Hub : Genes

CTC-366B18.2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.227	0.094	0.0042	-0.011	NA	-0.008	NA	-0.008	0.92000	NA	0.6100	NA	0.60000
2	GTEx	Spleen	0.160	0.073	0.0046	0.114	NA	0.089	NA	0.137	0.00075	NA	0.0028	NA	0.00022
3	GTEx	Thyroid	0.060	0.028	0.0023	0.026	NA	0.014	NA	0.023	0.00430	NA	0.0280	NA	0.00620

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.6	-0.8	-0.7	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	-0.8	-0.1	1.0
Depressed Affect (Nagel 2018)	0.2	0.3	0.9	-0.1	1.0	0.1
Depression (Nagel 2018)	0.0	0.1	0.1	-0.4	-0.2	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.0	-0.8	1.2	1.4
Neuroticism (Nagel 2018)	1.3	3.1	6.5	-1.2	2.6	1.2
Schizophrenia (2018)	0.6	1.2	3.2	-0.4	0.5	1.8
Schizophrenia vs Biploar Disorder	2.4	3.1	5.6	-1.4	1.4	2.4
Worry (Nagel 2018)	2.0	4.1	7.1	-1.9	2.7	1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-1.2	-0.2	0.8
Alzheimer’s Disease (in father)	0.6	0.7	1.0	0.7	1.0	0.8
Alzheimer’s Disease (including proxy)	1.2	1.8	4.7	-0.2	0.8	2.2
Crohns Disease (2017)	0.3	0.6	1.1	0.2	1.1	-0.8
Irritable Bowel Disease (IBD)	0.7	1.8	4.4	0.8	-0.6	-2.1
Ulcerative Colitis (UC)	1.8	3.3	5.9	0.7	-1.9	-2.4
Major Depression (MDD)	0.6	0.7	1.2	-0.5	-1.1	-0.7
Reaction Time	0.9	1.7	4.9	-2.2	-0.2	-0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.2	0.3	1.1	0.9
Breast Cancer	1.3	3.2	4.1	-1.6	-2.0	-1.7
Ovarian Cancer	0.7	1.0	2.0	-1.4	-0.9	-0.4
Prostate Cancer	0.3	0.4	0.9	0.2	-1.0	-0.5
Age at First Birth	0.1	0.2	0.5	0.0	-0.7	0.3
Bipolar Disorder (2011)	0.0	0.0	0.1	0.3	-0.1	-0.1
Body Mass Index (BMI) (2010)	7.5	10.3	16.3	0.0	-3.8	-4.0
Coronary Artery Disease (CAD)	1.1	1.3	3.0	1.7	-0.5	0.9
Crohns Disease (2012)	2.1	3.4	6.7	2.6	1.7	-0.7
Mean Putamen Volume	1.0	1.2	1.4	-1.2	-1.1	1.0
Fasting Glucose	3.3	4.0	9.3	0.2	-1.6	-3.1
HbA1C	0.4	0.4	1.1	0.3	-1.1	0.2
HDL Cholesterol	1.1	1.8	3.7	0.1	1.9	1.4
LDL Cholesterol	29.1	46.0	85.0	0.9	7.2	9.2
Lupus	0.7	1.0	1.5	0.8	-1.2	1.0
Neuroticism (2016)	1.6	2.3	4.5	0.3	2.1	1.6
Primary Biliary Cirrhosis	0.3	0.4	1.1	-0.2	-1.1	0.2
Rheumatoid Arthritis	0.7	1.0	1.8	-1.0	-1.4	-0.4
Schizophrenia (2014)	0.9	2.0	4.6	-0.4	1.1	2.1
Triglycerides	0.3	0.4	1.1	1.1	-0.1	0.5
Type 2 Diabetes (T2D) (2012)	2.8	3.2	4.0	1.9	-2.0	-1.4
Ulcerative Colitis	2.7	3.9	5.1	2.3	-1.6	-2.0
Blood Eosinophil Count	0.0	0.1	0.1	-0.2	-0.4	-0.2
Blood Platelet Count	3.5	40.4	63.7	-2.1	8.0	7.3
Blood Red Count	0.0	0.4	1.0	0.1	0.1	1.0
Blood White Count	0.1	0.5	0.9	-0.9	0.4	-0.7
Heel T-Score	1.0	7.6	10.7	1.5	-3.3	-3.2
BMI	14.8	86.0	127.7	3.1	-11.3	-11.0
Height	0.5	10.0	18.0	1.9	-4.2	-2.9
Waist Hip Ratio (WHR)	0.0	0.2	0.3	-0.5	-0.6	-0.0
Systolic Blood Pressure	0.3	1.4	3.2	1.0	1.8	0.3
Smoking Status	3.0	7.1	7.8	2.8	-2.6	-2.6
