Hub : Genes

C1orf27

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0880 0.0260 1.7e-08 0.022 0.077 0.079 0.078 0.070 8.3e-04 1.3e-09 6.9e-10 1.0e-09 6.7e-09
2 GTEx Brain Caudate basal ganglia 0.4870 0.1260 1.4e-03 0.000 NA -0.002 NA -0.006 3.2e-01 NA 3.7e-01 NA 5.0e-01
3 GTEx Brain Cerebellar Hemisphere 0.2220 0.0800 2.0e-03 0.218 NA 0.146 NA 0.197 2.8e-06 NA 1.4e-04 NA 8.8e-06
4 GTEx Brain Cerebellum 0.2470 0.0790 1.5e-04 0.153 NA 0.136 NA 0.157 2.8e-05 NA 8.1e-05 NA 2.2e-05
5 GTEx Brain Hippocampus 0.5056 0.1317 8.3e-04 0.044 NA 0.080 NA 0.076 3.5e-02 NA 6.4e-03 NA 7.8e-03
6 GTEx Brain Nucleus accumbens basal ganglia 0.2940 0.1260 9.0e-03 0.016 NA 0.018 NA -0.010 1.2e-01 NA 1.0e-01 NA 8.0e-01
7 GTEx Cells Transformed fibroblasts 0.2600 0.0670 6.7e-08 0.155 NA 0.162 NA 0.169 1.0e-11 NA 3.4e-12 NA 1.0e-12
8 GTEx Muscle Skeletal 0.1206 0.0355 4.8e-07 0.012 NA 0.070 NA 0.072 2.3e-02 NA 2.0e-07 NA 1.4e-07
9 GTEx Testis 0.2730 0.0700 5.0e-07 0.123 NA 0.079 NA 0.099 4.3e-06 NA 2.2e-04 NA 3.7e-05
10 GTEx Thyroid 0.0770 0.0320 9.7e-04 0.055 NA 0.033 NA 0.030 5.2e-05 NA 1.5e-03 NA 2.4e-03
11 METSIM Adipose 0.1031 0.0342 3.9e-08 0.050 0.060 0.051 0.053 0.043 4.8e-08 2.4e-09 4.3e-08 1.9e-08 3.9e-07
12 TCGA Brain Lower Grade Glioma 0.0818 0.0452 1.4e-05 0.033 0.036 0.030 NA 0.033 1.1e-04 5.8e-05 2.0e-04 NA 9.9e-05
13 TCGA Thyroid Carcinoma 0.0990 0.0400 1.6e-07 0.023 0.079 0.073 NA 0.063 2.2e-03 4.1e-08 1.2e-07 NA 8.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.3 0.4 1.6 0.7 -1.3 -0.3 -0.2 1.1 0.0 -0.2 -0.2 0.7 0.7 0.9 -0.1 0.2
Bipolar Disorder or Schizophrenia 0.3 0.7 2.1 0.2 -1.2 0.5 0.4 1.0 0.0 -0.5 -0.4 1.5 0.9 1.3 -0.6 -0.5
Depressed Affect (Nagel 2018) 0.2 0.4 1.2 -0.2 1.1 0.0 -0.2 1.1 0.0 0.8 -0.6 -0.9 -0.2 -0.4 0.0 0.4
Depression (Nagel 2018) 0.6 0.9 4.0 -0.5 -1.7 1.1 0.8 0.9 0.0 2.0 0.0 -0.2 0.5 -0.9 0.6 0.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 1.1 0.5 0.8 0.1 0.3 -0.4 0.0 -0.7 0.5 1.1 0.5 0.3 0.1 -0.3
Neuroticism (Nagel 2018) 0.2 0.5 2.1 -0.3 0.7 -0.7 -1.1 0.1 0.0 0.5 -0.9 -1.4 -0.4 -0.4 -0.1 0.7
Schizophrenia (2018) 0.2 0.5 1.8 -0.3 -0.7 0.9 0.7 0.3 0.0 -0.5 -0.3 1.4 0.6 0.8 -0.6 -0.8
Schizophrenia vs Biploar Disorder 0.4 0.6 2.6 0.9 0.4 -0.2 0.2 -0.4 0.0 -0.5 1.6 0.8 -0.5 1.5 0.2 0.2
Worry (Nagel 2018) 0.5 1.1 5.1 -0.5 1.0 -1.3 -1.7 -0.6 0.0 0.4 -1.2 -2.3 0.3 -0.2 0.0 1.4
Alzheimer’s Disease (in mother) 1.1 1.3 3.8 1.8 1.4 0.1 0.4 0.5 0.0 0.2 0.6 -0.2 1.6 1.4 1.4 1.9
Alzheimer’s Disease (in father) 0.3 0.3 1.5 0.1 0.3 0.6 0.7 -0.2 0.0 -1.2 0.5 1.0 -0.4 0.1 -0.6 -0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 2.3 1.2 1.5 0.4 0.5 0.1 0.0 -1.0 0.5 0.5 1.0 1.0 0.6 1.0
Crohns Disease (2017) 0.6 1.4 3.7 -1.0 -1.0 -0.6 -1.3 0.8 0.0 -0.8 -1.8 -1.6 -1.2 -1.9 -1.4 -0.2
Irritable Bowel Disease (IBD) 0.5 1.2 4.2 -0.6 -0.4 -0.8 -1.3 0.1 0.0 -1.3 -2.0 -2.0 -0.2 -1.0 -0.9 0.5
Ulcerative Colitis (UC) 0.8 1.5 5.3 -0.7 0.2 -1.0 -1.3 -1.0 0.0 -1.8 -2.2 -2.3 0.4 -0.7 -0.5 0.6
Major Depression (MDD) 0.9 1.1 5.3 -0.7 -2.3 -0.5 -0.9 -0.8 0.0 -0.6 -1.4 -0.1 -1.1 -0.2 -1.5 -1.1
Reaction Time 0.3 0.6 2.0 -0.1 -0.1 -0.9 -0.9 -1.4 0.0 -0.9 -0.1 -0.1 -0.8 -0.5 -1.3 -0.2
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.4 -0.1 0.4 -0.6 -0.5 -1.1 0.0 -1.2 -0.5 -0.6 0.3 -0.1 0.3 0.5
Breast Cancer 0.4 0.9 3.0 -0.2 0.5 1.7 1.6 0.6 0.0 1.5 0.9 0.9 0.1 -1.0 0.7 -0.6
Ovarian Cancer 0.4 0.6 1.7 -0.5 1.1 -0.4 -0.4 -1.0 0.0 -0.9 -0.3 0.3 -1.1 -0.5 -0.5 -1.3
Prostate Cancer 1.7 2.4 7.0 0.7 -0.5 -2.4 -2.3 -2.2 0.0 -1.0 -1.3 -2.6 0.1 0.7 -0.0 2.1
Age at First Birth 0.8 1.2 4.8 0.2 0.3 -2.2 -1.6 -0.4 0.0 -1.9 -0.5 0.2 -0.8 1.6 -0.9 -0.1
Bipolar Disorder (2011) 0.6 0.6 1.4 -0.9 -0.8 0.2 -0.3 1.1 0.0 0.7 -1.2 -0.9 0.9 -1.1 -0.1 0.5
Body Mass Index (BMI) (2010) 0.7 1.0 4.4 0.0 -2.1 -0.3 -0.3 -0.8 0.0 1.2 -1.1 -1.9 -0.7 -0.6 -0.2 -0.1
Coronary Artery Disease (CAD) 0.9 1.1 5.1 -1.1 0.5 0.7 1.2 0.3 0.0 -0.3 -0.1 0.5 -1.4 -2.3 -0.7 -1.7
Crohns Disease (2012) 1.4 2.3 4.5 -0.7 -1.7 -1.8 -2.1 -0.3 0.0 -1.5 -1.5 -1.6 -2.1 -2.1 -1.6 -0.5
Mean Putamen Volume 0.7 0.8 3.9 -1.2 0.0 -0.5 -0.9 -0.3 0.0 -0.5 -1.9 -2.0 0.2 0.1 0.2 0.5
Fasting Glucose 0.8 0.9 3.3 1.4 1.0 -0.6 -0.1 0.1 0.0 0.6 -0.2 -0.6 1.8 1.1 1.2 1.4
HbA1C 0.9 1.0 4.3 0.4 1.3 -0.9 -1.3 -0.6 0.0 -0.6 -1.0 -2.1 0.8 0.6 0.5 1.3
HDL Cholesterol 0.1 0.1 0.8 0.1 -0.4 -0.1 0.0 -0.1 0.0 -0.3 0.2 0.1 0.3 0.9 0.4 0.4
LDL Cholesterol 0.2 0.3 1.3 -0.5 0.4 -0.1 -0.3 -0.2 0.0 0.5 -0.5 -1.1 0.4 0.1 0.4 0.9
