Hub : Genes

ADCK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.08 0.026 6.0e-05 0.043 0.037 0.027 0.038 0.027 5.5e-06 2.4e-05 2.7e-04 1.7e-05 2.6e-04
2 GTEx Adipose Visceral Omentum 0.11 0.051 5.2e-03 -0.002 NA 0.025 NA 0.014 4.5e-01 NA 1.7e-02 NA 6.1e-02
3 GTEx Esophagus Gastroesophageal Junction 0.23 0.076 2.7e-04 0.115 NA 0.082 NA 0.091 6.1e-05 NA 6.5e-04 NA 3.6e-04
4 GTEx Esophagus Muscularis 0.07 0.031 9.2e-03 0.024 NA 0.006 NA 0.015 1.3e-02 NA 1.2e-01 NA 4.1e-02
5 GTEx Whole Blood 0.14 0.034 3.5e-10 0.166 NA 0.153 NA 0.167 3.9e-15 NA 5.7e-14 NA 3.4e-15
6 NTR Blood 0.06 0.016 5.6e-17 0.085 0.040 0.076 0.006 0.001 5.0e-26 7.0e-13 2.5e-23 3.9e-03 9.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Alzheimer’s Disease (in mother) 2.1 2.5 4.2 -1.8 -1.3 -1.2 -0.8 2.0 1.9
Alzheimer’s Disease (in father) 0.8 0.9 1.8 -0.2 0.6 0.1 1.1 -1.4 -1.4
Alzheimer’s Disease (including proxy) 0.5 0.8 1.8 -1.3 -0.3 -0.9 0.8 0.8 0.7
Crohns Disease (2017) 0.5 1.1 2.7 1.0 -1.6 0.5 1.5 -0.6 -0.3
Irritable Bowel Disease (IBD) 1.7 4.1 9.9 0.6 -0.9 3.2 3.1 -1.4 -1.3
Ulcerative Colitis (UC) 2.5 4.8 15.7 -0.3 -0.9 4.0 3.2 -0.9 -0.9
Major Depression (MDD) 1.1 1.4 3.8 0.2 -0.4 -2.0 -1.5 0.8 1.2
Reaction Time 1.0 1.9 6.8 2.6 1.4 -1.2 -1.1 -0.1 -0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.8 3.9 -0.1 -0.4 2.0 -0.8 0.2 0.2
Breast Cancer 0.5 1.3 3.4 1.4 -0.5 -1.9 -0.9 0.8 0.8
Ovarian Cancer 0.4 0.5 0.8 -0.5 0.9 -0.5 -0.8 0.7 0.7
Prostate Cancer 2.3 3.3 5.7 -1.2 -2.4 -2.1 -0.9 2.0 1.9
Age at First Birth 0.7 1.1 3.3 -0.6 -1.8 -0.9 -0.7 0.8 0.9
Bipolar Disorder 0.5 0.5 2.4 0.1 1.6 -0.6 -0.4 0.1 0.1
Body Mass Index (BMI) (2010) 0.1 0.1 0.5 0.2 -0.1 -0.7 -0.0 0.1 0.1
Coronary Artery Disease (CAD) 0.3 0.3 1.1 -0.2 0.6 1.1 0.5 -0.1 -0.3
Crohns Disease (2012) 0.3 0.5 1.5 -0.8 1.2 -0.5 -0.8 0.4 0.0
Mean Putamen Volume 0.5 0.6 2.2 -0.3 -0.4 1.5 1.0 0.1 -0.2
Fasting Glucose 1.2 1.5 3.2 1.5 1.8 -0.2 -0.2 -1.4 -1.0
HbA1C 1.4 1.5 4.9 1.8 2.2 0.0 -1.1 -0.1 0.1
HDL Cholesterol 0.5 0.9 3.0 -0.3 0.7 1.7 1.2 -0.0 -0.0
LDL Cholesterol 0.8 1.2 3.3 -1.1 -1.3 0.9 1.8 -0.6 -0.3
Lupus 0.7 1.0 3.9 0.2 2.0 1.2 0.8 0.3 0.2
Neuroticism 3.4 5.0 10.1 -1.2 -1.7 -3.2 -2.3 2.1 2.5
Primary Biliary Cirrhosis 1.1 1.5 2.4 -0.7 0.2 -1.5 -1.5 1.5 1.5
Rheumatoid Arthritis 0.8 1.0 2.2 1.5 1.4 0.8 0.5 -0.8 -0.7
Schizophrenia 1.2 2.6 4.8 -1.1 -0.1 -2.2 -1.5 1.9 2.0
Triglycerides 1.1 1.7 3.2 -0.5 -1.8 -1.7 -0.8 1.2 1.4
Type 2 Diabetes (T2D) 1.1 1.3 3.0 0.0 -0.5 0.7 1.4 -1.7 -1.3
Ulcerative Colitis 1.7 2.4 9.1 0.7 1.3 -3.0 -1.6 0.5 0.6
Blood Eosinophil Count 0.3 2.5 12.5 -0.0 0.9 -3.5 -1.2 -0.2 0.1
Blood Platelet Count 0.1 0.9 1.6 -0.8 0.9 0.7 -1.3 1.3 0.6
Blood Red Count 0.7 7.0 11.7 -3.1 -1.7 -2.7 0.8 3.4 3.2
Blood White Count 4.3 31.8 69.2 3.8 5.3 2.0 3.7 -7.9 -8.3
Heel T-Score 3.2 25.6 53.1 -3.0 -1.2 -7.3 -5.0 5.7 5.6
BMI 0.3 1.7 5.7 -0.0 0.9 2.4 0.8 -1.3 -1.1
Height 0.8 16.6 39.1 -3.0 -5.9 -2.8 -6.2 1.8 2.4
