Hub : Genes

CDK19

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.2390 0.0680 1.2e-06 0.193 NA 0.132 NA 0.200 5.5e-09 NA 1.8e-06 NA 2.9e-09
2 METSIM Adipose 0.0547 0.0198 4.0e-05 0.023 0.032 0.025 0.031 0.021 2.0e-04 1.3e-05 9.8e-05 1.4e-05 3.0e-04
3 ROSMAP Brain Pre-frontal Cortex 0.1227 0.0273 1.7e-16 0.154 0.138 0.145 0.151 0.155 2.7e-19 2.4e-17 3.8e-18 6.3e-19 2.2e-19
4 TCGA Colon Adenocarcinoma 0.0610 0.0300 1.3e-03 0.056 0.042 0.019 NA 0.039 3.6e-04 1.9e-03 2.6e-02 NA 2.6e-03
5 TCGA Thyroid Carcinoma 0.0280 0.0160 5.0e-03 0.006 0.012 -0.002 NA 0.002 7.4e-02 2.3e-02 6.4e-01 NA 2.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.8 0.1 0.4 0.3 -0.9 -0.2
Bipolar Disorder or Schizophrenia 0.2 0.6 1.0 1.0 0.1 0.7 -1.0 -0.6
Depressed Affect (Nagel 2018) 0.1 0.2 0.8 0.4 -0.3 -0.1 0.2 -0.9
Depression (Nagel 2018) 0.4 0.6 0.9 0.8 -1.0 0.6 -0.6 -0.9
Intelligence (Savage-Jansen 2018) 0.6 2.0 3.7 -1.1 1.4 -0.9 1.5 1.9
Neuroticism (Nagel 2018) 0.1 0.3 1.1 0.7 -0.3 0.3 -0.1 -1.0
Schizophrenia (2018) 0.2 0.5 1.4 1.2 -0.2 0.7 -0.5 -0.6
Schizophrenia vs Biploar Disorder 0.6 0.8 1.9 -0.5 0.5 -1.2 1.4 0.4
Worry (Nagel 2018) 0.9 1.9 2.8 1.6 -1.1 1.5 -0.9 -1.7
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.3 -0.4 -0.4 0.7 0.2
Alzheimer’s Disease (in father) 0.5 0.5 1.0 0.6 -0.0 0.7 -1.0 -0.9
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 -0.6 0.3 -0.8 0.8 0.2
Crohns Disease (2017) 1.1 2.5 4.4 -1.5 2.1 -1.3 1.2 1.7
Irritable Bowel Disease (IBD) 2.5 6.0 10.2 -2.3 3.2 -1.9 1.9 2.7
Ulcerative Colitis (UC) 3.1 5.9 9.2 -2.2 3.0 -2.0 2.0 2.7
Major Depression (MDD) 0.2 0.2 0.6 -0.6 0.1 -0.2 0.8 -0.4
Reaction Time 0.1 0.2 0.5 -0.1 0.2 -0.2 0.5 0.7
Verbal and Numeric Reasoning (VNR) 0.4 1.1 2.4 -0.5 1.3 -0.6 0.9 1.5
Breast Cancer 2.3 5.5 9.6 2.4 -1.0 2.6 -3.1 -1.9
Ovarian Cancer 0.7 0.9 2.2 0.7 -1.5 0.4 -0.6 -1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.9 1.3 2.4 1.6 -1.0 1.3 -0.8 -0.8
Bipolar Disorder (2011) 0.3 0.3 0.6 0.2 -0.2 0.7 -0.8 -0.6
Body Mass Index (BMI) (2010) 1.1 1.6 3.6 1.2 -1.9 1.2 -1.0 -0.5
Coronary Artery Disease (CAD) 1.5 1.8 3.5 -1.7 0.5 -1.2 1.9 1.0
Crohns Disease (2012) 1.3 2.0 3.0 -1.4 1.7 -1.3 1.2 1.4
Mean Putamen Volume 2.7 3.1 4.8 -2.2 1.3 -1.9 1.9 1.3
Fasting Glucose 0.1 0.1 0.3 -0.1 -0.1 -0.6 0.1 0.1
HbA1C 1.3 1.5 3.7 -1.1 0.4 -1.4 1.9 0.7
HDL Cholesterol 2.1 3.4 5.5 -1.5 2.4 -1.8 1.1 2.2
LDL Cholesterol 0.2 0.2 0.4 0.6 -0.4 0.2 -0.6 -0.5
Lupus 0.9 1.4 2.1 -1.4 1.2 -1.3 1.2 0.6
Neuroticism (2016) 0.1 0.1 0.4 -0.2 -0.2 0.1 0.1 -0.6
Primary Biliary Cirrhosis 0.9 1.3 3.1 1.1 -1.0 1.8 -1.0 -0.7
Rheumatoid Arthritis 0.2 0.3 0.6 0.3 -0.7 0.1 -0.5 -0.7
Schizophrenia (2014) 0.1 0.1 0.3 0.5 0.5 0.1 0.1 0.2
Triglycerides 0.5 0.8 1.2 0.8 -1.0 1.1 -0.5 -0.8
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.4 -0.6 -0.0 0.0 0.2 -0.0
