Hub : Genes

AC074117.10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.06 0.034 8.0e-04 0.038 NA 0.013 NA 0.023 4.1e-04 NA 2.7e-02 NA 4.8e-03
2 GTEx Adipose Visceral Omentum 0.14 0.066 1.1e-04 0.093 NA 0.044 NA 0.082 1.5e-05 NA 2.3e-03 NA 5.0e-05
3 GTEx Artery Aorta 0.06 0.035 3.1e-03 0.036 NA 0.030 NA 0.032 4.6e-03 NA 8.9e-03 NA 6.8e-03
4 GTEx Artery Coronary 0.13 0.068 1.2e-03 0.170 NA 0.125 NA 0.124 2.4e-06 NA 5.4e-05 NA 6.0e-05
5 GTEx Artery Tibial 0.13 0.044 3.1e-08 0.138 NA 0.098 NA 0.134 6.0e-11 NA 4.0e-08 NA 1.1e-10
6 GTEx Brain Cerebellum 0.13 0.062 2.6e-03 0.085 NA 0.069 NA 0.064 1.7e-03 NA 4.4e-03 NA 6.0e-03
7 GTEx Breast Mammary Tissue (Male) 0.08 0.049 2.3e-02 0.128 NA 0.055 NA 0.002 7.0e-04 NA 2.1e-02 NA 2.8e-01
8 GTEx Breast Mammary Tissue (Female) 0.06 0.046 9.1e-02 0.013 NA -0.010 NA 0.038 1.3e-01 NA 9.9e-01 NA 2.7e-02
9 GTEx Cells Transformed fibroblasts 0.21 0.065 2.7e-10 0.194 NA 0.180 NA 0.061 1.6e-14 NA 1.6e-13 NA 2.3e-05
10 GTEx Colon Sigmoid 0.13 0.049 2.8e-05 0.179 NA 0.112 NA 0.141 6.5e-07 NA 9.4e-05 NA 1.1e-05
11 GTEx Colon Transverse 0.13 0.052 1.5e-05 0.132 NA 0.144 NA 0.138 7.7e-07 NA 2.3e-07 NA 4.2e-07
12 GTEx Esophagus Gastroesophageal Junction 0.12 0.062 2.3e-03 0.126 NA 0.086 NA 0.080 2.6e-05 NA 4.9e-04 NA 7.6e-04
13 GTEx Esophagus Mucosa 0.12 0.044 3.9e-08 0.143 NA 0.128 NA 0.137 8.7e-10 NA 6.6e-09 NA 2.1e-09
14 GTEx Esophagus Muscularis 0.17 0.079 3.0e-05 0.145 NA 0.086 NA 0.061 4.0e-09 NA 6.6e-06 NA 1.5e-04
15 GTEx Lung 0.07 0.029 1.7e-06 0.059 NA 0.046 NA 0.053 2.5e-05 NA 1.9e-04 NA 6.6e-05
16 GTEx Nerve Tibial 0.04 0.023 4.2e-03 0.047 NA 0.019 NA 0.040 2.9e-04 NA 1.6e-02 NA 7.7e-04
17 GTEx Ovary 0.16 0.070 6.3e-04 0.042 NA 0.053 NA 0.028 3.4e-02 NA 2.0e-02 NA 6.9e-02
18 GTEx Pituitary 0.23 0.083 1.4e-05 0.234 NA 0.242 NA 0.289 1.4e-06 NA 9.0e-07 NA 5.6e-08
19 GTEx Prostate 0.14 0.066 2.3e-03 0.012 NA 0.001 NA 0.023 1.6e-01 NA 3.1e-01 NA 8.8e-02
20 GTEx Stomach 0.06 0.037 6.3e-03 0.012 NA 0.003 NA 0.013 8.7e-02 NA 2.3e-01 NA 7.8e-02
21 GTEx Testis 0.14 0.052 3.2e-05 0.075 NA 0.114 NA 0.123 3.1e-04 NA 9.4e-06 NA 4.5e-06
22 GTEx Thyroid 0.17 0.057 5.3e-10 0.135 NA 0.144 NA 0.146 1.7e-10 NA 3.7e-11 NA 2.7e-11
23 GTEx Vagina 0.14 0.067 3.3e-03 0.043 NA 0.065 NA 0.048 3.8e-02 NA 1.4e-02 NA 3.0e-02
24 TCGA Ovarian Tumor 0.03 0.020 3.2e-03 0.018 0.025 0.025 NA 0.037 6.1e-03 0.0015 1.6e-03 NA 1.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Alzheimer’s Disease (in mother) 0.9 1.0 2.1 1.2 1.1 1.2 1.0 1.2 -0.7 0.0 0.3 1.2 1.2 1.2 1.1 0.8 1.3 1.1 0.8 0.7 1.5 1.2 -1.0 1.0 1.1 0.6 0.7
Alzheimer’s Disease (in father) 0.1 0.1 0.7 -0.4 -0.3 -0.4 -0.2 -0.4 0.1 0.0 -0.2 -0.5 -0.3 -0.2 -0.8 -0.6 -0.5 -0.1 -0.3 0.1 0.2 -0.2 0.4 -0.3 -0.2 -0.3 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.2 1.1 0.1 0.5 0.8 0.3 0.5 0.2 0.0 -0.2 0.1 0.6 0.5 -0.1 -0.2 0.2 0.0 -0.0 0.0 0.6 0.2 -1.0 0.2 0.4 -0.3 -0.0
Crohns Disease (2017) 6.5 14.2 33.9 -4.3 -4.1 -4.1 -2.2 -4.0 4.0 0.0 2.4 -3.6 -4.1 -3.3 -4.3 -5.0 -4.1 -3.6 -3.2 -4.8 -3.4 -2.9 2.4 -5.8 -3.9 -4.3 -2.8
Irritable Bowel Disease (IBD) 6.0 14.3 27.7 -4.2 -4.3 -4.4 -2.6 -4.3 4.1 0.0 0.8 -3.7 -4.3 -3.5 -3.7 -4.7 -4.1 -3.9 -3.8 -4.7 -3.7 -3.4 0.4 -5.3 -4.2 -4.5 -2.4
Ulcerative Colitis (UC) 2.8 5.4 8.2 -2.3 -2.7 -2.8 -1.9 -2.7 2.5 0.0 -0.5 -2.2 -2.8 -2.1 -1.8 -2.5 -2.5 -2.6 -2.5 -2.8 -2.6 -2.4 -1.2 -2.7 -2.7 -2.9 -1.1
Major Depression (MDD) 3.3 4.1 10.0 -1.7 -2.1 -2.2 -2.1 -2.0 2.1 0.0 -3.2 -2.1 -2.1 -2.0 -2.5 -1.8 -1.6 -1.8 -2.0 -1.3 -1.0 -1.9 -2.8 -1.6 -2.0 -1.5 -2.7
Reaction Time 0.8 1.5 4.8 1.6 1.5 1.5 0.1 1.2 -1.5 0.0 -0.2 0.5 1.5 1.9 2.2 1.2 1.4 1.2 1.2 1.0 0.7 0.3 0.5 1.4 1.5 0.9 1.5
Verbal and Numeric Reasoning (VNR) 0.8 2.0 6.5 -1.7 -1.1 -0.9 -0.5 -1.1 1.7 0.0 1.7 -0.9 -1.1 -1.1 -1.0 -1.3 -1.6 -1.4 -1.3 -2.5 -2.4 -1.4 0.9 -1.9 -1.3 -1.7 0.3
Breast Cancer 0.2 0.4 3.8 0.3 0.0 -0.1 0.7 0.1 0.1 0.0 -0.8 0.5 0.0 0.2 0.9 0.4 0.4 0.4 -0.7 0.4 0.4 0.3 -2.0 0.8 0.2 0.1 0.9
Ovarian Cancer 2.8 3.7 5.8 2.0 2.0 2.0 1.4 2.1 -1.9 0.0 2.4 2.4 2.0 1.9 2.2 2.1 2.2 2.0 1.8 1.4 1.4 2.0 2.2 1.5 2.0 1.4 2.3
Prostate Cancer 0.7 1.0 8.7 -0.4 -0.8 -0.7 -0.8 -0.5 0.7 0.0 -2.4 -0.1 -0.8 -1.7 -0.2 -0.3 -0.3 -0.9 -0.8 0.4 -0.2 -0.1 -3.0 0.4 -0.9 -0.2 -1.2
Age at First Birth 0.6 0.9 5.9 0.7 0.7 0.8 0.6 0.7 -0.8 0.0 -2.4 0.3 0.8 1.0 0.7 0.9 0.5 0.7 0.5 1.0 0.5 0.2 -1.4 1.0 0.7 1.0 2.0
Bipolar Disorder 3.8 3.8 7.7 2.2 2.0 1.9 0.1 1.9 -2.0 0.0 -2.2 1.8 1.9 1.4 0.9 2.5 2.5 2.1 1.3 2.6 2.7 1.5 -1.9 2.8 2.0 2.4 0.4
Body Mass Index (BMI) (2010) 1.4 2.0 4.5 -1.7 -1.3 -1.3 -0.6 -1.4 1.4 0.0 -0.9 -1.6 -1.3 -1.4 -1.5 -1.5 -1.8 -1.5 -1.5 -1.4 -1.4 -1.5 -0.1 -1.7 -1.4 -1.6 -2.1
Coronary Artery Disease (CAD) 0.7 0.8 4.5 0.7 1.0 1.1 0.5 0.8 -1.0 0.0 -2.1 0.1 1.1 0.9 0.9 1.2 0.6 0.6 0.4 0.9 0.6 0.1 -1.0 1.1 0.9 1.2 0.0
Crohns Disease (2012) 2.2 3.5 10.0 1.9 1.9 1.9 1.6 1.9 -1.9 0.0 -1.6 1.3 1.9 1.2 2.6 2.8 1.8 1.8 1.5 2.2 1.5 1.2 -1.8 3.2 1.8 2.4 0.8
Mean Putamen Volume 0.2 0.2 2.6 0.1 0.1 0.1 0.0 0.1 0.1 0.0 -1.3 0.0 0.1 -0.0 0.5 0.5 0.2 -0.0 -0.7 0.2 -0.0 -0.4 -1.6 0.4 0.1 0.0 0.2
Fasting Glucose 27.3 32.8 56.0 -5.7 -5.7 -5.4 -5.2 -6.2 6.0 0.0 4.3 -6.2 -5.7 -4.6 -7.1 -6.7 -6.7 -6.5 -3.9 -7.4 -7.5 -5.9 5.5 -6.0 -6.1 -5.5 1.5
HbA1C 0.3 0.4 1.1 -0.7 -0.4 -0.4 0.6 -0.3 0.4 0.0 1.0 -0.7 -0.3 -0.6 -0.5 0.0 -0.4 -0.2 -0.2 -0.9 -0.9 -0.3 1.0 -1.0 -0.3 -0.0 -1.0
HDL Cholesterol 1.1 1.8 5.2 -1.3 -1.4 -1.6 -0.3 -1.3 1.3 0.0 0.4 -1.6 -1.4 -1.1 -1.0 -1.1 -1.5 -1.0 -1.7 -1.6 -1.2 -1.1 0.6 -1.8 -1.3 -1.5 -2.3
LDL Cholesterol 1.3 2.0 13.5 1.5 0.5 0.5 0.2 0.7 -0.5 0.0 -1.8 1.8 0.5 0.9 2.1 1.6 1.4 0.7 0.4 1.5 0.9 0.8 -3.7 2.1 0.5 1.4 2.0
Lupus 3.6 5.5 8.8 2.5 2.5 2.4 2.1 2.4 -2.8 0.0 0.3 2.2 2.5 2.2 1.9 2.4 2.5 2.4 2.8 3.0 2.6 2.5 0.8 2.7 2.5 2.8 2.6
Neuroticism 0.1 0.2 0.7 -0.1 -0.3 -0.3 0.6 0.1 0.4 0.0 0.8 0.4 -0.4 -0.5 -0.2 0.3 -0.2 -0.4 -0.5 -0.5 -0.0 0.5 -0.5 -0.4 -0.4 0.1 -0.8
Primary Biliary Cirrhosis 3.8 5.4 10.8 2.5 2.4 2.5 1.3 2.4 -2.5 0.0 -0.8 2.4 2.5 1.7 2.1 2.2 2.8 2.5 2.8 3.3 3.3 2.2 -0.8 3.0 2.5 3.1 0.7
Rheumatoid Arthritis 0.2 0.3 1.3 -0.5 -0.4 -0.3 0.1 -0.4 0.5 0.0 -0.4 -1.0 -0.4 -0.1 0.0 -0.6 -0.8 -0.7 -0.5 -0.8 -1.1 -0.8 0.3 -0.6 -0.5 -0.8 -0.3
Schizophrenia 3.2 7.2 19.1 -2.2 -2.7 -2.8 -2.8 -2.8 2.6 0.0 -4.3 -2.6 -2.7 -2.6 -2.7 -2.2 -2.2 -2.3 -3.3 -1.6 -1.2 -2.8 -4.4 -1.5 -2.5 -2.1 -3.9
Triglycerides 114.8 188.3 392.0 15.2 13.0 13.0 9.2 13.9 -12.9 0.0 -9.3 15.2 13.1 11.3 16.0 17.5 15.2 13.3 10.3 17.4 15.1 13.1 -12.9 19.8 13.2 16.7 9.9
Type 2 Diabetes (T2D) 0.8 0.9 2.8 -1.3 -0.5 -0.5 -0.8 -0.9 0.8 0.0 -0.3 -1.4 -0.6 -0.7 -1.2 -1.7 -1.2 -0.7 0.1 -1.1 -0.5 -1.2 1.2 -1.6 -0.4 -0.7 -1.0
