Hub : Genes

AP001266.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.145	0.0650	5.6e-03	-0.002	NA	-0.003	NA	-0.003	0.3800	NA	4.1e-01	NA	4.2e-01
2	GTEx	Artery Tibial	0.113	0.0385	2.6e-05	0.022	NA	0.086	NA	0.077	0.0074	NA	2.8e-07	NA	1.2e-06
3	GTEx	Esophagus Mucosa	0.072	0.0300	8.3e-04	0.006	NA	0.011	NA	0.004	0.1200	NA	5.5e-02	NA	1.7e-01
4	GTEx	Esophagus Muscularis	0.111	0.0460	1.4e-03	0.005	NA	0.030	NA	0.027	0.1500	NA	6.1e-03	NA	9.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.6	4.0	1.0	1.1	0.5	2.0
Bipolar Disorder or Schizophrenia	2.3	5.7	9.8	1.5	2.4	2.3	3.1
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.9	0.7	-0.0	0.3
Depression (Nagel 2018)	0.3	0.4	1.0	1.0	0.1	0.6	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.9	-0.2	-0.9	-0.8	-0.9
Neuroticism (Nagel 2018)	0.5	1.1	3.0	-0.5	1.1	0.2	1.7
Schizophrenia (2018)	2.2	4.5	6.4	1.1	2.1	2.5	2.4
Schizophrenia vs Biploar Disorder	0.9	1.2	3.1	-0.0	0.1	1.7	-1.3
Worry (Nagel 2018)	0.7	1.5	3.3	-0.2	1.0	1.3	1.8
Alzheimer’s Disease (in mother)	1.7	2.0	2.9	-0.9	-1.7	-1.7	-1.2
Alzheimer’s Disease (in father)	1.3	1.4	1.8	-0.7	-1.3	-1.3	-1.3
Alzheimer’s Disease (including proxy)	0.8	1.2	1.6	-0.6	-1.2	-1.1	-1.2
Crohns Disease (2017)	1.1	2.3	4.7	0.7	-2.2	1.2	-1.6
Irritable Bowel Disease (IBD)	0.5	1.3	2.2	0.9	-1.5	1.5	-0.3
Ulcerative Colitis (UC)	0.3	0.5	1.0	0.5	-0.2	1.0	0.8
Major Depression (MDD)	2.4	3.0	5.6	0.8	2.1	1.1	2.4
Reaction Time	5.1	9.7	11.3	2.2	3.4	3.4	3.3
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.7	1.3	-1.9	-0.5	-1.8
Breast Cancer	4.7	11.4	15.1	-3.1	3.0	-3.5	3.9
Ovarian Cancer	0.8	1.1	1.8	-1.4	-0.6	-1.1	-0.9
Prostate Cancer	2.1	2.9	9.5	1.0	0.7	3.1	0.8
Age at First Birth	0.1	0.1	0.3	0.3	-0.1	0.4	0.6
Bipolar Disorder (2011)	0.8	0.8	2.0	0.1	-0.3	-1.1	1.4
Body Mass Index (BMI) (2010)	1.9	2.7	4.8	1.3	2.1	2.2	0.1
Coronary Artery Disease (CAD)	1.2	1.5	4.0	-0.6	-0.9	-2.0	-0.8
Crohns Disease (2012)	0.4	0.6	1.3	0.3	-1.1	0.9	-0.5
Mean Putamen Volume	2.9	3.3	9.6	1.0	1.4	3.1	0.8
Fasting Glucose	0.4	0.5	1.4	-0.5	1.2	0.5	-0.0
HbA1C	0.1	0.1	0.4	-0.0	0.6	0.3	0.2
HDL Cholesterol	0.8	1.4	3.5	-0.8	-1.1	-1.9	0.4
LDL Cholesterol	2.8	4.5	14.0	1.6	1.0	3.7	0.6
Lupus	0.4	0.6	1.4	-0.7	-0.2	1.2	-0.7
Neuroticism (2016)	0.2	0.3	0.4	-0.6	-0.7	-0.4	-0.2
Primary Biliary Cirrhosis	0.3	0.4	1.4	0.3	0.2	1.2	0.3
Rheumatoid Arthritis	1.1	1.5	3.5	-1.1	-1.9	-0.8	-0.8
Schizophrenia (2014)	1.4	3.2	7.1	0.5	1.8	2.7	1.5
Triglycerides	0.6	0.9	2.0	-1.2	0.6	-0.2	-1.4
Type 2 Diabetes (T2D) (2012)	2.3	2.7	4.6	1.1	2.0	2.1	1.0
Ulcerative Colitis	0.2	0.3	0.8	0.1	-0.9	0.2	0.7
