Hub : Genes

AKTIP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.12 0.029 1.0e-08 0.090 0.032 0.084 0.022 0.076 4.5e-11 7.6e-05 1.9e-10 1e-03 1.4e-09
2 GTEx Brain Frontal Cortex BA9 0.29 0.104 3.3e-03 0.043 NA 0.071 NA 0.037 2.7e-02 NA 6.3e-03 NA 3.7e-02
3 GTEx Testis 0.19 0.076 7.8e-03 0.000 NA 0.005 NA 0.002 3.1e-01 NA 1.9e-01 NA 2.4e-01
4 YFS Blood 0.19 0.026 0.0e+00 0.270 0.286 0.295 0.297 0.298 2.4e-88 1.5e-94 5.3e-98 6e-99 3.3e-99
5 TCGA Ovarian Tumor 0.12 0.058 5.6e-03 0.003 0.021 0.063 NA 0.040 1.6e-01 3.5e-03 7.9e-07 NA 7.8e-05
6 TCGA Prostate Tumor 0.12 0.043 2.4e-03 0.002 0.009 -0.001 NA 0.013 1.9e-01 2.1e-02 4.8e-01 NA 7.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 0.5 -0.0 0.2 -0.5 -0.1 -0.8
Alzheimer’s Disease (in father) 1.0 1.1 3.1 0.2 0.8 0.6 -1.8 0.6 -1.4
Alzheimer’s Disease (including proxy) 0.4 0.5 1.5 0.2 -0.2 0.3 -1.2 0.3 -1.2
Crohns Disease (2017) 2.1 4.6 15.9 0.2 -0.8 -2.0 -2.6 -0.1 -4.0
Irritable Bowel Disease (IBD) 0.6 1.4 3.1 0.3 -0.8 -1.3 -1.8 -0.3 -1.7
Ulcerative Colitis (UC) 0.1 0.2 0.7 -0.1 -0.6 -0.1 0.1 -0.3 0.8
Major Depression (MDD) 1.3 1.6 4.4 0.9 0.2 2.1 -0.3 2.1 -0.0
Reaction Time 0.3 0.6 2.6 -0.9 -1.6 -0.2 0.2 0.2 0.1
Verbal and Numeric Reasoning (VNR) 7.1 17.3 51.6 -5.4 -3.4 3.2 7.2 -0.9 0.7
Breast Cancer 1.8 4.3 24.0 0.2 0.9 4.9 -0.7 -0.5 0.7
Ovarian Cancer 2.0 2.7 4.5 -2.0 -2.1 0.2 1.3 -1.6 -1.9
Prostate Cancer 0.6 0.9 2.1 -1.4 -0.9 -0.8 1.2 0.6 -0.1
Age at First Birth 1.5 2.2 7.5 -1.7 -2.7 -0.8 0.7 -0.3 -1.3
Bipolar Disorder 1.4 1.4 2.5 -1.6 -0.5 -1.3 1.6 -1.3 0.0
Body Mass Index (BMI) (2010) 9.7 13.6 73.5 -1.5 -0.8 8.6 1.8 1.4 0.0
Coronary Artery Disease (CAD) 1.2 1.5 2.7 1.6 1.0 1.6 -1.6 -0.4 0.0
Crohns Disease (2012) 0.6 1.0 4.6 -0.6 0.1 0.9 2.1 -0.5 0.0
Mean Putamen Volume 0.2 0.2 0.6 0.0 0.0 0.8 0.4 0.1 0.7
Fasting Glucose 0.4 0.5 1.3 1.1 -0.0 0.5 -1.1 -0.1 0.1
HbA1C 0.7 0.8 2.0 0.3 -0.5 0.7 -1.4 -1.1 -0.8
HDL Cholesterol 0.3 0.6 2.1 0.1 -0.1 -1.5 -0.3 -0.8 0.6
LDL Cholesterol 0.8 1.2 3.8 -0.7 -0.8 1.2 -0.9 -0.5 -2.0
Lupus 1.5 2.3 5.4 1.8 2.1 -0.7 -2.3 -0.1 -0.1
Neuroticism 0.4 0.7 2.1 -1.0 -0.0 0.8 0.1 0.5 -1.4
Primary Biliary Cirrhosis 0.2 0.2 0.9 0.2 0.3 -1.0 -0.3 -0.6 0.0
Rheumatoid Arthritis 0.3 0.4 0.8 -0.6 -0.5 0.8 0.7 0.9 0.2
Schizophrenia 0.4 0.9 2.2 -0.7 0.2 -1.3 0.3 -1.5 -1.0
Triglycerides 1.2 2.0 5.1 -0.2 -0.8 2.3 -0.6 1.8 -1.7
Type 2 Diabetes (T2D) 2.5 3.0 9.3 2.2 1.2 3.0 -1.4 0.4 0.0
Ulcerative Colitis 0.3 0.5 1.7 0.6 1.3 -0.9 -0.4 0.2 0.0
Blood Eosinophil Count 0.2 1.3 2.2 1.0 1.1 0.9 -1.5 1.3 -1.2
Blood Platelet Count 0.5 5.6 12.3 2.3 3.5 -1.5 -2.5 -2.3 -1.5
Blood Red Count 0.2 1.8 4.0 2.0 1.1 0.3 -2.0 1.3 0.2
Blood White Count 0.3 2.1 4.8 1.9 0.2 2.2 -2.0 -0.1 0.1
Heel T-Score 0.2 1.8 5.1 1.9 0.7 0.2 -2.3 0.0 -1.1
BMI 10.4 62.0 357.2 -1.0 -2.5 18.9 2.0 0.2 1.8
Height 3.2 63.6 207.4 -9.4 -7.1 3.1 14.4 -0.0 5.1
Waist Hip Ratio (WHR) 2.2 10.0 38.5 3.8 1.7 -1.0 -6.2 -1.0 -1.3
