Hub : Genes

AIMP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.1800 0.0620 5.1e-03 0.021 NA 0.024 NA 0.031 2.8e-02 NA 2.1e-02 NA 1.0e-02
2 GTEx Breast Mammary Tissue (Male) 0.0181 0.0747 4.3e-01 -0.012 NA 0.023 NA 0.059 8.2e-01 NA 9.6e-02 NA 1.7e-02
3 GTEx Breast Mammary Tissue (Female) 0.0392 0.0725 3.3e-01 -0.009 NA 0.005 NA -0.008 7.5e-01 NA 2.2e-01 NA 6.4e-01
4 GTEx Lung 0.0731 0.0308 8.0e-03 0.043 NA 0.044 NA 0.046 3.0e-04 NA 2.4e-04 NA 1.8e-04
5 GTEx Testis 0.1590 0.0650 4.0e-03 0.029 NA 0.030 NA 0.035 1.9e-02 NA 1.7e-02 NA 1.1e-02
6 NTR Blood 0.0267 0.0105 4.0e-04 0.007 0.010 0.007 0.010 0.004 1.6e-03 2.9e-04 2.2e-03 2.7e-04 1.6e-02
7 ROSMAP Brain Pre-frontal Cortex 0.0989 0.0290 7.5e-06 0.028 0.056 0.036 0.055 0.034 1.4e-04 9.6e-08 1.7e-05 1.4e-07 2.7e-05
8 YFS Blood 0.1371 0.0223 0.0e+00 0.116 0.160 0.179 0.177 0.180 5.1e-36 7.2e-50 3.6e-56 2.1e-55 1.2e-56
9 TCGA Bladder Urothelial Carcinoma 0.1210 0.0640 7.3e-03 0.045 0.033 0.041 NA 0.037 1.0e-04 8.5e-04 1.9e-04 NA 3.9e-04
10 TCGA Esophageal Carcinoma 0.1300 0.0640 1.7e-03 0.053 0.076 0.020 NA 0.052 8.8e-03 2.0e-03 7.6e-02 NA 9.3e-03
11 TCGA Thyroid Carcinoma 0.1050 0.0530 1.3e-05 0.014 0.031 0.036 NA 0.023 1.6e-02 4.6e-04 1.9e-04 NA 2.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 1.9 3.0 9.4 -2.5 -0.3 0.0 -1.1 -0.8 1.4 -2.6 1.3 -1.7 -1.6 -3.1
Bipolar Disorder or Schizophrenia 1.6 4.0 9.9 -3.1 -1.1 0.0 -2.3 -2.2 2.5 -1.9 0.6 -1.3 -1.2 -3.0
Depressed Affect (Nagel 2018) 0.4 0.8 3.2 -0.1 -0.5 0.0 -0.7 0.3 -0.3 1.4 -1.0 0.7 0.9 1.8
Depression (Nagel 2018) 0.5 0.7 2.3 -0.5 -1.5 0.0 -0.3 0.5 0.6 1.3 0.3 0.5 -0.5 1.5
Intelligence (Savage-Jansen 2018) 0.5 1.4 5.0 1.1 0.4 0.0 2.2 1.4 -0.4 -1.3 0.8 -2.0 0.1 -0.7
Neuroticism (Nagel 2018) 0.3 0.7 3.0 -0.0 -0.4 0.0 -0.4 0.3 -0.4 1.4 -0.8 0.4 1.1 1.7
Schizophrenia (2018) 0.9 1.9 4.6 -2.0 -1.2 0.0 -2.0 -2.1 2.1 -0.4 -0.2 -0.3 -0.3 -1.4
Schizophrenia vs Biploar Disorder 1.5 2.0 4.6 -0.9 -1.9 0.0 -2.1 -2.1 1.2 1.6 -1.1 0.9 0.7 1.5
Worry (Nagel 2018) 0.6 1.3 5.0 0.9 -0.6 0.0 0.9 1.3 0.3 2.2 0.5 0.4 0.1 2.2
Alzheimer’s Disease (in mother) 4.4 5.2 14.1 -2.8 0.4 0.0 -3.8 -3.6 -1.6 -1.5 -3.0 1.1 2.2 -1.3
Alzheimer’s Disease (in father) 0.7 0.8 3.3 1.8 0.8 0.0 1.4 1.0 -0.3 0.2 -0.3 0.5 0.7 0.7
Alzheimer’s Disease (including proxy) 2.4 3.4 8.5 -0.7 1.2 0.0 -2.7 -2.8 -1.3 -0.7 -2.9 1.5 2.7 -0.9
Crohns Disease (2017) 0.2 0.4 1.5 -1.2 -0.5 0.0 -0.6 -0.7 0.6 -0.8 -0.0 0.7 -0.5 -0.4
Irritable Bowel Disease (IBD) 0.4 0.9 2.5 -1.1 -0.8 0.0 -0.2 -0.7 1.6 -1.3 1.0 -0.0 -1.5 -0.3
Ulcerative Colitis (UC) 0.8 1.4 4.2 -1.1 -0.4 0.0 0.1 -0.6 2.0 -1.6 1.6 -0.8 -1.9 -0.5
Major Depression (MDD) 0.5 0.6 2.2 -0.3 -0.5 0.0 -1.0 -0.7 -0.9 -0.4 -1.5 0.7 1.1 0.1
Reaction Time 0.7 1.3 2.6 1.4 1.4 0.0 -0.3 -0.3 -1.0 1.6 -1.2 1.4 1.5 0.8
Verbal and Numeric Reasoning (VNR) 0.4 1.1 3.3 0.3 -0.3 0.0 1.8 0.6 0.8 -1.7 1.2 -1.7 -0.3 -0.1
Breast Cancer 0.9 2.2 7.5 -0.3 -0.6 0.0 1.3 0.7 2.7 -0.6 2.3 -2.3 -1.7 -0.2
Ovarian Cancer 0.7 0.9 3.4 -0.9 1.8 0.0 -0.6 -0.5 1.9 -0.3 0.4 0.9 -0.8 -0.5
Prostate Cancer 0.2 0.3 1.1 -0.0 -0.8 0.0 -0.2 -0.3 0.4 -0.0 0.0 1.0 -0.2 1.0
Age at First Birth 0.3 0.5 2.8 -0.4 0.2 0.0 0.2 0.1 0.4 -0.8 0.4 -0.7 -0.7 -1.7
Bipolar Disorder (2011) 0.8 0.8 6.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.3 -1.0 -2.5
Body Mass Index (BMI) (2010) 0.2 0.3 1.5 -0.8 -0.7 0.0 -1.2 -0.6 -0.3 0.1 -0.5 0.4 0.1 -0.4
Coronary Artery Disease (CAD) 1.2 1.4 6.6 -0.4 -2.6 0.0 -0.1 0.3 0.1 1.5 0.4 1.2 -0.3 2.1
Crohns Disease (2012) 0.2 0.3 1.7 -0.9 -0.2 0.0 -0.3 -0.4 1.3 -0.5 -0.3 0.2 -0.0 -0.1
Mean Putamen Volume 0.9 1.0 3.9 1.0 0.4 0.0 0.1 -0.2 -1.3 -0.9 -1.1 2.0 1.4 0.6
Fasting Glucose 0.5 0.6 3.0 -1.7 -1.0 0.0 -0.2 0.6 0.1 -0.2 0.7 -0.4 -0.6 -1.2
HbA1C 0.9 1.0 2.7 -0.9 -1.2 0.0 -1.2 -0.8 0.0 0.5 -1.2 1.5 0.6 1.7
HDL Cholesterol 0.2 0.3 1.3 0.6 -0.6 0.0 1.1 0.6 0.3 0.3 0.3 -0.1 -0.2 0.8
LDL Cholesterol 0.4 0.7 4.2 0.5 -2.1 0.0 0.4 0.2 0.4 0.4 -0.2 -0.3 0.6 1.3
Lupus 0.2 0.2 0.8 0.6 0.9 0.0 0.5 0.7 -0.2 0.5 0.2 -0.4 0.5 -0.0
