Hub : Genes

ARAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.12 0.043 1.5e-03 0.000 NA 0.002 NA 0.003 2.9e-01 NA 1.9e-01 NA 1.7e-01
2 GTEx Esophagus Mucosa 0.27 0.051 8.0e-11 0.248 NA 0.216 NA 0.257 1.1e-16 NA 1.7e-14 NA 2.7e-17
3 GTEx Skin Not Sun Exposed Suprapubic 0.24 0.072 1.6e-05 0.195 NA 0.099 NA 0.161 6.0e-11 NA 4.3e-06 NA 3.6e-09
4 GTEx Skin Sun Exposed Lower leg 0.21 0.052 1.6e-06 0.127 NA 0.124 NA 0.127 1.2e-10 NA 2.0e-10 NA 1.2e-10
5 ROSMAP Brain Pre-frontal Cortex 0.05 0.021 1.4e-03 0.040 0.017 0.022 0.021 0.026 5.5e-06 0.0025 6.3e-04 0.00076 2.2e-04
6 YFS Blood 0.02 0.009 5.8e-03 0.011 0.005 0.001 0.005 0.007 8.1e-05 0.0079 1.5e-01 0.00790 2.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Alzheimer’s Disease (in mother) 0.5 0.6 1.5 -1.1 0.1 0.0 -0.1 0.8 1.2
Alzheimer’s Disease (in father) 0.4 0.4 1.9 -0.5 0.1 0.1 0.3 0.3 1.4
Alzheimer’s Disease (including proxy) 0.3 0.4 1.3 -1.0 -0.1 -0.1 -0.1 0.5 1.2
Crohns Disease (2017) 2.5 5.5 7.3 2.4 -2.5 -2.7 -2.7 2.0 -1.6
Irritable Bowel Disease (IBD) 0.7 1.6 3.7 1.9 -1.1 -1.2 -1.1 1.1 -1.0
Ulcerative Colitis (UC) 0.1 0.3 0.6 0.8 0.5 0.5 0.7 0.1 0.0
Major Depression (MDD) 0.5 0.6 2.4 -1.0 0.2 -0.1 -0.3 -0.0 -1.6
Reaction Time 1.3 2.5 5.5 -2.4 1.7 1.8 1.9 -0.1 0.1
Verbal and Numeric Reasoning (VNR) 1.1 2.7 4.3 1.1 -2.1 -2.0 -1.8 1.9 -0.4
Breast Cancer 2.1 5.1 7.4 2.5 -2.7 -2.7 -2.6 1.3 -0.7
Ovarian Cancer 0.1 0.1 0.3 -0.5 0.0 0.0 -0.1 -0.5 0.5
Prostate Cancer 0.5 0.8 2.6 -0.4 0.2 0.2 0.1 1.3 1.6
Age at First Birth 3.1 4.6 7.5 2.1 -2.7 -2.7 -2.5 1.4 -0.3
Bipolar Disorder 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.5 2.1 3.7 -1.6 1.9 1.9 1.6 -0.4 0.4
Coronary Artery Disease (CAD) 0.9 1.0 1.4 0.5 1.2 1.2 1.2 -1.0 -0.9
Crohns Disease (2012) 1.3 2.1 4.8 -0.9 1.4 1.4 1.4 -2.2 1.0
Mean Putamen Volume 0.3 0.3 1.3 -0.4 -0.1 0.0 0.2 -0.5 -1.1
Fasting Glucose 6.5 7.8 11.2 3.0 -2.6 -3.1 -3.0 -1.2 -3.4
HbA1C 4.4 4.9 6.5 2.0 -2.4 -2.5 -2.5 1.4 -2.2
HDL Cholesterol 0.5 0.9 3.2 1.8 0.3 0.2 0.2 -0.2 -1.3
LDL Cholesterol 0.1 0.1 0.4 0.2 0.1 -0.0 -0.2 0.3 -0.6
Lupus 0.9 1.4 5.5 -2.3 0.8 0.9 0.6 0.1 1.1
Neuroticism 1.2 1.7 4.0 -2.0 1.4 1.3 1.2 -1.0 0.5
Primary Biliary Cirrhosis 1.6 2.3 9.1 -0.7 1.2 0.9 0.9 -3.0 -1.1
Rheumatoid Arthritis 0.4 0.6 1.2 -1.1 0.6 0.8 0.7 -0.2 0.9
Schizophrenia 1.2 2.6 4.6 1.0 -1.8 -1.8 -2.1 1.9 0.1
Triglycerides 0.2 0.4 2.2 -0.1 0.0 0.0 -0.0 0.2 1.5
Type 2 Diabetes (T2D) 7.1 8.3 16.7 4.1 -2.6 -3.0 -2.8 0.1 -3.2
Ulcerative Colitis 0.3 0.4 0.8 -0.9 -0.6 -0.6 -0.9 0.6 -0.1
Blood Eosinophil Count 0.5 4.0 9.2 -0.5 1.8 1.8 1.9 -3.0 2.2
Blood Platelet Count 2.1 24.2 35.3 -2.0 5.9 5.5 5.6 -5.6 -3.6
Blood Red Count 0.0 0.2 0.7 0.2 -0.3 -0.4 -0.5 -0.9 0.2
Blood White Count 1.1 7.8 12.4 -0.5 3.5 3.3 3.3 -3.4 -1.2
Heel T-Score 2.4 19.5 31.9 3.6 -5.6 -5.7 -5.2 2.9 -2.4
BMI 2.3 13.9 22.4 -2.8 4.6 4.7 4.7 -2.7 1.5
Height 1.0 19.5 31.5 -3.9 5.6 5.5 5.6 -3.0 0.1
Waist Hip Ratio (WHR) 0.5 2.1 4.5 2.1 -1.2 -1.4 -1.4 1.5 -0.5
