Hub : Genes

AC144652.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.251 0.0770 9.6e-04 0.006 NA 0.013 NA -0.002 1.0e-01 NA 3.3e-02 NA 5.6e-01
2 GTEx Testis 0.229 0.0780 9.3e-03 0.252 NA 0.207 NA 0.038 1.4e-11 NA 1.4e-09 NA 8.4e-03
3 METSIM Adipose 0.163 0.0366 2.8e-07 0.058 0.048 0.072 0.087 0.089 4.7e-09 9.2e-08 6.6e-11 5.1e-13 2.7e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.3 0.4 0.4 0.6 -0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.4 -0.3 -0.2 -0.6
Depressed Affect (Nagel 2018) 4.4 9.3 16.2 -1.4 -4.0 3.1
Depression (Nagel 2018) 1.7 2.5 4.1 -1.8 -2.0 0.5
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.2 0.5 1.1 -0.7
Neuroticism (Nagel 2018) 3.8 9.0 18.0 -1.7 -4.2 2.5
Schizophrenia (2018) 0.2 0.4 0.7 -0.5 -0.8 -0.4
Schizophrenia vs Biploar Disorder 1.7 2.2 3.8 -1.9 -1.1 1.2
Worry (Nagel 2018) 3.1 6.5 14.6 -1.1 -3.8 1.9
Alzheimer’s Disease (in mother) 1.6 1.9 2.7 1.6 1.0 -1.4
Alzheimer’s Disease (in father) 0.7 0.8 1.6 1.2 -0.6 0.7
Alzheimer’s Disease (including proxy) 1.9 2.7 4.5 2.1 1.0 -1.6
Crohns Disease (2017) 0.3 0.6 1.1 -1.1 -0.7 0.5
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 0.1 -0.1 1.1
Ulcerative Colitis (UC) 0.4 0.7 2.0 0.1 0.3 1.4
Major Depression (MDD) 0.9 1.1 2.2 -0.3 -1.0 1.5
Reaction Time 0.7 1.3 2.0 1.4 1.4 -0.0
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.0 1.4 0.9 -0.5
Breast Cancer 0.2 0.5 1.3 0.2 0.0 -1.2
Ovarian Cancer 0.3 0.5 1.4 0.0 -1.2 -0.0
Prostate Cancer 0.3 0.5 1.2 1.1 0.5 -0.1
Age at First Birth 0.4 0.6 1.0 0.8 0.1 1.0
Bipolar Disorder (2011) 0.4 0.4 1.1 0.0 0.0 -1.1
Body Mass Index (BMI) (2010) 0.3 0.5 0.7 0.6 0.6 0.8
Coronary Artery Disease (CAD) 1.5 1.8 3.7 0.3 -1.3 1.9
Crohns Disease (2012) 0.4 0.6 1.3 -0.5 0.5 -1.1
Mean Putamen Volume 0.4 0.4 0.8 -0.9 0.3 -0.7
Fasting Glucose 0.3 0.4 0.9 -0.4 0.9 0.4
HbA1C 0.7 0.8 1.6 0.5 1.3 -0.8
HDL Cholesterol 0.5 0.8 2.1 1.5 -0.0 -0.5
LDL Cholesterol 2.1 3.3 5.5 -1.7 -2.3 1.2
Lupus 0.6 0.9 2.5 -1.6 0.2 0.5
Neuroticism (2016) 3.3 4.8 10.2 -1.7 -3.2 1.1
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.3 0.4 -0.1
Rheumatoid Arthritis 0.9 1.2 3.0 -1.7 -0.6 -0.4
Schizophrenia (2014) 0.2 0.4 1.1 -0.4 -1.0 -0.0
Triglycerides 0.4 0.7 1.4 0.3 -0.7 1.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.9 -1.4 -0.5 -0.1
Ulcerative Colitis 0.5 0.8 1.1 1.0 1.1 -0.3
Blood Eosinophil Count 0.1 0.9 1.6 -1.3 -0.5 -0.9
Blood Platelet Count 0.9 10.7 24.0 -2.8 -4.9 0.7
Blood Red Count 0.1 0.8 2.2 0.4 1.5 -0.1
Blood White Count 0.1 0.5 0.9 0.0 0.7 -1.0
Heel T-Score 0.0 0.2 0.3 -0.3 0.5 -0.5
BMI 0.0 0.2 0.5 0.7 -0.5 0.0
Height 0.3 5.7 9.3 0.4 3.0 -2.8
Waist Hip Ratio (WHR) 0.5 2.1 3.1 0.3 -1.7 1.8
Systolic Blood Pressure 0.6 2.8 3.4 1.7 -1.5 1.9
Smoking Status 0.3 0.6 1.2 0.7 0.4 1.1