Neuroticism (2016) 1.0 1.4 5.3 0.5 -1.0 0.0 -0.5 0.1 0.1 2.1 -1.1 1.4 1.0 2.3
Primary Biliary Cirrhosis 0.3 0.4 2.0 1.3 0.3 0.0 0.7 0.6 -0.2 1.4 0.1 0.3 -0.2 0.2
Rheumatoid Arthritis 0.2 0.3 1.3 -0.6 1.1 0.0 -0.3 -0.2 0.2 -0.1 -0.7 0.6 0.4 -0.1
Schizophrenia (2014) 1.4 3.2 8.0 -2.4 -0.8 0.0 -2.0 -2.2 2.8 -1.0 0.7 -1.3 -1.3 -2.6
Triglycerides 0.5 0.8 3.2 0.7 -0.3 0.0 0.3 0.8 1.2 1.8 0.3 0.8 0.1 1.5
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.8 0.8 -1.7 0.0 -0.4 -0.4 0.1 0.5 0.2 1.1 0.2 0.9
Ulcerative Colitis 1.0 1.4 4.9 -0.8 0.0 0.0 0.1 -0.5 1.9 -2.2 1.5 -0.6 -1.7 -1.0
Blood Eosinophil Count 0.2 1.6 6.7 -0.5 -2.6 0.0 0.9 0.6 0.9 0.4 0.8 -1.7 -1.2 -2.0
Blood Platelet Count 0.2 1.9 6.2 -0.6 0.3 0.0 -1.0 -0.3 -1.4 2.0 -2.5 -0.8 2.5 0.2
Blood Red Count 0.3 3.0 8.1 -0.9 -1.7 0.0 -2.8 -2.6 -1.6 0.3 -1.9 0.7 2.2 1.6
Blood White Count 0.6 4.3 11.2 -0.9 -3.3 0.0 1.4 1.8 1.2 2.6 2.5 -3.3 -2.2 -0.5
Heel T-Score 0.2 1.4 4.8 0.4 0.5 0.0 -1.2 -1.8 -2.2 -1.0 -0.5 0.7 1.0 1.6
BMI 0.4 2.6 9.1 -3.0 -2.0 0.0 -0.6 0.3 0.7 0.0 1.5 -2.2 -2.1 -1.6
Height 0.4 7.0 19.6 -4.3 0.0 0.0 -3.0 -3.1 1.3 -4.2 -0.6 -1.1 -0.6 -4.4
Waist Hip Ratio (WHR) 0.8 3.5 8.5 1.5 0.1 0.0 0.0 0.4 -2.1 2.2 -2.5 2.5 2.4 2.9
Systolic Blood Pressure 0.2 1.0 3.5 -0.1 1.7 0.0 0.9 0.6 0.9 -1.9 1.0 0.1 -1.1 -0.1
Smoking Status 0.4 1.0 4.2 -1.4 -2.0 0.0 -0.5 -0.4 -0.6 -1.9 -0.0 -0.0 -0.3 -0.4
Allergy or Eczema 0.1 0.2 0.6 0.3 0.3 0.0 0.5 0.2 0.5 -0.7 0.3 0.5 -0.6 -0.8
Cardiovascular Disease 0.1 0.4 1.3 0.7 -0.6 0.0 0.8 1.1 -0.7 0.7 0.6 0.8 -0.3 0.4
Hypothyroidism (self reported) 0.3 0.8 2.7 -0.9 0.0 0.0 -1.6 -1.1 -0.4 0.3 -0.9 1.6 0.6 -0.3
Respiratory disease 0.2 0.5 3.1 0.1 0.6 0.0 -0.4 -1.0 0.4 -1.8 -0.5 -0.0 0.3 -0.9
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.5 0.3 -1.1 0.0 0.2 0.4 1.1 1.1 1.2 -1.2 -0.9 -0.1
Lung FEV1/FVC ratio 0.7 3.7 13.0 2.8 -0.1 0.0 2.0 2.2 -1.2 2.9 0.7 0.5 0.4 3.6
Lung FVC 0.9 4.4 25.9 -2.4 -0.5 0.0 -0.1 -0.8 5.1 -1.6 2.4 -0.1 -2.6 -0.6
Neuroticism 0.8 1.9 8.3 0.9 -0.6 0.0 0.4 1.2 -0.4 2.4 -0.9 1.2 1.2 2.9
Chronotype (morning person) 1.4 3.3 9.7 1.5 2.9 0.0 -0.9 -0.6 -2.1 0.8 -2.8 1.2 3.1 0.6
Hair Pigment 0.1 2.6 5.9 -1.6 0.3 0.0 -1.6 -1.8 2.4 -2.4 -0.3 -1.5 -0.8 -2.4
Tanning 0.1 1.5 6.3 2.5 -0.6 0.0 0.9 1.2 -1.5 1.4 0.1 0.7 0.9 1.3
Hand grip strength (left) 0.9 2.4 8.4 -0.9 1.6 0.0 -1.0 -2.2 2.9 -2.3 0.5 1.5 -0.6 -0.7
Number of treatments/medications taken 0.2 0.3 2.3 -0.2 -1.5 0.0 -0.2 0.1 -0.7 -0.3 -0.0 0.0 0.2 -0.4
Average weekly spirits intake 1.1 1.4 4.9 0.4 1.4 0.0 -0.6 0.0 -2.2 1.1 -1.5 0.3 1.8 0.9
Sensitivity / hurt feelings 0.6 1.0 5.1 0.9 0.3 0.0 -0.5 -0.0 0.0 2.3 -0.9 0.6 1.4 1.5
Frequency of depressed mood in last 2 weeks 0.7 0.9 3.6 0.1 -1.9 0.0 -0.2 0.5 0.6 1.8 0.5 0.2 -0.5 1.5
Hearing difficulty/problems: Yes 0.6 1.0 5.0 0.3 1.1 0.0 0.7 1.0 -0.6 0.3 1.1 -2.2 -0.5 -1.0
Relative age of first facial hair 0.9 1.9 5.9 -1.1 -0.9 0.0 -0.1 0.1 2.1 -0.4 2.4 -1.7 -2.4 -0.5
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 4.3 1.6 -0.4 0.0 1.6 2.1 -0.3 1.3 0.9 -0.3 -0.6 -0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.1 1.0 0.0 0.0 0.3 0.2 0.1 1.0 -0.2 0.1 0.9 0.8
Ever had hysterectomy (womb removed) 0.4 0.5 2.3 0.8 -0.9 0.0 -0.1 -0.2 -0.0 0.9 -0.2 0.7 0.5 1.5
Systolic blood pressure, automated reading 0.2 0.6 2.0 -1.4 0.3 0.0 -0.1 0.0 1.0 -1.4 0.6 -0.3 -1.0 -0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.6 -1.6 -1.1 0.0 -1.1 -0.7 0.4 0.1 -0.5 0.2 -0.3 -0.4
Angina 0.1 0.1 0.3 -0.5 -0.4 0.0 0.4 0.5 0.3 -0.5 0.4 0.0 -0.4 0.2
Medication for hormone replacement therapy 0.8 0.9 3.0 1.1 0.9 0.0 1.7 1.3 0.4 0.1 1.3 -0.0 -0.3 0.9
Vitamin and mineral supplements 1.0 1.4 3.2 1.7 1.3 0.0 -0.2 0.1 -0.9 0.9 -1.1 1.8 1.8 1.3
Supplements: Zinc 0.4 0.4 1.9 -0.6 -1.0 0.0 0.1 -0.4 -0.1 -0.4 0.5 -1.4 -0.4 -0.6
Medication: Co-codamol 0.4 0.5 2.3 -0.2 0.1 0.0 -0.6 -0.2 -0.8 -1.5 -0.9 0.8 0.6 -0.5
Medication: Metformin 0.5 0.6 4.3 0.3 -0.5 0.0 0.1 0.1 2.1 0.8 1.0 0.2 -0.9 0.3
Diabetes (father) 2.2 2.7 8.1 1.4 -0.3 0.0 2.2 2.4 1.6 1.0 2.9 -1.1 -2.0 -0.3
