Hub : Genes

CMKLR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0200	2.4e-02	0.027	0.001	0.015	0.009	0.030	2.4e-04	2.7e-01	5.3e-03	2.3e-02	1.4e-04
2	YFS	Blood	0.0961	0.0218	3.6e-15	0.050	0.064	0.073	0.070	0.071	5.7e-16	4.0e-20	7.4e-23	6.5e-22	2.9e-22
3	TCGA	Stomach Adenocarcinoma	0.1580	0.0690	4.0e-03	-0.002	0.047	0.034	NA	0.010	5.4e-01	2.5e-04	1.6e-03	NA	5.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.8	-0.1	1.3	-0.5
Bipolar Disorder or Schizophrenia	0.4	0.9	2.5	0.3	1.6	0.1
Depressed Affect (Nagel 2018)	0.3	0.5	1.6	0.1	0.1	1.3
Depression (Nagel 2018)	0.6	0.9	2.0	-0.7	-1.4	-0.5
Intelligence (Savage-Jansen 2018)	0.8	2.6	3.8	-1.8	-1.9	0.8
Neuroticism (Nagel 2018)	0.6	1.4	2.3	-1.1	-0.9	1.5
Schizophrenia (2018)	0.2	0.5	0.9	0.4	1.0	0.5
Schizophrenia vs Biploar Disorder	0.8	1.1	1.6	-1.0	-1.3	0.9
Worry (Nagel 2018)	1.2	2.6	4.2	-1.2	-1.5	2.0
Alzheimer’s Disease (in mother)	0.5	0.6	0.7	-0.6	-0.7	-0.9
Alzheimer’s Disease (in father)	0.9	1.0	1.7	-1.1	0.3	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.9	-0.2	-0.6
Crohns Disease (2017)	0.6	1.4	4.0	0.4	0.3	-2.0
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	0.8	0.9	-1.9
Ulcerative Colitis (UC)	0.4	0.8	1.0	0.9	1.0	-0.8
Major Depression (MDD)	0.2	0.3	0.5	0.5	0.7	0.1
Reaction Time	0.1	0.1	0.4	-0.1	0.6	-0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.9	-1.1	-1.4	0.7
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.2	0.4	-0.1	-0.7	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	3.2	-0.1	-0.9	1.8
Bipolar Disorder (2011)	2.9	2.8	5.5	0.7	2.3	-1.6
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.0	-0.7	0.4
Coronary Artery Disease (CAD)	0.7	0.8	1.1	-1.0	-0.6	-1.1
Crohns Disease (2012)	0.7	1.2	3.2	0.5	-0.3	-1.8
Mean Putamen Volume	0.5	0.6	0.9	0.6	-0.7	0.9
Fasting Glucose	0.2	0.2	0.7	-0.8	-0.1	-0.1
HbA1C	1.0	1.2	2.7	-1.6	0.9	-0.2
HDL Cholesterol	0.6	1.0	2.5	0.0	-0.7	1.6
LDL Cholesterol	0.2	0.3	0.5	0.0	0.7	-0.6
Lupus	0.0	0.0	0.1	-0.1	0.1	-0.3
Neuroticism (2016)	0.5	0.7	1.4	-1.2	-0.0	-0.8
Primary Biliary Cirrhosis	2.4	3.4	5.1	0.7	2.2	-2.2
Rheumatoid Arthritis	0.4	0.5	0.5	-0.7	0.7	-0.7
Schizophrenia (2014)	0.1	0.3	0.9	0.1	0.9	0.0
Triglycerides	0.1	0.2	0.4	0.2	0.5	-0.6
Type 2 Diabetes (T2D) (2012)	1.7	1.9	2.1	-1.2	-1.5	-1.4
Ulcerative Colitis	1.2	1.8	2.3	1.5	1.2	-1.2
Blood Eosinophil Count	0.3	2.5	4.5	-0.5	1.6	-2.1
Blood Platelet Count	0.3	3.9	5.8	1.1	-2.4	2.2
Blood Red Count	0.1	1.2	2.5	1.0	1.6	0.0
Blood White Count	0.1	0.9	1.4	-1.2	-0.8	0.7
Heel T-Score	0.6	4.9	9.1	1.9	3.0	1.4
BMI	0.4	2.3	6.1	0.0	0.8	-2.5
Height	1.2	23.2	29.2	4.9	5.4	-4.0
Waist Hip Ratio (WHR)	0.7	2.9	5.4	0.5	1.8	-2.3
Systolic Blood Pressure	0.1	0.6	0.9	-0.7	0.6	1.0
Smoking Status	0.5	1.2	1.5	-1.2	-1.2	0.8
