0.8 -0.2 -0.3 -0.5 0.1 -0.3 0.2 0.0 -0.3 -0.0 -0.3 -0.5 -0.5 -0.5 -0.1 0.2 -0.1 0.0 0.9 0.2 -0.7 -0.1 -0.2 0.0
Arm fat-free mass (right) 7.4 38.2 90.6 -6.5 -5.6 -5.8 -4.3 -6.0 5.2 0.0 7.3 -5.8 -5.6 -4.5 -6.6 -8.2 -6.5 -5.1 -4.0 -8.0 -5.4 -4.6 8.1 -9.5 -5.4 -7.4
Exposure to tobacco smoke outside home 0.3 0.5 5.2 0.5 0.0 -0.0 -0.1 0.3 -0.3 0.0 2.3 1.1 -0.0 0.3 0.4 0.4 0.4 0.2 0.2 0.0 0.1 1.1 1.3 0.1 0.0 -0.0
Comparative body size at age 10 3.3 9.1 17.9 3.1 3.0 2.8 3.6 3.0 -3.2 0.0 0.7 3.2 3.0 2.7 4.2 3.9 3.1 3.4 2.1 3.1 3.0 3.0 -0.5 3.9 3.1 3.4
Number of full brothers 1.8 2.2 5.1 -1.7 -1.8 -2.0 -0.4 -1.8 1.6 0.0 -2.2 -1.9 -1.9 -1.7 -0.5 -1.2 -1.8 -1.4 -1.5 -0.9 -1.0 -1.4 -1.4 -0.9 -1.7 -1.4
Worry too long after embarrassment 1.6 2.7 13.2 1.8 1.5 1.7 -0.1 1.6 -1.3 0.0 3.6 1.5 1.5 2.0 1.7 1.5 1.7 1.2 1.8 0.1 0.4 1.4 3.1 0.2 1.3 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 6.1 -1.6 -2.0 -2.0 -1.8 -1.9 1.9 0.0 -1.7 -1.4 -2.0 -2.2 -1.8 -1.7 -1.3 -1.7 -2.0 -1.2 -1.0 -1.3 -2.5 -1.2 -1.9 -1.6
Wheeze or whistling in the chest in last year 1.0 1.8 3.7 1.5 1.4 1.2 -0.1 1.2 -1.4 0.0 1.9 1.5 1.4 1.6 0.8 1.1 1.6 1.7 1.5 1.1 1.8 1.2 1.5 0.9 1.5 1.3
Number of children fathered 0.9 1.0 3.1 -0.7 -1.0 -1.0 -0.7 -0.7 1.1 0.0 1.3 -0.4 -1.0 -1.1 -1.8 -1.0 -0.3 -0.8 -1.1 -1.3 -0.7 -0.1 1.3 -1.6 -0.9 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 2.5 3.0 5.2 -2.0 -1.7 -1.8 -1.3 -1.9 1.6 0.0 -0.5 -2.3 -1.7 -1.7 -2.1 -2.2 -1.9 -1.6 -1.4 -1.7 -1.9 -1.6 1.1 -2.1 -1.7 -2.1
Age at first live birth 0.8 1.5 3.0 1.0 1.6 1.6 1.7 1.4 -1.2 0.0 0.7 1.3 1.6 1.7 0.8 1.3 1.1 1.5 0.6 0.8 1.0 0.8 1.0 0.9 1.5 0.9
Pulse wave peak to peak time 0.5 0.6 2.0 -0.8 -0.6 -0.5 -0.9 -0.8 0.7 0.0 -0.6 -1.4 -0.6 -0.0 0.1 -0.8 -1.1 -0.9 -0.4 -1.0 -0.8 -1.3 -0.2 -0.7 -0.7 -0.9
Health satisfaction 4.8 6.3 8.9 2.8 2.7 2.7 2.1 2.9 -2.6 0.0 -0.3 2.4 2.7 2.3 2.5 2.9 2.7 2.6 2.5 3.0 2.8 2.8 -0.1 2.8 2.6 3.0
Shortness of breath walking on level ground 0.1 0.1 0.5 -0.2 -0.3 -0.3 -0.1 -0.2 0.4 0.0 -0.5 -0.4 -0.3 -0.7 -0.4 -0.0 -0.1 -0.4 -0.7 -0.2 -0.3 -0.2 -0.5 -0.5 -0.4 -0.0
Qualifications: College or University degree 0.3 0.8 1.6 0.9 1.1 1.0 1.2 0.9 -0.9 0.0 0.2 0.8 1.1 1.1 1.0 1.3 1.0 1.1 0.6 0.6 0.4 0.5 0.5 1.1 1.1 0.8
Eye problems/disorders: None of the above 4.1 4.8 7.2 -2.5 -2.4 -2.4 -1.5 -2.7 2.4 0.0 -1.3 -2.3 -2.5 -2.6 -1.6 -2.2 -2.7 -2.5 -1.9 -2.0 -2.4 -2.6 -1.8 -1.6 -2.4 -1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.3 0.3 0.4 0.4 0.9 0.5 -0.2 0.0 -0.7 0.6 0.4 0.3 0.4 0.4 0.3 0.5 0.1 0.9 1.1 0.7 -1.1 0.8 0.4 0.5