Ulcerative Colitis 5.1 7.5 12.8 2.7 3.0 3.1 2.4 3.0 -2.9 0.0 0.2 3.0 3.1 2.3 1.9 2.8 2.9 2.9 3.5 3.6 3.3 2.9 0.8 3.3 3.0 3.6 1.2
Blood Eosinophil Count 1.0 7.8 34.5 2.4 2.6 2.5 1.5 2.7 -2.7 0.0 5.9 2.5 2.6 3.1 2.6 2.1 2.5 2.9 2.4 0.9 2.1 2.6 5.8 0.5 2.7 1.6 2.7
Blood Platelet Count 15.5 180.3 368.6 14.2 13.2 12.7 12.0 13.9 -13.6 0.0 -7.3 13.5 13.2 10.8 14.3 17.1 14.2 14.1 11.4 17.4 14.9 13.6 -9.4 19.2 13.5 17.0 8.7
Blood Red Count 0.9 8.7 84.8 0.2 1.1 0.9 0.1 0.9 -1.0 0.0 9.2 1.4 1.1 2.0 -0.4 -1.4 0.4 1.3 2.0 -1.0 0.9 2.2 9.1 -2.8 1.2 -0.3 2.4
Blood White Count 14.9 109.0 196.0 11.5 10.6 10.4 7.4 11.1 -10.7 0.0 -2.9 11.8 10.6 9.8 11.2 12.6 11.4 10.9 9.1 12.9 11.6 10.7 -5.3 14.0 10.7 12.2 9.8
Heel T-Score 0.4 3.3 6.3 -2.2 -1.5 -1.4 -1.3 -1.7 1.8 0.0 -1.8 -2.4 -1.4 -2.2 -2.3 -2.3 -1.7 -1.5 -1.6 -1.9 -1.3 -2.3 0.2 -2.3 -1.5 -1.9 -2.5
BMI 0.7 4.3 26.9 -1.8 -1.1 -1.2 -1.7 -1.5 0.9 0.0 4.2 -1.6 -1.2 -0.7 -1.8 -3.1 -1.7 -1.0 -0.5 -2.1 -0.8 -1.0 5.2 -3.1 -1.1 -2.1 -2.0
Height 3.5 69.4 130.0 -9.5 -8.5 -8.5 -5.9 -9.0 8.3 0.0 2.0 -9.6 -8.6 -7.5 -9.1 -10.3 -9.7 -8.4 -7.0 -10.2 -8.5 -8.3 4.0 -11.4 -8.5 -9.7 -7.9
Waist Hip Ratio (WHR) 0.6 2.6 19.9 -0.5 -1.8 -2.0 -1.4 -1.6 1.5 0.0 -1.7 0.6 -1.9 -1.9 -1.9 -0.8 -0.4 -1.1 -0.6 -0.2 -0.0 -0.3 -4.5 -0.2 -1.6 -0.7 -2.8
Systolic Blood Pressure 3.5 17.5 28.2 3.4 4.6 4.7 5.1 4.7 -4.2 0.0 1.6 5.2 4.7 3.1 3.4 3.7 3.7 4.5 5.2 4.9 5.2 5.2 0.5 4.5 4.6 5.3 2.4
Smoking Status 0.3 0.7 7.4 0.2 0.3 0.5 -0.2 0.2 -0.4 0.0 -2.7 -0.3 0.3 -0.0 0.2 0.1 0.1 0.1 0.5 0.9 0.6 -0.3 -2.2 1.0 0.3 0.5 -0.1
Allergy or Eczema 5.8 15.2 22.7 4.2 4.2 4.3 3.5 4.3 -4.2 0.0 -0.3 3.6 4.2 3.8 4.8 4.3 4.1 3.9 4.2 4.6 3.8 3.9 0.6 4.7 4.1 4.0 4.5
Cardiovascular Disease 6.8 22.6 46.4 5.1 4.7 4.7 3.5 4.9 -5.0 0.0 -0.6 5.7 4.7 3.6 4.2 5.5 5.0 4.7 5.6 6.7 5.5 5.5 -1.4 6.8 4.7 6.2 2.3
Hypothyroidism (self reported) 0.3 0.7 4.9 0.5 0.5 0.5 0.6 0.4 -0.6 0.0 0.7 1.2 0.4 0.8 0.4 0.3 0.4 0.5 1.5 0.9 0.6 0.8 0.5 0.7 0.5 1.0 2.2
Respiratory disease 0.1 0.2 0.9 0.6 0.1 0.1 -0.9 0.1 -0.1 0.0 -0.9 0.1 0.2 0.3 0.3 -0.0 0.6 0.2 0.4 0.7 0.7 0.1 -0.6 0.4 0.1 0.4 -0.1
Type 2 Diabetes (T2D) 13.3 25.0 46.2 -5.8 -5.2 -5.2 -3.6 -5.4 4.8 0.0 2.1 -5.9 -5.2 -5.1 -5.7 -6.2 -5.7 -5.1 -4.0 -5.8 -4.9 -4.6 2.7 -6.8 -5.1 -5.3 -4.8
Lung FEV1/FVC ratio 0.1 0.5 4.4 0.2 -0.3 -0.3 -0.4 -0.1 0.2 0.0 2.1 1.5 -0.4 -0.1 1.1 0.6 0.1 -0.5 -0.5 -0.5 -0.9 0.5 -0.1 0.3 -0.3 -0.6 1.0
Lung FVC 0.6 3.0 7.2 1.5 1.4 1.4 1.4 1.4 -1.5 0.0 -2.5 1.8 1.4 1.2 1.1 1.9 1.5 1.7 1.1 2.3 1.9 1.1 -2.7 2.6 1.5 1.9 2.3
Neuroticism 2.3 5.5 9.9 2.8 2.6 2.7 2.0 3.0 -2.4 0.0 2.1 2.5 2.6 2.5 1.8 2.7 2.7 2.2 2.5 2.1 2.0 3.1 2.0 2.0 2.5 2.5 1.0
Chronotype (morning person) 0.3 0.6 5.4 0.4 -0.3 -0.3 -1.1 -0.0 0.2 0.0 2.3 1.2 -0.3 0.7 0.5 0.2 0.2 -0.2 -0.8 -0.7 -0.6 0.6 0.4 -0.5 -0.3 -0.5 1.4
Hair Pigment 1.8 55.3 83.4 8.4 7.8 7.8 5.8 8.5 -8.1 0.0 3.6 9.1 7.8 7.1 7.4 8.6 8.7 7.7 7.8 8.1 7.5 8.6 3.2 8.1 7.8 7.9 6.3
Tanning 1.4 19.2 40.6 -5.1 -4.1 -4.1 -2.1 -4.5 4.3 0.0 1.9 -5.1 -4.1 -3.4 -4.8 -5.5 -5.2 -4.0 -4.6 -5.6 -4.1 -4.7 3.1 -6.4 -4.1 -5.2 -4.0
Hand grip strength (left) 2.1 5.6 9.4 2.4 2.6 2.4 2.8 2.7 -2.6 0.0 -0.5 2.0 2.5 2.0 2.7 2.6 2.5 2.6 2.1 3.0 2.6 2.6 -1.0 3.1 2.6 2.8 1.1
Number of treatments/medications taken 7.6 13.7 23.8 -3.6 -3.9 -3.9 -4.1 -4.2 4.0 0.0 -0.8 -4.0 -3.9 -2.5 -3.0 -4.3 -3.8 -3.9 -4.2 -4.5 -4.2 -4.6 -0.2 -4.4 -3.9 -4.9 -2.0
Average weekly spirits intake 0.4 0.5 3.2 -0.0 -0.3 -0.3 -0.8 -0.5 0.1 0.0 1.4 -0.0 -0.4 0.3 -0.3 -0.8 -0.3 -0.5 -0.1 -0.5 -0.4 -0.3 1.8 -0.7 -0.3 -1.1 1.5
Sensitivity / hurt feelings 0.3 0.5 3.3 -0.5 -0.4 -0.4 -0.4 -0.7 0.6 0.0 -1.8 -0.4 -0.5 0.0 0.0 -0.6 -0.5 -0.4 -1.0 -0.5 -0.3 -1.1 -1.3 -0.1 -0.4 -1.1 0.9
Frequency of depressed mood in last 2 weeks 1.5 2.1 4.5 -1.9 -1.3 -1.3 -0.9 -1.5 1.5 0.0 0.7 -1.8 -1.3 -1.2 -1.4 -2.0 -1.7 -1.2 -1.6 -2.0 -1.3 -1.8 0.6 -2.1 -1.3 -1.8 -0.9
Hearing difficulty/problems: Yes 1.0 1.5 3.1 -1.5 -1.3 -1.2 0.1 -1.2 1.1 0.0 0.3 -1.6 -1.3 -1.5 0.5 -0.6 -1.6 -1.5 -1.8 -1.7 -1.7 -1.3 -0.5 -1.3 -1.4 -1.2 -0.9
Relative age of first facial hair 2.9 6.0 14.0 -2.9 -2.1 -2.2 -1.0 -2.3 1.9 0.0 3.5 -2.1 -2.1 -1.9 -3.3 -3.3 -2.9 -2.1 -0.3 -3.0 -2.5 -1.6 3.7 -3.7 -2.1 -2.1 -1.4
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 5.2 -1.7 -1.5 -1.5 -0.7 -1.7 1.4 0.0 1.1 -1.4 -1.6 -1.2 -1.4 -1.4 -1.9 -1.7 -1.3 -1.9 -2.3 -1.7 1.6 -1.6 -1.5 -1.8 -0.7
Ever used hormone-replacement therapy (HRT) 8.2 10.4 15.5 3.5 3.7 3.8 2.1 3.5 -3.8 0.0 1.3 2.9 3.7 3.9 3.9 3.4 3.3 3.4 3.4 3.2 2.4 2.7 2.3 3.4 3.6 3.2 3.8
Ever had hysterectomy (womb removed) 0.7 0.8 5.5 -0.4 -0.5 -0.5 -0.7 -0.5 0.5 0.0 1.7 -0.6 -0.6 -0.2 -0.4 -0.4 -0.6 -0.7 -0.7 -1.3 -1.3 -0.6 2.4 -1.2 -0.6 -1.1 -0.3
Systolic blood pressure, automated reading 2.6 7.8 16.8 -2.2 -3.1 -3.1 -4.1 -3.1 2.7 0.0 -1.6 -3.4 -3.1 -2.4 -1.8 -2.2 -2.3 -3.2 -3.5 -2.8 -3.6 -3.4 -1.0 -2.5 -3.1 -3.4 -1.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 4.4 0.7 0.4 0.4 0.4 0.4 -0.4 0.0 -2.1 0.6 0.4 0.3 0.8 1.1 0.6 0.5 -0.3 1.0 0.4 0.3 -2.1 1.5 0.4 0.4 0.6
Angina 2.1 2.7 6.3 -2.2 -1.6 -1.7 -0.5 -1.9 1.5 0.0 -0.8 -2.2 -1.6 -1.0 -0.5 -2.1 -2.5 -1.3 -1.5 -2.2 -2.0 -2.2 1.1 -2.3 -1.4 -1.7 0.2
Medication for hormone replacement therapy 0.6 0.7 4.1 0.8 0.6 0.9 -1.1 0.6 -0.6 0.0 1.1 -0.1 0.7 1.2 1.2 0.3 0.7 -0.0 0.5 -0.3 -0.8 -0.1 1.6 -0.2 0.5 -0.4 2.0
Vitamin and mineral supplements 4.4 6.0 10.7 2.3 2.6 2.4 3.3 2.7 -2.6 0.0 -0.1 2.4 2.5 1.9 2.0 2.6 2.2 2.8 2.8 3.1 2.9 3.0 -0.0 3.0 2.7 3.2 0.6
Supplements: Zinc 0.2 0.2 1.0 0.8 -0.1 -0.1 -1.0 0.1 -0.2 0.0 0.2 0.2 -0.1 -0.0 0.4 0.8 0.9 0.0 -0.3 0.3 -0.2 0.2 -0.3 0.4 -0.0 0.2 0.4
Medication: Co-codamol 0.3 0.4 3.9 -0.2 0.2 0.4 -0.2 0.0 0.2 0.0 1.4 -0.1 0.3 0.4 -0.7 -0.7 -0.0 -0.3 -0.2 -0.3 -0.1 -0.2 2.0 -0.9 0.1 -0.1 0.1
Medication: Metformin 8.1 11.4 20.7 3.9 3.4 3.5 2.1 3.5 -3.2 0.0 -1.5 4.0 3.4 3.7 3.7 3.9 3.7 3.4 3.3 4.1 3.2 3.3 -1.9 4.5 3.4 3.6 3.6
Diabetes (father) 4.7 5.8 12.6 2.8 2.2 2.2 1.3 2.4 -2.3 0.0 -1.6 2.7 2.2 1.6 2.0 3.0 3.0 2.2 2.1 3.5 2.6 2.6 -2.2 3.6 2.2 2.9 1.5
Diabetes (mother) 2.1 2.7 9.5 1.4 1.0 0.8 0.6 1.1 -1.2 0.0 -2.5 1.7 0.9 0.7 1.0 1.9 1.4 1.4 0.9 2.4 2.0 1.5 -3.1 2.9 1.2 2.2 1.6
Severe depression (siblings) 0.1 0.1 0.5 0.2 0.0 0.2 -0.2 0.2 0.0 0.0 0.2 0.7 0.1 0.0 -0.4 0.1 0.2 -0.4 0.1 0.3 -0.2 0.2 -0.7 0.3 -0.0 -0.0 0.5
Pack years adult smoking proportion 0.0 0.1 0.5 -0.1 0.3 0.4 0.1 0.1 0.1 0.0 -0.3 -0.1 0.3 -0.2 -0.3 0.1 0.3 -0.0 -0.0 -0.4 -0.7 -0.5 -0.1 -0.1 0.1 -0.2 0.2
Impedance of leg (right) 1.8 9.1 88.8 -1.8 -0.6 -0.7 -1.0 -1.1 0.4 0.0 8.1 -1.6 -0.6 -0.1 -1.8 -3.2 -1.7 -0.5 0.2 -3.2 -1.3 -0.8 9.4 -4.3 -0.5 -2.7 -0.5
