Hub : Genes

CTB-33G10.6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.214	0.095	0.0100	0.017	NA	-0.005	NA	-0.012	0.130	NA	0.4500	NA	0.8000
2	GTEx	Spleen	0.337	0.120	0.0023	-0.010	NA	0.024	NA	0.035	0.740	NA	0.0810	NA	0.0440
3	GTEx	Whole Blood	0.070	0.030	0.0065	0.010	NA	0.028	NA	0.024	0.036	NA	0.0012	NA	0.0024

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.8	-1.3	1.0	-0.0
Bipolar Disorder or Schizophrenia	1.1	2.8	5.9	-2.4	0.5	1.5
Depressed Affect (Nagel 2018)	1.3	2.7	4.1	1.0	2.0	-1.7
Depression (Nagel 2018)	0.2	0.3	0.7	-0.4	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.8	1.9	-1.3	-1.3
Neuroticism (Nagel 2018)	1.6	3.8	9.1	3.0	-0.6	-1.4
Schizophrenia (2018)	1.3	2.6	4.2	-2.0	-0.1	1.9
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.3	-0.3	0.4
Worry (Nagel 2018)	1.8	3.7	7.4	2.7	-1.1	-1.5
Alzheimer’s Disease (in mother)	3.9	4.6	9.7	-0.4	2.0	3.1
Alzheimer’s Disease (in father)	1.1	1.2	3.0	0.0	0.8	1.7
Alzheimer’s Disease (including proxy)	3.0	4.4	11.7	-0.1	1.2	3.4
Crohns Disease (2017)	0.6	1.2	1.5	1.2	0.9	1.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.9	0.4	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.1	0.3	-0.6
Major Depression (MDD)	0.1	0.1	0.3	0.0	0.6	0.0
Reaction Time	0.8	1.6	3.0	0.7	-1.1	-1.7
Verbal and Numeric Reasoning (VNR)	1.6	3.9	5.2	2.3	-2.0	-1.7
Breast Cancer	1.1	2.6	3.5	1.5	-1.4	-1.9
Ovarian Cancer	0.5	0.7	1.5	-1.2	-0.4	-0.7
Prostate Cancer	0.1	0.1	0.2	0.3	-0.5	0.1
Age at First Birth	2.3	3.3	5.3	2.3	-2.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.7	2.4	-0.7	-1.5	-1.5
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.8	1.9	0.3	0.6	1.4
Mean Putamen Volume	0.2	0.3	0.6	0.3	-0.4	-0.8
Fasting Glucose	1.5	1.8	4.1	-0.8	2.0	0.8
HbA1C	0.5	0.6	1.0	-0.8	1.0	-0.3
HDL Cholesterol	0.1	0.2	0.4	0.6	-0.2	-0.6
LDL Cholesterol	0.2	0.4	0.7	0.8	0.7	-0.1
Lupus	1.4	2.1	3.5	-0.6	-1.9	-1.6
Neuroticism (2016)	1.1	1.6	1.8	1.3	-1.3	1.1
Primary Biliary Cirrhosis	0.5	0.7	1.0	-0.8	-1.0	-0.6
Rheumatoid Arthritis	0.9	1.3	3.7	0.3	-1.9	0.2
Schizophrenia (2014)	0.8	1.9	4.1	-2.0	0.4	1.2
Triglycerides	0.5	0.9	1.4	0.8	0.8	1.2
Type 2 Diabetes (T2D) (2012)	5.2	6.1	10.0	1.8	-3.2	-2.2
Ulcerative Colitis	0.6	0.8	1.5	1.2	-0.7	-0.7
Blood Eosinophil Count	0.6	4.4	12.5	0.8	-3.5	0.2
Blood Platelet Count	0.0	0.2	0.3	0.4	0.5	0.5
Blood Red Count	1.2	11.6	27.2	5.2	1.1	2.5
Blood White Count	0.7	5.2	10.4	-0.4	3.2	2.3
Heel T-Score	0.5	3.7	5.8	0.0	-2.4	-2.3
BMI	0.3	1.5	1.8	-1.1	-1.4	-1.2
Height	0.1	2.7	3.7	-1.9	1.2	1.7
Waist Hip Ratio (WHR)	0.4	1.9	4.5	0.9	0.6	2.1
Systolic Blood Pressure	0.4	1.9	4.9	-2.2	0.6	0.7
Smoking Status	0.8	1.9	4.0	-2.0	1.3	0.2
Allergy or Eczema	1.7	4.3	11.7	3.4	-0.1	-1.1
