Hub : Genes

CHRNB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0270	0.00022	0.071	0.026	0.060	0.044	0.058	5.2e-09	0.00033	7.9e-08	4.0e-06	1.4e-07
2	METSIM	Adipose	0.0419	0.0171	0.00150	0.018	0.019	0.000	0.018	0.008	8.8e-04	0.00063	3.3e-01	7.8e-04	1.6e-02
3	NTR	Blood	0.0225	0.0086	0.00098	0.018	0.005	0.013	0.008	0.012	1.2e-06	0.00700	2.8e-05	1.1e-03	5.6e-05
4	TCGA	Lung Adenocarcinoma	0.0321	0.0171	0.00190	0.011	0.024	0.027	NA	0.018	1.6e-02	0.00069	3.5e-04	NA	2.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.1	0.8	0.5	0.1
Bipolar Disorder or Schizophrenia	0.6	1.5	4.0	-0.7	0.1	2.0	1.2
Depressed Affect (Nagel 2018)	0.7	1.5	6.0	-0.1	-0.3	-2.5	0.2
Depression (Nagel 2018)	0.6	0.9	2.3	-0.1	-0.8	-1.5	-0.7
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.8	-0.8	-2.2	-1.8	0.3
Neuroticism (Nagel 2018)	0.9	2.2	7.5	0.6	-0.3	-2.7	-0.9
Schizophrenia (2018)	0.9	1.8	4.6	-0.9	-0.6	2.1	1.2
Schizophrenia vs Biploar Disorder	0.7	0.9	2.1	-0.4	-1.5	-0.2	1.1
Worry (Nagel 2018)	0.3	0.7	2.2	0.1	0.8	-1.5	-0.4
Alzheimer’s Disease (in mother)	2.7	3.1	7.3	2.7	-0.3	-1.5	-1.6
Alzheimer’s Disease (in father)	3.3	3.6	6.4	2.5	-1.6	-1.4	-1.8
Alzheimer’s Disease (including proxy)	2.2	3.1	8.8	3.0	-1.0	-1.1	-1.2
Crohns Disease (2017)	0.3	0.7	2.2	-0.6	1.5	-0.0	-0.4
Irritable Bowel Disease (IBD)	0.5	1.3	2.2	0.7	0.8	-1.4	-1.5
Ulcerative Colitis (UC)	1.1	2.1	3.9	1.1	0.3	-2.0	-1.8
Major Depression (MDD)	3.3	4.0	9.6	1.9	-1.3	-3.1	-1.1
Reaction Time	0.2	0.3	0.9	0.3	-0.5	-0.4	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.5	0.2	-1.9	-1.7	-0.6
Breast Cancer	0.6	1.3	2.6	-0.7	-0.4	1.6	1.4
Ovarian Cancer	1.1	1.4	3.7	-1.0	1.9	0.7	0.6
Prostate Cancer	0.8	1.2	2.3	-0.4	-1.2	-1.5	-0.9
Age at First Birth	0.8	1.2	2.8	-1.4	-1.7	-0.1	0.1
Bipolar Disorder (2011)	0.8	0.8	3.3	0.0	0.0	0.0	-1.8
Body Mass Index (BMI) (2010)	0.7	1.0	2.9	0.1	0.2	1.0	1.7
Coronary Artery Disease (CAD)	0.7	0.9	2.3	0.4	0.9	1.5	-0.3
Crohns Disease (2012)	0.7	1.2	3.4	-0.8	1.8	0.7	-0.5
Mean Putamen Volume	0.1	0.1	0.4	0.3	-0.2	0.2	-0.6
Fasting Glucose	1.8	2.2	5.1	-1.2	2.3	0.7	1.3
HbA1C	0.2	0.2	0.4	0.5	0.4	0.2	-0.6
HDL Cholesterol	0.7	1.2	3.8	0.3	-1.9	-1.0	0.4
LDL Cholesterol	0.2	0.3	0.6	0.5	0.8	-0.5	-0.0
Lupus	0.1	0.1	0.4	-0.0	-0.6	-0.4	-0.0
Neuroticism (2016)	2.2	3.2	7.0	2.6	-0.1	-2.0	-1.3
Primary Biliary Cirrhosis	0.4	0.5	0.9	1.0	-0.3	-0.7	-0.8
Rheumatoid Arthritis	1.6	2.2	6.6	1.0	0.6	-0.8	-2.6
Schizophrenia (2014)	0.8	1.8	2.8	-0.8	-1.4	1.3	1.7
Triglycerides	1.0	1.6	2.8	1.4	-1.7	-1.1	0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	-1.0	1.0	0.3	-0.0