Lupus 0.8 1.2 2.9 -0.3 0.4 -1.5 -1.7 -1.1 0.0 -1.3 -1.2 -1.3 -1.2 -0.9 -1.2 -0.0
Neuroticism (2016) 0.1 0.2 0.5 -0.5 0.2 0.0 -0.4 -0.1 0.0 0.6 -0.5 -0.7 0.3 -0.4 0.0 0.3
Primary Biliary Cirrhosis 1.7 2.5 7.7 1.4 0.9 -2.0 -1.9 -0.3 0.0 -0.9 -1.1 -2.8 1.3 1.7 1.2 2.5
Rheumatoid Arthritis 1.0 1.4 4.9 -0.8 0.7 0.7 -0.1 -1.1 0.0 0.4 -2.1 -2.2 1.8 -1.4 0.0 0.8
Schizophrenia (2014) 0.2 0.4 1.1 0.1 -0.3 -0.4 -0.6 -0.2 0.0 -1.0 -0.7 0.7 0.5 1.0 -1.0 -0.3
Triglycerides 1.0 1.7 9.1 0.6 -1.0 -0.5 -0.6 -0.8 0.0 1.2 -0.9 -3.0 0.8 -1.1 1.1 2.2
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.4 1.0 0.0 -1.5 -1.2 0.3 0.0 0.3 -1.6 -1.5 1.3 1.3 0.5 1.3
Ulcerative Colitis 0.7 1.0 2.8 0.9 0.5 -1.2 -1.1 -0.7 0.0 -1.1 -0.7 -1.7 0.8 0.9 0.4 1.7
Blood Eosinophil Count 0.2 1.3 5.3 0.1 -0.1 0.3 -0.4 0.5 0.0 0.5 -1.8 -2.3 1.6 -1.5 0.1 1.6
Blood Platelet Count 0.1 1.7 3.8 1.4 1.4 -1.5 -1.5 -0.2 0.0 0.4 -1.2 -1.9 1.7 0.5 1.3 1.9
Blood Red Count 0.2 2.1 8.9 -2.3 -0.4 0.8 0.2 -0.2 0.0 0.4 -0.9 0.2 -1.7 -3.0 -1.9 -2.1
Blood White Count 0.1 0.8 3.1 0.2 0.2 -0.9 -1.2 -0.1 0.0 0.3 -1.6 -1.8 -0.8 -1.1 -1.0 -0.1
Heel T-Score 0.2 1.4 6.8 1.0 0.6 0.8 1.3 0.6 0.0 -0.2 2.0 2.6 -0.8 1.2 -0.0 -1.3
BMI 0.3 2.0 11.2 -0.5 -0.2 -0.1 -0.8 -0.5 0.0 1.8 -1.9 -3.4 -0.2 -2.3 -0.2 1.1
Height 0.1 2.0 5.6 0.5 2.1 1.1 1.4 -1.2 0.0 1.4 1.3 -0.4 1.5 1.4 2.4 1.8
Waist Hip Ratio (WHR) 0.1 0.5 2.1 -0.1 -1.4 -0.7 -0.5 -0.6 0.0 -1.1 -0.2 0.8 -0.6 0.3 -0.8 -0.8
Systolic Blood Pressure 0.1 0.7 3.3 0.1 1.3 -1.1 -1.0 -0.3 0.0 -0.6 0.2 -0.8 -1.8 -0.1 -0.7 0.0
Smoking Status 0.3 0.7 2.7 0.5 1.6 0.6 0.5 1.0 0.0 1.4 0.5 -0.3 0.9 0.1 0.7 0.8
Allergy or Eczema 0.1 0.3 0.8 0.3 0.9 -0.4 -0.6 0.4 0.0 0.4 -0.7 -0.4 0.5 -0.9 0.1 0.2
Cardiovascular Disease 0.4 1.4 3.6 1.3 0.1 -1.9 -1.3 1.1 0.0 0.8 0.4 -1.8 -0.2 1.0 1.1 1.8
Hypothyroidism (self reported) 0.3 0.7 3.2 -0.1 1.8 1.3 1.3 -0.5 0.0 0.1 0.6 0.6 0.7 -0.8 0.6 -0.2
Respiratory disease 0.9 2.1 5.5 -1.3 -1.2 -0.5 -0.7 -2.3 0.0 -2.2 -1.4 -0.3 -1.0 -2.1 -1.5 -1.9
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.9 1.2 -0.2 0.5 1.1 0.9 0.0 0.9 1.7 1.2 0.3 1.4 0.8 0.3
Lung FEV1/FVC ratio 0.7 3.7 8.5 0.7 2.4 -0.0 0.3 2.9 0.0 1.9 -0.6 -2.9 1.5 2.8 2.6 2.0
Lung FVC 0.2 1.0 4.5 1.9 -2.1 -0.1 -0.2 -1.2 0.0 0.2 0.5 1.3 -0.5 -0.3 -0.4 -0.7
Neuroticism 0.2 0.4 2.0 -0.5 0.3 -0.0 -0.4 0.2 0.0 0.6 -1.0 -1.4 -0.1 -0.9 -0.2 0.1
Chronotype (morning person) 1.0 2.4 7.7 -2.0 -0.4 -1.3 -1.5 -0.6 0.0 -1.4 -1.6 -0.9 -2.8 -1.4 -1.9 -1.8
Hair Pigment 0.1 1.5 4.6 -2.1 -0.4 -0.2 -0.7 -1.6 0.0 -1.2 -1.4 -1.3 -1.1 -1.6 -1.2 -0.8
Tanning 0.2 2.1 5.8 -0.4 0.3 -1.3 -1.6 -2.4 0.0 -2.1 -1.1 0.2 -1.9 -0.7 -2.4 -1.6
Hand grip strength (left) 0.6 1.5 5.8 1.5 0.2 -2.4 -1.8 -0.3 0.0 -0.6 -0.1 -1.5 -0.8 1.9 0.5 1.2
Number of treatments/medications taken 2.5 4.5 10.1 -1.8 -0.7 -2.7 -3.1 -2.8 0.0 -1.9 -3.2 -2.4 -1.5 -2.1 -2.0 -0.6
Average weekly spirits intake 4.2 5.2 10.3 -3.1 -1.4 -1.4 -2.2 -2.3 0.0 -2.7 -3.0 -1.2 -2.0 -3.2 -3.1 -1.8
Sensitivity / hurt feelings 0.2 0.3 1.1 0.1 0.2 -0.4 -0.8 -0.5 0.0 -0.7 -1.0 -0.6 0.7 -0.7 -0.3 0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.4 -0.2 0.5 1.2 0.9 0.4 0.0 1.0 0.3 -0.1 0.9 -0.4 0.7 0.7
Hearing difficulty/problems: Yes 0.3 0.4 0.9 -1.0 -0.1 -0.9 -0.8 0.6 0.0 -0.6 -0.9 -0.7 -0.1 0.8 0.4 -0.2
Relative age of first facial hair 1.8 3.6 10.9 2.3 2.5 -0.3 0.2 -0.5 0.0 0.2 0.9 -0.9 2.9 3.3 2.2 3.2
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 7.1 -0.9 0.2 1.2 1.1 1.8 0.0 2.7 0.1 -0.8 0.4 0.5 1.1 0.6
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.7 -0.5 -0.6 -1.5 -1.4 0.5 0.0 -1.6 -0.3 0.6 -1.6 -0.1 -1.5 -1.0
Ever had hysterectomy (womb removed) 0.2 0.2 1.1 -0.3 0.3 0.1 -0.1 1.0 0.0 0.6 -0.4 0.7 -0.0 0.2 -0.5 -0.5
Systolic blood pressure, automated reading 0.3 0.8 4.5 -0.4 0.6 -0.8 -0.8 -0.7 0.0 -0.6 -0.5 -0.8 -2.1 -0.7 -1.0 -0.7
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 4.2 -1.0 -0.1 -1.6 -1.8 -0.3 0.0 -1.1 -1.5 -1.2 -1.7 -0.4 -2.1 -0.4
Angina 0.3 0.4 2.2 -1.5 -0.6 0.5 0.3 0.1 0.0 -0.4 0.0 -0.7 -1.0 -0.6 -0.4 -0.2
Medication for hormone replacement therapy 0.5 0.6 2.2 0.5 -0.6 -1.3 -1.5 -0.3 0.0 -0.6 -0.5 0.2 -0.9 0.0 -1.1 -0.3
Vitamin and mineral supplements 2.0 2.7 13.5 0.5 1.1 2.0 2.0 2.5 0.0 3.7 1.0 -0.3 1.2 0.5 1.6 0.9
Supplements: Zinc 0.4 0.4 1.4 0.3 0.6 -1.2 -1.0 0.5 0.0 -0.4 -0.3 -0.6 -0.9 -0.4 -0.7 -0.0
Medication: Co-codamol 2.0 2.3 7.2 0.8 -0.5 -2.7 -2.6 -0.6 0.0 -1.9 -1.9 -2.4 -0.4 0.4 -0.5 1.1
Medication: Metformin 0.1 0.2 0.7 -0.8 0.1 0.6 0.6 0.1 0.0 -0.0 -0.0 0.3 -0.1 -0.4 -0.3 -0.8