Allergy or Eczema	0.4	1.0	2.1	0.4	1.4	-0.8
Cardiovascular Disease	0.9	3.0	4.6	-2.0	-0.8	-2.1
Hypothyroidism (self reported)	0.1	0.1	0.4	0.2	-0.6	-0.1
Respiratory disease	0.2	0.4	1.0	-0.5	1.0	-0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.9	1.7	0.4	-1.1
Lung FEV1/FVC ratio	0.2	1.1	1.3	-1.1	-1.2	-0.9
Lung FVC	0.8	3.9	4.6	-2.1	-1.8	2.0
Neuroticism	0.7	1.8	3.1	-1.4	-1.8	0.3
Chronotype (morning person)	1.6	3.7	6.6	2.6	1.3	1.7
Hair Pigment	0.1	3.3	5.0	-2.2	-2.0	-1.0
Tanning	0.1	1.2	1.6	0.7	1.3	1.2
Hand grip strength (left)	0.5	1.3	2.4	1.2	1.6	-0.2
Number of treatments/medications taken	1.4	2.4	4.3	-0.8	-1.6	-2.1
Average weekly spirits intake	0.3	0.4	0.7	0.6	-0.9	-0.0
Sensitivity / hurt feelings	0.2	0.3	0.5	-0.7	-0.2	-0.5
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.2	-0.4	-0.7	-1.1
Hearing difficulty/problems: Yes	1.1	1.6	4.8	-0.4	0.2	-2.2
Relative age of first facial hair	1.0	2.1	3.6	-1.9	-1.6	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.0	-1.1	-1.4	-0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.4	-1.2	-1.5	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.3	0.2	-0.5
Systolic blood pressure, automated reading	0.3	0.8	1.3	0.5	1.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	-0.2	-1.4	-0.1
Angina	0.4	0.5	0.8	0.0	-0.9	-0.8
Medication for hormone replacement therapy	0.6	0.7	1.2	-1.1	-0.9	-0.4
Vitamin and mineral supplements	1.0	1.4	2.3	1.5	1.2	-0.6
Supplements: Zinc	0.8	0.9	1.6	-0.9	-1.3	0.3
Medication: Co-codamol	1.3	1.5	2.1	-1.4	-1.1	-1.1
Medication: Metformin	0.2	0.3	0.6	-0.3	-0.7	-0.4
Diabetes (father)	0.3	0.3	0.6	-0.8	-0.6	-0.1
Diabetes (mother)	0.7	0.8	2.0	-0.3	0.7	-1.4
Severe depression (siblings)	0.4	0.5	1.2	0.2	1.1	0.5
Pack years adult smoking proportion	1.1	1.8	2.8	0.4	1.7	-1.5
Impedance of leg (right)	1.2	5.9	9.4	2.9	3.1	-0.2
Leg fat-free mass (left)	0.3	1.7	5.0	-0.3	0.1	-2.2
Trunk fat percentage	0.3	1.2	1.6	0.9	1.1	-1.3
Hand grip strength (right)	0.9	2.4	4.5	1.7	2.1	0.1
Townsend deprivation index at recruitment	1.0	1.4	2.0	-1.4	-1.4	0.5
Current tobacco smoking	0.0	0.1	0.1	-0.2	0.3	0.3
Average weekly fortified wine intake	0.2	0.2	0.4	-0.1	0.5	-0.6
Maternal smoking around birth	0.5	0.7	2.0	0.0	0.4	-1.4
Fed-up feelings	0.1	0.1	0.2	-0.3	-0.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.4	-0.2	-1.2	-0.6
Relative age voice broke	0.6	1.0	1.7	-1.3	-1.0	-0.3
Taking other prescription medications	0.8	1.3	3.5	0.6	-0.2	-1.9
Age when periods started (menarche)	0.8	2.0	4.0	-0.6	1.3	2.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.5	0.6	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.1	0.5	1.8	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.3	0.6	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.7	-0.7	0.6	-1.3