Ulcerative Colitis	0.2	0.3	0.6	0.5	-0.8	-0.6	-0.0
Blood Eosinophil Count	0.4	3.0	6.1	2.5	0.0	-1.0	-2.3
Blood Platelet Count	0.1	1.0	1.5	1.1	1.1	-1.2	-0.2
Blood Red Count	0.7	6.5	8.8	2.7	2.0	-3.0	-2.4
Blood White Count	0.4	3.2	4.7	1.4	1.4	-2.2	-2.0
Heel T-Score	0.7	5.5	9.1	-2.0	2.2	3.0	2.0
BMI	0.1	0.9	1.8	1.4	-1.1	0.6	0.1
Height	0.5	9.9	20.7	-1.4	4.5	3.9	-1.4
Waist Hip Ratio (WHR)	0.6	2.7	8.5	-0.4	-0.2	-2.9	-1.5
Systolic Blood Pressure	0.4	2.0	4.8	-0.4	-0.9	-2.2	1.4
Smoking Status	6.4	15.4	26.1	5.1	-0.9	-3.0	-5.1
Allergy or Eczema	0.3	0.7	1.4	0.9	-0.3	-0.7	1.2
Cardiovascular Disease	0.8	2.7	4.7	1.9	-2.2	-1.6	-0.2
Hypothyroidism (self reported)	0.4	1.0	1.7	1.1	-0.8	-0.5	-1.3
Respiratory disease	0.0	0.1	0.2	0.1	-0.3	-0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.3	0.0	0.3	-1.1	0.7
Lung FEV1/FVC ratio	1.4	7.3	15.5	-2.0	0.5	3.0	3.9
Lung FVC	0.3	1.5	3.6	-1.9	-0.3	1.0	1.2
Neuroticism	1.7	4.2	10.7	1.8	-1.1	-3.3	-1.3
Chronotype (morning person)	0.3	0.7	2.3	-0.5	-0.0	0.7	1.5
Hair Pigment	0.0	1.1	2.1	0.3	1.5	-1.5	-0.1
Tanning	0.2	2.0	7.0	-0.4	2.6	0.5	0.8
Hand grip strength (left)	1.2	3.1	8.4	0.5	2.9	1.0	-1.6
Number of treatments/medications taken	0.2	0.4	0.7	0.6	0.8	-0.4	0.4
Average weekly spirits intake	2.0	2.4	5.2	-1.5	0.4	1.5	2.3
Sensitivity / hurt feelings	1.1	1.8	3.5	0.7	-1.9	-1.8	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	0.5	-1.1	-1.1	0.2
Hearing difficulty/problems: Yes	0.6	0.9	1.7	-0.5	1.1	0.7	1.3
Relative age of first facial hair	1.3	2.6	7.6	1.0	-1.1	-0.8	-2.8
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	4.8	-1.5	1.2	2.1	2.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	0.2	0.5	0.8	1.0
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.2	0.2	0.1	0.2
Systolic blood pressure, automated reading	0.4	1.1	2.3	-0.8	-0.2	-1.2	1.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.9	1.4	0.2	-0.3	0.0
Angina	1.3	1.8	3.5	-1.9	1.0	1.4	0.7
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	0.4	0.2	-0.5
Vitamin and mineral supplements	1.1	1.5	1.7	1.3	-1.2	-1.2	-1.2
Supplements: Zinc	0.7	0.7	2.7	0.1	-0.5	-1.6	-0.1
Medication: Co-codamol	0.1	0.1	0.4	0.1	0.1	-0.6	-0.4
Medication: Metformin	0.6	0.9	2.2	0.3	1.5	-1.1	0.3
Diabetes (father)	0.5	0.6	1.2	-1.1	-0.4	0.3	1.0
Diabetes (mother)	0.3	0.4	1.1	-1.0	-0.7	0.4	0.2
Severe depression (siblings)	2.5	2.8	4.5	2.1	-1.9	-1.1	-1.4
Pack years adult smoking proportion	2.7	4.1	7.2	0.0	2.7	1.5	-2.6
Impedance of leg (right)	0.1	0.7	1.7	-0.9	0.4	-0.2	1.3
Leg fat-free mass (left)	0.2	1.1	1.9	0.9	0.4	1.4	-1.2
Trunk fat percentage	0.4	1.6	4.3	-0.7	-0.0	1.2	2.1
