Hub : Genes

ARL3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.03 0.014 3.6e-04 0.028 0.027 0.013 0.028 0.029 2.3e-04 2.5e-04 7.7e-03 2.3e-04 1.8e-04
2 GTEx Artery Aorta 0.19 0.072 7.9e-04 0.074 NA 0.045 NA 0.056 7.0e-05 NA 1.6e-03 NA 4.8e-04
3 GTEx Brain Cerebellar Hemisphere 0.15 0.073 8.3e-03 0.016 NA 0.107 NA 0.069 1.3e-01 NA 1.1e-03 NA 7.7e-03
4 GTEx Brain Cerebellum 0.20 0.074 2.6e-05 0.092 NA 0.072 NA 0.051 1.1e-03 NA 3.7e-03 NA 1.3e-02
5 GTEx Cells Transformed fibroblasts 0.07 0.033 1.7e-03 -0.002 NA 0.035 NA 0.005 5.0e-01 NA 1.2e-03 NA 1.3e-01
6 GTEx Colon Sigmoid 0.13 0.066 8.1e-03 0.096 NA 0.025 NA 0.054 2.8e-04 NA 4.3e-02 NA 5.5e-03
7 GTEx Esophagus Mucosa 0.14 0.071 8.8e-03 0.042 NA 0.053 NA 0.052 8.3e-04 NA 1.9e-04 NA 2.3e-04
8 GTEx Muscle Skeletal 0.07 0.028 3.5e-04 0.051 NA 0.040 NA 0.063 8.3e-06 NA 8.3e-05 NA 8.9e-07
9 METSIM Adipose 0.04 0.022 3.0e-03 0.000 0.007 -0.001 0.009 -0.002 3.7e-01 2.7e-02 5.7e-01 1.4e-02 8.2e-01
10 ROSMAP Brain Pre-frontal Cortex 0.24 0.063 3.9e-16 0.145 0.157 0.159 0.161 0.158 3.8e-18 1.0e-19 6.0e-20 3.9e-20 7.3e-20
11 YFS Blood 0.39 0.053 0.0e+00 0.135 0.180 0.199 0.176 0.194 8.1e-42 1.9e-56 7.0e-63 3.0e-55 3.4e-61
12 TCGA Breast Tumor 0.38 0.117 3.0e-04 0.030 0.151 0.204 NA 0.141 6.7e-02 2.4e-04 1.8e-05 NA 3.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Alzheimer’s Disease (in mother) 1.7 1.9 5.4 -0.8 -2.3 0.3 -0.3 -1.0 -1.8 -1.7 -1.5 -0.1 -1.8 1.6 -1.3
Alzheimer’s Disease (in father) 0.7 0.8 2.3 -0.6 -0.4 0.4 0.3 -0.8 -0.8 -1.2 -1.5 -0.1 -1.3 0.2 -1.4
Alzheimer’s Disease (including proxy) 1.6 2.2 4.4 -0.7 -2.1 0.4 -0.4 -1.3 -1.9 -2.0 -1.8 -0.4 -2.0 1.6 -1.6
Crohns Disease (2017) 1.3 2.9 9.5 -1.8 0.2 -3.1 -2.2 -0.6 0.4 -0.7 0.5 -2.7 0.6 -2.4 -1.8
Irritable Bowel Disease (IBD) 1.2 2.9 12.3 -2.7 -0.4 -2.3 -1.5 -0.4 -0.7 -1.7 -0.4 -3.5 -0.4 -1.7 -1.2
Ulcerative Colitis (UC) 0.8 1.6 7.8 -2.2 -0.3 -1.0 -0.9 0.6 -0.6 -1.3 -0.2 -2.8 -0.2 -1.1 0.6
Major Depression (MDD) 4.2 5.1 12.4 1.9 3.0 -0.1 -2.3 1.8 2.6 2.0 2.1 2.7 2.0 -1.1 3.5
Reaction Time 3.0 5.8 18.9 -2.5 2.2 -4.4 -3.2 1.9 1.6 0.3 1.3 -2.9 1.3 -3.3 -0.1
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.7 1.2 -0.5 -1.3 -0.9 -1.6 0.1 1.1 1.5 0.4 0.3 0.6 0.7
Breast Cancer 0.6 1.4 6.5 -1.1 0.5 -1.8 -2.6 0.9 0.7 0.3 1.2 -1.1 0.2 -0.8 -0.7
Ovarian Cancer 0.9 1.3 3.8 0.7 -0.5 1.9 1.2 -1.3 -0.7 -0.8 -0.6 1.4 -1.3 1.3 1.0
Prostate Cancer 4.3 6.1 21.8 -4.7 -0.5 -2.8 -2.4 -1.0 -0.8 -2.9 -1.6 -3.4 -0.9 -2.5 -2.7
Age at First Birth 0.8 1.2 5.3 -0.1 -1.3 0.3 -0.4 -2.0 -0.7 -0.1 -0.5 -0.3 -1.3 0.9 -2.3
Bipolar Disorder 6.7 6.6 12.1 1.1 3.3 -1.6 -3.1 1.9 3.5 2.6 2.8 1.5 3.3 -3.2 1.0
Body Mass Index (BMI) (2010) 3.4 4.7 11.2 -1.3 -3.0 1.5 2.8 -2.0 -2.7 -1.9 -2.3 0.2 -3.3 2.0 -0.9
Coronary Artery Disease (CAD) 4.6 5.6 11.0 0.7 3.3 -2.1 -2.8 2.9 2.9 2.0 2.0 0.4 3.0 -2.5 1.7
Crohns Disease (2012) 2.2 3.7 8.7 2.9 -0.2 2.7 2.4 0.6 -0.0 1.4 0.4 3.0 -0.1 2.1 2.6
Mean Putamen Volume 1.6 1.8 3.6 1.6 -1.4 1.5 0.9 -1.4 -1.1 -0.8 -0.9 1.9 -1.3 1.9 -1.0
Fasting Glucose 1.1 1.3 3.5 1.5 -0.4 1.4 1.9 0.2 -0.8 0.8 0.0 1.1 -0.4 1.8 1.4
HbA1C 0.4 0.4 1.4 -0.7 0.7 -0.6 -1.2 0.6 0.5 0.1 -0.1 -0.3 0.5 -1.1 -0.6
HDL Cholesterol 0.5 0.8 3.9 -0.1 0.5 -1.1 -0.9 0.3 0.6 0.3 0.5 -2.0 1.2 -1.2 0.4
LDL Cholesterol 0.3 0.4 0.9 -1.0 -0.7 0.9 0.9 0.0 -0.5 -0.6 -0.7 0.3 -0.5 0.1 -0.7
Lupus 0.7 1.1 4.0 0.2 -1.2 0.7 0.6 -1.7 -0.8 -0.3 -1.1 -0.1 -1.1 0.9 -2.0
Neuroticism 0.6 0.9 4.8 -2.2 0.2 -1.1 -1.2 0.9 -0.4 -1.0 -0.5 -0.3 -0.5 -0.6 0.6
Primary Biliary Cirrhosis 0.6 0.8 2.7 1.6 0.8 0.3 1.2 1.5 1.0 0.9 0.6 0.1 0.9 0.1 0.6
Rheumatoid Arthritis 0.5 0.7 3.2 1.4 0.3 1.1 1.8 0.6 0.4 1.1 -0.0 0.5 -0.0 0.5 -0.1
Schizophrenia 9.1 20.3 30.5 0.3 5.5 -4.6 -5.1 5.4 5.2 3.8 4.9 0.5 5.5 -5.1 4.0
Triglycerides 0.4 0.6 3.7 0.4 0.9 0.7 0.8 -0.2 0.5 0.0 0.5 1.9 0.3 -0.2 0.4
Type 2 Diabetes (T2D) 2.5 2.9 7.3 1.6 1.5 -0.6 -2.5 -0.0 1.9 1.0 2.6 1.1 2.7 -1.2 1.5
Ulcerative Colitis 2.8 4.0 12.0 3.5 1.5 1.4 1.1 0.2 2.0 2.7 1.7 3.4 1.5 0.6 1.7
Blood Eosinophil Count 1.2 9.8 18.9 4.3 3.9 0.4 -1.4 0.6 3.8 3.0 3.2 4.0 4.2 -2.0 3.0
Blood Platelet Count 1.4 16.7 70.3 7.3 1.8 3.9 3.3 -0.6 2.3 3.3 2.3 8.4 1.6 1.1 4.6