Diabetes (mother) 1.3 1.6 4.8 -0.4 -2.2 0.0 0.8 0.4 1.9 1.1 1.6 -1.5 -1.5 -0.4
Severe depression (siblings) 0.5 0.5 1.8 -1.0 0.7 0.0 -0.3 -0.3 -0.3 -1.4 -0.4 -0.8 -0.1 -1.1
Pack years adult smoking proportion 0.7 1.1 3.5 -0.3 0.3 0.0 -1.0 -0.9 -1.6 -0.1 -1.7 1.0 1.9 0.6
Impedance of leg (right) 0.4 1.7 5.0 2.2 0.8 0.0 1.4 1.9 -1.0 1.7 -0.1 0.9 0.5 1.6
Leg fat-free mass (left) 0.4 2.2 8.2 -2.9 -0.7 0.0 -2.0 -1.9 0.1 -1.8 0.2 -1.1 -0.5 -1.8
Trunk fat percentage 0.3 1.2 8.7 -0.7 -0.2 0.0 -0.1 1.3 -2.9 0.9 -0.4 -1.0 0.7 -0.0
Hand grip strength (right) 0.9 2.4 11.6 -0.3 1.7 0.0 -0.5 -1.9 3.4 -2.3 1.1 0.9 -1.0 -0.8
Townsend deprivation index at recruitment 0.4 0.6 2.7 0.0 -0.9 0.0 0.9 1.6 0.2 0.4 1.0 -0.3 -0.8 0.1
Current tobacco smoking 0.3 0.5 3.1 -0.2 -1.8 0.0 0.4 0.3 -0.3 -0.5 0.5 -1.4 -0.1 0.1
Average weekly fortified wine intake 0.7 0.8 3.2 -0.5 1.8 0.0 -1.4 -1.1 0.2 -0.5 -0.9 0.4 0.6 -1.0
Maternal smoking around birth 0.1 0.1 0.4 0.1 0.5 0.0 -0.3 -0.2 -0.3 0.1 -0.6 0.0 0.6 0.3
Fed-up feelings 0.5 0.9 2.3 -0.8 -0.8 0.0 -1.3 -0.9 0.2 -0.7 -1.5 1.0 1.3 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.9 0.4 -1.3 0.0 1.3 1.7 1.3 1.2 1.1 0.9 -1.0 1.6
Relative age voice broke 0.8 1.2 4.8 0.1 0.5 0.0 0.2 0.4 0.9 0.1 2.2 -1.6 -1.9 -0.9
Taking other prescription medications 0.7 1.1 2.4 -0.4 -0.8 0.0 0.5 1.4 0.3 0.5 1.5 -1.4 -1.6 -1.3
Age when periods started (menarche) 1.4 3.4 15.5 -1.8 -0.1 0.0 0.6 0.6 3.9 -0.4 2.2 -2.5 -2.2 -1.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.9 0.9 -1.3 0.0 -0.4 -0.3 0.2 1.0 0.7 -0.8 0.3 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 7.9 1.6 -1.1 0.0 0.3 0.4 -2.5 1.6 -0.6 0.4 1.2 2.8
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 6.3 0.5 2.5 0.0 0.8 0.4 -0.2 -1.0 -0.3 1.5 0.2 0.4
Qualifications: CSEs or equivalent 2.5 3.3 8.8 0.2 -0.1 0.0 1.9 1.9 2.4 0.4 3.0 -2.6 -2.6 -0.9
Serious illness, injury or assault to yourself 1.0 1.2 2.8 0.8 -0.4 0.0 1.5 1.7 0.9 1.2 1.4 -0.6 -0.9 1.1
High blood pressure 0.4 1.2 4.2 0.7 -1.7 0.0 1.5 2.1 -1.0 0.8 0.7 0.4 -0.3 0.7
Hayfever, allergic rhinitis or eczema 0.4 0.9 4.0 -0.4 0.9 0.0 -0.1 -0.5 1.0 -1.7 0.2 -0.4 -0.7 -2.0
Multivitamins +/- minerals 0.7 0.9 4.7 -0.4 -1.0 0.0 0.5 0.2 0.3 0.2 0.9 -2.2 -0.9 -1.2
Stomach or abdominal pain in last month 0.9 1.1 2.6 0.0 0.4 0.0 1.1 1.4 1.4 -0.0 1.5 -1.2 -1.6 -0.9
Supplements: Glucosamine 3.6 4.7 12.2 -3.3 -0.2 0.0 -3.0 -3.5 -0.1 -2.9 -2.1 -0.8 1.0 -2.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.8 1.3 -1.1 0.0 0.7 0.6 1.2 1.0 1.1 -1.2 -0.3 0.0
Medication: Atenolol 0.2 0.2 0.6 0.8 0.2 0.0 0.3 0.7 0.0 0.5 -0.0 -0.2 0.7 0.2
Medication: Levothyroxine sodium 0.3 0.4 1.7 -1.3 -1.0 0.0 -0.8 -0.3 0.2 -0.5 -0.2 0.6 0.1 -0.8
Sitting height 0.6 4.4 11.7 -3.4 -0.2 0.0 -2.5 -3.4 2.1 -3.2 0.3 -0.0 -1.2 -1.7
Chronic bronchitis/emphysema (father) 0.3 0.4 1.6 -0.9 -1.1 0.0 -0.6 -1.3 0.2 -0.0 -0.5 -0.1 0.3 0.1
High blood pressure (mother) 0.8 1.1 3.1 0.8 0.1 0.0 1.7 1.5 1.8 1.1 1.0 -0.2 -0.9 0.5
Body mass index (BMI) 0.2 0.7 3.1 -1.8 -1.0 0.0 -0.5 0.3 -0.7 0.5 0.4 -1.5 -0.3 -0.8
Impedance of leg (left) 0.3 1.2 3.6 1.9 1.1 0.0 1.2 1.6 -1.2 1.3 -0.0 0.6 0.3 1.2
Leg predicted mass (left) 0.4 2.2 8.4 -2.9 -0.7 0.0 -1.9 -1.9 0.1 -1.7 0.2 -1.1 -0.6 -1.9
Trunk fat mass 0.2 1.0 5.2 -1.6 -0.5 0.0 -0.6 0.5 -2.3 0.3 -0.1 -1.4 0.1 -0.8
Waist circumference 0.3 0.9 4.5 -1.4 -1.1 0.0 -0.7 0.4 -2.1 0.7 -0.3 -1.0 0.5 -0.4
Number of incorrect matches in round 2.0 3.3 9.5 -2.5 0.1 0.0 -2.8 -3.1 0.6 -1.6 -2.1 2.0 0.3 -1.2
Past tobacco smoking 0.3 0.6 3.4 -0.0 -0.8 0.0 -0.6 -0.8 0.9 1.8 0.0 -0.2 -0.1 0.5
Alcohol usually taken with meals 0.2 0.3 0.8 -0.1 0.9 0.0 0.3 0.5 0.0 0.5 0.2 0.7 -0.8 -0.7
Nervous feelings 2.2 4.1 8.8 1.8 -1.5 0.0 2.6 3.0 1.4 3.0 2.5 -1.1 -1.8 1.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 1.3 -0.3 -0.3 0.0 -0.3 0.1 0.5 0.1 -0.1 -0.0 0.1 1.1
Hearing difficulty/problems with background noise 1.1 1.7 5.2 2.0 0.8 0.0 1.3 1.5 -1.4 2.3 0.9 -0.1 0.2 1.6
Hair/balding pattern: Pattern 2 0.6 0.7 1.8 1.2 1.3 0.0 1.4 1.2 -0.8 0.5 0.6 0.2 0.2 0.5