Cardiovascular Disease	0.1	0.3	0.6	0.4	-0.8	0.4
Hypothyroidism (self reported)	1.5	3.4	5.7	-0.7	2.0	-2.4
Respiratory disease	1.4	3.0	9.0	3.0	0.0	-0.2
Type 2 Diabetes (T2D) (2018)	1.5	2.9	4.0	1.9	-2.0	-1.1
Lung FEV1/FVC ratio	0.6	3.1	7.0	-1.3	-0.7	-2.6
Lung FVC	0.3	1.4	2.0	-0.5	1.4	1.4
Neuroticism	2.5	5.9	9.9	3.1	-0.6	-2.7
Chronotype (morning person)	1.0	2.4	5.2	1.1	-0.9	-2.3
Hair Pigment	0.3	9.3	14.4	-3.3	1.6	3.8
Tanning	0.2	2.0	5.3	0.3	0.7	2.3
Hand grip strength (left)	1.0	2.7	6.0	-2.4	1.3	0.8
Number of treatments/medications taken	0.1	0.1	0.3	0.5	-0.2	-0.2
Average weekly spirits intake	0.4	0.5	0.8	0.5	0.7	-0.9
Sensitivity / hurt feelings	0.9	1.6	2.8	1.7	-0.2	1.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.4	0.5	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	2.2	-0.5	1.5	0.8
Relative age of first facial hair	0.5	1.1	1.7	1.0	-1.3	0.8
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.7	-0.9	0.5	1.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	1.2	-0.6	-0.3
Ever had hysterectomy (womb removed)	1.0	1.2	2.5	1.6	0.5	-0.8
Systolic blood pressure, automated reading	0.7	1.9	3.6	-1.2	-1.9	-0.9
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	7.9	1.2	-1.5	-2.8
Angina	0.3	0.5	0.6	-0.7	0.8	-0.5
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.5	0.5	0.9
Vitamin and mineral supplements	0.7	1.0	2.0	-0.7	0.6	-1.4
Supplements: Zinc	3.6	4.0	6.1	1.3	-2.5	-2.1
Medication: Co-codamol	4.0	4.7	12.2	1.3	0.1	-3.5
Medication: Metformin	5.2	7.4	11.2	3.2	-3.3	-0.7
Diabetes (father)	2.6	3.2	8.8	3.0	0.3	-0.9
Diabetes (mother)	1.3	1.7	3.2	-0.6	1.8	1.2
Severe depression (siblings)	0.4	0.5	1.3	1.1	0.4	0.1
Pack years adult smoking proportion	0.9	1.3	3.0	-0.9	1.7	-0.4
Impedance of leg (right)	1.8	8.9	19.2	4.4	-2.7	-0.7
Leg fat-free mass (left)	0.5	2.6	4.7	-2.2	0.7	1.6
Trunk fat percentage	1.8	7.2	11.7	2.9	-3.4	-1.3
Hand grip strength (right)	1.9	5.1	10.1	-3.2	1.7	1.5
Townsend deprivation index at recruitment	0.8	1.2	2.4	0.9	-1.6	0.6
Current tobacco smoking	3.4	5.6	9.9	-3.1	2.2	1.4
Average weekly fortified wine intake	0.4	0.4	1.3	0.0	-0.1	1.1
Maternal smoking around birth	0.6	0.9	1.6	-1.2	0.9	0.5
Fed-up feelings	1.8	3.2	7.2	1.0	1.2	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.8	0.9	-0.8	-1.4
Relative age voice broke	1.4	2.2	4.2	1.5	-2.0	-0.3
Taking other prescription medications	0.2	0.3	0.7	0.8	-0.5	0.0
Age when periods started (menarche)	0.6	1.4	2.3	-1.1	-1.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	1.3	0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.8	-1.7	-1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.5	0.5	-1.6	-1.4
Qualifications: CSEs or equivalent	1.6	2.1	5.6	-0.7	0.2	2.4