Ulcerative Colitis 3.2 4.6 7.7 -2.0 2.8 -1.9 1.4 2.4
Blood Eosinophil Count 0.8 5.8 7.4 2.5 -2.5 2.7 -1.6 -2.5
Blood Platelet Count 0.0 0.4 1.1 0.8 -1.0 0.0 -0.2 -0.1
Blood Red Count 0.5 5.2 16.8 1.7 -4.1 1.6 -1.5 -1.3
Blood White Count 0.1 0.7 1.8 0.3 -1.3 -0.2 -0.1 -1.2
Heel T-Score 0.1 0.7 1.3 -1.1 -1.1 -0.8 0.4 -0.4
BMI 0.2 1.0 3.5 0.2 -1.9 0.1 0.3 -1.2
Height 0.6 11.2 16.6 -3.3 4.1 -3.4 1.9 3.6
Waist Hip Ratio (WHR) 0.3 1.5 2.7 0.7 -0.8 1.6 -1.3 -1.5
Systolic Blood Pressure 0.8 3.9 7.0 -1.5 2.6 -1.9 1.5 2.0
Smoking Status 0.3 0.6 1.6 -1.0 0.4 -0.6 1.3 -0.1
Allergy or Eczema 1.0 2.7 5.0 2.0 -0.7 2.2 -1.6 -1.3
Cardiovascular Disease 0.8 2.8 6.2 1.1 -2.5 1.2 -1.1 -2.0
Hypothyroidism (self reported) 0.2 0.4 0.8 0.3 -0.9 0.8 -0.6 -0.6
Respiratory disease 0.2 0.5 0.7 -0.9 0.8 -0.5 0.8 0.5
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.7 0.9 -1.5 1.0 -0.9 -1.9
Lung FEV1/FVC ratio 0.1 0.7 2.3 0.5 -1.5 0.6 -0.2 -0.7
Lung FVC 0.3 1.4 2.5 1.3 0.2 1.6 -1.1 -1.2
Neuroticism 0.8 1.9 2.9 1.7 -1.0 1.4 -1.1 -1.6
Chronotype (morning person) 0.9 2.2 2.8 -1.6 1.7 -1.5 0.9 1.6
Hair Pigment 0.0 0.7 1.6 -1.1 0.7 -1.2 0.4 0.6
Tanning 0.6 7.0 8.6 -2.7 2.2 -2.9 2.5 2.8
Hand grip strength (left) 0.0 0.0 0.1 -0.0 -0.3 0.1 -0.1 -0.1
Number of treatments/medications taken 1.9 3.4 6.4 1.2 -2.5 1.4 -1.7 -2.1
Average weekly spirits intake 0.5 0.7 1.6 0.8 -0.6 0.8 -0.3 -1.3
Sensitivity / hurt feelings 0.7 1.1 1.5 1.2 -0.9 1.2 -1.0 -1.0
Frequency of depressed mood in last 2 weeks 1.2 1.6 2.2 1.3 -1.5 1.3 -1.0 -1.2
Hearing difficulty/problems: Yes 0.4 0.5 1.3 -0.9 -0.3 -0.8 1.1 0.1
Relative age of first facial hair 0.3 0.6 1.2 -1.1 0.3 -1.1 0.7 0.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 2.2 0.7 -1.5 0.9 -0.7 -1.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.1 -0.8 0.4 -1.0 0.9 0.9
Ever had hysterectomy (womb removed) 2.3 2.6 4.3 1.7 -1.9 2.1 -1.0 -0.9
Systolic blood pressure, automated reading 1.4 4.2 6.0 -1.9 2.2 -2.5 1.8 1.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 -0.3 0.5 -0.7 0.9 0.1
Angina 0.3 0.4 0.7 -0.8 0.1 -0.9 0.7 -0.3
Medication for hormone replacement therapy 0.1 0.1 0.4 -0.6 0.3 -0.3 0.3 0.1
Vitamin and mineral supplements 1.3 1.8 2.9 1.3 -0.7 1.2 -1.6 -1.7
Supplements: Zinc 4.7 5.1 9.9 -2.4 0.9 -2.3 3.2 1.9
Medication: Co-codamol 2.7 3.1 5.4 1.6 -1.9 1.6 -1.1 -2.3
Medication: Metformin 0.1 0.2 0.3 -0.5 -0.1 -0.3 0.6 -0.4
Diabetes (father) 1.5 1.8 4.8 -1.0 0.9 -1.0 1.1 2.2
Diabetes (mother) 0.0 0.0 0.1 -0.1 0.1 -0.2 -0.3 -0.2
Severe depression (siblings) 4.9 5.5 6.7 -2.3 2.6 -2.5 2.3 2.0
Pack years adult smoking proportion 1.1 1.7 2.3 1.4 -1.5 1.2 -1.2 -1.3
Impedance of leg (right) 0.1 0.4 0.7 0.4 -0.8 0.7 -0.5 -0.7
Leg fat-free mass (left) 0.5 2.7 3.7 -1.7 1.9 -1.8 1.2 1.4