Systolic Blood Pressure 0.0 0.2 0.8 -0.1 -0.4 -0.3 -0.4 -0.0 -0.9
Smoking Status 4.2 10.2 16.3 -3.0 4.0 4.0 3.8 -2.2 0.6
Allergy or Eczema 2.6 6.8 10.6 2.1 -3.0 -3.3 -3.2 1.7 -1.9
Cardiovascular Disease 0.2 0.6 1.6 -1.2 0.5 0.5 0.6 0.5 -1.0
Hypothyroidism (self reported) 1.1 2.6 7.7 -2.2 -0.1 0.2 -0.1 1.7 2.8
Respiratory disease 0.6 1.4 2.2 -0.1 -1.0 -1.3 -1.4 1.3 -1.5
Type 2 Diabetes (T2D) 7.5 14.0 29.4 5.4 -3.3 -3.9 -3.7 -1.3 -3.6
Lung FEV1/FVC ratio 6.9 35.0 43.8 -6.0 6.4 6.6 6.1 -4.8 5.3
Lung FVC 2.6 13.5 17.0 3.7 -4.0 -4.1 -3.8 1.8 -4.1
Neuroticism 0.4 1.0 2.8 -1.7 0.4 0.5 0.1 1.1 1.3
Chronotype (morning person) 3.2 7.5 10.3 -2.4 3.0 3.2 3.2 -0.8 3.0
Hair Pigment 0.0 0.2 0.3 -0.5 0.5 0.4 0.4 0.2 0.3
Tanning 0.0 0.4 1.2 1.1 -0.2 -0.3 -0.3 0.2 1.0
Hand grip strength (left) 0.1 0.2 0.6 0.8 -0.4 -0.5 -0.4 0.4 -0.2
Number of treatments/medications taken 1.7 3.1 4.1 -0.6 2.0 2.0 1.8 -2.0 1.7
Average weekly spirits intake 0.7 0.9 4.2 0.2 -0.4 -0.4 -0.2 -0.8 -2.1
Sensitivity / hurt feelings 0.2 0.4 1.9 1.4 -0.2 -0.3 -0.3 -0.4 -0.4
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 0.7 -0.2 -0.2 0.0 0.7 -0.4
Hearing difficulty/problems: Yes 0.2 0.3 1.8 0.1 -0.2 -0.2 -0.1 0.2 -1.3
Relative age of first facial hair 1.5 3.1 6.8 -1.3 1.8 1.8 1.9 -2.6 -0.7
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 3.4 1.9 -0.5 -0.4 -0.3 -1.2 0.4
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.3 -0.6 0.5 0.4 0.6 -1.8 -1.3
Ever had hysterectomy (womb removed) 2.4 2.7 4.0 -1.8 1.7 1.9 2.0 -1.5 -0.6
Systolic blood pressure, automated reading 0.4 1.0 1.7 1.1 -1.1 -1.3 -1.3 0.5 -0.1
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 2.9 -0.7 1.6 1.7 1.7 -1.5 -0.9
Angina 1.0 1.3 2.0 1.4 -1.3 -1.3 -1.4 0.6 0.0
Medication for hormone replacement therapy 0.2 0.2 0.6 0.8 -0.4 -0.3 -0.3 0.2 0.3
Vitamin and mineral supplements 0.4 0.6 0.7 0.1 -0.8 -0.8 -0.9 0.8 -0.8
Supplements: Zinc 0.1 0.1 0.3 -0.2 0.1 0.2 0.2 -0.5 0.4
Medication: Co-codamol 0.0 0.1 0.1 0.1 -0.3 -0.3 -0.3 0.2 -0.0
Medication: Metformin 6.9 9.6 20.2 -4.5 3.3 3.7 3.5 -0.2 1.1
Diabetes (father) 1.2 1.5 4.3 -2.1 0.9 1.0 0.9 0.2 1.4
Diabetes (mother) 8.1 10.4 22.7 -4.8 2.9 3.2 3.0 -1.3 3.1
Severe depression (siblings) 0.8 0.9 1.9 0.8 0.8 0.8 0.8 -1.4 -0.8
Pack years adult smoking proportion 0.4 0.7 2.4 0.7 -0.5 -0.5 -0.5 0.7 -1.5
Impedance of leg (right) 1.5 7.5 10.9 -2.4 2.8 2.9 2.7 -2.2 3.3
Leg fat-free mass (left) 3.8 20.8 31.3 3.9 -5.5 -5.6 -5.3 3.3 -2.8
Trunk fat percentage 1.8 7.2 12.9 1.9 -3.6 -3.5 -3.4 1.1 -1.2
Hand grip strength (right) 0.2 0.7 1.0 0.9 -0.7 -0.8 -0.8 0.8 -1.0
Townsend deprivation index at recruitment 0.2 0.2 0.5 0.6 -0.7 -0.6 -0.6 -0.1 -0.0
Current tobacco smoking 1.9 3.2 5.6 0.9 -2.4 -2.3 -2.2 0.5 -1.5
Average weekly fortified wine intake 0.4 0.5 0.8 -0.4 0.8 0.9 0.8 0.8 0.4
Maternal smoking around birth 2.7 3.9 6.1 2.0 -2.5 -2.4 -2.1 1.5 -0.8