Diabetes (father) 1.2 1.4 10.3 -0.7 -3.2 -1.0 -1.1 -1.5 0.0 -0.0 -0.8 -1.1 -0.9 -0.7 -0.5 0.1
Diabetes (mother) 1.0 1.3 4.8 -2.1 1.2 0.2 -0.2 1.1 0.0 0.2 -1.8 -2.2 0.2 -1.1 -0.1 0.4
Severe depression (siblings) 3.2 3.5 7.1 2.1 0.8 2.1 2.6 2.0 0.0 1.5 2.7 2.1 1.8 1.8 2.3 0.4
Pack years adult smoking proportion 0.5 0.7 3.2 0.4 -0.5 -1.1 -1.3 -0.7 0.0 0.2 -0.6 -1.8 0.1 -0.1 0.0 1.5
Impedance of leg (right) 0.7 3.5 17.2 2.3 -0.6 -0.1 0.9 2.1 0.0 -0.0 3.3 4.2 0.1 2.2 0.8 -0.5
Leg fat-free mass (left) 0.4 2.3 14.4 -0.7 -0.0 -0.3 -0.9 -2.5 0.0 1.0 -1.9 -3.8 -0.3 -1.3 0.1 1.5
Trunk fat percentage 1.1 4.5 14.1 -1.3 -0.9 -0.8 -1.7 -3.7 0.0 -1.1 -3.0 -2.7 -1.5 -3.7 -2.2 -0.4
Hand grip strength (right) 0.2 0.6 1.7 1.0 -0.1 -1.3 -1.0 -0.3 0.0 -0.1 -0.2 -1.2 -0.5 1.1 0.5 0.7
Townsend deprivation index at recruitment 0.5 0.6 2.1 -1.4 0.7 0.4 0.1 0.6 0.0 -0.9 -0.9 0.1 -0.1 -1.4 -0.8 -1.1
Current tobacco smoking 0.7 1.2 4.5 0.6 -0.5 -0.1 -0.5 -0.2 0.0 2.1 -0.9 -2.1 0.8 -1.4 1.0 1.1
Average weekly fortified wine intake 0.3 0.3 1.3 -0.3 -0.2 -1.0 -0.9 -0.8 0.0 -1.1 -0.3 -0.2 -0.5 -0.2 -0.5 0.0
Maternal smoking around birth 0.2 0.2 0.9 0.4 0.3 0.5 0.5 0.8 0.0 0.3 0.5 0.4 0.4 -1.0 0.1 -0.2
Fed-up feelings 0.3 0.5 3.3 0.6 0.9 0.5 0.4 -0.0 0.0 1.8 0.0 -0.8 -0.0 -1.0 0.3 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 6.2 0.3 -0.6 1.7 1.7 1.9 0.0 2.5 0.9 0.1 1.6 -0.4 1.9 1.0
Relative age voice broke 1.9 2.9 13.9 2.0 1.6 1.3 1.2 -1.2 0.0 0.7 0.4 -0.1 3.7 1.8 2.0 2.3
Taking other prescription medications 1.4 2.2 6.3 -1.8 -0.2 -1.0 -1.5 -1.5 0.0 -0.2 -2.4 -2.5 -0.7 -2.5 -0.8 -0.3
Age when periods started (menarche) 0.3 0.8 3.1 -1.8 -1.6 0.1 -0.3 -0.8 0.0 0.5 -1.5 -0.9 0.2 -0.8 -0.1 -0.5
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 5.4 -0.3 -2.0 -2.3 -2.0 -1.5 0.0 -2.0 -1.2 0.0 -0.4 1.3 -0.7 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.5 4.1 1.2 -0.9 1.4 2.0 1.4 0.0 0.7 2.0 1.7 0.0 0.5 1.0 -0.3
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 6.0 1.8 0.2 1.5 1.5 0.2 0.0 2.1 0.7 -0.7 2.5 0.7 2.4 2.0
Qualifications: CSEs or equivalent 0.1 0.2 0.5 -0.6 -0.7 0.3 0.1 -0.1 0.0 -0.2 -0.6 -0.5 0.7 -0.3 0.1 0.6
Serious illness, injury or assault to yourself 0.3 0.3 1.1 0.4 -0.2 -1.0 -1.0 0.1 0.0 -0.6 -0.8 -0.7 0.3 0.3 -0.2 0.5
High blood pressure 0.2 0.6 3.1 0.4 -0.1 -1.0 -0.8 0.7 0.0 0.9 -0.3 -1.8 -0.4 -0.0 0.5 1.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.7 0.1 0.8 -0.5 -0.8 0.4 0.0 -0.2 -0.7 -0.4 0.4 -0.8 -0.2 0.1
Multivitamins +/- minerals 0.9 1.2 5.6 -0.1 -0.1 -0.8 -1.0 -2.2 0.0 -2.4 -1.0 0.2 -0.3 -0.9 -0.8 -0.7
Stomach or abdominal pain in last month 0.9 1.1 4.5 2.1 1.4 -0.3 0.3 0.2 0.0 -0.5 1.8 1.5 -0.3 1.1 0.5 0.2
Supplements: Glucosamine 0.9 1.1 2.9 -1.4 -1.1 0.1 -0.2 -1.2 0.0 -1.7 -0.8 0.5 -0.8 -1.3 -1.3 -1.5
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.5 0.5 -1.2 -0.5 -0.2 -1.2 0.0 0.7 0.3 -0.6 -0.9 0.0 0.6 0.3
Medication: Atenolol 0.3 0.4 1.4 -0.7 0.2 0.3 0.1 -0.7 0.0 0.5 -0.9 -1.2 0.8 0.5 0.6 0.5
Medication: Levothyroxine sodium 0.4 0.6 1.6 -1.0 0.8 0.8 0.7 -0.9 0.0 -0.8 0.2 0.9 -0.4 -1.0 -0.4 -1.3
Sitting height 0.1 0.9 2.2 -0.4 1.3 0.8 1.0 -1.5 0.0 1.3 1.0 -0.5 0.6 0.7 1.4 1.0
Chronic bronchitis/emphysema (father) 2.1 2.4 6.4 -0.8 0.2 -1.6 -1.6 -1.5 0.0 -2.2 -1.2 0.3 -2.5 -0.7 -2.4 -2.1
High blood pressure (mother) 1.9 2.7 5.6 -1.9 1.5 -1.6 -1.7 -1.9 0.0 -2.4 -1.7 -1.4 -2.0 -1.4 -1.4 -1.1
Body mass index (BMI) 0.6 2.5 9.1 -1.0 -0.2 -0.1 -0.9 -2.0 0.0 -0.3 -2.4 -2.8 -1.3 -3.0 -1.5 -0.3
Impedance of leg (left) 0.7 3.5 20.3 1.9 0.2 0.4 1.3 2.0 0.0 -0.6 3.4 4.5 0.0 1.8 0.5 -1.0
Leg predicted mass (left) 0.4 2.3 13.7 -0.8 -0.0 -0.3 -0.9 -2.5 0.0 0.9 -1.9 -3.7 -0.4 -1.3 0.0 1.4
Trunk fat mass 1.0 4.2 13.9 -1.3 -0.7 -0.7 -1.6 -3.7 0.0 -0.6 -2.8 -3.1 -1.5 -3.4 -1.9 -0.0
Waist circumference 0.8 3.1 8.9 -1.4 -0.2 -0.7 -1.2 -3.0 0.0 -1.2 -2.1 -2.2 -2.1 -2.6 -2.1 -0.7
Number of incorrect matches in round 1.4 2.3 6.6 -2.2 -1.7 -0.4 -0.8 -0.6 0.0 -1.3 -1.6 0.5 -1.9 -1.2 -1.9 -2.6
Past tobacco smoking 0.3 0.6 2.3 0.4 -0.7 0.2 0.1 0.1 0.0 1.4 -0.7 -1.5 0.7 -0.8 1.1 0.8
Alcohol usually taken with meals 0.1 0.1 0.5 -0.4 0.1 0.0 0.2 0.4 0.0 -0.0 0.4 0.5 -0.4 0.7 0.0 -0.3
Nervous feelings 0.1 0.1 0.6 -0.2 -0.3 -0.2 -0.5 0.0 0.0 0.2 -0.2 -0.7 0.3 -0.3 0.0 0.8
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.9 0.1 0.3 1.1 0.8 1.7 0.0 2.0 0.1 -1.1 1.9 0.1 1.8 2.0
Hearing difficulty/problems with background noise 0.3 0.4 2.5 -1.2 0.3 0.2 0.1 1.6 0.0 -0.7 -0.4 0.3 0.7 -0.1 0.2 -0.6