Trunk fat percentage 0.3 1.1 4.0 0.0 -2.0 -0.0 0.0 -1.1
Hand grip strength (right) 0.4 1.2 1.9 0.8 -1.0 1.0 -1.1 -1.4
Townsend deprivation index at recruitment 4.9 6.9 8.2 2.6 -2.9 2.5 -2.4 -2.8
Current tobacco smoking 1.1 1.8 3.2 1.2 -1.8 1.1 -0.2 -1.8
Average weekly fortified wine intake 0.2 0.3 0.6 0.5 -0.3 0.4 -0.4 -0.8
Maternal smoking around birth 0.6 0.8 1.9 -0.9 1.4 -1.0 0.4 0.6
Fed-up feelings 1.0 1.8 3.4 1.3 -1.2 1.2 -0.9 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 2.2 1.4 -1.4 1.0 -1.0 -1.5
Relative age voice broke 0.9 1.4 2.3 -1.5 0.6 -1.3 1.3 1.1
Taking other prescription medications 0.4 0.7 2.0 0.1 -1.4 0.7 -0.3 -0.9
Age when periods started (menarche) 2.2 5.2 7.4 2.1 -2.7 2.3 -1.6 -2.5
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 3.0 0.3 -1.7 0.6 -0.2 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 -0.1 0.3 0.2 0.3 -0.1
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 0.9 -0.9 1.0 -0.8 0.6 0.9
Qualifications: CSEs or equivalent 2.8 3.8 6.6 1.5 -2.3 2.0 -0.9 -2.6
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.3 -0.5 0.2 -0.0 -0.2
High blood pressure 1.0 2.7 5.1 1.3 -2.2 1.2 -1.3 -1.9
Hayfever, allergic rhinitis or eczema 3.1 6.7 10.5 3.0 -1.6 3.2 -2.6 -2.3
Multivitamins +/- minerals 0.5 0.7 1.5 -0.5 0.0 -0.3 1.2 1.2
Stomach or abdominal pain in last month 0.5 0.6 2.0 -0.5 1.4 -0.6 0.3 0.6
Supplements: Glucosamine 0.6 0.7 1.5 -1.1 0.3 -1.2 0.9 0.3
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.1 0.7 -0.5 1.1 -0.9 -1.5
Medication: Atenolol 0.4 0.5 1.0 0.5 -0.7 1.0 -0.6 -0.7
Medication: Levothyroxine sodium 0.1 0.2 0.4 -0.6 -0.6 -0.4 0.5 -0.2
Sitting height 0.3 2.3 4.5 -1.6 2.1 -1.6 0.5 1.2
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.2 0.1 0.1 0.1 0.3
High blood pressure (mother) 0.6 0.9 1.2 -1.0 0.9 -1.1 0.8 0.7
Body mass index (BMI) 0.2 0.9 2.7 0.4 -1.6 0.2 -0.1 -1.2
Impedance of leg (left) 0.2 1.1 1.8 0.8 -1.3 1.1 -0.8 -1.2
Leg predicted mass (left) 0.6 2.9 4.0 -1.8 2.0 -1.9 1.3 1.5
Trunk fat mass 0.1 0.5 1.8 -0.3 -1.4 -0.4 0.2 -0.8
Waist circumference 0.2 0.9 2.3 0.5 -1.5 0.3 -0.5 -1.2
Number of incorrect matches in round 0.5 0.9 2.6 0.3 -1.6 0.6 -0.5 -1.0
Past tobacco smoking 0.6 1.0 2.0 1.4 -0.7 1.0 -1.3 -0.0
Alcohol usually taken with meals 0.9 1.5 2.7 -1.0 1.6 -1.1 0.7 1.3
Nervous feelings 2.1 3.9 5.8 2.3 -1.2 2.4 -1.8 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.4 0.7 -0.7 0.3 0.7
Hearing difficulty/problems with background noise 0.1 0.1 0.4 -0.2 -0.4 -0.1 0.6 -0.3
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 -0.5 -0.3 -0.2 0.3 0.0
Had menopause 0.2 0.2 0.9 0.1 -0.9 0.3 0.1 -0.2
Had other major operations 0.5 0.7 1.4 0.8 -1.2 1.0 0.0 -0.5
Forced vital capacity (FVC) 0.4 1.6 5.7 -1.1 2.4 -0.6 0.8 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 0.0 -0.0 0.5 -0.1 -0.4