Had menopause 0.5 0.7 2.6 0.6 -0.4 0.0 0.9 1.0 -1.6 1.5 -0.1 0.3 0.3 -0.1
Had other major operations 1.2 1.4 4.4 -1.6 -1.7 0.0 -0.2 -0.0 0.5 -0.9 0.7 -1.8 -1.0 -2.1
Forced vital capacity (FVC) 0.9 3.6 21.2 -1.9 0.2 0.0 -0.9 -1.7 4.6 -1.6 1.8 -0.1 -2.2 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 4.4 1.4 -0.9 0.0 0.4 0.2 -2.0 1.4 -0.2 -0.2 0.8 2.1
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 6.7 1.9 0.1 0.0 1.2 1.3 0.1 1.1 0.6 1.1 0.2 2.6
Qualifications: None of the above 0.7 1.5 3.2 -1.2 -1.4 0.0 -1.8 -1.4 -0.1 0.6 -1.7 1.1 1.6 0.7
Financial difficulties in last 2 years 0.6 0.8 2.3 -0.7 -1.4 0.0 -0.9 -1.2 0.1 -1.5 -0.6 1.2 0.5 0.6
Mouth/teeth dental problems 1.7 2.6 7.8 0.5 -0.1 0.0 2.8 1.6 2.7 -0.6 2.3 -0.9 -2.0 0.1
Heart attack 0.9 1.1 8.3 0.5 -0.9 0.0 -0.2 -0.1 -0.5 0.9 0.1 1.1 0.6 2.9
Allergy 0.5 1.2 6.1 0.2 -1.0 0.0 0.5 0.9 -0.3 2.1 0.5 0.4 0.0 2.5
Pain all over the body in last month 0.8 0.8 4.3 -1.1 -2.1 0.0 -0.4 -0.6 0.2 -1.4 -0.8 0.3 0.2 -0.6
Diabetes (self-reported) 0.2 0.3 1.6 0.5 -0.6 0.0 -0.0 0.0 1.2 0.8 0.6 0.5 -0.2 0.5
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 9.4 -1.3 1.6 0.0 -1.1 -1.8 1.1 -3.1 0.1 -0.9 -0.4 -2.5
Medication: Ramipril 0.3 0.3 1.9 -0.3 -1.4 0.0 0.4 0.3 0.3 -0.8 0.6 -0.3 -0.6 -0.3
Medication: Simvastatin 0.2 0.2 1.2 0.3 -0.9 0.0 -0.3 -0.2 0.0 1.1 0.4 0.5 -0.0 0.3
Fluid intelligence score 0.9 1.9 4.9 0.5 -0.8 0.0 2.1 1.3 0.9 -1.1 2.0 -2.2 -1.1 -1.1
Illnesses of siblings 0.1 0.2 0.6 0.1 -0.8 0.0 0.5 0.2 0.7 0.3 0.1 -0.7 0.0 0.6
Neuroticism score 0.9 1.9 7.7 1.1 -0.0 0.0 0.7 1.5 0.1 2.7 -0.4 0.7 0.9 2.8
Weight 0.3 1.5 7.3 -2.7 -0.9 0.0 -1.4 -0.8 -0.7 -0.8 0.4 -1.5 -0.6 -1.6
Impedance of arm (right) 0.5 2.2 10.4 1.5 1.4 0.0 -0.2 0.6 -3.2 0.3 -1.6 1.3 1.8 1.4
Arm fat percentage (right) 0.3 1.0 5.7 -1.0 -0.5 0.0 -0.3 1.0 -2.4 1.2 -0.2 -1.2 0.4 -0.1
Trunk fat-free mass 0.6 3.7 12.9 -3.6 -0.5 0.0 -2.3 -2.5 1.7 -2.0 0.8 -1.3 -1.4 -2.3
Hip circumference 0.3 1.1 4.2 -2.0 -0.9 0.0 -0.7 0.1 -1.1 -0.1 0.7 -1.8 -0.5 -1.3
Time employed in main current job 0.4 0.5 1.8 -1.1 -0.5 0.0 -1.3 -0.9 -0.2 0.4 -0.6 0.5 0.2 0.1
Alcohol intake versus 10 years previously 1.4 2.1 9.8 -1.9 -1.2 0.0 -1.0 -1.0 3.1 0.1 1.2 0.3 -2.1 -0.7
Father’s age at death 0.3 0.4 2.1 -0.3 0.5 0.0 -0.5 -0.2 -0.6 -0.9 0.2 -0.2 -0.5 -1.4
Worrier / anxious feelings 2.2 4.1 10.9 1.8 0.3 0.0 -0.3 0.6 -1.7 3.3 -1.9 2.9 2.4 3.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 3.7 -0.0 -1.9 0.0 0.1 0.4 0.4 1.1 0.6 0.2 -0.7 1.1
Falls in the last year 0.2 0.3 1.2 0.0 -0.9 0.0 -0.3 -0.3 -0.0 -0.5 -0.7 1.1 0.5 0.1
Hair/balding pattern: Pattern 3 0.6 0.9 3.3 -0.5 -1.8 0.0 -0.7 -1.2 1.7 -0.4 -0.1 0.4 -0.4 0.6
Number of live births 1.6 2.3 6.2 2.5 1.5 0.0 -0.0 -0.1 -2.4 0.2 -1.5 1.1 2.4 1.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.5 18.2 -0.8 0.4 0.0 -0.1 -0.7 4.3 -0.3 2.0 0.0 -2.0 0.4
Pulse rate 2.5 4.1 9.7 -0.6 -2.3 0.0 2.3 2.0 2.5 -1.0 3.1 -2.5 -2.5 -0.9
Happiness 0.3 0.4 1.0 -0.3 -0.8 0.0 0.4 0.3 0.9 -1.0 0.6 0.1 -0.8 -0.2
Noisy workplace 1.7 2.0 6.6 -1.3 2.6 0.0 0.3 0.3 1.2 -1.7 1.5 -1.0 -1.9 -1.8
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.5 1.2 0.5 0.0 1.4 1.2 -1.6 0.7 0.1 -0.5 -0.2 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.7 0.4 -1.9 0.0 0.1 0.1 -0.3 1.1 0.9 -1.7 -0.2 -1.1
Mouth/teeth dental problems: Dentures 1.2 2.1 7.4 -0.6 -0.4 0.0 -2.7 -2.0 -1.7 -0.8 -1.7 1.7 1.3 -0.2
Asthma 0.8 1.5 4.4 0.4 0.8 0.0 -1.1 -1.8 -1.0 -2.1 -1.6 0.5 1.6 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 5.5 -0.1 0.2 0.0 0.1 -0.4 0.6 0.0 0.5 1.6 -0.2 2.4
Medication: Cholesterol lowering 0.5 0.8 2.0 1.3 -0.7 0.0 1.1 0.9 1.0 0.7 0.5 0.4 0.4 1.4
Depression (self-reported) 0.7 0.8 2.8 0.9 -1.5 0.0 0.7 1.3 -0.2 1.7 0.1 -0.0 -0.0 1.1
Medication: Lansoprazole 2.2 2.5 5.7 1.1 1.4 0.0 -1.3 -0.2 -1.7 1.3 -2.1 2.4 2.2 1.5
Prospective memory result 0.4 0.5 2.7 1.6 0.3 0.0 0.6 0.4 -0.6 0.2 0.1 0.9 0.1 0.7
Lung cancer (father) 0.7 0.9 2.8 -0.1 0.8 0.0 -1.0 -0.7 -1.7 -0.3 -1.6 0.9 1.1 -0.2
