Hub : Genes

AC099850.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.039 0.019 0.0028 0.062 NA 0.026 NA 0.051 7.9e-06 NA 0.003 NA 5.2e-05
2 GTEx Brain Cerebellar Hemisphere 0.136 0.071 0.0078 0.033 NA 0.013 NA 0.033 5.0e-02 NA 0.150 NA 5.0e-02
3 GTEx Esophagus Muscularis 0.055 0.031 0.0099 0.000 NA 0.004 NA 0.002 3.0e-01 NA 0.170 NA 2.5e-01
4 GTEx Whole Blood 0.039 0.019 0.0010 0.042 NA 0.016 NA 0.048 9.8e-05 NA 0.010 NA 3.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.1 0.4 -0.0 0.1 0.4 -0.6
Bipolar Disorder or Schizophrenia 0.6 1.6 3.6 -0.2 1.9 -0.2 -1.6
Depressed Affect (Nagel 2018) 1.2 2.5 5.4 -1.1 2.3 -1.0 -1.5
Depression (Nagel 2018) 0.4 0.6 1.0 1.0 0.5 0.9 0.5
Intelligence (Savage-Jansen 2018) 11.7 35.9 50.8 7.1 -2.3 7.1 6.1
Neuroticism (Nagel 2018) 1.8 4.1 10.6 -0.6 3.3 -1.4 -1.9
Schizophrenia (2018) 1.0 2.2 5.8 -0.3 2.4 -0.6 -1.5
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 -0.3 0.9 0.1 -0.6
Worry (Nagel 2018) 3.1 6.6 9.9 -1.6 3.0 -2.2 -3.1
Alzheimer’s Disease (in mother) 0.1 0.1 0.4 0.1 -0.3 0.0 0.6
Alzheimer’s Disease (in father) 0.1 0.2 0.4 0.0 0.5 0.6 -0.2
Alzheimer’s Disease (including proxy) 0.7 1.0 1.4 -1.2 1.1 -1.1 -0.7
Crohns Disease (2017) 0.6 1.3 4.2 -0.2 2.0 -0.4 -0.9
Irritable Bowel Disease (IBD) 1.3 3.1 8.8 -0.6 3.0 -0.9 -1.6
Ulcerative Colitis (UC) 0.9 1.7 4.8 -0.4 2.2 -0.7 -1.1
Major Depression (MDD) 0.9 1.1 1.6 -1.3 1.0 -0.9 -1.1
Reaction Time 5.7 10.8 16.0 -3.2 2.0 -3.6 -4.0
Verbal and Numeric Reasoning (VNR) 8.5 20.3 32.1 5.7 -0.6 5.4 4.4
Breast Cancer 2.3 5.6 7.5 2.7 -1.8 2.6 2.2
Ovarian Cancer 0.4 0.5 1.1 0.6 -0.1 1.0 0.7
Prostate Cancer 1.9 2.7 8.5 -0.1 -2.9 0.3 1.5
Age at First Birth 1.1 1.7 3.3 1.8 0.1 1.7 0.7
Bipolar Disorder (2011) 2.9 2.8 6.4 -1.1 2.5 -1.4 -1.4
Body Mass Index (BMI) (2010) 0.5 0.6 2.4 0.2 -1.5 0.1 0.4
Coronary Artery Disease (CAD) 0.7 0.8 3.1 -0.1 -1.8 0.4 0.3
Crohns Disease (2012) 0.4 0.7 1.5 0.8 1.2 0.6 -0.4
Mean Putamen Volume 0.1 0.1 0.1 -0.1 0.2 0.3 -0.3
Fasting Glucose 1.4 1.7 3.7 0.9 -0.5 1.9 1.4
HbA1C 0.4 0.4 1.4 0.4 1.2 0.3 -0.3
HDL Cholesterol 0.2 0.3 0.5 -0.5 0.7 -0.7 -0.3
LDL Cholesterol 0.1 0.2 0.4 0.6 0.4 0.2 0.3
Lupus 0.1 0.2 0.6 -0.1 -0.4 -0.8 -0.0
Neuroticism (2016) 1.1 1.5 2.1 -0.6 1.4 -1.4 -1.5
Primary Biliary Cirrhosis 1.2 1.8 3.7 -1.4 0.2 -1.9 -1.2
Rheumatoid Arthritis 2.7 3.7 11.4 0.7 -3.4 0.7 1.6
Schizophrenia (2014) 1.3 2.9 7.6 -0.4 2.7 -0.7 -1.8
Triglycerides 1.0 1.7 2.9 1.7 -0.6 1.5 1.2
Type 2 Diabetes (T2D) (2012) 6.2 7.2 10.0 3.0 -1.6 2.7 3.2
Ulcerative Colitis 3.0 4.4 12.2 -0.9 3.5 -1.3 -1.7