Allergy or Eczema 0.0 0.1 0.1 0.3 -0.0 -0.3
Cardiovascular Disease 1.5 5.0 8.4 1.0 -2.9 2.4
Hypothyroidism (self reported) 1.0 2.2 4.5 -0.9 -2.1 1.1
Respiratory disease 0.4 0.9 1.3 -1.1 -1.1 -0.2
Type 2 Diabetes (T2D) (2018) 1.7 3.2 4.8 -0.1 -2.2 2.2
Lung FEV1/FVC ratio 1.0 4.9 7.6 -2.4 -2.8 1.2
Lung FVC 0.3 1.4 2.5 -1.1 1.6 -0.8
Neuroticism 6.0 14.4 31.8 -2.3 -5.6 2.5
Chronotype (morning person) 0.1 0.3 0.5 -0.2 0.7 -0.6
Hair Pigment 0.3 7.6 15.8 -2.5 -4.0 0.8
Tanning 0.0 0.3 0.6 0.7 -0.5 0.5
Hand grip strength (left) 0.3 0.9 1.9 -1.4 -0.6 -0.5
Number of treatments/medications taken 1.8 3.3 7.1 -0.7 -2.7 1.5
Average weekly spirits intake 1.2 1.4 3.6 -0.8 -1.9 -0.2
Sensitivity / hurt feelings 1.4 2.4 7.0 -0.2 -2.6 0.6
Frequency of depressed mood in last 2 weeks 1.1 1.6 3.0 -1.3 -1.7 -0.1
Hearing difficulty/problems: Yes 0.5 0.8 2.3 0.1 0.2 -1.5
Relative age of first facial hair 0.3 0.7 1.1 -0.1 0.9 -1.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.1 0.4 0.2
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 0.0 0.0 0.1
Ever had hysterectomy (womb removed) 1.6 1.8 5.2 -2.3 -0.3 0.1
Systolic blood pressure, automated reading 0.4 1.3 2.4 1.5 -0.7 1.0
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 2.7 0.1 -1.4 1.6
Angina 1.0 1.3 3.5 0.6 0.1 1.9
Medication for hormone replacement therapy 0.3 0.4 0.9 -0.4 -1.0 0.3
Vitamin and mineral supplements 0.3 0.4 0.7 -0.7 -0.8 0.2
Supplements: Zinc 0.8 0.8 2.1 -0.4 -0.4 1.5
Medication: Co-codamol 0.4 0.4 0.7 -0.9 -0.7 -0.2
Medication: Metformin 0.6 0.8 1.7 0.3 -1.3 0.9
Diabetes (father) 4.5 5.6 8.5 0.0 -2.9 2.9
Diabetes (mother) 0.5 0.7 1.5 -0.6 -0.4 1.2
Severe depression (siblings) 0.5 0.6 1.4 0.4 -1.2 -0.4
Pack years adult smoking proportion 0.5 0.8 1.6 1.2 -0.5 -0.8
Impedance of leg (right) 0.2 0.9 1.2 -1.1 -1.1 0.7
Leg fat-free mass (left) 0.2 1.1 1.7 -0.5 1.2 -1.3
Trunk fat percentage 0.2 0.8 1.8 -0.8 -1.3 -0.2
Hand grip strength (right) 0.2 0.4 0.7 -0.9 -0.1 -0.7
Townsend deprivation index at recruitment 0.8 1.2 2.1 1.0 0.5 -1.5
Current tobacco smoking 0.7 1.2 3.0 1.7 0.7 0.1
Average weekly fortified wine intake 0.7 0.8 2.1 0.4 0.2 -1.5
Maternal smoking around birth 0.2 0.3 0.7 0.1 -0.5 0.8
Fed-up feelings 5.2 9.5 16.7 -1.5 -4.1 3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.3 6.8 -2.4 -2.6 0.3
Relative age voice broke 0.2 0.2 0.7 0.8 0.2 0.2
Taking other prescription medications 2.1 3.3 6.2 -1.7 -2.5 0.9
Age when periods started (menarche) 0.1 0.2 0.4 -0.6 -0.2 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.4 -0.6 -0.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.1 -1.0 1.0 -1.0
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.3 0.4 -0.6 -0.1