Allergy or Eczema	0.3	0.7	1.7	-0.5	1.3	0.0
Cardiovascular Disease	2.8	9.2	15.9	1.4	4.0	3.1
Hypothyroidism (self reported)	1.4	3.3	5.0	1.7	-2.2	-1.3
Respiratory disease	0.3	0.6	1.7	-0.0	-1.3	0.1
Type 2 Diabetes (T2D) (2018)	3.4	6.4	9.5	0.5	-3.1	-3.1
Lung FEV1/FVC ratio	0.2	1.1	3.2	-0.2	0.1	-1.8
Lung FVC	1.2	6.1	10.7	0.1	3.3	2.8
Neuroticism	2.0	4.9	8.5	-1.1	2.9	2.2
Chronotype (morning person)	0.8	1.9	4.3	2.1	1.2	-0.0
Hair Pigment	0.3	7.4	12.0	0.3	3.5	3.2
Tanning	0.1	1.2	3.2	1.8	-0.4	-0.3
Hand grip strength (left)	0.5	1.3	2.6	-0.8	-1.6	-0.8
Number of treatments/medications taken	1.0	1.8	5.1	-0.3	0.2	2.3
Average weekly spirits intake	4.8	6.0	11.7	3.4	-1.9	-1.6
Sensitivity / hurt feelings	1.7	2.9	3.5	-1.8	1.4	1.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	-0.6	1.0	0.6
Hearing difficulty/problems: Yes	0.7	1.1	1.7	1.1	-1.3	0.6
Relative age of first facial hair	1.6	3.3	4.5	2.1	1.1	2.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.4	-0.2	0.8
Ever used hormone-replacement therapy (HRT)	1.6	2.0	5.6	0.1	2.4	0.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.3	1.0	-0.7
Systolic blood pressure, automated reading	0.2	0.6	0.9	0.9	-0.9	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.6	-0.3	0.2
Angina	1.3	1.7	2.7	1.4	-0.6	1.6
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.2	0.9	0.1
Vitamin and mineral supplements	0.2	0.2	0.5	-0.2	-0.7	-0.4
Supplements: Zinc	0.5	0.5	1.2	0.5	0.4	1.1
Medication: Co-codamol	0.4	0.5	1.2	0.3	-1.1	-0.4
Medication: Metformin	2.0	2.8	5.7	0.7	-2.4	-1.5
Diabetes (father)	3.1	3.8	6.0	-0.3	-2.4	-2.3
Diabetes (mother)	4.3	5.4	6.6	2.6	-2.2	-2.2
Severe depression (siblings)	0.4	0.5	1.4	1.2	-0.1	-0.1
Pack years adult smoking proportion	2.5	3.8	6.9	0.3	-2.1	-2.6
Impedance of leg (right)	5.6	27.0	47.6	-2.0	6.9	5.4
Leg fat-free mass (left)	13.0	69.0	110.2	3.6	-10.5	-9.2
Trunk fat percentage	7.5	30.1	46.0	1.2	-6.8	-6.6
Hand grip strength (right)	0.4	1.0	1.5	-0.5	-1.2	-1.2
Townsend deprivation index at recruitment	0.3	0.4	1.0	0.4	1.0	-0.3
Current tobacco smoking	3.8	6.2	11.3	0.7	-3.4	-2.6
Average weekly fortified wine intake	0.7	0.9	2.2	-1.5	0.1	0.7
Maternal smoking around birth	0.4	0.6	1.7	0.2	0.2	-1.3
Fed-up feelings	0.0	0.1	0.2	-0.0	0.4	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.1	-0.5	-0.5
Relative age voice broke	1.9	2.9	5.0	1.3	2.2	1.5
Taking other prescription medications	0.1	0.1	0.2	0.3	0.4	0.4
Age when periods started (menarche)	0.8	1.8	3.6	-0.2	1.4	1.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.7	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	7.2	0.5	-2.7	-1.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.9	1.2	-1.4	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	1.2	-1.1	-0.8	-0.3