Emphysema/chronic bronchitis 0.3 0.4 1.2 -0.9 -0.4 -0.2 -0.8 -0.4 0.6 0.0 0.1 -0.5 -0.3 -0.3 -0.7 -1.1 -0.8 -0.4 -0.2 -1.0 -0.3 -0.4 0.2 -1.1 -0.4 -0.9
Medication for pain relief, constipation, heartburn 6.7 11.5 24.4 -2.8 -3.6 -3.6 -4.9 -3.9 3.6 0.0 -2.2 -3.5 -3.6 -2.1 -2.4 -3.4 -3.1 -3.5 -3.9 -3.6 -3.7 -4.4 -1.7 -3.3 -3.6 -4.1
Neck or shoulder pain in last month 0.3 0.4 1.9 0.1 0.0 -0.2 0.2 -0.0 -0.3 0.0 0.2 0.2 -0.1 -0.1 -0.9 -0.6 0.0 0.3 1.4 1.1 1.1 0.9 1.2 0.0 0.1 0.6
Medication: Blood pressure 1.1 1.9 4.2 1.1 1.4 1.5 1.5 1.5 -1.4 0.0 1.8 1.4 1.4 0.9 0.3 0.8 1.2 1.3 2.1 1.6 1.8 1.8 1.6 1.0 1.4 1.3
Angina (self-reported) 1.8 2.3 5.6 2.1 1.4 1.5 0.2 1.7 -1.4 0.0 0.8 2.0 1.4 0.8 0.5 1.9 2.4 1.2 1.2 2.0 1.9 2.0 -1.1 2.1 1.3 1.5
Migraine (self-reported) 0.6 0.7 2.3 0.5 1.0 1.2 1.5 1.4 -0.4 0.0 0.8 0.8 1.0 0.2 0.6 0.8 0.7 0.4 0.8 0.6 0.9 1.4 -0.2 0.7 0.8 0.6
Medication: Ibuprofen 2.1 2.5 9.2 0.9 1.7 1.7 3.0 1.8 -1.9 0.0 0.3 1.3 1.7 0.8 1.4 1.6 1.0 1.7 1.6 1.8 1.4 1.9 0.8 1.8 1.8 1.8
Medication: Allopurinol 24.5 32.6 74.1 5.8 5.6 5.7 4.7 5.7 -5.7 0.0 -4.4 5.7 5.7 4.7 6.1 6.8 5.8 5.6 4.7 7.3 6.2 5.0 -5.0 8.6 5.7 6.5
Medication: Omeprazole 0.4 0.5 2.4 0.5 0.7 0.7 0.8 0.7 -0.6 0.0 1.2 0.7 0.7 0.6 0.3 -0.0 0.5 0.4 0.9 0.5 0.6 0.9 1.5 -0.0 0.6 0.4
Medication: Seretide 50 evohaler 0.3 0.4 2.0 -0.7 -0.6 -0.8 -0.4 -0.9 0.5 0.0 -0.2 -1.4 -0.6 -0.3 -0.3 -0.6 -0.8 -0.3 -0.2 -0.7 -0.2 -0.8 0.0 -0.5 -0.5 -0.6
Mean time to correctly identify matches 0.3 0.6 1.8 0.9 1.0 1.0 0.6 0.7 -0.9 0.0 -0.5 -0.1 1.0 1.4 1.1 0.3 0.8 0.8 0.8 0.7 0.6 0.2 0.0 0.7 1.0 0.4
Heart disease (mother) 2.3 2.8 4.5 1.8 1.9 1.9 1.2 1.9 -1.8 0.0 1.0 2.1 1.9 1.9 1.5 1.5 1.7 1.9 1.8 1.9 1.6 2.1 0.2 1.7 1.9 1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.0 1.7 1.3 1.3 0.5 1.3 -1.4 0.0 0.1 1.7 1.3 1.6 0.7 1.3 1.6 1.1 1.3 1.2 1.1 1.0 0.8 1.2 1.2 0.8
Whole body fat mass 0.9 3.7 8.3 -2.2 -2.0 -2.1 -1.3 -2.1 1.8 0.0 1.6 -1.9 -2.0 -1.9 -2.4 -2.9 -2.1 -1.5 -1.1 -2.4 -1.0 -1.5 1.6 -2.8 -1.8 -2.1
Leg fat mass (right) 1.2 4.6 10.6 -2.3 -2.1 -2.2 -1.6 -2.3 1.9 0.0 2.2 -2.0 -2.1 -1.9 -2.7 -3.3 -2.2 -1.6 -1.2 -2.7 -1.1 -1.5 2.1 -3.3 -2.0 -2.4
Arm predicted mass (right) 7.0 36.0 86.7 -6.3 -5.3 -5.5 -4.1 -5.7 4.9 0.0 7.5 -5.6 -5.3 -4.2 -6.4 -7.9 -6.3 -4.8 -3.7 -7.8 -5.2 -4.3 8.5 -9.3 -5.1 -7.2
Pulse rate, automated reading 10.0 32.3 71.2 6.3 5.2 5.0 2.7 5.3 -5.4 0.0 -4.3 6.0 5.2 5.1 6.4 6.6 6.1 5.7 4.5 7.5 6.5 5.1 -5.7 8.4 5.4 6.8
Alcohol intake frequency. 20.5 47.7 110.2 7.2 6.0 5.8 5.5 6.5 -6.4 0.0 -6.5 6.4 6.0 4.9 7.7 9.1 7.1 6.6 4.5 8.9 7.6 6.2 -8.1 10.5 6.2 8.5