Systolic Blood Pressure 0.5 2.8 6.5 -0.4 -1.6 -0.3 -1.6 -2.5 -2.1
Smoking Status 0.5 1.3 3.4 0.9 0.2 1.8 -1.4 1.2 -0.1
Allergy or Eczema 0.9 2.3 8.0 -1.3 -1.4 1.2 -0.3 -0.6 -2.8
Cardiovascular Disease 1.6 5.2 14.1 1.8 1.0 3.3 -3.8 0.2 -1.4
Hypothyroidism (self reported) 0.2 0.4 1.2 -0.3 -0.7 1.1 -0.1 -0.2 -0.6
Respiratory disease 0.7 1.6 4.8 0.3 -1.1 2.2 -1.2 0.5 -1.4
Type 2 Diabetes (T2D) 9.3 17.4 29.0 5.4 3.8 4.4 -5.0 3.7 1.7
Lung FEV1/FVC ratio 0.5 2.7 6.1 -1.9 -2.5 0.7 1.0 1.1 -1.9
Lung FVC 0.4 2.2 6.1 1.6 0.7 -2.5 -1.9 0.3 -0.6
Neuroticism 0.1 0.2 0.4 0.1 0.2 0.1 0.5 0.6 0.5
Chronotype (morning person) 2.6 6.0 26.4 -1.3 -2.3 5.1 0.5 -0.5 -1.3
Hair Pigment 0.0 0.1 0.3 -0.1 0.0 -0.5 0.4 0.0 -0.1
Tanning 0.0 0.5 2.4 0.0 -0.2 0.3 -0.4 -1.6 -0.1
Hand grip strength (left) 0.6 1.5 5.1 1.8 0.5 0.7 -2.2 -0.1 -0.4
Number of treatments/medications taken 1.0 1.9 3.6 -0.7 -0.2 -1.9 1.6 1.2 1.7
Average weekly spirits intake 2.7 3.4 13.4 1.8 0.1 -3.7 -0.8 -0.4 1.7
Sensitivity / hurt feelings 0.4 0.7 1.6 -0.7 -0.3 -0.7 1.3 -0.7 1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 3.2 -0.1 -0.2 -1.8 0.0 -0.9 -0.3
Hearing difficulty/problems: Yes 2.9 4.4 11.8 2.8 2.5 0.7 -3.4 0.1 0.0
Relative age of first facial hair 0.7 1.5 6.7 0.4 0.7 2.6 -0.5 0.4 -1.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.6 -0.7 0.6 0.3 0.3 0.3 -0.0
Ever used hormone-replacement therapy (HRT) 0.4 0.6 2.0 -0.0 -0.5 -0.6 1.4 0.6 0.7
Ever had hysterectomy (womb removed) 2.1 2.4 4.5 -1.8 -2.1 1.9 1.5 0.5 0.8
Systolic blood pressure, automated reading 0.6 1.8 3.2 0.9 1.5 -1.8 0.3 1.8 1.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 4.9 -0.0 0.7 -2.2 0.6 -1.1 0.7
Angina 0.6 0.7 2.8 -0.7 -0.2 0.7 1.7 0.0 0.8
Medication for hormone replacement therapy 0.8 0.9 4.4 0.0 -0.4 2.1 0.4 -0.6 0.2
Vitamin and mineral supplements 0.7 0.9 2.1 -0.5 -0.6 1.2 1.1 1.5 0.3
Supplements: Zinc 0.8 0.9 2.1 -0.0 1.1 -1.1 -0.5 -0.7 -1.5
Medication: Co-codamol 0.8 0.9 2.0 -0.6 -0.8 -0.8 1.4 -0.4 1.3
Medication: Metformin 7.2 10.2 17.0 -4.1 -3.3 -3.2 3.4 -3.1 -1.1
Diabetes (father) 1.3 1.6 8.3 0.1 0.1 -2.9 -0.8 0.2 -0.7
Diabetes (mother) 3.4 4.4 10.3 -3.2 -1.7 -0.9 3.2 -1.3 -0.6
Severe depression (siblings) 1.2 1.3 3.9 1.5 1.1 0.3 -0.6 0.3 2.0
Pack years adult smoking proportion 0.6 0.9 2.6 -0.8 -0.7 1.6 0.4 -0.7 -0.9
Impedance of leg (right) 9.0 44.7 182.2 -4.6 -3.9 13.5 6.6 -0.5 2.3
Leg fat-free mass (left) 10.0 54.0 182.2 5.4 5.0 -13.5 -8.6 -0.1 -3.7
Trunk fat percentage 3.5 14.5 83.2 0.1 1.5 -9.1 -0.4 -0.4 -1.1
Hand grip strength (right) 1.7 4.5 13.9 2.6 1.9 1.4 -3.7 -0.5 -0.6
Townsend deprivation index at recruitment 0.4 0.5 1.4 -0.1 -0.3 1.2 1.1 0.7 0.1
Current tobacco smoking 0.5 0.9 2.1 -1.2 -1.0 0.1 1.4 -0.8 0.1
Average weekly fortified wine intake 1.1 1.3 2.5 1.6 1.6 -1.3 -0.7 0.6 0.6
Maternal smoking around birth 2.0 2.9 10.8 -0.6 -0.3 3.3 1.8 0.1 1.7
Fed-up feelings 0.5 1.0 2.7 -0.1 -0.4 -1.7 1.2 -0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 -0.7 -1.1 -0.9 0.9 -1.3 -0.0