Serious illness, injury or assault to yourself	0.0	0.1	0.1	-0.3	-0.0	0.2
High blood pressure	0.5	1.4	3.4	0.4	-1.9	-0.7
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.0	2.2	-0.2	-0.8
Multivitamins +/- minerals	0.2	0.2	0.4	0.2	-0.7	0.5
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.4	0.4	1.2
Supplements: Glucosamine	1.9	2.4	5.7	0.3	-2.4	-1.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.0	-1.0	0.9	0.7
Medication: Atenolol	0.8	0.9	1.7	-1.0	-0.2	-1.3
Medication: Levothyroxine sodium	1.1	1.9	5.3	0.0	0.7	-2.3
Sitting height	0.8	6.0	9.6	-3.1	1.4	2.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	-0.5	-0.9	-0.4
High blood pressure (mother)	0.3	0.4	0.9	0.5	-0.1	-0.9
Body mass index (BMI)	0.3	1.4	3.2	-0.7	-1.8	-0.8
Impedance of leg (left)	1.2	5.7	13.5	3.7	-1.9	-0.2
Leg predicted mass (left)	0.5	2.5	4.4	-2.1	0.7	1.6
Trunk fat mass	0.8	3.3	7.3	1.5	-2.7	-0.7
Waist circumference	0.3	0.9	2.0	0.4	-1.4	0.7
Number of incorrect matches in round	0.4	0.6	1.6	1.3	-0.3	0.3
Past tobacco smoking	0.0	0.0	0.1	0.1	-0.2	0.3
Alcohol usually taken with meals	1.1	1.8	3.0	1.7	-1.5	-0.2
Nervous feelings	0.8	1.5	1.9	1.4	-1.1	-1.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	7.9	2.8	-0.4	-1.2
Hearing difficulty/problems with background noise	0.5	0.8	1.2	1.1	1.1	-0.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.6	0.2	1.3	0.7
Had menopause	2.9	3.7	8.5	2.9	-1.1	-1.1
Had other major operations	1.4	1.7	2.3	-1.3	1.5	1.1
Forced vital capacity (FVC)	1.5	5.8	8.9	-2.2	1.8	3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	5.7	-2.4	-0.9	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.0	0.3	-1.1
Qualifications: None of the above	0.2	0.4	1.1	-0.0	-0.3	-1.1
Financial difficulties in last 2 years	1.3	1.7	3.3	1.0	-1.8	-0.9
Mouth/teeth dental problems	1.7	2.5	4.2	-1.8	0.1	2.1
Heart attack	0.3	0.4	0.8	0.9	0.6	0.0
Allergy	2.8	6.4	18.3	-4.3	0.2	0.9
Pain all over the body in last month	1.4	1.5	3.4	0.8	0.7	-1.8
Diabetes (self-reported)	2.8	4.3	6.6	2.6	-2.3	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.5	-0.7	-0.5
Medication: Ramipril	2.6	3.3	7.0	2.6	-1.6	-0.6
Medication: Simvastatin	1.4	2.1	3.0	1.7	-0.8	-1.6
Fluid intelligence score	1.7	3.4	5.4	2.3	-2.0	-0.9
Illnesses of siblings	0.3	0.5	0.8	0.2	-0.9	-0.8
Neuroticism score	0.9	1.9	2.8	1.7	0.3	-1.6
Weight	0.2	1.0	1.9	-0.9	-1.4	0.5
Impedance of arm (right)	2.4	11.1	27.6	5.3	-2.2	-1.0
Arm fat percentage (right)	1.1	4.3	8.9	1.6	-3.0	-1.3
Trunk fat-free mass	1.6	9.0	17.1	-4.1	1.7	2.6
Hip circumference	0.2	0.7	1.9	0.0	-1.4	0.3
Time employed in main current job	0.7	0.8	2.0	0.5	-1.4	0.2
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-0.0	-0.6	1.0
Father’s age at death	1.6	2.1	4.0	0.5	-2.0	-1.5