Blood Eosinophil Count	7.5	57.6	114.5	-10.7	1.9	-9.4	4.8
Blood Platelet Count	4.4	51.1	114.5	-6.3	-6.7	-10.7	-2.4
Blood Red Count	0.5	5.0	10.6	2.8	-0.7	3.2	-1.1
Blood White Count	1.5	11.2	26.8	-5.2	1.6	-1.9	3.4
Heel T-Score	1.3	10.4	17.0	-3.4	3.3	-4.1	1.5
BMI	0.6	3.6	7.2	1.7	0.8	2.7	-1.9
Height	3.6	69.3	92.2	-9.6	-8.6	-7.9	-7.0
Waist Hip Ratio (WHR)	1.0	4.5	10.6	-3.3	2.6	-0.4	-0.6
Systolic Blood Pressure	0.4	2.2	6.0	1.1	-1.2	-0.2	-2.5
Smoking Status	0.1	0.2	0.4	-0.3	0.5	0.1	-0.7
Allergy or Eczema	8.1	21.5	32.3	-4.7	4.5	-3.3	5.7
Cardiovascular Disease	0.2	0.8	1.8	-0.9	-0.6	0.2	-1.4
Hypothyroidism (self reported)	2.1	4.9	15.3	-3.9	0.6	-1.9	0.7
Respiratory disease	3.8	8.4	19.1	-1.4	4.4	-0.7	3.5
Type 2 Diabetes (T2D) (2018)	2.6	4.8	13.2	-1.1	3.6	1.8	1.3
Lung FEV1/FVC ratio	0.2	1.1	3.4	0.9	-0.5	0.1	-1.9
Lung FVC	0.1	0.6	1.0	-1.0	0.9	0.6	-0.1
Neuroticism	0.3	0.7	2.1	-0.3	0.9	0.0	1.5
Chronotype (morning person)	0.5	1.2	3.4	-1.9	1.1	-0.6	0.2
Hair Pigment	0.2	5.8	20.4	-0.0	-4.5	-0.6	-1.6
Tanning	0.3	3.4	8.2	1.6	2.9	1.1	1.3
Hand grip strength (left)	1.4	3.7	11.1	-3.3	-1.4	-0.8	-1.0
Number of treatments/medications taken	0.5	0.9	3.1	-0.6	-0.3	-1.8	-0.3
Average weekly spirits intake	0.5	0.6	1.3	1.2	0.0	0.7	-0.6
Sensitivity / hurt feelings	0.7	1.3	2.8	-0.1	-1.7	-1.4	-0.3
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	0.1	-0.3	0.9	-0.2
Hearing difficulty/problems: Yes	0.4	0.7	1.0	-1.0	-1.0	-0.6	0.7
Relative age of first facial hair	2.6	5.3	14.5	3.8	-0.4	2.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.2	-0.4	0.1	0.2	-1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	0.0	-0.4	-1.5	0.2
Ever had hysterectomy (womb removed)	2.2	2.5	5.2	0.8	-1.9	-0.6	-2.3
Systolic blood pressure, automated reading	0.3	0.9	1.7	1.3	-0.5	0.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.4	-0.6	1.6	0.6	0.1
Angina	1.0	1.3	2.0	-1.2	-1.2	-0.5	-1.4
Medication for hormone replacement therapy	0.7	0.7	1.7	1.3	-0.1	-1.1	0.3
Vitamin and mineral supplements	0.6	0.8	1.8	1.0	-0.4	1.4	0.4
Supplements: Zinc	0.8	0.9	2.6	0.9	0.3	1.6	0.2
Medication: Co-codamol	1.2	1.4	3.7	1.3	-0.3	1.9	0.1
Medication: Metformin	2.9	4.1	9.1	-0.2	3.0	2.3	1.4
Diabetes (father)	1.7	2.1	3.9	0.4	1.8	2.0	1.1
Diabetes (mother)	1.1	1.4	3.3	-0.2	1.8	1.2	0.9
Severe depression (siblings)	0.6	0.6	1.1	-1.1	-0.2	-1.0	0.5
Pack years adult smoking proportion	0.3	0.5	1.7	-0.2	-0.3	0.5	-1.3
Impedance of leg (right)	0.9	4.5	10.1	-3.2	0.2	-2.8	0.5
Leg fat-free mass (left)	0.8	4.0	9.6	-0.7	-2.4	-0.1	-3.1
Trunk fat percentage	0.3	1.2	3.1	-1.1	-0.7	-0.0	-1.8
Hand grip strength (right)	0.5	1.4	4.4	-2.1	-0.7	-0.4	-0.6