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.4	-1.4	0.2
High blood pressure	0.4	1.1	1.8	1.2	1.4	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	-0.1	0.5	-1.2
Multivitamins +/- minerals	1.0	1.2	2.6	-0.8	-1.6	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.7	0.2	0.4
Supplements: Glucosamine	0.3	0.4	0.6	0.5	-0.8	-0.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.5	-0.9	1.4	1.6
Medication: Atenolol	0.0	0.0	0.1	-0.1	-0.3	0.2
Medication: Levothyroxine sodium	0.4	0.7	1.2	0.5	-1.1	-0.8
Sitting height	2.4	17.3	23.1	3.2	-4.8	-4.3
Chronic bronchitis/emphysema (father)	2.8	3.3	4.8	-1.2	-2.2	-1.9
High blood pressure (mother)	0.4	0.5	0.8	-0.5	0.7	0.9
Body mass index (BMI)	13.0	55.4	90.1	2.1	-9.5	-8.5
Impedance of leg (left)	6.1	29.6	52.3	-2.5	7.2	5.5
Leg predicted mass (left)	13.1	69.2	110.2	3.7	-10.5	-9.1
Trunk fat mass	11.3	48.5	76.0	2.2	-8.7	-8.0
Waist circumference	14.8	54.2	91.2	3.1	-9.6	-7.9
Number of incorrect matches in round	0.1	0.1	0.3	-0.6	0.0	0.1
Past tobacco smoking	0.6	1.1	2.7	-1.6	-0.5	0.6
Alcohol usually taken with meals	0.8	1.3	3.2	0.4	1.8	0.7
Nervous feelings	1.0	1.9	2.9	-0.5	1.7	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.7	-0.4	-0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.3	-0.0	0.6
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	0.3	0.1	0.3
Had menopause	0.7	0.9	1.3	0.7	1.0	1.1
Had other major operations	0.2	0.3	0.6	-0.6	-0.7	-0.1
Forced vital capacity (FVC)	0.2	0.7	1.6	1.3	-0.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	8.0	-0.4	-2.8	-1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.0	-0.3	-2.0	-0.9
Qualifications: None of the above	0.4	0.9	2.1	0.1	-1.4	-0.7
Financial difficulties in last 2 years	1.5	2.1	5.1	-2.2	-0.7	0.8
Mouth/teeth dental problems	0.2	0.4	0.5	-0.7	0.6	-0.5
Heart attack	1.4	1.8	2.5	0.9	1.4	1.6
Allergy	0.0	0.1	0.1	0.3	0.3	-0.1
Pain all over the body in last month	3.6	3.9	10.4	-3.2	-0.2	1.1
Diabetes (self-reported)	4.7	7.3	13.5	0.8	-3.7	-2.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.6	1.3	0.2
Medication: Ramipril	0.3	0.3	0.5	-0.7	0.7	0.3
Medication: Simvastatin	4.4	6.4	16.3	0.8	1.5	4.0
Fluid intelligence score	0.4	0.9	1.7	0.7	0.6	1.3
Illnesses of siblings	0.3	0.4	1.0	-0.5	0.3	1.0
Neuroticism score	2.1	4.4	5.8	-1.9	2.4	1.9
Weight	15.1	74.1	118.8	3.5	-10.9	-9.6
Impedance of arm (right)	5.5	25.8	44.9	-2.3	6.7	5.2
Arm fat percentage (right)	8.9	35.0	52.5	1.8	-7.0	-7.2
Trunk fat-free mass	9.9	56.8	87.5	4.6	-9.4	-7.8
Hip circumference	13.9	59.7	93.7	3.1	-9.7	-8.7
Time employed in main current job	1.8	2.1	4.2	-1.1	0.9	2.1
Alcohol intake versus 10 years previously	1.0	1.5	3.6	-0.4	-0.8	-1.9
Father’s age at death	0.7	1.0	1.5	1.0	0.6	-1.2