Comparative height size at age 10 3.8 20.9 43.7 -4.7 -4.4 -4.4 -3.7 -4.6 4.3 0.0 3.3 -4.9 -4.5 -3.8 -4.3 -5.4 -4.9 -4.5 -3.3 -5.9 -5.1 -4.2 4.7 -6.6 -4.5 -5.4
Number of full sisters 0.1 0.1 0.6 0.3 -0.3 -0.4 -0.1 -0.3 0.1 0.0 0.5 0.8 -0.3 0.0 -0.1 0.0 0.2 -0.1 -0.0 0.1 0.1 0.2 0.0 0.2 -0.2 -0.2
Suffer from ‘nerves’ 0.2 0.3 2.7 0.5 -0.1 -0.0 -0.2 0.3 0.3 0.0 1.6 0.6 -0.1 0.0 0.1 0.2 0.5 -0.2 0.2 -0.4 -0.5 0.8 0.8 -0.5 -0.2 -0.1
Overall health rating 3.5 7.6 14.4 3.4 2.4 2.2 0.8 2.7 -2.9 0.0 0.7 3.5 2.4 2.0 1.6 3.1 3.4 2.8 3.5 3.8 3.5 3.6 0.3 3.3 2.6 3.4
Chest pain or discomfort 1.6 2.3 4.1 1.7 1.5 1.5 0.1 1.6 -1.7 0.0 -0.5 1.7 1.5 1.4 1.5 2.0 1.8 1.8 1.4 1.7 1.6 1.6 0.3 2.0 1.5 1.9
Had major operations 0.7 0.8 3.1 0.7 1.1 1.2 0.9 1.2 -0.6 0.0 -0.5 0.9 1.1 0.9 -0.1 0.3 0.9 1.0 1.1 1.1 1.8 1.0 -0.2 0.6 1.0 1.0
Age at last live birth 0.1 0.2 2.0 -0.3 0.4 0.3 0.8 0.2 -0.2 0.0 -1.4 -0.1 0.4 0.2 -0.2 0.1 -0.1 0.5 -0.2 0.0 0.4 -0.4 -0.7 0.1 0.4 0.0
Family relationship satisfaction 2.6 3.1 5.2 -1.9 -2.0 -2.0 -0.8 -1.9 2.0 0.0 0.3 -1.7 -2.0 -1.8 -2.1 -2.2 -2.0 -1.9 -2.0 -1.8 -1.6 -1.6 -0.1 -2.3 -2.0 -2.0
Leg pain on walking 0.3 0.3 1.3 -0.5 -0.5 -0.5 -0.5 -0.2 0.6 0.0 1.0 -0.0 -0.5 -0.9 -0.9 -0.7 -0.3 -0.5 0.4 -0.1 -0.2 0.4 1.2 -1.0 -0.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 5.8 1.6 1.3 1.2 1.1 1.5 -1.7 0.0 0.7 1.6 1.3 1.2 1.4 1.6 1.4 1.6 2.4 2.0 2.1 2.2 0.5 1.7 1.4 1.8
Commuting to job workplace: Car/motor vehicle 0.6 0.7 4.5 0.1 0.9 1.0 2.1 1.0 -0.7 0.0 -0.8 0.1 1.0 0.2 0.1 0.1 0.4 0.7 0.9 1.0 0.8 1.1 -0.7 0.5 0.9 0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.7 -0.9 -0.2 -0.2 -0.5 -0.6 0.4 0.0 -0.3 -1.3 -0.2 0.1 -0.6 -1.1 -0.8 -0.2 -0.2 -0.4 -0.1 -1.1 0.8 -0.6 -0.1 -0.6
Medication: Aspirin 1.1 1.5 3.6 1.2 1.3 1.3 1.9 1.6 -1.4 0.0 -0.3 1.3 1.3 0.4 0.6 1.9 1.4 0.9 1.0 1.4 1.1 1.4 -0.4 1.6 1.2 1.3
Supplements: Vitamin C 0.4 0.5 3.4 -0.1 0.6 0.4 1.9 0.4 -0.7 0.0 -0.2 -0.1 0.5 0.3 0.1 -0.2 -0.2 0.8 1.2 0.9 1.1 0.8 0.8 0.3 0.7 0.8
Knee pain experienced in last month 0.4 0.7 3.1 -1.1 -0.8 -0.6 0.5 -0.5 0.8 0.0 -1.4 -0.5 -0.7 -1.8 -1.5 -0.5 -0.9 -1.0 -0.0 0.0 -0.4 -0.4 -0.8 -0.2 -0.8 0.0
Hypertension (Self-reported) 2.2 6.0 12.9 2.2 2.5 2.5 2.5 2.6 -2.5 0.0 0.9 2.6 2.5 1.7 1.0 1.9 2.3 2.4 3.6 3.3 3.1 3.1 1.1 2.7 2.5 3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.2 0.8 1.0 1.1 1.0 1.1 -1.0 0.0 -0.2 0.7 1.0 1.0 0.7 0.8 0.8 0.7 0.6 0.9 1.1 1.0 0.3 0.7 1.0 0.5
Illnesses of father: Heart disease 2.5 3.5 7.5 2.2 1.4 1.2 1.5 1.6 -1.6 0.0 -0.7 2.0 1.4 1.5 1.7 2.1 2.0 1.9 1.7 2.7 2.4 2.4 -1.7 2.7 1.5 2.6