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 -0.1 0.1 0.2 0.1 -0.1
Qualifications: None of the above 1.4 2.9 4.4 1.3 -2.1 1.5 -1.6 -1.9
Financial difficulties in last 2 years 1.1 1.5 2.2 1.5 -1.2 1.3 -0.9 -1.1
Mouth/teeth dental problems 1.9 3.0 4.2 1.7 -0.7 1.9 -1.9 -2.0
Heart attack 0.1 0.2 0.4 -0.6 -0.2 0.0 0.6 0.2
Allergy 0.7 1.6 3.3 -1.5 0.5 -1.8 1.2 0.9
Pain all over the body in last month 0.0 0.0 0.1 0.3 0.0 -0.1 0.1 -0.1
Diabetes (self-reported) 0.6 1.0 1.9 0.7 -1.3 0.9 -0.3 -1.4
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 3.9 1.5 0.2 2.0 -1.4 -1.0
Medication: Ramipril 0.4 0.6 0.9 -0.9 0.6 -0.6 0.6 0.9
Medication: Simvastatin 3.5 5.2 8.3 2.2 -2.9 1.9 -1.8 -2.3
Fluid intelligence score 0.3 0.5 1.4 -0.4 0.3 -0.6 0.8 1.2
Illnesses of siblings 1.1 1.6 2.4 -1.1 1.3 -1.0 1.2 1.6
Neuroticism score 1.0 2.2 3.6 1.6 -1.1 1.4 -1.1 -1.9
Weight 0.1 0.5 1.2 -0.9 0.2 -1.1 0.6 0.2
Impedance of arm (right) 0.1 0.5 1.3 -0.8 0.1 -0.5 0.7 1.1
Arm fat percentage (right) 0.3 1.3 4.4 0.6 -2.1 0.4 -0.2 -1.2
Trunk fat-free mass 0.5 2.6 5.7 -1.4 2.4 -1.7 0.8 1.3
Hip circumference 0.2 0.9 2.6 0.6 -1.6 0.1 -0.5 -1.2
Time employed in main current job 0.3 0.3 0.8 -0.6 -0.3 -0.5 0.9 -0.3
Alcohol intake versus 10 years previously 3.9 5.9 7.6 2.1 -2.8 2.4 -2.3 -2.6
Father’s age at death 3.9 5.2 8.5 -2.4 2.9 -2.0 1.6 2.2
Worrier / anxious feelings 0.7 1.3 1.6 1.2 -1.3 1.2 -0.6 -1.2
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 5.3 2.2 -1.6 2.1 -2.2 -2.3
Falls in the last year 0.8 1.1 1.8 -1.1 1.3 -1.0 0.9 0.9
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 0.8 -0.2 0.6 -0.3 -0.2
Number of live births 1.2 1.7 2.2 1.4 -1.4 1.4 -1.5 -1.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 5.0 -1.0 2.2 -0.4 0.8 0.7
Pulse rate 0.7 1.2 2.1 1.1 -0.9 0.8 -1.4 -1.2
Happiness 0.5 0.6 0.9 0.9 -0.8 1.0 -0.8 -0.5
Noisy workplace 0.6 0.7 1.1 -1.1 0.5 -1.0 0.9 0.7
Qualifications: A levels/AS levels or equivalent 2.3 5.2 9.4 -1.7 3.1 -1.6 1.9 2.8
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 2.5 -1.4 1.6 -1.2 1.1 1.4
Mouth/teeth dental problems: Dentures 0.9 1.6 3.3 -1.4 0.2 -1.8 1.4 0.8
Asthma 0.3 0.7 1.0 -0.8 0.9 -0.4 0.8 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 1.0 -1.0 0.9 -1.0 0.6 1.0
Medication: Cholesterol lowering 0.3 0.5 1.9 0.4 -1.4 0.1 -0.4 -0.7
Depression (self-reported) 0.9 1.0 2.0 1.1 -0.0 1.1 -1.4 -0.9
Medication: Lansoprazole 1.0 1.1 1.7 -1.1 0.6 -1.2 1.3 1.0
Prospective memory result 2.2 2.7 3.1 1.8 -1.6 1.6 -1.5 -1.6
Lung cancer (father) 1.3 1.5 2.8 1.0 -0.4 1.2 -1.7 -1.5
Illnesses of mother 0.1 0.2 0.6 -0.4 0.2 0.2 0.7 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.5 -0.1 1.2 0.2 0.5 -0.4
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 -0.4 0.4 -0.8 0.5 0.0
Impedance of arm (left) 0.0 0.2 0.6 -0.4 -0.2 -0.1 0.3 0.8
