Hub : Genes

CTA-228A9.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1180	0.0500	0.0030	0.010	NA	0.009	NA	0.013	8.6e-02	NA	1.0e-01	NA	6.0e-02
2	GTEx	Artery Tibial	0.0602	0.0273	0.0022	0.065	NA	0.032	NA	-0.003	8.4e-06	NA	1.4e-03	NA	6.2e-01
3	GTEx	Brain Cerebellum	0.1740	0.0720	0.0075	0.062	NA	0.106	NA	0.074	6.5e-03	NA	4.8e-04	NA	3.2e-03
4	GTEx	Brain Nucleus accumbens basal ganglia	0.2870	0.1050	0.0049	0.005	NA	0.144	NA	-0.003	2.3e-01	NA	1.1e-04	NA	4.1e-01
5	GTEx	Heart Left Ventricle	0.2041	0.0774	0.0023	0.043	NA	0.130	NA	0.038	2.5e-03	NA	2.0e-07	NA	4.0e-03
6	GTEx	Nerve Tibial	0.0791	0.0371	0.0036	0.070	NA	0.087	NA	0.066	1.1e-05	NA	1.0e-06	NA	1.8e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.7	-0.1	0.0	0.2	-0.8	0.8	1.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.0	0.2	0.1	-0.0	-0.1	0.6
Depressed Affect (Nagel 2018)	1.5	3.1	8.1	-1.2	-1.5	-1.1	-2.8	-1.1	2.1
Depression (Nagel 2018)	0.9	1.3	6.4	-0.3	-0.4	-0.7	-2.5	0.4	-0.8
Intelligence (Savage-Jansen 2018)	1.3	3.9	12.5	2.9	3.5	1.3	-0.7	-0.4	-0.7
Neuroticism (Nagel 2018)	0.8	1.9	5.0	-0.7	-0.8	-1.1	-2.2	-1.0	1.7
Schizophrenia (2018)	0.1	0.2	0.6	-0.1	0.0	-0.1	0.8	-0.7	-0.3
Schizophrenia vs Biploar Disorder	1.2	1.6	2.8	-1.0	-1.3	-1.7	0.4	-1.5	1.2
Worry (Nagel 2018)	1.7	3.6	5.9	-1.4	-1.6	-1.9	-2.3	-2.4	1.3
Alzheimer’s Disease (in mother)	2.5	2.9	7.4	1.6	1.6	2.0	-0.5	0.8	-2.7
Alzheimer’s Disease (in father)	0.7	0.8	2.4	0.6	0.8	0.7	0.6	1.6	0.4
Alzheimer’s Disease (including proxy)	1.2	1.8	3.5	1.0	0.9	1.9	0.6	1.6	-1.6
Crohns Disease (2017)	0.5	1.0	2.8	-0.0	0.8	0.5	-1.0	1.7	-1.2
Irritable Bowel Disease (IBD)	0.3	0.8	2.7	-0.7	-0.5	-1.0	-1.7	-0.2	0.2
Ulcerative Colitis (UC)	0.6	1.1	2.8	-0.7	-0.9	-1.2	-1.7	-0.8	0.7
Major Depression (MDD)	0.5	0.6	1.2	0.0	-1.1	-1.0	-1.0	-0.8	-0.1
Reaction Time	3.2	6.1	8.7	2.8	2.9	2.8	2.6	0.9	-2.1
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.0	1.3	2.0	0.3	1.3	-0.7	-0.0
Breast Cancer	4.8	11.5	18.1	-3.0	-3.6	-3.8	-3.8	-4.3	0.6
Ovarian Cancer	0.6	0.8	2.5	0.3	0.2	-0.8	-1.6	-0.9	-0.8
Prostate Cancer	0.8	1.1	3.1	0.7	0.7	1.1	-0.6	1.8	-1.1
Age at First Birth	2.7	3.9	9.0	1.7	1.8	1.8	-2.1	0.8	-3.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.0	-1.1	-0.9	-0.6	-0.6	-1.4	-0.2
Coronary Artery Disease (CAD)	3.7	4.4	8.1	-2.3	-2.2	-2.8	0.6	-2.9	0.4
Crohns Disease (2012)	0.2	0.2	0.7	0.1	0.7	-0.1	0.6	0.8	-0.1
Mean Putamen Volume	0.7	0.8	2.1	-0.4	0.3	1.5	0.2	0.7	-1.3
Fasting Glucose	0.4	0.5	1.4	0.4	0.3	1.1	0.1	1.2	-0.6
HbA1C	2.5	2.8	11.7	0.8	0.9	0.9	-0.1	1.6	-3.4
HDL Cholesterol	0.3	0.5	2.1	0.2	0.4	-0.2	-0.5	-0.5	-1.4
LDL Cholesterol	2.2	3.4	4.5	2.1	2.1	2.1	0.8	2.0	-1.6
Lupus	1.5	2.2	5.8	0.5	0.4	2.4	1.0	2.4	-0.5
Neuroticism (2016)	0.9	1.3	2.9	1.0	0.9	0.7	-1.7	0.8	-1.5
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.1	-0.1	-0.1	-1.1	-0.1	-1.0
Rheumatoid Arthritis	1.4	1.9	3.1	-1.6	-1.3	-1.6	-1.8	-1.3	0.5
Schizophrenia (2014)	0.3	0.6	1.5	-0.2	-0.3	-0.7	1.2	-1.0	0.7
Triglycerides	0.7	1.2	2.0	0.8	0.7	1.1	-1.0	1.2	1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	0.4	0.8	0.6	0.1	1.1	-0.2