Waist Hip Ratio (WHR) 3.0 13.7 17.3 -3.6 -3.9 -3.0 -3.4 4.1 4.2
Systolic Blood Pressure 1.0 5.0 12.9 2.1 0.8 -2.4 -3.6 2.1 1.5
Smoking Status 0.5 1.2 4.6 -0.9 1.0 2.1 -0.1 -0.5 -0.6
Allergy or Eczema 1.5 4.0 7.1 -0.5 -1.1 -2.4 -1.6 2.6 2.7
Cardiovascular Disease 1.1 3.5 8.6 0.0 -0.7 -1.3 -2.9 2.3 2.2
Hypothyroidism (self reported) 0.5 1.2 4.6 -2.1 0.3 -1.4 -0.5 0.4 0.5
Respiratory disease 0.9 2.0 4.5 -0.0 0.2 -1.4 -1.2 1.9 2.1
Type 2 Diabetes (T2D) 0.3 0.5 1.4 -1.2 -0.1 0.0 -0.8 0.6 0.7
Lung FEV1/FVC ratio 1.1 5.4 21.3 -0.5 -2.0 4.6 1.8 -1.3 -1.3
Lung FVC 0.4 1.9 3.6 0.3 1.6 1.7 1.9 -1.0 -1.3
Neuroticism 5.3 13.1 27.4 -0.8 -1.8 -5.2 -4.2 3.8 3.9
Chronotype (morning person) 0.4 1.0 5.2 0.1 0.5 2.3 0.8 -0.1 -0.1
Hair Pigment 0.4 13.5 31.5 -2.7 0.0 5.6 4.8 -3.2 -3.0
Tanning 0.2 3.0 8.0 -1.1 -2.2 -1.8 2.8 0.6 0.6
Hand grip strength (left) 3.6 9.7 19.1 -0.4 -0.8 -4.4 -3.5 3.5 3.7
Number of treatments/medications taken 1.9 3.5 6.4 1.1 1.2 1.6 2.1 -2.5 -2.2
Average weekly spirits intake 0.1 0.2 0.4 -0.5 0.3 -0.7 -0.3 0.3 0.3
Sensitivity / hurt feelings 0.4 0.6 1.0 -0.9 -1.0 0.8 0.9 -0.5 -0.6
Frequency of depressed mood in last 2 weeks 2.7 3.8 6.1 1.4 1.2 2.0 1.9 -2.4 -2.5
Hearing difficulty/problems: Yes 1.2 1.8 4.0 0.4 1.0 1.7 0.2 -1.7 -2.0
Relative age of first facial hair 0.9 2.0 4.9 0.1 -0.5 -2.0 -2.2 1.2 1.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 3.1 1.8 1.1 0.3 0.1 -0.3 -0.4
Ever used hormone-replacement therapy (HRT) 1.3 1.7 4.1 1.0 0.8 0.3 0.5 -2.0 -2.0
Ever had hysterectomy (womb removed) 1.5 1.7 5.0 1.6 -1.4 -2.2 -0.8 0.3 0.2
Systolic blood pressure, automated reading 0.3 0.8 1.8 -1.3 -0.4 1.3 1.0 -0.2 0.2
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.1 0.8 -0.2 -1.8 -1.1 1.7 1.5
Angina 2.3 2.9 4.9 1.9 1.3 0.2 1.7 -2.1 -2.2
Medication for hormone replacement therapy 0.2 0.2 0.9 -0.1 0.1 1.0 -0.0 -0.3 -0.3
Vitamin and mineral supplements 0.3 0.4 1.7 -0.3 -0.3 0.4 1.3 -0.4 -0.2
Supplements: Zinc 0.6 0.7 2.0 0.4 0.5 1.4 1.1 -0.4 -0.5
Medication: Co-codamol 0.7 0.8 3.2 1.8 1.1 -0.1 0.6 -0.4 -0.5
Medication: Metformin 0.7 0.9 3.9 2.0 0.5 -0.8 0.2 -0.4 -0.7
Diabetes (father) 0.7 0.9 1.7 0.5 -0.5 -1.2 -0.4 1.3 1.1
Diabetes (mother) 1.2 1.5 5.0 1.5 2.2 0.0 -1.2 -0.7 -0.4
Severe depression (siblings) 1.2 1.3 3.4 -0.5 0.1 1.2 1.9 -1.1 -1.2
Pack years adult smoking proportion 0.2 0.4 1.3 0.3 -0.4 0.5 -1.1 0.5 0.5
Impedance of leg (right) 4.1 20.0 29.8 1.3 3.5 5.0 5.5 -4.9 -5.2
Leg fat-free mass (left) 1.1 5.7 13.3 1.2 -0.3 -3.6 -1.2 3.0 3.0
Trunk fat percentage 0.4 1.6 4.1 2.0 1.4 -0.7 0.6 -0.9 -1.4
Hand grip strength (right) 1.9 5.3 14.0 -0.3 -0.3 -3.7 -2.5 2.4 2.4
Townsend deprivation index at recruitment 0.1 0.1 0.3 -0.4 0.3 0.0 0.5 -0.1 -0.2
Current tobacco smoking 1.4 2.3 3.9 -0.4 -1.0 -2.0 -1.6 1.8 1.8
Average weekly fortified wine intake 1.1 1.3 2.8 -1.0 -0.7 -0.9 -0.7 1.7 1.6
Maternal smoking around birth 2.2 3.2 11.8 0.5 -0.2 -3.4 -2.0 1.2 1.3