Arm fat mass (right) 0.1 0.5 1.6 -0.1 -1.3 -0.2 0.3 -0.8
Trunk predicted mass 0.4 2.4 5.5 -1.4 2.3 -1.6 0.8 1.3
Standing height 0.9 9.4 15.4 -3.2 3.9 -3.0 1.8 3.0
Length of working week for main job 0.2 0.2 0.5 -0.4 0.5 -0.4 0.7 0.1
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.3 0.3 -0.2 -0.4 -0.0
Breastfed as a baby 0.3 0.4 0.9 0.6 -1.0 0.5 -0.7 -0.2
Tense / ‘highly strung’ 0.2 0.3 0.9 -0.4 0.9 -0.3 0.5 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 1.8 -1.1 1.4 -1.1 0.6 1.0
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 -0.4 0.8 -0.5 0.2 0.6
Birth weight of first child 0.9 1.7 3.0 -1.2 1.7 -0.9 0.8 1.6
Peak expiratory flow (PEF) 2.1 4.8 7.1 -2.2 2.7 -1.7 1.9 2.4
Pulse wave reflection index 0.4 0.4 0.7 -0.7 0.3 -0.7 0.8 0.7
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.4 1.0 -0.8 0.9 -1.2 -0.9
Loud music exposure frequency 0.9 1.0 1.4 -1.1 0.8 -1.2 1.1 0.8
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 3.7 -1.6 1.7 -1.4 1.3 1.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.5 -0.3 -0.2 -0.2 0.4 0.7
Blood clot in the leg (DVT) 0.4 0.5 0.7 -0.8 -0.2 -0.7 0.9 0.7
Medication: Paracetamol 2.0 3.3 4.9 -1.9 1.4 -2.2 2.0 1.5
Headache pain in last month 0.0 0.0 0.1 -0.1 -0.2 -0.2 -0.2 -0.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.8 0.7 0.8 0.9 -0.1 0.0
Glaucoma (self-reported) 0.4 0.5 0.8 -0.6 0.8 -0.7 0.3 0.9
Gout (self-reported) 0.2 0.3 0.9 0.2 -0.5 0.2 -0.4 -0.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.9 0.0 -1.0 0.5 -0.1 -0.4
Medication: Amlodipine 2.2 3.1 4.3 1.8 -1.6 1.6 -2.1 -1.6
Medication: Ventolin 100micrograms inhaler 2.2 2.8 3.8 -1.7 1.9 -1.6 1.2 2.0
Birth weight 3.8 8.3 10.0 -2.9 3.1 -3.2 2.8 2.4
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 0.8 -0.9 0.7 -0.3 -0.6
High blood pressure (siblings) 0.1 0.1 0.3 -0.1 -0.5 -0.3 0.1 -0.4
Forced vital capacity (FVC), Best measure 0.1 0.5 2.1 -0.3 1.4 -0.0 0.5 -0.3
Body fat percentage 0.5 1.9 6.7 0.5 -2.6 0.4 -0.2 -1.5
Leg fat percentage (right) 1.0 3.5 8.5 1.4 -2.9 1.2 -0.8 -2.2
Arm fat-free mass (right) 0.2 1.0 2.1 -1.1 1.5 -1.1 0.6 0.4
Exposure to tobacco smoke outside home 2.0 2.6 3.8 -1.9 1.0 -1.8 2.0 1.2
Comparative body size at age 10 0.6 1.7 3.3 -1.0 0.8 -1.3 1.8 1.3
Number of full brothers 4.3 5.4 9.0 1.9 -3.0 2.2 -1.4 -2.8
Worry too long after embarrassment 0.0 0.0 0.0 0.1 -0.1 -0.0 0.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 0.8 -0.3 0.8 -1.0 -0.5
Wheeze or whistling in the chest in last year 0.4 0.7 1.0 -0.8 1.0 -0.8 0.5 0.9
Number of children fathered 0.3 0.4 1.2 0.5 -0.4 0.0 -1.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 3.5 -1.7 1.4 -1.7 1.6 1.9
Age at first live birth 2.8 5.0 6.4 -2.2 2.1 -2.2 2.1 2.5
Pulse wave peak to peak time 0.2 0.3 0.8 0.5 -0.4 0.9 -0.5 -0.1