Fed-up feelings 1.1 2.0 3.4 1.0 -1.7 -1.6 -1.4 1.8 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.2 1.0 -0.7 -0.7 -0.3 1.1 -0.5
Relative age voice broke 2.7 4.3 6.3 -2.5 2.3 2.3 2.2 -1.9 0.5
Taking other prescription medications 1.1 1.7 6.4 0.6 1.0 1.0 1.1 -2.5 0.7
Age when periods started (menarche) 0.0 0.1 0.4 0.3 -0.1 -0.2 -0.3 -0.6 0.2
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.0 -1.4 1.2 1.2 1.3 -0.4 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 5.2 0.3 2.3 2.2 2.1 -2.1 -0.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.5 0.9 -0.7 -0.8 -1.0 -0.4 -1.2
Qualifications: CSEs or equivalent 1.4 1.8 2.9 1.4 -1.7 -1.6 -1.4 1.1 -0.6
Serious illness, injury or assault to yourself 0.8 0.9 2.8 1.7 -0.8 -0.9 -0.8 -0.5 -0.6
High blood pressure 0.3 0.9 1.5 0.5 -1.0 -1.1 -1.2 0.1 1.1
Hayfever, allergic rhinitis or eczema 2.1 4.5 5.8 -2.2 2.0 2.4 2.4 -1.5 2.1
Multivitamins +/- minerals 0.2 0.3 0.6 0.0 0.5 0.5 0.5 -0.8 0.6
Stomach or abdominal pain in last month 0.3 0.4 2.2 -0.1 -0.2 -0.2 -0.3 1.5 0.4
Supplements: Glucosamine 0.2 0.2 1.2 -0.2 0.0 -0.1 -0.1 -1.1 -0.5
Diverticular disease/diverticulitis (self-reported) 4.1 4.9 6.8 -2.1 1.9 2.0 2.1 -2.6 2.4
Medication: Atenolol 0.1 0.1 0.6 -0.2 -0.0 -0.0 -0.1 0.0 0.8
Medication: Levothyroxine sodium 0.8 1.3 3.8 0.9 0.2 0.1 0.4 -1.7 -2.0
Sitting height 0.7 5.3 7.2 1.7 -2.6 -2.7 -2.7 2.3 -1.6
Chronic bronchitis/emphysema (father) 1.3 1.6 2.7 -1.6 1.1 1.2 1.1 -1.5 -0.7
High blood pressure (mother) 0.6 0.8 1.6 -1.3 1.1 0.9 0.9 -0.5 -0.2
Body mass index (BMI) 1.6 7.1 12.0 2.0 -3.5 -3.4 -3.2 1.6 -1.4
Impedance of leg (left) 1.6 7.9 10.7 -2.7 2.9 3.0 2.9 -1.9 3.3
Leg predicted mass (left) 3.8 20.3 30.7 3.9 -5.5 -5.5 -5.3 3.2 -2.9
Trunk fat mass 2.7 11.7 20.1 2.5 -4.5 -4.4 -4.3 1.8 -1.6
Waist circumference 2.1 7.8 13.5 2.3 -3.7 -3.6 -3.4 1.2 -1.2
Number of incorrect matches in round 0.2 0.3 1.1 -1.1 0.1 0.2 -0.1 -0.4 0.9
Past tobacco smoking 2.0 3.8 7.3 -2.7 2.3 2.3 2.1 -0.4 -0.7
Alcohol usually taken with meals 0.8 1.4 2.2 -1.0 1.4 1.5 1.4 -0.6 0.7
Nervous feelings 0.1 0.1 0.4 0.6 -0.2 -0.3 -0.1 0.3 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.6 0.7 0.2 0.2 0.5 -0.2 -0.4
Hearing difficulty/problems with background noise 1.0 1.6 3.3 1.8 -1.3 -1.3 -1.1 1.3 0.2
Hair/balding pattern: Pattern 2 0.7 0.9 2.2 -0.7 -0.9 -0.9 -1.1 1.5 -0.4
Had menopause 4.1 5.2 7.0 -2.6 2.5 2.6 2.6 -1.7 1.3
Had other major operations 1.2 1.4 2.5 -0.6 0.9 1.0 1.3 -1.6 1.5
Forced vital capacity (FVC) 0.2 0.7 3.2 -0.3 0.2 0.3 0.0 0.7 1.8
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 8.7 0.3 2.5 2.3 2.3 -2.9 -0.6
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.7 -0.1 1.1 1.3 1.3 -0.9 1.1
Qualifications: None of the above 1.0 2.2 3.4 1.3 -1.8 -1.9 -1.7 -0.3 -1.2
Financial difficulties in last 2 years 3.5 4.7 8.8 2.4 -3.0 -2.7 -2.3 0.8 0.6
Mouth/teeth dental problems 2.7 4.1 7.8 -2.8 2.0 2.0 2.1 -1.8 1.0
Heart attack 0.2 0.2 0.5 0.7 -0.6 -0.5 -0.4 -0.1 -0.0
