Hub : Genes

CBS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1630	0.0460	1.3e-04	0.003	0.044	0.035	0.032	0.011	1.3e-01	4.4e-06	4.2e-05	7.7e-05	1.3e-02
2	GTEx	Lung	0.1032	0.0419	5.2e-03	0.049	NA	0.035	NA	0.056	1.2e-04	NA	1.1e-03	NA	4.2e-05
3	GTEx	Nerve Tibial	0.1721	0.0544	1.2e-04	0.080	NA	0.139	NA	0.147	2.5e-06	NA	4.7e-10	NA	1.5e-10
4	GTEx	Pancreas	0.3420	0.1270	2.1e-03	0.081	NA	0.152	NA	0.184	2.8e-04	NA	6.0e-07	NA	3.2e-08
5	GTEx	Pituitary	0.3570	0.1300	6.3e-03	0.203	NA	-0.004	NA	0.123	8.0e-06	NA	4.2e-01	NA	5.4e-04
6	GTEx	Whole Blood	0.2450	0.0560	1.7e-07	0.102	NA	0.141	NA	0.112	1.2e-09	NA	5.6e-13	NA	1.7e-10
7	METSIM	Adipose	0.0677	0.0235	5.7e-04	0.001	0.018	0.009	0.021	0.005	2.2e-01	9.5e-04	1.6e-02	3.5e-04	5.4e-02
8	NTR	Blood	0.1318	0.0211	0.0e+00	0.114	0.104	0.121	0.127	0.129	8.2e-35	8.5e-32	7.5e-37	6.3e-39	2.6e-39
9	TCGA	Breast Invasive Carcinoma	0.0263	0.0159	6.4e-03	0.007	0.004	0.003	NA	0.007	1.4e-02	3.8e-02	7.2e-02	NA	1.1e-02
10	TCGA	Rectum Adenocarcinoma	0.2450	0.1180	1.4e-03	0.050	0.112	0.054	NA	0.043	2.6e-02	1.4e-03	2.1e-02	NA	3.5e-02
11	TCGA	Skin Cutaneous Melanoma	0.4770	0.1260	1.3e-03	-0.006	0.108	0.155	NA	0.031	5.0e-01	8.3e-04	6.0e-05	NA	5.0e-02
12	TCGA	Thyroid Carcinoma	0.0570	0.0280	3.5e-05	0.028	0.036	0.014	NA	0.031	9.4e-04	1.9e-04	1.4e-02	NA	5.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.7	1.1	6.4	0.1	0.1	0.2	1.5	0.5	2.0	0.5	2.5	0.0	0.2	0.1	-0.2
Bipolar Disorder or Schizophrenia	0.8	1.9	4.5	0.5	2.0	1.9	2.1	2.0	1.1	1.6	1.6	0.0	-0.2	-0.3	-0.3
Depressed Affect (Nagel 2018)	0.4	0.8	2.5	1.6	0.8	1.0	1.3	1.2	-0.4	-0.2	0.0	0.0	-0.2	-0.6	-1.3
Depression (Nagel 2018)	0.5	0.8	3.3	0.1	0.1	0.1	0.8	0.7	0.1	-0.1	-0.0	0.0	-1.6	-1.5	-1.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.1	-0.4	2.0	0.4	0.1	1.2	-1.7	0.4	-1.6	0.0	-0.2	0.5	-0.3
Neuroticism (Nagel 2018)	0.7	1.7	5.7	1.6	1.0	0.5	1.3	1.4	-1.5	0.1	-1.4	0.0	-1.4	-1.0	-2.4
Schizophrenia (2018)	0.9	1.9	6.1	0.5	2.5	2.4	1.6	2.2	-0.2	1.7	-0.0	0.0	-0.4	-0.5	-0.3
Schizophrenia vs Biploar Disorder	1.7	2.3	10.3	0.8	1.3	0.8	-0.2	1.3	-3.2	0.5	-3.0	0.0	-1.0	0.0	-1.4
Worry (Nagel 2018)	0.5	1.2	4.6	1.1	0.2	-0.6	1.1	0.7	-1.3	-0.6	-1.1	0.0	-1.3	-0.8	-2.2
Alzheimer’s Disease (in mother)	0.4	0.5	2.2	-1.1	-1.5	-1.0	-0.5	-0.5	-0.2	-0.1	0.0	0.0	-0.2	0.9	0.1
Alzheimer’s Disease (in father)	0.5	0.5	3.6	0.2	-0.4	-0.5	-1.9	-0.6	0.2	-0.5	0.3	0.8	-0.6	0.5	0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	-0.1	-0.7	-0.7	-1.1	-0.1	-1.1	-0.1	-0.7	-0.0	-1.0	0.7	-0.7
Crohns Disease (2017)	0.6	1.2	4.5	1.8	0.0	-1.2	0.4	-0.1	-0.6	1.3	-0.1	-1.1	-2.1	-0.4	-1.3
Irritable Bowel Disease (IBD)	0.6	1.3	4.9	1.6	0.9	0.1	1.0	0.8	-0.9	2.2	-0.3	-0.6	-1.8	0.5	-1.0
Ulcerative Colitis (UC)	0.5	0.9	3.4	0.7	1.3	1.0	0.7	1.1	-1.0	1.8	-0.5	0.1	-0.6	0.8	-0.3
Major Depression (MDD)	0.5	0.6	4.2	-1.1	0.1	0.1	0.2	0.0	0.6	2.1	0.4	0.0	0.0	-0.8	-0.6
Reaction Time	0.8	1.6	5.2	0.5	1.5	1.5	1.6	1.5	-0.5	2.3	-0.3	-0.8	-1.1	-1.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.5	-0.4	0.6	-0.2	-0.9	-0.0	-0.5	0.3	-0.8	0.0	1.2	0.3	0.8
Breast Cancer	0.9	2.2	6.1	-1.6	-0.2	0.2	-0.8	0.1	1.4	-1.0	1.3	2.4	1.9	2.5	1.8
Ovarian Cancer	0.5	0.7	4.7	-2.2	0.8	1.0	0.6	0.2	0.8	0.4	0.7	0.5	-0.0	0.6	-0.1
Prostate Cancer	0.3	0.4	1.7	-0.6	-0.4	0.2	0.3	0.0	0.7	-0.7	0.5	0.7	1.3	-0.5	0.8
Age at First Birth	0.8	1.2	5.3	-1.0	-0.5	0.1	-0.8	-0.5	1.3	0.7	1.1	0.9	1.0	2.3	1.5
Bipolar Disorder (2011)	1.5	1.4	7.6	-0.3	0.0	-1.6	0.0	-2.1	1.5	2.8	0.0	0.0	0.5	0.5	0.2
Body Mass Index (BMI) (2010)	1.1	1.5	2.6	-0.9	-1.4	-0.4	-0.9	-1.2	1.3	1.1	1.6	1.4	1.5	0.6	1.6
Coronary Artery Disease (CAD)	0.8	0.9	3.2	0.9	1.4	1.8	0.2	1.1	-0.3	-1.5	-0.1	0.0	1.1	-0.0	0.2
Crohns Disease (2012)	0.4	0.7	2.2	1.5	-0.2	-1.5	0.2	-0.2	0.7	0.5	0.8	0.0	-1.3	0.3	-0.9
Mean Putamen Volume	0.3	0.4	1.2	-0.7	-0.7	-0.4	-0.5	0.1	0.8	0.1	0.9	0.5	1.1	-0.2	0.7
Fasting Glucose	1.5	1.8	4.7	1.3	-2.2	-2.0	-1.8	-1.3	0.1	-0.1	-0.3	1.0	0.5	1.9	0.8
HbA1C	0.8	0.9	3.7	-1.0	1.1	1.0	0.5	0.8	0.3	0.5	-0.0	0.3	-0.4	-1.6	1.9
HDL Cholesterol	0.3	0.5	1.5	-0.9	-0.2	0.2	-0.4	-0.3	1.0	0.6	0.9	0.7	0.9	-0.1	1.2
LDL Cholesterol	0.5	0.8	2.6	0.1	-0.3	-1.1	-0.5	-0.8	-1.6	-0.6	-1.5	-0.5	-0.7	0.5	-0.7
Lupus	0.3	0.5	1.8	-1.3	-0.6	-0.6	1.4	-0.5	0.6	-0.3	0.7	0.0	0.5	-0.1	0.0