Blood Red Count 0.6 6.2 18.1 1.4 4.3 -0.7 -0.9 0.5 3.8 2.3 2.5 1.9 3.4 -3.2 -1.0
Blood White Count 3.1 22.9 52.7 7.2 4.6 2.8 3.0 3.1 4.3 6.1 3.9 6.4 3.0 0.5 7.3
Heel T-Score 0.6 5.0 24.0 1.8 -2.1 1.9 -0.9 -4.5 -0.8 -1.5 -0.5 0.6 1.0 0.1 -4.9
BMI 3.9 23.4 60.1 -3.7 -6.5 2.6 5.5 -3.1 -6.2 -4.2 -5.1 -1.3 -7.8 5.0 -2.8
Height 3.0 59.2 289.0 17.0 -0.5 10.3 8.1 -3.9 0.6 4.3 -2.8 11.6 0.3 8.1 2.7
Waist Hip Ratio (WHR) 1.0 4.7 24.9 5.0 1.0 3.6 -0.0 0.2 1.3 1.4 0.7 2.4 2.1 1.0 1.4
Systolic Blood Pressure 5.9 30.1 68.2 1.3 8.3 -3.1 -5.6 8.0 6.6 4.1 5.3 0.4 6.0 -4.3 6.5
Smoking Status 8.7 21.1 70.6 4.7 -1.5 6.2 8.4 -0.6 -1.5 2.5 -0.8 7.1 -2.2 5.3 5.2
Allergy or Eczema 6.0 15.7 64.9 -8.1 -2.6 -5.0 -2.7 -1.2 -2.1 -4.0 -0.8 -5.0 -1.8 -3.0 -5.0
Cardiovascular Disease 4.5 14.8 31.1 3.9 5.2 -1.0 -1.8 5.0 4.4 4.2 3.9 3.4 3.3 -1.3 5.6
Hypothyroidism (self reported) 0.2 0.4 1.2 1.0 0.3 1.0 -0.2 -0.7 0.1 -0.1 -0.3 1.1 0.0 0.7 0.2
Respiratory disease 0.8 1.8 7.4 -2.7 -1.3 -0.2 -1.3 -0.8 -0.9 -2.0 -0.8 -1.1 -0.7 -0.6 -1.6
Type 2 Diabetes (T2D) 2.8 5.3 13.5 2.7 -2.0 3.0 3.7 -1.2 -1.7 0.0 -1.1 2.3 -1.8 3.5 1.7
Lung FEV1/FVC ratio 0.4 1.9 15.3 -0.7 -0.6 0.7 3.9 -0.2 -0.7 0.5 -1.1 -1.1 -1.5 0.3 -0.3
Lung FVC 0.7 3.7 12.4 -2.0 1.9 -2.4 -0.2 3.3 1.1 0.7 -0.5 -3.5 0.8 -2.1 0.8
Neuroticism 2.0 4.8 14.3 -2.5 2.1 -2.0 -3.8 2.3 1.3 -0.1 1.4 -3.0 2.3 -2.4 0.7
Chronotype (morning person) 1.2 2.9 18.1 -1.5 -1.0 -0.6 -0.2 -1.5 -1.1 -0.9 -1.0 -1.7 -1.9 1.0 -4.2
Hair Pigment 0.1 1.6 4.1 0.1 2.0 0.1 -0.8 1.5 1.6 0.7 0.9 0.0 1.3 -1.6 2.0
Tanning 0.2 2.2 6.1 2.2 -0.7 2.2 2.5 -2.3 -0.4 1.0 -0.3 0.8 -0.5 1.0 1.3
Hand grip strength (left) 6.1 16.3 53.0 -3.8 3.3 -6.4 -7.3 2.5 3.0 1.0 4.1 -2.9 2.7 -5.1 1.0
Number of treatments/medications taken 1.6 2.8 10.4 -0.9 -2.0 -0.3 0.4 -2.0 -2.1 -1.3 -1.3 -3.2 -1.3 1.9 -1.1
Average weekly spirits intake 0.6 0.8 2.4 -1.1 -0.3 -1.6 -0.7 -0.6 -0.8 -0.8 -0.1 -0.9 -0.6 0.7 -1.3
Sensitivity / hurt feelings 0.3 0.5 2.3 0.7 -0.1 -0.4 0.9 0.3 0.5 1.5 0.3 0.9 -0.7 0.3 -0.7
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.4 -0.8 -1.1 0.4 1.2 0.2 -0.9 -0.3 0.1 0.6 -1.1 0.8 0.2
Hearing difficulty/problems: Yes 1.9 2.8 12.2 -3.0 0.3 -1.1 -1.0 0.3 -0.2 -1.6 -0.4 -3.5 -0.1 -1.6 -2.3
Relative age of first facial hair 0.9 1.9 5.3 -2.1 -1.3 -1.3 -0.1 0.7 -1.6 -1.6 -1.1 -1.1 -1.1 0.4 -2.3
Other serious medical condition/disability diagnosed by doctor 1.6 2.0 5.1 -0.5 -2.3 1.1 0.8 -1.1 -2.1 -1.3 -1.4 -0.5 -1.7 2.1 -0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.3 0.8 -0.0 -0.4 1.0 0.4 0.1 1.1 0.4 -0.5 0.3 0.4 1.0
Ever had hysterectomy (womb removed) 1.5 1.7 6.8 2.2 0.5 0.5 1.2 0.6 0.7 1.6 0.9 1.4 0.7 0.4 2.6
Systolic blood pressure, automated reading 5.1 15.2 42.7 -0.2 -5.2 3.0 3.7 -6.5 -4.2 -3.0 -3.8 -0.7 -3.4 2.9 -5.4
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 10.6 -1.9 -0.1 -2.9 -3.3 0.5 0.0 -1.0 -0.0 -1.6 -0.3 -1.1 -1.4
Angina 1.1 1.5 2.9 -1.6 -1.4 0.1 -0.4 -1.6 -1.1 -1.1 -0.8 -1.7 -1.0 0.1 -1.7
Medication for hormone replacement therapy 2.5 2.7 6.7 -1.2 -1.8 0.6 1.2 -0.4 -2.5 -1.7 -1.8 -0.9 -2.4 2.6 0.6
Vitamin and mineral supplements 1.3 1.8 8.0 0.3 -0.7 2.1 2.8 -0.1 -0.5 0.1 -1.0 1.9 -1.6 0.9 -0.3
Supplements: Zinc 2.8 3.0 8.2 -1.2 1.4 -1.9 -2.9 0.4 1.4 0.8 1.6 -2.5 2.1 -2.2 -0.4
Medication: Co-codamol 2.5 2.9 8.6 0.0 -1.9 1.7 1.3 -2.9 -1.9 -1.7 -1.6 -0.3 -1.6 1.8 -1.6
Medication: Metformin 2.1 2.9 10.0 -0.7 2.0 -2.2 -3.2 1.1 1.9 0.9 1.1 -0.6 1.5 -2.2 0.8
Diabetes (father) 1.4 1.8 5.8 -0.2 1.1 -2.4 -2.1 -0.1 1.3 0.5 0.8 -1.2 0.9 -2.0 -0.9
Diabetes (mother) 1.2 1.5 5.6 -2.3 -0.0 -2.4 -1.2 1.1 -0.2 -0.3 -0.5 -1.8 -0.8 -0.6 -0.8
Severe depression (siblings) 2.2 2.5 6.4 0.5 -2.1 1.0 2.0 -1.0 -2.0 -0.8 -1.6 -0.2 -1.6 2.5 -1.7
Pack years adult smoking proportion 2.8 4.2 12.9 -2.4 -1.3 -1.5 -2.4 -0.3 -1.7 -2.9 -1.9 -2.3 -1.0 0.7 -3.6
Impedance of leg (right) 3.7 18.4 43.7 -4.2 -6.6 1.6 3.8 -2.3 -5.6 -4.1 -4.0 -0.5 -6.4 4.2 -3.8
Leg fat-free mass (left) 3.0 16.4 41.2 -2.2 4.8 -4.8 -6.4 3.2 3.7 1.3 3.6 -3.5 4.9 -5.3 1.2
Trunk fat percentage 1.3 5.3 13.8 0.8 2.3 -2.0 -3.7 2.5 2.5 1.7 1.7 -1.9 3.6 -2.3 -0.7
Hand grip strength (right) 4.0 10.9 39.5 -3.2 2.9 -5.0 -6.3 1.4 2.4 0.6 3.6 -1.9 2.2 -4.0 1.0