Townsend deprivation index at recruitment	1.2	1.7	3.6	-0.6	-1.4	-0.9	-1.9
Current tobacco smoking	0.6	1.1	2.6	1.6	0.6	0.7	-0.9
Average weekly fortified wine intake	1.5	1.8	5.1	2.3	0.3	0.2	1.3
Maternal smoking around birth	1.5	2.2	3.4	-1.1	-1.7	-1.8	-1.1
Fed-up feelings	0.4	0.7	1.3	-0.5	-1.1	0.5	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.3	0.7	1.0	1.8	0.8
Relative age voice broke	2.3	3.5	10.6	3.2	-0.2	1.8	-0.2
Taking other prescription medications	0.5	0.7	1.7	-1.3	-0.4	-0.9	0.1
Age when periods started (menarche)	0.9	2.1	5.8	-0.8	-1.4	-2.4	-0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	0.7	-0.1	0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.2	-1.6	0.9	-2.1	0.9
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	7.5	2.7	0.3	1.3	-1.2
Qualifications: CSEs or equivalent	0.7	0.9	1.7	-1.0	1.3	0.9	0.2
Serious illness, injury or assault to yourself	0.8	1.0	1.3	0.9	0.8	1.1	-1.2
High blood pressure	0.8	2.2	4.8	-0.4	-1.8	-0.6	-2.2
Hayfever, allergic rhinitis or eczema	6.8	14.9	18.5	-4.3	3.8	-2.9	4.3
Multivitamins +/- minerals	1.0	1.3	3.3	-1.8	0.3	-1.3	-0.3
Stomach or abdominal pain in last month	0.5	0.6	2.1	-0.2	0.3	0.3	-1.5
Supplements: Glucosamine	0.5	0.6	1.1	-1.0	0.2	-0.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.9	0.3	-0.9	-0.1	0.2
Medication: Atenolol	4.8	6.0	9.3	-2.2	-3.0	-2.5	-1.9
Medication: Levothyroxine sodium	1.5	2.6	9.2	-3.0	0.3	-1.1	-0.2
Sitting height	0.3	2.2	3.3	-1.8	-1.5	-0.0	-1.8
Chronic bronchitis/emphysema (father)	1.1	1.3	2.0	0.1	1.4	1.1	1.4
High blood pressure (mother)	0.3	0.4	0.8	-0.5	0.8	-0.0	0.9
Body mass index (BMI)	0.7	3.1	7.3	1.5	0.8	2.7	-1.4
Impedance of leg (left)	0.9	4.6	9.3	-3.0	-0.1	-3.0	0.5
Leg predicted mass (left)	0.8	4.0	9.5	-0.8	-2.5	-0.2	-3.1
Trunk fat mass	0.6	2.6	7.1	-1.1	-1.4	0.1	-2.7
Waist circumference	0.3	1.0	3.3	-0.6	0.0	0.6	-1.8
Number of incorrect matches in round	0.9	1.5	2.9	0.0	-1.6	-1.7	-0.8
Past tobacco smoking	0.2	0.4	0.7	0.1	-0.6	-0.9	-0.6
Alcohol usually taken with meals	0.5	0.7	1.6	1.3	0.0	-1.1	0.4
Nervous feelings	0.2	0.4	0.7	-0.8	0.5	-0.2	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.3	0.4	1.0	-0.1
Hearing difficulty/problems with background noise	0.8	1.3	3.6	-1.3	-0.1	-0.3	1.9
Hair/balding pattern: Pattern 2	1.0	1.3	3.0	0.7	-1.7	0.1	-1.4
Had menopause	0.8	1.0	1.7	-0.9	0.2	-1.3	1.3
Had other major operations	1.2	1.5	4.0	-0.2	-0.9	-1.0	-2.0
Forced vital capacity (FVC)	0.7	2.6	5.3	-2.3	-1.2	-1.2	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	4.8	-2.0	1.0	-2.2	1.3
Ever unenthusiastic/disinterested for a whole week	1.8	2.3	3.8	0.4	1.9	1.8	1.3