Neuroticism (2016)	1.0	1.4	4.5	0.6	0.5	0.4	0.7	0.4	-0.8	1.6	-0.9	-1.6	-1.6	-1.2	-2.1
Primary Biliary Cirrhosis	1.9	2.7	6.3	-0.1	-2.5	-2.2	-1.8	-2.0	1.9	0.3	1.6	0.0	1.5	0.8	2.1
Rheumatoid Arthritis	0.4	0.6	2.1	-1.3	0.6	0.4	0.7	0.4	0.5	0.8	0.2	0.0	-0.7	-1.5	-0.8
Schizophrenia (2014)	0.5	1.1	3.8	0.9	1.7	1.6	0.8	1.4	-0.3	1.9	-0.6	0.0	-0.5	0.0	-0.3
Triglycerides	0.4	0.7	4.2	0.5	0.5	0.1	1.1	0.7	-2.0	0.1	-1.0	-0.5	-0.2	0.2	-0.9
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.9	-0.6	-1.6	-0.8	-1.7	-1.6	0.5	-0.4	0.2	0.0	0.3	0.2	1.1
Ulcerative Colitis	0.5	0.8	2.9	1.2	1.1	0.5	0.9	1.2	-0.5	1.7	-0.6	0.0	-0.4	0.4	-0.5
Blood Eosinophil Count	0.1	0.9	6.1	-0.0	-0.7	-1.6	0.1	-0.9	0.7	-2.5	0.3	-0.2	0.3	-0.2	0.6
Blood Platelet Count	0.2	1.8	7.4	-2.0	-0.6	-0.5	-1.4	-0.4	-0.7	-0.6	0.8	1.7	2.7	1.5	0.9
Blood Red Count	0.1	1.1	2.8	-1.2	-1.3	-1.1	-1.1	-1.6	1.1	1.7	0.5	0.1	-0.6	-0.3	0.1
Blood White Count	0.8	6.2	29.7	-0.4	-0.1	0.1	1.2	0.2	4.6	0.6	5.5	2.8	3.0	0.1	2.3
Heel T-Score	0.6	5.0	17.2	0.4	-0.4	-2.0	-0.2	-0.5	-3.1	1.5	-3.1	-2.8	-4.2	-0.1	-2.9
BMI	1.8	10.2	25.0	-1.3	-5.0	-3.0	-4.8	-4.5	1.9	1.9	2.2	3.4	1.5	2.8	3.2
Height	0.2	3.0	12.8	-0.4	1.7	0.1	1.7	1.2	-0.1	-1.2	0.3	-3.6	-1.5	-1.6	-3.1
Waist Hip Ratio (WHR)	0.3	1.4	3.3	0.7	1.5	0.4	1.4	0.9	-1.7	-1.8	-1.1	-1.0	-1.0	-0.3	-1.4
Systolic Blood Pressure	0.5	2.3	12.3	2.7	-0.1	-1.2	0.8	-1.1	-0.1	-3.5	0.3	-0.8	1.8	-0.9	-0.3
Smoking Status	0.3	0.7	3.7	-1.1	0.6	0.2	1.9	0.5	0.4	0.7	1.1	0.3	0.0	0.0	-0.5
Allergy or Eczema	0.5	1.3	5.9	0.1	1.5	1.7	0.1	2.4	0.6	0.3	0.4	0.9	0.2	-1.5	0.9
Cardiovascular Disease	0.6	1.9	6.9	1.8	-1.4	-1.6	-1.0	-1.8	-1.8	-2.6	-0.9	-0.3	0.1	0.6	-0.1
Hypothyroidism (self reported)	0.5	1.1	2.8	0.8	1.3	1.4	1.7	0.8	-1.3	-0.4	-0.9	-0.4	-0.7	0.6	-1.1
Respiratory disease	0.4	0.9	2.0	0.3	-1.3	-1.3	-0.8	-0.5	1.3	-0.1	1.4	0.8	0.2	0.9	0.9
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.1	1.5	-1.1	-1.5	-2.0	-1.7	1.5	-0.8	1.3	1.5	1.1	0.7	1.6
Lung FEV1/FVC ratio	0.1	0.6	2.0	0.3	1.0	1.2	-0.6	0.6	-0.4	-1.4	-0.2	0.8	0.6	0.5	0.2
Lung FVC	0.5	2.4	11.0	-0.3	-0.3	0.8	-0.3	0.3	1.2	-1.7	1.0	2.1	3.3	0.1	2.6
Neuroticism	0.8	1.8	3.6	0.6	0.9	0.7	1.5	1.5	-1.7	0.1	-1.6	-1.9	-1.7	-0.8	-1.9
Chronotype (morning person)	1.6	3.6	14.1	0.7	-3.0	-3.8	-1.3	-3.3	-0.3	0.1	-0.3	-0.5	-0.9	1.7	-1.8
Hair Pigment	0.2	5.1	23.6	-3.0	0.3	-1.7	1.2	0.4	-1.0	4.9	-1.4	-1.8	-2.6	-0.5	-3.3
Tanning	0.1	0.7	4.1	-0.4	-0.3	0.5	0.4	-0.3	-1.3	-0.7	-0.2	-0.5	-1.2	0.1	-2.0
Hand grip strength (left)	0.3	0.9	3.0	0.9	-0.2	-1.0	-0.3	-0.6	-0.1	-0.4	0.1	-1.4	-0.9	-1.7	-1.5
Number of treatments/medications taken	0.2	0.4	2.1	-0.9	-0.2	-0.3	-0.3	-0.4	-0.6	-0.2	-0.5	0.3	-0.6	1.4	-0.2
Average weekly spirits intake	1.2	1.5	3.4	-1.3	-1.1	-0.6	-0.7	-1.3	1.2	1.2	1.3	1.8	0.7	1.8	0.8
Sensitivity / hurt feelings	0.6	1.0	3.8	-0.3	0.3	-0.4	0.2	0.5	-0.9	0.0	-1.2	-1.6	-2.0	-1.0	-1.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.6	-1.0	1.2	1.3	1.1	1.6	1.2	0.3	1.1	-0.2	-0.4	-0.9	-0.6
Hearing difficulty/problems: Yes	1.8	2.7	9.3	-1.1	-0.6	-1.6	-0.4	-0.5	-2.3	1.6	-1.7	-1.1	-3.0	1.1	-2.4
Relative age of first facial hair	0.2	0.4	1.3	-0.4	-0.7	-0.7	-0.7	-0.4	0.8	0.3	0.6	0.5	1.2	0.5	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	-1.6	-0.1	0.5	-0.2	0.2	0.5	-1.0	0.9	1.4	1.0	0.8	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	-1.1	0.3	0.8	0.5	0.5	0.9	0.4	1.4	-0.0	0.1	-0.0	-0.8
Ever had hysterectomy (womb removed)	0.5	0.5	1.6	-0.7	-1.2	-1.2	-0.1	-1.1	0.1	-0.3	0.4	-0.3	-0.6	0.5	-0.9
Systolic blood pressure, automated reading	0.5	1.4	4.7	0.2	-1.4	-1.9	-0.0	-2.1	0.5	-2.2	0.4	-0.1	1.0	0.7	0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.4	0.2	0.6	0.4	-0.1	0.5	-0.7	0.5	0.0	-0.5	-0.2	-0.5
Angina	0.5	0.7	2.3	0.3	-0.5	0.0	-0.8	-0.4	-1.2	-1.5	-1.4	-0.2	-0.4	0.8	0.4
Medication for hormone replacement therapy	0.8	0.9	2.4	-0.4	1.5	0.8	0.9	1.5	-0.6	1.3	0.1	-0.4	0.1	-0.5	-1.5
Vitamin and mineral supplements	0.4	0.5	3.1	1.7	-0.4	0.2	-0.7	-0.8	-0.6	0.1	0.1	0.6	0.1	1.1	0.3
Supplements: Zinc	0.8	0.8	3.7	-1.1	-1.2	-1.0	-1.9	-1.3	0.1	-0.4	0.2	0.4	0.5	-0.8	0.2
Medication: Co-codamol	0.4	0.4	2.7	1.6	0.3	0.2	0.1	0.4	0.8	-0.2	1.1	-0.1	-0.1	-0.2	-0.2
Medication: Metformin	1.8	2.5	7.7	1.1	-1.9	-1.8	-2.8	-2.2	1.0	-0.9	0.5	1.7	1.1	1.1	1.4
Diabetes (father)	0.5	0.6	1.7	0.6	-0.5	-0.2	-1.1	-0.8	1.3	-1.1	1.1	0.2	0.4	-0.7	0.6