Townsend deprivation index at recruitment 1.6 2.3 8.9 -1.7 0.6 -2.0 -3.0 0.9 0.4 -0.6 -0.3 -2.6 0.4 -0.9 -1.4
Current tobacco smoking 4.3 7.1 26.1 -3.4 0.4 -3.1 -5.1 0.1 0.3 -2.0 0.1 -3.8 0.8 -2.3 -3.6
Average weekly fortified wine intake 0.3 0.3 1.4 0.4 0.6 0.5 0.7 0.1 0.4 1.2 0.5 0.1 0.1 0.3 0.7
Maternal smoking around birth 4.6 6.7 25.4 -2.4 1.5 -3.5 -5.0 0.4 1.0 -1.0 0.7 -4.0 1.8 -2.5 -2.4
Fed-up feelings 0.1 0.2 0.6 0.8 0.7 -0.5 -0.5 0.1 0.6 0.6 0.7 0.3 0.0 0.0 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.3 -0.5 0.1 -0.4 -0.6 0.4 0.5 0.2 1.1 0.5 0.5 -0.6 -0.0
Relative age voice broke 0.9 1.3 5.8 -1.3 -1.1 -0.7 -0.0 -0.4 -1.0 -1.5 -0.8 -1.5 -0.6 -0.3 -2.4
Taking other prescription medications 1.2 1.9 5.2 -0.4 -1.8 0.2 0.7 -1.0 -1.7 -1.2 -1.9 -2.3 -1.2 1.5 -1.0
Age when periods started (menarche) 0.6 1.5 5.1 -1.2 0.5 -2.0 -1.8 0.9 0.1 -0.6 -0.9 -2.3 0.0 -0.8 -0.8
Bilateral oophorectomy (both ovaries removed) 2.6 2.9 5.9 2.4 -1.9 2.4 2.4 -2.0 -1.2 -0.1 -0.1 1.2 -0.4 2.3 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 7.5 -2.0 -0.8 -0.2 0.8 0.4 -1.6 -1.2 -1.3 -0.4 -2.7 1.6 0.4
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.7 1.0 1.2 -0.3 0.5 0.9 1.2 1.4 1.0 -1.0 1.6 -0.7 0.2
Qualifications: CSEs or equivalent 0.8 1.1 3.7 -0.2 1.1 -1.0 -1.9 1.0 1.1 0.9 1.3 -0.9 0.9 -1.1 0.2
Serious illness, injury or assault to yourself 0.4 0.5 3.2 0.8 -0.4 0.1 0.3 -0.9 0.2 0.6 0.1 0.3 0.3 0.2 -1.8
High blood pressure 3.9 11.2 29.1 -3.1 -4.2 0.6 1.5 -4.7 -3.3 -3.6 -3.1 -3.8 -2.5 0.6 -5.4
Hayfever, allergic rhinitis or eczema 4.9 10.5 42.5 6.5 1.5 4.4 2.6 1.2 1.1 3.1 0.3 4.5 1.1 3.0 3.6
Multivitamins +/- minerals 0.4 0.5 1.6 0.4 0.4 -1.0 -1.1 0.2 0.4 0.3 0.6 -0.7 1.3 -0.2 0.6
Stomach or abdominal pain in last month 1.5 1.9 4.0 0.3 1.7 -0.7 -1.6 1.3 1.7 1.9 2.0 -0.9 1.4 -1.0 0.8
Supplements: Glucosamine 0.9 1.2 6.8 -0.3 0.9 -1.4 -0.9 0.1 0.5 0.0 0.1 -2.6 1.4 -1.1 0.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.1 1.0 -0.0 1.5 1.5 -0.3 -0.3 0.4 -0.1 0.6 -0.7 1.4 0.6
Medication: Atenolol 4.1 5.1 9.1 -2.8 -2.8 0.7 0.4 -3.0 -2.5 -3.0 -2.4 -1.6 -2.6 0.8 -2.2
Medication: Levothyroxine sodium 0.5 0.8 2.1 0.9 -1.4 1.4 1.1 -0.5 -0.9 -0.4 -0.4 0.6 -0.7 1.1 0.2
Sitting height 2.4 17.3 86.9 -9.3 -2.2 -4.6 -2.7 -0.1 -2.3 -3.9 -0.4 -6.9 -1.1 -3.4 -2.5
Chronic bronchitis/emphysema (father) 0.5 0.6 3.0 0.6 0.0 -1.5 -0.0 -0.4 0.0 0.1 0.0 -1.0 -0.4 0.6 -1.7
High blood pressure (mother) 2.8 4.0 11.9 0.9 -2.3 2.8 2.4 -3.5 -1.7 -1.1 -2.1 1.3 -1.3 1.1 -1.7
Body mass index (BMI) 2.6 11.2 28.9 2.9 4.3 -2.3 -4.8 2.0 4.1 2.7 3.1 -0.4 5.4 -3.2 0.8
Impedance of leg (left) 3.3 16.4 39.7 -4.1 -6.3 1.6 3.7 -2.3 -5.3 -4.0 -3.9 -0.6 -5.8 3.5 -3.6
Leg predicted mass (left) 2.9 15.7 39.9 -2.2 4.6 -4.7 -6.3 3.1 3.6 1.2 3.5 -3.5 4.8 -5.2 1.1
Trunk fat mass 2.4 10.5 29.4 -0.8 3.2 -3.7 -5.4 3.0 3.2 1.5 2.6 -3.1 4.3 -3.9 -0.5
Waist circumference 2.4 9.0 26.1 -1.3 2.7 -4.5 -5.1 2.3 2.5 0.8 2.3 -2.9 3.6 -3.6 -0.8
Number of incorrect matches in round 2.1 3.6 9.1 1.7 -1.6 2.1 3.0 -1.4 -1.7 0.5 -0.9 1.4 -1.6 3.0 2.0
Past tobacco smoking 9.2 17.3 47.3 5.1 -0.2 5.8 6.8 -0.2 -0.7 2.1 -0.4 6.9 -1.1 4.3 5.4
Alcohol usually taken with meals 1.5 2.4 10.3 1.3 -0.3 2.0 2.5 0.2 0.0 0.9 0.2 3.2 -0.5 1.1 1.9
Nervous feelings 4.1 7.7 24.0 1.0 -2.9 2.5 4.9 -2.5 -2.4 -0.7 -1.8 3.4 -3.6 3.4 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.8 0.9 -1.3 2.0 1.7 -1.1 -0.7 -0.1 0.4 2.2 -0.4 1.2 0.2
Hearing difficulty/problems with background noise 3.7 5.9 21.5 -4.6 -1.0 -2.2 -2.1 0.6 -1.2 -2.8 -1.5 -3.8 -1.3 -1.1 -3.1
Hair/balding pattern: Pattern 2 2.3 2.9 5.7 1.2 2.3 -1.5 -0.4 1.6 2.0 2.4 2.1 0.5 1.8 -0.9 2.2
Had menopause 0.6 0.8 2.6 1.6 -0.7 1.6 1.0 -0.4 -0.5 0.0 -0.3 0.3 -0.6 1.5 -0.1
Had other major operations 0.8 0.9 3.2 0.9 0.6 0.4 0.5 0.7 1.3 1.8 1.4 -0.5 1.3 -0.6 0.3
Forced vital capacity (FVC) 1.2 4.6 23.8 -4.9 -2.0 -1.5 -1.9 -1.6 -2.2 -2.9 -0.2 -1.4 -1.4 -0.5 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 5.4 -2.3 -0.2 -1.0 0.5 1.1 -1.0 -0.6 -0.9 -1.1 -2.2 0.9 0.7
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 -0.5 -0.7 -0.1 0.7 -0.4 -0.9 -1.0 -1.1 -0.5 -0.5 0.1 -1.1
Qualifications: None of the above 1.0 2.1 6.6 0.3 0.6 -2.4 -2.6 -0.9 1.1 0.3 2.0 -0.3 1.7 -1.7 -0.4