Blood Eosinophil Count 0.3 2.6 3.5 1.9 1.9 1.7 0.9
Blood Platelet Count 0.4 4.7 17.1 -0.3 4.1 -0.5 -1.2
Blood Red Count 0.2 1.9 4.2 0.8 -0.8 1.4 2.0
Blood White Count 0.5 3.5 6.5 -1.7 2.5 -2.0 -0.8
Heel T-Score 0.4 3.0 7.1 1.0 -2.7 1.2 1.6
BMI 0.9 5.3 11.8 1.8 -2.3 0.9 3.4
Height 0.6 11.9 24.3 4.9 0.2 4.4 1.9
Waist Hip Ratio (WHR) 0.1 0.4 0.6 0.7 -0.6 0.6 0.8
Systolic Blood Pressure 2.9 14.5 44.2 1.0 -6.7 1.0 3.4
Smoking Status 0.8 1.9 3.1 1.3 -0.2 1.6 1.8
Allergy or Eczema 0.3 0.8 2.9 0.2 1.7 0.4 -0.2
Cardiovascular Disease 3.5 11.5 18.9 2.2 -4.1 2.4 4.3
Hypothyroidism (self reported) 0.5 1.1 2.1 -0.5 -1.5 -1.4 0.3
Respiratory disease 1.8 4.0 5.6 1.8 -2.0 2.4 1.8
Type 2 Diabetes (T2D) (2018) 3.1 5.8 9.2 1.3 -3.0 2.0 2.9
Lung FEV1/FVC ratio 0.8 4.2 11.2 -0.1 3.3 -1.1 -2.1
Lung FVC 0.1 0.8 1.6 -0.9 -0.0 -1.3 -0.8
Neuroticism 1.6 3.7 7.2 -0.8 2.7 -1.4 -2.3
Chronotype (morning person) 9.9 22.9 30.1 -5.0 3.6 -5.5 -4.9
Hair Pigment 0.4 12.0 17.7 -4.2 2.3 -3.2 -3.9
Tanning 0.3 4.1 6.5 -1.5 2.5 -1.8 -2.1
Hand grip strength (left) 0.3 0.9 1.3 1.2 0.4 1.1 0.8
Number of treatments/medications taken 2.0 3.6 5.8 1.9 -1.8 1.5 2.4
Average weekly spirits intake 1.2 1.5 3.3 1.8 0.1 1.3 1.1
Sensitivity / hurt feelings 4.5 7.7 20.5 -1.1 4.5 -1.6 -2.6
Frequency of depressed mood in last 2 weeks 1.8 2.5 4.0 2.0 -0.5 1.8 1.7
Hearing difficulty/problems: Yes 1.2 1.9 2.8 -1.7 1.2 -1.4 -1.1
Relative age of first facial hair 2.6 5.3 10.6 3.2 0.2 2.6 2.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.0 0.2 1.0 0.4 -0.2
Ever used hormone-replacement therapy (HRT) 1.4 1.8 2.8 -1.4 0.8 -1.7 -1.3
Ever had hysterectomy (womb removed) 0.6 0.7 1.5 -0.9 0.1 -1.2 -0.6
Systolic blood pressure, automated reading 2.0 5.7 21.3 -0.7 -4.6 -0.7 0.7
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.1 0.6 -1.8 0.5 1.3
Angina 0.3 0.4 1.5 0.5 1.2 0.0 -0.0
Medication for hormone replacement therapy 1.6 1.7 3.3 -1.2 1.0 -1.8 -1.1
Vitamin and mineral supplements 0.7 0.9 2.6 -1.0 -1.6 -0.4 0.2
Supplements: Zinc 0.4 0.4 0.6 0.6 0.7 0.8 -0.0
Medication: Co-codamol 2.2 2.6 3.1 -1.3 1.8 -1.5 -1.7
Medication: Metformin 1.8 2.6 4.4 1.1 -2.1 1.3 1.7
Diabetes (father) 1.4 1.7 4.2 -2.1 0.4 -0.8 -1.3
Diabetes (mother) 2.8 3.6 6.0 1.9 -1.4 1.7 2.5
Severe depression (siblings) 2.4 2.7 3.8 1.6 -1.0 1.9 1.9
Pack years adult smoking proportion 0.4 0.7 1.2 1.1 -0.0 0.8 0.9
Impedance of leg (right) 0.3 1.4 2.5 -1.1 1.6 -0.1 -1.4
Leg fat-free mass (left) 1.3 6.6 10.8 3.3 -1.6 2.1 3.0
Trunk fat percentage 1.1 4.3 7.4 2.3 -1.2 1.8 2.7
Hand grip strength (right) 1.5 4.2 5.0 2.1 -1.9 1.9 2.2