Allergy 1.9 4.4 6.3 1.7 -2.0 -2.4 -2.5 1.9 -2.0
Pain all over the body in last month 1.9 2.1 7.3 0.6 -1.4 -1.1 -0.9 0.8 2.7
Diabetes (self-reported) 3.8 5.9 16.1 -4.0 2.1 2.5 2.4 0.8 1.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.5 -0.3 0.4 0.5 0.4 0.5 1.6
Medication: Ramipril 0.2 0.3 0.8 -0.9 0.5 0.5 0.5 0.4 0.0
Medication: Simvastatin 0.2 0.3 0.9 0.7 -0.5 -0.6 -1.0 -0.0 0.3
Fluid intelligence score 1.7 3.5 4.2 -2.0 2.1 2.1 1.8 -2.0 0.9
Illnesses of siblings 0.4 0.6 1.4 0.2 -0.8 -0.8 -0.6 0.8 -1.2
Neuroticism score 0.4 0.8 2.1 1.4 -0.9 -0.9 -0.6 -0.0 -0.8
Weight 2.9 14.4 23.8 3.1 -4.9 -4.8 -4.7 2.3 -1.6
Impedance of arm (right) 0.3 1.5 2.3 -1.5 1.2 1.2 1.2 -1.4 0.5
Arm fat percentage (right) 1.4 5.8 10.3 1.2 -3.2 -3.2 -3.0 0.7 -1.7
Trunk fat-free mass 1.6 9.2 14.4 2.2 -3.8 -3.8 -3.6 2.6 -1.4
Hip circumference 3.7 16.2 24.6 3.7 -4.9 -5.0 -4.8 2.9 -1.8
Time employed in main current job 4.3 5.0 7.6 -2.2 2.5 2.5 2.3 -2.8 -0.0
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.4 0.3 0.3 -0.1 -0.1 -0.4
Father’s age at death 0.9 1.2 1.8 -1.3 1.1 1.1 1.2 -1.4 -0.3
Worrier / anxious feelings 0.2 0.4 1.2 0.5 -0.5 -0.6 -0.4 -0.7 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.4 0.7 0.2 0.1 0.4 -0.0 -1.5
Falls in the last year 0.5 0.7 1.3 -0.4 0.7 0.8 0.9 -1.0 1.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 -0.8 0.1 0.0 -0.1 -0.5 0.6
Number of live births 0.2 0.3 0.7 0.8 -0.3 -0.3 -0.2 -0.7 -0.8
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 4.3 1.4 -1.6 -1.7 -1.8 2.1 0.1
Pulse rate 2.7 4.6 7.4 1.2 -2.5 -2.5 -2.7 2.5 -0.6
Happiness 0.8 1.0 2.0 1.4 -1.1 -1.1 -0.9 0.6 0.6
Noisy workplace 0.7 0.9 1.9 1.4 -0.8 -0.7 -0.6 1.2 0.6
Qualifications: A levels/AS levels or equivalent 1.8 4.1 7.5 -1.4 2.7 2.7 2.6 -0.9 0.4
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 6.6 -0.5 -0.8 -0.8 -1.0 1.7 2.6
Mouth/teeth dental problems: Dentures 5.3 9.0 11.7 3.2 -3.3 -3.4 -3.3 1.6 -2.9
Asthma 0.3 0.7 2.0 0.5 0.5 0.6 0.6 -0.9 1.4
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.5 4.3 1.0 -1.9 -1.9 -2.1 1.3 0.4
Medication: Cholesterol lowering 0.3 0.5 1.6 -0.3 0.8 0.8 0.4 -0.2 1.3
Depression (self-reported) 0.3 0.3 1.0 0.8 -0.3 -0.3 -0.3 -0.4 -1.0
Medication: Lansoprazole 0.4 0.4 0.9 0.5 -0.6 -0.6 -0.6 -0.4 0.9
Prospective memory result 1.0 1.2 2.1 0.6 -1.4 -1.5 -1.4 0.5 -0.7
Lung cancer (father) 1.1 1.3 2.3 1.0 -1.5 -1.5 -1.5 0.3 0.1
Illnesses of mother 1.1 1.3 4.3 2.1 -1.1 -1.1 -1.0 0.2 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 3.7 0.8 -1.1 -1.2 -1.2 1.9 0.3
Pulse wave Arterial Stiffness index 0.3 0.3 1.6 -1.3 -0.2 -0.1 -0.0 0.4 -0.3
Impedance of arm (left) 0.1 0.4 0.6 -0.6 0.5 0.6 0.4 -0.8 0.7
Arm fat mass (right) 2.3 9.9 17.6 2.0 -4.2 -4.1 -4.0 1.8 -1.4
Trunk predicted mass 1.6 9.2 14.7 2.2 -3.8 -3.8 -3.6 2.6 -1.4
Standing height 1.1 10.9 17.2 2.7 -4.1 -4.2 -4.1 2.4 -0.8
Length of working week for main job 1.0 1.1 4.8 0.5 -0.6 -0.7 -0.7 -0.3 -2.2