Illnesses of mother 0.8 1.0 4.5 -1.2 0.4 0.0 -1.1 -1.5 -0.0 -2.1 -0.2 0.3 -0.4 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 12.5 -1.4 0.2 0.0 -0.9 -1.4 3.5 -0.2 1.2 0.6 -1.6 0.5
Pulse wave Arterial Stiffness index 1.2 1.4 3.6 -0.2 0.3 0.0 1.6 1.8 1.6 0.0 1.4 0.4 -1.9 -1.0
Impedance of arm (left) 0.5 2.2 10.0 1.6 1.5 0.0 0.1 0.6 -3.2 0.4 -1.6 1.3 1.8 1.3
Arm fat mass (right) 0.2 1.0 3.6 -1.9 -0.8 0.0 -0.6 0.5 -1.6 0.6 0.2 -1.4 -0.3 -0.8
Trunk predicted mass 0.7 3.8 13.1 -3.6 -0.5 0.0 -2.3 -2.4 1.8 -2.0 0.9 -1.4 -1.5 -2.4
Standing height 0.3 2.9 7.6 -2.7 0.5 0.0 -2.3 -2.5 -0.1 -2.8 -0.1 -0.5 -0.7 -2.2
Length of working week for main job 1.4 1.5 4.6 1.4 -0.2 0.0 1.8 2.1 0.1 1.4 1.4 -1.6 -0.8 -0.5
Exposure to tobacco smoke at home 0.4 0.5 2.6 0.3 -1.6 0.0 0.4 0.3 -0.6 -1.1 0.2 -0.7 -0.2 0.2
Breastfed as a baby 0.5 0.6 1.8 -0.8 -0.9 0.0 -0.6 -0.4 -1.2 -1.0 -0.7 1.3 0.3 0.3
Tense / ‘highly strung’ 0.3 0.5 1.8 0.6 1.0 0.0 1.1 1.3 0.2 0.3 0.4 0.1 -0.2 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.1 -0.6 -0.4 0.0 -0.7 -0.6 0.8 -0.6 -0.2 0.3 0.3 1.0
Hair/balding pattern: Pattern 4 0.2 0.5 1.5 0.2 0.2 0.0 -1.0 -0.8 -1.2 -0.2 -1.2 0.5 1.0 -0.2
Birth weight of first child 0.3 0.6 2.3 0.7 -0.2 0.0 0.0 0.1 -1.1 1.3 -0.5 -0.1 0.8 1.5
Peak expiratory flow (PEF) 0.3 0.7 5.7 0.7 0.4 0.0 0.1 -0.4 2.4 0.3 0.7 0.2 -0.3 0.6
Pulse wave reflection index 0.8 0.9 4.0 -0.3 1.4 0.0 0.8 0.6 2.0 -0.1 0.5 0.0 -1.3 -1.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 4.0 -0.0 2.0 0.0 -0.3 0.5 -0.1 0.5 -0.2 -0.1 0.1 -0.2
Loud music exposure frequency 1.1 1.2 5.9 2.4 0.5 0.0 1.2 1.0 -1.0 0.8 1.3 0.1 -0.3 1.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 2.5 0.1 1.1 0.0 -0.4 -0.7 -1.2 -1.6 -0.3 0.3 -0.0 -1.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 4.3 -0.3 -0.7 0.0 -0.2 1.1 -1.8 1.4 -0.0 -2.1 0.1 -0.2
Blood clot in the leg (DVT) 0.2 0.2 0.8 0.1 -0.8 0.0 -0.5 0.2 -0.2 0.9 -0.3 0.1 -0.0 -0.6
Medication: Paracetamol 0.6 0.9 2.7 -1.6 -0.5 0.0 -1.6 -1.2 1.0 -0.4 -0.8 1.2 0.1 0.6
Headache pain in last month 0.7 1.3 3.0 -0.0 -1.6 0.0 -1.4 -0.8 -1.7 1.2 -0.9 1.5 0.9 0.5
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.1 -1.0 1.1 0.0 -1.4 -1.4 -0.3 0.3 -0.9 0.1 0.1 -0.6
Glaucoma (self-reported) 0.7 0.9 4.3 -0.4 -1.4 0.0 -0.7 -0.6 -2.1 -0.5 -0.7 -0.6 0.7 -0.7
Gout (self-reported) 1.1 1.4 7.2 0.2 -0.6 0.0 -0.7 -0.4 -2.7 0.4 -1.9 0.8 1.8 0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 3.0 0.2 0.1 0.0 -0.8 -0.4 -0.3 0.4 -0.6 1.7 0.7 0.5
Medication: Amlodipine 1.8 2.6 6.3 -1.5 -2.4 0.0 0.2 0.6 2.5 0.3 1.9 -2.1 -2.0 -1.2
Medication: Ventolin 100micrograms inhaler 2.4 3.0 10.3 -1.0 -0.4 0.0 -3.0 -3.2 -0.9 -1.1 -2.3 0.3 2.3 0.0
Birth weight 0.4 0.9 3.8 0.3 0.3 0.0 -0.6 -0.4 -1.9 0.3 -1.5 0.5 1.5 -0.3
Chronic bronchitis/emphysema (mother) 1.4 1.6 4.4 1.4 -0.8 0.0 1.5 1.9 0.0 2.1 0.8 -0.3 -0.6 1.9
High blood pressure (siblings) 0.2 0.3 0.9 -0.7 0.9 0.0 -0.6 0.3 -0.6 0.1 -0.1 0.6 -0.3 -0.6
Forced vital capacity (FVC), Best measure 0.9 3.2 14.3 -2.5 0.1 0.0 -1.6 -2.3 3.8 -1.2 1.1 0.3 -1.8 -0.6
Body fat percentage 0.3 1.1 6.9 -0.8 -0.5 0.0 0.0 1.3 -2.6 1.1 -0.2 -1.0 0.5 -0.1
Leg fat percentage (right) 0.2 0.8 3.4 -1.1 -1.1 0.0 -0.2 0.9 -1.8 1.4 -0.2 -0.9 0.3 0.0
Arm fat-free mass (right) 0.5 2.6 8.5 -2.9 -0.9 0.0 -1.3 -1.5 1.4 -1.5 1.2 -1.5 -1.6 -2.2
Exposure to tobacco smoke outside home 1.8 2.4 6.3 -1.8 -0.0 0.0 -1.9 -2.0 0.6 -2.4 -0.5 -1.6 -0.0 -2.5
Comparative body size at age 10 1.2 3.2 8.9 -1.9 0.0 0.0 -2.6 -3.0 -0.5 -1.7 -2.3 -0.4 1.8 -2.0
Number of full brothers 1.1 1.4 4.9 2.2 0.5 0.0 0.6 0.2 -2.0 0.1 -0.8 0.6 2.1 0.8
Worry too long after embarrassment 1.7 2.8 7.5 2.5 1.2 0.0 2.4 2.7 -0.6 2.7 0.5 -0.5 0.7 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 3.5 0.0 1.9 0.0 0.8 1.3 0.8 0.5 0.2 0.4 -0.4 0.5
Wheeze or whistling in the chest in last year 1.3 2.3 5.1 -2.3 -1.7 0.0 -1.5 -1.5 0.4 -2.2 0.1 -1.7 -0.4 -2.2
Number of children fathered 0.6 0.7 2.2 -0.7 0.4 0.0 0.8 0.1 0.1 -1.5 0.4 -1.5 -0.6 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.7 1.0 -0.7 0.0 1.0 1.0 -0.3 1.3 0.7 -0.2 -0.7 0.3