Townsend deprivation index at recruitment 0.4 0.5 0.6 0.7 -0.7 0.7 0.8
Current tobacco smoking 0.3 0.5 0.6 0.7 -0.7 0.8 0.6
Average weekly fortified wine intake 0.5 0.6 0.8 0.9 0.4 0.8 0.9
Maternal smoking around birth 0.1 0.2 0.3 0.6 0.4 0.2 0.5
Fed-up feelings 0.9 1.6 2.5 -1.6 1.0 -1.3 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.6 0.1 1.3 0.4 -0.0
Relative age voice broke 0.6 0.9 1.5 0.9 1.2 1.0 0.5
Taking other prescription medications 0.1 0.2 0.9 0.3 0.9 -0.0 0.0
Age when periods started (menarche) 1.7 4.0 6.2 2.5 -0.9 2.4 1.8
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.1 0.5 -1.8 0.4 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.0 -0.2 -0.1 0.2 -0.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.3 0.5 -0.4 -0.9
Qualifications: CSEs or equivalent 4.5 6.0 9.6 -3.1 0.6 -3.1 -2.1
Serious illness, injury or assault to yourself 1.3 1.6 2.3 1.5 0.8 1.4 1.2
High blood pressure 3.1 8.5 13.6 1.9 -3.7 2.0 3.5
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.0 0.2 1.7 0.6 0.1
Multivitamins +/- minerals 0.5 0.6 1.9 0.6 1.4 0.4 -0.2
Stomach or abdominal pain in last month 1.8 2.2 6.5 -0.5 2.6 -1.0 -1.1
Supplements: Glucosamine 2.0 2.7 4.9 2.0 1.2 2.2 0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.4 -0.2 -0.3 0.3
Medication: Atenolol 1.2 1.5 3.0 1.6 0.3 0.7 1.7
Medication: Levothyroxine sodium 0.5 0.9 2.3 0.7 -1.5 -0.2 0.9
Sitting height 1.9 13.8 20.2 4.5 -2.0 4.1 3.8
Chronic bronchitis/emphysema (father) 0.8 0.9 2.9 0.2 -1.7 0.3 0.8
High blood pressure (mother) 0.2 0.3 1.1 -0.3 0.2 -1.0 0.1
Body mass index (BMI) 0.6 2.5 6.1 1.3 -1.4 0.5 2.5
Impedance of leg (left) 0.3 1.4 2.9 -0.9 1.7 0.3 -1.4
Leg predicted mass (left) 1.2 6.5 10.5 3.2 -1.6 2.0 3.0
Trunk fat mass 1.1 4.9 8.2 2.6 -1.2 1.8 2.9
Waist circumference 2.3 8.3 13.1 3.0 -2.3 2.4 3.6
Number of incorrect matches in round 0.2 0.4 0.9 0.5 -0.6 1.0 -0.4
Past tobacco smoking 0.6 1.2 2.4 -0.8 0.2 -1.3 -1.5
Alcohol usually taken with meals 0.3 0.5 0.8 0.5 -0.7 0.8 0.9
Nervous feelings 0.4 0.8 1.5 -0.0 0.9 -1.0 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 0.7 -0.4 0.3 1.1
Hearing difficulty/problems with background noise 1.2 1.8 4.3 -0.5 2.1 -0.8 -1.5
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 -0.3 -0.4 -0.6 0.2
Had menopause 0.7 0.9 2.9 0.5 -1.7 0.5 0.6
Had other major operations 6.7 8.2 10.1 2.8 -2.7 2.7 3.2
Forced vital capacity (FVC) 0.2 0.8 2.0 1.4 0.4 0.8 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.4 0.1 -0.4 -0.2
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 4.0 2.0 -0.4 1.9 1.7