Health satisfaction 1.0 1.3 2.5 0.8 -1.4 1.1 -0.4 -1.6
Shortness of breath walking on level ground 0.9 1.1 2.6 0.8 -1.6 0.7 -0.4 -1.2
Qualifications: College or University degree 5.5 17.3 25.4 -3.8 5.0 -3.8 3.2 4.7
Eye problems/disorders: None of the above 1.9 2.2 4.0 -1.4 1.5 -1.2 1.1 2.0
Mouth/teeth dental problems: Loose teeth 1.9 2.3 4.0 -1.5 1.5 -1.2 1.3 2.0
Emphysema/chronic bronchitis 0.1 0.1 0.4 -0.4 0.2 -0.6 -0.0 -0.0
Medication for pain relief, constipation, heartburn 0.1 0.1 0.3 0.4 0.1 0.6 -0.0 0.1
Neck or shoulder pain in last month 0.1 0.2 0.7 -0.2 -0.8 -0.0 0.3 -0.3
Medication: Blood pressure 0.2 0.4 1.2 -0.8 -0.4 -1.1 -0.0 -0.2
Angina (self-reported) 0.2 0.3 0.4 -0.5 -0.0 -0.6 0.5 -0.6
Migraine (self-reported) 0.1 0.2 0.4 0.3 -0.5 0.1 -0.4 -0.6
Medication: Ibuprofen 2.0 2.4 3.7 -1.9 1.2 -1.7 1.5 1.4
Medication: Allopurinol 0.2 0.2 0.7 0.0 -0.3 -0.1 -0.6 -0.8
Medication: Omeprazole 0.0 0.1 0.1 -0.1 -0.1 -0.3 -0.3 0.2
Medication: Seretide 50 evohaler 0.8 0.9 1.6 -1.3 1.1 -1.1 0.4 0.6
Mean time to correctly identify matches 0.1 0.3 0.7 -0.3 -0.2 -0.4 0.6 0.8
Heart disease (mother) 0.6 0.7 1.4 0.5 -0.7 0.4 -1.2 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.1 -0.9 1.0 -0.5 0.6 1.0
Whole body fat mass 0.1 0.6 2.0 -0.3 -1.4 -0.4 0.3 -0.7
Leg fat mass (right) 0.1 0.5 1.8 -0.2 -1.3 -0.3 0.4 -0.8
Arm predicted mass (right) 0.2 1.0 2.2 -1.0 1.5 -1.2 0.6 0.4
Pulse rate, automated reading 0.4 1.2 1.6 1.3 -1.3 0.6 -1.1 -1.1
Alcohol intake frequency. 1.9 4.4 6.6 2.2 -1.8 2.2 -2.6 -1.7
Comparative height size at age 10 0.4 2.1 5.2 -1.3 2.3 -1.2 0.5 1.3
Number of full sisters 1.7 2.0 2.8 1.5 -1.0 1.3 -1.7 -1.5
Suffer from ‘nerves’ 0.1 0.1 0.4 0.0 0.2 -0.1 0.6 -0.2
Overall health rating 2.5 5.4 10.6 1.8 -3.3 2.1 -1.1 -2.7
Chest pain or discomfort 0.3 0.4 0.6 -0.7 0.5 -0.4 0.8 0.6
Had major operations 3.0 3.5 5.2 -2.0 1.6 -1.9 1.4 2.3
Age at last live birth 1.3 1.9 4.0 -1.3 2.0 -1.1 0.8 1.4
Family relationship satisfaction 0.2 0.3 0.9 0.0 0.9 0.2 -0.5 0.4
Leg pain on walking 0.2 0.2 0.4 -0.6 0.2 -0.5 0.7 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 2.8 1.1 -1.7 1.4 -0.4 -1.5
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 -0.4 0.5 -0.3 0.9 0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.5 0.1 -1.2 0.2 0.1 -0.3
Medication: Aspirin 2.5 3.3 4.6 1.5 -1.9 1.7 -1.7 -2.1
Supplements: Vitamin C 1.2 1.4 2.2 -1.5 0.6 -1.2 1.2 1.2
Knee pain experienced in last month 0.2 0.3 0.5 -0.7 0.0 -0.6 0.2 0.7
Hypertension (Self-reported) 1.1 3.2 6.1 1.4 -2.5 1.3 -1.3 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.6 -0.7 0.4 -0.5 0.8 0.7
Illnesses of father: Heart disease 0.1 0.1 0.2 0.0 -0.5 0.2 -0.3 -0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.4 -0.4 0.4 -0.6 -0.4