Exposure to tobacco smoke at home 0.2 0.3 0.7 -0.5 0.4 0.5 0.4 -0.8 -0.3
Breastfed as a baby 1.5 1.9 3.1 -0.8 1.7 1.7 1.8 -0.9 -1.0
Tense / ‘highly strung’ 0.5 0.8 1.8 0.0 0.9 0.8 0.9 -1.3 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 7.4 2.7 -1.7 -1.9 -1.8 0.6 0.3
Hair/balding pattern: Pattern 4 1.9 4.9 8.8 -1.1 2.9 3.0 3.0 -1.4 0.6
Birth weight of first child 0.6 1.0 4.1 -1.0 -0.6 -0.5 -0.5 2.0 0.6
Peak expiratory flow (PEF) 0.8 1.8 3.0 0.8 -1.5 -1.4 -1.4 1.7 -0.8
Pulse wave reflection index 2.9 3.5 5.0 -1.7 1.9 2.0 2.2 -1.9 1.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.9 -0.8 -0.3 -0.1 -0.0 0.5 1.4
Loud music exposure frequency 1.1 1.2 4.3 -2.1 0.2 0.4 0.5 0.9 -1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.6 0.4 -0.1 -0.1 -0.1 0.7 1.6
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 0.3 -0.1 -0.1 -0.1 0.1 -0.1
Blood clot in the leg (DVT) 0.3 0.4 1.3 0.5 -0.4 -0.3 -0.2 -1.2 0.9
Medication: Paracetamol 0.4 0.7 3.0 1.0 -0.3 -0.1 0.0 -0.4 1.7
Headache pain in last month 1.4 2.4 5.3 -0.4 1.8 1.8 1.6 -0.4 2.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 4.1 0.5 -0.7 -0.7 -0.2 -0.2 -2.0
Glaucoma (self-reported) 0.0 0.1 0.1 -0.1 0.1 0.2 0.3 0.3 -0.3
Gout (self-reported) 0.2 0.3 1.3 0.6 0.1 0.0 -0.0 -0.5 1.2
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 6.3 1.5 0.2 -0.0 0.2 -1.7 -2.5
Medication: Amlodipine 0.3 0.4 1.1 1.1 0.3 0.1 0.3 -0.3 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.2 -0.0 -0.5 -0.2 0.0 -0.9 1.1
Birth weight 0.1 0.2 0.8 0.2 -0.1 0.1 0.3 0.9 0.4
Chronic bronchitis/emphysema (mother) 0.9 1.0 5.8 -0.5 -0.3 -0.3 -0.1 -2.4 0.2
High blood pressure (siblings) 0.1 0.2 0.5 -0.4 0.4 0.3 0.3 -0.3 0.7
Forced vital capacity (FVC), Best measure 0.3 1.0 3.7 -0.9 0.6 0.6 0.5 0.7 1.9
Body fat percentage 1.4 5.8 10.6 1.7 -3.3 -3.2 -3.1 0.7 -1.1
Leg fat percentage (right) 0.6 2.1 4.3 0.9 -2.1 -2.0 -1.9 -0.1 -0.4
Arm fat-free mass (right) 2.5 12.9 19.6 3.0 -4.4 -4.4 -4.2 3.2 -1.2
Exposure to tobacco smoke outside home 0.8 1.0 2.2 -1.5 1.1 1.1 1.0 -0.7 -0.1
Comparative body size at age 10 0.5 1.5 2.8 -0.2 -1.7 -1.5 -1.1 1.5 0.8
Number of full brothers 1.0 1.3 7.0 0.5 0.5 0.4 0.4 -0.3 -2.6
Worry too long after embarrassment 1.5 2.6 4.1 1.9 -2.0 -2.0 -1.8 0.7 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.3 0.9 -0.8 -0.8 -0.5 0.5 -1.2
Wheeze or whistling in the chest in last year 0.5 0.8 3.1 0.7 -0.7 -0.5 -0.2 -1.8 0.7
Number of children fathered 4.8 5.4 8.5 1.8 -2.6 -2.8 -2.9 2.2 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 3.3 3.9 7.9 -0.7 2.5 2.5 2.8 -1.6 0.4
Age at first live birth 2.4 4.2 7.3 -1.4 2.7 2.6 2.6 -1.6 0.4
Pulse wave peak to peak time 0.3 0.4 2.0 1.4 -0.1 -0.2 -0.3 -0.1 0.2
Health satisfaction 1.3 1.6 4.3 2.1 -1.2 -1.2 -1.2 0.6 0.8
Shortness of breath walking on level ground 0.7 0.8 2.7 -1.4 -0.1 0.3 0.4 -0.2 1.6
Qualifications: College or University degree 2.8 9.0 15.5 -1.5 3.9 3.8 3.8 -2.6 -0.4