Ulcerative Colitis	1.6	2.4	6.6	-1.1	-1.3	-1.7	-0.6	-2.6	1.3
Blood Eosinophil Count	0.7	5.3	12.5	2.8	2.2	3.5	1.2	2.3	0.1
Blood Platelet Count	0.6	6.4	11.4	-3.4	-3.0	-2.7	-2.0	-2.2	1.4
Blood Red Count	0.4	4.2	19.5	0.9	-0.9	0.1	1.4	1.4	4.4
Blood White Count	0.1	0.4	1.3	-0.2	-0.9	-0.3	0.0	-0.4	1.2
Heel T-Score	2.0	16.1	35.5	-3.0	-4.2	-2.3	5.4	0.8	6.0
BMI	1.3	7.3	19.3	-3.5	-4.4	-1.8	-1.6	-2.0	1.5
Height	0.4	6.9	12.9	-0.2	1.3	-2.5	-3.1	-3.6	-3.3
Waist Hip Ratio (WHR)	0.4	1.8	3.0	-0.5	-1.5	-1.4	-1.7	-1.2	1.4
Systolic Blood Pressure	0.8	3.8	9.6	-1.3	-2.3	-3.1	0.1	-1.8	1.8
Smoking Status	3.1	7.3	13.5	2.2	3.0	3.7	1.2	3.3	-2.1
Allergy or Eczema	0.2	0.5	2.4	0.5	0.2	0.1	-0.2	-0.6	-1.6
Cardiovascular Disease	0.2	0.7	1.7	-0.1	-0.6	-1.3	-1.0	-0.2	1.1
Hypothyroidism (self reported)	0.3	0.7	2.1	-0.1	-1.2	-0.0	-0.7	-1.4	-0.5
Respiratory disease	0.9	1.9	5.3	2.3	1.7	1.0	0.8	0.7	-1.1
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.9	1.6	1.6	1.6	-2.0	0.8	-0.0
Lung FEV1/FVC ratio	0.2	1.1	3.1	-0.2	-1.8	-1.2	-0.5	-0.9	-0.9
Lung FVC	0.5	2.6	4.9	0.8	2.1	2.2	-0.0	1.3	-1.9
Neuroticism	0.7	1.8	7.1	-0.7	-0.4	-0.8	-1.4	-0.6	2.7
Chronotype (morning person)	0.2	0.3	1.1	0.1	-0.1	-0.7	0.7	-1.0	-0.1
Hair Pigment	0.1	2.5	8.6	1.3	1.3	1.5	-0.3	0.6	-2.9
Tanning	0.4	4.6	22.2	0.5	1.4	0.6	-1.4	-1.0	-4.7
Hand grip strength (left)	0.9	2.4	8.2	-0.2	-1.0	-1.3	2.9	-1.2	1.5
Number of treatments/medications taken	0.2	0.3	1.4	0.2	-0.2	0.4	-0.3	0.2	-1.2
Average weekly spirits intake	0.4	0.5	2.4	0.0	0.5	0.3	-0.4	-0.1	-1.5
Sensitivity / hurt feelings	0.7	1.2	3.7	-0.8	-0.4	-1.3	0.1	-1.0	1.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.8	0.8	0.8	0.5	-0.9	0.8	-0.7
Hearing difficulty/problems: Yes	5.0	7.6	15.0	-2.1	-2.4	-3.9	-0.5	-2.6	3.7
Relative age of first facial hair	0.3	0.7	1.8	0.1	0.4	-0.0	-1.2	-0.7	-1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	1.4	1.1	0.8	0.1	-0.0	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-0.8	-1.0	-0.4	0.2	-0.2	-0.6
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.8	-0.2	-1.2	-1.0	-1.0	0.4
Systolic blood pressure, automated reading	0.3	1.0	2.5	-0.8	-1.5	-1.6	-0.1	-0.6	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.2	0.3	-0.4	-0.9	-0.7	0.5
Angina	0.1	0.2	0.8	-0.3	-0.1	-0.0	-0.9	-0.3	-0.1
Medication for hormone replacement therapy	0.9	1.0	3.9	-0.3	0.0	-1.3	-0.5	-2.0	0.2
Vitamin and mineral supplements	0.2	0.3	1.4	0.4	0.4	0.1	0.3	1.2	-0.2
Supplements: Zinc	1.0	1.1	2.7	-0.7	-0.5	-0.4	-1.5	-0.9	1.6
Medication: Co-codamol	0.7	0.9	2.0	-1.2	-1.1	-0.7	-0.2	-1.4	-0.2
Medication: Metformin	1.1	1.6	6.1	0.4	0.4	0.8	-2.5	0.5	1.5
Diabetes (father)	0.6	0.7	1.5	-0.5	0.5	-1.1	-0.3	-0.9	1.2
Diabetes (mother)	0.8	1.1	4.4	-0.4	-0.3	-0.4	-0.0	1.2	2.1
Severe depression (siblings)	0.3	0.4	1.3	-0.4	0.5	-0.0	-1.1	-0.7	-0.2
Pack years adult smoking proportion	3.3	5.0	6.0	-2.4	-2.4	-2.1	-2.5	-1.5	2.4
Impedance of leg (right)	0.4	2.2	8.9	1.1	1.3	-0.5	-0.4	0.9	-3.0
Leg fat-free mass (left)	1.6	8.2	11.9	-3.5	-3.3	-2.3	-2.9	-3.1	1.7