Hand grip strength (right)	0.9	2.3	5.8	0.0	2.4	1.5	-1.1
Townsend deprivation index at recruitment	1.1	1.6	4.2	1.0	-2.1	-1.0	-0.2
Current tobacco smoking	1.8	3.0	6.6	2.1	0.4	-0.8	-2.6
Average weekly fortified wine intake	0.6	0.7	1.9	-0.7	0.5	1.4	-0.4
Maternal smoking around birth	0.3	0.5	0.9	0.9	0.7	-0.2	-0.7
Fed-up feelings	0.2	0.4	1.4	1.2	-0.1	-0.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	0.8	0.2	-0.4	-1.2
Relative age voice broke	0.4	0.6	1.0	1.0	-0.7	-0.3	-0.8
Taking other prescription medications	0.4	0.6	1.1	1.0	1.1	0.0	0.3
Age when periods started (menarche)	2.2	5.2	7.8	-2.8	1.7	2.6	1.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.9	0.4	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.7	0.5	0.9	0.5
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.0	0.2	-1.6	-1.7	-0.0
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.2	-0.3	-0.5	0.4
Serious illness, injury or assault to yourself	0.8	0.9	3.2	0.2	1.8	-0.8	-0.0
High blood pressure	0.9	2.5	3.8	1.9	-1.9	-1.6	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	1.8	0.8	-1.1	-1.3	1.2
Multivitamins +/- minerals	3.5	4.4	6.6	-2.4	1.2	2.6	2.0
Stomach or abdominal pain in last month	0.1	0.2	0.6	-0.8	-0.0	-0.1	-0.2
Supplements: Glucosamine	0.4	0.5	0.9	0.0	0.8	0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	-0.5	1.4	0.4	0.3
Medication: Atenolol	0.4	0.6	2.0	-0.3	0.1	0.4	1.4
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.4
Sitting height	0.2	1.6	2.6	0.6	1.2	1.6	-1.5
Chronic bronchitis/emphysema (father)	2.7	3.2	4.5	1.8	-1.6	-2.1	-1.7
High blood pressure (mother)	0.4	0.6	1.7	-0.3	0.8	1.3	0.1
Body mass index (BMI)	0.1	0.5	1.4	1.2	-0.7	-0.4	0.0
Impedance of leg (left)	0.1	0.5	1.1	-0.7	0.1	-0.5	1.1
Leg predicted mass (left)	0.2	1.1	1.9	0.9	0.5	1.4	-1.2
Trunk fat mass	0.2	0.7	1.6	-0.0	0.1	1.1	1.3
Waist circumference	0.1	0.3	0.8	0.5	-0.1	-0.9	-0.6
Number of incorrect matches in round	4.1	6.9	8.5	-2.5	2.8	2.9	2.2
Past tobacco smoking	4.6	8.5	13.4	-3.7	1.5	3.1	3.0
Alcohol usually taken with meals	1.1	1.9	2.9	-1.4	1.4	1.7	0.9
Nervous feelings	0.4	0.8	2.8	0.3	0.3	-1.7	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	0.9	-0.8	-1.5	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	1.7	1.2	0.2	-1.3	-0.9
Hair/balding pattern: Pattern 2	0.9	1.1	3.0	-0.9	1.7	0.8	0.3
Had menopause	0.2	0.3	1.1	-0.1	0.0	0.0	1.0
Had other major operations	0.2	0.3	0.7	0.5	0.8	-0.3	0.2
Forced vital capacity (FVC)	0.2	0.9	3.5	0.1	-0.0	0.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-0.9	0.1	0.5	1.1
Ever unenthusiastic/disinterested for a whole week	3.9	4.8	8.3	1.9	-2.9	-2.4	-1.2