Eye problems/disorders: None of the above 0.9 1.0 2.1 1.5 -0.9 -1.0 -1.1 0.6 0.9
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.4 -0.3 1.1 1.0 1.0 -1.2 -0.9
Emphysema/chronic bronchitis 1.0 1.1 1.6 -1.2 1.0 1.1 1.3 -1.0 0.5
Medication for pain relief, constipation, heartburn 1.0 1.7 9.0 -0.8 0.5 0.3 0.2 -0.1 -3.0
Neck or shoulder pain in last month 0.4 0.6 3.0 -0.6 0.0 0.0 -0.1 0.5 1.7
Medication: Blood pressure 0.7 1.2 4.7 -1.1 0.7 0.7 0.3 0.4 2.2
Angina (self-reported) 1.5 2.0 3.3 1.4 -1.7 -1.7 -1.8 0.9 0.3
Migraine (self-reported) 2.2 2.8 6.5 -0.8 1.8 1.7 1.6 -2.5 -1.0
Medication: Ibuprofen 1.7 2.1 3.5 1.2 -1.7 -1.8 -1.9 1.3 0.0
Medication: Allopurinol 0.5 0.7 3.4 -0.2 -0.4 -0.4 -0.6 -0.2 1.9
Medication: Omeprazole 1.0 1.2 2.3 1.5 -1.2 -1.0 -1.1 -0.2 1.1
Medication: Seretide 50 evohaler 1.4 1.6 2.5 -1.1 1.3 1.4 1.6 -1.1 1.0
Mean time to correctly identify matches 0.2 0.4 1.2 1.1 -0.3 -0.4 -0.5 -0.8 -0.0
Heart disease (mother) 0.7 0.8 1.3 0.5 -1.2 -1.1 -1.2 0.9 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.5 1.0 -1.4 -1.5 -1.6 0.2 -0.2
Whole body fat mass 2.6 11.1 18.8 2.5 -4.3 -4.3 -4.2 1.7 -1.6
Leg fat mass (right) 2.2 8.6 14.5 2.6 -3.8 -3.8 -3.6 1.1 -1.2
Arm predicted mass (right) 2.1 11.1 16.7 2.8 -4.1 -4.1 -3.9 3.0 -1.2
Pulse rate, automated reading 3.6 11.8 16.6 3.3 -3.8 -4.0 -4.1 2.3 -2.8
Alcohol intake frequency. 1.0 2.3 4.1 2.0 -1.4 -1.5 -1.5 1.6 -1.0
Comparative height size at age 10 0.5 2.6 5.5 0.3 -2.3 -2.2 -2.2 0.8 -0.5
Number of full sisters 2.6 3.1 5.1 2.3 -2.1 -2.0 -1.9 1.3 0.5
Suffer from ‘nerves’ 0.2 0.3 0.5 0.3 -0.7 -0.7 -0.7 0.5 -0.4
Overall health rating 2.2 4.8 9.6 3.1 -2.5 -2.4 -2.3 1.3 0.3
Chest pain or discomfort 0.2 0.3 0.5 0.1 -0.7 -0.7 -0.6 -0.3 0.2
Had major operations 0.5 0.6 2.1 0.3 -0.6 -0.7 -0.7 0.4 -1.4
Age at last live birth 0.5 0.7 1.6 -0.3 1.2 1.0 0.8 -0.6 -0.6
Family relationship satisfaction 0.3 0.4 1.9 1.4 -0.2 -0.2 -0.1 0.2 0.2
Leg pain on walking 0.3 0.4 1.8 0.1 -0.4 -0.4 -0.4 1.4 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.4 -0.1 -0.1 -0.0 -0.2 0.5 1.6
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.7 1.4 -0.1 -0.2 -0.0 -1.6 -1.6
Illness, injury, bereavement, stress in last 2 years 8.1 10.0 14.4 -3.2 3.8 3.8 3.8 -2.6 -0.7
Medication: Aspirin 0.6 0.8 2.2 -0.9 0.6 0.7 0.7 -0.5 1.5
Supplements: Vitamin C 0.6 0.7 1.8 0.0 1.0 1.1 1.4 0.0 0.2
Knee pain experienced in last month 0.7 1.1 1.6 0.8 -1.1 -1.0 -1.1 0.9 1.3
Hypertension (Self-reported) 0.4 1.0 1.7 0.8 -1.1 -1.2 -1.3 0.1 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.1 -0.3 0.4 0.6 0.6 0.3 1.4
Illnesses of father: Heart disease 1.8 2.4 4.7 -0.8 2.2 2.1 1.9 -0.6 0.9
Illnesses of siblings: Diabetes 5.8 7.2 11.6 -2.4 3.2 3.4 3.2 -1.6 1.6
Smoking status: Previous 1.1 1.6 2.6 1.3 -1.4 -1.3 -1.1 0.8 1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 4.1 2.0 -1.7 -1.8 -1.8 0.9 -0.8
Whole body fat-free mass 2.4 14.1 21.5 3.0 -4.6 -4.6 -4.4 3.0 -2.1