Financial difficulties in last 2 years 0.8 1.1 2.6 -1.6 0.3 -1.1 -1.5 -0.4 0.2 -0.8 0.4 -0.7 0.4 -1.5 -1.6
Mouth/teeth dental problems 1.2 1.8 4.4 0.2 -1.4 1.6 2.0 -0.3 -1.2 -0.3 -0.4 2.1 -1.7 1.9 0.3
Heart attack 2.9 3.7 12.7 -0.8 -2.6 2.0 0.7 -3.6 -2.3 -1.9 -1.2 -0.7 -1.8 1.9 -1.6
Allergy 3.4 7.6 33.7 -5.8 -1.7 -3.1 -2.1 -1.3 -1.2 -3.1 -0.7 -3.4 -1.0 -2.7 -2.8
Pain all over the body in last month 1.2 1.3 5.4 0.8 -1.2 1.1 0.5 -2.3 -1.3 -1.4 -1.0 0.1 -0.8 1.2 -0.2
Diabetes (self-reported) 3.0 4.7 13.6 -1.9 2.1 -3.1 -3.7 1.8 1.7 0.4 1.2 -2.0 1.7 -3.2 -0.8
Hayfever/allergic rhinitis (self-reported) 1.6 2.2 6.8 2.6 1.0 1.7 1.8 0.6 0.3 1.0 -0.5 2.5 -0.3 1.6 1.2
Medication: Ramipril 1.1 1.4 4.0 0.0 -1.6 1.3 2.0 -1.2 -1.1 -0.1 -0.8 -1.0 -1.3 1.2 -1.2
Medication: Simvastatin 1.4 2.0 4.8 -0.6 1.8 -0.3 -2.2 0.3 1.7 1.3 1.6 -1.5 1.8 -1.5 -0.7
Fluid intelligence score 0.5 1.0 3.3 -1.4 0.8 1.1 1.1 1.8 0.1 -0.7 -1.2 0.9 -1.0 -0.2 0.6
Illnesses of siblings 1.3 1.8 10.2 1.7 0.5 0.9 1.3 0.9 0.3 0.3 -0.6 3.2 -0.6 0.8 1.8
Neuroticism score 1.4 3.0 8.8 2.0 -1.3 1.8 3.0 -1.9 -0.9 0.1 -0.9 2.2 -2.0 1.9 -0.8
Weight 2.8 14.0 42.4 -2.4 3.6 -4.9 -6.5 2.8 3.0 0.6 2.9 -3.8 4.5 -4.8 -0.2
Impedance of arm (right) 2.2 10.2 19.6 -1.5 -4.4 3.2 4.4 -1.1 -3.8 -2.5 -3.9 0.3 -4.3 3.8 -1.5
Arm fat percentage (right) 1.6 6.4 16.9 2.1 3.0 -1.6 -4.0 2.0 3.2 2.0 2.0 -0.8 4.1 -2.4 -0.0
Trunk fat-free mass 2.9 17.1 42.2 -4.8 3.5 -6.0 -6.5 2.6 2.5 -0.2 3.5 -4.5 3.5 -5.8 0.4
Hip circumference 2.4 10.6 33.3 -0.3 3.5 -3.6 -5.8 2.9 3.1 1.2 2.8 -2.4 4.6 -3.8 -0.1
Time employed in main current job 1.5 1.7 2.6 1.1 1.4 0.2 1.0 0.9 1.5 1.5 1.4 1.3 1.5 -1.5 1.6
Alcohol intake versus 10 years previously 0.5 0.7 2.2 -0.4 0.1 -1.1 -0.8 -0.9 0.1 -1.1 0.5 -1.0 1.5 -1.1 -0.2
Father’s age at death 0.2 0.3 0.6 -0.7 0.7 -0.1 0.5 0.2 0.6 0.3 0.3 0.6 -0.2 -0.8 0.7
Worrier / anxious feelings 5.7 10.8 44.5 3.4 -2.4 4.8 6.7 -2.4 -2.0 0.6 -2.1 3.3 -2.4 3.5 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 5.1 -1.7 -0.1 -1.0 -2.3 0.7 -0.1 -0.9 0.4 -1.6 0.1 -0.8 -0.8
Falls in the last year 2.1 2.9 7.7 -1.7 -1.3 0.4 -0.3 -2.8 -1.6 -2.4 -1.9 -2.6 -0.8 0.3 -1.8
Hair/balding pattern: Pattern 3 1.4 2.2 6.7 -2.0 -2.1 0.2 -0.2 -1.0 -1.6 -1.6 -0.8 -2.6 -1.1 0.3 -1.6
Number of live births 0.4 0.5 2.8 -0.1 -0.8 0.1 0.7 -0.0 -0.4 0.4 0.4 -0.8 -0.5 0.9 -1.7
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 12.6 -3.5 -1.6 -1.3 -2.6 -1.3 -1.5 -2.1 0.5 -0.2 -0.9 -0.4 -0.3
Pulse rate 1.1 1.9 4.4 2.1 -1.0 1.6 1.6 -1.3 -1.0 -0.5 -1.7 0.9 -1.0 1.7 -1.1
Happiness 0.9 1.1 2.3 1.3 1.1 -0.2 0.7 0.9 1.1 1.5 1.3 0.2 1.1 -0.4 1.4
Noisy workplace 0.3 0.3 1.1 0.2 -0.0 -0.5 -0.8 -0.7 -0.4 -0.4 -0.6 -1.1 -0.1 0.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.9 2.1 10.0 -3.2 -1.1 0.2 1.8 0.9 -1.3 -1.3 -1.8 -0.2 -1.6 0.2 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.5 -0.4 -0.8 -0.3 0.4 -0.9 -1.2 -0.9 -1.1 -0.2 -0.8 0.6 0.2
Mouth/teeth dental problems: Dentures 1.9 3.3 8.1 -0.5 1.9 -2.4 -2.8 1.4 1.8 0.6 1.3 -1.9 2.0 -2.5 -0.5
Asthma 1.1 2.1 6.3 2.5 1.6 -0.6 -0.3 0.9 1.7 2.2 1.8 0.5 1.9 -0.5 -0.0
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 3.7 1.9 0.4 0.4 0.8 0.5 -0.2 0.9 0.6 1.5 0.5 1.7 1.9
Medication: Cholesterol lowering 0.5 0.7 1.5 -0.1 0.6 0.3 -1.2 -0.9 0.9 0.6 0.4 -0.9 1.2 -0.9 -1.2
Depression (self-reported) 0.4 0.5 1.5 0.6 0.0 -0.4 -1.2 0.4 0.6 1.0 1.2 -0.4 0.7 -0.0 0.5
Medication: Lansoprazole 0.6 0.7 1.6 0.8 -0.8 0.7 0.9 -1.3 -0.9 -0.5 -1.0 -1.0 -0.1 1.0 -0.4
Prospective memory result 0.4 0.5 1.4 -0.1 0.6 -1.1 -0.4 -0.1 0.8 0.6 0.9 -0.3 0.9 -1.2 -0.4
Lung cancer (father) 1.1 1.3 5.7 -0.8 1.1 -1.0 -0.1 2.4 0.7 0.4 0.4 -1.8 0.9 -1.2 1.1
Illnesses of mother 0.6 0.7 1.5 0.6 1.0 -0.9 -0.8 1.1 0.9 0.5 0.9 -0.5 1.2 -0.4 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 7.7 -2.8 -1.5 -0.2 -1.4 -1.5 -1.6 -2.3 0.0 0.7 -1.1 -0.1 0.4
Pulse wave Arterial Stiffness index 0.9 1.0 4.2 2.1 -0.9 1.1 1.3 -1.0 -0.6 0.8 -0.3 -0.3 -0.1 1.4 0.7
Impedance of arm (left) 2.8 13.3 25.0 -1.4 -4.9 3.9 5.0 -1.6 -4.3 -2.7 -4.3 0.2 -4.8 4.5 -1.7
Arm fat mass (right) 2.1 8.9 24.1 0.7 3.5 -2.8 -4.9 2.5 3.3 1.8 2.7 -1.8 4.5 -3.4 0.1