Relative age voice broke 0.5 0.8 3.5 0.5 1.0 1.9 0.2 0.1 0.1
Taking other prescription medications 2.4 3.8 8.4 -0.8 -0.2 -1.9 2.7 1.5 2.9
Age when periods started (menarche) 2.6 6.4 34.7 -0.6 -1.2 5.9 1.0 0.7 0.7
Bilateral oophorectomy (both ovaries removed) 1.2 1.3 2.7 -1.4 -1.6 -0.0 0.6 -1.3 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 1.4 -1.2 -0.8 -1.1 0.0 -0.6 -1.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.1 1.5 1.8 0.7 -1.7 0.7 -0.4
Qualifications: CSEs or equivalent 0.8 1.1 3.6 1.3 -0.5 -0.8 -0.4 -0.2 1.9
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.4 0.3 -0.0 0.2 -0.2 0.4
High blood pressure 1.8 5.2 15.8 -2.3 -0.8 -2.6 4.0 0.9 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.2 0.7 1.3 -0.4 0.1 0.1 1.5
Multivitamins +/- minerals 0.7 0.9 1.8 0.5 -0.1 -1.3 -1.3 -1.1 -0.6
Stomach or abdominal pain in last month 0.2 0.3 1.3 0.4 -1.1 -0.3 0.0 0.4 -0.2
Supplements: Glucosamine 2.1 2.7 10.7 -0.1 1.1 -0.8 -1.7 0.9 -3.3
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 7.7 -0.6 0.4 0.3 -0.3 2.8 -0.7
Medication: Atenolol 1.3 1.6 2.7 1.6 1.4 -1.4 -1.1 0.0 1.4
Medication: Levothyroxine sodium 0.4 0.7 3.0 0.1 -0.0 -1.7 0.1 0.1 1.0
Sitting height 3.7 26.5 83.4 5.7 4.4 -2.1 -9.1 -1.4 -4.2
Chronic bronchitis/emphysema (father) 2.3 2.7 5.4 2.3 2.0 -1.7 -1.2 0.4 1.5
High blood pressure (mother) 0.6 0.9 2.2 -0.3 -0.8 -0.9 1.3 -1.5 0.1
Body mass index (BMI) 7.9 34.7 204.3 0.5 1.8 -14.3 -0.5 0.1 -0.6
Impedance of leg (left) 9.0 44.3 185.0 -4.3 -3.5 13.6 6.6 -0.4 2.6
Leg predicted mass (left) 10.0 54.0 182.2 5.4 5.1 -13.5 -8.5 -0.1 -3.8
Trunk fat mass 5.7 25.2 134.6 1.3 2.4 -11.6 -2.3 -0.6 -1.8
Waist circumference 7.7 29.1 163.8 1.2 2.4 -12.8 -1.4 0.2 -1.1
Number of incorrect matches in round 0.1 0.2 0.8 0.3 -0.5 0.3 0.3 -0.4 0.9
Past tobacco smoking 3.1 5.9 13.2 -2.7 -3.0 3.6 1.4 0.7 -1.7
Alcohol usually taken with meals 1.8 3.0 7.6 1.4 0.9 -2.0 -2.8 -0.3 -1.8
Nervous feelings 1.5 2.9 10.3 -1.4 -0.4 3.2 1.9 -0.8 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.6 -0.2 0.7 0.7 -0.2 0.3
Hearing difficulty/problems with background noise 3.4 5.5 12.0 3.2 3.5 0.5 -3.3 0.5 -0.0
Hair/balding pattern: Pattern 2 3.0 3.8 9.5 -2.0 -3.1 1.8 0.9 -0.9 -2.1
Had menopause 0.7 0.9 2.3 -1.1 -0.8 0.6 1.5 1.0 -0.1
Had other major operations 0.2 0.2 0.8 -0.1 -0.1 0.5 -0.4 0.9 -0.3
Forced vital capacity (FVC) 1.2 4.6 14.4 2.2 1.9 1.3 -3.8 -0.9 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.3 -0.9 -0.6 -2.1 0.0 -1.7 -1.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.0 0.8 1.3 -0.3 -1.4 -1.4 -0.1
Qualifications: None of the above 3.8 8.3 27.1 -3.3 -1.6 2.0 5.2 0.6 2.2
Financial difficulties in last 2 years 2.3 3.1 9.1 0.4 -1.2 -1.7 0.9 -2.0 3.0
Mouth/teeth dental problems 0.3 0.4 1.1 0.3 -0.1 1.0 -1.1 0.3 -0.6
Heart attack 0.1 0.2 0.3 0.4 -0.2 -0.3 0.4 -0.5 0.5
Allergy 0.3 0.8 2.4 -0.6 -0.7 1.6 0.4 0.4 -1.0