Worrier / anxious feelings	0.4	0.8	2.1	1.4	-0.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.0	0.7	-0.3	-1.4
Falls in the last year	0.1	0.1	0.2	0.3	0.3	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.2	0.5	-0.2
Number of live births	0.3	0.4	0.6	0.2	-0.7	0.8
Forced expiratory volume in 1-second (FEV1)	1.3	4.2	5.7	-2.4	1.2	2.4
Pulse rate	0.5	0.9	2.5	-1.6	0.2	0.3
Happiness	0.4	0.5	1.5	0.4	-0.1	-1.2
Noisy workplace	0.8	1.0	1.6	0.4	1.3	-1.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.6	-1.5	1.1	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	5.6	2.4	-0.8	0.3
Mouth/teeth dental problems: Dentures	3.0	5.1	11.3	1.6	-1.2	-3.4
Asthma	1.3	2.6	7.7	2.8	0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	4.0	-2.0	0.4	0.4
Medication: Cholesterol lowering	0.6	1.0	2.7	1.7	-0.4	-0.2
Depression (self-reported)	3.2	3.8	9.4	0.9	-1.1	-3.1
Medication: Lansoprazole	1.5	1.7	3.6	1.9	-1.2	0.2
Prospective memory result	2.3	2.9	7.6	-2.8	-0.2	1.0
Lung cancer (father)	0.4	0.5	1.3	-0.1	0.4	1.1
Illnesses of mother	0.3	0.4	1.1	0.1	-0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	3.8	-1.9	1.6	1.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	0.7	-0.1
Impedance of arm (left)	2.3	10.7	28.3	5.3	-1.7	-0.9
Arm fat mass (right)	0.4	1.6	4.4	0.1	-2.1	-0.6
Trunk predicted mass	1.6	9.0	16.9	-4.1	1.7	2.7
Standing height	0.4	4.0	10.0	-1.0	0.9	3.2
Length of working week for main job	1.4	1.6	2.7	1.6	0.4	-1.4
Exposure to tobacco smoke at home	1.8	2.0	4.3	0.3	-1.2	-2.1
Breastfed as a baby	0.7	0.9	1.3	1.0	-0.6	-1.1
Tense / ‘highly strung’	0.2	0.4	1.0	0.2	0.2	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	0.2	0.6	-1.1
Hair/balding pattern: Pattern 4	0.9	2.1	3.2	1.8	-1.7	-0.0
Birth weight of first child	0.7	1.3	2.1	0.9	-1.0	-1.4
Peak expiratory flow (PEF)	1.1	2.6	4.5	-1.6	1.0	2.1
Pulse wave reflection index	1.0	1.3	3.6	0.3	1.9	0.3
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.1	1.1	-0.8	-0.7
Loud music exposure frequency	1.0	1.1	1.9	0.7	-0.9	-1.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.7	-1.6	1.4	0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	1.3	-0.3	0.1
Blood clot in the leg (DVT)	0.8	1.0	2.3	1.5	0.1	0.9
Medication: Paracetamol	0.5	0.8	1.6	-1.3	0.7	-0.4
Headache pain in last month	0.7	1.2	3.2	-0.4	1.8	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.9	-0.2	-0.2
Glaucoma (self-reported)	0.5	0.6	1.1	-0.9	-0.1	1.0
Gout (self-reported)	0.8	1.2	2.3	-0.6	-1.5	0.9
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.8	-0.6	0.8	-2.2
Medication: Amlodipine	0.5	0.7	1.0	-1.0	-0.3	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	0.9	0.5	-0.5
Birth weight	0.1	0.3	0.5	-0.5	-0.1	-0.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.2	1.0	-1.5	-1.8