Worrier / anxious feelings	1.3	2.5	4.1	-1.1	2.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.3	0.1	0.8
Falls in the last year	0.4	0.5	0.8	-0.9	-0.7	-0.5
Hair/balding pattern: Pattern 3	0.7	1.0	2.1	1.4	0.3	-1.0
Number of live births	1.5	2.1	2.8	1.2	1.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.5	0.7	0.7	0.4
Pulse rate	4.9	8.2	11.1	-2.8	3.3	2.4
Happiness	0.7	0.9	1.5	0.3	1.2	1.0
Noisy workplace	1.3	1.6	3.8	-1.0	-1.9	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.7	0.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.3	-2.1	0.1	0.1
Mouth/teeth dental problems: Dentures	1.4	2.4	2.6	1.5	-1.4	-1.6
Asthma	0.3	0.6	1.2	-0.6	-1.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	0.5	-0.5	-1.5
Medication: Cholesterol lowering	8.8	13.7	27.9	1.1	3.5	5.3
Depression (self-reported)	1.6	1.9	2.7	-0.7	-1.6	-1.6
Medication: Lansoprazole	3.5	3.9	6.9	0.1	-2.6	-2.2
Prospective memory result	0.9	1.2	2.8	-1.7	-0.0	0.8
Lung cancer (father)	0.8	0.9	1.3	0.3	-1.1	-1.1
Illnesses of mother	0.6	0.7	1.8	-1.4	0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	0.4	-0.8	-0.9
Pulse wave Arterial Stiffness index	1.7	2.0	3.2	1.6	-1.8	-0.3
Impedance of arm (left)	5.9	27.4	41.0	-3.0	6.4	5.7
Arm fat mass (right)	14.2	58.5	89.3	2.6	-9.4	-8.9
Trunk predicted mass	10.0	57.2	88.0	4.5	-9.4	-7.9
Standing height	1.3	13.2	18.5	3.2	-4.3	-3.3
Length of working week for main job	0.6	0.7	1.0	-0.9	1.0	-0.5
Exposure to tobacco smoke at home	2.6	3.0	4.6	0.3	-2.0	-2.1
Breastfed as a baby	1.1	1.3	2.2	1.5	0.4	-1.3
Tense / ‘highly strung’	3.4	5.7	8.6	-1.4	2.9	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.1	-1.7	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.6	1.5	3.3	-0.8	0.7	1.8
Birth weight of first child	1.3	2.3	6.0	-0.4	2.4	0.9
Peak expiratory flow (PEF)	0.2	0.5	1.4	1.2	0.4	-0.1
Pulse wave reflection index	7.0	8.7	10.5	3.2	-3.2	-2.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.4	-0.4	-1.6	-1.0
Loud music exposure frequency	2.0	2.1	3.6	-1.9	-1.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.8	0.9	1.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.7	-0.2	1.3	1.3
Blood clot in the leg (DVT)	0.5	0.6	1.5	0.2	-0.5	1.2
Medication: Paracetamol	0.6	0.9	2.1	-0.3	1.4	0.8
Headache pain in last month	5.8	9.9	18.4	-1.3	4.3	3.1
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	10.6	-0.7	-2.5	-3.3
Glaucoma (self-reported)	0.2	0.2	0.6	0.8	0.1	0.2
Gout (self-reported)	2.7	3.7	4.9	-2.2	-2.0	-1.5
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	4.0	1.2	-2.0	-1.8
Medication: Amlodipine	0.2	0.3	0.6	0.8	0.1	0.5
Medication: Ventolin 100micrograms inhaler	2.5	3.2	5.1	0.2	-2.3	-2.1
Birth weight	1.0	2.2	4.1	-0.0	-1.6	-2.0
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.6	-1.6	0.9	0.5