Diabetes (mother)	0.8	1.1	4.9	1.7	0.7	0.7	0.6	1.2	1.1	2.2	0.3	-0.1	-0.6	0.3	0.4
Severe depression (siblings)	0.9	1.0	3.0	-1.7	-1.0	0.1	-1.0	0.3	0.6	0.7	1.3	1.0	1.0	0.4	1.4
Pack years adult smoking proportion	0.9	1.4	3.4	-0.3	-1.0	-0.3	-1.2	-0.8	1.8	-0.3	1.8	1.7	1.0	-0.3	1.5
Impedance of leg (right)	0.8	4.1	10.5	0.7	3.0	1.6	3.1	2.0	0.1	-1.7	-0.8	-2.2	-0.4	-3.2	-2.0
Leg fat-free mass (left)	0.9	4.7	10.4	-1.2	-3.2	-2.1	-3.1	-2.2	1.3	2.3	2.1	1.7	0.7	2.9	1.7
Trunk fat percentage	0.9	3.5	11.1	-2.5	-2.0	-0.5	-1.3	-1.9	1.9	3.3	2.0	1.9	0.3	0.9	1.5
Hand grip strength (right)	0.2	0.6	2.8	1.7	0.4	-0.5	0.1	-0.1	0.3	-0.3	0.3	-1.1	-0.5	-1.3	-0.7
Townsend deprivation index at recruitment	0.9	1.3	8.4	-2.9	0.2	0.6	0.3	-0.3	0.4	1.0	1.2	1.6	0.0	0.9	0.5
Current tobacco smoking	0.4	0.7	2.3	0.0	0.3	0.3	1.0	0.2	1.4	0.3	1.5	1.0	1.0	-0.4	0.7
Average weekly fortified wine intake	2.3	2.7	5.4	2.1	2.1	0.6	2.0	1.6	-1.6	-0.5	-1.4	-2.0	-1.5	-0.8	-2.3
Maternal smoking around birth	1.0	1.5	3.9	-2.0	-1.7	-0.2	-1.2	-1.3	1.0	-0.2	1.1	1.6	0.4	1.2	1.2
Fed-up feelings	0.4	0.7	2.3	0.8	0.6	1.5	0.4	1.0	0.5	-0.4	0.8	1.3	1.0	0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.3	-1.4	0.1	0.9	1.0	1.0	1.2	-0.4	1.1	-0.1	-0.2	-1.5	-0.1
Relative age voice broke	0.1	0.2	0.8	0.9	0.4	-0.4	0.2	0.4	-0.5	0.2	-0.6	-0.5	-0.1	-0.0	-0.5
Taking other prescription medications	0.4	0.6	1.6	-1.2	1.0	0.9	1.3	1.2	-0.3	-0.5	0.5	0.7	0.2	-0.4	0.1
Age when periods started (menarche)	0.6	1.4	5.2	-0.7	-0.2	-0.2	-0.4	-0.2	2.3	-0.4	2.3	1.2	1.3	0.7	1.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.8	1.3	-0.0	-0.0	0.0	0.1	-0.0	-0.0	0.8	0.5	0.6	0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.4	-0.8	1.3	1.4	1.5	1.4	-1.5	1.8	-1.7	-0.7	-1.8	-1.1	-0.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	5.1	-0.5	0.7	1.5	0.2	0.6	0.6	-1.2	0.6	1.9	2.1	0.7	2.2
Qualifications: CSEs or equivalent	0.9	1.2	3.9	0.5	0.6	1.7	0.6	0.9	2.0	-0.7	1.9	0.7	0.0	-1.0	0.8
Serious illness, injury or assault to yourself	1.4	1.7	4.6	-2.1	-1.5	-0.9	-2.1	-1.3	0.3	-0.9	-0.1	1.0	0.2	1.3	1.9
High blood pressure	0.7	2.0	4.3	1.9	-1.0	-1.6	-0.2	-1.9	-1.3	-2.1	-0.8	-1.7	-1.5	0.1	-1.4
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.6	-0.4	1.8	2.1	0.5	2.6	1.4	0.6	1.5	1.1	1.0	-2.0	1.6
Multivitamins +/- minerals	0.8	1.0	11.3	-3.4	-0.4	-0.5	0.1	-0.2	0.3	0.0	-0.0	-0.5	0.0	-0.1	-0.4
Stomach or abdominal pain in last month	2.1	2.7	6.8	-0.4	0.8	1.6	0.9	0.9	2.2	-0.8	2.4	2.1	2.0	-0.8	2.6
Supplements: Glucosamine	0.9	1.2	3.1	-1.8	-0.9	-1.3	-1.1	-1.1	-1.0	-1.4	-0.8	-0.8	-1.1	-0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	8.6	1.7	2.5	2.3	2.9	2.6	-0.8	-0.5	-0.4	-0.3	-0.1	-1.4	-0.6
Medication: Atenolol	0.5	0.6	2.8	0.7	-0.2	-0.2	-0.6	-0.0	-1.7	0.4	-1.6	0.0	-0.2	1.0	0.4
Medication: Levothyroxine sodium	1.9	3.2	10.2	0.7	2.3	2.6	3.2	2.6	-1.5	0.6	-1.1	-1.0	-0.7	-1.4	-1.4
Sitting height	0.3	1.8	8.7	0.5	1.6	0.1	1.4	1.5	-0.4	-0.8	-0.4	-3.0	-0.6	-0.6	-2.1
Chronic bronchitis/emphysema (father)	0.9	1.1	4.3	-2.1	0.4	0.8	0.7	0.7	-0.8	1.4	-1.1	-0.8	-1.4	-0.0	-0.6
High blood pressure (mother)	0.4	0.5	3.9	0.5	-0.1	0.1	0.1	0.8	-0.9	-2.0	-0.5	-0.0	0.5	0.3	0.5
Body mass index (BMI)	1.3	5.7	14.1	-1.7	-3.8	-1.9	-2.9	-3.1	1.6	2.7	2.3	2.4	0.3	2.1	2.0
Impedance of leg (left)	1.0	5.0	13.6	0.6	3.3	1.9	3.7	2.3	0.2	-1.7	-0.9	-2.2	-0.4	-3.7	-2.2
Leg predicted mass (left)	0.9	4.6	10.1	-1.1	-3.2	-2.1	-3.0	-2.2	1.4	2.3	2.2	1.7	0.7	2.8	1.7
Trunk fat mass	1.0	4.3	9.6	-2.5	-2.7	-1.3	-1.9	-2.4	2.0	3.1	2.3	1.8	0.3	1.5	1.5
Waist circumference	0.7	2.7	7.7	-1.8	-2.8	-2.0	-1.8	-2.4	0.5	1.6	1.1	0.7	-1.1	1.7	0.2
Number of incorrect matches in round	2.6	4.3	12.0	0.2	1.5	0.4	1.6	1.4	-1.4	0.4	-2.0	-3.4	-3.5	-1.7	-3.4
Past tobacco smoking	0.4	0.8	7.5	2.7	0.1	0.2	-0.5	0.4	0.7	-0.4	-0.0	-0.1	0.6	-0.1	0.6
Alcohol usually taken with meals	0.7	1.1	5.2	-2.3	1.1	0.6	0.3	0.7	-1.2	0.1	-1.7	-1.0	-0.5	0.3	0.8
Nervous feelings	0.5	0.9	3.2	1.8	0.9	0.6	0.4	1.4	-0.9	0.4	-1.1	-1.1	-0.6	0.3	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	4.3	-1.6	1.1	2.1	1.3	1.7	0.2	-0.9	-0.3	0.5	0.1	-1.1	0.3
Hearing difficulty/problems with background noise	1.3	2.1	6.7	-0.8	-0.9	-2.0	-1.2	-1.2	-1.9	0.2	-1.5	-0.5	-2.6	0.9	-1.8
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	0.2	-0.1	0.7	0.1	-0.2	0.4	-0.1	0.5	1.0	0.7	0.2	0.6