Smoking status: Previous 0.6 1.0 2.1 -1.4 0.7 -0.9 1.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 5.1 -1.8 2.3 -1.6 1.9 1.7
Whole body fat-free mass 0.5 2.6 4.8 -1.6 2.2 -1.8 1.0 1.3
Leg fat-free mass (right) 0.4 2.4 3.5 -1.6 1.9 -1.7 1.1 1.3
Arm fat percentage (left) 0.4 1.5 4.7 0.7 -2.2 0.6 -0.3 -1.4
Average weekly red wine intake 2.6 3.8 8.4 -1.4 2.9 -1.6 1.3 2.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.5 -0.6 0.7 -0.4 0.6 0.6
Mood swings 0.0 0.1 0.3 -0.1 0.5 -0.2 0.2 -0.2
Loneliness, isolation 0.4 0.5 0.9 0.6 -0.9 0.5 -0.6 -0.9
Long-standing illness, disability or infirmity 0.8 1.2 2.3 0.7 -1.2 1.1 -0.6 -1.5
Ever had bowel cancer screening 1.2 1.4 2.1 1.4 -1.1 1.0 -1.4 -0.8
Diabetes diagnosed by doctor 0.9 1.5 2.8 0.8 -1.5 1.1 -0.6 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.2 1.8 -1.0 1.3 -1.4 -1.1
Friendships satisfaction 0.2 0.3 0.4 0.6 -0.1 0.5 -0.7 0.4
Qualifications: nursing, teaching 1.4 2.2 4.8 -0.9 2.2 -1.1 0.6 1.9
Commuting to job workplace: Walk 0.6 0.6 1.0 0.9 -0.3 1.0 -0.9 -0.5
Eye problems/disorders: Cataract 0.5 0.5 1.2 0.6 -0.9 0.4 -0.5 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 -0.2 -0.3 0.4 0.5 0.3
Medication for cholesterol 3.2 4.9 6.8 -2.1 2.6 -2.0 1.6 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 -0.6 0.1 -0.7 0.9 0.5
Back pain experienced in last month 3.2 4.6 8.2 1.7 -2.9 1.7 -1.6 -2.5
Mineral and other dietary supplements 1.4 1.9 3.2 1.4 -1.4 1.8 -1.1 -1.1
Breast cancer (self-reported) 0.0 0.0 0.0 0.1 0.1 0.1 0.2 -0.1
Asthma (self-reported) 0.2 0.5 0.7 -0.8 0.8 -0.2 0.7 0.8
Osteoporosis (self-reported) 0.7 0.8 1.8 1.1 -0.6 0.6 -1.3 -0.8
Osteoarthritis (self-reported) 0.0 0.0 0.1 0.0 0.0 -0.3 -0.2 0.1
Medication: Aspirin 3.5 4.5 6.0 1.9 -2.1 2.2 -2.0 -2.4
Medication: Gliclazide 0.1 0.1 0.4 -0.6 0.4 -0.2 0.2 -0.1
Illnesses of father: None of the above (group 1) 1.3 1.6 2.1 -1.3 1.4 -1.2 1.4 0.8
Smoking status: Current 0.6 0.9 1.9 0.8 -1.2 0.7 0.1 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 4.5 2.1 -0.8 1.9 -1.5 -1.5
Whole body water mass 0.4 2.3 4.2 -1.5 2.0 -1.7 1.0 1.2
Leg predicted mass (right) 0.5 2.5 3.7 -1.6 1.9 -1.8 1.2 1.3
Arm fat mass (left) 0.2 0.7 2.2 0.2 -1.5 0.2 0.0 -1.1
Number of self-reported non-cancer illnesses 0.9 1.5 3.8 0.6 -1.9 0.9 -0.7 -1.4
Average weekly champagne plus white wine intake 2.7 3.7 6.3 -1.7 2.5 -1.8 1.3 2.1
Miserableness 0.1 0.2 1.0 0.0 1.0 -0.3 -0.1 -0.2
Guilty feelings 2.0 3.0 3.9 1.8 -1.5 1.7 -2.0 -1.7
Wears glasses or contact lenses 0.3 0.4 0.9 0.6 -0.3 0.3 -0.6 -0.9
Ever taken oral contraceptive pill 0.5 0.5 0.9 -0.7 0.7 -0.9 1.0 -0.0
Hearing aid user 0.3 0.3 1.1 -0.1 -1.1 -0.2 0.7 -0.2
Mother’s age at death 0.1 0.1 0.3 0.3 0.4 -0.0 -0.3 0.5
Financial situation satisfaction 1.1 1.4 2.3 1.1 -1.5 1.0 -1.4 -0.6
Tinnitus: Yes, now most or all of the time 1.8 2.1 2.7 -1.6 1.4 -1.4 1.1 1.6