Fed-up feelings 1.6 2.9 4.5 0.5 1.5 1.8 2.1 -1.8 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.8 1.3 -0.0 0.7 0.4 -0.9 -0.6
Relative age voice broke 0.3 0.4 0.8 0.9 0.7 -0.4 -0.8 0.4 0.5
Taking other prescription medications 2.0 3.1 4.5 2.1 1.3 1.4 1.5 -2.1 -1.9
Age when periods started (menarche) 0.2 0.5 0.7 0.8 0.8 -0.3 -0.4 -0.8 -0.8
Bilateral oophorectomy (both ovaries removed) 1.2 1.3 2.4 1.4 0.3 -1.2 0.0 -1.4 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 4.9 11.1 24.1 2.5 1.8 4.9 3.8 -2.9 -3.2
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 1.2 -0.7 -0.5 -0.6 0.6 0.5
Qualifications: CSEs or equivalent 0.3 0.4 1.1 0.4 0.4 -0.2 1.0 -0.6 -0.8
Serious illness, injury or assault to yourself 0.6 0.8 1.6 1.0 1.3 -0.3 0.5 -0.8 -1.1
High blood pressure 0.3 0.7 1.7 -0.6 0.8 -0.4 1.3 -0.9 -0.9
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.3 0.4 0.7 1.5 0.6 -1.3 -1.4
Multivitamins +/- minerals 0.8 1.0 3.1 0.4 0.0 -1.2 -1.7 1.0 0.8
Stomach or abdominal pain in last month 0.3 0.4 1.1 0.6 0.4 0.5 1.0 -0.4 -0.5
Supplements: Glucosamine 0.9 1.1 2.6 -0.3 -0.2 -1.1 -0.8 1.5 1.6
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 4.0 2.0 1.7 -0.8 -0.4 -0.8 -0.7
Medication: Atenolol 0.3 0.3 1.1 -0.6 1.1 -0.1 0.8 -0.0 0.1
Medication: Levothyroxine sodium 2.0 3.3 7.0 1.4 -0.9 2.6 1.9 -1.8 -1.9
Sitting height 0.4 3.2 11.2 2.4 1.0 1.1 3.3 0.0 0.4
Chronic bronchitis/emphysema (father) 0.2 0.2 0.8 0.1 -0.9 -0.1 -0.5 -0.4 -0.4
High blood pressure (mother) 1.0 1.4 3.1 -1.8 -0.4 -1.1 -0.2 1.4 1.4
Body mass index (BMI) 0.9 4.0 11.2 0.9 -0.6 -3.3 -2.2 1.9 1.7
Impedance of leg (left) 4.1 20.4 29.2 1.3 3.2 5.3 5.4 -5.0 -5.3
Leg predicted mass (left) 1.0 5.6 12.9 1.2 -0.3 -3.6 -1.1 3.0 3.0
Trunk fat mass 0.3 1.5 4.7 2.2 1.3 -1.5 0.4 0.0 -0.4
Waist circumference 0.4 1.5 4.6 2.1 1.4 -1.5 0.1 0.5 0.3
Number of incorrect matches in round 0.6 1.1 3.1 0.8 -0.2 1.8 1.3 -0.5 -0.8
Past tobacco smoking 0.8 1.5 2.4 -1.4 -0.1 0.7 -1.3 1.5 1.5
Alcohol usually taken with meals 0.4 0.7 1.1 -0.1 0.8 0.9 1.0 -0.8 -0.9
Nervous feelings 4.6 8.7 21.1 0.6 2.6 4.6 2.3 -3.0 -3.1
Frequency of tenseness / restlessness in last 2 weeks 2.8 4.4 7.8 1.6 1.0 2.8 1.8 -2.5 -2.4
Hearing difficulty/problems with background noise 1.0 1.6 4.6 -0.1 0.2 2.1 1.6 -1.1 -1.1
Hair/balding pattern: Pattern 2 0.9 1.2 2.4 0.6 1.3 0.8 0.8 -1.2 -1.5
Had menopause 0.6 0.8 1.9 1.3 -0.7 1.4 0.2 -0.4 -0.5
Had other major operations 1.1 1.3 2.9 1.7 1.6 -1.5 -0.4 -0.2 -0.0
Forced vital capacity (FVC) 0.1 0.5 1.0 0.9 1.0 -0.0 0.7 -0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 5.0 11.6 22.0 3.0 2.1 4.7 3.5 -3.3 -3.3
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 4.4 0.4 0.5 0.9 2.1 -0.9 -1.1
Qualifications: None of the above 1.1 2.4 4.0 2.0 -0.3 1.7 1.2 -1.9 -1.7
Financial difficulties in last 2 years 0.2 0.3 0.8 0.1 0.9 0.3 -0.0 -0.7 -0.8
Mouth/teeth dental problems 0.2 0.3 0.8 -0.9 0.1 -0.0 -0.3 0.3 0.7