Qualifications: None of the above	0.1	0.2	0.4	0.1	-0.6	0.4	-0.3
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.5	0.3	-0.3	-0.4
Mouth/teeth dental problems	2.8	4.4	9.5	-1.4	-1.9	-3.1	-1.5
Heart attack	0.7	0.8	1.8	0.2	-1.3	0.0	-1.3
Allergy	6.7	15.4	21.7	3.7	-4.7	2.5	-4.5
Pain all over the body in last month	0.5	0.5	1.0	0.3	-1.0	0.6	-0.7
Diabetes (self-reported)	1.7	2.6	7.2	-0.8	2.7	1.4	0.9
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	7.2	-2.7	0.2	-2.2	0.3
Medication: Ramipril	0.5	0.7	1.4	-0.7	-0.9	0.1	-1.2
Medication: Simvastatin	1.6	2.4	4.8	0.4	1.5	2.2	1.5
Fluid intelligence score	0.5	1.0	1.3	1.1	-0.8	-1.1	-0.9
Illnesses of siblings	0.2	0.3	0.6	-0.6	-0.1	0.7	0.4
Neuroticism score	0.1	0.2	0.5	-0.5	0.1	0.2	0.7
Weight	0.7	3.6	10.4	-1.0	-1.7	0.4	-3.2
Impedance of arm (right)	1.6	7.3	14.8	-3.2	-0.4	-3.9	1.9
Arm fat percentage (right)	0.3	1.0	2.7	0.5	0.9	1.6	-0.5
Trunk fat-free mass	0.9	5.2	11.6	-1.3	-2.8	-0.4	-3.4
Hip circumference	1.1	4.7	9.1	-0.7	-3.0	-0.6	-3.0
Time employed in main current job	0.1	0.2	0.3	0.2	0.4	0.6	0.3
Alcohol intake versus 10 years previously	1.1	1.6	2.4	-1.5	0.2	-1.3	-1.5
Father’s age at death	0.7	1.0	3.0	-0.1	-1.7	-0.9	-0.2
Worrier / anxious feelings	0.2	0.5	1.5	-0.6	0.0	-0.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.1	-1.0	-1.3	-0.8	-2.0
Falls in the last year	0.3	0.4	1.2	0.3	-0.7	-1.1	0.1
Hair/balding pattern: Pattern 3	1.3	1.9	2.5	1.5	1.6	1.5	0.8
Number of live births	0.2	0.3	0.9	-0.0	-0.2	-1.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	1.8	-1.1	-1.1	-1.0	-1.3
Pulse rate	0.8	1.4	2.2	-0.7	1.0	-1.5	1.4
Happiness	0.7	0.8	2.3	-1.5	-0.1	-0.9	0.0
Noisy workplace	0.7	0.8	2.1	-0.8	-1.5	-0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	0.1	-0.6	-1.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.1	0.5	-0.2	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	1.6	0.7	-0.1	1.1	-1.3
Asthma	6.2	12.2	31.4	-1.6	5.6	-0.3	3.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	4.2	0.3	-2.0	-1.1	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.4	0.3	-0.0	0.6	0.1
Depression (self-reported)	0.9	1.0	1.7	-1.3	0.6	-0.9	1.1
Medication: Lansoprazole	0.3	0.3	0.7	0.8	-0.0	0.7	-0.3
Prospective memory result	0.2	0.3	0.6	-0.0	0.7	-0.1	0.7
Lung cancer (father)	1.8	2.1	4.1	1.5	-0.7	1.3	-2.0
Illnesses of mother	0.0	0.0	0.1	0.0	0.2	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	-1.0	-0.7	-0.8	-0.9
Pulse wave Arterial Stiffness index	1.7	2.0	3.4	-0.4	-1.8	-1.3	-1.7
Impedance of arm (left)	2.1	9.5	19.6	-3.9	-1.2	-4.4	1.2
Arm fat mass (right)	0.2	1.0	2.4	-0.0	0.3	1.5	-1.2