Hair/balding pattern: Pattern 2 0.3 0.4 1.1 0.4 0.7 1.1 0.9 0.4 0.0 0.8 -0.3 -0.6 1.0 -0.6 0.7 0.3
Had menopause 0.4 0.5 1.7 -0.0 -0.7 0.3 0.5 1.3 0.0 0.7 0.9 0.9 -0.9 -0.1 0.1 -0.7
Had other major operations 0.3 0.3 3.3 -0.2 0.5 -0.1 -0.3 1.8 0.0 0.1 -0.2 -0.2 0.3 0.7 0.2 0.4
Forced vital capacity (FVC) 0.3 1.1 4.6 2.1 0.1 0.3 0.6 0.1 0.0 1.4 1.6 0.7 0.8 1.0 1.2 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 3.1 1.5 -0.7 0.6 1.3 0.8 0.0 0.7 1.8 1.1 -0.0 0.8 1.0 0.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 3.0 1.5 0.0 -0.8 -0.7 -0.1 0.0 0.7 -0.0 -1.3 0.4 0.4 0.6 1.7
Qualifications: None of the above 0.2 0.5 1.7 -0.2 -1.2 0.7 0.4 0.5 0.0 1.1 -0.4 -0.3 0.0 -1.3 -0.5 -0.2
Financial difficulties in last 2 years 0.2 0.3 0.9 0.5 0.7 0.5 0.7 -0.3 0.0 -0.1 0.9 0.4 -0.6 0.1 -0.0 -0.6
Mouth/teeth dental problems 1.0 1.6 6.4 1.1 0.4 0.7 1.5 0.5 0.0 0.1 2.4 2.5 0.3 1.8 1.1 -0.3
Heart attack 0.3 0.4 2.3 -0.3 -1.5 0.6 0.3 0.5 0.0 0.9 -0.5 -0.7 0.2 -0.6 -0.1 0.4
Allergy 0.6 1.5 5.1 0.6 0.5 1.0 1.5 1.0 0.0 1.0 2.2 1.4 -0.0 2.3 1.0 0.5
Pain all over the body in last month 0.1 0.1 0.4 0.3 -0.3 0.3 0.5 0.3 0.0 0.6 0.6 -0.1 -0.1 0.4 -0.0 0.6
Diabetes (self-reported) 0.1 0.2 0.7 0.3 0.2 0.2 0.5 0.0 0.0 -0.1 0.7 0.8 -0.4 0.8 -0.4 -0.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.2 0.6 -1.1 -0.3 -0.2 0.4 0.0 -0.2 0.1 0.9 -0.1 -0.1 -0.2 -0.5
Medication: Ramipril 1.9 2.4 5.3 1.8 0.7 1.2 1.6 1.6 0.0 2.0 1.5 0.2 2.1 1.4 2.3 1.8
Medication: Simvastatin 0.7 1.0 3.4 1.0 -0.7 -0.1 0.4 0.7 0.0 1.7 1.0 -0.3 0.9 1.0 1.8 1.4
Fluid intelligence score 0.2 0.3 1.6 0.1 0.8 -0.7 -0.5 -0.8 0.0 -1.3 0.2 0.1 0.2 0.5 0.3 0.2
Illnesses of siblings 0.3 0.4 0.9 -0.6 -0.0 -0.8 -0.7 -1.0 0.0 -0.7 -0.1 0.5 -0.7 -0.4 -0.6 -0.8
Neuroticism score 0.5 1.1 4.5 -0.3 0.2 -1.0 -1.5 -1.2 0.0 -0.2 -1.7 -2.1 0.0 -1.2 -0.6 0.8
Weight 0.5 2.3 10.2 -1.0 0.2 -0.3 -1.0 -2.5 0.0 0.1 -2.1 -3.2 -1.1 -2.3 -1.0 0.5
Impedance of arm (right) 0.2 1.1 3.6 1.4 -1.5 -1.0 -0.8 -1.3 0.0 -0.2 -0.2 0.0 1.9 0.9 1.0 1.4
Arm fat percentage (right) 1.1 4.3 13.7 -1.2 -1.2 -0.5 -1.5 -3.4 0.0 -0.8 -3.2 -3.1 -0.9 -3.7 -1.8 -0.2
Trunk fat-free mass 0.1 0.9 4.5 -0.1 0.7 0.3 0.2 -0.3 0.0 1.7 -0.0 -2.1 0.1 0.2 1.1 1.4
Hip circumference 0.4 1.9 7.2 -1.2 1.0 0.3 -0.3 -2.0 0.0 -0.1 -1.5 -1.8 -1.5 -2.7 -1.5 -0.6
Time employed in main current job 0.4 0.4 1.1 -0.6 -0.6 -0.3 -0.6 0.3 0.0 -0.5 -0.6 0.2 -0.9 -0.8 -1.0 -1.0
Alcohol intake versus 10 years previously 0.8 1.1 4.0 1.3 1.2 -0.0 0.0 -0.4 0.0 -0.0 0.1 -0.1 1.9 2.0 0.7 1.8
Father’s age at death 0.9 1.2 4.6 -0.7 -0.2 -0.8 -1.1 -2.1 0.0 -1.0 -1.2 0.0 -0.8 -1.6 -1.6 -0.8
Worrier / anxious feelings 0.5 1.0 3.3 -0.4 0.7 -1.3 -1.8 -0.8 0.0 0.2 -1.5 -1.8 0.0 -0.5 -0.3 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 2.2 0.5 1.5 0.7 0.6 -0.4 0.0 -0.0 0.2 -0.6 0.6 -0.5 0.2 1.0
Falls in the last year 1.2 1.6 7.0 1.1 0.7 0.3 0.1 -0.1 0.0 0.9 -0.3 -1.3 2.7 1.2 1.7 2.2
Hair/balding pattern: Pattern 3 1.4 2.1 5.8 2.4 -0.4 0.0 0.4 1.0 0.0 0.7 2.0 1.0 1.9 2.4 1.8 1.6
Number of live births 1.0 1.4 5.6 -1.1 -2.0 -0.2 -0.8 -0.4 0.0 1.0 -1.3 -1.1 -1.0 -2.4 -1.3 -0.4
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.9 1.7 0.2 -0.0 0.3 0.4 0.0 1.5 0.9 -0.5 0.6 1.1 1.6 1.4
Pulse rate 0.1 0.1 0.9 0.3 0.5 0.3 0.0 0.2 0.0 0.2 -0.3 -0.0 1.0 -0.5 0.3 0.3
Happiness 1.2 1.5 3.0 1.2 0.2 1.4 1.5 0.9 0.0 1.7 1.3 -0.4 1.3 0.9 1.7 1.4
Noisy workplace 0.5 0.6 2.2 0.0 0.0 0.2 -0.0 -0.2 0.0 1.2 -0.5 -1.5 0.9 0.5 1.4 1.0
Qualifications: A levels/AS levels or equivalent 1.0 2.3 5.1 1.1 0.3 -1.9 -1.4 -1.8 0.0 -0.4 -0.2 -2.1 1.3 2.1 2.0 2.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.8 -0.3 0.5 -0.8 -0.9 -0.2 0.0 -0.5 -0.9 -0.4 -0.1 -0.3 -0.6 -0.1
Mouth/teeth dental problems: Dentures 0.9 1.5 4.4 -0.8 -1.9 0.2 -0.4 1.9 0.0 1.5 -1.3 -2.1 0.8 -1.2 0.5 1.0
Asthma 0.6 1.2 6.2 -0.7 -0.2 -0.2 -0.4 -2.5 0.0 -1.7 -1.3 -0.8 0.2 -1.7 -0.5 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 3.6 -0.9 0.9 0.7 -0.2 -1.3 0.0 -1.2 -1.7 -0.1 1.3 -1.9 -1.4 -0.4
Medication: Cholesterol lowering 0.3 0.5 1.7 0.1 -0.6 0.8 0.9 1.3 0.0 0.7 0.3 0.1 0.8 0.8 1.0 0.4
Depression (self-reported) 1.1 1.3 3.4 -1.4 -0.7 -0.7 -0.9 -0.9 0.0 -1.5 -1.0 -0.1 -1.9 -0.9 -1.5 -1.6
Medication: Lansoprazole 0.7 0.7 2.8 -1.7 -1.1 1.4 1.0 1.2 0.0 0.2 -0.3 0.3 0.2 -0.8 -0.2 -0.5
Prospective memory result 0.7 0.8 2.6 -1.1 -1.0 -0.1 -0.5 0.3 0.0 0.7 -1.2 -0.9 -1.2 -1.6 -0.7 -1.1