Heart attack 1.7 2.2 3.1 1.7 1.1 -0.7 1.8 -1.6 -1.7
Allergy 0.3 0.8 1.5 -0.9 0.4 -0.9 -0.2 1.1 1.2
Pain all over the body in last month 0.5 0.5 1.4 0.2 -0.1 -1.0 -0.6 0.6 1.2
Diabetes (self-reported) 0.6 1.0 4.9 2.2 0.3 -0.9 -0.1 0.0 -0.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.5 0.2 1.1 0.4 -0.8 -1.2 -1.0
Medication: Ramipril 2.0 2.5 4.5 -0.2 1.2 1.0 1.9 -2.1 -2.1
Medication: Simvastatin 0.4 0.5 2.3 1.5 0.6 -0.6 0.2 -0.2 -0.2
Fluid intelligence score 0.2 0.5 2.2 0.4 0.4 -1.5 -0.3 -0.2 -0.2
Illnesses of siblings 0.2 0.2 0.5 0.2 0.7 0.7 0.4 0.4 0.4
Neuroticism score 5.9 12.6 24.3 0.8 1.8 4.9 4.1 -3.9 -4.0
Weight 0.4 2.3 5.4 2.0 1.2 -2.3 0.2 1.2 1.0
Impedance of arm (right) 3.4 16.0 25.3 0.7 3.4 4.7 3.8 -4.8 -5.0
Arm fat percentage (right) 0.3 1.3 3.6 1.9 1.0 -1.4 -0.7 -0.4 -0.7
Trunk fat-free mass 0.9 5.1 11.5 1.0 0.3 -2.8 -0.5 3.2 3.4
Hip circumference 0.8 3.5 9.0 1.3 0.3 -3.0 -0.7 2.3 2.1
Time employed in main current job 1.0 1.2 2.1 -1.4 -1.2 -1.0 -1.5 0.5 0.7
Alcohol intake versus 10 years previously 1.1 1.6 5.8 0.0 0.4 2.4 1.5 -0.8 -0.8
Father’s age at death 1.0 1.3 3.4 0.2 0.3 -0.8 -1.9 1.3 1.4
Worrier / anxious feelings 3.8 7.2 17.5 0.5 0.9 4.2 3.3 -2.7 -2.5
Frequency of tiredness / lethargy in last 2 weeks 3.2 5.3 7.1 2.0 2.3 2.3 1.9 -2.5 -2.7
Falls in the last year 0.4 0.6 1.7 1.1 -1.3 -0.7 -0.3 0.1 0.0
Hair/balding pattern: Pattern 3 1.3 2.0 4.4 -1.6 -2.1 0.1 -0.7 1.4 1.6
Number of live births 0.9 1.3 3.6 1.4 0.7 -1.9 -1.1 0.5 0.4
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.7 1.0 1.6 -1.5 -0.0 -0.3 -0.0
Pulse rate 0.2 0.4 1.6 1.3 -0.2 -0.0 0.0 -0.5 -0.5
Happiness 1.8 2.2 4.0 0.4 0.8 1.2 2.0 -1.7 -1.9
Noisy workplace 1.3 1.6 3.2 -1.4 -1.8 0.1 -0.4 1.5 1.5
Qualifications: A levels/AS levels or equivalent 1.7 3.9 9.7 -3.1 -0.3 -1.1 -1.6 2.3 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.6 0.1 0.7 -0.8 -0.7 0.1 -0.1
Mouth/teeth dental problems: Dentures 4.7 7.9 21.4 0.9 -1.4 -4.6 -3.6 2.3 2.2
Asthma 1.8 3.6 6.2 0.9 -0.3 2.1 2.5 -2.2 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.3 -0.9 -1.1 -1.0 -0.3 0.1 0.0
Medication: Cholesterol lowering 1.1 1.8 3.8 1.2 1.2 0.8 2.0 -1.2 -1.3
Depression (self-reported) 0.9 1.0 1.9 -0.9 0.7 1.4 1.3 -0.9 -0.8
Medication: Lansoprazole 0.2 0.2 0.4 -0.7 0.0 -0.6 0.3 0.3 0.3
Prospective memory result 0.9 1.1 2.5 -1.6 0.0 -0.5 -0.0 1.5 1.2
Lung cancer (father) 1.5 1.7 5.4 -0.2 -0.3 -2.3 -1.8 0.9 0.7
Illnesses of mother 0.1 0.1 0.4 -0.6 -0.0 0.2 0.1 0.5 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 4.3 0.5 2.1 -0.3 0.3 -0.5 -0.4
Pulse wave Arterial Stiffness index 0.5 0.6 1.4 1.2 -0.0 -0.5 1.0 -0.8 -0.6
Impedance of arm (left) 2.4 11.1 19.9 0.5 2.4 3.7 3.1 -4.2 -4.5
Arm fat mass (right) 0.5 2.0 6.0 1.8 0.7 -2.4 -1.0 1.0 0.7
Trunk predicted mass 0.9 5.2 11.4 0.9 0.2 -2.8 -0.5 3.2 3.4
Standing height 0.8 8.1 21.5 2.6 3.9 1.7 4.6 -1.1 -1.2
Length of working week for main job 0.7 0.8 1.2 -0.6 -1.1 -0.8 1.1 0.8 0.8