Leg fat-free mass (left) 4.7 25.3 58.7 5.3 4.4 4.5 3.7 4.9 -4.0 0.0 -6.5 4.9 4.4 3.5 5.2 6.7 5.3 4.0 3.1 6.5 4.2 3.9 -7.6 7.7 4.2 5.9 4.0
Trunk fat percentage 0.2 1.0 11.6 0.7 0.6 0.8 -0.4 0.7 -0.6 0.0 1.2 0.3 0.6 1.4 0.9 0.6 0.5 0.2 0.3 0.1 -0.5 0.3 1.8 -0.1 0.5 0.1 3.4
Hand grip strength (right) 2.0 5.6 10.5 2.6 2.5 2.4 2.2 2.6 -2.5 0.0 -1.3 2.1 2.5 2.1 2.6 2.8 2.7 2.4 2.1 3.1 2.4 2.3 -1.3 3.2 2.5 2.9 1.0
Townsend deprivation index at recruitment 1.5 2.1 7.0 0.9 1.8 1.8 2.6 1.7 -1.4 0.0 0.9 1.4 1.8 1.1 1.0 1.3 1.1 1.6 1.7 1.4 1.2 1.5 0.9 1.3 1.7 1.7 0.9
Current tobacco smoking 0.5 0.7 1.9 -1.4 -0.6 -0.6 0.6 -0.7 0.8 0.0 0.5 -1.3 -0.6 -0.9 -0.9 -1.1 -1.2 -0.7 -0.6 -1.0 -0.9 -0.8 1.0 -1.3 -0.7 -0.7 -0.4
Average weekly fortified wine intake 0.3 0.3 0.6 0.5 0.6 0.7 0.5 0.6 -0.7 0.0 -0.1 0.8 0.6 0.1 0.5 0.7 0.6 0.6 0.6 0.6 0.5 0.4 -0.1 0.7 0.6 0.6 0.3
Maternal smoking around birth 0.3 0.5 2.0 0.6 0.5 0.5 1.0 0.7 -0.3 0.0 1.4 0.6 0.5 0.6 1.2 0.8 0.4 0.1 0.2 -0.4 -0.7 0.8 0.8 0.1 0.3 -0.1 1.1
Fed-up feelings 1.1 2.0 4.0 -1.9 -1.3 -1.3 0.2 -1.5 1.3 0.0 -1.9 -1.9 -1.3 -1.3 -1.1 -1.9 -2.0 -1.3 -1.2 -1.2 -1.3 -1.9 -1.6 -1.2 -1.3 -1.5 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.4 -0.8 -0.5 -0.6 -1.0 -0.8 0.7 0.0 0.8 -0.6 -0.5 -0.3 -0.8 -1.1 -0.7 -0.5 -0.6 -1.2 -0.8 -0.9 0.1 -1.0 -0.5 -1.1 -0.2
Relative age voice broke 2.7 4.2 8.4 -2.4 -2.3 -2.4 -1.3 -2.4 2.2 0.0 1.2 -2.0 -2.4 -1.9 -2.5 -2.7 -2.6 -2.0 -1.1 -2.4 -2.2 -1.5 0.6 -2.9 -2.3 -1.7 -1.8
Taking other prescription medications 2.9 4.5 8.7 -2.1 -2.5 -2.5 -1.6 -2.4 2.4 0.0 -0.1 -1.6 -2.5 -1.8 -2.0 -2.1 -2.5 -2.3 -2.4 -2.5 -3.0 -2.2 -0.7 -2.0 -2.4 -2.7 -1.3
Age when periods started (menarche) 2.6 6.4 21.9 1.6 3.1 3.1 2.8 2.6 -2.6 0.0 2.8 1.4 3.1 2.9 1.8 1.4 1.7 2.7 3.8 1.6 2.1 1.8 4.7 1.2 3.0 2.5 1.8
Bilateral oophorectomy (both ovaries removed) 4.0 4.6 8.1 -2.0 -2.2 -2.1 -2.1 -2.4 2.3 0.0 -0.7 -2.3 -2.2 -1.8 -1.5 -2.0 -2.1 -2.4 -2.7 -2.7 -2.8 -2.8 -0.8 -2.2 -2.3 -2.8 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 5.2 2.1 1.4 1.3 1.3 1.7 -1.5 0.0 1.1 2.3 1.4 1.5 1.7 2.3 1.9 1.4 1.5 2.0 1.2 2.2 0.2 2.0 1.4 2.1 0.9
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 3.5 0.6 0.5 0.5 1.4 0.5 -0.7 0.0 -0.2 0.5 0.5 1.1 1.2 0.7 0.4 0.8 0.4 0.8 0.5 0.7 0.1 0.8 0.6 0.8 1.9
Qualifications: CSEs or equivalent 0.1 0.1 0.7 0.6 0.3 0.3 0.1 0.4 0.1 0.0 0.9 0.3 0.3 0.6 0.0 -0.0 0.7 0.3 0.0 -0.4 0.3 0.2 -0.0 -0.3 0.3 -0.2 0.1
Serious illness, injury or assault to yourself 1.3 1.6 3.2 -1.5 -1.3 -1.2 -0.8 -1.4 1.5 0.0 0.4 -1.1 -1.2 -0.8 -0.9 -1.6 -1.6 -1.3 -1.7 -1.8 -1.3 -1.6 0.2 -1.5 -1.3 -1.7 -0.7
High blood pressure 2.1 6.1 13.2 -2.4 -2.6 -2.6 -2.3 -2.6 2.5 0.0 -0.5 -2.8 -2.6 -1.7 -1.0 -2.1 -2.4 -2.5 -3.6 -3.5 -3.2 -3.2 -0.6 -3.0 -2.6 -3.4 -0.1
Hayfever, allergic rhinitis or eczema 7.2 15.4 22.5 -4.3 -4.3 -4.3 -3.3 -4.2 4.2 0.0 0.1 -3.7 -4.3 -4.2 -4.7 -4.2 -4.0 -4.0 -4.3 -4.5 -3.8 -3.8 -1.3 -4.5 -4.2 -4.0 -4.7
Multivitamins +/- minerals 2.9 3.7 6.7 -2.1 -2.1 -2.0 -2.3 -2.3 2.0 0.0 -0.3 -2.2 -2.0 -1.4 -1.5 -2.5 -2.0 -2.0 -2.1 -2.2 -1.7 -2.4 -0.2 -2.3 -2.0 -2.6 -0.3
Stomach or abdominal pain in last month 5.4 6.7 11.3 -3.3 -2.6 -2.4 -1.6 -3.0 2.8 0.0 0.0 -2.8 -2.5 -2.3 -3.1 -3.4 -3.3 -2.8 -2.5 -3.0 -2.7 -3.2 -0.5 -2.8 -2.7 -3.2 -0.5
Supplements: Glucosamine 0.6 0.8 1.6 0.9 1.1 1.2 1.3 1.1 -1.0 0.0 0.5 0.8 1.1 1.0 0.9 0.7 0.9 0.8 1.1 0.7 0.5 1.0 0.5 0.7 1.0 0.9 0.1
Diverticular disease/diverticulitis (self-reported) 5.6 6.6 11.0 -2.3 -3.1 -3.1 -2.1 -2.9 2.9 0.0 -0.8 -2.3 -3.1 -3.0 -2.7 -2.4 -2.4 -2.9 -2.5 -2.6 -2.9 -2.4 -1.8 -2.3 -3.1 -2.4 -3.3
Medication: Atenolol 0.2 0.3 2.3 -0.7 -0.2 -0.2 0.0 -0.4 0.3 0.0 -1.5 -0.9 -0.2 -0.3 -0.0 -0.6 -0.7 -0.2 -0.4 -0.3 -0.1 -0.7 -1.0 -0.4 -0.2 -0.0 -0.4
Medication: Levothyroxine sodium 0.4 0.7 4.3 -0.4 -0.6 -0.6 -1.1 -0.6 0.7 0.0 0.2 -0.5 -0.6 -0.7 -0.4 -0.3 -0.3 -0.7 -1.3 -1.1 -1.0 -0.8 -0.6 -0.8 -0.7 -1.0 -2.1
Sitting height 4.3 30.7 63.8 6.2 5.6 5.5 4.7 5.9 -5.5 0.0 -4.1 5.7 5.6 4.5 5.4 7.0 6.2 5.5 4.3 7.2 5.7 5.0 -4.9 8.0 5.6 6.5 3.7
Chronic bronchitis/emphysema (father) 0.3 0.4 2.0 -0.5 0.2 0.3 -0.4 0.0 0.1 0.0 0.9 -0.4 0.2 0.4 0.2 -0.4 -0.5 -0.2 -0.3 -1.0 -1.0 -0.5 1.4 -0.9 0.0 -0.5 1.1
High blood pressure (mother) 3.5 4.9 8.6 -1.9 -2.6 -2.8 -2.9 -2.9 2.4 0.0 -0.9 -2.5 -2.7 -1.9 -1.9 -2.5 -2.0 -2.2 -2.1 -2.2 -1.8 -2.7 -1.4 -2.2 -2.5 -2.1 -1.6
Body mass index (BMI) 0.5 2.3 16.0 1.2 0.7 0.9 0.3 0.9 -0.5 0.0 -3.8 0.8 0.7 0.6 1.2 2.0 1.0 0.1 0.2 1.7 0.2 0.3 -4.0 2.3 0.5 1.3 1.7
Impedance of leg (left) 1.9 9.5 82.8 -2.3 -1.1 -1.2 -1.4 -1.6 0.9 0.0 7.4 -2.2 -1.1 -0.4 -2.2 -3.7 -2.1 -0.8 -0.2 -3.5 -1.5 -1.3 9.1 -4.6 -1.0 -2.9 -0.5
Leg predicted mass (left) 4.6 24.9 57.9 5.3 4.3 4.5 3.7 4.9 -4.0 0.0 -6.4 4.9 4.4 3.5 5.1 6.7 5.2 3.9 3.0 6.5 4.2 3.9 -7.6 7.6 4.2 5.9 4.0
Trunk fat mass 1.2 5.4 18.0 2.6 2.4 2.5 1.4 2.5 -2.2 0.0 -1.2 2.1 2.4 2.5 2.8 3.1 2.4 1.9 1.5 2.6 1.3 1.8 -1.1 3.0 2.2 2.4 4.2
Waist circumference 1.4 5.5 14.4 2.5 2.2 2.4 1.2 2.3 -2.1 0.0 -2.5 1.8 2.2 2.4 3.0 3.1 2.3 1.7 1.4 2.9 1.3 1.4 -2.1 3.4 2.1 2.6 3.8
Number of incorrect matches in round 0.9 1.6 11.2 1.2 0.7 0.7 -0.1 0.9 -0.6 0.0 3.3 2.1 0.7 1.6 0.7 0.4 1.2 0.9 0.5 0.2 1.2 1.5 2.0 -0.2 0.7 0.1 2.1
Past tobacco smoking 0.2 0.4 4.5 -0.4 0.1 0.2 1.3 -0.0 -0.1 0.0 -2.1 -0.7 0.1 -0.2 -0.1 -0.5 -0.4 0.0 0.4 0.5 0.6 -0.3 -1.3 0.2 0.1 0.3 -0.2
Alcohol usually taken with meals 2.0 3.3 6.7 -1.6 -2.1 -2.0 -2.0 -1.9 1.9 0.0 0.6 -1.4 -2.1 -1.7 -1.6 -1.7 -1.5 -2.1 -2.0 -2.3 -2.0 -1.7 0.5 -2.6 -2.1 -2.2 -1.5
Nervous feelings 0.1 0.2 1.0 -0.6 -0.2 -0.4 0.6 -0.5 0.0 0.0 -1.0 -0.2 -0.2 -0.2 0.6 -0.3 -0.5 0.4 -0.5 -0.1 0.3 -0.4 -1.0 0.1 -0.0 0.0 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.1 -1.4 -1.1 -1.1 -0.9 -1.2 1.2 0.0 -0.3 -1.7 -1.1 -0.8 -0.7 -1.4 -1.4 -1.1 -1.6 -1.8 -1.4 -1.6 0.2 -1.8 -1.1 -1.7 -0.6
Hearing difficulty/problems with background noise 0.6 1.0 3.6 -0.3 -1.2 -1.3 -1.1 -1.0 0.8 0.0 1.7 -0.0 -1.2 -0.6 0.6 0.2 -0.6 -1.1 -1.9 -1.2 -1.5 -0.5 0.0 -0.8 -1.2 -1.1 0.5
Hair/balding pattern: Pattern 2 0.6 0.8 2.6 -1.2 -0.9 -0.8 -0.3 -1.2 0.8 0.0 -0.3 -0.6 -0.9 -0.7 -1.6 -1.5 -1.3 -0.9 -0.4 -0.5 -0.6 -1.1 -0.1 -0.5 -0.9 -1.3 -0.2
Had menopause 24.3 30.5 40.3 5.9 5.9 5.7 4.4 5.9 -6.3 0.0 3.6 5.7 5.8 5.6 6.3 6.3 5.7 5.9 6.0 5.6 4.9 5.8 4.1 5.8 5.9 6.2 5.4
Had other major operations 0.3 0.4 4.2 0.3 -0.2 -0.1 -2.1 -0.4 0.4 0.0 -1.1 -0.2 -0.3 -0.1 -0.0 0.1 0.4 -0.6 -0.7 -0.6 -0.6 -1.1 -0.3 -0.4 -0.4 -0.4 0.2
Forced vital capacity (FVC) 0.5 1.8 2.8 1.3 1.6 1.7 1.6 1.6 -1.5 0.0 -0.2 0.8 1.6 1.5 1.3 1.2 1.2 1.4 1.3 1.7 1.4 1.1 -0.1 1.6 1.6 1.4 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.3 2.1 1.2 1.2 0.6 1.5 -1.4 0.0 1.3 2.0 1.2 1.7 1.6 2.0 1.8 1.1 0.9 1.5 0.7 1.7 0.5 1.6 1.2 1.4 0.8