Trunk fat percentage	2.6	10.2	17.3	-4.2	-4.1	-2.1	-4.0	-1.6	-2.1
Hand grip strength (right)	1.0	2.8	6.2	-0.7	-1.3	-2.0	2.5	-0.9	2.0
Townsend deprivation index at recruitment	0.6	0.8	2.3	-0.9	0.0	0.3	-1.3	1.5	0.2
Current tobacco smoking	0.3	0.5	1.3	0.5	1.1	0.5	1.0	0.3	0.4
Average weekly fortified wine intake	0.8	0.9	3.0	1.2	0.5	0.8	-0.0	-0.6	-1.7
Maternal smoking around birth	2.0	3.0	5.9	0.9	2.0	1.5	-1.5	2.4	-1.5
Fed-up feelings	1.7	3.0	13.3	-1.4	-1.3	-1.0	-0.2	-0.5	3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.2	-0.7	-1.0	-0.7	-2.1	0.1	0.4
Relative age voice broke	0.6	0.8	1.7	-0.7	-0.7	-1.1	-0.4	-1.3	-1.0
Taking other prescription medications	0.5	0.8	4.1	0.4	0.4	0.3	-2.0	-0.6	-0.1
Age when periods started (menarche)	2.6	6.3	12.1	2.3	2.4	2.5	3.5	2.4	-1.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.2	0.7	-0.1	0.5	-0.7	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.1	-0.9	-1.8	-1.3	2.7	0.5	2.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.1	0.9	0.3	1.0	2.0	0.6	-0.0
Qualifications: CSEs or equivalent	0.6	0.7	3.4	-0.6	-0.6	-0.1	-1.8	-0.1	0.5
Serious illness, injury or assault to yourself	0.5	0.6	2.3	0.1	-0.0	-0.3	-1.5	-0.2	1.1
High blood pressure	0.5	1.4	5.9	-0.6	-0.6	-1.2	-2.4	-0.2	-0.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.9	-0.4	-0.8	-0.9	-0.2	-1.7	-0.2
Multivitamins +/- minerals	0.3	0.4	1.3	0.2	0.4	0.1	-1.0	-1.1	-0.0
Stomach or abdominal pain in last month	0.3	0.4	0.9	-0.0	-0.2	0.6	0.7	1.0	-0.8
Supplements: Glucosamine	0.9	1.2	2.7	-1.0	-1.3	-0.8	-0.7	-1.6	-0.8
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.4	-1.6	-1.4	-1.9	-2.1	-1.5	0.2
Medication: Atenolol	0.3	0.4	1.2	0.3	0.1	0.3	-0.9	0.6	-1.1
Medication: Levothyroxine sodium	0.2	0.4	1.2	0.7	0.0	1.1	-0.4	-0.2	-0.8
Sitting height	0.4	2.9	7.5	0.6	2.3	-0.4	-2.7	-1.2	-1.7
Chronic bronchitis/emphysema (father)	1.0	1.1	2.0	1.1	1.3	0.9	-0.3	1.4	1.0
High blood pressure (mother)	0.4	0.6	2.0	0.7	0.4	-0.3	-1.4	0.5	0.9
Body mass index (BMI)	1.1	4.9	12.3	-3.2	-3.5	-1.2	-1.6	-1.3	1.0
Impedance of leg (left)	0.6	3.1	12.6	1.4	1.5	-0.1	-0.1	1.4	-3.5
Leg predicted mass (left)	1.5	8.0	11.6	-3.4	-3.2	-2.3	-2.9	-3.1	1.7
Trunk fat mass	2.5	10.6	18.9	-4.3	-4.2	-2.5	-3.9	-2.2	-1.2
Waist circumference	1.6	5.7	12.4	-3.1	-3.5	-1.6	-2.8	-1.2	0.6
Number of incorrect matches in round	3.0	4.9	8.5	-2.2	-2.9	-2.9	-1.0	-2.2	1.4
Past tobacco smoking	4.7	8.6	15.7	-2.3	-2.9	-4.0	-1.7	-3.5	2.6
Alcohol usually taken with meals	0.6	0.9	1.6	-0.4	-0.9	-0.9	-1.1	-1.1	-1.2
Nervous feelings	0.7	1.2	3.8	0.1	-0.5	-0.7	-2.0	-1.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	5.4	0.4	-0.1	-0.2	-2.3	0.2	0.4
Hearing difficulty/problems with background noise	4.2	6.8	12.8	-2.6	-2.9	-3.1	-0.5	-1.7	3.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	-0.2	0.3	-0.3	-0.1	0.7	0.7
Had menopause	1.2	1.5	2.6	1.0	0.9	1.6	-0.9	1.1	-1.6
Had other major operations	1.2	1.4	4.2	0.9	0.2	1.8	-0.1	2.0	-0.4