Exposure to tobacco smoke at home 0.9 1.0 2.2 1.5 0.3 1.0 0.6 -1.1 -0.9
Breastfed as a baby 1.2 1.5 4.1 -2.0 -0.5 1.4 -0.5 1.2 1.0
Tense / ‘highly strung’ 4.7 7.9 16.4 1.4 1.1 4.0 3.3 -2.9 -2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 5.6 8.7 14.4 1.2 1.8 3.8 2.7 -3.5 -3.6
Hair/balding pattern: Pattern 4 0.1 0.3 1.0 0.7 0.1 -1.0 -0.1 0.3 0.6
Birth weight of first child 1.4 2.6 5.8 0.4 -0.8 -2.4 -2.4 1.1 1.4
Peak expiratory flow (PEF) 1.0 2.3 7.3 1.4 1.8 -2.7 -0.9 -0.4 -0.2
Pulse wave reflection index 0.6 0.7 2.0 1.4 -0.1 -1.4 -0.1 -0.3 -0.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.0 -0.1 -0.4 0.8 1.4 -0.4 -0.5
Loud music exposure frequency 0.2 0.2 0.7 0.8 0.4 -0.4 0.6 -0.0 -0.2
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 4.6 -2.1 -0.8 0.2 -0.1 1.4 1.2
Mouth/teeth dental problems: Bleeding gums 5.4 7.0 13.3 1.3 2.0 3.0 1.7 -3.3 -3.6
Blood clot in the leg (DVT) 0.2 0.3 1.3 1.1 -0.4 0.5 -0.1 -0.2 -0.3
Medication: Paracetamol 0.3 0.6 1.3 -0.4 0.3 0.9 0.5 -1.1 -0.9
Headache pain in last month 3.8 6.7 14.7 -0.6 0.1 3.8 3.6 -2.6 -2.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.6 0.2 -0.3 0.2 -1.6 0.7 0.6
Glaucoma (self-reported) 3.5 4.1 7.1 1.8 0.8 1.3 2.7 -2.4 -2.5
Gout (self-reported) 0.1 0.1 0.4 0.3 0.1 0.2 -0.6 0.1 0.1
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 5.2 2.3 -0.3 2.0 0.8 -0.8 -0.9
Medication: Amlodipine 1.1 1.5 4.2 -1.6 -2.0 -0.5 -0.5 0.9 1.0
Medication: Ventolin 100micrograms inhaler 1.3 1.7 2.9 0.9 1.3 1.7 1.0 -1.4 -1.4
Birth weight 1.6 3.5 7.8 0.1 -0.8 -1.6 -1.9 2.6 2.8
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.8 0.7 0.4 -1.3 -0.5 -0.5 -0.4
High blood pressure (siblings) 0.6 0.9 1.9 -0.3 -0.3 0.1 1.3 -1.3 -1.4
Forced vital capacity (FVC), Best measure 0.2 0.8 1.6 0.2 1.3 1.0 1.0 -0.8 -0.5
Body fat percentage 0.4 1.7 4.6 2.1 1.3 -0.9 0.6 -0.9 -1.4
Leg fat percentage (right) 0.5 1.7 5.7 2.4 0.9 -0.9 0.7 -0.9 -1.3
Arm fat-free mass (right) 1.2 6.2 12.1 1.0 -0.7 -3.4 -0.7 3.4 3.5
Exposure to tobacco smoke outside home 2.0 2.7 6.5 -0.9 -2.6 -1.1 -1.2 1.8 1.7
Comparative body size at age 10 0.8 2.4 4.5 -1.9 -2.1 -0.8 0.2 1.7 1.6
Number of full brothers 1.1 1.3 3.6 -0.2 -1.9 -0.8 -1.4 0.8 1.0
Worry too long after embarrassment 3.5 5.9 9.2 0.8 1.9 3.0 2.1 -3.0 -3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.8 8.9 0.7 1.3 3.0 1.7 -2.2 -1.9
Wheeze or whistling in the chest in last year 0.6 1.2 2.2 0.5 0.8 1.0 1.0 -1.4 -1.5
Number of children fathered 0.9 1.0 2.7 1.2 -0.7 -1.0 -1.6 0.4 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 2.1 0.1 1.4 0.4 0.1 -0.2 -0.1
Age at first live birth 1.5 2.8 5.9 -1.3 1.6 1.2 0.6 -2.4 -2.2
Pulse wave peak to peak time 0.4 0.4 0.8 -0.9 0.5 0.7 -0.8 0.6 0.4
Health satisfaction 0.3 0.4 1.0 -0.4 0.4 -0.6 1.0 -0.4 -0.6
Shortness of breath walking on level ground 1.9 2.3 5.9 0.5 0.4 2.4 2.4 -1.0 -0.9
Qualifications: College or University degree 0.2 0.5 1.5 -1.2 0.0 0.5 -0.4 0.7 0.8