High blood pressure (siblings)	0.3	0.4	0.7	0.6	-0.5	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.1	2.3	0.9	-1.5	-0.6
Body fat percentage	8.4	33.2	48.9	1.4	-7.0	-7.0
Leg fat percentage (right)	8.1	29.5	45.0	1.6	-6.7	-6.4
Arm fat-free mass (right)	12.3	63.0	102.0	4.0	-10.1	-8.4
Exposure to tobacco smoke outside home	0.2	0.2	0.6	-0.8	-0.3	-0.2
Comparative body size at age 10	3.9	10.8	14.4	2.1	-3.7	-3.8
Number of full brothers	0.3	0.3	0.7	0.8	-0.5	0.2
Worry too long after embarrassment	2.9	4.8	8.4	-0.6	2.9	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.3	-1.1	-1.0	-0.9
Wheeze or whistling in the chest in last year	2.2	4.0	6.7	1.7	-2.6	-1.5
Number of children fathered	1.0	1.2	2.5	1.6	-0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	0.5	0.3	1.2
Age at first live birth	0.3	0.6	0.7	-0.6	0.9	0.8
Pulse wave peak to peak time	1.2	1.4	2.2	-1.5	1.4	-0.1
Health satisfaction	0.5	0.7	1.6	-1.3	-0.4	0.4
Shortness of breath walking on level ground	1.2	1.4	3.3	-0.4	-1.8	-0.9
Qualifications: College or University degree	0.1	0.4	0.5	0.7	0.6	0.6
Eye problems/disorders: None of the above	0.3	0.4	0.6	-0.8	-0.4	-0.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.6	0.3	1.1	1.6
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.7	0.5	0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.6	-0.1	-0.7
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.2	0.1	0.1
Medication: Blood pressure	0.2	0.4	1.0	0.1	1.0	-0.2
Angina (self-reported)	1.4	1.9	3.4	1.3	-0.6	1.8
Migraine (self-reported)	6.1	7.5	11.8	-2.5	3.4	2.2
Medication: Ibuprofen	0.1	0.2	0.3	-0.0	0.5	-0.5
Medication: Allopurinol	1.0	1.4	2.1	-1.1	-1.5	-0.9
Medication: Omeprazole	0.4	0.5	0.6	-0.6	-0.7	0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.3	-0.3	-0.4
Mean time to correctly identify matches	0.5	1.0	1.7	-1.3	-0.1	1.2
Heart disease (mother)	1.2	1.5	2.0	1.4	-0.7	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.8	-0.3	0.9	0.9
Whole body fat mass	12.9	53.9	82.9	2.6	-9.1	-8.5
Leg fat mass (right)	14.7	56.8	87.6	2.8	-9.4	-8.7
Arm predicted mass (right)	12.3	62.7	99.7	4.1	-10.0	-8.5
Pulse rate, automated reading	3.9	12.5	19.7	-4.4	3.5	2.4
Alcohol intake frequency.	0.3	0.8	1.5	-0.6	-0.7	-1.2
Comparative height size at age 10	2.1	11.3	17.7	1.7	-4.2	-3.7
Number of full sisters	1.8	2.1	6.3	2.5	-0.2	-0.3
Suffer from ‘nerves’	1.3	2.0	3.4	-1.5	1.8	0.6
Overall health rating	1.4	3.1	8.6	-0.2	-2.9	-0.8
Chest pain or discomfort	0.4	0.6	1.6	1.3	0.4	0.2
Had major operations	0.1	0.2	0.4	0.2	0.2	0.6
Age at last live birth	0.3	0.5	0.8	-0.4	0.7	0.9
Family relationship satisfaction	0.6	0.8	1.8	1.3	-0.3	-0.7
Leg pain on walking	1.5	1.8	3.8	-0.4	-1.2	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.7	-0.1	-1.1	-1.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.9	-0.8	-0.9	-0.7