High blood pressure (siblings)	0.4	0.5	1.6	-0.0	0.0	1.3
Forced vital capacity (FVC), Best measure	1.3	4.8	6.9	-1.9	2.0	2.6
Body fat percentage	1.9	7.5	13.2	2.7	-3.6	-1.4
Leg fat percentage (right)	2.3	8.5	16.4	2.5	-4.0	-1.7
Arm fat-free mass (right)	1.1	5.4	11.3	-3.4	1.0	1.9
Exposure to tobacco smoke outside home	1.5	2.0	3.2	1.7	-1.8	0.3
Comparative body size at age 10	0.7	2.0	3.2	0.5	-1.6	-1.8
Number of full brothers	1.0	1.2	2.0	-1.4	0.6	1.2
Worry too long after embarrassment	2.3	3.8	7.8	2.8	-1.2	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.6	0.5	-0.7
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.3	0.2	0.3
Number of children fathered	0.3	0.4	1.0	0.2	1.0	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.8	-1.3	-1.2	0.1
Age at first live birth	0.8	1.4	2.9	-1.7	-0.3	1.2
Pulse wave peak to peak time	0.2	0.2	0.5	0.5	-0.7	0.1
Health satisfaction	1.8	2.3	4.0	1.7	-0.2	-2.0
Shortness of breath walking on level ground	1.0	1.2	3.4	0.1	0.3	-1.9
Qualifications: College or University degree	0.5	1.7	3.6	1.0	-0.6	1.9
Eye problems/disorders: None of the above	0.9	1.0	1.8	1.1	0.1	1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.4	3.5	1.9	0.1	-0.8
Emphysema/chronic bronchitis	1.1	1.2	2.2	1.5	1.2	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.8	1.3	1.0	-1.2	-0.1
Neck or shoulder pain in last month	0.3	0.4	0.8	0.0	0.9	0.7
Medication: Blood pressure	0.2	0.3	0.6	-0.2	0.8	0.6
Angina (self-reported)	0.3	0.4	0.5	-0.7	0.6	-0.6
Migraine (self-reported)	4.4	5.5	7.8	-2.8	2.8	1.0
Medication: Ibuprofen	1.3	1.5	2.7	-1.6	1.2	0.7
Medication: Allopurinol	1.6	2.1	4.1	-1.4	-0.6	2.0
Medication: Omeprazole	0.4	0.5	1.5	0.4	1.2	-0.1
Medication: Seretide 50 evohaler	1.2	1.4	1.9	0.5	1.4	1.4
Mean time to correctly identify matches	2.4	4.6	5.0	2.1	-2.1	-2.2
Heart disease (mother)	0.9	1.1	3.4	0.0	-0.1	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.0	0.9	-1.7	-0.2
Whole body fat mass	0.7	3.0	7.5	1.2	-2.7	-0.5
Leg fat mass (right)	0.8	3.1	8.0	0.8	-2.8	-0.7
Arm predicted mass (right)	1.2	6.2	11.7	-3.4	1.2	2.3
Pulse rate, automated reading	0.4	1.4	2.2	-1.4	-1.5	-0.2
Alcohol intake frequency.	0.4	0.9	1.5	-1.2	1.1	-0.2
Comparative height size at age 10	0.1	0.7	1.2	-0.9	0.4	1.1
Number of full sisters	0.6	0.7	1.3	0.4	-0.8	1.1
Suffer from ‘nerves’	1.0	1.6	2.7	1.4	-1.6	-0.1
Overall health rating	1.2	2.7	4.3	1.9	-0.3	-2.1
Chest pain or discomfort	0.3	0.5	1.1	0.3	1.1	-0.5
Had major operations	0.5	0.6	1.5	1.2	-0.5	0.2
Age at last live birth	0.6	0.8	2.0	-0.4	-1.4	0.4
Family relationship satisfaction	0.3	0.3	0.8	0.9	0.0	0.5