Eye problems/disorders: None of the above 3.9 4.6 6.3 -2.1 -1.5 -1.8 -2.4 2.5 2.4
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 0.5 1.0 0.4 0.1 -0.8 -1.1
Emphysema/chronic bronchitis 1.2 1.3 1.9 -1.0 -0.5 -1.3 -1.3 1.4 1.1
Medication for pain relief, constipation, heartburn 0.9 1.5 2.9 -1.2 -0.3 -0.3 -1.6 1.7 1.3
Neck or shoulder pain in last month 1.9 2.7 6.8 2.6 0.7 0.5 1.4 -1.9 -1.8
Medication: Blood pressure 0.5 0.8 2.4 -1.5 -0.7 -0.4 1.4 -0.2 -0.2
Angina (self-reported) 2.3 3.0 5.0 2.1 1.2 0.3 1.5 -2.2 -2.2
Migraine (self-reported) 0.6 0.8 2.1 1.4 -1.3 -0.3 -0.4 -0.7 -0.4
Medication: Ibuprofen 1.1 1.3 4.0 -1.0 -2.0 -1.6 -0.5 0.5 0.4
Medication: Allopurinol 0.1 0.2 0.5 0.7 -0.1 -0.3 -0.6 0.2 0.3
Medication: Omeprazole 1.6 2.0 4.5 1.3 0.7 0.9 2.1 -1.5 -1.4
Medication: Seretide 50 evohaler 2.1 2.5 4.4 1.8 1.4 1.3 2.1 -1.2 -1.4
Mean time to correctly identify matches 1.7 3.4 7.8 -1.9 -1.4 2.8 2.5 -0.6 -0.5
Heart disease (mother) 1.0 1.3 3.1 1.8 1.7 0.1 0.4 -0.9 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.6 -0.4 -0.8 -0.4 -0.6 0.3 0.2
Whole body fat mass 0.4 1.7 4.9 2.2 1.1 -2.0 0.2 0.2 -0.1
Leg fat mass (right) 0.5 1.9 6.1 2.5 1.0 -2.0 0.4 0.3 -0.1
Arm predicted mass (right) 1.2 6.4 13.7 0.6 -0.9 -3.2 -0.7 3.6 3.7
Pulse rate, automated reading 1.4 4.6 16.1 4.0 0.2 -2.5 0.3 -1.5 -1.7
Alcohol intake frequency. 0.9 2.2 4.2 1.0 0.5 1.6 2.1 -1.7 -1.5
Comparative height size at age 10 1.1 6.0 15.9 1.8 2.8 1.8 4.0 -1.6 -1.8
Number of full sisters 0.4 0.4 1.1 0.8 0.2 -0.3 0.4 -1.0 -0.7
Suffer from ‘nerves’ 2.5 4.1 6.6 1.5 2.4 1.9 0.8 -2.4 -2.6
Overall health rating 0.4 0.9 2.4 1.2 -0.1 1.2 1.5 -0.2 -0.3
Chest pain or discomfort 0.2 0.2 1.3 0.0 0.4 1.1 -0.0 -0.2 -0.1
Had major operations 0.2 0.3 0.7 -0.8 -0.3 0.6 0.1 -0.5 -0.3
Age at last live birth 0.2 0.3 0.6 -0.5 0.5 0.4 0.3 -0.8 -0.8
Family relationship satisfaction 0.3 0.4 2.0 0.7 0.2 1.4 -0.2 -0.0 -0.2
Leg pain on walking 2.3 2.9 5.1 -1.4 -1.1 -2.3 -0.8 2.1 2.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.0 -2.0 -1.2 -0.7 -0.8 0.6 0.2
Commuting to job workplace: Car/motor vehicle 3.8 4.3 8.8 0.9 0.4 -3.0 -2.6 2.1 2.3
Illness, injury, bereavement, stress in last 2 years 3.3 4.0 6.6 -2.4 -2.6 -1.2 -0.9 2.1 2.3
Medication: Aspirin 1.8 2.4 5.8 2.4 1.2 0.5 1.0 -1.9 -1.6
Supplements: Vitamin C 0.6 0.7 1.2 -0.2 0.6 1.0 0.7 -1.1 -1.1
Knee pain experienced in last month 0.1 0.1 0.4 0.2 0.4 -0.6 0.2 0.1 -0.0
Hypertension (Self-reported) 0.2 0.5 1.5 -0.6 0.4 -0.6 1.2 -0.7 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 5.6 -0.4 -0.7 2.0 2.4 -1.1 -1.0
Illnesses of father: Heart disease 1.0 1.4 3.0 0.5 -0.1 -0.6 1.7 -1.4 -1.7
Illnesses of siblings: Diabetes 0.2 0.2 0.6 0.4 -0.4 -0.1 -0.0 -0.8 -0.5
Smoking status: Previous 1.0 1.5 2.7 1.2 0.0 -0.0 1.6 -1.5 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.8 6.0 -0.7 0.6 1.9 2.4 0.2 0.1