Serious illness, injury or assault to yourself	0.3	0.3	0.6	0.4	-0.8	-0.5
High blood pressure	1.1	3.2	5.8	-2.4	-0.7	-1.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	0.4	1.0	-0.5
Multivitamins +/- minerals	0.8	1.0	1.6	-1.3	-1.2	0.2
Stomach or abdominal pain in last month	0.4	0.5	1.3	-0.5	-0.2	-1.1
Supplements: Glucosamine	4.7	6.1	10.1	-2.7	-3.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.3	-1.2	-1.0	-0.8
Medication: Atenolol	1.6	2.0	3.0	-1.7	-1.7	-0.4
Medication: Levothyroxine sodium	0.6	1.1	2.8	-0.2	-0.6	-1.7
Sitting height	0.1	0.9	2.1	-0.2	0.7	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	0.1	0.5	-1.0
High blood pressure (mother)	0.2	0.3	0.5	-0.5	0.3	-0.7
Body mass index (BMI)	0.3	1.4	3.0	-0.9	-0.6	-1.7
Impedance of leg (left)	0.9	4.5	7.8	2.4	2.8	0.3
Leg predicted mass (left)	0.3	1.8	5.4	-0.3	0.1	-2.3
Trunk fat mass	0.6	2.5	4.7	1.1	1.3	-2.2
Waist circumference	0.8	2.8	7.1	0.5	1.0	-2.7
Number of incorrect matches in round	0.0	0.1	0.1	-0.3	0.0	-0.2
Past tobacco smoking	2.0	3.6	5.2	1.9	2.3	-1.5
Alcohol usually taken with meals	0.3	0.5	1.2	-0.0	1.1	0.6
Nervous feelings	1.4	2.7	3.4	-1.6	-1.8	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.5	-0.7	-1.9	0.5
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.1	-0.1	-1.1
Hair/balding pattern: Pattern 2	1.2	1.6	2.3	1.5	0.6	1.4
Had menopause	0.3	0.4	0.8	0.6	-0.1	0.9
Had other major operations	0.4	0.5	1.1	0.1	-1.1	-0.6
Forced vital capacity (FVC)	0.1	0.6	1.3	-1.1	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.8	0.3	1.7	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	-0.1	0.7	-0.5
Qualifications: None of the above	0.5	1.0	3.1	-0.0	0.1	-1.8
Financial difficulties in last 2 years	0.1	0.2	0.5	0.3	0.0	-0.7
Mouth/teeth dental problems	1.0	1.6	3.0	1.3	-0.2	1.7
Heart attack	1.7	2.2	4.9	-1.2	-2.2	0.6
Allergy	0.5	1.1	1.8	-0.7	-1.3	1.1
Pain all over the body in last month	3.5	3.8	5.4	-1.3	-2.3	2.0
Diabetes (self-reported)	0.6	1.0	2.3	0.7	0.4	-1.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.3	1.0	-0.0	1.5
Medication: Ramipril	1.6	2.1	3.4	-1.8	-1.4	-1.0
Medication: Simvastatin	0.4	0.6	1.6	-0.1	0.1	-1.3
Fluid intelligence score	0.4	0.9	1.9	-0.4	-1.4	0.8
Illnesses of siblings	1.6	2.3	6.7	-0.1	-0.5	2.6
Neuroticism score	0.9	2.0	3.0	-1.5	-1.7	0.7
Weight	0.6	2.9	8.2	0.3	0.7	-2.9
Impedance of arm (right)	0.6	3.0	4.7	1.7	1.2	2.2
Arm fat percentage (right)	0.1	0.3	1.0	0.1	0.2	-1.0
Trunk fat-free mass	0.5	2.6	7.6	-0.2	0.5	-2.8
Hip circumference	0.3	1.5	4.3	0.3	0.2	-2.1
Time employed in main current job	1.1	1.2	2.5	1.0	1.6	-0.5
Alcohol intake versus 10 years previously	0.9	1.4	3.0	1.7	1.0	-0.4
Father’s age at death	1.5	2.0	3.4	1.9	1.6	-0.1