Illnesses of siblings: Diabetes 1.1 1.4 12.0 -0.6 -0.4 -0.4 -0.6 -0.7 0.3 0.0 2.5 -0.6 -0.4 -0.1 -1.2 -1.1 -0.6 -0.6 0.3 -1.2 -1.3 -0.8 3.5 -1.7 -0.5 -1.1
Smoking status: Previous 0.3 0.5 4.8 -0.6 -0.0 0.0 1.2 -0.2 0.1 0.0 -2.2 -1.1 -0.0 -0.3 -0.4 -0.8 -0.6 -0.1 0.3 0.4 0.6 -0.6 -1.0 0.1 0.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 4.9 -1.9 -1.8 -1.8 -1.2 -1.9 1.7 0.0 0.3 -1.8 -1.8 -1.1 -1.6 -2.1 -2.2 -1.6 -1.4 -1.8 -1.7 -1.6 0.9 -1.8 -1.7 -1.8
Whole body fat-free mass 6.5 37.1 87.6 -6.3 -5.3 -5.4 -4.5 -5.8 4.9 0.0 7.7 -5.8 -5.3 -4.0 -6.1 -8.0 -6.3 -4.9 -3.8 -7.9 -5.3 -4.6 9.0 -9.4 -5.2 -7.2
Leg fat-free mass (right) 4.6 24.5 63.5 -5.1 -4.1 -4.2 -3.4 -4.6 3.8 0.0 7.0 -4.6 -4.2 -3.4 -4.9 -6.5 -5.1 -3.8 -2.9 -6.4 -4.2 -3.7 8.0 -7.5 -4.0 -5.8
Arm fat percentage (left) 0.0 0.1 0.7 -0.1 -0.0 -0.1 0.2 -0.1 -0.0 0.0 0.8 0.3 -0.0 -0.4 -0.2 -0.5 0.1 0.4 0.4 0.1 0.9 0.3 0.4 -0.0 0.1 0.2
Average weekly red wine intake 0.5 0.8 2.3 -1.2 -0.4 -0.3 0.1 -0.6 0.7 0.0 0.4 -1.3 -0.4 -0.7 -1.2 -1.5 -1.1 -0.9 -0.3 -0.8 -0.8 -0.8 1.4 -1.3 -0.6 -1.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.3 -0.7 -1.0 -1.0 -0.5 -1.0 1.0 0.0 0.4 -0.1 -1.1 -0.6 -0.8 -0.7 -0.8 -1.0 -0.8 -1.0 -1.5 -0.5 -1.0 -0.6 -1.1 -0.9
Mood swings 2.5 4.5 8.7 2.3 2.2 2.2 1.9 2.5 -2.1 0.0 1.8 2.7 2.2 1.8 1.3 2.3 2.4 2.0 2.0 2.2 2.5 2.9 1.2 2.0 2.1 2.2
Loneliness, isolation 1.6 2.2 5.2 2.2 1.5 1.5 0.2 1.8 -1.4 0.0 -0.2 1.6 1.5 1.7 0.7 1.9 2.3 1.5 1.1 1.7 1.8 1.9 0.1 1.5 1.5 1.6
Long-standing illness, disability or infirmity 0.3 0.5 1.0 0.7 0.7 0.7 1.0 0.9 -0.8 0.0 -0.6 0.3 0.7 -0.0 0.1 0.8 0.8 0.6 0.9 0.8 0.8 0.9 0.5 0.5 0.6 1.0
Ever had bowel cancer screening 1.3 1.5 3.9 1.0 1.2 1.2 1.2 1.0 -1.3 0.0 -1.9 0.5 1.2 1.0 0.8 1.1 1.0 1.3 1.0 2.0 1.7 0.8 -1.0 1.8 1.4 1.4
Diabetes diagnosed by doctor 12.6 20.7 39.0 -5.7 -4.4 -4.4 -2.1 -4.6 4.4 0.0 1.6 -5.6 -4.5 -5.0 -5.2 -5.6 -5.4 -4.6 -3.8 -5.5 -4.4 -4.3 2.6 -6.2 -4.5 -4.8
Ever had stillbirth, spontaneous miscarriage or termination 4.0 4.2 6.2 2.0 2.2 2.1 1.8 2.3 -2.2 0.0 0.9 2.4 2.2 2.0 2.1 2.0 2.0 2.4 2.5 2.1 2.3 2.5 0.3 2.1 2.3 2.4
Friendships satisfaction 0.0 0.0 0.4 0.1 0.1 -0.1 -0.2 0.1 -0.1 0.0 -0.2 0.2 0.0 0.2 0.3 0.1 -0.0 0.2 -0.0 0.3 0.2 0.4 -0.6 0.3 0.1 0.0
Qualifications: nursing, teaching 1.3 1.9 5.7 0.5 1.8 1.8 2.4 1.4 -1.6 0.0 1.1 1.0 1.9 1.6 0.7 0.9 0.7 1.9 1.7 0.6 1.2 0.9 1.2 0.9 1.8 1.6
Commuting to job workplace: Walk 0.1 0.1 0.6 0.1 -0.4 -0.4 0.8 -0.3 0.3 0.0 -0.0 0.0 -0.4 0.2 0.7 0.4 -0.3 -0.5 -0.5 -0.3 -0.7 -0.1 -0.3 0.3 -0.5 -0.1