Leg pain on walking	2.1	2.7	4.6	-2.1	1.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	-0.1	1.4	-0.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.6	-1.9	0.4	-0.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.8	0.0	1.3	-0.7
Medication: Aspirin	0.2	0.2	0.4	0.6	-0.6	0.2
Supplements: Vitamin C	0.6	0.8	1.3	0.7	-1.1	0.7
Knee pain experienced in last month	0.4	0.6	1.6	0.2	-0.5	-1.2
Hypertension (Self-reported)	0.5	1.5	3.0	0.7	-1.7	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	4.0	2.0	0.5	-0.2
Illnesses of father: Heart disease	0.5	0.7	1.6	1.3	0.1	0.6
Illnesses of siblings: Diabetes	1.0	1.2	2.3	1.5	-0.4	-1.1
Smoking status: Previous	0.4	0.6	1.1	1.0	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.0	0.3	-0.6	1.7
Whole body fat-free mass	1.2	6.9	12.7	-3.6	1.6	2.4
Leg fat-free mass (right)	0.8	4.2	7.5	-2.7	1.4	1.8
Arm fat percentage (left)	1.1	4.5	8.0	1.8	-2.8	-1.5
Average weekly red wine intake	1.8	2.6	4.3	2.1	-1.7	-0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.0	1.0	0.8	0.8
Mood swings	0.1	0.2	0.5	0.4	0.7	-0.2
Loneliness, isolation	2.2	3.0	7.7	0.7	2.8	-0.9
Long-standing illness, disability or infirmity	1.2	1.9	2.8	0.8	-1.5	-1.7
Ever had bowel cancer screening	0.3	0.3	0.7	0.8	-0.0	-0.5
Diabetes diagnosed by doctor	2.8	4.6	6.6	2.5	-2.6	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.0	-0.3	1.4	1.0
Friendships satisfaction	0.5	0.6	1.4	1.2	0.4	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.9	-0.1	-0.1
Commuting to job workplace: Walk	2.0	2.2	5.8	2.4	-0.6	-0.7
Eye problems/disorders: Cataract	0.4	0.4	0.8	-0.9	0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.2	0.3	0.2
Medication for cholesterol	0.3	0.5	0.9	-0.4	1.0	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	0.3	0.1	-1.7
Back pain experienced in last month	0.6	0.9	2.0	-1.4	0.0	0.8
Mineral and other dietary supplements	0.3	0.4	1.2	-0.2	1.1	0.1
Breast cancer (self-reported)	1.7	2.0	3.4	-1.0	1.8	-1.3
Asthma (self-reported)	1.1	2.2	6.6	2.6	-0.1	-0.3
Osteoporosis (self-reported)	0.5	0.6	0.8	0.8	0.9	0.7
Osteoarthritis (self-reported)	0.1	0.2	0.2	-0.4	0.4	-0.5
Medication: Aspirin	0.5	0.6	1.3	0.7	-1.1	-0.1
Medication: Gliclazide	2.6	2.9	4.5	1.5	-2.1	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	-0.1	-1.2	-1.2
Smoking status: Current	2.9	4.6	8.4	-2.9	2.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.5	0.9	0.5
Whole body water mass	1.2	7.0	13.1	-3.6	1.5	2.4
Leg predicted mass (right)	0.8	4.3	7.6	-2.8	1.4	1.8
Arm fat mass (left)	0.3	1.1	3.2	0.0	-1.8	-0.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	0.3	-0.4	-0.9
Average weekly champagne plus white wine intake	1.1	1.5	4.2	2.1	0.5	-0.2
Miserableness	1.1	1.9	5.5	-0.4	2.4	0.1
Guilty feelings	1.3	1.9	3.8	1.9	-0.9	-1.0