Worrier / anxious feelings	1.9	3.5	7.6	-1.1	-2.8	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	2.9	-0.9	-1.7	-0.6
Falls in the last year	2.6	3.5	5.6	-2.4	-1.8	-1.3
Hair/balding pattern: Pattern 3	2.2	3.2	6.2	-2.5	-1.7	-0.8
Number of live births	0.3	0.4	0.5	-0.7	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	-1.2	-0.8	-0.2
Pulse rate	0.9	1.5	4.2	2.0	0.4	-0.4
Happiness	0.9	1.1	1.6	-0.1	-1.3	-1.3
Noisy workplace	2.2	2.7	5.5	-1.6	-2.4	0.2
Qualifications: A levels/AS levels or equivalent	2.1	4.6	8.6	-1.0	-2.0	2.9
Serious illness, injury or assault of a close relative in last 2 years	4.0	4.6	6.6	-1.8	-2.6	2.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.0	-0.4	-1.0
Asthma	0.2	0.3	1.0	-0.0	1.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.1	-1.0	-1.0	0.6
Medication: Cholesterol lowering	0.5	0.7	0.9	-0.9	-0.9	-0.7
Depression (self-reported)	0.4	0.5	1.1	0.5	0.1	-1.0
Medication: Lansoprazole	1.2	1.3	2.8	-1.1	-1.7	-0.2
Prospective memory result	1.6	2.0	3.5	1.4	1.9	0.7
Lung cancer (father)	0.5	0.6	1.1	-0.8	0.5	-1.0
Illnesses of mother	0.3	0.4	0.7	-0.0	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.6	-1.6	-1.1	0.2
Pulse wave Arterial Stiffness index	2.3	2.7	4.4	-1.9	-2.1	-0.2
Impedance of arm (left)	0.7	3.1	4.7	1.6	1.5	2.2
Arm fat mass (right)	0.3	1.2	3.3	0.3	0.5	-1.8
Trunk predicted mass	0.4	2.6	7.3	-0.1	0.6	-2.7
Standing height	0.8	8.3	10.1	2.8	3.2	-2.6
Length of working week for main job	0.9	1.0	2.1	0.7	1.5	-0.7
Exposure to tobacco smoke at home	1.4	1.6	2.2	1.1	1.5	-1.1
Breastfed as a baby	1.2	1.5	2.7	-1.1	-1.6	0.8
Tense / ‘highly strung’	0.9	1.5	3.2	-1.8	-0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	4.5	-1.4	-0.4	-2.1
Hair/balding pattern: Pattern 4	2.0	4.8	8.9	-2.3	-3.0	-0.3
Birth weight of first child	0.4	0.8	1.8	0.4	0.6	-1.3
Peak expiratory flow (PEF)	0.6	1.3	1.9	-1.4	-0.6	-1.3
Pulse wave reflection index	3.2	4.0	7.8	-2.8	-1.8	0.9
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	-0.8	-0.5	-0.3
Loud music exposure frequency	0.4	0.4	0.7	0.7	0.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.5	-0.6	-1.1	1.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	3.6	-1.9	-0.3	-0.1
Blood clot in the leg (DVT)	1.1	1.5	2.3	0.6	1.3	-1.5
Medication: Paracetamol	1.4	2.4	4.0	-2.0	-1.4	-1.1
Headache pain in last month	0.1	0.2	0.5	-0.4	-0.0	-0.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	1.6	0.7	1.0
Glaucoma (self-reported)	0.2	0.2	0.4	-0.4	-0.1	0.7
Gout (self-reported)	0.4	0.6	1.6	-0.3	0.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.4	-0.8	-1.6	-0.3
Medication: Amlodipine	1.0	1.3	2.2	-1.0	-1.5	-0.9
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.5	-0.1	0.2	1.6
Birth weight	0.4	0.8	1.4	1.2	0.5	-0.9