Lung cancer (father) 0.8 0.9 5.7 -0.8 0.7 -0.4 -0.4 -0.8 0.0 -2.4 -0.4 0.9 -0.3 -0.8 -1.4 -1.0
Illnesses of mother 1.4 1.8 5.3 1.9 -1.5 0.4 1.0 1.3 0.0 1.7 2.3 1.7 0.8 1.1 1.1 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 4.4 2.1 -0.1 -0.1 0.2 0.3 0.0 1.8 1.2 -0.6 0.8 1.9 1.7 1.9
Pulse wave Arterial Stiffness index 1.0 1.1 4.7 -0.6 -0.2 -0.7 -0.7 0.4 0.0 -1.6 -0.4 0.2 -2.2 -0.8 -1.9 -1.3
Impedance of arm (left) 0.2 0.8 2.5 0.8 -1.3 -1.1 -1.1 -1.6 0.0 -0.6 -0.7 0.0 1.4 0.4 0.3 0.9
Arm fat mass (right) 0.8 3.3 11.1 -1.0 -0.4 -0.5 -1.3 -3.1 0.0 -0.2 -2.6 -3.3 -1.0 -3.0 -1.3 0.3
Trunk predicted mass 0.2 0.9 4.5 -0.0 0.7 0.3 0.2 -0.3 0.0 1.7 -0.0 -2.1 0.2 0.2 1.1 1.5
Standing height 0.1 0.9 2.3 -0.0 1.0 -0.1 0.1 -0.9 0.0 1.4 0.7 -1.0 0.4 1.3 1.4 1.5
Length of working week for main job 2.0 2.3 5.5 0.7 1.8 1.5 1.4 2.0 0.0 1.7 0.4 -0.6 2.3 0.7 2.0 2.0
Exposure to tobacco smoke at home 1.3 1.5 5.7 2.2 0.0 -1.0 -1.0 -0.7 0.0 0.8 0.1 -1.5 1.2 0.5 1.1 2.4
Breastfed as a baby 1.0 1.2 4.0 0.4 0.5 2.0 1.9 0.1 0.0 1.1 1.1 1.0 1.6 0.2 1.0 0.5
Tense / ‘highly strung’ 0.6 0.9 3.4 -0.2 0.5 0.3 -0.1 -0.6 0.0 1.0 -0.5 -1.6 1.8 -0.5 1.2 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 5.4 -0.9 1.3 -2.2 -2.3 -0.8 0.0 -1.9 -1.5 -1.3 -1.2 -0.1 -1.4 -0.1
Hair/balding pattern: Pattern 4 1.0 2.4 8.9 -3.0 0.9 -0.8 -1.0 -0.2 0.0 -1.6 -1.6 -0.6 -2.4 -1.7 -2.0 -1.5
Birth weight of first child 0.9 1.6 6.5 -0.6 -2.5 -0.7 -1.1 -1.4 0.0 0.7 -1.9 -2.0 -0.3 -1.5 -0.3 0.3
Peak expiratory flow (PEF) 0.2 0.4 1.8 1.3 0.1 0.7 1.0 -0.3 0.0 0.0 0.9 0.5 0.3 0.4 0.9 -0.1
Pulse wave reflection index 0.4 0.5 2.2 -0.3 -0.2 0.3 0.4 0.1 0.0 -0.7 0.2 0.7 -1.5 -0.6 -1.1 -1.2
Ever highly irritable/argumentative for 2 days 0.8 0.9 3.4 0.8 0.1 -1.3 -1.1 0.6 0.0 0.8 -0.4 -1.8 0.1 1.4 0.4 1.4
Loud music exposure frequency 0.3 0.3 2.4 0.4 1.6 0.0 -0.0 0.9 0.0 0.3 0.3 0.0 0.4 0.3 0.5 0.5
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 5.1 1.3 -1.4 -1.3 -0.8 -0.6 0.0 0.8 0.5 -1.4 1.2 2.1 2.0 2.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.6 -0.1 0.4 -1.1 -1.2 -1.1 0.0 -1.2 -0.7 -1.0 -1.3 -0.2 -1.1 -0.2
Blood clot in the leg (DVT) 3.5 4.5 11.2 -1.7 -1.1 -1.9 -2.4 -2.1 0.0 -2.0 -3.3 -2.0 -2.0 -3.1 -2.2 -1.6
Medication: Paracetamol 1.4 2.4 7.2 -0.7 0.5 -1.6 -2.0 -1.8 0.0 -2.2 -1.5 -0.0 -1.4 -1.5 -2.7 -1.6
Headache pain in last month 0.4 0.7 2.6 -0.5 0.2 1.1 0.6 1.0 0.0 0.6 -1.0 -1.0 1.1 -1.6 0.1 -0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.9 -1.0 0.7 0.3 0.0 -0.9 0.0 -0.6 -0.5 0.5 0.1 -0.8 -0.6 -0.6
Glaucoma (self-reported) 1.2 1.4 4.9 -1.2 -2.2 -0.9 -0.9 -1.3 0.0 -0.8 -0.4 -0.4 -1.9 -1.1 -1.0 -1.2
Gout (self-reported) 1.3 1.7 4.6 1.8 -0.1 0.5 0.9 -0.6 0.0 1.9 1.0 -0.7 1.8 1.2 2.1 1.9
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.9 -0.7 1.7 1.0 0.7 -1.5 0.0 0.0 -0.2 -0.4 0.3 -1.5 0.3 -0.3
Medication: Amlodipine 0.3 0.4 2.6 -0.1 0.2 0.7 0.8 1.6 0.0 0.6 0.5 0.7 0.6 0.3 0.5 0.1
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.2 1.1 1.7 -1.8 -1.5 -1.7 0.0 -0.2 -0.2 -1.4 -0.0 0.3 0.1 1.0
Birth weight 0.6 1.2 2.9 -1.7 1.4 1.1 0.4 -0.5 0.0 -0.4 -0.4 0.9 -0.7 -1.5 -1.6 -1.6
Chronic bronchitis/emphysema (mother) 0.9 1.1 4.0 -1.1 1.2 -0.5 -0.9 -1.2 0.0 -0.5 -2.0 -1.1 -0.7 -1.2 -0.9 -1.1
High blood pressure (siblings) 0.2 0.2 0.9 -0.5 0.3 0.4 0.2 0.8 0.0 0.0 -0.5 -0.9 0.3 -0.1 -0.1 0.9
Forced vital capacity (FVC), Best measure 0.3 1.0 3.1 1.8 -0.9 -0.0 0.2 -0.7 0.0 1.3 1.5 0.1 0.4 1.1 1.0 1.4
Body fat percentage 0.9 3.5 11.8 -1.1 -0.7 -0.6 -1.4 -3.2 0.0 -1.0 -2.5 -2.3 -1.5 -3.4 -2.1 -0.5
Leg fat percentage (right) 0.5 1.8 7.2 -0.6 -0.5 -0.3 -0.7 -1.5 0.0 -0.9 -1.4 -0.9 -2.0 -2.7 -2.0 -1.1
Arm fat-free mass (right) 0.1 0.5 1.7 -0.5 0.9 0.5 0.4 -0.5 0.0 1.0 0.0 -1.3 -1.0 -0.7 -0.1 0.2
Exposure to tobacco smoke outside home 1.0 1.3 4.9 0.9 -0.1 -2.2 -1.8 -1.9 0.0 -1.3 -0.2 -0.7 -0.7 0.9 -0.5 0.9
Comparative body size at age 10 0.2 0.5 3.1 1.8 1.1 -0.0 -0.1 -0.5 0.0 0.4 -0.6 -0.9 0.3 -0.2 0.4 0.6
Number of full brothers 1.2 1.5 4.1 1.0 -1.1 0.8 1.1 2.0 0.0 2.0 1.2 0.4 1.3 0.4 1.6 1.0
Worry too long after embarrassment 0.0 0.0 0.4 -0.1 0.0 0.1 -0.0 -0.1 0.0 0.6 -0.2 0.1 0.2 0.1 0.4 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.5 0.2 0.4 -1.2 -1.2 -1.1 0.0 -1.1 -0.6 -1.2 -0.2 0.2 -0.0 0.6
Wheeze or whistling in the chest in last year 0.9 1.6 8.1 0.1 0.4 -1.0 -1.4 -2.8 0.0 -1.6 -1.7 -1.7 -0.1 -0.4 -1.2 0.5
Number of children fathered 2.0 2.3 11.3 -0.6 1.5 2.1 2.1 3.4 0.0 1.7 1.2 1.4 -0.3 -0.3 0.4 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.2 0.9 0.3 0.7 1.1 1.5 0.0 0.8 1.5 0.6 1.0 0.9 1.5 0.8