Had menopause	1.0	1.2	4.3	-0.4	0.8	0.5	1.3	0.9	-0.8	-0.2	-1.0	-1.6	-0.9	-2.1	-1.5
Had other major operations	0.9	1.2	2.6	-1.1	-1.3	-0.8	-1.6	-1.3	0.9	-0.6	0.9	0.9	1.0	-0.2	1.5
Forced vital capacity (FVC)	0.4	1.4	4.9	0.7	1.3	1.6	0.2	1.4	1.1	-1.3	0.7	0.7	2.2	-0.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.6	-0.4	0.6	1.3	1.2	1.0	-1.2	1.4	-1.5	-0.8	-1.9	-0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.3	-0.8	-1.0	-1.0	-0.4	0.2	0.8	0.4	0.6	-0.4	-0.4	-0.5
Qualifications: None of the above	1.2	2.6	8.4	-0.2	-2.3	-2.0	-1.1	-2.9	-0.1	0.8	0.2	-0.0	-1.3	2.3	-2.1
Financial difficulties in last 2 years	0.2	0.3	1.2	0.1	1.1	0.5	0.4	0.8	-0.3	0.0	0.1	0.5	-0.2	0.4	0.4
Mouth/teeth dental problems	0.3	0.5	1.9	0.3	0.8	0.6	0.5	0.7	0.9	0.8	0.7	0.2	1.4	-0.6	0.5
Heart attack	0.3	0.3	1.3	-1.1	0.1	0.3	0.6	-0.0	-0.7	-0.5	-0.5	-0.3	-0.9	0.6	0.2
Allergy	0.5	1.2	4.1	-0.0	-0.4	-0.4	0.1	-1.3	-1.7	0.4	-2.0	-1.0	-0.9	1.2	-1.4
Pain all over the body in last month	0.7	0.8	2.3	0.7	0.8	1.0	-0.8	1.5	0.3	0.1	0.2	0.7	1.4	0.5	1.3
Diabetes (self-reported)	0.4	0.6	1.7	1.3	-0.2	-0.1	-0.8	-0.4	1.0	-0.5	0.8	1.0	0.6	0.6	1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.8	0.2	1.6	0.9	1.1	1.7	0.4	0.9	0.4	-0.7	-0.7	-0.6	-0.5
Medication: Ramipril	0.7	0.9	2.6	-1.6	-1.0	-0.9	-1.1	-1.2	-1.0	0.2	-0.8	0.3	-0.8	1.1	-0.4
Medication: Simvastatin	0.6	0.9	3.1	-0.5	-0.9	-0.7	-0.9	-1.1	-1.6	0.1	-1.3	0.2	-0.5	1.8	-0.0
Fluid intelligence score	0.2	0.4	1.8	-1.3	0.3	-0.8	-1.0	-0.5	-0.3	0.7	-0.6	-0.4	0.4	0.4	0.5
Illnesses of siblings	0.6	0.9	2.0	0.3	1.3	1.3	0.7	1.2	0.9	-0.8	0.6	0.9	0.8	-0.2	1.4
Neuroticism score	0.7	1.4	3.6	0.2	1.5	1.1	1.7	1.9	-1.1	-0.1	-1.0	-1.2	-1.1	-1.1	-1.1
Weight	0.9	4.4	11.6	-1.8	-3.4	-2.3	-2.6	-2.7	1.3	2.5	1.9	1.2	-0.0	2.1	1.0
Impedance of arm (right)	0.9	4.0	15.8	-0.3	4.0	3.3	2.9	2.7	0.0	1.0	-0.6	-0.4	0.1	-2.0	-0.4
Arm fat percentage (right)	1.4	5.5	12.7	-2.4	-2.7	-0.9	-2.4	-2.5	1.8	3.6	2.3	2.9	0.8	1.9	2.4
Trunk fat-free mass	0.5	3.0	10.2	-0.1	-3.0	-3.2	-2.3	-2.1	-0.1	0.5	0.9	-0.4	-0.5	2.3	-0.6
Hip circumference	0.9	3.9	9.9	-1.6	-3.1	-2.0	-2.4	-2.5	1.3	3.1	1.7	0.9	-0.7	1.6	0.8
Time employed in main current job	0.8	1.0	3.9	2.0	-0.5	-0.5	-1.2	-0.6	-1.2	0.4	-1.5	-0.0	-0.2	-0.4	-1.1
Alcohol intake versus 10 years previously	0.5	0.8	2.3	-1.1	-0.5	-0.8	-1.5	-0.9	-0.8	-1.5	-1.1	0.2	0.4	-0.2	-0.1
Father’s age at death	0.6	0.7	3.1	-0.1	0.6	-0.9	1.4	0.2	0.4	0.9	0.8	-0.8	-0.7	0.1	-1.8
Worrier / anxious feelings	0.6	1.2	3.6	0.5	0.1	-0.8	1.0	0.2	-0.9	-0.4	-1.1	-1.8	-1.6	-0.7	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.9	-0.2	1.0	1.7	0.9	1.3	0.1	0.0	0.2	0.7	-0.3	-1.2	-0.4
Falls in the last year	0.9	1.2	4.1	0.1	-0.9	-0.2	-1.4	-0.7	0.9	-0.1	0.6	1.6	1.7	0.2	2.0
Hair/balding pattern: Pattern 3	0.9	1.4	5.9	0.4	-1.7	-2.4	-1.3	-1.2	-1.4	-0.7	-1.0	-0.6	-0.3	-0.1	-0.4
Number of live births	0.4	0.5	1.9	0.6	0.4	0.7	0.7	-0.1	-1.2	-0.2	-0.7	-0.4	-1.4	0.5	-0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	6.4	0.8	2.0	2.5	0.2	1.8	0.8	-1.4	0.6	1.1	2.4	-0.2	1.4
Pulse rate	0.5	0.8	1.9	-1.3	-0.7	0.1	-0.4	-0.6	1.4	-0.5	1.4	0.6	0.5	-1.3	1.0
Happiness	1.2	1.5	4.6	1.0	0.1	-0.8	-0.5	0.1	-1.9	1.1	-2.2	-1.4	-1.6	0.5	-1.4
Noisy workplace	0.2	0.2	0.7	0.1	-0.3	-0.1	0.5	0.4	-0.6	-0.4	-0.4	-0.2	-0.6	-0.8	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.7	-0.1	2.2	1.2	1.2	1.7	0.7	1.1	0.2	-0.4	0.4	-0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.1	-0.9	-0.3	0.9	-0.5	-0.6	2.0	-0.3	2.0	1.9	1.3	-0.3	1.1
Mouth/teeth dental problems: Dentures	1.1	1.9	5.0	-1.4	-1.4	-1.4	-0.4	-1.2	-1.0	-0.1	-0.5	-1.7	-2.2	1.2	-2.1
Asthma	0.8	1.5	3.1	-0.4	-1.7	-1.6	-1.3	-1.0	1.7	-0.3	1.8	1.2	0.7	0.8	1.2
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	6.0	-2.0	-0.8	-0.3	-1.8	-1.1	1.8	0.4	1.7	2.5	1.6	1.9	2.0
Medication: Cholesterol lowering	0.9	1.4	4.5	-1.2	0.2	-0.4	0.1	-0.4	-1.9	-0.3	-1.9	-1.1	-2.1	0.2	-1.4
Depression (self-reported)	1.9	2.3	7.5	0.5	2.1	2.0	2.5	2.7	-0.2	0.9	-0.5	0.5	-0.4	-1.9	0.0
Medication: Lansoprazole	0.4	0.4	1.3	-0.4	-0.1	0.4	0.0	0.6	0.9	-0.7	1.1	1.1	0.4	0.4	0.3
Prospective memory result	0.7	0.9	3.3	0.7	0.4	0.6	1.3	0.8	0.3	0.4	0.4	-0.9	-1.8	-1.0	-1.4
Lung cancer (father)	0.4	0.5	1.8	-0.7	-1.2	-0.4	-1.3	-0.6	-0.1	-0.1	-0.0	0.0	0.4	1.0	0.7