Trunk predicted mass	1.0	5.5	11.9	-1.4	-2.8	-0.5	-3.5
Standing height	2.6	25.4	31.2	-5.5	-5.6	-4.8	-4.1
Length of working week for main job	0.4	0.5	1.1	0.8	0.1	1.1	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.5	-0.1	-0.0	-0.8
Breastfed as a baby	0.3	0.3	0.8	0.9	-0.0	0.0	0.7
Tense / ‘highly strung’	1.5	2.4	6.2	-1.1	1.4	-0.6	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.8	1.4	0.9	1.1	-0.2
Hair/balding pattern: Pattern 4	1.2	2.8	5.4	-1.0	-1.9	-2.3	-1.0
Birth weight of first child	0.3	0.6	1.1	-1.1	0.9	0.6	0.1
Peak expiratory flow (PEF)	0.3	0.8	1.5	-0.0	-0.9	-1.0	-1.2
Pulse wave reflection index	1.5	1.9	3.6	1.1	-1.9	0.7	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.1	0.7	0.7	1.3
Loud music exposure frequency	1.9	2.1	5.7	-2.4	0.2	-1.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	-0.3	-0.4	-1.3	-0.6
Mouth/teeth dental problems: Bleeding gums	3.3	4.3	8.8	1.3	1.9	3.0	1.7
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.2	0.3	0.2	0.3
Medication: Paracetamol	3.5	5.7	9.3	-2.7	-2.0	-3.1	-1.5
Headache pain in last month	0.6	1.0	2.2	-1.5	-0.1	-1.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	-0.7	1.3	0.4	1.6
Glaucoma (self-reported)	2.9	3.4	8.5	-1.8	0.1	-2.9	1.4
Gout (self-reported)	8.7	11.9	18.8	-4.2	-2.2	-4.3	-2.4
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	15.4	-3.9	0.6	-1.8	0.2
Medication: Amlodipine	3.0	4.3	7.5	-2.1	-0.7	-2.7	-2.1
Medication: Ventolin 100micrograms inhaler	3.1	4.0	10.5	0.6	3.2	-0.4	2.2
Birth weight	1.6	3.4	6.5	1.9	1.8	2.5	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	0.4	-1.1	-0.5	-0.4
High blood pressure (siblings)	0.3	0.4	1.0	1.0	-0.3	-0.1	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.3	4.4	-2.1	-0.4	-0.7	-0.4
Body fat percentage	0.2	0.9	3.0	-0.3	-0.0	0.8	-1.7
Leg fat percentage (right)	0.6	2.1	3.7	0.5	1.1	1.9	-1.9
Arm fat-free mass (right)	1.0	5.3	14.7	-0.7	-2.5	0.2	-3.8
Exposure to tobacco smoke outside home	0.7	0.9	1.2	-1.1	0.8	-0.9	1.1
Comparative body size at age 10	3.8	10.5	21.7	3.8	2.1	4.7	1.3
Number of full brothers	0.2	0.3	1.1	-1.1	-0.0	-0.2	-0.1
Worry too long after embarrassment	0.4	0.7	1.5	0.7	0.0	0.8	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.4	-1.8	-0.9	-1.4	-0.0
Wheeze or whistling in the chest in last year	1.5	2.8	7.6	-0.8	2.8	0.4	1.6
Number of children fathered	0.2	0.2	0.3	-0.4	-0.1	0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.2	-0.4	1.4	1.2	1.8
Age at first live birth	1.4	2.5	6.4	-0.3	-2.5	-1.6	-1.0
Pulse wave peak to peak time	1.2	1.4	2.4	-0.0	1.5	1.0	1.6
Health satisfaction	1.2	1.6	3.4	0.5	1.7	1.8	0.0