Trunk predicted mass 2.9 16.8 41.7 -4.7 3.5 -5.9 -6.5 2.5 2.5 -0.2 3.5 -4.4 3.5 -5.7 0.4
Standing height 2.5 25.7 139.2 -11.8 -0.8 -6.3 -4.5 2.4 -1.9 -4.2 0.1 -7.6 -1.3 -4.1 -1.8
Length of working week for main job 2.8 3.1 11.3 -3.4 -1.2 -2.1 -1.2 0.1 -1.7 -1.8 -1.3 -1.7 -1.7 0.0 -2.2
Exposure to tobacco smoke at home 1.8 2.0 6.3 -0.3 -0.6 1.2 0.0 -1.7 -1.2 -1.9 -2.2 -1.3 -0.7 0.4 -2.5
Breastfed as a baby 1.3 1.6 3.5 0.7 -1.6 0.5 1.9 -1.2 -1.2 -0.9 -1.3 1.1 -1.7 1.4 -0.4
Tense / ‘highly strung’ 0.8 1.4 6.0 0.8 -1.6 0.6 1.1 -2.5 -0.7 -0.6 -0.2 1.0 -0.7 0.7 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 6.2 -1.3 -1.3 -0.9 0.1 -0.3 -1.2 -0.2 -0.8 -2.5 -1.0 0.7 -1.7
Hair/balding pattern: Pattern 4 0.1 0.4 1.1 0.5 0.9 0.0 0.1 -0.3 0.9 -0.3 0.2 0.6 0.2 -1.0 0.8
Birth weight of first child 1.5 2.8 9.6 -0.6 2.4 -0.8 -1.8 1.7 1.9 0.0 1.3 -0.5 2.3 -3.1 0.3
Peak expiratory flow (PEF) 1.6 3.8 16.0 -3.3 0.6 -3.0 -4.0 0.0 0.2 -1.5 0.8 -1.0 0.6 -2.3 0.4
Pulse wave reflection index 3.8 4.6 10.4 -0.5 2.0 -2.6 -2.1 2.8 1.7 1.8 2.1 -1.1 2.4 -2.1 3.2
Ever highly irritable/argumentative for 2 days 2.2 2.7 4.4 -1.9 -2.0 -0.5 -0.2 -0.7 -2.0 -1.8 -2.0 -1.6 -2.1 0.6 -2.0
Loud music exposure frequency 0.4 0.5 1.6 -1.3 -0.2 -0.7 -0.9 -1.2 -0.3 -0.7 0.2 -0.3 -0.5 -0.4 -0.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.5 -1.2 -0.3 0.9 1.6 -1.0 -0.7 -1.1 -1.1 -0.4 -0.7 -0.2 -0.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 1.2 -0.2 -0.1 0.1 -0.4 -0.9 -0.3 -1.1 -0.2 -0.3 0.6 -0.1 0.1
Blood clot in the leg (DVT) 0.5 0.7 1.9 1.0 -0.3 0.8 1.2 -0.7 -0.3 0.2 -0.5 1.4 -0.6 1.1 0.7
Medication: Paracetamol 1.1 1.8 5.9 0.0 -1.9 0.1 0.6 -0.9 -2.0 -0.5 -0.7 -1.9 -1.4 2.4 -0.6
Headache pain in last month 1.3 2.2 7.7 2.0 1.1 0.7 -0.3 1.2 1.2 1.6 2.0 1.0 1.7 -0.3 2.8
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 5.0 0.8 0.7 -0.3 0.2 2.2 0.4 0.7 0.9 2.1 -0.2 0.6 2.2
Glaucoma (self-reported) 0.3 0.3 2.3 0.1 -0.4 -0.2 -0.2 -0.8 0.1 -0.1 -0.1 -0.2 -0.5 -0.1 -1.5
Gout (self-reported) 0.1 0.2 0.6 -0.7 -0.4 -0.2 0.2 0.6 -0.1 0.2 0.1 -0.8 -0.1 -0.1 -0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.9 -0.5 -2.0 1.0 1.5 -0.4 -1.7 -1.0 -0.9 -0.6 -1.4 1.3 -0.2
Medication: Amlodipine 1.5 2.1 5.5 0.6 -1.4 2.0 1.6 -2.0 -1.2 -1.1 -2.4 0.2 -0.9 0.8 -1.6
Medication: Ventolin 100micrograms inhaler 0.4 0.6 2.0 0.5 0.8 -0.6 -0.2 0.5 0.9 1.4 1.0 0.4 0.6 -0.6 -0.6
Birth weight 2.4 5.2 10.7 -0.9 2.8 -1.1 -2.3 2.7 2.4 0.7 2.2 -1.9 2.3 -3.3 3.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.0 -1.4 -0.2 -1.3 0.0 0.7 -0.2 -0.6 0.1 -0.8 -0.2 -0.7 0.2
High blood pressure (siblings) 1.0 1.4 6.9 -1.7 -1.0 -0.4 0.2 -1.1 -0.9 -0.8 0.1 -2.6 -0.2 -0.6 -1.7
Forced vital capacity (FVC), Best measure 0.9 3.3 15.4 -3.9 -1.8 -0.5 -0.8 -1.9 -2.1 -3.0 -0.2 -0.2 -1.7 -0.1 -0.1
Body fat percentage 1.2 4.9 15.5 1.0 2.1 -2.1 -3.9 2.1 2.4 1.3 1.5 -1.6 3.4 -2.1 -1.0
Leg fat percentage (right) 1.4 5.1 17.3 1.0 2.0 -2.5 -4.2 1.8 2.4 1.3 2.1 -1.1 3.4 -2.0 -1.0
Arm fat-free mass (right) 3.1 16.3 44.5 -3.9 3.6 -5.7 -6.7 2.4 2.7 0.3 3.6 -4.4 4.0 -5.4 0.0
Exposure to tobacco smoke outside home 2.3 3.1 9.9 -2.8 0.6 -2.6 -3.1 0.4 0.2 -1.4 0.1 -2.2 0.1 -1.7 -1.6
Comparative body size at age 10 0.6 1.8 4.9 -0.2 1.4 -1.4 -2.0 -0.8 1.2 -0.8 -0.2 -0.7 1.3 -1.9 -2.2
Number of full brothers 0.6 0.7 1.6 -0.7 -1.0 -0.4 -1.2 -1.1 -0.6 -1.1 -0.5 -0.9 -0.2 0.2 -1.3
Worry too long after embarrassment 1.1 1.9 6.2 1.4 -0.8 1.2 2.5 -1.9 -0.6 0.3 -0.9 1.9 -0.9 1.3 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.5 0.5 -1.7 0.7 1.6 -1.9 -1.2 -0.4 -0.4 0.0 -0.8 1.2 -1.0
Wheeze or whistling in the chest in last year 0.9 1.6 4.1 0.5 1.7 -0.8 -1.3 -0.0 1.3 1.0 1.0 -1.7 2.0 -1.6 -0.1
Number of children fathered 0.1 0.1 0.3 -0.5 -0.1 -0.4 -0.3 0.5 -0.1 0.4 -0.0 -0.5 0.1 0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 8.1 -2.9 -1.4 -0.6 0.0 -0.6 -1.2 -1.5 -0.7 -1.5 -1.6 -0.4 -2.3
Age at first live birth 1.3 2.3 4.2 1.3 1.8 0.2 1.2 1.0 2.0 1.7 1.2 1.6 1.7 -1.7 1.9
Pulse wave peak to peak time 1.4 1.7 8.0 -2.8 1.0 -1.6 -1.6 1.3 0.6 -0.9 0.3 -0.2 -0.0 -1.6 -0.8
Health satisfaction 0.4 0.5 1.9 -0.3 0.4 -1.4 -0.5 1.0 0.2 0.0 -0.1 -0.7 0.9 -0.9 -0.8