Whole body fat-free mass 1.0 5.6 11.3 1.1 -0.1 -3.1 -0.8 3.3 3.4
Leg fat-free mass (right) 1.1 5.8 12.5 1.1 -0.5 -3.5 -1.3 3.1 3.1
Arm fat percentage (left) 0.3 1.3 3.8 1.7 0.4 -2.0 -1.0 0.1 -0.2
Average weekly red wine intake 0.3 0.4 1.1 -0.3 0.4 -0.9 -1.1 -0.3 0.0
Handedness (chirality/laterality): Left-handed 1.3 1.6 2.8 0.0 1.6 -0.5 -1.7 1.6 1.3
Mood swings 1.6 2.9 4.2 1.2 0.9 2.0 1.7 -2.0 -2.0
Loneliness, isolation 2.2 3.0 7.2 1.5 2.7 1.4 1.0 -1.6 -1.9
Long-standing illness, disability or infirmity 1.0 1.5 5.0 2.2 1.2 -0.3 0.2 -1.2 -1.0
Ever had bowel cancer screening 0.8 0.9 1.4 -1.2 -1.2 0.9 -0.2 0.9 0.9
Diabetes diagnosed by doctor 0.6 1.0 4.2 2.0 0.2 -1.2 0.1 -0.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.9 0.8 1.0 0.6 1.7 -1.1 -1.5
Friendships satisfaction 0.7 0.9 3.1 -0.1 -0.3 1.7 1.4 -0.4 -0.3
Qualifications: nursing, teaching 0.3 0.4 1.2 -1.1 -0.5 -0.8 -0.6 0.3 0.3
Commuting to job workplace: Walk 0.3 0.3 1.3 -0.4 0.5 1.1 0.2 0.4 0.2
Eye problems/disorders: Cataract 6.3 7.4 10.2 2.7 1.7 2.1 3.0 -3.2 -3.1
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 7.0 -0.7 0.6 1.5 2.7 -0.9 -0.9
Medication for cholesterol 0.3 0.5 1.5 -1.2 -0.6 0.3 0.4 0.8 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.3 -0.4 -0.9 -1.1 -0.1 0.1 0.4
Back pain experienced in last month 0.8 1.2 2.5 1.6 1.6 0.1 0.5 -0.8 -1.1
Mineral and other dietary supplements 0.3 0.5 1.2 0.1 -1.1 -0.4 -1.1 0.3 0.4
Breast cancer (self-reported) 2.5 3.0 3.9 -1.9 -1.9 -1.2 -1.2 1.9 2.0
Asthma (self-reported) 2.0 3.9 5.8 1.0 -0.4 2.3 2.4 -2.3 -2.4
Osteoporosis (self-reported) 0.6 0.8 2.8 0.1 1.7 0.8 1.0 -0.3 -0.3
Osteoarthritis (self-reported) 1.9 2.5 8.1 2.9 1.1 -0.1 0.8 -1.5 -1.6
Medication: Aspirin 1.8 2.4 5.8 2.4 1.0 0.5 1.0 -1.8 -1.6
Medication: Gliclazide 0.7 0.8 2.6 1.3 -0.1 -1.6 -0.4 0.3 0.2
Illnesses of father: None of the above (group 1) 0.2 0.3 0.9 -0.3 0.4 -0.1 -0.2 0.7 0.9
Smoking status: Current 1.4 2.2 4.4 -0.6 -1.2 -2.1 -1.3 1.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.2 -0.9 0.7 -0.1 0.4 1.0 1.1
Whole body water mass 1.0 5.8 11.6 1.0 -0.2 -3.3 -0.8 3.3 3.4
Leg predicted mass (right) 1.1 5.7 12.5 1.1 -0.5 -3.5 -1.3 3.1 3.1
Arm fat mass (left) 0.5 2.3 7.6 1.5 0.4 -2.8 -1.0 1.3 1.0
Number of self-reported non-cancer illnesses 0.7 1.2 2.8 1.1 0.2 1.7 0.8 -1.1 -1.0
Average weekly champagne plus white wine intake 0.2 0.3 0.7 0.5 0.4 0.8 0.6 -0.3 -0.2
Miserableness 1.6 2.9 8.9 -0.4 -0.1 3.0 2.7 -0.5 -0.9
Guilty feelings 2.7 4.1 7.5 -0.0 1.5 2.7 2.3 -2.0 -2.2
Wears glasses or contact lenses 0.1 0.2 0.4 0.3 -0.2 -0.3 0.6 -0.4 -0.5
Ever taken oral contraceptive pill 0.9 1.0 2.3 -1.5 -0.3 -1.0 0.7 -0.9 -0.9
Hearing aid user 1.1 1.2 3.0 0.5 0.5 1.4 0.3 -1.7 -1.4
Mother’s age at death 1.5 1.9 4.1 0.1 0.9 2.0 2.0 -1.0 -1.2
Financial situation satisfaction 0.9 1.1 2.3 0.8 0.8 0.7 0.5 -1.5 -1.5
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.7 -0.2 1.0 1.9 1.8 -0.7 -0.9