Shortness of breath walking on level ground	0.5	0.6	0.8	0.9	0.9	0.8	-0.3
Qualifications: College or University degree	0.4	1.3	2.7	-0.1	-1.6	-1.6	-0.5
Eye problems/disorders: None of the above	2.1	2.5	5.8	1.6	1.1	2.4	0.4
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.7	0.4	2.2	1.7	1.1
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.0	0.6	0.4	0.1
Medication for pain relief, constipation, heartburn	1.3	2.3	5.2	1.2	1.4	2.3	0.8
Neck or shoulder pain in last month	1.0	1.4	2.9	0.7	1.7	1.0	1.2
Medication: Blood pressure	1.8	3.2	4.6	-1.2	-1.9	-2.1	-1.7
Angina (self-reported)	0.9	1.2	2.4	-1.1	-1.0	-0.3	-1.6
Migraine (self-reported)	1.0	1.2	2.5	0.3	1.4	0.6	1.6
Medication: Ibuprofen	1.5	1.7	4.0	1.2	-2.0	-1.0	-0.8
Medication: Allopurinol	8.0	10.6	17.0	-4.0	-2.0	-4.1	-2.4
Medication: Omeprazole	0.5	0.6	1.7	0.2	-0.2	0.8	-1.3
Medication: Seretide 50 evohaler	1.1	1.2	1.9	-0.9	1.0	-1.4	1.1
Mean time to correctly identify matches	2.9	5.6	8.7	2.0	2.2	3.0	2.3
Heart disease (mother)	1.0	1.2	4.3	-2.1	0.1	-0.8	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.0	-0.4	-0.5	-0.4
Whole body fat mass	0.5	2.2	6.8	-0.4	-1.0	0.9	-2.6
Leg fat mass (right)	0.6	2.5	5.9	0.4	0.1	2.0	-2.4
Arm predicted mass (right)	1.1	5.7	15.8	-0.6	-2.6	0.1	-4.0
Pulse rate, automated reading	1.4	4.5	8.5	-2.4	-1.9	-2.9	-0.6
Alcohol intake frequency.	2.2	5.2	13.9	-0.9	-2.2	-1.0	-3.7
Comparative height size at age 10	3.0	16.2	26.3	-4.0	-5.1	-3.3	-3.5
Number of full sisters	0.5	0.6	2.0	-0.2	-0.1	-1.4	0.5
Suffer from ‘nerves’	1.1	1.7	3.0	0.4	1.0	1.6	1.7
Overall health rating	1.0	2.1	4.4	0.4	1.9	2.1	-0.6
Chest pain or discomfort	0.6	0.8	1.2	-1.1	0.8	-0.5	-1.1
Had major operations	0.9	1.0	2.8	0.1	-1.1	0.4	-1.7
Age at last live birth	0.8	1.1	2.3	0.6	-1.5	-1.0	-0.9
Family relationship satisfaction	3.2	3.9	6.7	-1.5	2.3	1.2	2.6
Leg pain on walking	0.9	1.2	2.4	0.0	1.3	1.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	3.4	4.1	6.6	1.7	2.6	2.2	1.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	0.4	0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.1	-0.2	0.6	0.9
Medication: Aspirin	1.1	1.4	2.9	-1.4	-0.8	-1.7	-0.4
Supplements: Vitamin C	0.1	0.1	0.2	0.1	-0.4	-0.2	0.2
Knee pain experienced in last month	0.7	1.1	3.1	0.5	0.0	1.8	-1.1
Hypertension (Self-reported)	1.3	3.5	5.4	-1.1	-2.2	-1.5	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.3	-0.1	-0.6	1.1	0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.3	0.7	-0.6	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.2	1.1	-0.5	0.4
Smoking status: Previous	0.3	0.5	1.0	-0.0	0.6	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.4	-0.7	-0.6	-1.2	-0.6