Forced vital capacity (FVC)	0.3	1.2	2.4	0.7	1.5	0.6	-1.4	-0.7	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	7.3	-0.9	-1.5	-1.0	2.2	1.0	2.7
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	3.4	-1.7	-1.8	-0.8	-1.2	-1.6	1.0
Qualifications: None of the above	0.7	1.6	3.1	-1.8	-1.3	-1.5	-1.3	-0.7	0.8
Financial difficulties in last 2 years	1.0	1.4	7.2	0.1	0.2	0.1	-2.7	0.2	-1.1
Mouth/teeth dental problems	1.2	1.9	6.4	-1.0	-1.4	-1.4	-0.5	-2.5	0.1
Heart attack	0.5	0.6	1.5	0.5	0.9	0.3	-1.2	0.2	0.9
Allergy	0.7	1.5	4.7	0.9	1.4	1.2	-0.2	2.2	0.1
Pain all over the body in last month	0.1	0.1	0.6	-0.2	0.0	0.2	-0.8	0.1	-0.1
Diabetes (self-reported)	1.8	2.9	4.5	2.0	2.1	2.1	-1.4	1.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.2	0.2	0.3	0.2	0.7	-0.7
Medication: Ramipril	0.8	1.0	2.9	-0.7	-0.7	-1.4	0.0	-1.7	0.6
Medication: Simvastatin	0.3	0.4	1.4	-0.2	-0.4	-0.6	-0.3	1.2	-0.3
Fluid intelligence score	0.8	1.7	4.6	1.6	2.2	-0.0	1.2	-0.7	-1.0
Illnesses of siblings	0.2	0.2	0.5	0.5	0.5	0.7	0.1	0.7	-0.1
Neuroticism score	1.7	3.5	8.2	-1.7	-1.6	-1.9	-1.6	-1.1	2.9
Weight	1.5	7.5	12.4	-3.5	-3.4	-2.2	-3.2	-2.4	0.1
Impedance of arm (right)	1.0	4.4	21.8	-0.4	0.0	-0.2	-2.1	-0.3	-4.7
Arm fat percentage (right)	1.9	7.4	16.7	-3.9	-4.1	-1.5	-2.7	-1.6	-0.7
Trunk fat-free mass	0.7	4.2	6.8	-1.8	-1.7	-1.9	-1.5	-2.5	2.6
Hip circumference	1.3	5.5	9.4	-3.1	-3.0	-1.6	-3.0	-1.5	-0.8
Time employed in main current job	0.1	0.1	0.2	0.4	-0.2	0.5	-0.3	0.4	-0.2
Alcohol intake versus 10 years previously	0.5	0.8	2.0	-0.6	-0.8	-0.3	-1.4	-0.3	1.2
Father’s age at death	0.1	0.1	0.5	0.4	0.7	0.1	-0.2	0.1	-0.1
Worrier / anxious feelings	1.7	3.2	6.5	-1.3	-1.2	-2.6	-1.2	-2.4	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.0	-0.3	-1.1	1.0	0.1	1.4	0.9
Falls in the last year	1.1	1.4	2.8	-1.7	-1.2	-1.2	-1.0	-1.1	-0.7
Hair/balding pattern: Pattern 3	0.5	0.8	3.4	0.7	0.5	0.7	-0.3	0.1	-1.8
Number of live births	0.2	0.2	0.6	-0.5	-0.4	0.7	0.1	0.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.0	0.4	0.7	0.1	-1.0	-0.9	-1.4
Pulse rate	1.3	2.1	6.7	-1.1	-1.4	-1.2	2.6	0.2	1.2
Happiness	1.5	1.8	6.0	0.7	-0.2	-0.1	-2.4	-0.7	1.9
Noisy workplace	2.7	3.3	12.7	-1.7	-1.5	-1.4	-3.6	-0.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.4	3.4	1.8	1.6	0.9	-0.2	-0.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	2.8	1.4	1.5	1.0	-0.8	1.4	-1.7
Mouth/teeth dental problems: Dentures	1.4	2.3	3.9	1.4	1.7	1.8	1.2	2.0	-1.0
Asthma	0.4	0.9	3.9	0.7	0.5	0.6	2.0	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.9	1.0	0.4	-0.2	1.2	0.0	-1.4
Medication: Cholesterol lowering	0.2	0.3	0.9	0.1	0.2	-0.3	-1.0	0.3	-0.8
Depression (self-reported)	0.2	0.3	1.0	-0.4	-0.3	0.5	-0.0	0.1	1.0
Medication: Lansoprazole	0.5	0.5	2.6	0.1	-0.0	1.6	-0.7	-0.0	0.2
Prospective memory result	0.9	1.1	3.5	-0.9	-0.8	0.5	1.0	1.9	-0.7
Lung cancer (father)	1.0	1.1	2.1	1.0	1.5	1.1	-0.1	0.9	-1.2
Illnesses of mother	0.3	0.3	0.9	-0.5	0.1	-0.5	0.2	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.0	0.1	0.4	-0.3	-1.0	-0.7	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	2.2	-0.4	0.2	-0.2	-1.5	0.0	-0.4