Eye problems/disorders: Cataract 7.6 8.8 12.2 3.0 3.3 3.2 2.9 3.4 -3.3 0.0 0.7 2.9 3.3 3.1 2.6 3.3 3.3 3.5 2.7 3.1 3.4 3.2 1.7 2.8 3.3 3.2
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 2.8 0.9 1.1 1.1 1.0 1.1 -1.2 0.0 -0.7 1.1 1.1 0.9 1.0 1.1 0.9 1.2 1.7 1.2 1.4 1.0 -0.2 1.2 1.2 1.3
Medication for cholesterol 4.4 6.7 15.1 -2.0 -2.3 -2.1 -3.6 -2.4 2.2 0.0 2.2 -2.7 -2.2 -1.0 -1.5 -2.9 -2.1 -2.5 -2.4 -3.7 -3.2 -2.7 2.5 -3.9 -2.3 -3.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 4.9 1.1 1.2 1.2 1.6 1.6 -1.3 0.0 -2.2 1.0 1.2 -0.1 1.7 2.0 1.3 1.3 0.8 1.7 1.7 1.7 -2.2 1.9 1.2 1.9
Back pain experienced in last month 1.0 1.4 4.0 1.2 1.0 1.0 0.5 1.2 -1.1 0.0 2.0 1.6 0.9 0.8 0.3 0.7 1.1 0.9 1.5 1.6 1.6 1.8 1.8 0.8 1.0 1.1
Mineral and other dietary supplements 0.1 0.1 0.5 -0.2 -0.0 0.1 -0.3 -0.1 -0.0 0.0 0.6 -0.4 0.0 -0.1 0.3 -0.3 -0.1 -0.4 -0.3 -0.6 -0.7 -0.5 0.6 -0.3 -0.1 -0.4
Breast cancer (self-reported) 0.1 0.2 0.6 0.4 0.6 0.8 0.5 0.7 -0.3 0.0 0.1 0.3 0.7 0.7 -0.2 0.0 0.4 0.3 0.0 -0.0 0.2 0.3 0.4 -0.1 0.5 -0.2
Asthma (self-reported) 0.1 0.3 2.0 0.4 0.1 0.0 -0.2 -0.0 -0.2 0.0 -1.4 -0.3 0.2 0.4 0.4 -0.0 0.3 0.4 0.5 0.8 0.8 -0.1 -0.7 0.5 0.2 0.8
Osteoporosis (self-reported) 4.8 5.9 10.5 2.5 2.4 2.2 2.6 2.5 -2.4 0.0 -0.5 2.6 2.4 1.9 2.7 3.0 2.7 2.7 1.8 2.8 3.0 2.4 -1.3 3.2 2.5 3.0
Osteoarthritis (self-reported) 0.5 0.6 1.9 -1.3 -0.5 -0.7 1.2 -0.7 0.4 0.0 -1.1 -1.1 -0.6 -1.3 -0.8 -1.0 -1.1 -0.1 0.3 0.2 0.4 -0.3 -1.4 -0.1 -0.4 -0.1
Medication: Aspirin 1.3 1.6 3.4 1.3 1.4 1.5 1.9 1.7 -1.5 0.0 -0.3 1.2 1.4 0.8 0.5 1.8 1.4 1.1 1.1 1.4 1.3 1.4 -0.2 1.4 1.3 1.2
Medication: Gliclazide 4.1 4.6 8.9 -2.3 -1.9 -1.9 -2.1 -2.2 2.0 0.0 -0.1 -2.9 -1.9 -1.5 -2.1 -2.8 -2.3 -2.2 -2.0 -2.6 -2.3 -2.5 0.7 -3.0 -2.0 -2.7
Illnesses of father: None of the above (group 1) 0.4 0.5 3.3 -0.1 0.9 1.1 -0.1 0.7 -0.5 0.0 1.4 -0.0 0.9 0.7 0.9 0.1 0.2 0.4 0.3 -0.7 -0.2 -0.2 1.8 -0.5 0.8 0.0
Smoking status: Current 0.3 0.5 1.8 1.1 0.3 0.4 -1.0 0.4 -0.5 0.0 -0.7 1.0 0.3 0.5 0.5 0.8 0.8 0.4 0.3 0.7 0.4 0.5 -1.3 1.0 0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.6 0.7 0.7 0.8 0.5 0.7 -0.6 0.0 0.5 1.3 0.7 0.6 0.7 0.7 0.7 0.6 0.7 0.7 0.2 0.7 -0.7 1.0 0.7 0.6
Whole body water mass 6.6 37.6 89.1 -6.3 -5.3 -5.5 -4.6 -5.8 4.9 0.0 7.9 -5.8 -5.4 -4.1 -6.1 -8.1 -6.4 -4.9 -3.8 -8.0 -5.4 -4.6 9.2 -9.4 -5.2 -7.2
Leg predicted mass (right) 4.6 24.7 64.3 -5.1 -4.2 -4.3 -3.5 -4.7 3.8 0.0 7.0 -4.6 -4.2 -3.4 -5.0 -6.5 -5.1 -3.8 -2.9 -6.4 -4.2 -3.7 8.0 -7.5 -4.0 -5.8
Arm fat mass (left) 0.9 3.6 9.0 -2.0 -1.6 -1.8 -1.2 -1.9 1.5 0.0 2.9 -1.6 -1.7 -1.6 -2.1 -2.9 -1.9 -1.2 -0.8 -2.4 -1.0 -1.1 3.0 -2.9 -1.5 -2.0