Qualifications: None of the above 0.3 0.7 1.3 -1.1 -0.2 -1.1 -0.5
Financial difficulties in last 2 years 1.3 1.8 3.9 1.1 2.0 1.3 0.7
Mouth/teeth dental problems 1.3 2.0 3.2 1.2 -1.1 1.5 1.8
Heart attack 0.8 1.0 3.4 0.5 1.8 -0.5 0.0
Allergy 0.3 0.7 1.6 -0.6 0.1 -1.2 -1.0
Pain all over the body in last month 0.1 0.1 0.2 -0.5 0.3 -0.2 0.3
Diabetes (self-reported) 3.2 5.0 7.4 1.6 -2.7 1.8 2.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.0 -0.0 1.0 -0.0 -0.1
Medication: Ramipril 3.4 4.4 8.7 1.6 -2.9 1.4 2.1
Medication: Simvastatin 1.4 2.0 3.5 1.2 -1.6 0.8 1.9
Fluid intelligence score 9.9 20.5 31.6 5.3 -1.6 5.6 4.5
Illnesses of siblings 1.3 1.8 4.0 -1.3 0.7 -1.0 -2.0
Neuroticism score 1.3 2.7 7.1 -0.3 2.7 -0.8 -1.8
Weight 1.5 7.2 11.3 3.1 -1.7 2.2 3.4
Impedance of arm (right) 0.2 1.1 2.0 -0.1 1.4 0.7 -1.4
Arm fat percentage (right) 0.4 1.5 3.5 1.2 -0.9 0.5 1.9
Trunk fat-free mass 0.8 4.4 7.1 2.7 -1.5 1.6 2.4
Hip circumference 2.0 8.7 12.4 3.3 -2.0 2.8 3.5
Time employed in main current job 0.2 0.2 0.7 0.2 -0.1 -0.8 0.2
Alcohol intake versus 10 years previously 0.4 0.6 2.0 -0.7 1.4 -0.2 -0.3
Father’s age at death 0.2 0.2 0.6 0.5 0.8 0.1 0.2
Worrier / anxious feelings 1.4 2.7 6.8 -0.3 2.6 -0.8 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.2 -0.1 0.1 -0.7 1.1
Falls in the last year 4.1 5.6 7.5 2.4 -2.0 2.2 2.7
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 0.6 0.8 0.2 -0.3
Number of live births 1.0 1.3 2.4 0.7 -1.3 0.9 1.6
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.7 1.1 1.6 0.2 -0.1
Pulse rate 1.6 2.7 6.0 -1.9 -0.2 -2.4 -1.1
Happiness 0.1 0.1 0.1 0.1 -0.3 0.1 0.4
Noisy workplace 1.6 2.0 3.5 -1.4 0.4 -1.9 -1.5
Qualifications: A levels/AS levels or equivalent 2.6 5.7 10.7 3.3 0.7 2.6 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.4 0.7 0.6 0.3 1.2
Mouth/teeth dental problems: Dentures 1.4 2.3 3.6 -1.5 0.8 -1.7 -1.9
Asthma 1.9 3.8 5.5 1.6 -2.4 2.0 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 0.1 0.6 0.3 0.5
Medication: Cholesterol lowering 0.3 0.4 0.9 0.6 0.3 0.6 1.0
Depression (self-reported) 1.8 2.1 4.3 -0.8 2.1 -1.1 -1.5
Medication: Lansoprazole 0.2 0.2 0.8 -0.3 -0.9 -0.4 -0.1
Prospective memory result 3.7 4.6 8.1 -2.8 -0.1 -2.0 -2.4
Lung cancer (father) 2.2 2.6 4.0 1.3 -2.0 1.4 1.6
Illnesses of mother 0.8 1.0 1.8 -0.8 1.1 -0.7 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.2 1.5 0.9 0.4 0.6
Pulse wave Arterial Stiffness index 0.8 0.9 1.9 -0.8 0.5 -1.4 -0.9
Impedance of arm (left) 0.2 0.7 1.6 0.4 0.7 1.3 -0.8
Arm fat mass (right) 0.6 2.4 5.2 1.7 -1.1 0.7 2.3