Impedance of arm (left)	1.0	4.8	21.1	-0.7	-0.0	-0.5	-2.7	-0.3	-4.6
Arm fat mass (right)	2.0	8.1	16.5	-4.0	-4.1	-2.0	-2.7	-2.1	0.2
Trunk predicted mass	0.7	4.3	7.5	-1.8	-1.7	-1.9	-1.3	-2.5	2.7
Standing height	0.5	5.0	12.7	-1.0	-0.0	-2.4	-3.6	-2.6	-1.9
Length of working week for main job	2.5	2.7	5.2	0.9	1.8	1.2	-2.3	1.1	-2.1
Exposure to tobacco smoke at home	0.1	0.2	0.3	0.4	0.4	-0.1	-0.0	0.5	0.5
Breastfed as a baby	1.5	1.8	3.4	1.9	1.0	0.9	1.4	0.9	-1.7
Tense / ‘highly strung’	1.1	1.9	3.2	-1.2	-1.8	-1.5	-1.3	-0.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.8	-0.9	-0.0	-0.7	0.8	1.1
Hair/balding pattern: Pattern 4	0.8	2.0	5.7	0.5	0.2	1.3	-1.9	0.8	-2.4
Birth weight of first child	1.8	3.3	5.1	-2.1	-1.8	-2.1	-1.3	-2.3	0.7
Peak expiratory flow (PEF)	0.6	1.3	2.2	-0.6	-0.9	-1.1	1.0	-1.5	-1.5
Pulse wave reflection index	1.0	1.2	2.7	0.6	1.2	1.2	-1.6	0.7	-0.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.6	0.0	-0.9	-0.1	-0.6	-0.8	2.1
Loud music exposure frequency	0.4	0.4	1.0	-0.7	-1.0	-0.1	0.0	0.6	0.9
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.6	1.9	1.9	1.6	0.1	-0.8	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.4	0.9	1.0	0.6	0.1	1.5	0.0
Blood clot in the leg (DVT)	1.8	2.3	4.4	-2.1	-2.0	-1.3	-0.8	-1.6	-0.5
Medication: Paracetamol	0.5	0.9	3.2	0.4	0.1	0.7	1.0	1.8	0.6
Headache pain in last month	0.2	0.4	0.6	-0.6	-0.8	-0.5	0.7	-0.3	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.5	-0.7	-0.5	0.1	0.6	-0.1	1.2
Glaucoma (self-reported)	0.4	0.5	1.3	-0.5	-1.1	0.1	0.5	0.9	-0.3
Gout (self-reported)	0.8	1.1	2.5	1.1	1.2	1.6	0.9	0.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.4	-0.4	0.8	0.0	-0.5	-1.0
Medication: Amlodipine	0.1	0.1	0.4	0.6	0.3	0.2	0.3	0.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-0.1	-0.4	-0.5	0.2	-1.1	0.7
Birth weight	0.1	0.3	1.3	-0.1	0.3	0.1	1.1	-0.6	-0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.2	0.1	0.8	-0.0	-1.5	-0.1	-1.4
High blood pressure (siblings)	0.2	0.3	0.9	-0.5	-0.8	-0.1	0.3	0.2	1.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.6	0.4	1.2	-0.1	-1.3	-0.7	-0.4
Body fat percentage	2.3	9.1	16.9	-4.0	-4.1	-1.9	-3.6	-1.3	-1.7
Leg fat percentage (right)	1.5	5.6	13.1	-3.4	-3.6	-1.6	-2.3	-0.8	-0.8
Arm fat-free mass (right)	0.8	4.3	6.5	-2.2	-2.1	-2.0	-1.5	-1.9	2.6
Exposure to tobacco smoke outside home	0.9	1.2	4.1	-1.1	-0.5	0.6	-2.0	1.0	-0.4
Comparative body size at age 10	0.1	0.3	1.1	0.3	1.0	0.3	-0.8	-0.1	0.2
Number of full brothers	1.3	1.6	3.0	1.1	1.7	1.6	-0.4	1.6	0.4
Worry too long after embarrassment	0.1	0.2	0.8	-0.2	0.2	-0.4	-0.0	-0.3	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	6.9	-1.2	-1.4	-0.3	-2.6	0.2	0.7
Wheeze or whistling in the chest in last year	0.8	1.4	3.3	0.9	0.7	1.8	0.6	1.7	-0.4
Number of children fathered	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.4	0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.5	-0.1	-0.2	0.3	1.2	0.4	-0.2
Age at first live birth	0.4	0.7	2.0	0.3	-0.0	0.1	-1.4	-0.9	-1.2