Commuting to job workplace: Public transport 0.2 0.2 0.6 -0.3 0.3 -0.1 0.4 0.8
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 0.2 0.3 0.1 -0.2 -0.0
Medication: Blood pressure 2.7 5.2 6.3 2.5 -2.4 2.5 -1.7 -2.3
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.6 -0.6 -0.0 -0.7 0.6 -0.8
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.6 -0.0 0.5 -0.8 -0.0 0.3
High cholesterol (Self-reported) 4.8 8.6 15.1 2.4 -3.9 2.4 -2.4 -3.2
Medication: Bendroflumethiazide 0.5 0.8 1.4 -1.0 0.3 -0.9 1.2 0.8
Medication: Paracetamol 3.2 4.9 7.6 -2.4 1.5 -2.8 2.5 1.7
Medication: Lisinopril 1.2 1.6 3.7 0.6 -1.9 0.6 -0.7 -1.7
Medication: Atorvastatin 0.3 0.4 0.8 0.0 -0.9 0.1 -0.6 -0.9
Illnesses of father: High blood pressure 0.2 0.2 0.8 0.3 -0.9 0.3 0.0 0.1
Alcohol drinker status: Never 0.0 0.1 0.1 -0.1 -0.1 -0.2 0.3 0.4
Ever smoked 0.3 0.6 1.1 -1.0 0.6 -0.7 1.0 -0.1
Basal metabolic rate 0.3 1.8 2.8 -1.4 1.7 -1.6 0.9 0.9
Leg fat percentage (left) 1.3 4.7 10.6 1.7 -3.2 1.4 -1.1 -2.6
Arm fat-free mass (left) 0.2 0.8 1.4 -1.0 1.1 -1.2 0.6 0.4
Number of operations (self-reported) 0.1 0.1 0.2 -0.3 -0.2 -0.2 0.5 0.5
Average weekly beer plus cider intake 6.6 9.5 17.4 2.7 -4.2 3.0 -2.2 -3.0
Irritability 0.0 0.1 0.2 0.4 0.0 0.2 -0.2 -0.4
Risk taking 5.5 8.0 10.0 -3.2 2.5 -2.8 2.9 2.7
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.3 0.5 0.5 0.4 -0.2 0.3
Fractured/broken bones in last 5 years 6.3 8.2 9.4 -2.9 2.8 -2.9 2.6 3.1
Age started oral contraceptive pill 0.4 0.5 0.9 -0.5 0.8 -1.0 0.4 0.8
Diastolic blood pressure, automated reading 0.7 2.0 4.0 -1.5 1.0 -2.0 1.6 0.7
Ever depressed for a whole week 0.1 0.1 0.4 -0.5 0.1 -0.0 0.6 -0.1
Unable to work because of sickness or disability 0.4 0.5 0.9 -0.9 0.8 -0.8 0.7 0.1
Commuting to job workplace: Cycle 0.3 0.4 0.6 -0.4 0.6 -0.6 0.8 0.8
Myopia 0.6 0.9 2.0 -0.6 1.4 -0.2 0.2 1.4
Vascular/heart problems diagnosed by doctor 0.9 2.5 5.4 -1.2 2.3 -1.1 1.1 1.8
Cholesterol lowering medication 4.9 7.1 10.2 2.4 -3.2 2.6 -2.3 -2.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.6 0.2 -0.6 0.1 -0.8 -0.3
Pain experienced in last month 0.2 0.3 0.7 0.8 -0.1 0.6 -0.7 -0.3
Supplements: Calcium 0.9 1.0 2.1 1.5 -0.8 1.1 -0.7 -0.8
Basal cell carcinoma (self-reported) 1.7 2.1 3.9 -1.2 1.5 -1.4 0.8 2.0
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 -0.2 -0.4 0.3 0.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 -0.7 -0.1 -0.8 0.7 0.7
Heart disease (siblings) 1.4 1.7 2.5 1.0 -1.2 1.0 -1.5 -1.6
Alcohol drinker status: Previous 1.2 1.3 2.8 1.2 -0.7 0.8 -1.7 -1.1
Pack years of smoking 0.8 1.1 1.7 1.1 -1.3 0.9 -1.0 -1.0
Impedance of whole body 0.0 0.2 0.7 0.1 -0.8 0.5 -0.1 -0.2
Leg fat mass (left) 0.2 0.7 2.4 0.0 -1.6 -0.1 0.2 -1.0
Arm predicted mass (left) 0.1 0.7 1.2 -0.9 1.1 -1.1 0.5 0.3