Trunk predicted mass 0.6 3.7 6.4 2.5 -1.3 1.4 2.2
Standing height 0.9 8.8 17.0 4.1 -0.9 3.5 2.2
Length of working week for main job 0.8 0.9 1.2 1.1 1.0 1.0 0.8
Exposure to tobacco smoke at home 0.5 0.6 1.3 0.1 -1.0 0.1 1.1
Breastfed as a baby 0.6 0.7 2.2 0.2 -1.5 0.7 0.3
Tense / ‘highly strung’ 3.3 5.5 8.1 -2.2 2.0 -2.3 -2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.2 1.2 1.8 0.4 -0.0
Hair/balding pattern: Pattern 4 1.1 2.6 4.1 2.0 -1.2 1.9 1.2
Birth weight of first child 0.6 1.1 2.4 1.6 1.2 0.8 -0.2
Peak expiratory flow (PEF) 0.6 1.3 3.4 1.2 1.8 0.5 0.2
Pulse wave reflection index 0.9 1.1 1.5 -0.7 1.0 -1.2 -1.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 -0.4 0.2 -0.2 -0.3
Loud music exposure frequency 1.1 1.2 1.9 -1.3 0.2 -1.4 -1.2
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 4.3 1.9 0.9 2.1 1.3
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.2 1.4 -0.9 0.9 1.8
Blood clot in the leg (DVT) 0.5 0.7 1.0 0.3 -1.0 0.8 0.9
Medication: Paracetamol 0.0 0.0 0.1 -0.1 0.2 0.2 0.0
Headache pain in last month 5.5 9.5 10.0 -3.0 3.1 -3.2 -3.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 3.0 -0.6 1.3 -0.9 -1.7
Glaucoma (self-reported) 1.4 1.7 2.3 -1.5 0.5 -1.5 -1.4
Gout (self-reported) 0.5 0.7 2.6 -0.0 -1.6 0.3 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.1 0.3 -1.0 -0.3 0.5
Medication: Amlodipine 14.1 19.8 28.3 4.0 -4.2 4.1 5.3
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.6 0.3 -0.8 0.7 0.2
Birth weight 2.4 5.3 9.7 -1.4 3.1 -1.7 -2.6
Chronic bronchitis/emphysema (mother) 2.0 2.3 3.0 -1.4 1.3 -1.6 -1.7
High blood pressure (siblings) 0.3 0.5 1.1 0.9 -0.1 0.1 1.1
Forced vital capacity (FVC), Best measure 0.6 2.2 4.4 2.1 -0.4 1.4 1.5
Body fat percentage 0.8 3.3 6.5 1.9 -1.0 1.4 2.5
Leg fat percentage (right) 0.3 1.1 3.1 0.7 -0.8 0.4 1.8
Arm fat-free mass (right) 1.1 5.9 8.8 3.0 -1.5 2.0 2.9
Exposure to tobacco smoke outside home 0.5 0.6 1.7 -0.8 -0.2 -1.3 0.0
Comparative body size at age 10 0.6 1.5 2.2 -1.1 1.5 -1.1 -1.2
Number of full brothers 0.2 0.2 0.7 0.0 -0.4 0.2 0.8
Worry too long after embarrassment 0.5 0.8 2.0 1.4 0.5 0.7 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.7 0.0 1.3 -0.2 -1.1
Wheeze or whistling in the chest in last year 1.4 2.4 5.7 0.3 -2.4 0.6 1.9
Number of children fathered 0.1 0.1 0.4 0.4 0.6 -0.2 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.2 -0.8 1.1 -0.9 -0.8
Age at first live birth 1.4 2.4 4.7 2.2 -0.7 2.0 0.8
Pulse wave peak to peak time 1.1 1.4 2.9 1.2 -0.4 1.7 1.0
Health satisfaction 0.2 0.3 0.6 0.1 0.2 0.6 0.8