Qualifications: None of the above	1.4	3.1	7.5	-1.6	0.5	1.4	2.7
Financial difficulties in last 2 years	0.3	0.4	0.9	-0.2	-0.5	-1.0	-0.6
Mouth/teeth dental problems	0.3	0.5	1.1	-0.2	-0.6	1.1	0.8
Heart attack	2.5	3.2	5.2	-2.2	0.5	1.6	2.3
Allergy	0.3	0.6	1.2	-0.1	0.8	0.9	-1.1
Pain all over the body in last month	3.8	4.1	5.9	-1.8	1.7	2.4	2.0
Diabetes (self-reported)	0.6	0.9	1.0	-0.9	1.0	-0.7	1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.7	0.8	1.9	0.0	-0.4
Medication: Ramipril	0.3	0.4	0.9	-0.7	0.4	0.1	1.0
Medication: Simvastatin	0.4	0.7	1.8	-0.3	-0.9	-1.3	-0.1
Fluid intelligence score	0.7	1.5	3.7	0.2	-1.9	-1.4	-0.4
Illnesses of siblings	0.3	0.4	0.6	0.3	0.8	0.7	0.5
Neuroticism score	0.7	1.4	3.9	1.1	-0.4	-2.0	-0.6
Weight	0.1	0.7	1.9	1.4	0.4	0.6	-0.7
Impedance of arm (right)	1.3	6.3	10.8	-3.3	1.0	2.8	2.3
Arm fat percentage (right)	0.1	0.5	1.0	-0.2	-0.4	1.0	1.0
Trunk fat-free mass	0.5	2.7	5.3	1.9	1.1	0.6	-2.3
Hip circumference	0.1	0.5	1.7	1.3	-0.2	0.3	-0.6
Time employed in main current job	0.4	0.4	0.9	-0.9	0.3	0.9	0.2
Alcohol intake versus 10 years previously	0.5	0.7	1.4	-1.2	0.3	0.5	1.0
Father’s age at death	0.2	0.3	0.5	-0.6	-0.5	0.4	0.7
Worrier / anxious feelings	0.2	0.4	0.8	0.5	-0.9	-0.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	0.9	-0.6	-0.9	-1.2
Falls in the last year	0.7	1.0	3.0	-0.6	1.7	0.8	-0.1
Hair/balding pattern: Pattern 3	1.7	2.6	4.5	1.3	-2.1	-1.6	-1.2
Number of live births	2.0	2.8	6.2	-1.3	1.7	0.7	2.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.4	-0.4	0.2	1.2	-0.3
Pulse rate	0.7	1.1	3.3	0.8	1.8	0.7	0.0
Happiness	0.2	0.3	0.8	-0.5	0.9	-0.0	0.3
Noisy workplace	2.7	3.3	7.5	-0.6	2.7	2.1	1.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.2	0.1	-2.5	-1.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.4	-0.3	-0.2
Mouth/teeth dental problems: Dentures	1.0	1.8	5.8	-0.1	2.4	-0.9	-0.5
Asthma	0.2	0.3	0.7	0.7	-0.3	-0.8	-0.0
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	7.7	-1.7	1.8	2.8	1.3
Medication: Cholesterol lowering	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.1
Depression (self-reported)	0.4	0.4	1.4	0.0	-0.5	-1.2	-0.4
Medication: Lansoprazole	2.0	2.3	6.4	-1.4	2.5	0.1	0.9
Prospective memory result	0.8	0.9	2.5	0.0	0.8	1.6	-0.8
Lung cancer (father)	0.1	0.2	0.5	0.0	0.7	0.3	0.3
Illnesses of mother	0.6	0.7	2.4	-0.5	-0.4	0.1	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.8	-1.0	-0.2	1.3	0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.8	0.7	-0.0	-0.2
Impedance of arm (left)	1.2	5.4	9.9	-3.1	0.6	2.6	2.1
Arm fat mass (right)	0.0	0.2	0.5	0.3	-0.2	0.7	0.3