Number of self-reported non-cancer illnesses 7.3 12.7 23.5 3.7 3.6 3.6 3.2 3.7 -3.6 0.0 -1.5 3.4 3.6 2.9 3.0 3.7 3.8 3.6 3.5 4.8 4.5 3.9 -1.8 4.7 3.6 4.5
Average weekly champagne plus white wine intake 0.6 0.8 4.6 -0.7 -0.3 -0.3 -0.9 -0.6 0.2 0.0 2.0 -0.6 -0.3 -0.1 -0.8 -1.2 -0.5 -0.3 0.1 -1.2 -0.9 -0.7 2.1 -1.2 -0.3 -1.1
Miserableness 2.1 3.6 6.5 2.1 1.7 1.8 1.3 2.1 -1.8 0.0 1.1 2.4 1.7 1.4 2.0 2.5 2.2 1.7 1.7 2.2 2.2 2.5 -0.1 2.4 1.8 2.3
Guilty feelings 0.4 0.6 8.0 0.4 -0.3 -0.4 -0.5 0.0 0.0 0.0 2.8 0.8 -0.4 -0.5 -0.3 0.7 0.4 -0.4 0.2 -0.2 -0.8 0.7 1.5 -0.2 -0.3 0.4
Wears glasses or contact lenses 0.1 0.1 0.5 -0.1 0.6 0.5 0.7 0.4 -0.4 0.0 -0.1 0.1 0.6 0.0 -0.4 0.1 0.2 0.5 0.4 0.4 0.5 0.2 -0.1 0.1 0.6 0.5
Ever taken oral contraceptive pill 0.4 0.4 3.7 -0.6 0.6 0.7 -0.1 0.2 -0.6 0.0 1.1 -0.8 0.6 -0.0 0.1 -0.6 -0.5 0.1 0.8 -0.2 -0.2 -0.3 1.9 -0.4 0.5 -0.1
Hearing aid user 1.7 1.9 4.8 2.2 1.5 1.7 -0.6 1.5 -1.4 0.0 0.1 1.8 1.5 1.9 1.1 1.4 1.9 0.9 1.4 1.8 1.1 1.2 -0.2 1.9 1.3 0.9
Mother’s age at death 1.3 1.6 4.1 -1.6 -0.9 -0.7 -0.1 -1.2 1.3 0.0 -1.9 -2.0 -0.9 -1.2 -0.9 -1.5 -1.6 -1.4 -1.0 -1.2 -1.2 -1.7 -1.6 -1.1 -1.1 -0.8
Financial situation satisfaction 0.3 0.4 2.7 0.1 0.7 0.7 1.6 0.8 -0.6 0.0 0.6 0.4 0.8 0.2 0.3 0.4 0.2 0.7 0.4 0.4 0.7 0.9 0.6 0.4 0.7 0.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.7 0.7 1.2 1.3 0.2 1.1 -1.1 0.0 -0.1 0.6 1.2 1.0 0.7 0.7 0.8 0.9 1.3 1.0 0.8 0.7 0.5 0.8 1.1 1.0
Commuting to job workplace: Public transport 1.2 1.4 4.3 -0.8 -1.5 -1.5 -2.1 -1.4 1.4 0.0 0.5 -0.2 -1.5 -0.9 -0.9 -0.7 -0.9 -1.3 -0.9 -1.5 -1.7 -1.3 -0.2 -0.9 -1.5 -1.1
Eye problems/disorders: Glaucoma 0.2 0.3 1.3 0.1 -0.3 -0.3 -1.2 -0.2 0.3 0.0 1.0 -0.1 -0.3 -0.1 -0.4 0.0 0.2 -0.4 -0.8 -0.8 -0.8 -0.3 0.4 -0.6 -0.4 -0.7
Medication: Blood pressure 1.3 2.4 5.2 1.2 1.6 1.6 2.1 1.7 -1.4 0.0 -0.9 1.7 1.6 0.5 0.4 1.6 1.3 1.4 1.7 2.3 1.9 1.8 -0.7 2.1 1.5 2.2
Pain type(s) experienced in last month: Hip pain 1.0 1.3 4.2 -1.7 -1.2 -1.1 -0.4 -1.1 1.1 0.0 0.0 -1.6 -1.2 -2.0 -1.7 -1.3 -1.4 -1.3 -0.2 -1.0 -0.8 -0.9 0.1 -1.2 -1.2 -0.8
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.7 0.9 1.1 1.1 1.2 1.3 -1.0 0.0 -0.3 1.0 1.1 0.8 0.4 1.1 0.9 1.2 1.0 1.3 1.3 1.3 0.2 0.9 1.1 1.2
High cholesterol (Self-reported) 24.8 43.9 93.7 7.6 6.1 6.0 4.2 6.7 -6.1 0.0 -3.6 7.7 6.1 5.3 6.0 8.5 7.4 6.2 5.8 8.8 7.1 6.9 -5.8 9.7 6.1 8.2
Medication: Bendroflumethiazide 0.2 0.3 1.0 0.4 0.6 0.7 0.4 0.8 -0.4 0.0 -0.2 1.0 0.6 0.1 0.1 0.5 0.4 0.3 0.6 0.9 0.4 0.9 -0.5 0.7 0.5 0.4