Illnesses of mother	0.2	0.2	0.6	-0.3	0.7	0.0	0.4	-0.5	0.3	-0.3	0.1	0.1	0.6	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.9	1.3	1.9	2.4	1.0	1.9	0.1	-1.3	0.2	0.0	1.5	-0.5	0.5
Pulse wave Arterial Stiffness index	0.5	0.5	1.0	-0.9	-0.9	-0.5	-0.3	-0.9	-0.7	-0.5	-0.3	-1.0	-1.0	-0.6	-0.8
Impedance of arm (left)	0.9	4.4	15.3	-0.8	3.9	3.6	3.1	2.9	0.3	1.0	-0.6	-0.4	0.1	-2.0	-0.1
Arm fat mass (right)	1.3	5.4	10.7	-2.3	-3.3	-1.6	-2.7	-2.7	1.7	3.0	2.4	2.3	0.6	2.1	2.0
Trunk predicted mass	0.5	3.0	10.3	-0.0	-3.0	-3.2	-2.3	-2.1	-0.1	0.5	0.9	-0.5	-0.5	2.3	-0.7
Standing height	0.1	1.3	6.7	-0.5	0.4	-1.1	0.5	0.4	-0.6	-0.1	-0.6	-2.6	-1.0	0.2	-2.2
Length of working week for main job	1.8	2.0	8.2	0.4	-2.0	-2.9	-1.4	-2.3	0.0	1.6	0.5	-0.1	-1.1	0.7	-0.6
Exposure to tobacco smoke at home	0.7	0.8	2.3	-1.5	-1.2	-0.8	-1.2	-1.4	0.4	0.4	0.3	0.9	-0.6	0.3	-0.0
Breastfed as a baby	0.2	0.2	0.9	-0.9	-0.4	-0.6	-0.7	-0.7	-0.2	0.1	-0.1	-0.3	0.1	0.6	-0.4
Tense / ‘highly strung’	0.8	1.4	4.1	-0.1	0.7	0.1	2.0	1.6	-0.9	-0.1	-0.9	-1.8	-1.1	-0.5	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.2	-0.6	1.1	0.9	1.8	1.4	0.3	1.7	0.9	-0.4	-1.2	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.4	0.9	2.8	1.1	0.9	0.6	0.4	0.1	1.0	1.3	-0.1	-0.3	-1.4	0.0	-1.7
Birth weight of first child	0.6	1.2	2.8	-0.5	-1.4	-1.0	-1.5	-1.6	-1.1	1.1	-0.8	0.2	0.2	1.7	-0.2
Peak expiratory flow (PEF)	0.3	0.7	1.7	-0.1	1.3	1.2	0.2	1.2	-0.6	-1.1	-0.6	-0.3	1.1	0.4	0.0
Pulse wave reflection index	0.2	0.3	0.9	-0.9	0.0	0.2	1.0	-0.3	-0.1	-0.3	0.5	-0.5	-0.7	0.2	-0.5
Ever highly irritable/argumentative for 2 days	0.8	0.9	5.4	1.3	0.8	0.8	-0.0	0.6	-0.4	2.3	0.3	0.3	0.2	1.1	-0.9
Loud music exposure frequency	0.7	0.7	3.3	-1.4	0.2	0.9	-0.3	-0.0	0.9	-0.3	0.5	1.8	0.6	0.3	1.0
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	6.5	-0.5	0.7	1.0	0.8	0.8	2.5	0.5	2.5	0.7	1.9	-1.0	2.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.5	-0.7	-0.8	-0.6	-1.1	-0.5	-0.9	0.1	-0.9	0.8	0.2	1.6	0.9
Blood clot in the leg (DVT)	0.4	0.6	1.5	0.8	-0.5	-0.4	-0.9	-0.8	0.5	-1.2	1.0	-0.0	-0.6	0.4	-1.1
Medication: Paracetamol	0.9	1.5	6.2	-1.3	-1.0	-0.6	-0.2	-0.8	2.2	0.5	2.5	1.3	0.3	-0.4	1.1
Headache pain in last month	0.7	1.2	3.7	-0.2	1.8	1.0	1.9	1.4	1.2	-1.4	0.9	0.4	0.1	-0.2	0.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.3	-0.0	0.5	1.0	0.1	1.1	2.5	-0.1	1.9	1.4	2.1	-0.5	1.5
Glaucoma (self-reported)	1.4	1.7	3.5	-1.2	-1.0	-1.2	-1.1	-0.5	-1.7	1.9	-1.8	-0.8	-1.1	1.2	-1.5
Gout (self-reported)	1.8	2.4	7.0	0.2	1.4	0.8	0.6	0.5	-2.7	1.4	-2.3	-1.5	-2.0	-0.6	-2.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	4.9	1.0	1.7	1.9	2.2	1.8	-2.1	0.1	-1.5	-1.1	-0.9	-0.4	-1.8
Medication: Amlodipine	1.4	1.9	4.8	2.2	-1.6	-2.0	-0.1	-1.0	-1.6	0.6	-1.5	-1.8	-1.1	0.7	-0.8
Medication: Ventolin 100micrograms inhaler	2.3	2.9	6.9	-1.8	-2.2	-1.6	-1.6	-1.7	1.3	-2.6	1.7	1.3	1.6	0.5	1.7
Birth weight	0.5	1.1	4.8	0.1	-1.5	-1.5	-2.2	-1.2	0.0	0.4	0.0	0.2	-0.3	1.5	-0.3
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.1	-1.5	-2.0	-0.8	-1.5	-1.5	1.6	-0.2	1.7	1.8	1.4	0.3	1.9
High blood pressure (siblings)	1.2	1.8	6.2	0.4	-2.5	-2.4	-1.6	-2.3	0.3	-0.6	0.5	-0.3	0.7	-0.2	0.0
Forced vital capacity (FVC), Best measure	0.3	1.3	3.0	1.5	1.5	1.7	1.0	1.6	0.1	-1.2	0.1	-0.2	1.5	-0.5	0.3
Body fat percentage	1.0	3.8	10.4	-2.3	-2.4	-0.8	-1.5	-2.2	2.0	3.2	2.2	2.1	0.2	1.0	1.6
Leg fat percentage (right)	1.0	3.5	9.1	-1.5	-3.0	-1.7	-2.0	-2.8	1.9	2.0	2.0	1.5	-0.1	0.8	1.1
Arm fat-free mass (right)	0.7	3.4	12.6	-0.5	-3.5	-3.0	-2.4	-2.3	0.9	0.4	1.6	0.1	0.2	2.0	0.3
Exposure to tobacco smoke outside home	0.9	1.1	4.4	-2.1	-0.6	0.3	-0.8	-0.7	1.6	0.3	1.3	1.1	0.5	-0.3	1.3
Comparative body size at age 10	0.2	0.6	2.1	0.8	-1.2	-0.5	-1.5	-1.1	-0.7	0.4	-0.3	0.9	0.0	0.1	0.1
Number of full brothers	1.5	1.9	4.0	-0.9	-1.1	0.2	-1.5	-1.5	1.7	0.1	1.9	2.0	1.4	1.3	1.5
Worry too long after embarrassment	1.2	2.0	4.6	-2.1	1.8	1.3	1.3	1.1	-2.2	0.2	-2.1	-1.0	-1.1	-0.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	4.5	-0.3	-0.1	-0.7	1.1	0.2	-1.6	0.7	-1.1	-0.8	-1.8	0.5	-2.1
Wheeze or whistling in the chest in last year	1.7	3.1	8.8	-1.2	-0.5	1.1	-0.1	0.3	2.5	-1.4	3.0	2.3	2.4	-0.8	2.4
Number of children fathered	2.2	2.5	8.0	0.8	-2.3	-2.8	-2.4	-2.8	0.2	-1.2	0.2	0.3	-0.1	1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	5.1	-0.8	1.4	0.8	1.3	0.9	-2.3	-1.2	-2.2	-0.7	-0.6	-0.4	-0.6