Commuting to job workplace: Public transport 2.2 2.6 5.1 0.1 0.3 1.5 2.0 -2.0 -2.3
Eye problems/disorders: Glaucoma 4.8 5.7 8.4 2.8 1.7 1.0 2.6 -2.9 -2.8
Medication: Blood pressure 0.6 1.2 2.3 1.5 0.8 -0.7 0.4 -1.5 -1.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.7 1.3 -0.1 -0.7 -0.6 -0.5 -0.7
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.5 0.8 1.9 0.9 1.6 -1.0 -1.1
High cholesterol (Self-reported) 1.4 2.5 6.7 0.3 1.3 2.6 1.9 -1.3 -1.1
Medication: Bendroflumethiazide 0.5 0.7 1.9 -0.5 0.4 -0.7 0.3 1.2 1.4
Medication: Paracetamol 0.3 0.5 1.3 -0.6 0.5 0.5 -0.2 -1.1 -0.9
Medication: Lisinopril 0.3 0.4 0.9 0.1 0.2 -0.9 -0.6 -0.8 -0.8
Medication: Atorvastatin 2.7 3.3 6.2 1.8 1.0 2.5 2.1 -1.6 -1.6
Illnesses of father: High blood pressure 0.6 0.8 2.2 -1.5 -0.4 -0.7 0.8 0.7 0.6
Alcohol drinker status: Never 0.4 0.5 0.9 1.0 0.6 0.0 0.9 -0.9 -0.6
Ever smoked 0.2 0.4 1.3 1.1 -0.2 -0.5 0.5 -0.6 -0.6
Basal metabolic rate 0.8 4.7 10.1 1.4 0.3 -3.2 -0.6 2.8 2.8
Leg fat percentage (left) 0.4 1.4 5.5 2.3 0.7 -1.1 0.3 -0.6 -1.1
Arm fat-free mass (left) 0.9 4.8 9.1 1.3 0.3 -3.0 -0.4 3.0 3.0
Number of operations (self-reported) 0.3 0.4 1.4 0.5 0.8 -1.2 -0.3 -0.2 0.1
Average weekly beer plus cider intake 1.3 1.9 3.6 -1.9 -1.8 1.3 1.8 0.5 0.0
Irritability 2.9 4.9 10.0 1.1 0.3 3.1 3.2 -2.1 -2.2
Risk taking 0.4 0.6 1.8 1.3 0.9 -0.4 -0.2 -0.7 -0.5
Ever had prostate specific antigen (PSA) test 1.2 1.4 4.6 1.2 2.1 0.6 0.5 -0.8 -1.0
Fractured/broken bones in last 5 years 0.7 0.9 4.5 2.1 0.7 -0.3 0.0 0.6 0.5
Age started oral contraceptive pill 0.6 0.7 2.0 0.9 0.1 -0.2 -1.4 -0.9 -0.8
Diastolic blood pressure, automated reading 1.0 3.1 13.0 -3.6 -1.8 0.9 0.8 0.5 0.9
Ever depressed for a whole week 1.8 2.3 4.4 0.2 0.4 1.4 1.9 -2.1 -1.9
Unable to work because of sickness or disability 4.4 5.7 8.3 2.7 1.9 1.7 2.0 -2.9 -2.9
Commuting to job workplace: Cycle 0.1 0.1 0.6 0.7 0.1 -0.1 0.4 0.1 -0.1
Myopia 0.9 1.3 4.2 -1.0 0.1 2.0 1.2 -0.9 -0.7
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.3 0.3 -1.5 0.4 -1.8 1.6 1.5
Cholesterol lowering medication 0.7 1.0 4.0 2.0 1.3 -0.1 -0.6 -0.3 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.9 1.7 0.5 -0.5 0.8 -0.6 -0.5
Pain experienced in last month 0.5 0.8 3.0 -1.0 -0.7 -0.5 -1.7 0.5 0.3
Supplements: Calcium 0.3 0.3 1.0 -0.2 -1.0 0.5 0.2 0.3 0.5
Basal cell carcinoma (self-reported) 0.3 0.4 1.5 1.2 0.5 0.4 0.2 -0.3 -0.3
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.8 1.6 0.8 -0.5 2.0 -1.3 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 0.9 -0.3 0.8 -0.2 -0.3 -0.3
Heart disease (siblings) 1.7 2.1 7.5 0.9 0.8 -1.7 -2.7 -0.6 -0.4
Alcohol drinker status: Previous 0.4 0.4 1.1 1.1 -0.2 0.8 0.0 -0.7 -0.4
Pack years of smoking 0.5 0.7 2.2 0.1 -0.8 0.4 -1.5 0.8 0.9
Impedance of whole body 3.7 19.0 29.6 0.9 3.2 5.1 4.6 -5.1 -5.4
Leg fat mass (left) 0.5 1.9 5.7 2.4 0.9 -2.1 0.1 0.4 0.1
Arm predicted mass (left) 0.9 4.7 9.3 1.1 0.1 -2.9 -0.5 3.0 3.1