Wears glasses or contact lenses	1.4	1.6	3.5	1.9	0.0	-1.1
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.7	0.8	-0.2
Hearing aid user	0.2	0.2	0.3	-0.4	0.6	0.3
Mother’s age at death	0.7	0.9	1.3	0.5	-1.1	-1.0
Financial situation satisfaction	2.0	2.4	4.7	2.2	0.4	-1.6
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.2	-0.7	1.8	1.0
Commuting to job workplace: Public transport	0.7	0.8	0.9	1.0	-0.8	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.5	-0.7	1.1
Medication: Blood pressure	0.6	1.2	1.8	0.8	-1.1	-1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.5	0.9	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.4	-1.0	0.2
High cholesterol (Self-reported)	0.5	1.0	1.6	1.1	-1.3	0.3
Medication: Bendroflumethiazide	1.2	1.8	3.3	0.4	-1.8	-1.4
Medication: Paracetamol	0.4	0.7	0.9	-0.7	0.9	-0.8
Medication: Lisinopril	0.1	0.1	0.2	0.5	0.1	0.3
Medication: Atorvastatin	0.7	0.8	1.5	1.2	-0.2	1.0
Illnesses of father: High blood pressure	1.9	2.3	3.7	-0.9	1.9	1.6
Alcohol drinker status: Never	0.2	0.2	0.5	-0.3	-0.2	0.7
Ever smoked	0.2	0.4	1.1	-1.0	0.0	0.3
Basal metabolic rate	0.8	4.3	8.7	-2.9	0.8	1.9
Leg fat percentage (left)	1.7	6.3	12.7	2.0	-3.6	-1.5
Arm fat-free mass (left)	1.2	5.9	11.3	-3.4	0.9	2.4
Number of operations (self-reported)	0.6	0.9	1.7	1.3	0.6	0.8
Average weekly beer plus cider intake	0.8	1.1	1.9	-0.3	-1.4	-1.2
Irritability	0.9	1.5	3.8	0.8	-0.2	-1.9
Risk taking	0.1	0.2	0.3	0.1	-0.5	0.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.0	-1.4	0.4	1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.6	-0.1	0.1	1.3
Age started oral contraceptive pill	0.2	0.3	0.3	0.6	-0.6	0.3
Diastolic blood pressure, automated reading	1.1	3.3	6.7	-2.6	-1.4	1.1
Ever depressed for a whole week	0.2	0.3	0.8	0.0	0.3	-0.9
Unable to work because of sickness or disability	0.6	0.7	2.0	1.4	-0.3	-0.2
Commuting to job workplace: Cycle	1.6	1.9	5.1	2.3	-0.2	-0.7
Myopia	2.3	3.4	4.7	2.2	-2.1	-0.9
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.9	-0.6	1.7	0.9
Cholesterol lowering medication	0.5	0.8	1.7	1.3	-0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	1.2	0.6	-0.4
Pain experienced in last month	0.3	0.6	1.6	-0.0	-0.2	1.3
Supplements: Calcium	0.6	0.7	1.9	1.4	0.1	0.3
Basal cell carcinoma (self-reported)	3.7	4.4	6.3	2.5	-2.0	-1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.9	0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.2	1.8	0.1	0.9
Heart disease (siblings)	0.3	0.3	0.7	-0.3	0.8	0.4
Alcohol drinker status: Previous	0.5	0.6	1.5	-0.4	0.0	-1.2
Pack years of smoking	1.2	1.7	3.6	-0.8	1.9	-1.0
Impedance of whole body	2.3	11.7	29.5	5.4	-2.2	-0.8
Leg fat mass (left)	0.6	2.3	6.5	0.5	-2.5	-0.5
Arm predicted mass (left)	1.2	6.3	13.1	-3.6	0.9	2.2