Age at first live birth	0.5	0.8	2.4	1.5	0.6	0.5	0.2	0.6	-0.6	-0.3	-1.5	0.4	1.5	0.8	1.0
Pulse wave peak to peak time	0.3	0.4	1.0	1.0	0.9	0.4	0.3	0.9	0.5	0.5	0.0	0.7	0.7	0.7	0.5
Health satisfaction	1.2	1.6	3.3	-1.6	-1.3	-0.8	-1.6	-1.7	0.7	-0.6	0.7	1.8	0.8	1.6	1.0
Shortness of breath walking on level ground	0.6	0.7	1.7	-0.7	-0.5	0.0	-0.2	-0.6	1.3	0.2	1.3	1.0	1.2	-0.1	1.0
Qualifications: College or University degree	0.8	2.4	6.1	1.5	2.2	0.6	1.0	1.5	-2.0	1.6	-2.5	-1.3	-1.6	-0.3	-1.4
Eye problems/disorders: None of the above	0.7	0.8	2.6	0.6	0.6	0.6	0.8	1.1	0.6	-0.7	0.6	0.2	1.6	-1.3	1.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.9	0.8	1.7	1.5	1.1	1.7	-0.9	1.0	-0.3	-0.4	-1.3	-1.1	-0.8
Emphysema/chronic bronchitis	0.2	0.2	1.0	-0.6	0.1	0.3	0.3	0.6	-0.1	-1.0	-0.5	-0.4	-0.3	0.5	0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	4.2	2.0	0.2	-0.2	0.2	0.8	-0.6	-0.0	-1.2	-1.5	0.4	-1.5	-0.4
Neck or shoulder pain in last month	1.7	2.4	6.0	-2.4	-1.5	-0.8	-1.0	-1.5	1.8	-2.4	1.8	1.4	0.9	-0.0	1.2
Medication: Blood pressure	0.8	1.3	5.7	1.5	0.3	0.0	0.4	-0.3	-2.4	-0.8	-2.0	-1.2	-1.1	0.0	-0.6
Angina (self-reported)	0.5	0.6	2.3	0.1	-0.2	0.3	-0.4	0.0	-1.4	-1.4	-1.5	-0.4	-0.5	0.6	0.3
Migraine (self-reported)	1.1	1.4	6.8	0.3	-1.3	-0.9	-0.1	-0.5	2.2	-0.2	2.6	0.5	1.1	-0.2	0.9
Medication: Ibuprofen	2.0	2.4	6.1	-1.5	-0.5	0.2	-1.5	-0.9	1.9	0.7	1.7	2.5	1.5	1.7	2.1
Medication: Allopurinol	0.8	1.0	1.8	0.2	1.3	1.4	0.8	1.1	-1.2	0.4	-1.0	-0.4	-1.1	-1.2	-1.2
Medication: Omeprazole	0.7	0.8	4.4	-1.8	-0.2	0.2	0.3	-0.2	-0.0	-2.1	0.1	0.8	0.6	1.0	0.0
Medication: Seretide 50 evohaler	0.9	1.1	3.4	0.3	-0.6	0.1	-1.1	-0.5	0.4	1.5	0.2	1.8	1.2	0.7	1.8
Mean time to correctly identify matches	0.5	1.0	4.1	0.4	0.0	-0.2	0.3	-0.0	-1.1	2.0	-0.7	-1.1	-1.5	-0.6	-1.4
Heart disease (mother)	0.5	0.6	1.5	1.2	-0.3	-0.1	-0.2	0.7	-1.1	-1.2	-0.9	-1.0	-0.5	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	3.2	-1.8	0.7	1.1	0.3	0.5	-0.2	-0.8	0.0	-0.4	-0.2	0.5	-0.3
Whole body fat mass	1.1	4.5	9.9	-2.4	-2.8	-1.4	-2.1	-2.4	1.9	3.1	2.3	1.9	0.3	1.7	1.6
Leg fat mass (right)	1.4	5.6	13.3	-2.1	-3.6	-2.1	-2.6	-3.0	2.3	2.3	2.7	2.0	0.5	1.9	1.8
Arm predicted mass (right)	0.6	3.2	11.8	-0.4	-3.4	-3.0	-2.4	-2.2	0.7	0.4	1.3	-0.0	0.1	1.9	0.2
Pulse rate, automated reading	0.0	0.1	0.3	-0.5	-0.0	0.1	-0.2	0.1	0.6	-0.6	0.3	0.5	-0.2	0.3	-0.1
Alcohol intake frequency.	0.3	0.8	3.4	0.3	-1.1	-1.8	-1.5	-0.5	-0.3	0.8	-0.4	-0.3	-0.8	0.5	-0.7
Comparative height size at age 10	0.2	1.2	6.1	0.2	-0.2	-1.3	0.4	0.1	-0.7	0.9	-0.3	-1.9	-0.9	0.6	-2.5
Number of full sisters	0.1	0.1	0.3	-0.2	0.3	0.5	0.4	0.5	0.6	0.1	0.2	0.4	0.1	-0.4	0.5
Suffer from ‘nerves’	0.2	0.3	1.2	-0.2	0.8	1.1	0.2	0.5	-0.3	0.6	0.1	0.3	0.5	-0.4	-0.0
Overall health rating	0.4	0.9	3.5	-0.3	1.3	1.7	0.9	1.9	0.5	-0.5	0.8	0.1	0.4	-0.2	0.4
Chest pain or discomfort	0.9	1.3	3.5	-0.8	1.2	1.9	0.6	1.1	1.0	0.1	1.2	1.4	1.4	-0.8	1.5
Had major operations	0.4	0.5	1.5	1.2	0.1	-1.0	0.1	0.1	-0.6	0.9	-0.7	-0.1	-0.4	0.4	-1.2
Age at last live birth	0.6	0.8	1.8	1.0	1.0	0.8	1.2	0.7	-0.7	-0.8	-1.0	0.4	1.3	1.0	0.8
Family relationship satisfaction	0.3	0.3	1.3	0.2	-0.1	-0.5	-0.1	-0.5	-0.7	1.2	-0.9	-0.2	-0.7	0.4	-0.5
Leg pain on walking	1.0	1.3	1.7	-1.0	-1.3	-0.6	-1.3	-1.3	1.3	-1.2	1.2	1.3	1.2	-0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.8	0.7	0.1	-0.3	-0.0	-0.2	2.0	-0.2	2.4	1.3	1.1	-1.5	0.3
Commuting to job workplace: Car/motor vehicle	1.7	2.0	7.6	2.8	-0.6	-0.8	-0.5	-0.6	-1.9	-2.6	-1.7	-0.7	-0.1	-0.3	-1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.5	1.6	0.3	-0.4	1.2	0.5	-1.1	0.6	-1.4	-1.9	-1.4	-0.1	-1.7
Medication: Aspirin	1.1	1.4	3.6	-0.0	1.2	0.5	0.8	-0.4	-1.8	-1.0	-1.5	-1.3	-1.6	-0.1	-1.9
Supplements: Vitamin C	0.6	0.8	2.5	0.2	0.5	0.1	0.2	1.3	0.5	-0.8	0.5	0.3	1.2	-1.6	1.5
Knee pain experienced in last month	0.4	0.6	4.3	0.8	-0.3	0.5	-0.7	-0.6	-0.2	-2.1	0.4	0.6	0.4	0.6	0.7
Hypertension (Self-reported)	1.0	2.8	4.9	1.8	-1.1	-2.0	-0.4	-1.9	-2.1	-1.5	-1.7	-2.2	-1.9	0.5	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	5.2	-1.7	2.1	2.3	0.8	1.9	-0.5	0.5	-0.2	1.3	0.5	0.6	0.4
Illnesses of father: Heart disease	2.0	2.8	7.1	1.8	-0.9	-1.7	-1.7	-1.1	-2.4	1.1	-2.7	-0.0	-1.2	2.2	-1.4