Pulse wave peak to peak time	0.2	0.3	1.1	0.5	-0.1	0.2	1.1	-0.2	0.2
Health satisfaction	2.6	3.3	11.2	-0.6	-1.0	-1.7	-3.3	-2.1	0.3
Shortness of breath walking on level ground	1.5	1.8	5.2	-1.3	-1.1	-0.8	-2.3	-0.6	-1.4
Qualifications: College or University degree	2.1	6.7	11.2	3.3	3.0	2.0	3.1	2.0	-1.6
Eye problems/disorders: None of the above	0.6	0.7	3.4	-0.5	-0.5	-0.6	-0.0	-0.1	1.9
Mouth/teeth dental problems: Loose teeth	2.5	3.0	6.2	1.9	2.5	1.8	-0.0	2.0	1.1
Emphysema/chronic bronchitis	1.0	1.1	3.2	1.8	1.5	0.7	-0.7	0.1	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	3.3	0.1	0.8	-0.1	-1.8	-1.0	-0.1
Neck or shoulder pain in last month	1.6	2.3	4.3	1.6	1.3	1.8	-0.4	2.1	-1.3
Medication: Blood pressure	0.2	0.3	0.9	0.5	0.3	-0.3	-1.0	-0.2	-0.7
Angina (self-reported)	0.3	0.4	1.9	-0.5	-0.2	-0.2	-1.4	-0.5	-0.0
Migraine (self-reported)	0.5	0.7	1.2	0.6	1.1	1.1	0.4	1.0	-0.4
Medication: Ibuprofen	1.4	1.6	3.4	1.7	0.8	0.6	1.4	0.9	-1.8
Medication: Allopurinol	0.1	0.2	0.5	-0.3	-0.2	0.2	0.2	-0.5	0.7
Medication: Omeprazole	0.3	0.3	1.2	-0.1	-0.0	1.1	-0.2	0.2	-0.8
Medication: Seretide 50 evohaler	1.0	1.2	2.6	-0.5	-0.4	-1.1	1.0	-1.4	1.6
Mean time to correctly identify matches	4.4	8.4	12.2	3.1	3.4	3.5	2.5	2.1	-2.6
Heart disease (mother)	0.3	0.4	0.6	0.8	0.8	0.7	0.6	0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.3	1.1	0.7	1.2	0.0	0.5	-1.5
Whole body fat mass	2.4	10.1	18.4	-4.3	-4.3	-2.4	-3.6	-2.1	-0.6
Leg fat mass (right)	2.2	8.3	17.4	-4.1	-4.2	-2.4	-2.6	-1.9	-0.0
Arm predicted mass (right)	0.9	4.8	5.6	-2.3	-2.1	-2.3	-1.7	-2.3	2.4
Pulse rate, automated reading	0.4	1.2	4.6	0.4	-0.4	-0.2	2.1	0.1	1.5
Alcohol intake frequency.	0.6	1.3	6.7	0.0	-0.3	-0.0	-2.6	-0.5	0.9
Comparative height size at age 10	1.0	5.6	13.1	-1.8	-1.6	-2.8	-3.6	-2.6	-0.6
Number of full sisters	1.1	1.4	4.5	-1.1	-1.1	-0.9	-0.6	-2.1	-0.1
Suffer from ‘nerves’	1.5	2.3	4.7	-1.2	-1.3	-2.2	-0.9	-1.7	1.5
Overall health rating	1.3	2.7	13.6	-1.0	-1.1	-0.3	-3.7	-0.7	0.1
Chest pain or discomfort	2.4	3.5	10.4	1.4	1.2	2.0	-1.6	3.2	0.9
Had major operations	0.0	0.1	0.1	-0.0	0.2	0.2	0.1	-0.2	0.4
Age at last live birth	0.6	0.8	2.5	-0.2	-0.7	-0.4	-1.6	-1.3	0.0
Family relationship satisfaction	0.4	0.5	2.0	0.4	0.2	0.7	-1.4	-0.2	-0.0
Leg pain on walking	0.9	1.1	3.1	-0.6	-0.7	0.0	-1.8	-0.2	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.4	-0.3	-0.3	-0.6	1.1	1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.8	0.5	0.0	-0.4	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	5.8	-2.0	-2.4	-1.2	1.0	-1.3	0.7
Medication: Aspirin	0.6	0.8	1.4	-1.0	-1.2	-1.0	-0.8	-0.2	0.8
Supplements: Vitamin C	1.6	1.9	4.2	-1.4	-1.7	-1.2	-0.0	-2.1	0.7
Knee pain experienced in last month	1.0	1.5	4.9	-0.6	-0.9	-0.3	-1.7	0.1	-2.2
Hypertension (Self-reported)	0.3	0.9	4.1	-0.1	-0.1	-0.7	-2.0	0.4	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.4	-1.6	-1.1	-0.7	0.0	-0.4	-0.9
Illnesses of father: Heart disease	0.7	0.9	4.3	-0.4	-0.3	0.3	1.0	-0.0	-2.1
Illnesses of siblings: Diabetes	0.2	0.2	0.8	0.1	0.1	-0.1	0.6	-0.3	0.9