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 2.2 -0.2 0.4 0.5 -0.2 0.1 -0.4 0.0 0.2 0.0 0.4 0.6 -0.6 -0.4 -0.2 0.1 0.4 -0.2 -0.4 -0.5 1.5 -0.3 0.4 -0.3 1.1
Qualifications: None of the above 0.4 0.9 4.9 0.5 0.7 0.6 0.2 0.5 -0.7 0.0 2.2 0.8 0.7 1.1 0.7 0.7 0.6 0.9 1.0 0.2 0.0 0.5 2.1 0.4 0.7 0.5 2.0
Financial difficulties in last 2 years 0.1 0.2 1.9 0.0 0.2 0.1 0.1 -0.0 -0.4 0.0 0.6 -0.2 0.2 0.7 -0.5 -0.2 -0.1 0.3 -0.2 0.2 0.4 -0.1 1.4 -0.2 0.2 -0.1 0.7
Mouth/teeth dental problems 0.1 0.1 0.7 -0.1 0.2 0.2 0.1 0.4 -0.2 0.0 0.8 0.5 0.2 0.1 -0.3 -0.2 -0.1 0.1 0.2 -0.0 0.6 0.9 0.2 -0.3 0.2 -0.2 0.9
Heart attack 1.0 1.2 2.6 -1.2 -1.2 -1.2 -1.2 -1.3 1.5 0.0 -0.7 -0.9 -1.2 -0.3 -0.6 -1.5 -1.4 -0.8 -0.9 -1.6 -1.2 -1.4 -0.5 -1.4 -1.1 -1.1 0.3
Allergy 2.9 6.5 10.6 2.8 2.7 2.6 1.8 2.6 -2.6 0.0 0.0 2.3 2.7 2.9 2.9 2.4 2.6 2.7 3.3 3.1 2.8 2.7 1.2 2.8 2.6 2.8 3.1
Pain all over the body in last month 2.1 2.3 6.9 -1.2 -1.5 -1.3 -2.0 -1.4 1.5 0.0 -0.9 -1.4 -1.5 -1.2 -0.3 -0.9 -1.4 -1.8 -2.2 -2.0 -2.6 -2.1 -0.4 -1.3 -1.6 -1.9 0.2
Diabetes (self-reported) 12.3 19.1 33.4 5.7 4.3 4.3 1.5 4.5 -4.3 0.0 -0.5 5.7 4.3 5.0 4.9 5.4 5.4 4.4 3.8 5.2 4.2 4.3 -1.6 5.8 4.3 4.3 4.6
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.6 -0.7 -0.9 -1.0 -1.3 -0.8 0.9 0.0 -0.5 -0.4 -1.0 -0.6 -1.2 -1.0 -0.7 -0.7 -0.7 -0.6 -0.1 -0.4 -0.7 -0.8 -0.9 -0.6 -0.9
Medication: Ramipril 0.3 0.3 3.0 -0.1 -0.7 -0.7 -1.7 -0.6 0.6 0.0 0.3 -0.2 -0.7 0.1 -0.0 -0.3 -0.2 -0.4 -0.5 -0.8 -0.6 -0.6 0.0 -0.6 -0.6 -0.4 -0.1
Medication: Simvastatin 6.1 8.9 18.6 -3.2 -2.7 -2.7 -2.4 -3.1 2.6 0.0 2.0 -3.5 -2.7 -1.9 -2.3 -3.6 -3.2 -2.6 -2.8 -4.1 -3.6 -3.6 3.3 -4.3 -2.7 -3.9 -1.1
Fluid intelligence score 1.3 2.8 6.9 1.7 1.5 1.5 0.7 1.5 -1.7 0.0 -2.6 1.1 1.5 1.1 0.8 1.6 1.8 1.5 1.5 2.6 2.2 1.5 -1.9 2.2 1.6 2.2 -0.7
Illnesses of siblings 3.2 4.6 12.2 1.8 2.1 2.0 3.5 2.1 -2.2 0.0 1.0 2.5 2.0 1.6 1.7 2.2 1.8 2.3 3.0 2.5 2.1 2.3 1.2 2.5 2.1 2.6 1.6
Neuroticism score 1.5 3.3 7.8 -2.3 -1.7 -1.8 -0.7 -2.1 1.6 0.0 -2.8 -2.4 -1.7 -1.7 -1.1 -2.3 -2.3 -1.5 -1.9 -1.4 -1.3 -2.6 -1.9 -1.3 -1.6 -1.9 -1.1
Weight 3.1 15.5 35.2 4.3 3.6 3.8 2.7 4.0 -3.3 0.0 -4.5 3.8 3.6 3.2 4.2 5.3 4.2 3.1 2.5 5.1 3.0 3.0 -5.1 5.9 3.5 4.4 4.4
Impedance of arm (right) 3.4 16.3 87.4 -3.4 -2.4 -2.6 -2.2 -2.8 2.1 0.0 8.7 -2.8 -2.5 -1.4 -4.1 -5.0 -3.4 -2.0 -1.4 -5.2 -3.0 -1.9 9.3 -6.7 -2.3 -4.7 -0.5
Arm fat percentage (right) 0.1 0.2 2.5 -0.0 -0.1 -0.0 -0.2 -0.0 0.2 0.0 -0.7 -0.2 -0.1 0.1 -0.2 0.4 -0.2 -0.5 -0.5 -0.1 -0.9 -0.3 -0.7 -0.0 -0.2 -0.3 1.6
Trunk fat-free mass 6.8 39.9 97.6 6.6 5.6 5.8 5.0 6.1 -5.2 0.0 -7.9 6.2 5.7 4.2 6.3 8.3 6.7 5.2 4.1 8.3 5.8 4.9 -9.3 9.9 5.5 7.5 4.0
Hip circumference 1.0 4.3 16.3 2.4 1.4 1.5 0.2 1.6 -1.3 0.0 -3.3 2.1 1.4 1.6 2.1 2.7 2.2 1.1 1.1 2.8 1.2 1.1 -4.0 3.2 1.3 1.9 3.0
Time employed in main current job 0.2 0.2 1.0 -0.0 -0.5 -0.7 -1.0 -0.3 0.3 0.0 0.7 0.2 -0.5 0.0 -0.0 -0.2 -0.1 -0.2 -0.9 -0.4 0.1 0.1 -0.0 -0.6 -0.4 -0.2 -0.0
Alcohol intake versus 10 years previously 9.0 13.5 30.6 -3.9 -3.5 -3.4 -3.8 -3.6 3.6 0.0 2.9 -3.5 -3.5 -2.8 -4.0 -4.7 -3.8 -3.7 -2.8 -4.8 -4.1 -3.2 3.2 -5.5 -3.6 -4.4 -2.6
Father’s age at death 0.2 0.3 1.3 -0.8 -0.6 -0.6 0.0 -0.5 0.4 0.0 -0.3 -0.7 -0.6 -1.1 0.3 -0.2 -0.6 -0.6 -0.6 -0.3 -0.9 -0.3 -0.1 -0.2 -0.6 -0.4 -0.5
Worrier / anxious feelings 2.2 4.2 6.9 -2.4 -2.2 -2.3 -1.1 -2.3 2.2 0.0 -2.6 -2.2 -2.2 -2.6 -1.7 -1.8 -2.2 -1.8 -2.2 -1.9 -1.8 -2.3 -2.3 -1.5 -2.1 -1.6 -2.3
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 4.1 -1.4 -1.2 -1.1 -0.7 -1.4 1.2 0.0 -1.4 -2.0 -1.2 -0.6 -0.8 -1.5 -1.6 -1.4 -1.9 -1.4 -1.5 -1.9 -0.6 -1.4 -1.2 -1.8 0.4
Falls in the last year 0.8 1.1 3.0 -0.9 -0.8 -0.6 -1.1 -0.9 1.1 0.0 1.3 -0.3 -0.7 -0.2 -0.7 -1.4 -1.0 -1.1 -1.3 -1.6 -1.1 -1.2 1.0 -1.6 -0.8 -1.7 0.2
Hair/balding pattern: Pattern 3 1.9 2.9 4.0 1.9 1.8 1.8 1.1 1.8 -1.9 0.0 0.5 2.0 1.8 1.9 2.0 1.7 1.9 1.9 1.7 2.0 1.9 1.6 1.0 1.6 1.9 1.6 1.7
Number of live births 0.8 1.1 3.3 -0.7 -0.9 -0.9 -0.6 -0.8 1.2 0.0 0.7 -0.6 -0.9 -0.7 -1.1 -0.5 -0.7 -1.0 -1.6 -1.6 -1.6 -0.9 0.2 -1.4 -1.0 -1.0 -1.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.9 0.3 0.9 1.0 1.3 0.7 -0.8 0.0 -1.7 -0.5 1.0 0.8 0.4 0.3 0.2 0.7 0.7 1.1 0.9 -0.0 -0.7 0.9 0.9 0.9 0.4
Pulse rate 6.4 10.7 22.3 -3.6 -3.1 -3.1 -1.1 -3.1 3.3 0.0 2.0 -3.8 -3.2 -3.1 -3.6 -3.6 -3.5 -3.3 -2.8 -4.3 -3.8 -2.9 3.2 -4.7 -3.3 -3.8 -3.2
Happiness 0.6 0.7 3.6 -0.6 -0.6 -0.5 -1.9 -0.7 0.6 0.0 -0.5 -1.1 -0.5 -0.4 -1.1 -1.1 -0.5 -0.7 -0.5 -0.8 -0.3 -1.1 0.4 -1.1 -0.6 -0.9 -1.3
Noisy workplace 0.3 0.4 1.8 0.2 0.6 0.6 0.2 0.5 -0.6 0.0 1.3 0.3 0.6 0.9 0.6 -0.2 0.2 0.7 0.3 0.3 1.0 0.5 1.4 0.1 0.6 0.1 0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.2 5.3 -0.8 -1.2 -1.3 -0.2 -0.9 0.9 0.0 -2.0 -1.3 -1.2 -1.1 -1.0 -0.7 -1.0 -0.7 -1.2 -0.2 0.1 -0.3 -1.7 -0.4 -1.0 -0.4 -2.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 3.4 0.7 0.5 0.6 -0.5 0.6 -0.4 0.0 0.7 0.3 0.5 0.7 -0.2 0.3 0.9 0.4 -0.2 0.2 0.5 0.2 1.9 -0.3 0.5 -0.2 0.2
Mouth/teeth dental problems: Dentures 1.1 1.8 8.0 1.3 0.9 0.7 0.4 0.6 -0.9 0.0 -2.8 0.8 0.9 0.9 1.2 1.5 1.3 1.3 1.0 2.1 1.4 0.4 -2.1 2.3 0.9 2.0 -0.1
Asthma 0.1 0.2 1.5 -0.1 0.2 0.3 0.4 0.3 -0.1 0.0 1.2 0.5 0.2 -0.2 0.2 0.4 -0.1 -0.2 -0.4 -0.4 -0.6 0.2 0.7 -0.1 0.1 -0.5 0.4
Medication: Ibuprofen (e.g. Nurofen) 3.1 4.0 12.2 -1.2 -2.3 -2.3 -3.5 -2.3 2.4 0.0 -1.2 -1.6 -2.3 -1.3 -1.4 -1.8 -1.4 -2.3 -2.5 -2.0 -1.9 -2.4 -1.5 -1.9 -2.4 -2.3 -0.8
Medication: Cholesterol lowering 11.0 16.9 37.0 -4.8 -3.8 -3.8 -2.8 -4.2 3.9 0.0 1.7 -4.8 -3.8 -3.0 -3.3 -5.2 -4.7 -3.7 -3.8 -5.8 -4.8 -4.7 3.6 -6.1 -3.8 -5.1 -2.3
Depression (self-reported) 0.1 0.1 1.5 0.2 -0.0 -0.1 -0.3 -0.1 -0.0 0.0 0.9 0.4 -0.1 0.5 -0.2 -0.2 0.1 0.3 0.1 0.2 0.4 0.1 1.2 -0.2 0.0 0.1 0.0
Medication: Lansoprazole 0.3 0.3 1.0 -0.3 -0.7 -0.7 -0.8 -0.8 0.6 0.0 -0.6 -0.6 -0.7 -0.1 0.0 -0.5 -0.6 -0.5 -0.1 -0.5 -1.0 -0.8 -0.2 -0.4 -0.7 -0.3 0.6
Prospective memory result 0.2 0.3 1.5 0.5 0.5 0.4 -0.4 0.5 -0.3 0.0 1.2 0.6 0.5 0.4 0.4 0.3 0.7 0.5 0.4 0.3 0.6 0.6 0.7 0.2 0.4 0.3 0.7
Lung cancer (father) 0.6 0.7 2.0 -1.3 -0.8 -0.9 1.4 -0.7 1.0 0.0 -0.1 -0.7 -0.8 -1.3 -0.9 -0.9 -1.3 -0.8 -0.6 -0.7 -0.7 -0.4 -0.1 -0.8 -0.9 -0.7 -0.1
Illnesses of mother 2.6 3.2 6.4 1.7 2.0 2.1 2.0 2.3 -1.9 0.0 2.2 2.1 2.1 1.7 1.5 1.6 1.7 1.8 1.8 1.5 1.4 2.5 1.7 1.3 1.9 1.5 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 3.0 0.5 1.0 1.0 1.0 0.8 -0.9 0.0 -1.7 -0.1 1.0 0.7 0.5 0.4 0.6 0.8 0.9 1.4 1.0 0.4 -0.7 1.1 1.0 0.9 0.4