Medication: Paracetamol 3.2 4.9 10.8 2.1 2.0 1.8 2.7 2.3 -2.2 0.0 0.5 2.6 1.9 1.0 1.2 2.4 2.2 2.2 2.3 3.2 2.9 3.3 -0.1 2.8 2.1 2.9
Medication: Lisinopril 0.5 0.7 7.8 0.3 0.5 0.5 -0.3 0.5 -0.3 0.0 2.8 0.3 0.5 0.2 -0.6 0.1 0.5 0.4 1.2 -0.2 0.5 0.6 1.5 -0.3 0.5 0.6
Medication: Atorvastatin 15.4 19.0 38.3 5.1 4.2 4.2 3.0 4.6 -4.4 0.0 -1.6 4.9 4.2 3.4 3.9 5.9 5.0 4.2 3.7 5.5 4.7 4.3 -3.1 6.2 4.2 5.4
Illnesses of father: High blood pressure 1.4 1.8 3.4 1.2 1.3 1.2 1.8 1.2 -1.4 0.0 1.4 1.7 1.3 1.3 0.6 1.1 0.9 1.4 1.8 1.6 1.2 1.6 0.8 1.5 1.4 1.6
Alcohol drinker status: Never 0.5 0.6 4.1 0.6 0.1 0.0 -0.2 0.3 -0.4 0.0 -1.7 0.7 0.1 0.1 0.3 0.8 0.8 0.7 -0.0 0.9 1.1 0.7 -2.0 0.9 0.3 1.0
Ever smoked 0.2 0.4 3.8 -0.3 -0.0 0.0 1.1 -0.1 -0.0 0.0 -1.9 -0.5 -0.0 -0.4 0.1 -0.2 -0.4 -0.1 0.3 0.4 0.3 -0.3 -1.3 0.3 0.0 0.2
Basal metabolic rate 5.6 31.0 72.6 -5.8 -4.9 -5.0 -4.0 -5.4 4.5 0.0 7.2 -5.2 -4.9 -3.8 -5.6 -7.4 -5.8 -4.4 -3.4 -7.2 -4.7 -4.2 8.3 -8.5 -4.7 -6.5
Leg fat percentage (left) 0.0 0.1 0.8 -0.0 -0.1 -0.2 0.4 -0.1 -0.1 0.0 0.3 0.2 -0.1 -0.4 -0.4 -0.4 0.1 0.3 0.2 0.1 0.9 0.4 -0.2 -0.1 0.0 0.0
Arm fat-free mass (left) 6.5 33.0 80.3 -6.0 -5.0 -5.2 -4.1 -5.4 4.7 0.0 7.1 -5.4 -5.1 -4.0 -5.9 -7.6 -6.0 -4.6 -3.6 -7.5 -4.9 -4.2 8.2 -9.0 -4.9 -6.8
Number of operations (self-reported) 2.6 3.8 12.7 1.0 2.0 2.0 3.6 2.1 -1.7 0.0 0.6 1.8 2.0 1.5 1.0 0.9 1.2 2.1 2.3 2.5 3.2 2.6 -0.1 1.9 2.0 2.2
Average weekly beer plus cider intake 1.2 1.7 4.1 -0.8 -1.6 -1.5 -1.8 -1.4 1.6 0.0 0.3 -0.1 -1.5 -1.4 -2.0 -1.0 -0.7 -1.4 -1.5 -1.3 -1.4 -1.2 -0.4 -1.3 -1.6 -1.2
Irritability 1.7 2.8 5.2 2.1 1.8 1.9 -0.1 1.9 -1.8 0.0 2.2 1.8 1.9 1.7 0.7 1.8 2.3 1.5 2.0 1.2 1.2 1.9 1.9 1.2 1.7 1.6
Risk taking 0.4 0.6 3.1 -0.8 -0.8 -1.0 0.2 -0.8 0.6 0.0 -0.6 -0.9 -0.8 -1.8 -1.2 -0.1 -0.6 -0.4 -0.9 -0.5 0.1 -0.5 -0.8 -0.1 -0.7 -0.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.9 -0.1 0.3 0.2 0.2 0.2 -0.2 0.0 1.4 0.2 0.3 0.4 -0.6 -0.5 0.1 0.6 0.9 0.0 0.6 0.5 1.3 -0.3 0.5 0.4
Fractured/broken bones in last 5 years 2.5 3.2 4.8 1.6 2.0 1.9 2.1 1.9 -2.1 0.0 1.5 1.4 2.0 1.8 1.5 1.8 1.7 2.2 1.9 1.6 2.1 1.5 1.9 1.4 2.1 1.8
Age started oral contraceptive pill 0.1 0.1 0.5 0.3 0.1 0.1 -0.6 -0.0 -0.0 0.0 -0.7 -0.3 0.1 0.6 0.1 0.4 0.2 0.1 -0.7 -0.3 -0.2 -0.7 -0.6 0.2 0.1 -0.4
Diastolic blood pressure, automated reading 0.5 1.4 6.3 0.1 1.0 1.0 2.5 0.9 -0.7 0.0 2.0 1.4 1.1 0.8 0.1 0.0 0.2 1.3 1.6 0.7 1.4 1.6 1.6 0.3 1.1 1.2
Ever depressed for a whole week 0.2 0.3 2.2 -0.1 -0.7 -0.8 -0.4 -0.5 0.7 0.0 -0.6 -0.4 -0.7 -0.6 -0.2 -0.3 -0.2 -0.4 -0.4 -0.1 0.0 0.2 -1.5 -0.1 -0.6 -0.0