Pain all over the body in last month 2.6 2.8 10.0 0.8 1.3 0.4 1.2 1.7 3.2
Diabetes (self-reported) 7.9 12.3 21.3 -4.6 -3.3 -3.6 4.3 -2.7 -1.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.5 0.6 0.1 1.2 0.2 -0.6 0.9
Medication: Ramipril 0.8 1.0 4.1 0.3 -0.8 -2.0 0.0 -0.5 0.9
Medication: Simvastatin 1.6 2.3 9.1 -1.0 0.3 -3.0 1.6 -0.4 1.0
Fluid intelligence score 5.0 10.5 34.4 4.0 2.0 -2.5 -5.9 -0.2 -1.5
Illnesses of siblings 2.8 4.1 14.6 1.6 0.1 1.9 -3.8 -0.8 -1.7
Neuroticism score 0.1 0.2 0.4 -0.1 0.5 -0.0 0.5 -0.4 0.6
Weight 8.7 44.1 201.6 3.4 4.0 -14.2 -5.3 -0.4 -2.7
Impedance of arm (right) 3.7 17.8 104.0 -0.9 -0.8 10.2 0.9 -0.4 -0.6
Arm fat percentage (right) 5.3 21.5 125.4 0.3 1.5 -11.2 -0.4 -0.2 -1.0
Trunk fat-free mass 7.0 41.0 118.8 5.2 4.4 -10.9 -8.2 -0.3 -3.5
Hip circumference 9.5 41.9 174.2 4.1 4.0 -13.2 -6.1 -0.5 -2.7
Time employed in main current job 0.9 1.1 2.8 1.4 1.2 -0.2 0.1 -0.3 1.7
Alcohol intake versus 10 years previously 2.0 3.0 6.5 -1.4 -1.7 -0.2 2.5 -1.3 2.2
Father’s age at death 0.6 0.8 2.8 0.7 0.5 0.4 -1.7 0.4 -1.1
Worrier / anxious feelings 0.5 1.0 2.3 -0.6 0.8 0.8 1.5 1.2 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 4.3 -1.6 -0.8 -0.4 2.1 -0.1 1.5
Falls in the last year 0.6 0.8 2.2 -0.9 -0.6 -1.5 1.0 0.5 -0.2
Hair/balding pattern: Pattern 3 0.9 1.3 3.2 -1.8 -1.4 0.2 1.2 -0.8 0.6
Number of live births 1.1 1.6 4.4 2.1 0.6 0.5 -1.2 0.7 1.6
Forced expiratory volume in 1-second (FEV1) 0.8 2.9 7.3 1.8 2.1 1.1 -2.7 -0.8 -0.8
Pulse rate 6.1 10.4 27.1 -4.4 -2.7 2.1 5.2 -2.0 -0.3
Happiness 0.6 0.8 3.3 -0.2 -0.1 -0.5 -0.8 -0.5 -1.8
Noisy workplace 1.4 1.8 5.4 -0.6 -0.3 -0.2 2.3 -0.3 2.1
Qualifications: A levels/AS levels or equivalent 2.6 5.9 16.1 2.7 3.0 -0.9 -4.0 0.8 -1.2
Serious illness, injury or assault of a close relative in last 2 years 3.4 3.9 8.1 2.8 1.0 -2.4 -2.8 -0.5 0.7
Mouth/teeth dental problems: Dentures 0.7 1.3 2.0 -1.1 -1.0 -1.4 1.4 0.1 -1.2
Asthma 0.6 1.1 3.5 0.3 0.2 -1.9 0.0 -0.4 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.2 0.8 -0.5 1.5 -0.7 1.1 1.5
Medication: Cholesterol lowering 3.0 4.5 12.7 1.7 2.0 -3.6 -0.6 -0.4 2.7
Depression (self-reported) 0.5 0.6 1.4 -0.1 0.3 -0.6 0.9 0.8 1.2
Medication: Lansoprazole 2.0 2.3 7.0 -2.0 -1.1 0.1 2.7 0.9 0.8
Prospective memory result 1.7 2.1 4.1 -2.0 -0.4 1.8 2.0 -0.8 -0.6
Lung cancer (father) 1.2 1.3 2.7 1.5 1.6 0.2 -0.9 1.2 0.8
Illnesses of mother 0.7 0.9 4.0 0.8 0.4 0.7 -2.0 0.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 7.1 1.5 1.8 0.9 -2.7 -1.0 -1.3
Pulse wave Arterial Stiffness index 1.5 1.7 3.6 -1.6 -1.1 -0.4 1.9 -1.6 0.5
Impedance of arm (left) 3.6 16.8 98.0 -0.8 -0.8 9.9 0.5 -0.8 -0.8
Arm fat mass (right) 7.4 31.4 169.0 1.8 2.7 -13.0 -2.5 -0.0 -1.5
Trunk predicted mass 7.0 40.9 118.8 5.2 4.4 -10.9 -8.3 -0.4 -3.5
Standing height 3.5 35.7 116.6 6.8 5.5 -1.3 -10.8 -0.7 -4.3
Length of working week for main job 1.3 1.5 7.7 -0.3 -0.6 0.3 0.7 -2.8 -0.2