Age at first live birth 1.2 2.2 7.0 -0.2 2.5 1.4 1.7 0.9 0.0 -0.7 1.8 2.6 -1.0 0.5 -0.4 -2.1
Pulse wave peak to peak time 0.8 0.9 3.8 0.3 0.1 0.6 0.5 -0.6 0.0 1.6 0.3 -0.3 2.0 0.6 1.7 1.2
Health satisfaction 0.7 0.9 3.2 0.4 1.2 -0.9 -0.9 -1.1 0.0 -0.6 -0.5 -1.8 0.9 0.2 0.4 1.6
Shortness of breath walking on level ground 3.1 3.7 10.2 -3.2 0.1 -0.3 -0.9 -1.9 0.0 -1.7 -2.2 -1.6 -2.5 -2.9 -2.2 -1.9
Qualifications: College or University degree 0.3 1.0 2.7 -0.2 1.1 0.1 0.1 -0.2 0.0 0.9 -0.2 -1.5 1.6 1.1 1.5 1.6
Eye problems/disorders: None of the above 0.6 0.7 3.2 0.7 0.6 0.9 1.0 0.7 0.0 0.0 0.4 1.0 1.8 0.6 1.0 0.2
Mouth/teeth dental problems: Loose teeth 0.4 0.4 2.5 1.0 -0.7 0.6 0.6 0.2 0.0 1.6 0.5 -0.1 0.3 -0.4 0.4 -0.2
Emphysema/chronic bronchitis 0.7 0.7 2.0 -1.0 -1.4 0.0 -0.4 -0.4 0.0 0.4 -0.6 0.0 -1.1 -1.1 -1.4 -1.2
Medication for pain relief, constipation, heartburn 1.3 2.3 6.5 1.1 -0.2 0.9 1.5 2.5 0.0 1.9 2.5 1.1 -0.1 1.9 2.0 0.5
Neck or shoulder pain in last month 0.6 0.9 3.0 0.1 -0.4 -1.7 -1.7 -0.6 0.0 -0.6 -0.9 -1.2 -1.2 -0.4 -0.7 -0.1
Medication: Blood pressure 0.0 0.1 0.3 0.6 -0.1 0.1 0.2 0.3 0.0 0.2 0.4 -0.3 -0.1 0.1 0.2 0.3
Angina (self-reported) 0.3 0.4 2.2 -1.5 -0.7 0.4 0.2 -0.1 0.0 -0.4 0.0 -0.8 -1.1 -0.6 -0.4 -0.2
Migraine (self-reported) 0.9 1.1 6.6 1.4 0.7 -0.8 -0.2 0.2 0.0 -1.4 0.6 1.1 0.9 2.6 0.6 0.4
Medication: Ibuprofen 0.8 0.9 3.8 -1.2 0.5 0.5 -0.2 -0.4 0.0 -1.2 -1.4 0.1 0.7 -1.9 -1.3 -0.8
Medication: Allopurinol 0.7 1.0 3.4 1.4 0.3 -0.0 -0.0 -0.3 0.0 1.4 -0.3 -1.5 1.3 0.2 1.0 1.9
Medication: Omeprazole 0.8 1.0 6.1 -0.6 1.4 0.2 -0.2 -2.5 0.0 -0.8 -1.0 -0.5 -0.4 -1.3 -0.8 -0.4
Medication: Seretide 50 evohaler 0.8 0.9 2.2 -0.4 -0.7 -0.9 -1.2 -1.1 0.0 -1.5 -1.5 -1.4 0.8 -1.0 -0.4 0.7
Mean time to correctly identify matches 0.8 1.5 4.4 -1.2 -1.0 -1.2 -1.4 -1.5 0.0 -1.2 -1.0 -0.3 -1.7 -1.3 -2.1 -1.1
Heart disease (mother) 0.2 0.2 0.7 -0.5 0.8 -0.3 -0.3 -0.6 0.0 0.4 -0.2 -0.7 -0.5 0.6 0.0 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.3 -0.0 -0.6 1.1 1.1 0.9 0.0 0.4 0.9 1.0 0.1 -0.7 0.3 -0.4
Whole body fat mass 0.8 3.5 12.0 -1.1 -0.4 -0.5 -1.3 -3.5 0.0 -0.4 -2.4 -3.0 -1.5 -3.3 -1.7 -0.1
Leg fat mass (right) 0.6 2.2 8.1 -1.0 -0.4 -0.1 -0.7 -2.4 0.0 -0.5 -1.7 -1.9 -1.9 -2.9 -1.8 -0.7
Arm predicted mass (right) 0.1 0.5 2.9 -0.5 0.6 0.4 0.3 -0.6 0.0 1.2 -0.1 -1.7 -0.7 -0.5 0.3 0.6
Pulse rate, automated reading 0.3 1.1 4.1 -1.6 -0.7 0.3 -0.2 1.0 0.0 -0.3 -0.8 0.3 -1.0 -2.0 -1.1 -1.7
Alcohol intake frequency. 0.2 0.4 1.9 -0.0 0.3 0.1 -0.2 -1.4 0.0 -0.2 -0.4 -0.6 -0.6 -0.9 -1.1 0.0
Comparative height size at age 10 0.1 0.5 2.2 -0.3 -0.1 -0.7 -0.6 0.6 0.0 1.2 0.2 -1.1 -1.5 0.1 -0.1 0.4
Number of full sisters 1.4 1.8 5.2 0.5 1.5 2.3 2.2 1.0 0.0 1.3 1.2 1.2 1.8 0.6 1.0 0.4
Suffer from ‘nerves’ 0.2 0.4 1.4 -0.9 0.4 0.0 -0.4 -1.2 0.0 -0.0 -0.8 -0.6 -0.1 -1.0 -0.5 0.3
Overall health rating 0.4 0.8 3.5 0.3 -0.2 -0.6 -0.8 -0.9 0.0 0.6 -1.0 -1.9 0.8 0.0 0.1 1.6
Chest pain or discomfort 0.7 1.0 4.5 -1.3 -0.3 0.5 0.0 -0.8 0.0 0.1 -0.9 -0.6 -1.3 -2.1 -1.1 -1.2
Had major operations 0.8 0.9 2.7 0.9 -0.5 -1.1 -1.3 -1.6 0.0 -0.1 -1.0 -1.5 0.7 0.5 0.5 0.9
Age at last live birth 1.0 1.4 4.8 0.5 2.2 0.7 1.1 1.7 0.0 0.4 2.1 1.7 -0.1 1.1 0.7 -0.2
Family relationship satisfaction 1.1 1.3 4.9 2.2 -0.3 -1.4 -0.9 0.3 0.0 0.2 1.0 -0.4 0.3 1.9 0.7 1.9
Leg pain on walking 1.0 1.2 4.3 -1.1 1.7 1.6 1.0 1.1 0.0 1.1 -0.3 -0.6 -0.3 -2.1 -0.5 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 5.1 0.6 2.3 2.1 1.9 1.9 0.0 0.5 0.7 1.8 0.7 -0.5 0.2 -1.2
Commuting to job workplace: Car/motor vehicle 0.7 0.8 4.6 -0.7 2.2 1.3 0.8 1.1 0.0 -0.2 -0.2 1.1 0.5 -0.1 -0.7 -0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.6 -0.9 -1.1 -0.1 -0.0 0.4 0.0 -0.4 -0.3 0.2 -1.3 -0.2 -0.4 -1.1
Medication: Aspirin 0.4 0.6 3.3 0.1 -0.3 -0.6 -0.4 -1.8 0.0 -0.4 -0.3 -0.8 0.7 0.6 0.5 1.1
Supplements: Vitamin C 1.1 1.3 7.5 -0.5 -0.6 -1.5 -1.3 -0.1 0.0 -2.7 -0.4 0.7 -0.8 0.9 -1.5 -0.8
Knee pain experienced in last month 0.3 0.5 2.5 -0.5 0.0 1.3 0.9 -0.3 0.0 1.6 -0.0 -0.5 0.2 -0.9 0.5 0.1
Hypertension (Self-reported) 0.2 0.5 2.3 0.3 0.2 -1.1 -1.0 0.5 0.0 0.3 -0.4 -1.5 -0.5 -0.0 0.2 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.4 -1.5 -1.4 0.4 -0.2 0.0 0.0 -0.2 -1.5 -0.7 -0.5 -1.5 -0.8 -1.1
Illnesses of father: Heart disease 1.4 2.0 8.1 -1.2 -1.5 -0.9 -0.8 -0.0 0.0 -2.4 -0.1 0.1 -2.8 -0.9 -1.3 -2.1