Pulse wave Arterial Stiffness index 0.2 0.2 0.9 -0.2 -0.2 -0.0 -0.7 -0.3 0.2 0.0 -1.0 -0.9 -0.1 0.5 0.6 -0.2 -0.5 -0.4 -0.1 -0.4 -0.3 -0.9 -0.6 -0.0 -0.2 -0.4 0.6
Impedance of arm (left) 3.3 15.5 98.6 -3.2 -2.1 -2.2 -2.1 -2.5 1.7 0.0 8.6 -2.8 -2.1 -0.9 -3.4 -4.8 -3.2 -1.8 -1.3 -5.0 -2.7 -1.8 9.9 -6.5 -1.9 -4.5 0.2
Arm fat mass (right) 0.9 3.8 8.9 2.0 1.6 1.8 1.3 1.9 -1.5 0.0 -2.7 1.7 1.6 1.5 2.0 2.9 1.9 1.2 0.8 2.4 1.0 1.3 -3.0 2.9 1.5 2.0 2.9
Trunk predicted mass 7.0 40.6 99.0 6.7 5.7 5.8 5.0 6.2 -5.3 0.0 -7.8 6.3 5.7 4.3 6.3 8.4 6.8 5.3 4.2 8.4 5.8 5.0 -9.2 9.9 5.6 7.6 4.0
Standing height 3.8 38.2 68.7 6.8 6.5 6.5 5.2 6.7 -6.3 0.0 -2.0 6.7 6.5 5.7 6.6 7.5 7.0 6.4 5.1 7.5 6.2 5.8 -2.9 8.3 6.5 7.0 6.0
Length of working week for main job 0.8 0.8 2.0 1.2 0.9 0.9 -0.1 0.9 -0.9 0.0 -0.1 1.2 0.9 0.8 0.7 0.6 1.2 0.6 1.3 1.4 1.1 1.0 -0.7 1.4 0.8 0.7 0.7
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.5 0.2 0.4 -0.5 0.5 -0.1 0.0 -0.0 0.3 0.3 0.5 0.2 0.1 0.4 -0.0 -0.5 0.1 0.1 0.3 -0.0 -0.2 0.1 -0.1 0.1
Breastfed as a baby 1.8 2.2 7.0 1.8 1.3 1.4 -0.5 1.5 -1.4 0.0 2.7 2.1 1.3 1.2 0.8 1.5 1.9 1.2 1.7 1.4 1.2 1.6 1.8 1.2 1.2 1.1 1.4
Tense / ‘highly strung’ 0.5 0.8 2.4 -1.5 -0.6 -0.6 0.5 -0.9 0.6 0.0 0.5 -1.1 -0.6 -0.5 -0.1 -1.6 -1.5 -0.5 -0.6 -1.3 -0.6 -1.2 0.5 -1.2 -0.6 -1.2 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 2.2 0.6 0.4 0.5 -1.2 0.3 -0.5 0.0 1.2 0.1 0.4 0.7 0.4 0.2 0.5 0.0 0.3 0.3 -0.0 -0.2 1.5 0.0 0.3 -0.1 1.2
Hair/balding pattern: Pattern 4 1.4 3.5 8.9 2.3 1.9 1.9 1.4 2.1 -1.8 0.0 1.3 2.0 1.9 2.0 3.0 2.7 2.2 1.9 1.3 1.2 1.2 1.9 0.1 2.0 1.9 1.7 2.0
Birth weight of first child 2.6 4.8 9.9 2.2 2.2 2.3 2.5 2.4 -2.0 0.0 1.2 2.7 2.3 1.4 1.7 2.0 2.4 2.1 3.1 2.7 2.8 2.8 0.2 2.2 2.2 2.9 0.7
Peak expiratory flow (PEF) 0.4 1.0 7.6 -1.2 -0.3 -0.1 0.4 -0.5 0.5 0.0 -2.8 -1.8 -0.2 -0.6 -0.2 -0.7 -1.2 -0.8 -1.1 -0.2 -0.5 -1.5 -1.9 -0.2 -0.4 -0.5 -0.3
Pulse wave reflection index 2.2 2.7 5.4 1.4 1.7 1.8 0.8 1.4 -1.6 0.0 -2.3 0.7 1.7 2.0 1.8 1.3 1.3 1.5 1.6 2.2 2.0 0.9 -1.5 2.1 1.6 1.8 2.1
Ever highly irritable/argumentative for 2 days 0.4 0.4 2.5 -0.8 -0.3 -0.2 -0.5 -0.7 0.5 0.0 -1.4 -1.0 -0.3 -0.2 -0.1 -0.6 -0.7 -0.4 -0.7 -0.6 -0.6 -1.6 -0.6 -0.3 -0.3 -0.6 -0.5
Loud music exposure frequency 0.3 0.3 1.3 0.3 0.6 0.6 0.7 0.6 -0.4 0.0 0.4 0.7 0.6 0.5 0.7 0.5 0.5 0.6 -0.2 0.1 0.1 0.2 -0.8 0.5 0.6 0.3 1.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 13.5 -0.9 -1.5 -1.6 -2.2 -1.3 1.3 0.0 -3.7 -1.6 -1.5 -1.6 -1.7 -1.2 -0.9 -1.2 -1.7 -0.4 -0.0 -1.2 -2.6 -0.8 -1.4 -0.8 -2.8
Mouth/teeth dental problems: Bleeding gums 3.8 5.0 12.1 -2.3 -2.1 -2.1 -1.2 -2.3 2.2 0.0 0.5 -2.5 -2.1 -1.4 -1.5 -2.4 -2.4 -2.2 -2.5 -3.5 -3.1 -2.9 0.8 -3.1 -2.2 -3.0 -1.3
Blood clot in the leg (DVT) 0.2 0.2 1.8 0.3 0.1 0.2 0.3 0.2 -0.2 0.0 -0.5 0.7 0.1 -0.1 0.8 0.8 0.3 -0.1 -0.6 -0.3 -0.8 -0.2 -1.4 0.5 0.1 -0.1 -0.5
Medication: Paracetamol 4.4 7.5 15.4 -2.5 -2.6 -2.4 -3.4 -2.9 2.9 0.0 -1.4 -3.2 -2.6 -1.7 -2.1 -2.8 -2.7 -3.0 -3.3 -3.7 -3.4 -3.9 -0.8 -3.2 -2.7 -3.7 -0.7
Headache pain in last month 4.4 7.7 13.0 -3.0 -2.8 -2.8 -2.9 -3.0 2.9 0.0 -0.5 -3.3 -2.8 -2.6 -3.5 -3.6 -2.9 -2.7 -2.4 -3.1 -2.7 -3.0 0.1 -3.4 -2.8 -3.1 -2.6
Medication for cholesterol, blood pressure or diabetes 4.7 7.7 15.2 2.9 3.0 3.1 2.5 3.2 -2.8 0.0 -0.2 3.1 3.0 2.0 1.8 3.0 3.0 2.6 2.9 3.9 3.6 3.4 -1.0 3.7 2.9 3.2 1.5
Glaucoma (self-reported) 0.2 0.2 1.8 -0.2 0.5 0.4 1.3 0.2 -0.4 0.0 -0.6 0.0 0.4 0.0 0.2 -0.1 -0.1 0.4 0.9 0.6 0.6 0.2 0.3 0.3 0.5 0.7 -0.3
Gout (self-reported) 35.6 48.9 100.0 -7.4 -7.3 -7.3 -5.7 -7.5 7.5 0.0 4.1 -7.0 -7.3 -6.0 -7.7 -8.6 -7.5 -7.1 -5.9 -8.6 -7.5 -6.6 4.4 -10.0 -7.4 -7.8 -5.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 1.8 0.2 0.1 0.1 -0.2 0.2 -0.0 0.0 1.3 0.1 0.1 0.2 0.2 0.2 0.1 -0.0 -0.3 -0.3 -0.3 0.0 1.3 -0.2 0.1 -0.4 -0.7
Medication: Amlodipine 0.4 0.5 2.9 0.4 -0.7 -0.8 -1.7 -0.7 0.6 0.0 0.8 0.3 -0.7 0.5 0.8 0.1 0.1 -0.4 -0.9 -0.7 -0.4 -0.5 -1.0 -0.3 -0.6 -0.3 1.4
Medication: Ventolin 100micrograms inhaler 1.7 2.2 3.3 -1.7 -1.7 -1.7 -0.1 -1.5 1.5 0.0 -0.5 -1.5 -1.8 -1.8 -1.0 -1.2 -1.8 -1.7 -1.6 -1.8 -1.8 -1.2 -0.6 -1.6 -1.8 -1.8 -1.2
Birth weight 0.1 0.3 1.3 -0.0 -0.3 -0.0 -0.9 -0.1 0.4 0.0 -0.7 0.1 -0.2 -0.7 -0.6 0.2 0.1 -0.7 -0.6 -0.4 -0.9 -0.7 -1.1 -0.1 -0.4 -0.5 -0.3
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.7 -0.9 -1.2 -1.1 -1.6 -1.2 1.2 0.0 -1.2 -0.8 -1.1 -0.8 -0.4 -0.8 -0.9 -1.2 -1.1 -1.0 -1.1 -1.5 -1.6 -0.6 -1.2 -1.1 -0.6
High blood pressure (siblings) 4.1 5.9 11.8 -2.2 -2.3 -2.2 -3.4 -2.4 2.4 0.0 0.1 -2.9 -2.2 -1.8 -2.2 -2.6 -2.0 -2.4 -3.1 -3.4 -2.8 -2.9 -0.0 -3.3 -2.3 -3.2 -1.3
Forced vital capacity (FVC), Best measure 0.5 1.9 3.7 1.4 1.5 1.5 1.6 1.4 -1.5 0.0 -0.8 1.0 1.5 1.3 1.4 1.3 1.4 1.4 1.4 1.9 1.4 1.2 -0.5 1.9 1.5 1.4 1.2
Body fat percentage 0.1 0.5 6.8 0.2 0.3 0.4 -0.3 0.3 -0.2 0.0 0.8 -0.1 0.3 0.8 0.5 0.3 0.0 -0.2 -0.1 -0.2 -0.9 -0.2 1.4 -0.3 0.2 -0.2 2.6
Leg fat percentage (right) 0.1 0.2 2.2 0.2 0.3 0.5 -0.1 0.3 -0.2 0.0 0.3 0.0 0.3 0.5 0.5 0.5 0.1 -0.2 0.1 -0.0 -0.9 -0.2 0.7 0.1 0.2 -0.0 1.5
Arm fat-free mass (right) 7.2 37.4 90.6 6.5 5.6 5.8 4.3 6.0 -5.2 0.0 -7.3 5.8 5.6 4.5 6.6 8.2 6.5 5.1 4.0 8.0 5.4 4.6 -8.1 9.5 5.4 7.4 4.5
Exposure to tobacco smoke outside home 0.3 0.4 5.2 -0.5 -0.0 0.0 0.1 -0.3 0.3 0.0 -2.3 -1.1 0.0 -0.3 -0.4 -0.4 -0.4 -0.2 -0.2 -0.0 -0.1 -1.1 -1.3 -0.1 -0.0 0.0 -0.6
Comparative body size at age 10 3.2 9.0 17.9 -3.1 -3.0 -2.8 -3.6 -3.0 3.2 0.0 -0.7 -3.2 -3.0 -2.7 -4.2 -3.9 -3.1 -3.4 -2.1 -3.1 -3.0 -3.0 0.5 -3.9 -3.1 -3.4 -2.8
Number of full brothers 1.7 2.1 5.1 1.7 1.8 2.0 0.4 1.8 -1.6 0.0 2.2 1.9 1.9 1.7 0.5 1.2 1.8 1.4 1.5 0.9 1.0 1.4 1.4 0.9 1.7 1.4 0.4
Worry too long after embarrassment 1.6 2.8 13.2 -1.8 -1.5 -1.7 0.1 -1.6 1.3 0.0 -3.6 -1.5 -1.5 -2.0 -1.7 -1.5 -1.7 -1.2 -1.8 -0.1 -0.4 -1.4 -3.1 -0.2 -1.3 -1.0 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.2 8.9 1.6 2.0 2.0 1.8 1.9 -1.9 0.0 1.7 1.4 2.0 2.2 1.8 1.7 1.3 1.7 2.0 1.2 1.0 1.3 2.5 1.2 1.9 1.6 3.0
Wheeze or whistling in the chest in last year 1.0 1.8 3.7 -1.5 -1.4 -1.2 0.1 -1.2 1.4 0.0 -1.9 -1.5 -1.4 -1.6 -0.8 -1.1 -1.5 -1.7 -1.5 -1.0 -1.8 -1.2 -1.5 -0.9 -1.5 -1.3 -1.0
Number of children fathered 1.0 1.1 3.3 0.7 1.0 1.0 0.7 0.7 -1.1 0.0 -1.3 0.4 1.0 1.1 1.8 1.0 0.3 0.8 1.1 1.3 0.7 0.1 -1.3 1.6 0.9 1.5 1.8
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 5.2 2.0 1.7 1.8 1.3 1.9 -1.6 0.0 0.5 2.3 1.7 1.7 2.1 2.2 1.9 1.6 1.4 1.7 1.9 1.6 -1.1 2.1 1.7 2.1 0.1
Age at first live birth 0.9 1.6 3.8 -1.0 -1.6 -1.6 -1.7 -1.4 1.2 0.0 -0.7 -1.3 -1.6 -1.7 -0.8 -1.3 -1.1 -1.5 -0.6 -0.8 -1.0 -0.8 -1.0 -0.9 -1.5 -0.9 -2.0