Qualifications: CSEs or equivalent 1.9 2.6 7.3 -2.7 -0.5 -0.4
Serious illness, injury or assault to yourself 0.3 0.3 0.8 -0.9 -0.5 0.1
High blood pressure 0.7 2.0 3.6 1.0 -1.9 1.1
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.1 -0.1 -0.4 -0.1
Multivitamins +/- minerals 0.4 0.5 1.3 0.4 1.2 -0.2
Stomach or abdominal pain in last month 1.4 1.7 5.1 0.2 -2.2 -0.3
Supplements: Glucosamine 0.4 0.5 0.8 -0.9 0.7 -0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 2.1 1.5 0.3 0.2
Medication: Atenolol 0.8 1.0 1.6 -0.5 -1.3 1.1
Medication: Levothyroxine sodium 0.3 0.5 1.1 1.1 -0.5 0.4
Sitting height 0.5 3.6 5.0 -1.6 2.2 -1.8
Chronic bronchitis/emphysema (father) 0.8 0.9 2.5 1.6 -0.4 0.2
High blood pressure (mother) 1.3 1.9 3.4 -1.5 -1.9 0.3
Body mass index (BMI) 0.1 0.2 0.6 0.1 -0.8 -0.2
Impedance of leg (left) 0.3 1.3 2.7 -0.8 -1.6 0.8
Leg predicted mass (left) 0.2 0.9 1.3 -0.5 1.0 -1.1
Trunk fat mass 0.1 0.6 0.7 -0.8 -0.7 -0.7
Waist circumference 0.1 0.3 0.5 0.5 0.0 -0.7
Number of incorrect matches in round 0.3 0.5 1.1 -0.2 0.5 -1.0
Past tobacco smoking 0.1 0.2 0.4 0.2 -0.6 -0.1
Alcohol usually taken with meals 1.8 2.9 8.0 0.5 2.8 -0.6
Nervous feelings 2.2 4.1 10.4 -0.7 -3.2 1.2
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.0 8.1 -1.2 -2.9 1.5
Hearing difficulty/problems with background noise 0.7 1.1 3.1 0.4 0.2 -1.8
Hair/balding pattern: Pattern 2 0.3 0.3 0.9 0.9 0.3 0.1
Had menopause 0.9 1.1 1.8 1.2 1.3 -0.4
Had other major operations 1.0 1.3 1.5 -1.2 -1.1 -1.1
Forced vital capacity (FVC) 0.3 1.2 2.3 -1.5 1.1 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 1.6 -1.1 1.2 -1.1
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 2.6 -1.6 -0.2 -1.6
Qualifications: None of the above 1.5 3.2 5.9 0.0 -2.4 1.9
Financial difficulties in last 2 years 0.0 0.0 0.0 0.1 -0.1 -0.1
Mouth/teeth dental problems 0.8 1.2 1.6 -1.2 1.0 -1.1
Heart attack 0.8 1.0 2.3 0.3 0.7 -1.5
Allergy 0.2 0.3 0.7 0.6 0.8 0.0
Pain all over the body in last month 0.2 0.2 0.5 -0.3 0.2 0.7
Diabetes (self-reported) 2.0 3.1 4.1 1.6 -1.6 2.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.6 -1.3 -0.1 -0.9
Medication: Ramipril 1.0 1.3 2.8 0.6 0.8 -1.7
Medication: Simvastatin 1.9 2.8 5.1 -0.1 -2.2 1.8
Fluid intelligence score 1.4 2.9 5.1 2.3 1.7 -0.8
Illnesses of siblings 0.1 0.1 0.2 0.4 0.5 -0.0
Neuroticism score 6.7 14.0 28.7 -2.3 -5.4 2.9
Weight 0.1 0.6 1.5 -0.4 0.4 -1.2
Impedance of arm (right) 0.0 0.1 0.1 0.2 -0.3 -0.3
Arm fat percentage (right) 0.2 0.7 1.9 -0.3 -1.4 0.1
Trunk fat-free mass 0.4 2.1 3.8 -0.9 1.9 -1.4
Hip circumference 0.3 1.5 2.8 0.1 1.3 -1.7
Time employed in main current job 0.1 0.1 0.3 0.3 -0.0 -0.5
Alcohol intake versus 10 years previously 0.4 0.6 0.9 -0.5 -1.0 0.9
Father’s age at death 0.4 0.5 0.8 -0.4 -0.8 -0.9