Illnesses of siblings: Diabetes	0.4	0.5	2.1	0.0	-0.7	-0.2	-1.4	-0.5	0.2	1.4	0.5	0.6	0.0	1.0	-0.2
Smoking status: Previous	0.6	0.9	7.4	-2.7	0.2	0.1	0.6	-0.4	-0.8	0.2	-0.1	-0.1	-1.2	0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.0	-0.6	1.1	0.5	-0.4	0.6	0.9	0.2	0.9	-0.8	-1.4	-1.2	-1.0
Whole body fat-free mass	0.6	3.7	11.0	-0.6	-3.3	-2.9	-2.7	-2.3	0.6	1.1	1.5	0.6	0.1	2.7	0.5
Leg fat-free mass (right)	0.7	3.8	8.7	-1.0	-2.9	-1.8	-2.7	-1.9	1.3	2.2	2.0	1.6	0.6	2.5	1.7
Arm fat percentage (left)	1.4	5.5	12.5	-2.6	-2.7	-0.7	-2.1	-2.3	1.9	3.5	2.4	2.9	1.0	1.7	2.7
Average weekly red wine intake	0.6	0.9	4.0	-0.8	0.3	0.2	-0.3	0.1	-2.0	-1.2	-1.8	-0.2	0.3	1.1	0.4
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.9	1.3	1.7	1.0	1.3	1.4	-0.3	0.6	-1.2	-1.1	-1.7	-1.2	-1.4
Mood swings	0.5	1.0	3.3	0.4	1.0	1.8	1.7	1.3	0.7	-0.8	1.0	0.4	0.2	-0.6	-0.1
Loneliness, isolation	0.3	0.4	1.4	0.7	0.2	0.1	0.3	0.8	0.7	-0.3	0.8	-0.6	-0.0	-1.0	-1.2
Long-standing illness, disability or infirmity	0.5	0.8	2.4	-1.1	-0.7	-0.3	-1.6	-0.9	0.6	0.0	0.9	1.3	1.0	0.8	0.6
Ever had bowel cancer screening	0.5	0.6	3.7	-1.9	-0.8	-0.3	-0.7	-0.5	0.6	-0.0	0.6	0.7	0.4	0.3	0.7
Diabetes diagnosed by doctor	0.5	0.8	1.6	1.3	-0.5	-0.4	-1.1	-0.9	1.1	0.0	0.7	1.1	0.7	0.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.0	-0.6	2.0	1.8	1.6	1.6	0.4	-0.3	0.5	0.0	0.3	-1.5	0.1
Friendships satisfaction	0.7	0.8	2.2	0.4	-0.7	-1.4	-1.4	-0.9	-1.2	0.1	-1.5	-0.5	-0.6	-0.1	-0.6
Qualifications: nursing, teaching	1.4	2.1	6.2	1.2	2.3	1.1	1.5	2.5	0.7	0.5	0.6	-1.6	-0.4	-2.3	-0.4
Commuting to job workplace: Walk	0.7	0.8	2.7	-1.7	1.5	1.1	0.6	0.7	-0.1	1.0	-0.2	-1.1	-0.3	0.1	-0.0
Eye problems/disorders: Cataract	0.9	1.1	5.5	-0.0	-1.2	-0.3	-1.2	-0.8	-1.0	0.1	-1.2	1.0	-0.2	2.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.2	0.2	0.7	1.2	1.0	0.6	0.2	-1.6	0.2	0.8	0.6	-1.8	1.2
Medication for cholesterol	0.3	0.4	2.8	-0.7	0.6	0.3	0.4	0.5	0.7	0.1	0.3	-0.3	-0.0	-1.7	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	4.7	1.4	0.7	-0.4	-0.4	0.3	-2.2	0.4	-2.2	-1.0	-1.5	0.4	-1.3
Back pain experienced in last month	0.8	1.1	3.8	-1.9	0.0	0.9	0.3	0.6	0.9	-0.0	1.6	1.6	0.8	0.6	1.1
Mineral and other dietary supplements	0.5	0.7	2.4	1.5	0.7	1.0	0.9	0.9	-0.3	0.8	-0.3	0.5	0.2	1.5	0.3
Breast cancer (self-reported)	0.3	0.3	1.9	-0.6	-0.0	-0.2	-0.0	-0.4	-0.2	1.4	-0.2	-0.1	-0.6	0.8	-0.7
Asthma (self-reported)	0.7	1.4	2.9	-0.6	-1.7	-1.5	-1.1	-0.9	1.7	-0.3	1.7	1.1	0.6	0.5	1.3
Osteoporosis (self-reported)	0.4	0.5	2.2	-0.7	0.1	0.2	-0.4	-0.1	0.2	-1.5	0.6	0.0	0.9	-1.2	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.4	-0.2	-0.1	-0.9	-0.4	-0.8	-0.6	-0.5	-0.0	-0.6	0.7	-0.3
Medication: Aspirin	1.0	1.3	4.0	0.1	1.0	0.3	0.5	-0.5	-1.7	-0.5	-1.5	-1.2	-2.0	0.4	-1.8
Medication: Gliclazide	1.6	1.8	7.5	-0.3	-1.1	-1.2	-2.7	-1.7	0.4	-1.2	-0.2	1.6	0.7	0.8	1.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.7	0.3	0.6	0.9	0.5	0.5	-0.0	0.8	-0.4	0.8	-1.1	0.1
Smoking status: Current	0.3	0.4	1.3	-0.1	0.2	0.2	0.8	0.1	1.0	0.2	1.1	0.9	1.0	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	6.3	2.3	2.5	2.2	0.7	2.2	-1.3	-2.3	-1.1	-0.9	-0.8	0.0	-0.9
Whole body water mass	0.6	3.4	10.4	-0.5	-3.2	-2.9	-2.7	-2.2	0.5	1.1	1.4	0.4	-0.0	2.6	0.3
Leg predicted mass (right)	0.7	3.6	8.0	-1.0	-2.8	-1.7	-2.6	-1.8	1.2	2.3	1.9	1.5	0.5	2.4	1.6
Arm fat mass (left)	1.3	5.4	10.5	-2.5	-3.2	-1.5	-2.5	-2.6	1.8	3.0	2.4	2.3	0.7	2.0	2.1
Number of self-reported non-cancer illnesses	0.4	0.6	2.2	-1.3	0.7	0.8	1.5	1.0	-0.1	0.2	0.4	-0.5	-0.8	-0.7	-0.4
Average weekly champagne plus white wine intake	0.7	0.9	4.7	-2.2	0.5	1.1	0.0	0.3	0.9	-1.0	0.7	0.2	0.5	0.3	1.4
Miserableness	0.9	1.5	4.7	-0.2	1.9	2.0	2.1	2.2	0.4	-0.3	0.3	-0.4	-0.2	-0.5	-0.2
Guilty feelings	0.7	1.0	2.5	-0.0	1.5	1.0	0.8	1.6	-0.9	-0.6	-1.4	-0.8	-0.7	-0.9	-1.0
Wears glasses or contact lenses	0.6	0.7	2.0	-0.4	-0.7	-1.1	-0.2	-0.7	0.4	0.2	0.1	-0.7	-1.0	1.4	-1.4
Ever taken oral contraceptive pill	1.9	2.1	8.1	-1.1	0.6	1.2	0.2	0.2	2.3	-0.2	2.8	2.2	1.5	-0.8	1.0
Hearing aid user	0.5	0.5	1.4	0.6	0.8	0.6	0.7	0.6	0.9	1.2	1.0	0.7	0.1	-0.3	-0.3
Mother’s age at death	1.2	1.4	4.8	0.5	0.5	0.1	2.2	1.4	-0.1	1.3	-0.2	-1.3	-1.4	-0.9	-2.0