Exposure to tobacco smoke at home 2.1 2.3 4.8 -1.4 -1.9 -1.0 2.2 0.2 1.6
Breastfed as a baby 1.1 1.4 3.1 1.1 1.8 -0.1 -1.7 -0.8 -0.7
Tense / ‘highly strung’ 0.3 0.6 1.4 -0.1 -0.3 1.2 0.8 -1.1 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 6.1 1.2 1.3 -2.5 -0.3 0.5 0.7
Hair/balding pattern: Pattern 4 1.0 2.4 6.4 -1.3 -1.5 0.3 2.5 -2.0 0.5
Birth weight of first child 1.5 2.8 10.6 2.3 0.7 0.2 -3.3 -0.1 -0.5
Peak expiratory flow (PEF) 0.8 1.9 5.0 1.0 1.4 -0.3 -2.2 -1.4 -1.1
Pulse wave reflection index 0.7 0.8 3.0 0.8 0.0 -0.7 -0.8 1.7 0.5
Ever highly irritable/argumentative for 2 days 4.1 4.9 9.6 2.5 3.1 -2.2 -2.0 2.0 0.5
Loud music exposure frequency 0.7 0.7 3.0 -0.2 -0.5 -0.1 -1.0 -0.4 -1.7
Qualifications: O levels/GCSEs or equivalent 2.6 4.2 9.6 2.4 2.2 -1.8 -3.1 1.2 -0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.5 0.4 0.7 -0.7 -1.2 -0.4 -0.3
Blood clot in the leg (DVT) 0.6 0.7 1.3 -0.3 -1.2 -1.1 -0.6 -0.9 -0.8
Medication: Paracetamol 1.1 1.9 2.8 -0.4 -1.6 1.6 0.8 1.6 1.7
Headache pain in last month 1.5 2.7 5.8 -2.0 -1.7 1.8 2.4 -0.7 0.5
Medication for cholesterol, blood pressure or diabetes 4.2 7.0 19.4 -2.1 -2.7 4.4 0.9 -1.2 -2.9
Glaucoma (self-reported) 0.7 0.9 2.1 -0.4 0.6 -0.9 1.4 0.8 1.2
Gout (self-reported) 0.3 0.4 0.6 0.8 0.7 -0.6 -0.8 -0.0 0.1
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.2 0.3 0.7 -1.8 0.2 -0.5 1.4
Medication: Amlodipine 0.9 1.3 3.5 0.7 0.6 -1.8 0.1 -0.1 1.9
Medication: Ventolin 100micrograms inhaler 1.0 1.3 5.6 0.7 1.1 -0.5 0.3 -0.3 2.4
Birth weight 3.0 6.5 10.2 2.8 2.3 -2.7 -3.2 2.9 0.4
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.2 -0.8 -1.1 1.5 1.4 0.7 0.1
High blood pressure (siblings) 1.7 2.5 7.8 -1.0 -0.2 -1.6 2.8 1.0 1.6
Forced vital capacity (FVC), Best measure 1.3 4.8 15.3 2.0 1.9 1.1 -3.9 -0.9 -1.8
Body fat percentage 4.1 16.7 97.4 -0.8 0.9 -9.9 0.9 -0.6 -0.7
Leg fat percentage (right) 5.2 19.2 94.4 -2.6 -0.6 -9.7 3.6 -0.6 0.4
Arm fat-free mass (right) 6.6 34.7 127.7 4.0 3.6 -11.3 -6.5 -0.2 -3.1
Exposure to tobacco smoke outside home 1.4 1.9 4.6 0.1 0.0 -2.0 1.4 -1.0 2.1
Comparative body size at age 10 10.9 30.6 182.2 0.3 0.9 -13.5 -0.5 -0.1 -0.2
Number of full brothers 0.4 0.5 1.7 0.2 -0.6 -0.2 0.7 0.3 1.3
Worry too long after embarrassment 0.8 1.4 3.0 1.4 1.2 -0.7 -1.7 1.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.0 0.5 -0.3 0.6 -0.2 0.1
Wheeze or whistling in the chest in last year 2.4 4.3 12.2 1.2 2.2 -2.6 0.6 0.8 3.5
Number of children fathered 0.5 0.5 1.1 0.6 0.7 -1.0 -0.4 0.5 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.7 -0.1 -0.5 -1.6 1.0 -0.8 0.8
Age at first live birth 1.6 3.0 6.5 1.9 1.9 -1.2 -2.6 -1.2 1.2
Pulse wave peak to peak time 2.4 2.9 6.7 2.0 1.6 0.5 -2.6 1.8 -0.8
Health satisfaction 2.9 3.7 9.3 -3.1 -2.3 -0.4 2.8 -0.4 -0.3
Shortness of breath walking on level ground 0.5 0.6 1.9 0.0 -0.4 -1.1 0.4 -0.4 1.4
Qualifications: College or University degree 2.8 8.9 33.2 3.1 2.0 -1.4 -5.8 0.7 -2.0