Unable to work because of sickness or disability 3.1 4.0 8.9 -1.8 -2.4 -2.4 -2.0 -2.0 2.1 0.0 -1.2 -1.7 -2.3 -3.0 -2.2 -1.6 -1.7 -2.2 -2.2 -1.8 -2.4 -1.5 -2.0 -1.6 -2.3 -2.0
Commuting to job workplace: Cycle 0.3 0.3 1.2 -0.4 -0.7 -0.9 0.5 -0.5 0.6 0.0 1.1 -0.2 -0.8 -0.5 0.2 -0.2 -0.5 -0.3 -0.9 -0.7 -0.2 -0.0 0.9 -0.6 -0.7 -0.4
Myopia 0.3 0.5 1.5 -0.8 -0.7 -0.8 0.3 -0.7 0.6 0.0 -1.2 -0.6 -0.7 -1.2 -0.3 -0.1 -0.9 -0.6 -1.1 0.0 -0.2 -0.5 -1.2 0.1 -0.7 -0.1
Vascular/heart problems diagnosed by doctor 2.5 6.7 13.2 -2.5 -2.6 -2.6 -2.4 -2.8 2.6 0.0 -0.5 -3.0 -2.6 -1.6 -0.8 -2.4 -2.7 -2.4 -3.4 -3.6 -3.3 -3.4 -0.2 -3.1 -2.6 -3.4
Cholesterol lowering medication 10.5 15.5 31.6 4.2 3.7 3.7 2.6 4.0 -3.6 0.0 -2.5 4.5 3.7 2.9 3.7 4.8 4.3 3.7 3.4 5.0 4.5 3.9 -3.9 5.6 3.7 5.0
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.4 1.1 1.3 1.5 1.0 1.4 -1.1 0.0 0.8 1.4 1.3 1.2 0.8 0.7 1.2 1.0 1.5 1.1 1.3 1.4 1.0 0.8 1.2 1.1
Pain experienced in last month 2.0 3.4 7.2 -1.7 -1.7 -1.6 -2.0 -1.8 2.0 0.0 -0.8 -2.0 -1.7 -1.1 -0.9 -1.7 -1.8 -1.9 -2.4 -2.7 -2.5 -2.5 -1.1 -2.0 -1.8 -2.2
Supplements: Calcium 0.6 0.6 3.0 0.1 0.2 0.0 1.1 0.3 -0.4 0.0 -1.7 -0.0 0.2 0.0 0.2 0.6 -0.0 0.6 0.5 1.1 1.6 0.7 -1.6 1.0 0.3 1.0
Basal cell carcinoma (self-reported) 0.6 0.7 5.0 0.7 0.8 0.8 0.5 0.9 -0.5 0.0 2.2 1.1 0.8 1.0 0.4 0.5 0.6 0.6 0.8 0.3 0.3 0.9 1.6 0.3 0.7 0.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.8 1.2 1.1 1.1 1.1 1.2 -1.5 0.0 0.5 0.8 1.1 0.3 0.7 1.5 1.4 0.8 0.8 1.7 1.2 1.4 0.3 1.5 1.1 1.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.7 -0.4 -0.2 -0.3 -0.5 -0.3 0.3 0.0 0.4 -0.7 -0.2 0.0 -0.8 -0.9 -0.3 -0.0 0.6 0.2 0.7 0.1 1.3 -0.7 -0.2 0.0
Heart disease (siblings) 1.1 1.4 2.9 1.5 0.9 0.8 0.7 1.1 -1.1 0.0 -0.6 1.6 0.9 0.9 0.8 1.6 1.4 1.2 1.1 1.4 1.5 1.2 -1.2 1.7 0.9 1.2
Alcohol drinker status: Previous 0.4 0.5 5.4 -0.1 0.3 0.2 0.2 0.1 -0.4 0.0 -2.3 -0.9 0.3 -0.1 0.6 0.5 0.0 0.4 0.2 0.9 0.7 -0.4 -1.1 0.9 0.3 0.8
Pack years of smoking 0.2 0.2 0.7 -0.5 -0.7 -0.8 -0.3 -0.6 0.5 0.0 -0.2 -0.5 -0.7 -0.2 -0.3 -0.7 -0.8 -0.5 -0.5 -0.2 0.2 -0.1 -0.2 -0.6 -0.6 -0.4
Impedance of whole body 3.3 16.5 112.4 3.1 1.9 2.1 2.2 2.5 -1.5 0.0 -9.1 2.8 2.0 0.8 3.1 4.9 3.1 1.6 1.0 4.9 2.6 1.8 -10.6 6.4 1.8 4.3
Leg fat mass (left) 1.1 4.5 10.8 -2.3 -2.0 -2.1 -1.4 -2.2 1.8 0.0 2.6 -1.9 -2.0 -1.8 -2.6 -3.2 -2.2 -1.5 -1.1 -2.6 -1.1 -1.4 2.6 -3.3 -1.8 -2.5
Arm predicted mass (left) 6.5 33.0 79.7 -6.1 -5.0 -5.2 -4.1 -5.5 4.7 0.0 6.9 -5.4 -5.1 -4.0 -6.0 -7.6 -6.1 -4.6 -3.8 -7.5 -5.0 -4.3 8.1 -8.9 -4.9 -6.8