Shortness of breath walking on level ground 0.3 0.3 1.2 1.1 0.7 0.3 -0.5 -0.3 0.6 0.6 0.2 -0.2 0.7 -0.3 0.3
Qualifications: College or University degree 2.0 6.3 18.7 -1.1 -2.5 3.3 4.3 -0.4 -2.6 -1.3 -3.2 0.5 -3.1 3.0 -0.5
Eye problems/disorders: None of the above 1.1 1.2 5.8 1.5 0.9 0.8 -0.5 0.9 0.7 0.8 0.0 0.8 1.6 0.1 2.4
Mouth/teeth dental problems: Loose teeth 4.2 5.0 10.0 -0.3 2.3 -2.6 -3.2 1.2 2.7 2.0 3.1 -1.5 2.4 -2.6 -0.6
Emphysema/chronic bronchitis 0.5 0.5 1.6 -0.7 0.5 -1.0 -1.3 0.1 0.1 -0.3 0.1 -1.1 -0.2 -0.2 -1.3
Medication for pain relief, constipation, heartburn 2.0 3.5 11.2 0.2 2.2 -1.7 -1.5 1.8 2.7 1.4 1.6 1.1 2.1 -3.4 -0.1
Neck or shoulder pain in last month 1.2 1.7 6.6 -0.1 -2.2 0.3 -0.8 -0.7 -1.6 -1.1 -0.7 -1.0 -0.9 1.5 -2.6
Medication: Blood pressure 2.0 3.5 7.1 -1.2 -2.2 1.2 1.3 -2.5 -1.8 -1.8 -2.3 -2.4 -1.3 0.5 -2.7
Angina (self-reported) 1.7 2.2 4.6 -1.6 -1.9 0.3 -0.1 -2.0 -1.5 -1.3 -1.1 -2.0 -1.3 0.5 -2.1
Migraine (self-reported) 6.0 7.4 17.7 1.4 3.3 -2.1 -1.6 3.3 3.0 2.8 2.9 0.9 3.2 -2.0 4.2
Medication: Ibuprofen 0.6 0.7 1.8 1.0 0.3 -0.0 0.3 1.0 -0.1 0.9 0.9 1.4 0.4 1.1 1.3
Medication: Allopurinol 0.5 0.6 2.2 -1.5 -0.6 -0.3 0.6 -0.1 -0.8 -0.9 -0.5 -0.7 -0.8 0.0 -1.3
Medication: Omeprazole 0.9 1.0 2.4 -1.2 -0.8 -0.2 0.0 -0.6 -1.1 -0.7 -1.2 -1.6 -1.4 0.9 -1.2
Medication: Seretide 50 evohaler 0.3 0.4 1.2 -0.3 0.7 -0.2 -0.6 0.7 0.6 0.3 -0.1 -0.6 0.5 -1.1 -0.7
Mean time to correctly identify matches 1.7 3.4 8.6 1.0 -2.3 2.9 2.4 -2.1 -1.8 -1.2 -1.1 0.9 -1.4 2.4 -0.9
Heart disease (mother) 1.6 2.0 3.9 -0.5 -1.6 1.1 1.3 -1.2 -1.6 -0.7 -1.5 -1.1 -2.0 1.8 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 3.7 -0.8 -0.4 -0.8 -1.3 0.4 0.0 -0.3 -0.5 0.0 0.1 -0.7 -1.9
Whole body fat mass 2.2 9.5 29.6 -0.5 3.1 -3.5 -5.4 2.6 3.0 1.3 2.5 -2.8 4.2 -3.5 -0.6
Leg fat mass (right) 2.5 10.0 33.8 -0.5 3.1 -3.8 -5.8 2.6 2.9 1.2 2.6 -2.7 4.2 -3.6 -0.7
Arm predicted mass (right) 3.1 16.3 43.0 -3.9 3.6 -5.7 -6.6 2.6 2.8 0.4 3.7 -4.2 4.0 -5.5 -0.2
Pulse rate, automated reading 0.5 1.5 2.8 1.3 -1.5 0.9 1.4 0.1 -1.1 -0.4 -1.4 1.1 -1.4 1.7 -1.4
Alcohol intake frequency. 0.7 1.7 6.4 -1.8 -0.0 -1.9 -2.5 -0.1 0.1 -1.1 1.1 -1.2 0.9 -1.5 -0.2
Comparative height size at age 10 2.1 12.0 51.1 -7.2 0.6 -5.1 -3.7 2.3 -0.0 -1.4 1.5 -5.5 -0.1 -3.7 -0.2
Number of full sisters 0.4 0.5 1.7 0.1 1.0 -1.1 -0.7 1.3 0.7 0.6 0.4 -0.0 0.3 -0.6 -0.4
Suffer from ‘nerves’ 4.0 6.4 11.4 0.1 -3.4 1.9 3.2 -3.1 -2.9 -2.2 -2.1 1.0 -3.2 2.8 -2.1
Overall health rating 0.5 1.0 3.6 0.9 0.3 -1.1 -1.9 0.9 0.7 0.4 0.7 -0.5 1.8 -0.9 -0.7
Chest pain or discomfort 0.3 0.5 2.8 0.1 -0.2 -0.3 -1.7 -0.4 -0.1 -0.4 -0.1 -1.5 0.5 -0.2 -0.2
Had major operations 0.4 0.5 2.3 0.2 0.5 -1.5 -1.1 1.0 0.5 0.1 0.4 -0.3 0.7 -0.6 -0.1
Age at last live birth 1.1 1.6 3.8 0.5 1.5 -0.9 0.0 1.1 1.9 1.7 1.4 -0.0 1.8 -1.6 0.6
Family relationship satisfaction 0.3 0.3 1.3 -0.4 -0.3 0.3 0.6 0.1 0.5 0.0 0.2 -0.2 0.8 -1.1 -1.1
Leg pain on walking 0.4 0.5 3.1 0.5 -0.5 0.7 -0.4 -1.1 -0.4 -0.6 -0.5 -0.6 0.1 0.1 -1.7
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 6.1 -0.7 -0.6 -1.0 -2.5 -0.6 -0.0 0.1 0.1 -2.3 0.1 -0.3 -2.2
Commuting to job workplace: Car/motor vehicle 1.2 1.4 5.0 0.6 1.5 -1.0 -2.2 0.8 1.2 0.6 0.9 0.3 1.5 -1.2 1.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 3.8 1.7 1.4 0.7 -0.3 1.9 1.6 1.8 1.0 0.7 1.1 -0.2 0.9
Medication: Aspirin 1.7 2.2 4.4 -1.6 -1.9 0.9 0.3 -1.8 -1.6 -1.6 -1.3 -2.1 -1.4 0.5 -1.6
Supplements: Vitamin C 2.5 3.0 8.3 -0.3 1.4 -1.7 -2.9 -0.2 1.5 0.9 2.0 -2.6 2.3 -1.9 -0.4
Knee pain experienced in last month 1.9 3.0 13.9 -0.0 1.1 -1.6 -3.2 -0.2 1.0 0.1 0.7 -3.7 1.7 -1.3 -1.0
Hypertension (Self-reported) 3.6 10.0 25.3 -2.6 -4.0 0.8 1.7 -4.5 -3.2 -3.4 -3.0 -3.4 -2.4 0.8 -5.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 6.6 -1.1 -1.1 0.4 0.4 -2.3 -1.4 -1.8 -1.0 -2.6 -0.7 0.4 -0.7
Illnesses of father: Heart disease 1.6 2.2 7.0 -2.0 -2.1 0.7 0.4 -2.6 -1.8 -1.5 -0.5 -1.5 -1.2 0.6 -0.8
Illnesses of siblings: Diabetes 2.0 2.5 5.3 -1.5 1.8 -1.6 -1.5 2.2 1.6 1.2 0.6 -2.0 0.9 -2.3 -0.8
Smoking status: Previous 4.7 7.1 21.4 -3.3 -0.6 -3.7 -4.0 -0.1 -0.2 -1.6 -0.0 -4.6 0.3 -2.5 -3.7