Trunk predicted mass	0.5	2.7	5.6	1.9	1.2	0.7	-2.4
Standing height	0.4	3.6	6.8	0.2	2.6	2.4	-1.4
Length of working week for main job	0.3	0.4	1.0	0.6	0.2	-0.1	-1.0
Exposure to tobacco smoke at home	0.4	0.5	1.2	-0.3	-0.2	-0.8	1.1
Breastfed as a baby	0.2	0.3	0.8	-0.1	0.3	-0.5	-0.9
Tense / ‘highly strung’	0.4	0.7	2.8	-0.0	1.7	-0.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	1.0	-0.4	-0.8	-0.3
Hair/balding pattern: Pattern 4	0.8	1.8	3.9	-2.0	0.4	1.8	-0.2
Birth weight of first child	3.2	5.7	7.5	2.7	-2.6	-2.0	-2.1
Peak expiratory flow (PEF)	0.7	1.6	4.3	-0.2	1.3	2.1	0.3
Pulse wave reflection index	0.8	1.0	1.5	0.9	-0.6	-1.2	-1.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.3	1.2	-2.1	0.0	-1.1
Loud music exposure frequency	4.7	5.1	5.6	2.4	-2.1	-2.2	-2.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.9	1.0	-1.7	-0.1	-1.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.7	0.7	-1.8	-0.9	-1.9
Blood clot in the leg (DVT)	2.7	3.5	7.1	-2.7	0.8	1.5	2.0
Medication: Paracetamol	0.9	1.5	3.4	-1.8	1.0	0.7	1.0
Headache pain in last month	0.4	0.7	1.3	-0.4	1.1	1.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	-0.4	1.1	0.2	-0.8
Glaucoma (self-reported)	1.7	2.0	3.2	1.6	-0.3	-1.8	-1.5
Gout (self-reported)	0.5	0.7	1.7	1.3	-0.9	-0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	0.9	0.9	-0.8	-1.0	-0.9
Medication: Amlodipine	0.4	0.6	1.3	0.8	-0.7	-1.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.2	0.7	-0.6	-0.5
Birth weight	1.1	2.3	6.2	-0.5	-1.6	-0.7	-2.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.6	-0.8	0.0	-0.4
High blood pressure (siblings)	1.3	1.8	4.0	-2.0	-1.1	0.5	1.3
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-0.8	0.1	0.9	-0.7
Body fat percentage	0.2	0.8	3.0	-0.2	-0.2	0.5	1.7
Leg fat percentage (right)	0.2	0.7	1.2	0.7	-0.7	-1.1	0.8
Arm fat-free mass (right)	0.3	1.7	4.0	2.0	0.7	-0.1	-1.5
Exposure to tobacco smoke outside home	2.8	3.7	8.7	2.0	1.5	0.2	-2.9
Comparative body size at age 10	0.2	0.5	1.0	0.5	-1.0	-0.1	0.8
Number of full brothers	0.2	0.2	0.4	0.4	-0.2	-0.6	-0.6
Worry too long after embarrassment	0.5	0.8	2.2	0.3	0.2	-1.1	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.3	0.3	-0.7	0.2
Wheeze or whistling in the chest in last year	2.2	3.9	5.0	2.2	-1.4	-2.0	-2.2
Number of children fathered	3.0	3.4	5.7	-1.3	2.4	1.8	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.6	-1.2	-0.2	1.0
Age at first live birth	0.2	0.3	0.6	-0.3	-0.4	-0.8	0.5
Pulse wave peak to peak time	0.2	0.3	0.7	-0.8	-0.6	0.3	0.1
Health satisfaction	2.2	2.8	4.2	2.0	-0.8	-2.0	-1.6