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.7	2.2	-0.4	-0.8
Medication: Aspirin	0.7	0.9	2.7	0.3	-0.1	1.6
Supplements: Vitamin C	2.8	3.4	7.1	2.7	1.7	0.5
Knee pain experienced in last month	0.2	0.4	0.7	0.2	-0.6	0.8
Hypertension (Self-reported)	0.4	1.0	2.3	0.8	1.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-1.1	-0.2	0.5
Illnesses of father: Heart disease	0.4	0.5	1.1	-1.1	-0.1	0.7
Illnesses of siblings: Diabetes	0.5	0.7	1.4	-0.2	-1.2	-0.7
Smoking status: Previous	1.1	1.7	2.9	1.3	1.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	8.8	1.3	-2.3	-3.0
Whole body fat-free mass	11.6	66.3	104.0	4.3	-10.2	-8.8
Leg fat-free mass (right)	12.0	64.1	104.0	3.2	-10.2	-8.8
Arm fat percentage (left)	8.9	35.5	53.9	1.6	-7.3	-7.1
Average weekly red wine intake	0.2	0.3	0.8	0.9	0.3	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.5	0.6	0.5	0.7
Mood swings	0.8	1.4	2.6	-0.0	1.6	1.2
Loneliness, isolation	0.3	0.4	0.5	-0.7	0.7	-0.7
Long-standing illness, disability or infirmity	1.4	2.2	3.4	1.3	-1.8	-1.1
Ever had bowel cancer screening	0.1	0.1	0.3	0.3	0.1	-0.5
Diabetes diagnosed by doctor	3.1	5.2	9.4	1.0	-3.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	-0.1	-0.4
Friendships satisfaction	3.7	4.6	7.8	1.1	2.8	2.2
Qualifications: nursing, teaching	0.6	1.0	2.5	1.6	-0.5	0.4
Commuting to job workplace: Walk	1.8	1.9	2.1	1.4	1.3	1.4
Eye problems/disorders: Cataract	1.1	1.2	3.1	0.2	0.7	1.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.9	0.6	-2.0	-0.2
Medication for cholesterol	2.4	3.6	8.2	-1.0	-1.3	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	-0.4	1.4	0.3
Back pain experienced in last month	0.0	0.1	0.2	0.1	-0.2	-0.4
Mineral and other dietary supplements	0.3	0.5	1.0	1.0	-0.3	-0.5
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.2
Asthma (self-reported)	0.3	0.5	1.1	-0.6	-1.1	0.4
Osteoporosis (self-reported)	1.9	2.3	3.8	-0.4	1.7	1.9
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.2	0.7	0.6
Medication: Aspirin	0.8	1.0	3.0	0.1	-0.3	1.7
Medication: Gliclazide	3.1	3.5	8.1	-0.1	-2.8	-1.5
Illnesses of father: None of the above (group 1)	1.3	1.7	4.4	-0.0	0.8	2.1
Smoking status: Current	4.8	7.6	11.4	1.3	-3.4	-3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	-1.3	0.8	-0.1
Whole body water mass	11.8	67.1	106.1	4.2	-10.3	-8.8
Leg predicted mass (right)	12.1	64.3	104.0	3.2	-10.2	-8.9
Arm fat mass (left)	13.8	56.5	88.2	2.6	-9.4	-8.6
Number of self-reported non-cancer illnesses	0.6	1.1	2.6	-0.5	0.6	1.6
Average weekly champagne plus white wine intake	0.9	1.2	1.9	1.3	0.1	-1.4
Miserableness	1.7	3.0	3.9	-1.5	1.7	2.0
Guilty feelings	1.2	1.9	2.5	-0.9	1.5	1.6
Wears glasses or contact lenses	0.2	0.3	0.6	-0.2	-0.4	-0.8