Leg fat-free mass (right) 3.6 19.8 29.4 3.8 -5.3 -5.4 -5.2 3.4 -3.0
Arm fat percentage (left) 1.8 7.2 12.3 1.6 -3.5 -3.5 -3.4 1.1 -1.8
Average weekly red wine intake 0.3 0.4 1.1 -1.1 -0.0 0.1 0.0 0.6 1.0
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.9 0.9 -0.2 -0.1 -0.0 -0.4 0.2
Mood swings 0.7 1.3 3.5 1.9 -1.3 -1.2 -0.9 0.4 -0.5
Loneliness, isolation 0.6 0.8 2.6 0.9 -0.6 -0.6 -0.5 -0.5 -1.6
Long-standing illness, disability or infirmity 1.1 1.8 3.0 -0.6 1.2 1.4 1.3 -1.5 1.7
Ever had bowel cancer screening 0.9 1.1 2.1 -0.0 1.4 1.3 1.4 -0.2 -0.9
Diabetes diagnosed by doctor 5.6 9.2 21.2 -4.6 2.9 3.3 3.2 0.3 2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.3 -1.5 0.2 0.4 0.2 0.7 0.6
Friendships satisfaction 0.4 0.5 2.3 1.5 -0.1 -0.2 -0.1 -0.7 -0.5
Qualifications: nursing, teaching 3.7 5.9 9.2 -2.8 3.0 2.9 3.0 -0.8 0.2
Commuting to job workplace: Walk 0.4 0.5 2.4 -0.1 -0.2 -0.2 -0.2 0.6 1.5
Eye problems/disorders: Cataract 0.4 0.5 1.0 -0.9 0.4 0.6 0.7 -1.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.6 0.4 0.4 0.5 0.4 0.6
Medication for cholesterol 0.1 0.1 0.2 -0.3 -0.4 -0.4 -0.4 0.4 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.3 -1.5 0.9 1.0 1.0 -0.8 1.3
Back pain experienced in last month 0.4 0.5 1.0 0.6 -0.8 -1.0 -0.9 -0.3 -0.6
Mineral and other dietary supplements 0.3 0.3 0.7 -0.3 -0.5 -0.5 -0.5 0.7 -0.8
Breast cancer (self-reported) 1.5 1.8 2.7 1.1 -1.6 -1.6 -1.5 1.5 -0.2
Asthma (self-reported) 0.3 0.6 2.4 0.8 0.2 0.4 0.4 -0.6 1.6
Osteoporosis (self-reported) 0.1 0.2 0.4 0.0 -0.6 -0.6 -0.5 0.2 -0.1
Osteoarthritis (self-reported) 0.1 0.1 0.3 0.5 0.0 0.0 -0.1 -0.3 0.6
Medication: Aspirin 0.8 1.1 3.0 -1.1 0.7 0.8 0.8 -0.8 1.7
Medication: Gliclazide 6.1 6.8 11.9 -3.5 3.0 3.1 2.7 -1.4 1.1
Illnesses of father: None of the above (group 1) 2.9 3.6 5.0 1.9 -2.2 -2.2 -2.0 1.0 -1.8
Smoking status: Current 2.3 3.7 6.7 1.2 -2.6 -2.5 -2.4 0.6 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 1.8 -1.3 0.7 0.6 0.6 0.3 -0.3
Whole body water mass 2.4 13.9 21.3 3.0 -4.6 -4.6 -4.4 3.0 -2.0
Leg predicted mass (right) 3.6 19.8 29.5 3.7 -5.4 -5.4 -5.2 3.4 -3.0
Arm fat mass (left) 2.3 9.6 16.2 2.1 -4.0 -4.0 -3.8 1.9 -1.5
Number of self-reported non-cancer illnesses 0.7 1.2 3.2 0.3 0.9 1.0 1.0 -1.8 1.2
Average weekly champagne plus white wine intake 0.3 0.4 0.9 -0.7 0.5 0.6 0.7 0.1 1.0
Miserableness 1.9 3.3 8.4 2.9 -2.0 -2.0 -1.6 0.3 -0.9
Guilty feelings 0.1 0.1 0.3 0.1 -0.4 -0.3 0.0 0.1 0.6
Wears glasses or contact lenses 2.7 3.1 3.8 -1.7 1.6 1.6 1.7 -1.9 -1.9
Ever taken oral contraceptive pill 0.7 0.8 1.9 -0.3 0.8 0.9 1.0 -1.4 0.4
Hearing aid user 0.2 0.2 0.9 0.4 -0.1 -0.1 -0.0 0.2 -0.9
Mother’s age at death 4.4 5.5 8.6 -2.9 2.7 2.8 2.7 -1.1 0.9
Financial situation satisfaction 0.3 0.4 1.4 1.2 0.1 0.0 0.3 -0.9 -0.4
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.4 0.7 -1.4 -1.4 -1.1 1.0 -1.6