Shortness of breath walking on level ground	0.6	0.7	1.4	1.2	0.7	0.4	-0.8
Qualifications: College or University degree	0.3	0.8	1.8	0.6	-0.4	-1.1	-1.3
Eye problems/disorders: None of the above	0.9	1.1	3.6	-0.7	0.4	1.9	0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	1.3	-0.7	-0.0	-0.6
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.0	0.2	0.2	-0.2
Medication for pain relief, constipation, heartburn	1.2	2.1	3.2	1.4	-1.5	-1.8	-1.0
Neck or shoulder pain in last month	0.2	0.3	0.9	0.9	0.2	-0.6	-0.2
Medication: Blood pressure	0.7	1.2	2.5	1.1	-1.6	-1.0	-0.0
Angina (self-reported)	1.0	1.3	2.1	-1.5	1.2	1.3	0.5
Migraine (self-reported)	2.0	2.5	3.6	1.8	-1.2	-1.2	-1.9
Medication: Ibuprofen	2.0	2.3	3.0	-1.5	1.3	1.7	1.5
Medication: Allopurinol	0.5	0.7	1.1	1.0	-0.5	-1.0	-0.6
Medication: Omeprazole	1.0	1.2	2.8	1.7	-0.1	-0.9	-1.0
Medication: Seretide 50 evohaler	1.6	1.8	4.5	1.4	-0.4	-2.1	-0.8
Mean time to correctly identify matches	0.2	0.3	0.5	-0.1	-0.5	-0.7	-0.7
Heart disease (mother)	1.9	2.3	5.4	-1.5	2.3	1.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.9	1.2	1.7	0.4	-1.0
Whole body fat mass	0.1	0.5	1.1	0.2	-0.1	0.9	1.1
Leg fat mass (right)	0.1	0.2	0.6	0.7	-0.3	-0.3	0.3
Arm predicted mass (right)	0.3	1.8	4.2	2.1	0.5	-0.2	-1.6
Pulse rate, automated reading	0.4	1.2	2.2	1.5	-0.8	-1.3	-0.6
Alcohol intake frequency.	1.4	3.2	5.3	-2.3	0.5	1.4	2.3
Comparative height size at age 10	0.5	2.6	6.2	0.0	2.5	2.0	0.5
Number of full sisters	0.6	0.8	1.7	1.3	0.6	1.0	-0.3
Suffer from ‘nerves’	0.3	0.5	1.4	-0.1	1.2	0.2	0.7
Overall health rating	0.9	2.0	3.2	1.8	-1.4	-1.2	-1.1
Chest pain or discomfort	0.3	0.5	1.5	0.2	1.2	0.1	-0.6
Had major operations	0.6	0.7	2.0	-0.5	-0.7	-0.2	1.4
Age at last live birth	0.9	1.3	3.6	-1.9	0.2	0.7	1.0
Family relationship satisfaction	2.1	2.5	4.8	1.2	-1.9	-2.2	-0.4
Leg pain on walking	0.2	0.3	0.5	0.7	-0.4	-0.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.2	1.0	-1.5	-0.1	-1.1
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.9	-2.4	1.3	1.7	1.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.4	-0.7	0.2	-0.4
Medication: Aspirin	0.5	0.6	1.8	-0.5	1.3	0.5	-0.4
Supplements: Vitamin C	0.8	0.9	1.6	-1.3	1.0	0.5	0.9
Knee pain experienced in last month	1.7	2.6	4.9	1.0	-0.7	-2.2	-2.0
Hypertension (Self-reported)	0.9	2.6	4.4	2.1	-1.9	-1.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	4.0	0.3	2.0	0.1	-0.1
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.8	1.0	0.6	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.9	-0.3	-0.7	-0.7
Smoking status: Previous	3.8	5.6	8.4	2.9	-1.4	-2.6	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.5	0.4	1.5	1.2	-1.6