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.3	0.1	-0.8
Hearing aid user	0.0	0.0	0.1	0.3	-0.3	-0.1
Mother’s age at death	0.5	0.7	1.0	1.0	0.7	-0.7
Financial situation satisfaction	0.3	0.4	0.9	1.0	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.7	1.3	0.8	0.5
Commuting to job workplace: Public transport	0.3	0.4	0.9	0.9	0.5	0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	1.3	-0.0	-0.2
Medication: Blood pressure	0.5	1.0	1.8	1.3	0.1	1.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.3	-0.0	0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	-0.8	0.7	0.4
High cholesterol (Self-reported)	19.6	34.8	71.4	1.6	5.5	8.4
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.9	0.1	-0.5
Medication: Paracetamol	0.9	1.4	1.6	-1.2	1.0	1.3
Medication: Lisinopril	0.0	0.0	0.1	-0.2	-0.2	-0.1
Medication: Atorvastatin	12.1	15.0	29.6	0.6	3.9	5.4
Illnesses of father: High blood pressure	0.4	0.4	0.5	-0.7	0.6	-0.7
Alcohol drinker status: Never	0.5	0.6	0.8	-0.8	0.5	0.9
Ever smoked	0.2	0.4	0.6	0.6	-0.3	-0.8
Basal metabolic rate	13.2	73.3	116.6	4.1	-10.8	-9.3
Leg fat percentage (left)	8.4	30.4	46.5	1.5	-6.8	-6.5
Arm fat-free mass (left)	12.7	64.5	97.6	4.3	-9.9	-8.8
Number of operations (self-reported)	0.1	0.2	0.3	-0.4	-0.5	-0.1
Average weekly beer plus cider intake	0.9	1.3	2.5	-0.9	-1.6	-0.7
Irritability	1.5	2.6	6.8	-0.3	2.6	0.8
Risk taking	0.5	0.7	1.6	-0.7	-0.4	-1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.6	-0.6	0.6	1.3
Fractured/broken bones in last 5 years	0.8	1.0	1.8	-1.1	-0.3	1.3
Age started oral contraceptive pill	0.3	0.4	1.1	0.1	-1.0	-0.3
Diastolic blood pressure, automated reading	1.6	5.1	5.9	-1.9	2.4	2.4
Ever depressed for a whole week	1.5	1.9	2.9	-0.7	-1.7	-1.5
Unable to work because of sickness or disability	0.8	1.0	2.1	-0.6	-1.5	0.7
Commuting to job workplace: Cycle	0.4	0.5	1.2	1.1	-0.2	0.5
Myopia	4.4	6.4	14.5	3.8	-1.3	-1.8
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.6	-1.6	-1.3	-0.5
Cholesterol lowering medication	7.9	11.6	29.2	-0.5	2.3	5.4
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.2	-1.5	-1.1	1.4
Pain experienced in last month	0.9	1.5	2.2	1.5	-0.9	-1.2
Supplements: Calcium	1.5	1.7	3.2	1.8	0.1	-1.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.3	0.3	0.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.7	1.1	1.2	1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	0.2	-0.3	1.2
Heart disease (siblings)	0.1	0.1	0.2	0.4	-0.1	0.4
Alcohol drinker status: Previous	0.0	0.0	0.1	-0.2	-0.3	-0.1
Pack years of smoking	1.7	2.5	5.1	0.3	-1.5	-2.3
Impedance of whole body	7.2	36.7	60.3	-3.3	7.8	6.2
Leg fat mass (left)	14.8	57.8	88.2	2.8	-9.4	-8.8
Arm predicted mass (left)	13.3	67.6	102.0	4.6	-10.1	-8.9