Shortness of breath walking on level ground 0.3 0.4 0.6 -0.6 0.8 -0.7 -0.5
Qualifications: College or University degree 1.9 5.9 10.5 3.2 -0.5 3.2 1.7
Eye problems/disorders: None of the above 0.0 0.0 0.1 -0.2 -0.2 -0.1 -0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.7 0.7 -0.8 0.4 0.1
Emphysema/chronic bronchitis 1.2 1.4 2.0 0.8 -1.3 1.1 1.4
Medication for pain relief, constipation, heartburn 0.4 0.6 1.0 -0.8 -0.3 -0.8 -1.0
Neck or shoulder pain in last month 1.9 2.7 3.7 -1.7 1.9 -1.4 -1.4
Medication: Blood pressure 2.4 4.3 8.0 1.6 -1.8 1.8 2.8
Angina (self-reported) 0.3 0.4 1.5 0.2 1.2 -0.2 -0.3
Migraine (self-reported) 0.2 0.3 0.5 -0.6 -0.7 -0.3 0.3
Medication: Ibuprofen 0.1 0.1 0.1 -0.1 0.3 -0.0 0.4
Medication: Allopurinol 0.2 0.3 0.7 0.3 -0.8 0.6 0.3
Medication: Omeprazole 0.4 0.5 0.8 -0.6 0.9 -0.8 -0.3
Medication: Seretide 50 evohaler 3.0 3.5 4.4 2.1 -1.5 1.9 1.9
Mean time to correctly identify matches 5.3 10.1 15.8 -3.4 1.4 -3.3 -4.0
Heart disease (mother) 1.1 1.4 1.9 1.1 -0.7 1.3 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.7 -0.6 -0.8 0.3 0.3
Whole body fat mass 1.0 4.2 7.4 2.4 -1.1 1.6 2.7
Leg fat mass (right) 0.8 2.9 6.1 1.8 -1.1 1.0 2.5
Arm predicted mass (right) 1.1 5.6 8.5 2.9 -1.5 1.8 2.9
Pulse rate, automated reading 0.5 1.7 5.8 -0.1 -2.4 -0.6 0.8
Alcohol intake frequency. 1.7 4.0 5.9 -2.0 1.8 -1.7 -2.4
Comparative height size at age 10 0.2 0.9 1.4 -0.7 0.6 -1.1 -1.2
Number of full sisters 3.0 3.6 6.2 1.5 -1.9 1.5 2.5
Suffer from ‘nerves’ 2.4 3.7 6.3 -1.2 2.2 -1.6 -2.5
Overall health rating 0.6 1.3 3.4 0.7 -0.3 1.1 1.9
Chest pain or discomfort 4.4 6.4 8.6 2.9 -1.0 2.8 2.9
Had major operations 4.2 4.9 5.8 -2.0 2.4 -2.4 -2.0
Age at last live birth 2.1 3.0 5.5 2.3 -0.8 1.8 1.6
Family relationship satisfaction 0.8 1.0 3.6 -0.1 1.9 -0.2 -0.7
Leg pain on walking 0.1 0.1 0.3 -0.3 -0.1 -0.1 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 3.2 -1.8 1.7 -1.3 -1.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.8 -0.6 0.5 -0.9 0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.2 -0.7 -0.9 -0.7 -1.1
Medication: Aspirin 6.4 8.4 10.6 3.3 -2.0 3.1 3.1
Supplements: Vitamin C 0.9 1.0 2.5 1.6 -0.3 1.0 0.8
Knee pain experienced in last month 1.4 2.1 3.5 1.4 -0.7 1.9 1.6
Hypertension (Self-reported) 2.6 7.3 11.7 1.8 -3.4 1.7 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.8 1.4 1.2 -1.0 0.3 0.8
Illnesses of father: Heart disease 0.1 0.2 0.6 0.0 -0.2 0.2 0.8
Illnesses of siblings: Diabetes 0.1 0.2 0.4 -0.4 0.7 0.4 -0.1
Smoking status: Previous 0.1 0.1 0.2 -0.4 0.3 -0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 3.9 2.0 -1.1 1.6 1.9