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.1 31.9 -5.6 -0.9 -1.5 -1.9 -0.5 -1.7 -3.0 -1.0 -2.6 -1.2 -1.1 0.1
Whole body fat-free mass 3.1 18.0 44.4 -3.6 4.4 -5.7 -6.7 3.0 3.3 0.7 3.9 -4.1 4.4 -5.9 0.9
Leg fat-free mass (right) 3.0 16.2 37.7 -2.2 4.8 -4.6 -6.1 3.2 3.8 1.3 3.6 -3.4 5.0 -5.5 1.4
Arm fat percentage (left) 1.3 5.3 15.1 2.3 2.7 -1.1 -3.7 1.6 2.9 1.8 1.8 -0.8 3.9 -1.9 -0.2
Average weekly red wine intake 1.2 1.7 4.9 -0.1 -1.4 2.0 2.2 -1.6 -1.3 -0.6 -1.4 0.2 -1.4 0.9 -0.8
Handedness (chirality/laterality): Left-handed 0.6 0.7 4.2 -0.5 0.7 -2.1 -0.6 1.2 0.6 0.4 0.6 0.2 0.3 -1.0 0.3
Mood swings 0.2 0.4 2.0 1.4 -0.3 0.7 0.7 -0.9 -0.2 -0.0 -0.2 0.3 -0.6 0.7 -0.6
Loneliness, isolation 0.3 0.4 1.3 0.7 0.0 0.7 1.1 0.1 0.3 0.2 0.2 1.0 -0.2 0.8 0.5
Long-standing illness, disability or infirmity 1.0 1.5 3.4 -1.8 -1.4 -1.0 -1.2 0.3 -1.1 -1.5 -0.5 -1.7 -0.8 0.1 -1.6
Ever had bowel cancer screening 0.9 1.0 4.8 -1.9 -0.5 -1.0 -0.6 -0.0 -0.4 -1.0 0.0 -2.2 -0.2 -1.0 0.0
Diabetes diagnosed by doctor 3.0 5.0 14.7 -1.9 2.0 -3.4 -3.8 1.8 1.8 0.4 1.3 -2.0 1.8 -3.1 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 9.2 -1.8 0.0 -1.9 -1.0 1.2 -0.1 -0.3 -0.6 -1.4 -0.3 -0.6 -3.0
Friendships satisfaction 1.3 1.6 2.9 1.4 1.3 1.0 1.7 1.4 1.5 1.1 0.6 1.3 1.6 -1.2 0.4
Qualifications: nursing, teaching 0.6 0.9 3.9 -1.4 0.3 -1.0 0.3 1.4 0.3 0.7 0.0 -2.0 0.3 -0.7 -0.7
Commuting to job workplace: Walk 3.6 3.9 10.9 0.9 -2.0 2.8 3.0 -3.3 -1.8 -1.2 -1.9 0.0 -1.3 1.8 -1.2
Eye problems/disorders: Cataract 0.3 0.4 1.1 -0.4 0.5 -0.9 0.5 0.4 0.5 0.7 1.0 0.9 -0.2 -0.4 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 3.3 -0.2 1.6 -1.1 -1.4 0.7 1.4 0.9 0.4 -0.8 0.8 -1.8 0.3
Medication for cholesterol 2.3 3.5 9.1 2.2 2.1 -0.3 -0.4 3.0 2.0 1.9 1.1 2.5 1.4 -0.4 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.8 -1.5 0.2 -0.6 -1.7 -0.6 0.5 0.1 1.5 -1.4 0.4 -1.0 -0.4
Back pain experienced in last month 1.1 1.6 6.0 -1.2 -0.8 -0.9 -2.0 -0.5 -0.6 -1.3 -0.0 -2.5 0.6 -0.7 -1.8
Mineral and other dietary supplements 2.6 3.5 10.9 0.5 -1.9 2.3 2.9 -0.6 -1.4 -0.3 -0.6 3.3 -2.4 2.2 0.5
Breast cancer (self-reported) 0.2 0.3 1.2 0.4 -0.1 1.1 0.1 0.1 0.3 -0.2 0.4 0.3 1.0 -0.8 -0.2
Asthma (self-reported) 0.8 1.5 5.6 2.4 1.3 -0.4 -0.1 1.0 1.3 2.0 1.3 0.5 1.5 -0.1 -0.1
Osteoporosis (self-reported) 0.2 0.3 0.8 0.6 0.5 -0.6 0.3 -0.7 0.4 0.5 0.5 0.4 0.4 -0.3 -0.9
Osteoarthritis (self-reported) 0.6 0.8 4.0 0.6 0.1 0.1 -0.7 -2.0 -0.1 -0.3 0.2 -1.9 0.8 -0.1 -0.6
Medication: Aspirin 1.9 2.5 6.1 -1.9 -2.0 0.5 -0.1 -1.8 -1.5 -1.7 -1.1 -2.5 -1.5 0.4 -2.1
Medication: Gliclazide 0.6 0.6 3.4 -0.6 0.3 -0.8 -1.9 -0.4 0.5 0.0 0.5 -0.7 1.1 -0.9 -0.3
Illnesses of father: None of the above (group 1) 2.3 2.8 7.4 1.0 2.6 0.5 0.9 2.7 1.7 1.3 0.3 1.9 1.3 -1.3 2.5
Smoking status: Current 4.5 7.2 26.8 -3.1 0.8 -3.1 -5.2 -0.0 0.7 -1.8 0.3 -4.0 1.1 -2.6 -3.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 20.6 0.7 -1.0 0.8 0.5 -0.5 -0.6 -0.6 0.7 4.5 -0.5 1.2 1.7
Whole body water mass 3.1 18.0 44.8 -3.6 4.4 -5.8 -6.7 3.1 3.3 0.7 3.9 -4.0 4.4 -5.9 0.8
Leg predicted mass (right) 3.0 16.3 37.8 -2.2 4.8 -4.6 -6.1 3.2 3.8 1.4 3.6 -3.5 5.0 -5.5 1.4
Arm fat mass (left) 2.1 8.7 25.9 0.5 3.4 -2.9 -5.1 2.2 3.1 1.5 2.5 -2.3 4.4 -3.2 -0.2
Number of self-reported non-cancer illnesses 1.3 2.2 6.1 0.3 -1.3 0.8 1.4 -1.9 -1.6 -1.1 -2.0 -2.5 -1.0 1.6 -1.0
Average weekly champagne plus white wine intake 2.8 3.8 12.6 1.6 2.1 -0.4 -0.3 3.6 2.2 2.4 1.5 2.4 1.5 -0.9 2.1
Miserableness 0.4 0.7 2.9 -1.2 0.5 -0.9 -1.7 1.1 0.3 0.0 0.5 -1.0 0.1 -0.9 -0.2
Guilty feelings 0.7 1.1 2.6 1.3 0.6 0.6 1.4 0.4 0.8 1.6 1.0 1.3 0.4 0.1 1.5
Wears glasses or contact lenses 0.4 0.5 2.6 0.3 0.1 -0.5 -0.1 0.1 0.5 0.6 0.3 -1.6 0.6 -0.8 -0.9
Ever taken oral contraceptive pill 1.9 2.1 4.4 -0.1 1.8 -1.7 -1.8 1.8 1.6 1.6 2.1 0.5 1.2 -0.9 1.2
Hearing aid user 0.2 0.2 1.7 0.5 -0.1 -0.4 1.3 0.5 -0.1 0.2 -0.1 0.5 -0.1 0.3 -0.2
Mother’s age at death 0.3 0.3 1.4 -0.4 0.2 -0.1 0.3 1.2 0.4 0.7 0.7 0.8 0.0 -0.1 0.7
Financial situation satisfaction 1.3 1.6 5.4 -2.3 0.3 -1.5 -1.4 0.3 -0.0 -1.5 -0.5 -1.0 0.3 -2.1 -1.1
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.4 -1.2 0.0 -1.1 -0.2 0.0 -0.6 -0.7 -0.5 -0.0 -0.5 -0.2 0.8