Whole body fat-free mass	0.4	2.0	3.8	1.7	0.8	0.8	-1.9
Leg fat-free mass (right)	0.3	1.4	2.6	1.3	0.4	1.2	-1.6
Arm fat percentage (left)	0.1	0.5	1.0	-0.2	-0.5	0.8	1.0
Average weekly red wine intake	0.9	1.3	3.0	-1.7	0.0	1.0	1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.9	-0.1	0.8	1.4	0.9
Mood swings	0.3	0.5	1.2	-0.2	-0.3	-1.1	0.8
Loneliness, isolation	0.7	0.9	3.6	0.3	-0.2	-1.9	0.1
Long-standing illness, disability or infirmity	1.0	1.5	3.3	1.8	1.1	-1.1	-0.8
Ever had bowel cancer screening	1.7	2.0	5.3	-2.3	0.6	1.4	0.5
Diabetes diagnosed by doctor	0.4	0.7	1.2	-0.4	1.1	-0.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.8	1.7	0.2	-0.9	-1.6
Friendships satisfaction	0.2	0.3	0.5	0.5	-0.6	-0.7	-0.1
Qualifications: nursing, teaching	0.1	0.1	0.3	0.0	0.5	0.0	-0.3
Commuting to job workplace: Walk	1.2	1.3	3.4	1.8	-1.2	-0.1	-0.6
Eye problems/disorders: Cataract	0.4	0.4	0.7	-0.7	0.6	-0.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.1	-1.4	1.2	1.4	0.2
Medication for cholesterol	0.6	0.9	2.8	0.2	-0.0	1.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.2	-0.3	1.1	1.8	0.1
Back pain experienced in last month	0.6	0.9	1.8	0.5	1.4	-0.4	-1.2
Mineral and other dietary supplements	1.0	1.3	2.0	1.4	-1.4	-0.5	-1.1
Breast cancer (self-reported)	1.2	1.5	1.9	1.2	-1.4	-1.3	-0.9
Asthma (self-reported)	0.2	0.4	0.7	0.8	-0.3	-0.8	-0.0
Osteoporosis (self-reported)	1.9	2.4	5.4	1.4	-0.2	-2.3	-1.5
Osteoarthritis (self-reported)	3.4	4.4	10.4	1.9	0.8	-1.7	-3.2
Medication: Aspirin	0.5	0.6	1.7	-0.8	1.3	0.4	0.0
Medication: Gliclazide	1.9	2.1	3.0	1.7	-0.2	-1.6	-1.7
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	-1.0	0.6	1.2	0.9
Smoking status: Current	1.5	2.3	5.1	1.9	0.4	-0.6	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.8	-0.9	0.1	0.0	0.7
Whole body water mass	0.3	1.7	3.3	1.5	0.8	0.8	-1.8
Leg predicted mass (right)	0.3	1.5	2.6	1.3	0.4	1.2	-1.6
Arm fat mass (left)	0.1	0.2	0.5	0.5	-0.4	0.7	0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.4	1.2	-0.0	-1.0	-0.1
Average weekly champagne plus white wine intake	0.6	0.8	2.2	0.7	0.5	0.4	-1.5
Miserableness	2.2	3.8	5.4	2.3	-1.7	-2.3	-1.3
Guilty feelings	2.1	3.1	6.4	2.5	-0.6	-0.6	-2.3
Wears glasses or contact lenses	1.3	1.5	3.5	-1.3	0.1	0.9	1.9
Ever taken oral contraceptive pill	0.6	0.7	1.8	1.0	-0.1	1.3	-0.1
Hearing aid user	0.8	0.9	2.1	-0.7	0.7	0.6	1.4
Mother’s age at death	0.3	0.4	1.4	-0.1	0.1	-0.2	-1.2
Financial situation satisfaction	1.0	1.3	2.9	0.9	-0.6	-1.7	-1.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.3	0.9	-0.4	-0.2