Illnesses of siblings: Diabetes 0.6 0.8 3.1 -0.3 -1.3 1.1 1.0 -0.2 0.0 1.4 0.2 -0.7 0.0 -1.8 0.4 -0.3
Smoking status: Previous 0.6 0.9 5.1 -0.5 0.6 0.4 0.6 0.6 0.0 -1.0 1.1 2.2 -0.1 1.3 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.2 0.9 0.8 -1.0 -0.6 -1.2 0.0 0.9 0.8 -1.1 -0.1 0.8 0.8 1.5
Whole body fat-free mass 0.2 1.1 7.5 -0.4 0.6 0.2 -0.1 -1.2 0.0 1.4 -0.7 -2.7 -0.0 -0.5 0.7 1.4
Leg fat-free mass (right) 0.4 2.2 13.5 -0.9 0.5 -0.2 -0.8 -2.5 0.0 0.7 -1.9 -3.7 -0.2 -1.3 0.1 1.4
Arm fat percentage (left) 1.3 5.0 14.5 -1.3 -1.1 -0.9 -1.8 -3.8 0.0 -1.0 -3.4 -3.2 -1.3 -3.8 -2.1 -0.3
Average weekly red wine intake 0.6 0.8 4.3 -0.9 -2.1 -1.1 -1.1 0.6 0.0 0.3 -0.8 -1.3 -0.8 -0.1 0.0 0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 3.3 0.5 -0.3 0.1 0.1 1.8 0.0 -0.5 0.3 0.6 0.3 0.3 -0.1 0.2
Mood swings 0.2 0.3 1.5 -0.6 -0.1 0.1 -0.1 -0.0 0.0 0.3 -0.6 -0.6 -0.8 -1.2 -0.5 -0.5
Loneliness, isolation 0.8 1.1 3.1 -0.9 1.3 0.0 -0.3 -1.5 0.0 -1.8 -1.0 -0.3 -0.8 -1.4 -1.4 -0.9
Long-standing illness, disability or infirmity 0.7 1.0 5.5 -0.0 0.6 -1.0 -1.0 -1.5 0.0 0.6 -1.3 -2.4 -0.0 0.2 0.4 1.1
Ever had bowel cancer screening 0.4 0.5 1.6 -1.3 1.0 -0.5 -0.6 -0.2 0.0 -0.9 -1.1 -1.0 -0.3 -0.2 -0.6 -0.0
Diabetes diagnosed by doctor 0.1 0.2 0.5 -0.0 -0.5 0.0 0.3 0.0 0.0 -0.1 0.3 0.5 -0.7 0.4 -0.5 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 -0.2 -0.9 -0.2 0.1 1.0 0.0 0.2 0.8 0.2 0.2 0.6 0.7 0.5
Friendships satisfaction 0.6 0.8 3.0 1.7 -0.6 -1.4 -1.2 -0.7 0.0 -0.9 0.2 -0.5 0.0 0.5 0.1 1.2
Qualifications: nursing, teaching 0.3 0.5 2.8 0.5 -0.3 -1.1 -0.8 0.4 0.0 -0.7 0.6 0.5 -0.4 1.7 0.2 0.2
Commuting to job workplace: Walk 0.2 0.2 1.0 -0.6 1.0 -0.6 -0.5 0.4 0.0 -0.2 -0.2 -0.5 -0.4 0.5 -0.0 -0.0
Eye problems/disorders: Cataract 1.5 1.7 6.4 1.1 1.2 1.3 1.4 1.4 0.0 2.5 1.1 0.3 1.3 1.3 1.4 1.0
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.3 -1.4 0.9 -0.6 -1.1 -0.5 0.0 -1.5 -1.5 -0.2 -0.6 -0.9 -1.8 -0.8
Medication for cholesterol 1.1 1.6 6.8 0.3 0.0 2.6 2.5 0.4 0.0 1.1 1.4 1.2 1.5 0.0 1.1 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.6 0.4 -0.5 -0.1 -0.2 -0.2 0.0 0.5 -0.4 -0.8 -0.0 -0.5 0.1 0.3
Back pain experienced in last month 1.5 2.1 5.7 0.0 1.8 -2.4 -2.3 -0.2 0.0 -1.8 -0.8 -0.4 -2.4 0.2 -1.8 -0.5
Mineral and other dietary supplements 2.6 3.5 7.6 1.6 1.6 1.5 2.1 2.0 0.0 2.7 2.1 0.6 1.9 2.1 2.8 1.4
Breast cancer (self-reported) 1.4 1.7 4.8 1.1 -0.2 0.3 0.5 2.2 0.0 1.8 0.8 0.0 1.6 2.0 1.6 1.6
Asthma (self-reported) 0.7 1.3 5.7 -1.0 -0.2 -0.1 -0.3 -2.4 0.0 -1.9 -1.2 -0.4 0.1 -1.7 -0.7 -1.2
Osteoporosis (self-reported) 1.0 1.3 4.2 -2.0 -0.5 0.1 -0.5 1.4 0.0 -0.4 -1.3 0.5 -1.1 -1.1 -1.7 -1.6
Osteoarthritis (self-reported) 0.4 0.5 3.2 -0.6 0.3 -0.1 -0.4 -1.8 0.0 -1.3 -0.9 -0.3 0.0 -0.1 -0.6 0.0
Medication: Aspirin 0.4 0.5 3.8 -0.1 -0.7 -0.7 -0.6 -1.9 0.0 -0.7 -0.3 -0.6 0.2 0.1 0.2 0.6
Medication: Gliclazide 0.5 0.5 1.9 -1.0 -0.6 0.7 0.5 -0.7 0.0 -0.1 -0.3 0.5 -0.7 -0.9 -0.8 -1.4
Illnesses of father: None of the above (group 1) 0.5 0.6 4.1 0.6 0.1 0.1 -0.0 0.2 0.0 0.7 -0.5 -0.4 2.0 -0.0 0.7 1.5
Smoking status: Current 0.5 0.9 3.7 0.4 -0.3 -0.4 -0.7 -0.5 0.0 1.6 -0.9 -1.9 0.3 -1.3 0.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 3.0 1.5 -0.0 0.6 0.9 1.0 0.0 1.7 1.6 0.9 -0.0 0.6 1.0 0.0
Whole body water mass 0.2 1.2 8.5 -0.5 0.5 0.1 -0.2 -1.3 0.0 1.4 -0.9 -2.9 -0.2 -0.6 0.6 1.4
Leg predicted mass (right) 0.4 2.2 13.7 -0.9 0.5 -0.1 -0.7 -2.4 0.0 0.8 -1.8 -3.7 -0.1 -1.3 0.1 1.4
Arm fat mass (left) 0.9 3.8 12.8 -1.1 -0.3 -0.6 -1.5 -3.2 0.0 -0.1 -2.9 -3.6 -1.2 -3.3 -1.5 0.2
Number of self-reported non-cancer illnesses 1.4 2.4 6.7 -1.0 -0.8 -2.6 -2.6 -1.2 0.0 -1.8 -1.9 -2.0 -1.5 -0.9 -0.9 -0.4
Average weekly champagne plus white wine intake 0.9 1.2 4.2 1.3 2.0 0.5 0.8 0.0 0.0 0.2 1.6 1.7 1.0 1.3 0.8 -0.0
Miserableness 0.4 0.8 4.4 -0.7 0.3 -0.3 -0.7 -0.3 0.0 0.2 -1.5 -2.1 -0.1 -1.2 -0.2 0.7
Guilty feelings 0.4 0.5 2.6 -0.7 0.4 -0.2 -0.5 -1.6 0.0 -1.2 -1.0 -0.2 -0.2 -0.3 -0.7 -0.4
Wears glasses or contact lenses 1.2 1.4 4.4 -0.8 0.5 -0.9 -1.0 -1.3 0.0 -2.1 -0.5 0.6 -1.4 -0.9 -1.9 -1.3
Ever taken oral contraceptive pill 1.2 1.3 5.3 0.3 0.7 0.7 1.1 2.0 0.0 -0.9 1.6 2.3 -0.4 1.1 -0.1 -1.1
Hearing aid user 0.2 0.2 1.3 -1.1 -0.3 0.3 0.1 0.1 0.0 0.3 -0.7 -0.7 0.0 -0.1 0.2 0.1
Mother’s age at death 0.2 0.3 0.8 -0.9 0.3 0.3 0.2 -0.8 0.0 -0.2 -0.2 0.4 -0.3 -0.8 -0.4 -0.9
Financial situation satisfaction 0.3 0.3 1.7 -0.4 -0.6 0.5 0.5 0.6 0.0 0.8 -0.3 -0.4 -0.4 -1.3 0.1 -0.4