Commuting to job workplace: Public transport 0.5 0.6 3.7 -0.4 -0.8 0.3 1.9 0.6 -0.4 0.1 -0.2 0.7 -1.0 0.4 -0.4
Eye problems/disorders: Glaucoma 0.3 0.3 1.7 -0.0 0.0 -1.0 -0.1 -0.1 0.4 0.1 0.5 -0.1 -0.4 -0.6 -1.3
Medication: Blood pressure 2.4 4.5 14.9 -2.3 -2.3 -0.2 0.2 -3.8 -1.6 -2.0 -1.0 -2.4 -1.0 -0.6 -3.9
Pain type(s) experienced in last month: Hip pain 0.7 0.9 5.5 2.4 0.4 0.6 -0.5 -0.7 0.6 0.6 0.1 -0.2 1.0 0.1 -1.5
Supplements: Fish oil (including cod liver oil) 0.8 1.0 6.4 -0.2 0.7 -0.7 -1.4 0.1 0.4 -0.1 -0.3 -2.5 1.1 -0.6 -1.0
High cholesterol (Self-reported) 0.2 0.4 1.4 -0.8 0.6 0.2 -0.7 -0.7 0.4 0.3 0.2 -1.2 0.5 -0.4 -0.6
Medication: Bendroflumethiazide 3.1 4.8 14.7 -3.2 -1.8 -1.2 -0.0 -2.2 -1.5 -2.0 -1.6 -3.8 -0.9 -0.8 -3.6
Medication: Paracetamol 1.1 1.7 5.1 -0.4 -1.9 0.4 0.9 -1.0 -1.9 -0.7 -0.5 -1.5 -1.6 2.3 -0.7
Medication: Lisinopril 2.5 3.2 5.9 -2.0 -1.9 0.6 2.0 -2.4 -2.2 -2.0 -2.0 -1.2 -2.0 0.9 -1.4
Medication: Atorvastatin 1.1 1.3 3.2 -0.3 -1.8 0.6 1.2 -1.6 -1.6 -1.0 -0.9 0.6 -1.4 1.2 -0.4
Illnesses of father: High blood pressure 1.6 2.0 5.8 -0.7 -2.1 0.8 0.2 -2.4 -1.5 -1.6 -1.4 -0.7 -0.9 0.6 -2.0
Alcohol drinker status: Never 0.3 0.4 1.1 0.8 -0.2 0.6 -0.1 -0.3 0.4 0.3 0.9 1.0 0.4 -0.3 1.1
Ever smoked 6.1 10.8 33.4 -4.2 -0.3 -4.3 -5.8 0.4 0.1 -2.3 -0.2 -5.3 0.4 -2.7 -4.5
Basal metabolic rate 3.0 17.2 45.4 -3.4 4.2 -5.5 -6.7 3.1 3.2 0.7 3.7 -4.0 4.5 -5.6 0.6
Leg fat percentage (left) 1.6 5.9 17.8 1.2 2.3 -2.4 -4.2 1.8 2.6 1.4 2.1 -1.3 3.8 -2.5 -0.9
Arm fat-free mass (left) 3.3 17.0 46.1 -3.4 4.0 -5.6 -6.8 2.7 3.1 0.6 3.8 -4.1 4.3 -5.6 0.3
Number of operations (self-reported) 0.9 1.3 3.6 1.1 1.1 -1.0 0.3 1.9 1.1 1.7 1.2 -0.4 1.3 -0.6 1.1
Average weekly beer plus cider intake 0.2 0.3 1.1 -0.7 0.4 -0.2 0.3 -0.6 -0.2 -0.4 -0.4 -1.0 -0.6 -0.1 -0.6
Irritability 0.8 1.4 4.5 -0.6 0.8 -1.6 -2.1 0.9 0.9 0.0 -0.0 -1.4 0.9 -2.0 -0.7
Risk taking 0.9 1.3 5.2 -0.7 -0.6 -0.4 -1.4 -1.7 -0.7 -1.5 -0.9 -2.3 0.3 -0.1 -1.0
Ever had prostate specific antigen (PSA) test 1.1 1.2 3.5 1.9 1.0 0.8 0.4 0.6 1.1 1.5 0.5 1.5 0.9 0.3 1.5
Fractured/broken bones in last 5 years 1.9 2.4 5.7 1.2 -1.6 2.0 1.8 -1.4 -1.5 -0.5 -1.6 0.2 -1.3 2.4 -1.9
Age started oral contraceptive pill 0.2 0.3 0.7 0.5 0.1 -0.5 -0.2 0.8 0.3 0.6 0.6 -0.7 0.8 -0.2 0.5
Diastolic blood pressure, automated reading 1.7 5.4 12.2 -3.2 -3.4 -0.0 0.2 -3.5 -2.5 -2.5 -1.5 -2.6 -1.0 -0.6 -2.9
Ever depressed for a whole week 1.3 1.6 5.9 -2.4 -0.8 -1.1 0.3 0.2 -1.2 -1.0 -1.2 -1.8 -1.2 -0.1 -1.4
Unable to work because of sickness or disability 0.6 0.8 2.3 -1.0 -1.2 0.3 -0.0 -0.8 -1.3 -1.5 -0.9 -0.1 -1.0 0.6 0.0
Commuting to job workplace: Cycle 1.1 1.4 2.5 -1.5 -1.3 0.3 1.0 -0.9 -1.6 -1.6 -1.5 0.1 -1.5 1.1 -0.0
Myopia 0.6 0.9 2.4 0.8 1.3 0.4 0.4 0.2 1.4 1.0 0.2 0.5 1.6 -1.6 0.5
Vascular/heart problems diagnosed by doctor 3.6 10.0 26.6 2.8 4.0 -0.7 -1.5 5.0 3.0 3.3 2.7 3.4 2.2 -0.4 5.2
Cholesterol lowering medication 0.5 0.7 2.8 -0.5 -0.9 0.8 0.1 -1.7 -0.8 -0.7 -0.0 -1.1 -0.5 0.6 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.2 -0.7 -0.5 0.1 0.1 -0.9 -0.9 -0.5 -1.0 -1.1 -0.8 0.9 -0.5
Pain experienced in last month 0.4 0.6 2.3 -0.6 0.9 -0.7 0.9 0.6 0.7 0.4 -0.2 1.5 -0.1 -0.8 0.8
Supplements: Calcium 0.6 0.7 3.0 0.3 0.6 0.1 -1.7 -0.1 0.7 0.5 0.5 -0.3 1.5 -0.6 -1.0
Basal cell carcinoma (self-reported) 1.2 1.5 5.1 -1.8 -0.8 -1.3 0.2 0.4 -1.3 -1.1 -1.0 -2.2 -1.5 0.7 -0.2
Heart attack/myocardial infarction (self-reported) 2.9 3.7 13.3 -0.8 -2.5 1.9 0.6 -3.6 -2.2 -1.9 -1.4 -0.7 -1.8 1.8 -1.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 1.8 1.0 -0.5 1.1 1.3 -0.7 -0.4 0.2 -0.5 1.4 -0.7 1.3 0.8
Heart disease (siblings) 2.2 2.7 6.4 -1.7 -2.5 0.1 -0.9 -2.0 -2.1 -1.7 -1.1 -1.9 -1.7 1.6 -0.9
Alcohol drinker status: Previous 1.2 1.3 2.8 -1.1 -1.2 1.0 1.0 -0.6 -1.4 -1.7 -1.2 -0.4 -1.5 1.2 -0.9
Pack years of smoking 2.7 4.0 11.6 -2.4 -1.2 -1.5 -2.3 -0.3 -1.6 -2.9 -1.9 -2.4 -0.9 0.6 -3.4
Impedance of whole body 3.3 17.3 36.5 -2.8 -6.0 3.3 5.1 -2.0 -5.2 -3.5 -4.7 0.0 -5.8 4.6 -2.7
Leg fat mass (left) 2.5 10.2 33.4 -0.3 3.2 -3.7 -5.8 2.5 3.1 1.2 2.6 -2.7 4.4 -3.7 -0.5
Arm predicted mass (left) 3.2 16.8 45.2 -3.6 4.0 -5.8 -6.7 2.9 3.0 0.5 3.6 -3.9 4.1 -5.6 0.3