Pulse wave peak to peak time 0.5 0.6 2.0 0.8 0.6 0.5 0.9 0.8 -0.7 0.0 0.6 1.4 0.6 0.0 -0.1 0.8 1.1 0.9 0.4 1.0 0.8 1.3 0.2 0.7 0.7 0.9 -0.1
Health satisfaction 4.7 6.0 8.9 -2.8 -2.7 -2.7 -2.1 -2.9 2.6 0.0 0.3 -2.4 -2.7 -2.3 -2.5 -2.9 -2.7 -2.6 -2.5 -3.0 -2.8 -2.8 0.1 -2.8 -2.6 -3.0 -0.8
Shortness of breath walking on level ground 0.2 0.2 1.3 0.2 0.3 0.3 0.1 0.2 -0.4 0.0 0.5 0.4 0.3 0.7 0.4 0.0 0.1 0.4 0.7 0.2 0.3 0.2 0.5 0.5 0.4 0.0 1.1
Qualifications: College or University degree 0.3 0.9 2.6 -0.9 -1.1 -1.0 -1.2 -0.9 0.9 0.0 -0.2 -0.8 -1.1 -1.1 -1.0 -1.3 -1.0 -1.1 -0.6 -0.6 -0.4 -0.5 -0.5 -1.1 -1.1 -0.8 -1.6
Eye problems/disorders: None of the above 4.1 4.8 7.2 2.5 2.4 2.4 1.5 2.7 -2.4 0.0 1.3 2.3 2.5 2.6 1.6 2.2 2.7 2.5 1.9 2.0 2.4 2.6 1.8 1.6 2.4 1.8 2.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.3 -0.3 -0.4 -0.4 -0.9 -0.5 0.2 0.0 0.7 -0.6 -0.4 -0.3 -0.4 -0.4 -0.3 -0.5 -0.1 -0.9 -1.1 -0.7 1.1 -0.8 -0.4 -0.5 0.0
Emphysema/chronic bronchitis 0.3 0.4 1.2 0.9 0.4 0.2 0.8 0.4 -0.6 0.0 -0.1 0.5 0.3 0.3 0.7 1.1 0.8 0.4 0.2 1.0 0.3 0.4 -0.2 1.1 0.4 0.9 0.0
Medication for pain relief, constipation, heartburn 6.4 11.0 24.4 2.8 3.6 3.6 4.9 3.9 -3.6 0.0 2.2 3.5 3.6 2.1 2.4 3.4 3.1 3.5 3.9 3.6 3.7 4.4 1.7 3.3 3.6 4.1 0.9
Neck or shoulder pain in last month 0.3 0.4 1.9 -0.1 -0.0 0.2 -0.2 0.0 0.3 0.0 -0.2 -0.2 0.1 0.1 0.9 0.6 -0.0 -0.3 -1.4 -1.1 -1.1 -0.9 -1.2 -0.0 -0.1 -0.6 0.9
Medication: Blood pressure 1.0 1.9 4.2 -1.1 -1.4 -1.5 -1.5 -1.5 1.4 0.0 -1.8 -1.4 -1.4 -0.9 -0.3 -0.8 -1.2 -1.3 -2.1 -1.6 -1.8 -1.8 -1.6 -1.0 -1.4 -1.3 -0.4
Angina (self-reported) 1.7 2.3 5.6 -2.1 -1.4 -1.5 -0.2 -1.7 1.4 0.0 -0.8 -2.0 -1.4 -0.8 -0.5 -1.9 -2.4 -1.2 -1.2 -2.0 -1.9 -2.0 1.1 -2.1 -1.3 -1.5 0.3
Migraine (self-reported) 0.6 0.7 2.3 -0.5 -1.0 -1.2 -1.5 -1.4 0.4 0.0 -0.8 -0.8 -1.0 -0.2 -0.6 -0.8 -0.7 -0.4 -0.8 -0.6 -0.9 -1.4 0.2 -0.7 -0.8 -0.6 0.1
Medication: Ibuprofen 2.0 2.4 9.2 -0.9 -1.7 -1.7 -3.0 -1.8 1.9 0.0 -0.3 -1.3 -1.7 -0.8 -1.4 -1.6 -1.0 -1.7 -1.6 -1.8 -1.4 -1.9 -0.8 -1.8 -1.8 -1.8 -0.7
Medication: Allopurinol 24.3 32.2 74.1 -5.8 -5.6 -5.7 -4.7 -5.7 5.7 0.0 4.4 -5.7 -5.7 -4.7 -6.1 -6.8 -5.8 -5.6 -4.7 -7.3 -6.2 -5.0 5.0 -8.6 -5.7 -6.5 -4.7
Medication: Omeprazole 0.4 0.5 2.4 -0.5 -0.7 -0.7 -0.8 -0.7 0.6 0.0 -1.2 -0.7 -0.7 -0.6 -0.3 0.0 -0.5 -0.4 -0.9 -0.5 -0.6 -0.9 -1.5 0.0 -0.6 -0.4 0.1
Medication: Seretide 50 evohaler 0.3 0.3 2.0 0.7 0.6 0.8 0.4 0.9 -0.5 0.0 0.2 1.4 0.6 0.3 0.3 0.6 0.8 0.3 0.2 0.7 0.2 0.8 -0.0 0.5 0.5 0.6 -0.2
Mean time to correctly identify matches 0.3 0.6 1.9 -0.9 -1.0 -1.0 -0.6 -0.7 0.9 0.0 0.5 0.1 -1.0 -1.4 -1.1 -0.3 -0.8 -0.8 -0.8 -0.7 -0.6 -0.2 -0.0 -0.7 -1.0 -0.4 -1.2
Heart disease (mother) 2.3 2.8 4.5 -1.8 -1.9 -1.9 -1.2 -1.9 1.8 0.0 -1.0 -2.1 -1.9 -1.9 -1.5 -1.5 -1.7 -1.9 -1.8 -1.9 -1.6 -2.1 -0.2 -1.7 -1.9 -1.6 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.0 -1.7 -1.3 -1.3 -0.5 -1.3 1.4 0.0 -0.1 -1.7 -1.3 -1.6 -0.7 -1.3 -1.6 -1.1 -1.3 -1.2 -1.1 -1.0 -0.8 -1.2 -1.2 -0.8 -1.1
Whole body fat mass 0.9 4.1 12.4 2.2 2.0 2.1 1.3 2.1 -1.8 0.0 -1.6 1.9 2.0 1.9 2.4 2.9 2.1 1.5 1.1 2.4 1.0 1.5 -1.6 2.8 1.8 2.1 3.5
Leg fat mass (right) 1.2 4.8 10.6 2.3 2.1 2.2 1.6 2.3 -1.9 0.0 -2.2 2.0 2.1 1.9 2.7 3.3 2.2 1.6 1.2 2.7 1.1 1.5 -2.1 3.3 2.0 2.4 3.0
Arm predicted mass (right) 6.8 35.3 86.7 6.3 5.3 5.5 4.1 5.7 -4.9 0.0 -7.5 5.6 5.3 4.2 6.4 7.9 6.3 4.8 3.7 7.8 5.2 4.3 -8.5 9.3 5.1 7.2 4.3
Pulse rate, automated reading 9.7 31.8 71.2 -6.3 -5.2 -5.0 -2.7 -5.3 5.4 0.0 4.3 -6.0 -5.2 -5.1 -6.4 -6.6 -6.1 -5.7 -4.5 -7.5 -6.5 -5.1 5.7 -8.4 -5.4 -6.8 -4.6
Alcohol intake frequency. 19.6 46.4 110.2 -7.2 -6.0 -5.8 -5.5 -6.5 6.4 0.0 6.5 -6.4 -6.0 -4.9 -7.7 -9.1 -7.1 -6.6 -4.5 -8.9 -7.6 -6.2 8.1 -10.5 -6.2 -8.5 -4.0
Comparative height size at age 10 3.7 20.8 43.7 4.7 4.4 4.4 3.7 4.6 -4.3 0.0 -3.3 4.9 4.5 3.8 4.3 5.4 4.9 4.5 3.3 5.9 5.1 4.2 -4.7 6.6 4.5 5.4 4.3
Number of full sisters 0.1 0.1 1.1 -0.3 0.3 0.4 0.1 0.3 -0.1 0.0 -0.5 -0.8 0.3 -0.0 0.1 -0.0 -0.2 0.1 0.0 -0.1 -0.1 -0.2 -0.0 -0.2 0.2 0.2 -1.1
Suffer from ‘nerves’ 0.2 0.3 2.7 -0.5 0.1 0.0 0.2 -0.3 -0.3 0.0 -1.6 -0.6 0.1 -0.0 -0.1 -0.2 -0.5 0.2 -0.2 0.4 0.5 -0.8 -0.8 0.5 0.2 0.1 -0.4
Overall health rating 3.4 7.3 14.4 -3.4 -2.4 -2.2 -0.8 -2.7 2.9 0.0 -0.7 -3.5 -2.4 -2.0 -1.6 -3.1 -3.4 -2.8 -3.5 -3.8 -3.5 -3.6 -0.3 -3.3 -2.6 -3.4 -0.7
Chest pain or discomfort 1.6 2.3 4.1 -1.7 -1.5 -1.5 -0.1 -1.6 1.7 0.0 0.5 -1.7 -1.5 -1.4 -1.5 -2.0 -1.8 -1.8 -1.4 -1.7 -1.6 -1.6 -0.3 -2.0 -1.5 -1.9 -1.4
Had major operations 0.7 0.8 3.1 -0.7 -1.1 -1.2 -0.9 -1.2 0.6 0.0 0.5 -0.9 -1.1 -0.9 0.1 -0.3 -0.9 -1.0 -1.1 -1.1 -1.8 -1.0 0.2 -0.6 -1.0 -1.0 -0.5
Age at last live birth 0.1 0.2 2.0 0.3 -0.4 -0.3 -0.8 -0.2 0.2 0.0 1.4 0.1 -0.4 -0.2 0.2 -0.1 0.1 -0.5 0.2 -0.0 -0.4 0.4 0.7 -0.1 -0.4 -0.0 -0.7
Family relationship satisfaction 2.6 3.1 5.2 1.9 2.0 2.0 0.8 1.9 -2.0 0.0 -0.3 1.7 2.0 1.8 2.1 2.2 2.0 1.9 2.0 1.8 1.6 1.6 0.1 2.3 2.0 2.0 1.8
Leg pain on walking 0.3 0.4 1.3 0.5 0.5 0.5 0.5 0.2 -0.6 0.0 -1.0 0.0 0.5 0.9 0.9 0.7 0.3 0.5 -0.4 0.1 0.2 -0.4 -1.2 1.0 0.5 -0.1 0.8
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 5.8 -1.6 -1.3 -1.2 -1.1 -1.5 1.7 0.0 -0.7 -1.6 -1.3 -1.2 -1.4 -1.6 -1.4 -1.6 -2.4 -2.0 -2.1 -2.2 -0.5 -1.7 -1.4 -1.8 -1.7
Commuting to job workplace: Car/motor vehicle 0.6 0.6 4.5 -0.1 -0.9 -1.0 -2.1 -1.0 0.7 0.0 0.8 -0.1 -1.0 -0.2 -0.1 -0.1 -0.4 -0.7 -0.9 -1.0 -0.8 -1.1 0.7 -0.5 -0.9 -0.6 0.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.7 0.9 0.2 0.2 0.5 0.6 -0.4 0.0 0.3 1.3 0.2 -0.1 0.6 1.1 0.8 0.2 0.2 0.4 0.1 1.1 -0.8 0.6 0.1 0.6 -0.5
Medication: Aspirin 1.1 1.5 3.6 -1.2 -1.3 -1.3 -1.9 -1.5 1.4 0.0 0.3 -1.3 -1.3 -0.4 -0.6 -1.9 -1.4 -1.0 -1.0 -1.4 -1.1 -1.4 0.4 -1.6 -1.2 -1.3 -0.2
Supplements: Vitamin C 0.4 0.5 3.4 0.1 -0.6 -0.4 -1.9 -0.4 0.7 0.0 0.2 0.1 -0.5 -0.3 -0.1 0.2 0.2 -0.8 -1.2 -0.9 -1.1 -0.8 -0.8 -0.3 -0.7 -0.8 0.4
Knee pain experienced in last month 0.5 0.8 4.1 1.1 0.8 0.6 -0.5 0.5 -0.8 0.0 1.4 0.5 0.7 1.8 1.5 0.5 0.9 1.0 0.0 -0.0 0.4 0.4 0.8 0.2 0.8 -0.0 2.0
Hypertension (Self-reported) 2.0 5.7 12.9 -2.2 -2.5 -2.5 -2.5 -2.6 2.5 0.0 -0.9 -2.6 -2.5 -1.7 -1.0 -1.9 -2.3 -2.4 -3.6 -3.3 -3.1 -3.1 -1.1 -2.7 -2.5 -3.1 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.2 -0.8 -1.0 -1.1 -1.0 -1.1 1.0 0.0 0.2 -0.7 -1.0 -1.0 -0.7 -0.8 -0.8 -0.7 -0.6 -0.9 -1.1 -1.0 -0.3 -0.7 -1.0 -0.5 -0.8
Illnesses of father: Heart disease 2.5 3.5 7.5 -2.2 -1.4 -1.1 -1.6 -1.6 1.6 0.0 0.7 -2.0 -1.4 -1.5 -1.7 -2.1 -2.0 -1.9 -1.7 -2.7 -2.4 -2.4 1.8 -2.7 -1.5 -2.6 -1.8
Illnesses of siblings: Diabetes 1.1 1.3 12.0 0.6 0.4 0.4 0.6 0.7 -0.3 0.0 -2.5 0.6 0.4 0.1 1.2 1.1 0.6 0.6 -0.3 1.2 1.3 0.8 -3.5 1.7 0.5 1.1 0.3