Worrier / anxious feelings 3.0 5.7 11.2 -2.3 -3.3 0.9
Frequency of tiredness / lethargy in last 2 weeks 6.5 10.6 18.7 -2.9 -4.3 2.1
Falls in the last year 0.3 0.4 0.8 -0.5 -0.9 0.3
Hair/balding pattern: Pattern 3 0.5 0.8 2.3 0.3 -0.3 1.5
Number of live births 0.3 0.4 0.9 -0.6 -0.9 -0.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 7.4 -2.7 -0.4 0.9
Pulse rate 0.5 0.9 2.2 -1.5 -0.6 -0.4
Happiness 0.5 0.6 1.6 -0.1 -1.3 -0.0
Noisy workplace 0.2 0.3 0.7 -0.9 -0.4 0.1
Qualifications: A levels/AS levels or equivalent 0.8 1.8 2.7 -0.3 1.6 -1.6
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 4.4 0.3 -2.1 0.9
Mouth/teeth dental problems: Dentures 0.3 0.4 1.0 0.6 0.1 1.0
Asthma 0.2 0.4 0.6 -0.7 -0.8 -0.5
Medication: Ibuprofen (e.g. Nurofen) 3.1 4.0 7.5 2.7 1.6 -1.4
Medication: Cholesterol lowering 2.8 4.4 8.3 -0.8 -2.9 2.0
Depression (self-reported) 1.5 1.8 3.1 -1.8 -0.6 -1.3
Medication: Lansoprazole 0.5 0.5 1.3 1.1 -0.5 0.3
Prospective memory result 0.3 0.4 0.5 -0.6 -0.7 -0.4
Lung cancer (father) 0.4 0.5 0.8 0.2 -0.7 0.9
Illnesses of mother 0.0 0.0 0.1 0.1 0.2 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 8.7 -3.0 -0.3 0.3
Pulse wave Arterial Stiffness index 0.9 1.0 1.2 1.1 1.1 0.9
Impedance of arm (left) 0.0 0.1 0.2 0.1 -0.2 -0.4
Arm fat mass (right) 0.1 0.3 0.4 -0.5 -0.6 -0.4
Trunk predicted mass 0.4 2.2 3.8 -0.9 1.9 -1.4
Standing height 0.4 4.4 6.6 -1.0 2.6 -2.4
Length of working week for main job 0.3 0.3 0.8 -0.9 0.2 0.2
Exposure to tobacco smoke at home 0.3 0.4 0.6 0.7 0.1 0.8
Breastfed as a baby 2.8 3.5 5.6 -2.0 1.0 -2.4
Tense / ‘highly strung’ 4.3 7.1 18.9 -0.7 -4.3 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.6 -0.5 0.3
Hair/balding pattern: Pattern 4 0.6 1.4 2.5 -1.6 -0.8 -1.1
Birth weight of first child 1.4 2.5 5.5 0.1 2.3 -1.4
Peak expiratory flow (PEF) 0.6 1.5 4.4 -2.1 -0.3 0.2
Pulse wave reflection index 1.7 2.2 3.4 1.9 1.6 0.8
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.2 -0.8 -1.5 0.2
Loud music exposure frequency 0.2 0.2 0.5 0.3 -0.7 -0.2
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 3.8 -0.3 2.0 -1.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.3 1.1 -0.8 -0.0
Blood clot in the leg (DVT) 1.4 1.8 3.1 -0.4 -1.8 1.4
Medication: Paracetamol 0.2 0.3 0.6 -0.0 -0.8 0.4
Headache pain in last month 1.1 1.9 2.7 -1.4 -1.7 1.1
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 5.0 0.8 2.2 -1.1
Glaucoma (self-reported) 0.4 0.5 1.5 -0.3 -1.2 0.1
Gout (self-reported) 0.7 1.0 1.4 1.1 0.7 -1.2
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.2 -0.0 -0.4 0.1
Medication: Amlodipine 0.2 0.3 0.9 -0.1 0.1 -1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 0.9 0.7 0.2
Birth weight 2.9 6.4 9.4 -3.1 1.1 -2.9