Age at first live birth 0.3 0.5 2.6 0.4 1.6 0.0 0.5 0.3 -0.2 -0.8 -0.2 -0.6 0.2 -0.9
Pulse wave peak to peak time 1.3 1.5 3.5 0.2 -0.1 0.0 -1.7 -1.8 -1.9 -0.1 -1.4 -0.1 1.9 1.1
Health satisfaction 0.2 0.3 1.0 0.5 -1.0 0.0 0.4 0.6 -0.8 -0.6 -0.4 0.0 0.1 -0.4
Shortness of breath walking on level ground 0.1 0.2 0.7 0.4 -0.2 0.0 -0.3 0.1 -0.1 -0.0 -0.9 -0.3 0.7 -0.0
Qualifications: College or University degree 0.3 0.8 1.9 0.1 1.1 0.0 1.1 1.4 -1.1 -0.1 0.6 -0.0 -1.3 -1.2
Eye problems/disorders: None of the above 0.6 0.7 1.6 -0.7 0.7 0.0 1.0 0.8 1.2 -1.0 0.9 -0.6 -1.2 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.0 -0.4 -1.0 0.0 0.6 0.5 0.2 -0.6 0.4 0.5 -0.9 0.2
Emphysema/chronic bronchitis 0.2 0.2 0.5 -0.1 -0.4 0.0 -0.5 -0.2 -0.5 0.7 -0.7 0.3 0.5 -0.6
Medication for pain relief, constipation, heartburn 0.8 1.4 4.5 0.9 2.1 0.0 1.4 1.1 -0.2 -0.5 0.4 -1.5 -0.2 -2.0
Neck or shoulder pain in last month 0.1 0.2 0.7 0.6 -0.6 0.0 -0.3 -0.1 -0.5 0.2 -0.3 0.4 0.4 0.8
Medication: Blood pressure 1.5 2.7 8.8 2.1 -1.2 0.0 2.8 3.0 0.1 1.0 1.4 0.7 -0.6 1.9
Angina (self-reported) 0.3 0.4 1.1 -0.7 -0.4 0.0 0.8 0.8 0.6 -0.7 0.9 -0.4 -1.0 -0.2
Migraine (self-reported) 1.4 1.8 5.2 1.3 1.2 0.0 -0.2 0.1 -1.5 1.5 -0.9 2.2 0.9 2.3
Medication: Ibuprofen 0.7 0.9 4.9 -0.2 -0.2 0.0 -0.1 -0.5 0.4 0.2 -0.3 2.0 0.4 2.2
Medication: Allopurinol 1.2 1.5 4.3 -0.4 0.6 0.0 -0.9 -0.8 -1.9 0.4 -2.1 2.0 1.6 0.2
Medication: Omeprazole 1.5 1.8 5.3 1.8 -1.1 0.0 2.3 1.9 -0.2 0.7 1.4 -1.6 -0.7 -0.6
Medication: Seretide 50 evohaler 0.5 0.6 1.3 -1.1 -0.2 0.0 -1.0 -1.2 1.1 -0.7 -0.8 0.4 0.4 -0.1
Mean time to correctly identify matches 0.6 1.2 3.5 1.4 0.7 0.0 0.1 0.1 -1.0 1.9 -0.7 1.8 1.1 0.7
Heart disease (mother) 0.3 0.4 1.8 0.6 1.3 0.0 -0.3 -0.1 0.8 0.7 0.2 0.9 -0.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.0 1.0 1.4 0.0 0.3 0.9 -1.0 0.2 -0.7 -0.3 0.8 -0.5
Whole body fat mass 0.2 0.9 4.6 -1.5 -0.7 0.0 -0.5 0.6 -2.1 0.4 -0.0 -1.1 0.1 -0.7
Leg fat mass (right) 0.2 0.8 2.8 -1.6 -1.2 0.0 -0.6 0.4 -1.7 0.4 0.1 -1.2 -0.0 -0.8
Arm predicted mass (right) 0.4 2.2 7.6 -2.8 -0.6 0.0 -1.4 -1.6 1.0 -1.5 0.8 -1.4 -1.1 -2.1
Pulse rate, automated reading 0.9 2.9 7.8 -1.3 -1.7 0.0 1.6 1.3 1.8 -1.2 2.2 -2.8 -2.0 -1.1
Alcohol intake frequency. 0.7 1.7 11.2 0.3 -1.1 0.0 0.2 -0.1 3.4 1.0 1.5 0.1 -1.4 0.9
Comparative height size at age 10 0.1 0.5 2.1 -0.5 0.6 0.0 -0.4 -0.3 -1.4 -0.8 -0.4 -0.3 0.2 -1.3
Number of full sisters 0.2 0.2 0.7 -0.3 0.8 0.0 -0.1 -0.2 0.3 0.1 0.3 -0.8 -0.6 -0.6
Suffer from ‘nerves’ 0.6 0.9 2.5 -0.0 -1.6 0.0 0.7 1.1 0.6 1.0 1.3 -1.3 -0.7 1.0
Overall health rating 0.3 0.7 2.4 0.7 -0.8 0.0 0.8 1.5 0.3 0.9 0.8 -0.9 -0.5 0.8
Chest pain or discomfort 0.8 1.1 3.3 -1.8 -0.2 0.0 -1.8 -1.7 0.0 -1.1 -0.6 0.9 -0.1 -0.5
Had major operations 0.5 0.6 3.9 -1.1 -2.0 0.0 -0.8 -0.5 -0.1 0.2 -0.3 -0.0 -0.1 0.3
Age at last live birth 0.5 0.7 1.7 0.8 0.6 0.0 1.3 1.0 -0.1 -0.9 0.8 -1.3 -0.8 -0.6
Family relationship satisfaction 0.7 0.9 2.8 -1.7 -0.2 0.0 -1.6 -1.5 0.1 -1.0 -0.6 0.3 -0.3 -0.9
Leg pain on walking 1.2 1.5 4.0 -1.5 -0.8 0.0 -2.0 -1.7 -0.4 -0.3 -1.9 1.2 1.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.7 1.3 -0.0 0.0 1.2 1.2 1.1 1.1 1.2 -0.1 -0.6 1.0
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.5 0.4 0.7 0.0 0.4 -0.0 0.6 0.2 0.2 -0.3 -0.2 -0.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.5 0.8 1.2 0.0 0.3 0.2 -0.0 0.5 0.2 0.6 -0.4 0.6
Medication: Aspirin 0.7 1.0 7.8 -1.2 -2.8 0.0 -0.4 0.3 -0.3 0.5 -0.4 0.0 0.3 0.8
Supplements: Vitamin C 0.3 0.4 1.8 -0.3 0.3 0.0 0.2 -0.4 0.4 -1.3 0.4 -1.2 -0.4 -0.2
Knee pain experienced in last month 1.4 2.1 6.0 -2.0 -1.3 0.0 -2.4 -2.4 0.7 -1.3 -1.2 -0.8 0.2 -1.3
Hypertension (Self-reported) 0.5 1.3 4.8 0.7 -1.7 0.0 1.6 2.2 -0.9 0.9 0.7 0.7 -0.5 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 6.1 -0.9 -0.0 0.0 -2.5 -2.1 -0.4 -1.0 -1.6 0.9 1.4 0.4
Illnesses of father: Heart disease 0.5 0.7 2.6 0.9 0.6 0.0 -0.1 0.2 -1.1 1.6 -0.7 0.7 1.0 0.6