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	-0.1	-0.3	-0.1
High blood pressure (siblings)	1.5	2.2	5.2	-1.1	0.1	-2.3
Forced vital capacity (FVC), Best measure	0.2	0.8	2.1	-1.4	-0.7	0.1
Body fat percentage	0.5	1.8	3.5	0.9	1.0	-1.9
Leg fat percentage (right)	1.1	3.9	9.0	0.9	1.4	-3.0
Arm fat-free mass (right)	0.7	3.5	10.3	0.0	0.5	-3.2
Exposure to tobacco smoke outside home	0.5	0.6	1.9	-0.0	0.2	-1.4
Comparative body size at age 10	2.7	7.3	12.6	-2.2	-2.1	3.5
Number of full brothers	0.5	0.6	1.3	1.2	0.7	0.1
Worry too long after embarrassment	1.3	2.3	3.8	-1.5	-2.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.8	0.6	1.1	-2.4
Wheeze or whistling in the chest in last year	0.9	1.5	3.7	0.7	1.9	-0.6
Number of children fathered	0.9	1.0	2.1	1.4	0.9	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.6	0.3	-0.2
Age at first live birth	0.8	1.4	3.8	-0.4	-0.5	1.9
Pulse wave peak to peak time	3.2	3.8	6.2	2.3	2.5	-0.2
Health satisfaction	1.1	1.4	3.9	-0.6	-2.0	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.3	-0.2	-0.6
Qualifications: College or University degree	0.8	2.5	4.6	2.1	1.6	0.3
Eye problems/disorders: None of the above	0.3	0.3	1.0	0.1	1.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	0.1	0.9	-1.3
Emphysema/chronic bronchitis	0.5	0.6	1.7	-1.3	0.1	-0.1
Medication for pain relief, constipation, heartburn	1.1	1.9	3.4	1.8	1.2	0.9
Neck or shoulder pain in last month	1.2	1.6	4.5	-0.2	-0.6	-2.1
Medication: Blood pressure	0.7	1.3	3.4	-1.9	-0.7	-0.1
Angina (self-reported)	0.4	0.5	1.0	0.3	-0.7	-1.0
Migraine (self-reported)	1.9	2.3	4.7	2.2	0.7	-1.4
Medication: Ibuprofen	0.4	0.5	1.1	-0.4	-1.0	0.6
Medication: Allopurinol	0.4	0.5	1.4	-0.3	0.1	-1.2
Medication: Omeprazole	0.3	0.3	0.7	-0.3	0.3	-0.8
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.3	-0.1	-0.2
Mean time to correctly identify matches	0.1	0.3	0.4	0.4	0.6	0.6
Heart disease (mother)	0.8	1.0	2.4	0.5	-0.4	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.3	0.7	1.8	0.2
Whole body fat mass	0.6	2.6	5.9	0.7	1.1	-2.4
Leg fat mass (right)	1.2	4.5	11.3	0.6	1.3	-3.4
Arm predicted mass (right)	0.7	3.6	10.3	0.1	0.7	-3.2
Pulse rate, automated reading	0.3	0.8	2.4	1.6	0.0	-0.1
Alcohol intake frequency.	0.6	1.3	3.3	-0.4	0.7	-1.8
Comparative height size at age 10	2.0	10.8	12.7	3.6	2.9	-3.4
Number of full sisters	0.1	0.1	0.2	0.3	0.3	-0.5
Suffer from ‘nerves’	0.9	1.4	2.0	-1.0	-1.4	1.0
Overall health rating	1.3	2.7	4.2	-1.6	-2.1	-1.2
Chest pain or discomfort	0.3	0.5	1.0	-0.1	-1.0	0.6
Had major operations	0.4	0.5	1.1	0.4	-0.5	1.1
Age at last live birth	0.7	1.0	2.2	-1.0	-0.1	1.5
Family relationship satisfaction	2.2	2.7	5.9	0.9	1.2	-2.4
Leg pain on walking	0.5	0.6	0.9	-0.3	-0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-0.1	0.9	-1.0