Smoking status: Previous	4.0	6.0	11.0	2.0	2.2	3.3	1.3	2.7	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	0.5	0.6	-0.5	-0.7	-0.4	0.2
Whole body fat-free mass	0.9	5.4	7.5	-2.4	-2.3	-2.1	-1.9	-2.7	2.4
Leg fat-free mass (right)	1.2	6.6	9.9	-3.1	-2.9	-2.1	-2.6	-2.8	1.6
Arm fat percentage (left)	2.2	8.7	18.6	-4.2	-4.3	-1.8	-3.2	-1.7	-0.5
Average weekly red wine intake	0.6	0.9	4.7	0.0	-0.6	0.0	2.2	-0.5	-0.3
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.8	-0.9	-0.6	-1.3	-1.0	-2.0	1.6
Mood swings	2.1	3.7	7.8	-1.5	-1.8	-1.8	-2.8	-1.2	2.1
Loneliness, isolation	0.6	0.9	1.4	-0.8	-1.2	-1.0	-1.0	0.0	1.1
Long-standing illness, disability or infirmity	1.9	2.9	6.7	2.6	1.9	2.2	-0.9	1.0	-0.6
Ever had bowel cancer screening	1.0	1.2	3.4	0.9	1.1	0.7	0.8	1.8	-0.7
Diabetes diagnosed by doctor	1.0	1.7	3.1	1.2	1.5	1.3	-1.8	0.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.6	-1.2	-1.1	-0.5	0.3	-0.7	-0.2
Friendships satisfaction	1.1	1.4	5.7	1.1	0.5	-0.1	-2.4	-1.1	0.3
Qualifications: nursing, teaching	0.6	0.9	2.9	0.9	0.3	1.0	0.7	0.1	-1.7
Commuting to job workplace: Walk	0.6	0.6	2.5	-0.3	-0.4	-0.0	1.6	0.9	0.3
Eye problems/disorders: Cataract	0.6	0.7	2.4	-0.2	-0.3	-0.9	-0.2	-1.6	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	-0.7	-1.1	-0.3	0.5	0.9	0.7
Medication for cholesterol	1.9	2.9	4.6	1.7	1.5	2.1	1.2	1.9	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.2	-0.5	0.1	0.9	2.1	1.4	-0.7
Back pain experienced in last month	0.3	0.4	1.8	-0.3	0.0	0.7	-0.3	1.4	-0.2
Mineral and other dietary supplements	0.3	0.4	1.1	-0.2	-0.2	-0.4	-0.8	1.1	-0.8
Breast cancer (self-reported)	1.6	1.9	4.4	0.8	0.9	2.1	-0.6	1.9	-1.4
Asthma (self-reported)	0.4	0.9	3.9	0.7	0.6	0.5	2.0	0.2	0.3
Osteoporosis (self-reported)	1.5	1.8	3.4	1.4	1.8	1.5	-0.4	0.9	-1.5
Osteoarthritis (self-reported)	1.3	1.7	5.2	0.8	0.4	1.2	0.5	2.3	-1.5
Medication: Aspirin	0.6	0.8	1.1	-0.9	-1.0	-1.1	-1.0	-0.3	1.0
Medication: Gliclazide	2.0	2.2	2.8	1.7	1.6	1.6	-1.3	1.1	-1.7
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	-0.2	-0.6	-0.6	-1.2	-0.5	-0.0
Smoking status: Current	0.4	0.6	1.5	0.3	0.8	0.5	1.2	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	-0.4	-0.1	-0.5	-0.9	0.1	-1.2
Whole body water mass	1.0	5.6	7.5	-2.4	-2.3	-2.1	-2.0	-2.7	2.5
Leg predicted mass (right)	1.2	6.3	9.2	-3.0	-2.8	-2.0	-2.6	-2.7	1.5
Arm fat mass (left)	1.8	7.6	15.0	-3.8	-3.9	-1.8	-2.9	-2.0	0.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.4	0.2	0.0	0.1	0.2	0.1	-0.6
Average weekly champagne plus white wine intake	0.4	0.5	1.7	-0.3	-0.5	-0.3	0.4	-0.9	-1.3
Miserableness	1.7	2.9	9.6	-1.5	-1.8	-1.3	-0.3	-0.4	3.1
Guilty feelings	0.6	0.8	3.6	-0.4	0.0	-0.5	-1.0	0.1	1.9
Wears glasses or contact lenses	0.6	0.7	1.9	-0.8	-0.9	-1.4	0.8	-0.5	-0.0
Ever taken oral contraceptive pill	1.4	1.5	3.3	1.8	1.5	1.4	-1.2	0.4	-0.4
Hearing aid user	2.8	3.2	7.7	-1.4	-1.1	-2.8	-0.2	-2.2	1.8
Mother’s age at death	0.5	0.7	1.5	0.7	1.2	0.3	0.6	-0.2	-1.2
Financial situation satisfaction	0.6	0.7	2.2	0.8	0.5	1.5	-1.1	0.1	-0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	-0.5	-0.4	-0.9	-1.2	-0.2	1.3