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.7 1.6 -0.7 0.5
High blood pressure (siblings) 0.0 0.1 0.1 -0.3 -0.2 0.1
Forced vital capacity (FVC), Best measure 0.5 1.9 5.2 -2.3 0.7 -0.4
Body fat percentage 0.2 1.0 2.6 -0.6 -1.6 0.1
Leg fat percentage (right) 0.3 1.0 2.5 -0.6 -1.6 0.3
Arm fat-free mass (right) 0.2 0.9 1.5 -1.2 0.9 -0.6
Exposure to tobacco smoke outside home 2.3 3.1 8.0 0.7 -0.8 2.8
Comparative body size at age 10 0.1 0.3 0.5 -0.7 -0.7 0.0
Number of full brothers 1.7 2.1 4.7 -0.0 1.3 -2.2
Worry too long after embarrassment 1.2 1.9 3.6 -1.2 -1.9 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.5 0.4 -0.7 0.3
Wheeze or whistling in the chest in last year 1.0 1.9 4.5 -0.1 -2.1 1.0
Number of children fathered 0.2 0.2 0.3 -0.1 0.5 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.8 -0.9 -0.3 -0.3
Age at first live birth 0.3 0.4 1.1 -0.1 0.4 1.1
Pulse wave peak to peak time 0.7 0.9 0.9 -0.9 -1.0 -0.9
Health satisfaction 0.7 0.9 1.8 -0.8 -1.3 0.6
Shortness of breath walking on level ground 0.9 1.0 2.1 1.5 -0.7 -0.7
Qualifications: College or University degree 0.7 2.2 6.2 0.5 2.5 -0.5
Eye problems/disorders: None of the above 4.5 5.2 10.9 1.0 1.9 -3.3
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.3 1.1 -0.9 0.9
Emphysema/chronic bronchitis 1.0 1.1 1.9 -0.3 -1.2 1.4
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 -1.3 -0.1 -0.3
Neck or shoulder pain in last month 0.1 0.1 0.3 0.2 0.6 -0.1
Medication: Blood pressure 0.1 0.3 0.4 -0.3 -0.7 -0.5
Angina (self-reported) 0.7 0.9 2.1 0.8 0.2 1.4
Migraine (self-reported) 0.4 0.5 1.2 0.6 -1.1 -0.2
Medication: Ibuprofen 3.0 3.6 7.0 2.6 1.8 -0.8
Medication: Allopurinol 1.1 1.4 2.7 0.3 1.2 -1.7
Medication: Omeprazole 0.1 0.1 0.2 0.1 -0.4 -0.4
Medication: Seretide 50 evohaler 0.6 0.6 1.0 1.0 -0.0 0.9
Mean time to correctly identify matches 1.0 1.8 2.9 1.1 1.7 -1.2
Heart disease (mother) 0.2 0.3 0.5 0.7 0.3 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.9 -1.4 -1.4 -0.3
Whole body fat mass 0.1 0.5 0.7 -0.7 -0.9 -0.5
Leg fat mass (right) 0.2 0.6 1.4 -0.6 -1.2 -0.0
Arm predicted mass (right) 0.2 1.0 1.4 -1.2 0.9 -0.8
Pulse rate, automated reading 0.5 1.6 2.9 -1.7 -0.4 -1.3
Alcohol intake frequency. 0.3 0.7 1.0 1.0 0.1 1.0
Comparative height size at age 10 0.5 2.6 4.1 0.6 1.8 -2.0
Number of full sisters 0.1 0.1 0.2 0.5 0.3 0.2
Suffer from ‘nerves’ 1.4 2.2 5.2 0.8 -2.3 0.9
Overall health rating 1.5 3.2 7.3 -1.5 -2.7 -0.1
Chest pain or discomfort 8.1 11.7 21.9 -2.6 -4.7 2.5
Had major operations 0.6 0.7 1.5 -0.8 -1.2 -0.1
Age at last live birth 0.1 0.1 0.3 0.0 0.3 0.6
Family relationship satisfaction 0.6 0.8 1.0 -1.0 -0.8 0.9