Illnesses of siblings: Diabetes 1.0 1.3 3.6 -1.9 -0.3 0.0 -1.9 -1.9 -0.0 -1.3 -0.4 0.3 0.1 -1.1
Smoking status: Previous 0.5 0.7 4.1 -0.6 0.8 0.0 -0.3 -0.3 -0.5 -2.0 -0.4 1.2 0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 5.2 -1.0 1.8 0.0 -2.3 -2.1 -0.8 -0.4 -1.9 1.0 1.2 -0.9
Whole body fat-free mass 0.6 3.2 11.4 -3.4 -0.6 0.0 -2.2 -2.3 1.0 -1.9 0.6 -1.4 -1.1 -2.2
Leg fat-free mass (right) 0.5 2.8 9.9 -3.1 -0.4 0.0 -2.1 -2.1 0.2 -2.2 0.2 -1.3 -0.7 -2.2
Arm fat percentage (left) 0.2 1.0 5.3 -1.2 -0.5 0.0 -0.3 0.9 -2.3 1.1 -0.2 -1.2 0.3 -0.3
Average weekly red wine intake 0.2 0.3 1.2 1.1 -0.2 0.0 0.6 0.5 -0.9 -0.1 0.5 -0.8 0.1 -0.3
Handedness (chirality/laterality): Left-handed 0.5 0.5 1.7 -0.9 1.3 0.0 -0.6 -0.1 -0.3 1.0 -1.0 0.6 0.6 -0.6
Mood swings 0.5 0.9 2.8 -1.1 0.9 0.0 -1.7 -0.9 0.3 0.4 -1.3 0.8 0.8 1.0
Loneliness, isolation 0.7 0.9 3.8 0.3 -0.8 0.0 0.1 0.9 -0.0 1.9 -0.4 0.7 0.3 1.9
Long-standing illness, disability or infirmity 0.7 1.0 3.0 1.4 -1.6 0.0 1.0 1.7 -0.3 1.3 0.9 0.3 -0.3 0.4
Ever had bowel cancer screening 1.3 1.5 4.2 2.1 0.7 0.0 1.2 1.7 -1.4 1.5 -0.9 0.3 1.1 1.2
Diabetes diagnosed by doctor 0.2 0.4 1.2 0.3 -0.6 0.0 0.2 0.3 1.1 1.1 0.6 0.0 -0.4 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.8 -0.3 -0.7 0.0 -0.5 -0.6 -0.0 -0.9 -0.4 -0.5 0.2 0.2
Friendships satisfaction 0.1 0.1 0.4 0.5 -0.3 0.0 -0.2 -0.0 0.1 0.6 -0.1 0.3 -0.2 0.1
Qualifications: nursing, teaching 0.5 0.8 5.7 0.3 2.4 0.0 -0.5 -0.8 -0.4 -0.9 -0.0 -0.9 0.4 -0.6
Commuting to job workplace: Walk 1.2 1.3 2.7 -0.5 0.5 0.0 -1.6 -1.6 -0.7 -1.4 -1.3 1.5 1.3 0.6
Eye problems/disorders: Cataract 0.3 0.4 1.8 0.8 -0.1 0.0 0.8 0.4 -0.2 0.5 0.3 0.6 0.1 1.4
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 10.2 -0.7 0.9 0.0 -2.8 -2.3 -1.6 1.1 -3.2 1.6 2.5 -0.2
Medication for cholesterol 0.1 0.1 0.3 0.5 0.1 0.0 0.2 -0.2 0.1 -0.1 -0.6 -0.1 0.5 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 -0.0 -0.7 0.0 -0.1 -0.3 -0.2 0.5 0.1 0.6 -0.3 0.1
Back pain experienced in last month 0.3 0.4 1.9 -0.6 0.3 0.0 -1.4 -1.0 -0.2 -0.2 -0.6 -0.2 0.8 0.6
Mineral and other dietary supplements 3.0 4.0 12.0 2.9 0.6 0.0 2.0 2.9 -0.7 3.5 1.1 1.7 -0.5 2.4
Breast cancer (self-reported) 0.4 0.4 3.1 0.3 -1.8 0.0 0.5 0.3 0.1 0.7 -0.5 -0.6 0.4 0.0
Asthma (self-reported) 0.8 1.6 4.4 0.3 0.9 0.0 -1.2 -2.1 -0.8 -2.1 -1.7 0.6 1.6 -0.3
Osteoporosis (self-reported) 0.7 0.9 3.1 -0.3 -1.8 0.0 -0.7 -0.5 -0.9 -0.7 -0.9 -0.8 0.7 -1.6
Osteoarthritis (self-reported) 0.5 0.6 2.1 -0.8 -1.0 0.0 -1.4 -1.0 0.4 0.0 -0.6 -1.1 -0.0 -0.5
Medication: Aspirin 0.7 0.9 6.0 -1.5 -2.4 0.0 -0.8 -0.1 -0.1 0.3 -0.6 0.5 0.3 0.6
Medication: Gliclazide 0.2 0.2 0.7 0.2 -0.3 0.0 0.4 0.5 0.7 -0.5 0.9 -0.1 -0.6 0.3
Illnesses of father: None of the above (group 1) 0.3 0.4 1.1 -0.6 -0.4 0.0 -0.8 -0.5 0.9 -1.1 -0.2 0.0 -0.5 -0.9
Smoking status: Current 0.3 0.5 3.1 -0.2 -1.8 0.0 0.3 0.3 -0.3 -0.6 0.4 -1.4 -0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 6.6 -1.8 -0.9 0.0 -1.5 -1.6 2.6 0.5 -0.2 -0.2 -0.2 -0.1
Whole body water mass 0.6 3.1 11.4 -3.4 -0.6 0.0 -2.1 -2.2 1.1 -1.9 0.7 -1.4 -1.2 -2.1
Leg predicted mass (right) 0.5 2.9 9.9 -3.1 -0.4 0.0 -2.1 -2.2 0.2 -2.2 0.2 -1.4 -0.7 -2.2
Arm fat mass (left) 0.3 1.0 3.8 -2.0 -0.7 0.0 -0.7 0.4 -1.6 0.6 0.1 -1.6 -0.2 -1.0
Number of self-reported non-cancer illnesses 0.2 0.4 2.0 0.8 -0.8 0.0 0.1 0.6 -1.4 0.2 0.1 0.7 0.3 0.5
Average weekly champagne plus white wine intake 1.6 2.2 7.5 1.4 -0.0 0.0 0.1 1.0 -2.3 2.7 -0.9 1.0 1.4 2.0
Miserableness 1.3 2.2 7.1 1.7 -0.2 0.0 0.7 1.5 -1.4 2.5 -0.4 1.5 1.0 2.7
Guilty feelings 0.8 1.1 3.3 -0.6 -1.0 0.0 -1.4 -1.1 -0.8 0.5 -1.7 -0.6 1.8 0.8
Wears glasses or contact lenses 0.6 0.7 1.8 0.1 1.3 0.0 0.8 0.8 -1.1 -0.4 0.7 -0.9 -0.4 -1.2
Ever taken oral contraceptive pill 1.1 1.2 4.7 0.6 0.9 0.0 2.2 1.6 1.0 -0.2 1.7 -0.3 -1.1 -0.4
Hearing aid user 0.3 0.3 1.3 -0.4 1.1 0.0 -0.4 -0.2 -0.3 0.1 -0.4 1.0 -0.3 -0.3
Mother’s age at death 0.2 0.2 0.9 0.3 -0.1 0.0 -0.1 -0.1 -0.1 0.9 -0.4 0.8 0.5 0.4
Financial situation satisfaction 0.6 0.8 5.4 -0.1 -2.3 0.0 0.1 -0.1 1.1 -0.4 0.7 -0.4 -0.9 0.4