Eye problems/disorders: None of the above 1.0 1.2 2.6 1.2 -1.2 1.1 -1.6 -0.4 -0.2
Mouth/teeth dental problems: Loose teeth 1.2 1.4 3.4 -1.4 -1.6 -0.0 1.9 0.0 0.8
Emphysema/chronic bronchitis 0.7 0.8 2.3 0.0 0.2 -1.2 0.5 0.9 1.5
Medication for pain relief, constipation, heartburn 1.2 2.2 2.9 0.7 1.3 -1.6 -1.7 -1.6 -1.7
Neck or shoulder pain in last month 0.3 0.4 0.7 -0.8 -0.6 0.9 0.6 -0.3 -0.6
Medication: Blood pressure 2.4 4.3 9.3 1.2 2.1 -3.0 -0.1 2.4 2.3
Angina (self-reported) 0.8 1.1 4.0 -1.0 -0.4 0.9 2.0 -0.3 0.7
Migraine (self-reported) 1.0 1.3 3.5 -1.3 -1.3 0.5 1.9 -0.1 0.7
Medication: Ibuprofen 0.4 0.5 1.1 0.2 -1.1 1.0 -0.6 0.5 0.5
Medication: Allopurinol 2.0 2.6 5.2 2.3 0.9 -1.5 -2.0 1.0 1.4
Medication: Omeprazole 3.3 3.9 9.8 0.3 -0.1 1.2 1.7 3.1 3.1
Medication: Seretide 50 evohaler 0.9 1.1 2.1 -1.5 -1.1 1.3 1.1 0.1 -0.2
Mean time to correctly identify matches 0.2 0.4 1.7 0.7 1.3 0.1 -0.0 0.1 0.1
Heart disease (mother) 0.5 0.6 2.2 0.2 0.8 -0.5 0.3 1.5 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.1 0.4 -0.1 -0.8 -0.7 0.2 -1.1
Whole body fat mass 6.3 27.1 151.3 0.9 2.1 -12.3 -1.8 -0.6 -1.5
Leg fat mass (right) 6.9 27.5 161.3 0.1 1.8 -12.7 -0.3 -0.3 -0.6
Arm predicted mass (right) 6.8 35.7 139.2 3.9 3.6 -11.8 -6.2 -0.2 -2.8
Pulse rate, automated reading 7.1 23.3 55.7 -7.3 -4.5 2.3 7.5 -1.2 -1.8
Alcohol intake frequency. 0.8 1.9 5.5 -1.2 -0.1 -2.4 1.7 0.4 1.0
Comparative height size at age 10 3.4 19.2 52.1 5.0 4.2 -3.6 -7.2 -1.1 -2.6
Number of full sisters 0.6 0.7 2.1 0.8 0.6 -0.9 0.5 -0.1 1.4
Suffer from ‘nerves’ 0.5 0.8 1.7 0.0 1.0 1.3 0.5 0.0 1.3
Overall health rating 3.8 8.1 23.2 -4.2 -2.7 -0.5 4.8 -0.3 0.4
Chest pain or discomfort 0.8 1.1 2.7 0.6 0.4 -1.1 0.4 1.5 1.7
Had major operations 2.4 2.8 5.5 1.6 1.5 -2.3 -1.7 1.6 1.2
Age at last live birth 1.9 2.8 4.2 2.0 2.0 0.3 -1.9 -1.6 1.5
Family relationship satisfaction 0.4 0.5 1.3 -0.7 0.0 0.1 1.0 -1.1 -0.5
Leg pain on walking 0.7 0.8 2.9 -0.8 -1.7 -0.4 1.0 -0.3 0.5
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 8.0 -1.7 -2.8 2.0 1.8 -1.2 -1.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 -0.0 0.6 -0.6 0.0 -0.2 -0.0
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.3 -1.2 -0.5 1.0 -0.1 1.1 -1.1
Medication: Aspirin 1.0 1.3 3.1 -1.3 -0.5 -0.7 1.7 -1.4 -0.1
Supplements: Vitamin C 0.6 0.7 2.4 -0.5 -0.5 0.3 -0.3 -1.5 -1.1
Knee pain experienced in last month 0.3 0.4 1.9 -0.1 -0.3 -0.6 -0.4 0.2 -1.4
Hypertension (Self-reported) 2.0 5.7 18.0 -2.2 -1.0 -2.5 4.2 0.6 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 4.8 -1.4 -1.3 -0.1 2.2 1.9 0.8
Illnesses of father: Heart disease 0.2 0.3 1.1 0.3 0.6 -0.1 -0.1 0.5 1.1
Illnesses of siblings: Diabetes 2.1 2.6 6.3 0.3 2.4 -2.5 1.2 0.6 1.1
Smoking status: Previous 2.7 4.1 11.8 2.0 2.1 -3.4 -0.4 -0.2 2.0
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.4 9.6 1.8 0.9 -1.1 -3.1 -1.6 -1.8
Whole body fat-free mass 8.4 48.8 156.2 5.4 4.8 -12.5 -8.5 -0.2 -3.7