Leg pain on walking 0.4 0.5 0.9 1.0 -0.8 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 4.8 2.2 1.2 0.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.2 -0.1 0.6
Illness, injury, bereavement, stress in last 2 years 2.7 3.4 6.6 -1.0 1.6 -2.6
Medication: Aspirin 0.8 1.1 1.6 -0.8 -1.3 1.0
Supplements: Vitamin C 0.0 0.1 0.1 -0.3 0.1 -0.2
Knee pain experienced in last month 0.1 0.1 0.2 -0.2 -0.4 -0.2
Hypertension (Self-reported) 0.6 1.8 3.8 0.8 -2.0 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.0 -0.4 0.3 -1.0
Illnesses of father: Heart disease 0.8 1.1 1.8 0.6 1.3 -1.1
Illnesses of siblings: Diabetes 1.3 1.6 4.8 -0.3 -0.2 2.2
Smoking status: Previous 0.2 0.3 0.8 -0.9 -0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.0 -0.2 1.0 -0.1
Whole body fat-free mass 0.3 1.7 2.5 -0.9 1.6 -1.4
Leg fat-free mass (right) 0.2 1.1 1.8 -0.2 1.2 -1.3
Arm fat percentage (left) 0.1 0.5 1.4 -0.3 -1.2 0.0
Average weekly red wine intake 0.1 0.2 0.5 -0.1 0.7 -0.1
Handedness (chirality/laterality): Left-handed 1.5 1.8 2.6 -1.3 -1.6 -1.0
Mood swings 3.6 6.6 15.5 -1.8 -3.9 1.0
Loneliness, isolation 1.9 2.6 5.4 -0.2 -2.3 1.6
Long-standing illness, disability or infirmity 0.1 0.2 0.5 -0.4 -0.1 -0.7
Ever had bowel cancer screening 0.5 0.6 1.2 -1.1 0.0 -0.7
Diabetes diagnosed by doctor 1.8 3.0 5.3 0.4 -1.8 2.3
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.0 -0.1 0.5
Friendships satisfaction 1.7 2.2 3.7 -1.5 -1.9 0.7
Qualifications: nursing, teaching 0.5 0.8 1.1 -0.9 1.0 -0.7
Commuting to job workplace: Walk 0.3 0.3 0.7 -0.1 -0.8 0.4
Eye problems/disorders: Cataract 1.8 2.0 3.7 -1.4 -0.8 1.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.4 0.7 0.1 0.5
Medication for cholesterol 0.6 0.9 2.3 -0.2 1.5 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.5 -0.1 -0.7 -0.0
Back pain experienced in last month 2.3 3.4 4.8 -2.2 -2.2 0.8
Mineral and other dietary supplements 0.6 0.8 1.4 1.2 -0.7 0.8
Breast cancer (self-reported) 1.0 1.2 3.4 -0.4 -1.8 0.3
Asthma (self-reported) 0.3 0.6 0.8 -0.9 -0.8 -0.5
Osteoporosis (self-reported) 1.6 2.0 4.3 -0.6 -2.1 1.2
Osteoarthritis (self-reported) 0.1 0.2 0.4 -0.6 -0.3 -0.3
Medication: Aspirin 0.6 0.8 1.2 -0.9 -1.1 0.6
Medication: Gliclazide 0.4 0.4 0.7 -0.2 -0.8 0.8
Illnesses of father: None of the above (group 1) 2.5 3.1 5.0 -0.5 2.0 -2.2
Smoking status: Current 0.7 1.1 2.9 1.7 0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.8 -1.3 -0.1 -0.1
Whole body water mass 0.3 1.6 2.4 -0.8 1.6 -1.2
Leg predicted mass (right) 0.2 1.0 1.6 -0.2 1.1 -1.2
Arm fat mass (left) 0.0 0.2 0.2 -0.4 -0.4 -0.4
Number of self-reported non-cancer illnesses 2.2 3.8 7.9 -1.2 -2.8 1.5
Average weekly champagne plus white wine intake 0.4 0.5 1.4 -1.2 -0.3 0.1
Miserableness 1.7 3.0 6.1 -1.4 -2.5 1.0
Guilty feelings 5.3 8.0 13.4 -2.1 -3.7 2.5