Commuting to job workplace: Public transport	1.1	1.3	1.7	1.3	-1.1	-1.3	-0.7
Eye problems/disorders: Glaucoma	1.0	1.1	2.3	1.2	0.2	-1.5	-1.0
Medication: Blood pressure	0.5	1.0	2.3	-0.4	-0.4	-1.1	1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.5	-0.7	1.9	0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.3	-1.1	0.8	-0.0	1.0
High cholesterol (Self-reported)	0.6	1.0	3.1	0.3	0.2	-0.9	-1.8
Medication: Bendroflumethiazide	0.6	0.9	3.0	0.5	-0.0	-0.7	1.7
Medication: Paracetamol	0.3	0.5	1.1	-0.9	1.0	-0.2	-0.1
Medication: Lisinopril	1.6	2.1	4.3	0.8	-2.1	-1.9	-0.3
Medication: Atorvastatin	0.3	0.3	1.0	-0.2	0.5	-1.0	0.0
Illnesses of father: High blood pressure	0.4	0.6	1.0	1.0	-0.8	0.1	-0.8
Alcohol drinker status: Never	0.5	0.5	1.5	0.4	0.6	1.2	0.4
Ever smoked	4.4	7.7	10.6	3.3	-1.5	-3.0	-2.9
Basal metabolic rate	0.3	1.5	2.7	1.5	0.7	0.9	-1.6
Leg fat percentage (left)	0.2	0.8	1.6	0.8	-0.8	-1.3	0.6
Arm fat-free mass (left)	0.3	1.6	3.4	1.8	0.6	0.1	-1.7
Number of operations (self-reported)	0.1	0.1	0.2	0.3	0.2	-0.4	0.2
Average weekly beer plus cider intake	2.0	2.9	3.5	1.9	-1.5	-1.7	-1.8
Irritability	1.1	1.9	4.1	1.4	-0.9	-2.0	-0.8
Risk taking	0.6	0.9	1.7	-1.3	1.2	0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.1	-0.1	0.5	-0.5
Fractured/broken bones in last 5 years	1.7	2.2	4.8	-2.2	1.4	0.9	1.2
Age started oral contraceptive pill	0.4	0.5	1.5	-0.5	1.2	-0.1	-0.0
Diastolic blood pressure, automated reading	0.7	2.2	3.4	0.9	-1.8	-1.8	1.1
Ever depressed for a whole week	3.8	4.7	13.1	1.8	-3.6	-1.6	0.3
Unable to work because of sickness or disability	0.9	1.1	3.2	-0.9	0.5	0.5	1.8
Commuting to job workplace: Cycle	1.0	1.1	3.0	0.9	1.7	-0.2	-0.8
Myopia	1.1	1.6	4.0	-0.4	-0.3	2.0	1.5
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.6	-1.3	2.1	1.6	-0.4
Cholesterol lowering medication	1.3	2.0	7.0	0.3	-0.3	-2.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	0.6	0.4	-0.4	-0.6
Pain experienced in last month	0.2	0.4	0.7	0.9	-0.8	-0.4	0.0
Supplements: Calcium	1.0	1.1	3.1	-1.8	0.1	-1.1	0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	0.9	1.2	0.0	-0.7
Heart attack/myocardial infarction (self-reported)	3.2	4.1	6.7	-2.4	0.6	1.9	2.6
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	7.4	-2.7	0.6	1.5	2.4
Heart disease (siblings)	0.1	0.1	0.2	0.1	-0.5	-0.1	-0.4
Alcohol drinker status: Previous	0.3	0.4	0.9	0.0	0.4	-0.9	0.7
Pack years of smoking	2.5	3.6	6.9	-0.2	2.6	1.4	-2.3
Impedance of whole body	0.5	2.8	5.0	-2.2	0.7	1.4	1.9
Leg fat mass (left)	0.1	0.2	0.5	0.7	-0.4	-0.3	0.3
Arm predicted mass (left)	0.4	2.1	4.0	2.0	0.7	-0.2	-2.0