Leg fat-free mass (right) 10.2 55.7 176.9 5.8 5.3 -13.3 -9.0 -0.0 -3.8
Arm fat percentage (left) 5.6 22.7 132.2 0.2 1.5 -11.5 -0.5 -0.5 -1.2
Average weekly red wine intake 2.6 3.8 10.9 -0.2 -0.2 -3.3 -1.2 -0.3 -3.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 2.0 -0.3 -0.8 -1.4 -0.1 -0.2 0.1
Mood swings 0.3 0.5 1.5 -0.3 -1.2 -0.1 0.9 0.4 0.6
Loneliness, isolation 1.0 1.3 3.3 -1.4 -1.3 -0.2 0.6 -1.8 -0.8
Long-standing illness, disability or infirmity 1.2 1.8 6.1 -1.8 -0.2 -1.0 2.5 0.3 0.4
Ever had bowel cancer screening 1.8 2.1 9.7 0.7 1.2 -0.1 -0.8 3.1 0.4
Diabetes diagnosed by doctor 8.9 14.7 24.1 -4.9 -3.8 -4.2 4.5 -3.0 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.8 0.5 0.6 0.7 0.1 0.7 1.7
Friendships satisfaction 0.7 0.9 1.7 1.3 1.0 -0.5 -1.3 0.7 0.7
Qualifications: nursing, teaching 3.9 6.2 10.8 2.6 3.2 -2.4 -3.3 -0.5 -1.9
Commuting to job workplace: Walk 0.5 0.5 1.2 -0.1 0.1 -0.8 -0.8 1.1 -0.7
Eye problems/disorders: Cataract 0.8 0.9 3.0 -0.4 1.7 -0.7 1.2 0.6 0.4
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 5.1 2.2 1.4 0.7 -1.0 -0.0 2.3
Medication for cholesterol 2.7 4.2 16.3 2.4 1.4 0.7 -4.0 0.3 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 4.3 -0.5 -0.4 -0.7 0.4 -2.1 -1.9
Back pain experienced in last month 2.1 3.1 12.5 -2.1 -3.5 -0.2 1.1 -0.5 -0.4
Mineral and other dietary supplements 1.5 2.0 6.5 -0.3 -1.1 -0.6 1.6 -1.0 2.5
Breast cancer (self-reported) 1.1 1.3 3.5 1.8 0.9 0.1 -1.9 0.6 0.0
Asthma (self-reported) 0.6 1.1 3.8 0.2 0.4 -1.9 0.2 -0.5 1.6
Osteoporosis (self-reported) 2.4 2.9 6.0 -1.8 -1.6 2.5 1.4 0.4 -1.8
Osteoarthritis (self-reported) 2.1 2.8 7.5 -1.7 -0.6 -1.9 2.7 1.4 0.5
Medication: Aspirin 1.2 1.6 3.5 -1.4 -0.6 -1.1 1.9 -1.6 -0.1
Medication: Gliclazide 1.6 1.8 5.2 -1.6 0.2 -2.3 1.3 -1.0 0.3
Illnesses of father: None of the above (group 1) 2.0 2.4 6.9 -1.5 -0.1 2.6 1.0 -1.0 -1.9
Smoking status: Current 0.2 0.3 0.6 -0.7 -0.6 -0.2 0.8 -0.6 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -1.0 -1.2 1.3 0.9 -0.1 0.1
Whole body water mass 8.5 49.3 156.2 5.4 4.8 -12.5 -8.6 -0.1 -3.7
Leg predicted mass (right) 10.1 55.1 176.9 5.8 5.2 -13.3 -8.9 -0.0 -3.8
Arm fat mass (left) 7.9 33.5 179.6 1.8 2.7 -13.4 -2.8 -0.3 -1.8
Number of self-reported non-cancer illnesses 1.8 3.2 8.0 -1.1 -0.1 -1.9 2.8 0.8 2.4
Average weekly champagne plus white wine intake 2.5 3.5 12.6 2.0 1.5 -1.2 -3.6 0.3 -0.7
Miserableness 0.7 1.2 2.2 1.5 1.0 -0.9 -1.5 -0.5 0.9
Guilty feelings 0.5 0.8 3.1 -0.6 0.1 -0.6 0.8 0.6 1.8
Wears glasses or contact lenses 0.8 0.9 2.7 -1.6 -0.0 0.2 1.5 0.4 -0.5
Ever taken oral contraceptive pill 1.6 1.8 3.7 1.7 1.9 -0.5 -1.0 0.4 1.7
Hearing aid user 1.4 1.6 4.7 0.6 1.5 2.2 -0.8 0.7 -1.0
Mother’s age at death 0.6 0.7 1.5 1.2 0.9 -0.1 -1.1 0.9 -0.2
Financial situation satisfaction 1.6 1.9 5.2 -1.4 -1.7 0.0 1.3 -2.3 -0.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.0 -0.6 -0.8 1.7 1.0 -1.7 0.5
Commuting to job workplace: Public transport 0.8 1.0 3.4 -0.1 -0.3 -1.3 0.2 -1.9 -0.6