Whole body fat-free mass 1.0 5.8 9.5 3.1 -1.5 1.9 2.8
Leg fat-free mass (right) 1.3 6.7 11.3 3.4 -1.5 2.2 2.9
Arm fat percentage (left) 0.5 2.0 4.4 1.5 -0.9 0.8 2.1
Average weekly red wine intake 2.4 3.5 6.0 2.5 -1.4 1.9 1.6
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 -1.1 -0.1 -0.7 -0.5
Mood swings 0.1 0.3 0.4 -0.5 0.7 -0.4 -0.4
Loneliness, isolation 2.9 4.0 13.2 -0.2 3.6 0.1 -1.7
Long-standing illness, disability or infirmity 0.6 1.0 1.7 0.8 0.1 1.3 1.2
Ever had bowel cancer screening 0.6 0.7 1.9 1.4 0.5 0.8 -0.0
Diabetes diagnosed by doctor 2.3 3.7 6.9 1.0 -2.6 1.5 2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 -0.3 1.2 -0.3 -0.2
Friendships satisfaction 6.6 8.2 10.4 -2.7 3.1 -2.3 -3.2
Qualifications: nursing, teaching 2.0 3.1 5.3 2.2 0.4 2.3 1.5
Commuting to job workplace: Walk 0.9 1.0 2.1 0.8 -1.4 0.3 1.1
Eye problems/disorders: Cataract 0.5 0.5 1.5 0.6 1.2 0.5 0.2
Mouth/teeth dental problems: Mouth ulcers 2.7 4.2 6.8 -2.3 1.2 -1.9 -2.6
Medication for cholesterol 4.1 6.2 8.0 -2.6 2.2 -2.3 -2.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.5 1.2 0.4 0.4 0.4
Back pain experienced in last month 0.4 0.5 2.0 0.2 1.4 -0.2 0.3
Mineral and other dietary supplements 0.9 1.2 2.2 -1.5 -0.1 -1.4 -0.6
Breast cancer (self-reported) 0.1 0.1 0.3 0.1 0.5 0.2 -0.0
Asthma (self-reported) 2.4 4.7 6.8 1.7 -2.6 2.3 2.0
Osteoporosis (self-reported) 0.6 0.7 1.2 -0.7 1.0 -0.5 -1.1
Osteoarthritis (self-reported) 0.4 0.5 1.0 0.9 0.2 1.0 -0.1
Medication: Aspirin 6.6 8.7 10.2 3.2 -2.4 2.9 3.2
Medication: Gliclazide 1.2 1.4 2.3 1.1 -1.4 0.3 1.5
Illnesses of father: None of the above (group 1) 0.3 0.3 0.7 0.2 0.7 -0.4 -0.8
Smoking status: Current 0.4 0.6 1.0 0.8 -0.6 1.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 0.1 0.4 -0.6 -0.2
Whole body water mass 1.0 5.6 9.2 3.0 -1.5 1.8 2.8
Leg predicted mass (right) 1.2 6.6 11.2 3.4 -1.4 2.2 2.9
Arm fat mass (left) 0.6 2.6 5.3 1.9 -1.0 0.9 2.3
Number of self-reported non-cancer illnesses 1.2 2.2 4.5 1.2 -1.1 1.2 2.1
Average weekly champagne plus white wine intake 0.9 1.3 2.5 1.0 -0.6 1.1 1.6
Miserableness 0.1 0.2 0.5 0.3 0.7 -0.3 -0.1
Guilty feelings 0.4 0.6 0.9 0.9 0.7 1.0 0.1
Wears glasses or contact lenses 0.3 0.3 0.5 0.4 -0.6 0.7 0.5
Ever taken oral contraceptive pill 0.7 0.7 1.1 0.5 -1.0 1.0 0.8
Hearing aid user 0.7 0.8 1.2 -1.1 -0.6 -0.9 -1.0
Mother’s age at death 0.2 0.3 0.6 0.7 -0.3 0.5 0.4
Financial situation satisfaction 6.6 8.2 10.7 -2.7 3.3 -2.8 -2.6
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.1 0.4 -0.1 1.0 0.9