Smoking status: Previous 0.3 0.5 4.8 0.6 0.0 -0.0 -1.2 0.2 -0.1 0.0 2.2 1.1 0.0 0.3 0.4 0.8 0.6 0.1 -0.3 -0.4 -0.6 0.6 1.0 -0.1 -0.0 -0.2 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 4.9 1.9 1.7 1.8 1.2 1.9 -1.7 0.0 -0.3 1.8 1.8 1.1 1.6 2.1 2.2 1.6 1.4 1.8 1.7 1.6 -0.9 1.8 1.7 1.8 1.2
Whole body fat-free mass 6.2 36.2 87.6 6.3 5.3 5.4 4.5 5.8 -4.9 0.0 -7.7 5.8 5.3 4.0 6.1 8.0 6.3 4.9 3.8 7.9 5.3 4.6 -9.0 9.4 5.2 7.2 4.1
Leg fat-free mass (right) 4.4 24.1 63.5 5.1 4.1 4.2 3.4 4.6 -3.8 0.0 -7.0 4.6 4.2 3.4 4.9 6.5 5.1 3.8 2.9 6.4 4.2 3.7 -8.0 7.5 4.0 5.8 3.9
Arm fat percentage (left) 0.1 0.3 4.2 0.1 0.0 0.1 -0.2 0.1 0.0 0.0 -0.8 -0.3 0.0 0.4 0.2 0.5 -0.1 -0.4 -0.4 -0.1 -0.9 -0.3 -0.4 0.0 -0.1 -0.2 2.1
Average weekly red wine intake 0.5 0.7 2.3 1.2 0.4 0.3 -0.1 0.6 -0.7 0.0 -0.4 1.3 0.4 0.7 1.2 1.5 1.1 0.9 0.3 0.8 0.8 0.8 -1.4 1.3 0.6 1.2 0.3
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.3 0.7 1.0 1.0 0.5 1.0 -1.0 0.0 -0.4 0.1 1.1 0.6 0.8 0.7 0.8 1.0 0.8 1.0 1.5 0.5 1.0 0.6 1.1 0.9 0.1
Mood swings 2.4 4.3 8.7 -2.3 -2.2 -2.2 -1.9 -2.5 2.1 0.0 -1.8 -2.7 -2.2 -1.8 -1.3 -2.3 -2.4 -2.0 -2.0 -2.2 -2.5 -2.9 -1.2 -2.0 -2.1 -2.2 -1.0
Loneliness, isolation 1.6 2.2 5.2 -2.2 -1.5 -1.5 -0.2 -1.8 1.4 0.0 0.2 -1.6 -1.5 -1.7 -0.7 -1.9 -2.3 -1.5 -1.1 -1.7 -1.8 -1.9 -0.1 -1.5 -1.5 -1.6 -0.8
Long-standing illness, disability or infirmity 0.3 0.5 1.0 -0.7 -0.7 -0.7 -1.0 -0.9 0.8 0.0 0.6 -0.3 -0.7 0.0 -0.1 -0.8 -0.8 -0.6 -0.9 -0.8 -0.8 -0.9 -0.5 -0.5 -0.6 -1.0 0.2
Ever had bowel cancer screening 1.3 1.5 3.9 -1.0 -1.2 -1.2 -1.2 -1.0 1.3 0.0 1.9 -0.5 -1.2 -1.0 -0.8 -1.1 -1.0 -1.3 -1.0 -2.0 -1.7 -0.8 1.0 -1.8 -1.4 -1.4 -0.6
Diabetes diagnosed by doctor 12.5 20.7 39.0 5.7 4.4 4.4 2.1 4.6 -4.4 0.0 -1.6 5.6 4.5 5.0 5.2 5.6 5.4 4.6 3.8 5.5 4.4 4.3 -2.6 6.2 4.5 4.8 4.6
Ever had stillbirth, spontaneous miscarriage or termination 3.9 4.2 6.2 -2.0 -2.2 -2.1 -1.8 -2.3 2.2 0.0 -0.9 -2.4 -2.2 -2.0 -2.1 -2.0 -2.0 -2.4 -2.5 -2.1 -2.3 -2.5 -0.3 -2.1 -2.3 -2.4 -1.4
Friendships satisfaction 0.1 0.1 1.3 -0.1 -0.1 0.1 0.2 -0.1 0.1 0.0 0.2 -0.2 -0.0 -0.2 -0.3 -0.1 0.0 -0.2 0.0 -0.3 -0.2 -0.4 0.6 -0.3 -0.1 -0.0 -1.1
Qualifications: nursing, teaching 1.2 1.9 5.7 -0.5 -1.8 -1.8 -2.4 -1.4 1.6 0.0 -1.1 -1.0 -1.9 -1.6 -0.7 -0.9 -0.7 -1.9 -1.7 -0.6 -1.2 -0.9 -1.2 -0.9 -1.8 -1.6 -0.8
Commuting to job workplace: Walk 0.1 0.1 0.6 -0.1 0.4 0.4 -0.8 0.3 -0.3 0.0 0.0 -0.0 0.4 -0.2 -0.7 -0.4 0.3 0.5 0.5 0.3 0.7 0.1 0.3 -0.3 0.5 0.1 -0.4
Eye problems/disorders: Cataract 7.5 8.7 12.2 -3.0 -3.3 -3.2 -2.9 -3.4 3.3 0.0 -0.7 -2.9 -3.3 -3.1 -2.6 -3.3 -3.3 -3.5 -2.7 -3.1 -3.4 -3.2 -1.7 -2.8 -3.3 -3.2 -2.7
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.8 -0.9 -1.1 -1.1 -1.0 -1.1 1.2 0.0 0.7 -1.1 -1.1 -0.9 -1.0 -1.1 -0.9 -1.2 -1.7 -1.2 -1.4 -1.0 0.2 -1.2 -1.2 -1.3 -1.4
Medication for cholesterol 4.2 6.4 15.1 2.0 2.3 2.1 3.6 2.4 -2.2 0.0 -2.2 2.7 2.2 1.0 1.5 2.9 2.1 2.5 2.4 3.7 3.2 2.7 -2.5 3.9 2.3 3.5 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 4.9 -1.1 -1.2 -1.2 -1.6 -1.6 1.3 0.0 2.2 -1.0 -1.2 0.1 -1.7 -2.0 -1.3 -1.3 -0.8 -1.7 -1.7 -1.7 2.2 -1.9 -1.2 -1.9 1.3
Back pain experienced in last month 0.9 1.4 4.0 -1.2 -1.0 -1.0 -0.5 -1.2 1.1 0.0 -2.0 -1.6 -0.9 -0.8 -0.3 -0.7 -1.1 -0.9 -1.5 -1.6 -1.6 -1.8 -1.8 -0.8 -1.0 -1.1 -0.4
Mineral and other dietary supplements 0.1 0.1 0.5 0.2 0.0 -0.1 0.3 0.1 0.0 0.0 -0.6 0.4 -0.0 0.1 -0.3 0.3 0.1 0.4 0.3 0.6 0.7 0.5 -0.6 0.3 0.1 0.4 -0.3
Breast cancer (self-reported) 0.1 0.2 0.6 -0.4 -0.6 -0.8 -0.5 -0.7 0.3 0.0 -0.1 -0.3 -0.7 -0.7 0.2 -0.0 -0.4 -0.3 -0.0 0.0 -0.2 -0.3 -0.4 0.1 -0.5 0.2 -0.4
Asthma (self-reported) 0.1 0.2 2.0 -0.4 -0.1 -0.0 0.2 0.0 0.2 0.0 1.4 0.3 -0.2 -0.4 -0.4 0.0 -0.3 -0.4 -0.5 -0.8 -0.8 0.1 0.7 -0.5 -0.2 -0.8 0.2
Osteoporosis (self-reported) 4.6 5.7 10.5 -2.5 -2.4 -2.2 -2.6 -2.5 2.4 0.0 0.5 -2.6 -2.4 -1.9 -2.7 -3.0 -2.7 -2.7 -1.8 -2.8 -3.0 -2.4 1.3 -3.2 -2.5 -3.0 -1.1
Osteoarthritis (self-reported) 0.5 0.7 1.9 1.3 0.5 0.7 -1.2 0.7 -0.4 0.0 1.1 1.1 0.6 1.3 0.8 1.0 1.1 0.1 -0.3 -0.2 -0.4 0.3 1.4 0.1 0.4 0.1 1.3
Medication: Aspirin 1.2 1.6 3.4 -1.3 -1.4 -1.5 -1.9 -1.7 1.5 0.0 0.3 -1.2 -1.4 -0.8 -0.5 -1.8 -1.4 -1.1 -1.1 -1.4 -1.3 -1.4 0.2 -1.4 -1.3 -1.2 -0.7
Medication: Gliclazide 4.0 4.6 8.9 2.3 1.9 1.9 2.1 2.2 -2.0 0.0 0.1 2.9 1.9 1.5 2.1 2.8 2.3 2.2 2.0 2.6 2.3 2.5 -0.7 3.0 2.0 2.7 2.0
Illnesses of father: None of the above (group 1) 0.4 0.5 3.3 0.1 -0.9 -1.1 0.1 -0.7 0.5 0.0 -1.4 0.0 -0.9 -0.7 -0.9 -0.1 -0.2 -0.4 -0.3 0.7 0.2 0.2 -1.8 0.5 -0.8 -0.0 -0.1
Smoking status: Current 0.3 0.4 1.8 -1.1 -0.3 -0.4 1.0 -0.4 0.5 0.0 0.7 -1.0 -0.3 -0.5 -0.5 -0.8 -0.8 -0.4 -0.3 -0.7 -0.4 -0.5 1.3 -1.0 -0.4 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.3 -0.7 -0.7 -0.8 -0.5 -0.7 0.6 0.0 -0.5 -1.3 -0.7 -0.6 -0.7 -0.7 -0.7 -0.6 -0.7 -0.7 -0.2 -0.7 0.7 -1.0 -0.7 -0.6 -1.5
Whole body water mass 6.3 36.8 89.1 6.3 5.3 5.5 4.6 5.8 -4.9 0.0 -7.9 5.8 5.4 4.1 6.1 8.1 6.4 4.9 3.8 8.0 5.4 4.6 -9.2 9.4 5.2 7.2 4.2
Leg predicted mass (right) 4.5 24.3 64.3 5.1 4.2 4.3 3.5 4.7 -3.8 0.0 -7.0 4.6 4.2 3.4 5.0 6.5 5.1 3.8 2.9 6.4 4.2 3.7 -8.0 7.5 4.0 5.8 3.9
Arm fat mass (left) 0.9 3.9 9.1 2.0 1.6 1.8 1.2 1.9 -1.5 0.0 -2.9 1.6 1.7 1.6 2.1 2.9 1.9 1.2 0.8 2.4 1.0 1.1 -3.0 2.9 1.5 2.0 3.0
Number of self-reported non-cancer illnesses 7.1 12.3 23.5 -3.7 -3.6 -3.6 -3.2 -3.7 3.6 0.0 1.5 -3.4 -3.6 -2.9 -3.0 -3.7 -3.8 -3.6 -3.5 -4.8 -4.5 -3.9 1.8 -4.7 -3.6 -4.5 -2.2
Average weekly champagne plus white wine intake 0.6 0.8 4.6 0.7 0.3 0.3 0.9 0.6 -0.2 0.0 -2.0 0.6 0.3 0.1 0.8 1.2 0.5 0.3 -0.1 1.2 0.9 0.7 -2.1 1.2 0.3 1.1 0.3
Miserableness 2.1 3.6 6.5 -2.1 -1.7 -1.8 -1.3 -2.1 1.8 0.0 -1.1 -2.4 -1.7 -1.4 -2.0 -2.5 -2.2 -1.7 -1.7 -2.2 -2.2 -2.5 0.1 -2.4 -1.8 -2.3 -1.8
Guilty feelings 0.4 0.6 8.0 -0.4 0.3 0.4 0.5 -0.0 -0.0 0.0 -2.8 -0.8 0.4 0.5 0.3 -0.7 -0.4 0.4 -0.2 0.2 0.8 -0.7 -1.5 0.2 0.3 -0.4 0.9
Wears glasses or contact lenses 0.1 0.2 0.5 0.1 -0.6 -0.5 -0.7 -0.4 0.4 0.0 0.1 -0.1 -0.6 -0.0 0.4 -0.1 -0.2 -0.5 -0.4 -0.4 -0.5 -0.2 0.1 -0.1 -0.6 -0.5 0.7
Ever taken oral contraceptive pill 0.4 0.4 3.7 0.6 -0.6 -0.7 0.1 -0.2 0.6 0.0 -1.1 0.8 -0.6 0.0 -0.1 0.6 0.5 -0.1 -0.8 0.2 0.2 0.3 -1.9 0.4 -0.5 0.1 -0.6
Hearing aid user 1.8 2.1 5.2 -2.2 -1.5 -1.7 0.6 -1.5 1.4 0.0 -0.1 -1.8 -1.5 -1.9 -1.1 -1.4 -1.9 -0.9 -1.4 -1.8 -1.1 -1.2 0.2 -1.9 -1.3 -0.9 -2.3
Mother’s age at death 1.4 1.7 4.1 1.6 0.9 0.7 0.1 1.2 -1.3 0.0 1.9 2.0 0.9 1.2 0.9 1.5 1.6 1.4 1.0 1.2 1.2 1.7 1.6 1.1 1.1 0.8 2.0
Financial situation satisfaction 0.3 0.4 2.7 -0.1 -0.7 -0.7 -1.6 -0.8 0.6 0.0 -0.6 -0.4 -0.8 -0.2 -0.3 -0.4 -0.2 -0.7 -0.4 -0.4 -0.7 -0.9 -0.6 -0.4 -0.7 -0.5 -0.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.0 -0.7 -1.2 -1.3 -0.2 -1.1 1.1 0.0 0.1 -0.6 -1.2 -1.0 -0.7 -0.7 -0.8 -0.9 -1.3 -1.0 -0.8 -0.7 -0.5 -0.8 -1.1 -1.0 -1.7