Eye problems/disorders: Glaucoma 0.6 0.7 2.2 -0.6 0.4 -0.9 0.8 1.5 -0.2
Medication: Blood pressure 1.6 3.1 8.3 -2.1 -0.9 -2.3 2.9 -0.5 -0.0
Pain type(s) experienced in last month: Hip pain 2.3 3.0 5.6 -1.7 -2.4 -2.2 1.5 -1.3 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.3 0.7 1.5 0.3 -0.9 1.4 -1.2
High cholesterol (Self-reported) 1.0 1.7 5.8 -0.1 -0.7 -2.4 1.2 -0.4 1.5
Medication: Bendroflumethiazide 1.3 2.0 8.4 0.4 1.2 -2.9 0.7 1.3 0.3
Medication: Paracetamol 0.5 0.9 4.2 -0.4 -2.0 0.7 0.3 0.3 0.4
Medication: Lisinopril 0.8 1.0 2.2 -0.2 0.8 -1.5 1.0 -0.4 1.4
Medication: Atorvastatin 1.5 1.9 5.4 1.1 0.0 -2.1 0.7 -0.3 2.3
Illnesses of father: High blood pressure 1.1 1.3 3.4 0.5 0.1 -1.9 0.4 1.0 1.8
Alcohol drinker status: Never 0.5 0.6 3.3 -0.4 -0.1 -1.8 0.1 -0.1 -0.1
Ever smoked 1.2 2.1 4.9 1.2 2.2 -1.8 -1.3 -1.2 -0.1
Basal metabolic rate 8.8 49.7 174.2 5.1 4.8 -13.2 -8.0 -0.3 -3.5
Leg fat percentage (left) 5.4 19.8 99.1 -2.4 -0.4 -10.0 3.6 -0.7 0.6
Arm fat-free mass (left) 7.2 37.2 141.6 4.1 3.7 -11.9 -6.4 -0.3 -3.1
Number of operations (self-reported) 0.7 1.1 2.8 1.0 0.1 -1.3 -1.7 0.9 0.1
Average weekly beer plus cider intake 1.3 1.8 8.6 -0.0 0.6 2.9 1.3 0.4 0.6
Irritability 1.8 3.1 6.1 2.0 2.5 -1.8 -2.1 0.6 0.2
Risk taking 1.0 1.5 3.2 1.0 0.2 1.2 -0.5 -1.8 1.7
Ever had prostate specific antigen (PSA) test 1.7 1.9 6.0 0.9 -0.3 -0.7 -2.4 -1.5 -1.4
Fractured/broken bones in last 5 years 0.9 1.2 3.5 0.8 1.9 -0.4 -0.9 1.2 -0.7
Age started oral contraceptive pill 0.3 0.4 1.3 -0.2 -0.6 -0.0 -0.2 -0.9 -1.1
Diastolic blood pressure, automated reading 0.4 1.2 3.2 0.2 0.6 -0.1 1.4 1.2 1.8
Ever depressed for a whole week 1.2 1.5 2.6 1.2 0.5 -1.6 -1.6 -1.1 0.9
Unable to work because of sickness or disability 1.0 1.3 2.8 -1.0 -1.7 0.6 1.2 -1.0 1.0
Commuting to job workplace: Cycle 3.2 3.8 8.0 2.5 2.3 -0.7 -2.8 1.8 0.2
Myopia 0.9 1.3 5.2 1.0 1.0 0.1 -2.3 0.0 -0.7
Vascular/heart problems diagnosed by doctor 1.7 4.8 14.9 2.2 1.0 2.2 -3.9 -1.1 -1.4
Cholesterol lowering medication 2.2 3.2 8.3 -2.1 -1.9 -1.4 2.9 0.9 -0.4
Medication: Omeprazole (e.g. Zanprol) 2.5 3.0 8.0 0.2 -0.3 1.0 1.2 2.8 2.8
Pain experienced in last month 1.5 2.6 5.6 1.9 2.4 -1.0 -2.3 -0.2 -0.6
Supplements: Calcium 0.2 0.2 0.7 -0.2 0.2 0.5 0.0 -0.6 0.9
Basal cell carcinoma (self-reported) 0.7 0.9 4.1 0.5 0.1 -0.2 -2.0 0.2 -0.9
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.4 0.6 0.1 -0.5 0.2 -0.4 0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.0 -0.6 -1.4 -0.8 -0.4 -1.3 -0.7
Heart disease (siblings) 1.9 2.3 5.3 -2.3 -1.7 -0.6 2.2 0.3 -0.9
Alcohol drinker status: Previous 0.7 0.8 2.3 -0.2 1.3 1.5 0.1 1.0 0.0
Pack years of smoking 0.5 0.8 2.5 -0.8 -0.6 1.6 0.5 -0.7 -0.8
Impedance of whole body 6.7 35.0 179.6 -2.8 -2.4 13.4 3.9 -0.5 0.9
Leg fat mass (left) 6.9 27.6 161.3 0.2 1.9 -12.7 -0.3 -0.3 -0.5
Arm predicted mass (left) 7.3 37.9 144.0 4.2 4.1 -12.0 -6.4 -0.2 -2.8