Commuting to job workplace: Public transport 1.5 1.8 5.1 -2.3 1.2 1.3 1.5 -0.6 -0.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.1 0.4 0.4 0.6 -0.0 0.4
Medication: Blood pressure 0.3 0.6 1.7 -0.6 0.5 0.6 0.6 -0.8 1.3
Pain type(s) experienced in last month: Hip pain 0.6 0.8 3.1 1.1 0.1 -0.0 0.0 -0.7 -1.8
Supplements: Fish oil (including cod liver oil) 2.0 2.6 4.1 -0.3 1.9 1.9 1.7 -1.3 2.0
High cholesterol (Self-reported) 0.9 1.6 2.6 -0.8 1.6 1.5 1.3 -1.6 -0.3
Medication: Bendroflumethiazide 0.8 1.2 3.5 -1.3 0.9 0.9 0.7 -0.2 1.9
Medication: Paracetamol 0.3 0.5 2.8 0.5 -0.3 -0.1 0.1 -0.3 1.7
Medication: Lisinopril 0.7 1.0 3.3 -0.9 0.7 0.6 0.5 -1.8 -0.8
Medication: Atorvastatin 0.9 1.1 1.8 -0.5 1.2 1.3 1.1 0.2 1.4
Illnesses of father: High blood pressure 0.1 0.2 0.7 -0.0 0.2 0.1 0.2 -0.8 -0.5
Alcohol drinker status: Never 0.5 0.6 3.0 0.5 -0.3 -0.2 -0.3 1.7 0.4
Ever smoked 0.9 1.6 2.6 1.4 -1.5 -1.6 -1.5 -0.6 0.2
Basal metabolic rate 2.8 15.8 24.6 3.2 -5.0 -5.0 -4.7 3.0 -2.0
Leg fat percentage (left) 0.6 2.3 4.7 0.8 -2.2 -2.1 -1.9 0.2 -0.5
Arm fat-free mass (left) 2.0 10.3 16.3 2.3 -4.0 -4.0 -3.8 2.8 -1.3
Number of operations (self-reported) 0.4 0.6 1.4 0.4 -0.7 -0.7 -0.6 1.2 0.8
Average weekly beer plus cider intake 0.6 0.8 3.0 1.7 -0.5 -0.6 -0.5 0.7 -0.7
Irritability 0.0 0.0 0.1 0.3 -0.0 0.0 0.1 0.2 -0.2
Risk taking 1.5 2.2 4.3 0.2 -1.8 -1.6 -1.7 2.1 -0.2
Ever had prostate specific antigen (PSA) test 3.5 4.0 6.2 -1.8 2.4 2.5 2.5 -1.2 1.0
Fractured/broken bones in last 5 years 1.0 1.3 1.6 -1.3 1.2 1.2 1.3 -0.8 0.9
Age started oral contraceptive pill 5.9 7.4 9.7 -2.9 3.0 3.1 3.0 -1.8 2.2
Diastolic blood pressure, automated reading 0.4 1.4 2.3 1.4 -1.4 -1.5 -1.3 0.4 -0.1
Ever depressed for a whole week 0.7 0.8 1.3 -0.7 1.0 1.1 1.1 -0.7 0.7
Unable to work because of sickness or disability 1.6 2.1 4.3 2.1 -1.0 -1.0 -0.8 -1.2 -2.0
Commuting to job workplace: Cycle 2.0 2.5 3.9 -1.5 1.8 1.9 2.0 -0.1 1.3
Myopia 2.1 3.0 7.7 -0.3 1.4 1.4 1.5 -2.1 -2.8
Vascular/heart problems diagnosed by doctor 0.4 1.0 1.8 -0.9 1.1 1.1 1.4 0.1 -1.1
Cholesterol lowering medication 0.2 0.3 0.8 -0.2 0.6 0.6 0.5 -0.5 -0.9
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 5.3 2.3 -1.4 -1.3 -1.4 0.5 1.1
Pain experienced in last month 1.3 2.1 4.1 -0.6 1.2 1.2 1.3 -1.9 -2.0
Supplements: Calcium 1.3 1.4 2.4 -1.2 1.3 1.4 1.5 0.2 0.8
Basal cell carcinoma (self-reported) 2.1 2.6 4.2 -2.0 1.7 1.8 2.0 -1.0 -0.2
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.4 0.6 -0.7 -0.5 -0.4 0.0 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.9 0.7 -0.8 -0.7 -0.5 -1.0 0.7
Heart disease (siblings) 1.9 2.4 3.7 1.7 -1.7 -1.8 -1.9 1.2 -0.5
Alcohol drinker status: Previous 0.6 0.7 3.8 2.0 -0.1 -0.2 -0.1 -0.2 0.1
Pack years of smoking 0.4 0.5 2.6 0.4 -0.2 -0.2 -0.1 0.6 -1.6
Impedance of whole body 0.6 3.0 4.3 -1.8 1.8 1.9 1.7 -1.1 2.1
Leg fat mass (left) 2.2 8.6 14.3 2.6 -3.8 -3.8 -3.6 1.2 -1.3
Arm predicted mass (left) 2.0 10.5 16.3 2.5 -4.0 -4.0 -3.8 2.8 -1.4