Tinnitus: Yes, now most or all of the time 1.2 1.5 4.5 -0.6 0.2 0.0 1.0 1.1 1.6 -0.4 2.0 -0.9 -2.1 -1.0
Commuting to job workplace: Public transport 0.8 1.0 3.3 0.2 -1.8 0.0 1.2 1.1 -1.3 -0.7 0.3 -1.3 0.2 -0.9
Eye problems/disorders: Glaucoma 0.5 0.6 3.4 0.5 -1.8 0.0 0.2 0.0 -1.4 0.5 -0.2 -0.2 0.3 0.1
Medication: Blood pressure 0.2 0.4 1.5 -1.1 -0.7 0.0 -0.7 0.2 -0.7 -0.0 0.3 -0.4 -0.5 -1.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.1 0.4 -0.8 0.0 -0.1 -0.6 1.1 0.2 -0.1 0.4 0.2 0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 6.0 -1.5 1.1 0.0 -0.2 -1.3 0.9 -2.5 -0.3 -0.2 -0.3 -1.3
High cholesterol (Self-reported) 0.5 0.8 2.4 0.8 -1.6 0.0 0.8 0.8 0.3 1.1 0.1 1.0 0.3 1.4
Medication: Bendroflumethiazide 0.7 1.1 2.8 -0.6 -0.6 0.0 1.2 1.5 -1.2 -0.7 1.1 -1.7 -0.9 -1.0
Medication: Paracetamol 0.6 1.0 4.4 -2.1 -0.2 0.0 -1.5 -1.2 0.8 -0.5 -0.9 1.1 -0.2 -0.1
Medication: Lisinopril 1.2 1.5 5.8 1.0 -1.1 0.0 0.3 0.5 -1.9 1.0 -0.6 2.4 0.7 1.7
Medication: Atorvastatin 2.3 2.8 10.1 1.8 -1.8 0.0 1.1 1.7 -0.2 2.7 -0.1 1.6 0.5 3.2
Illnesses of father: High blood pressure 0.5 0.6 2.7 -0.4 0.2 0.0 1.2 1.6 -0.7 1.1 0.6 -0.7 -0.3 -0.3
Alcohol drinker status: Never 1.4 1.6 4.7 -1.7 -1.4 0.0 -2.2 -2.0 -0.4 -1.1 -1.1 0.1 0.5 -1.1
Ever smoked 0.3 0.5 1.6 0.4 0.7 0.0 0.8 1.1 -1.3 -1.2 0.3 -0.1 -0.0 0.2
Basal metabolic rate 0.5 2.7 10.5 -3.2 -0.7 0.0 -1.9 -1.9 0.7 -1.6 0.7 -1.5 -1.1 -2.1
Leg fat percentage (left) 0.2 0.8 3.4 -1.4 -0.8 0.0 -0.3 0.8 -1.8 1.0 -0.0 -1.1 -0.0 -0.4
Arm fat-free mass (left) 0.5 2.6 9.5 -3.1 -0.9 0.0 -1.6 -1.8 1.2 -1.6 0.9 -1.5 -1.3 -2.0
Number of operations (self-reported) 1.0 1.4 5.0 -2.2 -2.1 0.0 -0.9 -0.3 0.2 -1.2 -0.0 -1.4 -0.3 -1.4
Average weekly beer plus cider intake 0.7 1.0 3.7 -0.7 -0.4 0.0 0.8 0.4 0.3 -1.9 1.0 -1.3 -1.0 -1.3
Irritability 0.4 0.7 2.1 -0.7 -0.2 0.0 -1.2 -0.9 -0.8 -0.6 -1.4 0.8 1.0 0.4
Risk taking 1.9 2.7 8.8 -2.1 0.6 0.0 0.8 0.2 2.6 -1.8 2.0 -0.9 -3.0 -0.8
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.3 0.5 1.0 0.0 0.3 0.3 -1.5 -0.3 -1.2 0.1 1.2 -1.0
Fractured/broken bones in last 5 years 0.1 0.1 0.7 -0.3 0.2 0.0 0.1 0.6 0.8 0.2 -0.3 0.5 0.3 0.1
Age started oral contraceptive pill 1.3 1.6 4.5 1.7 1.0 0.0 2.1 2.0 -0.4 1.3 0.9 0.8 -0.2 1.6
Diastolic blood pressure, automated reading 0.8 2.6 6.4 -2.3 -0.0 0.0 -0.0 0.1 1.8 -2.0 2.1 -1.4 -2.5 -1.7
Ever depressed for a whole week 0.5 0.6 1.5 1.0 -0.3 0.0 0.9 1.0 0.5 1.2 0.6 0.7 -0.1 1.2
Unable to work because of sickness or disability 0.6 0.7 1.8 0.9 -0.9 0.0 1.3 1.4 1.1 0.4 0.8 -0.9 -0.5 -0.2
Commuting to job workplace: Cycle 1.6 1.9 4.7 0.4 0.5 0.0 -1.3 -1.4 -2.0 -0.9 -2.2 1.9 2.0 0.1
Myopia 1.2 1.8 9.8 -0.1 -0.3 0.0 0.4 0.3 -3.1 -1.4 -1.6 -0.7 1.9 -1.0
Vascular/heart problems diagnosed by doctor 0.4 1.2 3.3 -0.6 1.8 0.0 -1.3 -1.8 0.9 -0.5 -0.9 -1.1 0.5 -1.2
Cholesterol lowering medication 1.0 1.5 6.0 0.2 -1.6 0.0 -0.4 0.1 -0.6 2.4 -0.1 1.6 -0.0 2.1
Medication: Omeprazole (e.g. Zanprol) 1.3 1.5 3.5 1.4 -1.7 0.0 1.9 1.6 -0.1 0.2 1.4 -1.5 -1.0 -0.8
Pain experienced in last month 0.6 1.0 8.3 1.0 2.9 0.0 1.0 0.8 0.2 0.2 0.2 -0.2 -0.1 0.1
Supplements: Calcium 1.2 1.4 5.2 -1.1 -1.5 0.0 0.4 0.3 0.3 -1.2 0.4 -2.0 -0.7 -2.3
Basal cell carcinoma (self-reported) 0.2 0.3 1.2 0.0 -0.9 0.0 -0.6 -1.1 -0.2 -0.2 0.1 0.5 -0.0 0.1
Heart attack/myocardial infarction (self-reported) 0.9 1.1 8.9 0.4 -0.9 0.0 -0.3 -0.1 -0.3 1.0 0.1 1.1 0.6 3.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.2 -0.2 -1.1 0.0 -0.8 -0.2 0.0 0.6 -0.4 0.2 0.0 -0.6
Heart disease (siblings) 0.6 0.8 1.8 1.3 -0.1 0.0 -0.5 -0.7 -0.7 0.7 -0.9 1.2 1.1 1.3
Alcohol drinker status: Previous 3.4 3.9 9.9 2.9 1.0 0.0 3.1 2.6 1.9 1.9 2.3 0.0 -1.4 1.3
Pack years of smoking 0.5 0.7 2.4 -0.2 0.3 0.0 -0.7 -0.6 -1.4 -0.4 -1.3 0.6 1.5 0.4
Impedance of whole body 0.4 1.9 6.3 2.1 1.3 0.0 0.8 1.3 -2.5 0.8 -1.0 1.1 1.3 1.4
Leg fat mass (left) 0.3 1.0 3.7 -1.9 -1.1 0.0 -0.7 0.3 -1.6 0.1 0.2 -1.3 -0.3 -1.2
Arm predicted mass (left) 0.5 2.3 8.6 -2.9 -0.7 0.0 -1.7 -1.7 1.2 -1.3 1.0 -1.3 -1.3 -1.9