Commuting to job workplace: Public transport 1.1 1.3 4.3 0.8 1.5 1.5 2.1 1.4 -1.4 0.0 -0.5 0.2 1.5 0.9 0.9 0.7 0.9 1.3 0.9 1.5 1.7 1.3 0.2 0.9 1.5 1.1 -0.2
Eye problems/disorders: Glaucoma 0.2 0.3 1.3 -0.1 0.3 0.3 1.2 0.2 -0.3 0.0 -1.0 0.1 0.3 0.1 0.4 -0.0 -0.2 0.4 0.8 0.8 0.8 0.3 -0.4 0.6 0.4 0.7 -0.5
Medication: Blood pressure 1.2 2.3 5.2 -1.2 -1.6 -1.6 -2.1 -1.7 1.4 0.0 0.9 -1.7 -1.6 -0.5 -0.4 -1.6 -1.3 -1.4 -1.7 -2.3 -1.9 -1.8 0.7 -2.1 -1.5 -2.2 0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 4.2 1.7 1.2 1.1 0.4 1.1 -1.1 0.0 -0.0 1.6 1.2 2.0 1.7 1.3 1.4 1.3 0.2 1.0 0.8 0.9 -0.1 1.2 1.2 0.8 1.6
Supplements: Fish oil (including cod liver oil) 0.7 1.0 1.7 -0.9 -1.1 -1.1 -1.2 -1.3 1.0 0.0 0.3 -1.0 -1.1 -0.8 -0.4 -1.1 -0.9 -1.2 -1.0 -1.3 -1.3 -1.3 -0.2 -0.9 -1.1 -1.2 0.2
High cholesterol (Self-reported) 24.5 42.9 93.8 -7.6 -6.1 -6.0 -4.2 -6.7 6.1 0.0 3.6 -7.7 -6.1 -5.3 -6.0 -8.5 -7.4 -6.2 -5.8 -8.8 -7.1 -6.9 5.8 -9.7 -6.1 -8.2 -4.2
Medication: Bendroflumethiazide 0.2 0.3 1.0 -0.4 -0.6 -0.7 -0.4 -0.8 0.4 0.0 0.2 -1.0 -0.6 -0.1 -0.1 -0.5 -0.4 -0.3 -0.6 -0.9 -0.4 -0.9 0.5 -0.7 -0.5 -0.4 -0.3
Medication: Paracetamol 3.0 4.7 10.8 -2.1 -2.0 -1.8 -2.7 -2.3 2.2 0.0 -0.5 -2.6 -1.9 -1.0 -1.2 -2.4 -2.2 -2.2 -2.3 -3.2 -2.9 -3.3 0.1 -2.8 -2.1 -2.9 -0.3
Medication: Lisinopril 0.5 0.7 7.8 -0.3 -0.5 -0.5 0.3 -0.5 0.3 0.0 -2.8 -0.3 -0.5 -0.2 0.6 -0.1 -0.5 -0.4 -1.3 0.2 -0.5 -0.6 -1.5 0.3 -0.5 -0.6 0.8
Medication: Atorvastatin 14.9 18.4 38.3 -5.1 -4.2 -4.2 -3.0 -4.6 4.4 0.0 1.6 -4.9 -4.2 -3.4 -3.9 -5.9 -5.0 -4.2 -3.7 -5.5 -4.7 -4.3 3.1 -6.2 -4.2 -5.4 -2.2
Illnesses of father: High blood pressure 1.4 1.8 3.4 -1.2 -1.3 -1.2 -1.8 -1.2 1.4 0.0 -1.4 -1.7 -1.3 -1.3 -0.6 -1.1 -0.9 -1.4 -1.8 -1.6 -1.2 -1.6 -0.8 -1.5 -1.4 -1.6 -1.1
Alcohol drinker status: Never 0.5 0.6 4.1 -0.6 -0.1 -0.0 0.2 -0.3 0.4 0.0 1.7 -0.7 -0.1 -0.1 -0.3 -0.8 -0.8 -0.7 0.0 -0.9 -1.1 -0.7 2.0 -0.9 -0.3 -1.0 -0.1
Ever smoked 0.2 0.3 3.8 0.3 0.0 -0.0 -1.1 0.1 0.0 0.0 1.9 0.5 0.0 0.4 -0.1 0.2 0.4 0.1 -0.3 -0.4 -0.3 0.3 1.3 -0.3 -0.0 -0.2 0.1
Basal metabolic rate 5.4 30.4 72.6 5.8 4.9 5.0 4.0 5.4 -4.5 0.0 -7.2 5.2 4.9 3.8 5.6 7.4 5.8 4.4 3.4 7.2 4.7 4.2 -8.3 8.5 4.7 6.5 4.1
Leg fat percentage (left) 0.0 0.2 2.3 0.0 0.1 0.2 -0.4 0.1 0.1 0.0 -0.3 -0.2 0.1 0.4 0.4 0.4 -0.1 -0.3 -0.2 -0.1 -0.9 -0.4 0.2 0.1 -0.0 -0.0 1.5
Arm fat-free mass (left) 6.2 32.3 80.3 6.0 5.0 5.2 4.2 5.5 -4.7 0.0 -7.1 5.5 5.1 4.0 5.9 7.6 6.0 4.6 3.6 7.5 4.9 4.2 -8.2 9.0 4.9 6.8 3.9
Number of operations (self-reported) 2.5 3.7 12.7 -1.0 -2.0 -2.0 -3.6 -2.1 1.7 0.0 -0.6 -1.8 -2.0 -1.5 -1.0 -0.9 -1.2 -2.1 -2.3 -2.5 -3.2 -2.6 0.1 -1.9 -2.0 -2.2 -1.5
Average weekly beer plus cider intake 1.3 1.8 5.3 0.8 1.6 1.5 1.8 1.4 -1.6 0.0 -0.3 0.1 1.5 1.4 2.0 1.0 0.7 1.4 1.5 1.3 1.4 1.2 0.4 1.3 1.6 1.2 2.3
Irritability 1.6 2.7 5.2 -2.1 -1.8 -1.9 0.1 -1.9 1.8 0.0 -2.2 -1.8 -1.9 -1.7 -0.7 -1.8 -2.3 -1.5 -2.0 -1.2 -1.2 -1.9 -1.9 -1.2 -1.7 -1.6 0.1
Risk taking 0.6 0.9 8.5 0.8 0.8 1.0 -0.2 0.8 -0.6 0.0 0.6 0.9 0.8 1.8 1.2 0.1 0.6 0.4 0.9 0.5 -0.1 0.5 0.8 0.1 0.7 0.2 2.9
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.9 0.1 -0.3 -0.2 -0.2 -0.2 0.2 0.0 -1.4 -0.2 -0.3 -0.4 0.6 0.5 -0.1 -0.6 -0.9 -0.0 -0.6 -0.5 -1.3 0.3 -0.5 -0.4 0.2
Fractured/broken bones in last 5 years 2.4 3.1 4.8 -1.6 -2.0 -1.9 -2.1 -1.9 2.1 0.0 -1.5 -1.4 -2.0 -1.8 -1.5 -1.8 -1.7 -2.2 -1.9 -1.6 -2.1 -1.5 -1.9 -1.4 -2.1 -1.8 -0.9
Age started oral contraceptive pill 0.1 0.2 0.5 -0.3 -0.1 -0.1 0.6 0.0 0.0 0.0 0.7 0.3 -0.1 -0.6 -0.1 -0.4 -0.2 -0.1 0.7 0.3 0.2 0.7 0.6 -0.2 -0.1 0.4 -0.6
Diastolic blood pressure, automated reading 0.4 1.3 6.3 -0.1 -1.0 -1.0 -2.5 -0.9 0.7 0.0 -2.0 -1.4 -1.1 -0.8 -0.1 -0.0 -0.2 -1.3 -1.6 -0.7 -1.4 -1.6 -1.6 -0.3 -1.1 -1.2 -0.6
Ever depressed for a whole week 0.2 0.3 2.2 0.1 0.7 0.8 0.4 0.5 -0.7 0.0 0.6 0.4 0.7 0.6 0.2 0.3 0.2 0.4 0.4 0.1 -0.0 -0.2 1.5 0.1 0.6 0.0 0.5
Unable to work because of sickness or disability 3.2 4.2 8.9 1.8 2.4 2.4 2.0 2.0 -2.1 0.0 1.2 1.7 2.3 3.0 2.2 1.6 1.7 2.2 2.2 1.8 2.4 1.5 2.0 1.6 2.3 2.0 2.9
Commuting to job workplace: Cycle 0.3 0.3 1.2 0.4 0.7 0.9 -0.5 0.5 -0.6 0.0 -1.1 0.2 0.8 0.5 -0.2 0.2 0.5 0.3 0.9 0.7 0.2 0.0 -0.9 0.6 0.7 0.4 0.2
Myopia 0.4 0.6 2.3 0.8 0.7 0.8 -0.3 0.7 -0.6 0.0 1.2 0.6 0.7 1.2 0.3 0.1 0.9 0.6 1.1 -0.0 0.2 0.5 1.2 -0.1 0.7 0.1 1.5
Vascular/heart problems diagnosed by doctor 2.3 6.4 13.2 2.5 2.6 2.6 2.4 2.8 -2.6 0.0 0.5 3.0 2.6 1.6 0.8 2.4 2.7 2.4 3.4 3.6 3.3 3.4 0.2 3.1 2.6 3.4 -0.1
Cholesterol lowering medication 10.3 15.1 31.6 -4.2 -3.7 -3.7 -2.6 -4.0 3.6 0.0 2.5 -4.5 -3.7 -2.9 -3.7 -4.8 -4.3 -3.7 -3.4 -5.0 -4.5 -3.9 3.9 -5.6 -3.7 -5.0 -2.2
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 2.4 -1.1 -1.3 -1.5 -1.0 -1.4 1.1 0.0 -0.8 -1.4 -1.3 -1.2 -0.8 -0.7 -1.2 -1.0 -1.5 -1.1 -1.3 -1.4 -1.0 -0.8 -1.2 -1.1 -0.6
Pain experienced in last month 1.9 3.3 7.2 1.7 1.7 1.6 2.0 1.8 -2.0 0.0 0.8 2.0 1.7 1.1 0.9 1.7 1.8 1.9 2.4 2.7 2.5 2.5 1.1 2.0 1.8 2.2 0.1
Supplements: Calcium 0.6 0.6 3.0 -0.1 -0.2 -0.0 -1.1 -0.3 0.4 0.0 1.7 0.0 -0.2 -0.0 -0.2 -0.6 0.0 -0.6 -0.5 -1.1 -1.6 -0.7 1.6 -1.0 -0.3 -1.0 -0.3
Basal cell carcinoma (self-reported) 0.6 0.7 5.0 -0.7 -0.8 -0.8 -0.5 -0.9 0.5 0.0 -2.2 -1.1 -0.8 -1.0 -0.4 -0.5 -0.6 -0.6 -0.8 -0.3 -0.3 -0.9 -1.6 -0.3 -0.7 -0.1 -0.7
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.8 -1.2 -1.1 -1.1 -1.1 -1.2 1.5 0.0 -0.5 -0.8 -1.1 -0.3 -0.7 -1.5 -1.4 -0.8 -0.8 -1.7 -1.2 -1.4 -0.3 -1.5 -1.1 -1.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.7 0.4 0.2 0.3 0.5 0.3 -0.3 0.0 -0.4 0.7 0.2 -0.0 0.8 0.9 0.3 0.0 -0.6 -0.2 -0.7 -0.1 -1.3 0.7 0.2 -0.0 -0.3
Heart disease (siblings) 1.1 1.3 2.9 -1.5 -0.9 -0.8 -0.7 -1.1 1.1 0.0 0.6 -1.6 -0.9 -0.9 -0.8 -1.6 -1.4 -1.2 -1.1 -1.4 -1.5 -1.2 1.2 -1.7 -0.9 -1.2 -1.0
Alcohol drinker status: Previous 0.4 0.5 5.4 0.1 -0.3 -0.2 -0.2 -0.1 0.4 0.0 2.3 0.9 -0.3 0.1 -0.6 -0.5 -0.0 -0.4 -0.2 -0.9 -0.7 0.4 1.1 -0.9 -0.3 -0.8 0.2
Pack years of smoking 0.2 0.2 0.7 0.5 0.7 0.8 0.3 0.6 -0.5 0.0 0.2 0.5 0.7 0.2 0.3 0.7 0.8 0.5 0.5 0.2 -0.2 0.1 0.2 0.6 0.6 0.4 0.6
Impedance of whole body 3.0 15.8 112.4 -3.1 -1.9 -2.1 -2.2 -2.5 1.5 0.0 9.1 -2.8 -2.0 -0.8 -3.1 -4.9 -3.1 -1.6 -1.0 -4.9 -2.6 -1.8 10.6 -6.4 -1.8 -4.3 -0.0
Leg fat mass (left) 1.2 4.7 10.8 2.3 2.0 2.1 1.4 2.2 -1.8 0.0 -2.6 1.9 2.0 1.8 2.6 3.2 2.2 1.5 1.1 2.6 1.1 1.4 -2.6 3.3 1.8 2.5 2.9
Arm predicted mass (left) 6.2 32.3 79.7 6.1 5.0 5.2 4.1 5.5 -4.7 0.0 -6.9 5.4 5.1 4.0 6.0 7.6 6.1 4.6 3.8 7.5 5.0 4.3 -8.1 8.9 4.9 6.8 4.1