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.2	0.5	0.6	0.6	0.3	0.6
Eye problems/disorders: Glaucoma	0.8	1.0	2.2	-0.7	-1.5	-0.1	0.8	1.4	-0.6
Medication: Blood pressure	0.6	1.2	2.1	-1.4	-1.0	-1.3	-1.4	-0.7	0.3
Pain type(s) experienced in last month: Hip pain	1.1	1.3	3.1	1.7	1.4	1.1	0.6	1.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.9	0.0	-0.1	0.3	1.7	-1.1	1.2
High cholesterol (Self-reported)	0.3	0.5	0.9	-1.0	-0.7	-0.5	0.4	0.7	0.8
Medication: Bendroflumethiazide	0.5	0.7	2.3	-0.1	0.1	-0.6	-1.5	-0.4	-1.2
Medication: Paracetamol	0.3	0.5	2.3	0.1	-0.2	0.9	0.1	1.5	-0.2
Medication: Lisinopril	1.5	2.0	4.9	-1.8	-1.1	-1.5	-2.2	-0.1	0.6
Medication: Atorvastatin	1.8	2.2	7.3	-1.1	-0.5	-0.7	-2.7	-1.6	1.3
Illnesses of father: High blood pressure	0.3	0.3	1.5	-0.1	-0.1	0.5	-0.2	1.2	0.2
Alcohol drinker status: Never	0.3	0.4	1.3	-0.2	-0.7	0.1	-0.6	-0.3	-1.1
Ever smoked	2.0	3.5	8.3	1.6	1.9	2.9	1.1	1.8	-1.4
Basal metabolic rate	1.1	6.3	8.1	-2.9	-2.7	-2.2	-2.4	-2.8	1.9
Leg fat percentage (left)	1.4	5.0	12.1	-3.2	-3.5	-1.2	-2.1	-0.5	-1.1
Arm fat-free mass (left)	0.6	3.2	4.2	-1.9	-1.9	-1.9	-1.1	-1.9	2.0
Number of operations (self-reported)	0.1	0.2	0.4	0.2	0.2	0.6	-0.6	0.6	-0.0
Average weekly beer plus cider intake	2.6	3.8	8.6	1.1	1.4	2.5	2.1	2.9	0.2
Irritability	1.1	1.8	3.5	-1.4	-1.8	-0.2	-1.4	0.1	1.9
Risk taking	0.4	0.6	2.4	-0.1	0.3	0.3	1.5	0.9	0.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.8	-0.7	-0.8	-2.2	-1.0	-1.4	0.9
Fractured/broken bones in last 5 years	3.0	3.8	9.9	-1.5	-1.0	-2.1	-3.1	-2.4	0.1
Age started oral contraceptive pill	1.1	1.4	3.3	1.2	0.8	1.8	0.7	1.2	-0.9
Diastolic blood pressure, automated reading	0.2	0.5	1.5	-0.0	-0.6	-1.0	1.2	0.4	-0.2
Ever depressed for a whole week	0.3	0.4	0.7	-0.5	-0.8	-0.4	-0.4	-0.8	-0.5
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.4	-0.1	0.6	-0.5	-0.3	0.3
Commuting to job workplace: Cycle	0.5	0.6	2.2	-0.1	-0.1	-0.3	-1.5	-1.1	-0.2
Myopia	0.3	0.4	1.1	-0.1	-0.1	-1.1	0.6	-1.1	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.7	8.4	0.4	0.5	1.1	2.9	0.1	0.1
Cholesterol lowering medication	0.8	1.2	4.4	-1.2	-1.0	-0.3	-0.5	0.3	2.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.9	-0.3	-0.2	1.0	-0.1	0.2	-0.4
Pain experienced in last month	0.2	0.3	1.1	-0.1	0.1	-0.7	1.0	-0.6	0.3
Supplements: Calcium	0.5	0.5	1.7	0.5	0.6	1.3	0.8	-0.0	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.0	-0.6	-0.3	0.2	0.6	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.2	0.6	1.0	0.5	-1.1	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	4.9	-2.2	-2.1	-1.6	-1.0	-2.1	-0.3
Heart disease (siblings)	0.7	0.9	1.7	-1.3	-1.0	-1.3	-0.2	-0.7	-0.8
Alcohol drinker status: Previous	1.1	1.3	3.3	-0.2	-0.2	-0.8	-1.8	-1.5	1.2
Pack years of smoking	3.1	4.6	5.6	-2.4	-2.4	-2.1	-2.3	-1.5	2.2
Impedance of whole body	0.9	4.6	23.2	0.4	0.9	-0.2	-1.8	0.6	-4.8
Leg fat mass (left)	2.0	7.9	16.9	-4.0	-4.1	-2.2	-2.5	-1.8	-0.2
Arm predicted mass (left)	0.6	2.9	4.0	-1.7	-1.8	-1.6	-1.2	-1.9	2.0