Commuting to job workplace: Car/motor vehicle	2.8	3.2	8.6	-0.9	0.5	-2.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	3.6	1.9	0.9	-0.4
Medication: Aspirin	1.0	1.3	1.9	-1.4	-1.4	0.3
Supplements: Vitamin C	0.3	0.3	0.7	-0.6	-0.1	0.8
Knee pain experienced in last month	2.5	3.9	5.6	1.9	1.5	-2.4
Hypertension (Self-reported)	1.0	2.9	4.4	-2.1	-0.5	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	-0.2	-0.3	-0.8
Illnesses of father: Heart disease	1.9	2.6	5.5	-1.6	-2.3	0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.1	0.9	0.6	-1.1
Smoking status: Previous	0.7	1.0	1.5	-1.2	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	0.6	0.6	-0.4
Whole body fat-free mass	0.4	2.2	6.5	-0.2	0.3	-2.5
Leg fat-free mass (right)	0.2	1.3	3.4	-0.6	-0.2	-1.9
Arm fat percentage (left)	0.1	0.4	1.2	0.1	0.3	-1.1
Average weekly red wine intake	1.2	1.7	2.9	-1.2	-0.9	1.7
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.5	-1.1	-1.2	-0.8
Mood swings	0.2	0.3	0.5	-0.6	-0.7	0.4
Loneliness, isolation	1.5	2.1	2.9	1.6	1.7	-1.0
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.8	-0.1	-0.4
Ever had bowel cancer screening	0.6	0.7	1.6	-0.5	-0.3	-1.3
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.4	-0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	2.6	1.6	1.0	-0.7
Friendships satisfaction	0.9	1.1	2.0	-0.8	-0.8	-1.4
Qualifications: nursing, teaching	0.3	0.4	0.9	0.5	0.4	0.9
Commuting to job workplace: Walk	1.4	1.6	3.3	1.2	1.8	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.3	-0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.1	1.0	-0.3
Medication for cholesterol	0.8	1.2	2.3	0.9	0.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	2.2	1.1	1.5	-1.3
Back pain experienced in last month	2.0	2.9	5.4	0.5	1.7	-2.3
Mineral and other dietary supplements	3.3	4.4	8.2	1.6	2.9	-1.6
Breast cancer (self-reported)	0.3	0.4	1.0	1.0	-0.2	0.4
Asthma (self-reported)	0.2	0.5	1.4	-0.1	1.2	-0.2
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.1	-0.2	-1.4
Osteoarthritis (self-reported)	0.6	0.8	1.9	0.1	-0.6	-1.4
Medication: Aspirin	0.8	1.0	1.6	-1.2	-1.3	-0.2
Medication: Gliclazide	2.4	2.7	5.8	0.9	1.3	-2.4
Illnesses of father: None of the above (group 1)	0.7	0.8	1.8	0.8	1.3	0.2
Smoking status: Current	0.2	0.3	0.8	-0.4	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	4.7	-2.2	-1.1	0.0
Whole body water mass	0.4	2.4	7.0	-0.3	0.2	-2.6
Leg predicted mass (right)	0.2	1.3	3.4	-0.7	-0.2	-1.8
Arm fat mass (left)	0.3	1.3	3.6	-0.0	0.5	-1.9
Number of self-reported non-cancer illnesses	0.8	1.5	2.6	-0.9	-1.0	-1.6
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.2	0.2	-0.7
Miserableness	0.3	0.4	0.5	-0.6	-0.7	0.7
Guilty feelings	0.7	1.1	2.3	-1.5	-0.9	-0.2