Wears glasses or contact lenses 1.8 2.1 5.6 -0.4 2.4 -0.8
Ever taken oral contraceptive pill 0.7 0.8 1.3 1.2 1.0 -0.3
Hearing aid user 0.3 0.4 1.0 1.0 0.3 -0.0
Mother’s age at death 1.1 1.4 3.9 0.4 2.0 -0.3
Financial situation satisfaction 0.6 0.7 1.2 -1.1 -0.9 -0.3
Tinnitus: Yes, now most or all of the time 2.8 3.2 6.4 -1.5 -2.5 1.0
Commuting to job workplace: Public transport 0.2 0.3 0.7 0.4 0.8 0.1
Eye problems/disorders: Glaucoma 0.5 0.5 1.5 -0.1 -1.2 0.3
Medication: Blood pressure 0.4 0.8 2.0 0.5 -1.4 -0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.4 -0.1 -1.1 1.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.4 -1.2 0.2 -0.3
High cholesterol (Self-reported) 0.5 0.9 1.6 -0.3 -1.3 1.0
Medication: Bendroflumethiazide 1.4 2.2 4.3 -1.2 -2.1 0.8
Medication: Paracetamol 0.1 0.2 0.6 -0.3 0.1 -0.7
Medication: Lisinopril 2.3 3.0 4.4 -2.1 -1.8 1.1
Medication: Atorvastatin 0.9 1.2 2.1 -0.0 -1.5 1.2
Illnesses of father: High blood pressure 1.2 1.4 2.1 -1.2 -1.5 0.8
Alcohol drinker status: Never 0.9 1.0 2.3 1.5 -0.2 0.9
Ever smoked 0.7 1.3 2.6 0.1 1.6 -1.2
Basal metabolic rate 0.2 1.3 1.7 -0.8 1.3 -1.3
Leg fat percentage (left) 0.3 1.2 3.5 -0.4 -1.9 0.3
Arm fat-free mass (left) 0.2 1.0 1.2 -1.1 1.0 -0.9
Number of operations (self-reported) 1.7 2.5 4.2 -2.1 -1.0 -1.5
Average weekly beer plus cider intake 0.3 0.4 0.9 -0.3 -0.6 0.9
Irritability 3.7 6.3 11.6 -2.5 -3.4 0.9
Risk taking 0.1 0.2 0.2 -0.5 0.1 -0.5
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.8 0.9 0.0 1.3
Fractured/broken bones in last 5 years 0.5 0.6 0.8 0.9 0.5 -0.9
Age started oral contraceptive pill 0.5 0.7 1.8 1.4 0.2 0.2
Diastolic blood pressure, automated reading 0.1 0.3 0.4 0.7 0.4 -0.5
Ever depressed for a whole week 0.1 0.1 0.2 -0.4 -0.2 0.0
Unable to work because of sickness or disability 0.5 0.7 2.0 0.2 -0.3 -1.4
Commuting to job workplace: Cycle 0.3 0.3 0.5 0.5 -0.7 0.5
Myopia 0.2 0.3 0.7 0.4 0.1 -0.8
Vascular/heart problems diagnosed by doctor 0.9 2.4 4.0 -1.2 2.0 -1.4
Cholesterol lowering medication 0.4 0.6 0.8 0.8 -0.9 0.5
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.2 -0.3 -0.5
Pain experienced in last month 1.1 1.9 2.7 1.4 1.6 -0.9
Supplements: Calcium 0.1 0.1 0.3 -0.3 0.5 0.3
Basal cell carcinoma (self-reported) 0.4 0.5 0.8 -0.5 0.7 -0.9
Heart attack/myocardial infarction (self-reported) 0.9 1.1 2.8 0.4 0.6 -1.7
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 2.9 -0.5 -1.7 1.5
Heart disease (siblings) 0.1 0.1 0.2 -0.2 -0.4 -0.4
Alcohol drinker status: Previous 0.6 0.7 1.4 0.4 1.2 -0.8
Pack years of smoking 0.9 1.3 2.5 1.6 0.1 -1.2
Impedance of whole body 0.1 0.7 1.5 -0.7 -1.2 0.2
Leg fat mass (left) 0.2 0.7 1.7 -0.5 -1.3 0.2
Arm predicted mass (left) 0.2 1.0 1.5 -1.2 0.9 -0.8