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.8 0.2 0.2 -1.4 -1.0 -0.1 0.0 -1.2 0.1 1.1 -0.8 1.7 -0.7 -0.6
Commuting to job workplace: Public transport 0.5 0.6 1.6 0.4 -1.2 -0.7 -0.5 -0.9 0.0 0.7 0.1 -1.1 0.7 -0.0 1.2 1.0
Eye problems/disorders: Glaucoma 1.1 1.3 3.3 -1.5 -1.7 -0.5 -0.5 -1.5 0.0 -1.1 -0.0 0.1 -1.8 -1.3 -1.0 -1.5
Medication: Blood pressure 0.4 0.8 3.7 0.3 0.2 -1.9 -1.6 0.2 0.0 -0.3 -0.9 -1.2 -0.6 0.7 -0.1 0.7
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.5 0.5 0.6 -1.2 -1.0 -1.1 0.0 -0.6 -0.3 -0.9 -1.6 0.0 -0.7 0.1
Supplements: Fish oil (including cod liver oil) 0.9 1.2 4.0 -1.0 -1.3 -0.3 -0.8 -2.0 0.0 -1.2 -1.2 -0.6 -0.6 -1.5 -1.4 -0.3
High cholesterol (Self-reported) 0.5 0.9 2.4 -1.6 -1.5 -0.7 -0.8 0.2 0.0 0.2 -1.3 -1.1 -1.1 -1.1 -0.2 -0.8
Medication: Bendroflumethiazide 0.6 0.9 3.0 1.0 1.4 -1.7 -1.5 -0.3 0.0 -0.8 -0.1 -0.5 -0.4 1.1 -0.3 0.8
Medication: Paracetamol 1.4 2.2 5.0 -0.9 0.4 -1.7 -1.9 -1.8 0.0 -2.2 -1.6 -0.0 -1.3 -1.4 -2.1 -1.6
Medication: Lisinopril 1.3 1.7 4.1 -1.4 -2.0 -2.0 -1.9 -1.2 0.0 -1.4 -1.6 -1.0 -1.1 0.1 -0.9 -0.3
Medication: Atorvastatin 2.0 2.5 7.5 -1.5 -1.4 -0.8 -1.2 -0.2 0.0 -1.2 -2.1 -0.8 -2.4 -1.9 -2.7 -1.8
Illnesses of father: High blood pressure 0.4 0.5 2.1 -0.7 -0.9 -1.0 -1.1 0.4 0.0 0.0 -0.8 -1.4 -0.0 0.4 0.3 0.7
Alcohol drinker status: Never 0.3 0.3 1.0 0.4 -1.0 -0.9 -0.8 -0.5 0.0 -0.4 -0.1 -0.4 -0.2 0.7 -0.1 0.8
Ever smoked 0.4 0.7 2.3 -0.9 -0.1 -0.9 -0.9 -1.5 0.0 -1.5 -0.2 0.1 -1.0 0.1 -1.2 -0.5
Basal metabolic rate 0.2 1.3 8.6 -0.5 0.5 0.0 -0.3 -1.6 0.0 1.1 -1.1 -2.9 -0.3 -1.0 0.2 1.2
Leg fat percentage (left) 0.5 2.0 8.5 -0.7 0.1 -0.0 -0.5 -1.6 0.0 -1.1 -1.4 -0.7 -1.9 -2.9 -2.1 -1.3
Arm fat-free mass (left) 0.2 0.8 4.2 -0.6 0.9 0.6 0.3 -0.7 0.0 1.5 -0.4 -2.0 -0.5 -1.0 0.4 0.7
Number of operations (self-reported) 0.3 0.4 1.1 -0.5 1.0 -0.7 -0.9 0.3 0.0 -0.6 -0.8 -0.7 -0.5 0.5 -0.6 0.0
Average weekly beer plus cider intake 0.7 1.0 2.5 0.6 -1.4 -0.6 -0.4 0.8 0.0 0.4 -0.6 -0.8 1.6 1.3 1.4 1.4
Irritability 0.6 1.0 4.7 0.2 -0.0 -1.0 -1.1 -2.2 0.0 -1.2 -0.7 -0.7 -1.1 -0.7 -1.3 -0.3
Risk taking 0.4 0.6 2.9 0.3 0.7 0.5 0.3 0.4 0.0 0.6 -0.4 -0.7 1.7 0.9 0.9 1.3
Ever had prostate specific antigen (PSA) test 1.5 1.7 4.5 -0.2 -0.8 -1.9 -2.1 -2.1 0.0 -2.0 -1.5 -0.5 -0.7 -0.3 -1.6 -0.3
Fractured/broken bones in last 5 years 0.4 0.5 1.8 0.2 0.6 -0.6 -0.9 -0.8 0.0 0.3 -1.3 -1.2 0.4 -0.1 -0.3 0.4
Age started oral contraceptive pill 0.8 1.0 3.5 -0.7 -1.7 0.0 0.3 1.1 0.0 0.0 0.2 1.3 -1.6 -0.6 -0.6 -1.9
Diastolic blood pressure, automated reading 0.2 0.6 2.2 1.4 1.5 -0.8 -0.4 -0.3 0.0 0.1 0.9 -0.4 -1.2 0.3 -0.1 0.5
Ever depressed for a whole week 0.1 0.2 0.6 0.2 0.6 -0.2 -0.4 0.3 0.0 0.3 -0.6 -0.8 -0.2 0.1 -0.6 0.5
Unable to work because of sickness or disability 0.8 1.1 3.5 -0.6 -0.4 -0.7 -1.1 -1.9 0.0 -1.0 -1.8 -1.4 -0.5 -0.9 -1.0 -0.2
Commuting to job workplace: Cycle 0.5 0.6 2.0 -1.4 -0.5 0.8 0.6 -1.0 0.0 0.1 -0.1 0.0 -0.5 -1.4 -0.6 -0.7
Myopia 0.3 0.4 1.2 -0.8 -0.6 0.7 0.7 1.1 0.0 0.5 0.7 0.0 -0.9 0.3 -0.1 -0.4
Vascular/heart problems diagnosed by doctor 0.2 0.6 3.0 -0.2 0.0 1.1 0.9 -0.6 0.0 -0.7 0.3 1.7 0.7 -0.2 -0.2 -0.9
Cholesterol lowering medication 0.8 1.2 3.8 -1.6 -2.0 -0.7 -0.8 -0.9 0.0 0.1 -0.9 -1.0 -1.1 -1.7 -0.5 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 5.4 -0.0 1.7 -0.2 -0.5 -2.3 0.0 -0.4 -1.1 -1.0 0.2 -0.5 -0.4 0.4
Pain experienced in last month 0.8 1.3 3.7 -0.8 -0.9 1.9 1.9 1.1 0.0 -0.2 0.9 1.9 1.5 0.6 0.6 -0.3
Supplements: Calcium 3.2 3.5 7.3 -1.1 0.7 -2.3 -2.7 -2.5 0.0 -2.1 -2.4 -1.6 -1.7 -1.7 -2.3 -0.9
Basal cell carcinoma (self-reported) 0.7 0.8 3.4 -1.2 -1.9 -0.3 -0.1 -1.4 0.0 -1.3 -0.5 0.5 -0.3 0.6 -0.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.2 -0.4 -1.5 0.5 0.2 0.5 0.0 0.7 -0.7 -1.0 0.2 -0.5 -0.1 0.5
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 8.8 -1.5 -0.8 -1.5 -2.0 -2.2 0.0 -1.8 -2.9 -1.8 -1.8 -3.0 -1.9 -1.5
Heart disease (siblings) 0.2 0.3 0.8 -0.1 0.9 0.9 0.9 0.7 0.0 -0.3 0.3 -0.3 -0.0 0.9 0.2 0.3
Alcohol drinker status: Previous 1.0 1.1 3.2 -1.3 1.8 -0.5 -0.8 -1.6 0.0 -0.6 -0.6 -0.8 -1.2 -1.1 -1.4 -0.5
Pack years of smoking 0.3 0.4 1.4 0.3 -0.4 -0.9 -0.9 -0.6 0.0 -0.3 -0.2 -1.1 0.0 0.2 -0.0 1.2
Impedance of whole body 0.2 0.8 5.2 1.1 -0.7 -0.3 0.1 -0.2 0.0 -0.7 1.2 2.3 0.7 0.8 0.3 -0.2
Leg fat mass (left) 0.7 2.7 10.2 -1.2 -0.1 -0.1 -0.7 -2.5 0.0 -0.9 -1.8 -1.7 -2.0 -3.2 -2.1 -1.0
Arm predicted mass (left) 0.1 0.7 3.8 -0.4 0.8 0.4 0.1 -0.6 0.0 1.2 -0.3 -2.0 -0.8 -1.0 0.2 0.6