Financial situation satisfaction	0.7	0.9	2.6	0.2	0.8	-0.2	-0.4	0.1	-1.3	0.7	-1.6	-1.4	-1.0	-0.7	-1.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.2	0.7	-0.3	-1.1	-0.6	-0.6	0.5	-0.3	0.5	0.0	-0.0	-0.3	-0.5
Commuting to job workplace: Public transport	1.1	1.3	2.5	-1.3	-1.6	-1.4	-1.2	-1.4	0.9	1.1	1.2	0.7	0.5	1.1	0.8
Eye problems/disorders: Glaucoma	1.2	1.5	4.1	-0.7	-0.4	-0.6	-0.8	-0.5	-1.8	2.0	-2.0	-0.6	-1.2	1.0	-1.3
Medication: Blood pressure	1.2	2.2	5.2	1.4	-2.0	-2.1	-1.4	-2.0	-1.1	-1.0	-0.8	-0.9	-1.0	2.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.4	0.4	-1.5	-1.4	-0.8	-1.5	0.2	-1.3	0.6	0.9	-0.2	0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	-1.0	-0.9	-0.9	-0.6	-1.0	1.3	-0.0	1.4	0.1	0.2	-0.4	0.7
High cholesterol (Self-reported)	0.1	0.3	0.8	0.5	-0.0	0.6	-0.4	-0.2	0.0	-0.6	0.1	0.7	0.5	0.9	0.4
Medication: Bendroflumethiazide	1.2	1.9	6.1	2.5	-0.1	-0.6	1.3	0.3	-1.3	-0.2	-1.1	-2.0	-2.3	0.4	-1.4
Medication: Paracetamol	0.7	1.1	2.9	-1.4	-1.0	-0.6	-0.5	-0.9	1.7	-0.3	1.7	1.0	0.0	0.1	1.2
Medication: Lisinopril	1.4	1.8	9.2	3.0	-1.4	-1.6	-1.2	-1.0	-0.0	-2.0	-0.0	-1.0	-0.6	0.4	0.2
Medication: Atorvastatin	0.5	0.6	1.8	-0.5	-0.1	0.6	-0.7	-0.5	-1.2	-0.7	-1.0	1.3	0.3	1.1	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.8	-0.3	0.4	0.1	0.7	0.2	-1.3	-0.6	-0.9	-0.8	-0.9	0.5	-0.2
Alcohol drinker status: Never	0.9	1.1	8.2	0.4	-0.3	-0.4	-0.1	-0.1	-0.9	2.9	-0.5	0.6	-0.1	1.8	0.2
Ever smoked	0.2	0.4	2.1	-1.4	0.5	0.1	0.6	-0.2	-0.5	1.0	-0.5	0.2	-0.4	-0.2	-0.7
Basal metabolic rate	0.7	3.7	10.9	-1.0	-3.3	-2.6	-2.7	-2.4	0.8	1.6	1.7	0.8	0.1	2.5	0.7
Leg fat percentage (left)	0.9	3.3	8.5	-1.4	-2.9	-1.7	-1.7	-2.7	1.9	2.2	2.0	1.4	-0.1	0.7	0.9
Arm fat-free mass (left)	0.8	3.9	13.7	-0.2	-3.7	-3.4	-2.9	-2.7	0.4	0.5	1.3	0.0	-0.1	2.1	-0.1
Number of operations (self-reported)	0.8	1.2	3.6	0.9	-1.0	-0.3	-0.3	-0.6	1.2	0.4	1.5	1.7	1.9	1.2	0.7
Average weekly beer plus cider intake	1.1	1.6	4.5	1.0	-1.2	-0.4	-0.5	-1.0	1.7	-2.1	1.7	0.9	1.7	-1.0	1.2
Irritability	0.4	0.6	2.0	0.4	-0.7	-0.2	-1.1	-0.5	0.0	1.4	-0.0	1.1	0.4	1.3	0.5
Risk taking	0.9	1.4	2.6	-1.0	-0.7	-0.6	-1.1	-1.0	1.5	-1.4	1.5	1.6	1.3	0.5	0.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.9	-0.3	-0.5	-0.3	-0.8	-1.1	-1.1	-0.5	-1.0	0.4	-0.4	1.7	-1.0
Fractured/broken bones in last 5 years	1.4	1.8	5.7	-0.0	-0.2	0.7	-0.2	-0.1	2.4	-0.9	2.0	1.4	1.8	-1.4	1.7
Age started oral contraceptive pill	0.6	0.7	1.7	0.6	-1.3	-1.3	-1.1	-1.1	0.7	-0.7	0.8	0.4	0.9	0.5	0.2
Diastolic blood pressure, automated reading	0.6	1.7	5.5	0.3	-1.7	-1.7	-1.2	-2.3	0.6	-1.2	0.3	1.0	1.0	1.6	1.0
Ever depressed for a whole week	0.3	0.4	1.6	-0.4	-0.3	-0.2	-0.8	0.1	-0.6	1.2	0.3	0.8	-0.3	1.0	0.0
Unable to work because of sickness or disability	0.7	0.9	3.3	0.6	0.8	0.6	0.1	0.9	0.1	1.0	0.5	-0.8	-1.8	-0.7	-1.8
Commuting to job workplace: Cycle	1.9	2.3	8.8	-1.3	2.8	3.0	2.1	1.9	-0.2	0.0	-0.8	0.3	-0.0	0.2	0.9
Myopia	0.8	1.1	4.1	-0.6	1.7	2.0	0.4	1.2	-0.4	0.9	-0.3	0.8	1.4	-0.4	0.8
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.3	-1.3	0.6	1.1	-0.1	1.4	1.7	1.6	1.1	2.0	2.1	0.0	1.7
Cholesterol lowering medication	1.0	1.5	2.8	1.0	-1.7	-1.1	-1.5	-1.6	0.6	0.2	0.6	1.5	1.6	1.5	0.7
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	4.4	-2.0	0.5	0.6	0.6	0.4	-0.1	-2.1	0.0	0.7	0.8	0.9	0.1
Pain experienced in last month	0.8	1.4	7.1	0.2	-1.0	-0.9	-1.1	-0.9	-1.2	2.7	-1.4	-0.7	-0.6	0.9	-0.9
Supplements: Calcium	1.6	1.7	7.0	-2.2	1.4	1.3	0.9	1.8	-0.3	-0.6	-0.2	-0.6	-0.4	-2.6	-0.5
Basal cell carcinoma (self-reported)	1.2	1.4	4.3	-0.4	-1.3	-0.4	0.0	-0.9	0.5	-2.1	0.5	1.2	1.8	1.8	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.1	-0.5	0.2	0.2	0.6	0.1	-1.0	-0.5	-0.7	-0.5	-0.9	0.6	0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.4	0.7	-0.5	-0.3	-0.9	-0.7	0.7	-1.6	1.3	0.2	-0.4	0.4	-0.8
Heart disease (siblings)	1.7	2.1	5.7	-1.6	1.4	0.6	0.8	0.9	-2.1	-1.4	-2.4	-1.5	-1.6	-0.1	-1.7
Alcohol drinker status: Previous	1.1	1.2	4.1	-0.9	-0.8	-1.6	0.5	-0.4	-0.1	-0.4	0.1	-1.5	-2.0	-0.1	-2.0
Pack years of smoking	0.9	1.3	2.9	-0.6	-1.2	-0.4	-1.1	-0.9	1.7	-0.3	1.6	1.6	1.0	-0.1	1.5
Impedance of whole body	0.9	4.7	14.8	-0.2	3.9	3.1	3.4	2.7	0.6	-0.4	-0.6	-1.2	0.3	-3.2	-0.9
Leg fat mass (left)	1.4	5.3	13.2	-2.1	-3.6	-2.1	-2.4	-2.9	2.2	2.5	2.6	1.9	0.3	1.8	1.5
Arm predicted mass (left)	0.9	4.5	15.8	-0.2	-4.0	-3.7	-2.9	-3.0	0.6	0.5	1.3	-0.0	-0.3	2.1	-0.2