Wears glasses or contact lenses	0.5	0.6	1.5	-0.2	-1.2	0.4
Ever taken oral contraceptive pill	1.8	2.0	3.4	-1.9	-0.1	-1.6
Hearing aid user	1.8	2.0	3.6	-0.6	-1.9	1.5
Mother’s age at death	2.6	3.2	3.7	-1.7	-1.9	-1.8
Financial situation satisfaction	0.1	0.2	0.3	-0.4	-0.5	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.4	0.8	-0.2
Commuting to job workplace: Public transport	3.6	4.3	12.1	-0.3	-0.7	3.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.1	-0.0	0.8
Medication: Blood pressure	1.2	2.3	6.3	-0.5	-0.4	-2.5
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.2	0.3	0.6	-1.8
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.8	-1.4	-1.9	0.8
High cholesterol (Self-reported)	0.5	0.9	2.7	0.1	-0.2	-1.6
Medication: Bendroflumethiazide	0.9	1.4	2.2	-1.4	-1.5	0.1
Medication: Paracetamol	1.3	2.1	3.5	-1.3	-0.9	-1.9
Medication: Lisinopril	1.2	1.6	2.0	-1.4	-1.2	1.2
Medication: Atorvastatin	0.7	0.8	1.4	-0.9	-1.2	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.5	-0.3	0.1
Alcohol drinker status: Never	0.1	0.2	0.4	-0.6	0.3	-0.1
Ever smoked	2.1	3.6	4.0	-2.0	-2.0	1.7
Basal metabolic rate	0.4	2.3	6.8	-0.2	0.3	-2.6
Leg fat percentage (left)	0.9	3.4	8.0	0.7	1.3	-2.8
Arm fat-free mass (left)	0.6	3.3	9.6	-0.0	0.4	-3.1
Number of operations (self-reported)	1.5	2.2	5.2	-1.2	-2.3	0.1
Average weekly beer plus cider intake	0.1	0.2	0.4	0.1	0.4	-0.7
Irritability	0.8	1.3	2.3	-1.5	-0.7	1.1
Risk taking	0.7	1.0	1.8	1.0	-0.1	-1.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	-0.1	-0.2	-1.0
Fractured/broken bones in last 5 years	0.4	0.5	0.7	0.5	0.7	-0.8
Age started oral contraceptive pill	3.2	4.0	5.3	1.9	1.8	-2.3
Diastolic blood pressure, automated reading	0.2	0.6	1.6	0.3	1.3	-0.2
Ever depressed for a whole week	1.2	1.5	3.0	-1.7	-1.1	0.6
Unable to work because of sickness or disability	0.8	1.0	2.3	1.5	0.4	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.3	-0.2	0.7
Myopia	0.2	0.4	0.5	-0.6	-0.7	-0.3
Vascular/heart problems diagnosed by doctor	1.3	3.6	5.7	2.4	1.2	1.9
Cholesterol lowering medication	0.3	0.4	1.2	0.2	-0.1	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.3	-0.6	0.1	-1.5
Pain experienced in last month	1.2	2.1	5.5	-0.8	-0.2	2.3
Supplements: Calcium	1.2	1.3	3.5	-0.6	-1.9	-0.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.8	0.5	0.3	-1.3
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.3	-1.0	-2.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.5	0.3	1.1	-1.2
Heart disease (siblings)	0.4	0.5	1.4	-0.1	-0.4	-1.2
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.5	-0.4	-0.6
Pack years of smoking	0.7	1.1	1.6	0.2	1.3	-1.3
Impedance of whole body	0.7	3.8	5.3	2.3	2.2	1.1
Leg fat mass (left)	1.0	4.0	10.1	0.5	1.3	-3.2
Arm predicted mass (left)	0.6	3.3	9.4	0.2	0.6	-3.1