Whole body fat-free mass	0.9	5.4	12.7	-1.0	-2.8	-0.3	-3.6
Leg fat-free mass (right)	0.8	4.4	9.4	-0.7	-2.7	-0.3	-3.1
Arm fat percentage (left)	0.2	0.7	1.8	0.2	0.7	1.3	-0.8
Average weekly red wine intake	1.5	2.2	3.0	1.1	1.7	1.6	1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.7	0.5	-0.0	-0.0	1.9
Mood swings	0.1	0.2	0.6	-0.3	0.8	-0.1	0.3
Loneliness, isolation	0.8	1.1	1.9	-1.4	1.3	0.6	0.8
Long-standing illness, disability or infirmity	0.8	1.2	2.6	0.3	0.6	1.6	-1.3
Ever had bowel cancer screening	0.4	0.5	0.7	-0.4	-0.8	0.7	-0.8
Diabetes diagnosed by doctor	2.5	4.2	11.2	-0.9	3.3	1.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.1	0.7	-1.2	-0.2	-1.8
Friendships satisfaction	7.2	9.0	19.6	-2.0	3.4	1.1	4.4
Qualifications: nursing, teaching	1.9	2.9	5.8	-2.1	-1.1	-2.4	-0.2
Commuting to job workplace: Walk	0.4	0.4	0.9	0.5	-0.2	-1.0	0.7
Eye problems/disorders: Cataract	2.2	2.5	5.8	-1.0	-1.2	-2.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	-1.3	0.7	0.5	1.2
Medication for cholesterol	0.1	0.2	0.4	-0.4	0.2	0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.2	1.0	-0.3	0.4
Back pain experienced in last month	1.4	2.1	3.8	-1.0	-1.2	-1.4	-2.0
Mineral and other dietary supplements	2.4	3.2	6.7	2.6	0.1	2.1	-1.3
Breast cancer (self-reported)	3.5	4.2	10.8	0.1	-3.3	-0.6	-2.3
Asthma (self-reported)	5.8	11.6	28.9	-1.5	5.4	-0.6	3.8
Osteoporosis (self-reported)	0.5	0.6	1.2	1.1	-0.9	0.1	-0.5
Osteoarthritis (self-reported)	0.8	1.0	3.1	-1.8	-0.5	-0.9	0.1
Medication: Aspirin	1.6	2.1	4.7	-1.5	-1.1	-2.2	-0.4
Medication: Gliclazide	1.1	1.2	2.5	-0.4	1.5	0.4	1.6
Illnesses of father: None of the above (group 1)	0.9	1.1	2.7	0.9	-1.6	-0.1	-0.8
Smoking status: Current	0.5	0.8	1.5	1.2	0.7	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.2	1.1	-0.4	1.1	-0.2
Whole body water mass	0.9	5.3	12.8	-0.9	-2.8	-0.3	-3.6
Leg predicted mass (right)	0.8	4.3	9.3	-0.7	-2.7	-0.3	-3.0
Arm fat mass (left)	0.2	0.9	2.1	0.1	-0.1	1.3	-1.4
Number of self-reported non-cancer illnesses	0.9	1.6	4.2	-2.0	0.4	-1.4	0.2
Average weekly champagne plus white wine intake	1.7	2.3	7.2	-1.2	-0.1	-2.7	0.8
Miserableness	0.1	0.2	0.3	-0.2	0.5	-0.2	-0.6
Guilty feelings	1.2	1.8	3.1	-1.8	-1.1	-1.5	0.8
Wears glasses or contact lenses	0.4	0.5	1.8	1.3	-0.3	0.3	0.0
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.8	0.5	-0.1	0.7
Hearing aid user	2.3	2.6	6.5	-0.9	-2.5	-1.7	0.1
Mother’s age at death	0.6	0.7	1.2	1.1	0.1	0.9	0.9
Financial situation satisfaction	0.4	0.5	1.4	-1.2	-0.0	-0.1	0.9
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.7	0.1	-1.9	-0.4	-1.6