Commuting to job workplace: Public transport 1.1 1.3 2.1 1.4 -0.5 1.4 1.0
Eye problems/disorders: Glaucoma 1.3 1.6 2.5 -1.6 0.5 -1.2 -1.4
Medication: Blood pressure 3.8 7.2 10.2 2.5 -2.8 2.1 3.2
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.8 0.5 1.0 1.3 0.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.7 0.5 0.6 0.8 -0.3
High cholesterol (Self-reported) 1.5 2.6 4.9 0.8 -2.2 1.1 2.0
Medication: Bendroflumethiazide 0.9 1.3 2.7 0.6 -1.4 0.6 1.6
Medication: Paracetamol 0.0 0.1 0.2 0.1 0.1 0.4 0.2
Medication: Lisinopril 0.8 1.0 2.0 1.2 -0.5 0.6 1.4
Medication: Atorvastatin 3.6 4.4 6.6 1.8 -2.2 1.8 2.6
Illnesses of father: High blood pressure 0.0 0.1 0.1 -0.3 -0.2 -0.3 -0.0
Alcohol drinker status: Never 0.2 0.2 0.6 0.0 -0.8 0.4 -0.5
Ever smoked 1.5 2.7 4.5 1.5 -0.7 1.9 2.1
Basal metabolic rate 1.2 6.6 10.4 3.2 -1.6 2.0 3.1
Leg fat percentage (left) 0.3 1.2 3.5 0.8 -0.7 0.5 1.9
Arm fat-free mass (left) 0.7 3.5 5.6 2.3 -1.2 1.2 2.4
Number of operations (self-reported) 0.1 0.2 0.5 -0.4 0.3 -0.7 0.0
Average weekly beer plus cider intake 3.6 5.2 6.0 2.2 -2.4 2.1 2.5
Irritability 0.3 0.5 1.2 1.1 0.7 0.5 0.4
Risk taking 0.1 0.1 0.3 -0.3 0.5 -0.3 -0.2
Ever had prostate specific antigen (PSA) test 2.0 2.3 3.9 -1.1 1.4 -1.5 -2.0
Fractured/broken bones in last 5 years 0.3 0.4 0.9 0.7 0.1 1.0 0.5
Age started oral contraceptive pill 1.5 1.9 4.1 2.0 -1.1 1.3 0.8
Diastolic blood pressure, automated reading 2.8 8.6 26.3 1.0 -5.1 1.0 2.5
Ever depressed for a whole week 3.7 4.6 6.8 2.6 -0.4 2.4 2.3
Unable to work because of sickness or disability 0.9 1.2 2.2 1.5 -0.3 1.4 0.7
Commuting to job workplace: Cycle 0.1 0.1 0.2 0.2 0.3 0.2 -0.5
Myopia 6.2 9.1 15.8 2.2 -4.0 2.1 3.3
Vascular/heart problems diagnosed by doctor 2.5 6.8 11.3 -1.5 3.4 -1.5 -3.3
Cholesterol lowering medication 4.5 6.6 8.0 2.4 -2.8 2.3 2.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.8 0.0 0.9 0.2 -0.0
Pain experienced in last month 0.9 1.5 5.2 0.6 -2.3 0.0 0.7
Supplements: Calcium 0.7 0.8 1.7 1.2 1.3 0.2 0.3
Basal cell carcinoma (self-reported) 0.4 0.4 1.3 -0.3 -1.1 -0.6 0.0
Heart attack/myocardial infarction (self-reported) 0.9 1.1 3.8 0.5 1.9 -0.6 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 0.1 -1.0 0.6 0.8
Heart disease (siblings) 0.1 0.2 0.4 0.3 0.4 0.2 0.7
Alcohol drinker status: Previous 0.4 0.5 1.1 -0.1 0.9 -0.1 -1.0
Pack years of smoking 0.5 0.8 1.4 1.2 -0.4 1.0 0.9
Impedance of whole body 0.2 1.0 1.9 -0.4 1.4 0.6 -1.2
Leg fat mass (left) 0.7 2.9 6.2 1.8 -0.9 1.1 2.5
Arm predicted mass (left) 1.0 4.9 7.8 2.8 -1.2 1.6 2.8