Commuting to job workplace: Public transport	1.5	1.8	3.5	1.9	0.9	0.6	1.6
Eye problems/disorders: Glaucoma	1.6	1.9	5.8	-1.0	0.0	-2.4	0.9
Medication: Blood pressure	1.1	2.0	4.2	-0.8	-0.8	-1.6	-2.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-0.0	-1.0	-0.7	-1.3
Supplements: Fish oil (including cod liver oil)	2.2	2.9	5.1	-2.2	-0.1	-2.1	1.4
High cholesterol (Self-reported)	0.7	1.2	4.2	0.2	0.4	2.0	0.7
Medication: Bendroflumethiazide	2.2	3.3	6.6	1.6	-2.0	0.0	-2.6
Medication: Paracetamol	1.7	2.7	4.3	-1.3	-1.7	-2.1	-1.4
Medication: Lisinopril	0.7	1.0	1.4	0.7	-1.1	-1.2	-0.8
Medication: Atorvastatin	2.1	2.6	4.6	-0.9	-1.7	-2.1	-1.4
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.8	-0.1	-1.0	0.1
Alcohol drinker status: Never	0.2	0.2	0.8	-0.1	-0.9	0.2	-0.3
Ever smoked	0.1	0.1	0.3	-0.4	0.6	-0.0	0.2
Basal metabolic rate	0.9	4.7	11.8	-1.0	-2.5	-0.2	-3.4
Leg fat percentage (left)	0.5	1.8	3.3	0.6	0.9	1.6	-1.8
Arm fat-free mass (left)	0.7	3.7	10.4	-0.6	-2.0	0.3	-3.2
Number of operations (self-reported)	0.4	0.6	1.9	0.2	-0.4	0.4	-1.4
Average weekly beer plus cider intake	0.5	0.8	1.7	-1.3	1.0	0.6	0.3
Irritability	0.2	0.3	0.6	-0.5	0.6	-0.8	0.0
Risk taking	0.2	0.3	0.7	-0.6	0.9	-0.3	0.0
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.3	1.1	-1.5	1.5	-0.5
Fractured/broken bones in last 5 years	1.3	1.7	2.6	-0.1	-1.6	-1.3	-1.6
Age started oral contraceptive pill	0.2	0.3	0.6	0.4	0.2	0.8	0.6
Diastolic blood pressure, automated reading	0.9	2.9	6.8	-0.7	-1.8	-1.1	-2.6
Ever depressed for a whole week	1.9	2.3	3.3	1.8	1.4	1.8	0.8
Unable to work because of sickness or disability	1.1	1.4	2.3	1.3	-1.3	0.3	-1.5
Commuting to job workplace: Cycle	1.8	2.2	5.2	2.3	-0.9	1.7	-0.1
Myopia	0.7	1.0	2.0	0.5	-1.4	-0.7	-1.1
Vascular/heart problems diagnosed by doctor	1.2	3.3	6.9	0.6	2.3	0.8	2.6
Cholesterol lowering medication	0.4	0.6	2.0	0.1	0.7	1.4	0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.3	0.1	-0.9	-0.2	-1.5
Pain experienced in last month	0.5	0.8	1.8	0.2	-1.3	-1.2	0.4
Supplements: Calcium	0.4	0.5	1.2	-0.7	0.1	-0.4	1.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	1.6	0.1	1.6	0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.2	0.3	-1.4	0.0	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.4	0.1	-0.1	0.5
Heart disease (siblings)	0.2	0.3	0.6	-0.0	0.8	0.1	0.6
Alcohol drinker status: Previous	0.6	0.6	1.0	0.3	-0.8	1.0	-1.0
Pack years of smoking	0.4	0.7	2.1	0.1	-0.6	0.4	-1.4
Impedance of whole body	1.3	6.5	12.6	-3.5	-0.1	-3.4	1.3
Leg fat mass (left)	0.6	2.2	5.9	0.4	-0.1	1.7	-2.4
Arm predicted mass (left)	0.8	3.9	11.3	-0.5	-1.9	0.5	-3.4