Hub : Genes

CTC-428G20.3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cortex 0.230 0.0910 6.4e-03 0.050 NA 0.044 NA 0.007 1.7e-02 NA 2.4e-02 NA 2.1e-01
2 GTEx Esophagus Muscularis 0.142 0.0540 1.6e-03 0.069 NA -0.001 NA 0.014 5.4e-05 NA 4.1e-01 NA 4.5e-02
3 ROSMAP Brain Pre-frontal Cortex 0.115 0.0341 2.9e-06 0.068 0.051 0.061 0.062 0.080 4.1e-09 3.1e-07 2.3e-08 2.1e-08 1.6e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.4 2.2 2.6 -1.2 -1.6 -1.6
Bipolar Disorder or Schizophrenia 0.3 0.8 1.1 -0.6 -1.1 -1.0
Depressed Affect (Nagel 2018) 0.8 1.7 2.2 -1.1 1.4 1.5
Depression (Nagel 2018) 0.2 0.3 0.9 0.9 0.2 0.2
Intelligence (Savage-Jansen 2018) 0.4 1.1 1.5 -1.2 -0.8 -1.0
Neuroticism (Nagel 2018) 0.6 1.4 1.9 -0.7 1.4 1.4
Schizophrenia (2018) 0.0 0.0 0.0 0.1 -0.1 0.0
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 1.1 0.4 0.2
Worry (Nagel 2018) 0.6 1.3 1.6 -1.0 1.3 1.2
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 -0.7 -0.2 -0.1
Alzheimer’s Disease (in father) 1.0 1.1 1.2 1.1 0.9 1.1
Alzheimer’s Disease (including proxy) 1.0 1.5 2.6 -0.4 1.3 1.6
Crohns Disease (2017) 2.5 5.5 8.8 0.9 2.6 3.0
Irritable Bowel Disease (IBD) 3.3 7.8 12.4 0.4 3.3 3.5
Ulcerative Colitis (UC) 2.0 3.7 5.5 -0.6 2.3 2.4
Major Depression (MDD) 0.1 0.1 0.1 0.0 -0.3 -0.3
Reaction Time 0.2 0.5 1.4 1.2 -0.0 -0.1
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.5 -0.6 -1.0 -1.2
Breast Cancer 0.0 0.1 0.1 -0.3 0.2 0.2
Ovarian Cancer 0.2 0.2 0.3 -0.6 0.4 0.4
Prostate Cancer 0.5 0.7 1.8 -1.4 0.3 0.3
Age at First Birth 0.5 0.8 1.3 -1.1 0.8 0.7
Bipolar Disorder (2011) 0.5 0.4 0.7 -0.4 -0.8 -0.7
Body Mass Index (BMI) (2010) 0.3 0.4 0.5 0.6 -0.6 -0.7
Coronary Artery Disease (CAD) 0.6 0.7 2.1 1.4 0.1 0.2
Crohns Disease (2012) 1.4 2.3 3.1 0.7 1.8 1.8
Mean Putamen Volume 2.2 2.5 3.0 1.7 -1.4 -1.6
Fasting Glucose 0.8 0.9 1.6 -0.1 1.2 1.1
HbA1C 1.5 1.7 2.5 -0.3 1.6 1.6
HDL Cholesterol 0.2 0.3 0.5 -0.7 0.4 0.4
LDL Cholesterol 0.2 0.4 1.1 -1.0 0.1 0.0
Lupus 0.1 0.2 0.3 -0.4 0.3 0.5
Neuroticism (2016) 0.1 0.1 0.2 0.3 0.1 0.4
Primary Biliary Cirrhosis 0.8 1.1 1.6 -0.6 1.1 1.3
Rheumatoid Arthritis 1.0 1.4 2.0 -0.6 -1.4 -1.3
Schizophrenia (2014) 0.1 0.3 0.4 -0.4 -0.6 -0.6
Triglycerides 0.2 0.3 0.4 0.6 -0.4 -0.6
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.6 -0.8 0.2 0.0
Ulcerative Colitis 0.9 1.4 2.3 0.1 1.3 1.5
Blood Eosinophil Count 0.6 4.4 6.9 0.1 -2.5 -2.6
Blood Platelet Count 0.3 3.5 8.5 -2.9 0.9 1.0
Blood Red Count 0.1 0.9 1.4 -0.3 -1.1 -1.2
Blood White Count 0.2 1.3 1.9 -0.3 -1.4 -1.4
Heel T-Score 0.1 1.1 3.3 1.8 -0.1 -0.2
BMI 1.3 7.7 13.8 3.7 -2.0 -2.3
Height 0.2 3.0 4.6 1.8 -2.1 -1.1
Waist Hip Ratio (WHR) 0.3 1.4 4.1 -2.0 -0.0 0.1
Systolic Blood Pressure 1.0 5.1 11.7 3.4 -1.5 -1.2
Smoking Status 0.2 0.5 1.0 1.0 -0.5 -0.5
Allergy or Eczema 0.0 0.1 0.2 -0.5 -0.2 0.1
Cardiovascular Disease 3.3 10.8 11.3 3.4 -3.3 -3.2
Hypothyroidism (self reported) 0.1 0.3 0.4 0.7 -0.5 -0.4
Respiratory disease 0.3 0.6 0.9 -0.4 -0.9 -1.0
Type 2 Diabetes (T2D) (2018) 0.2 0.5 1.1 1.1 -0.1 -0.5
Lung FEV1/FVC ratio 0.3 1.5 2.7 0.8 -1.1 -1.6
Lung FVC 0.4 2.2 4.4 -2.1 0.8 1.2
Neuroticism 0.6 1.3 1.7 -1.0 1.3 1.2
Chronotype (morning person) 4.0 9.2 12.5 -2.1 3.5 3.3
Hair Pigment 0.0 0.5 0.7 -0.6 0.7 0.8
Tanning 0.3 3.6 5.3 -0.8 2.2 2.3
Hand grip strength (left) 0.2 0.4 0.6 0.8 -0.7 -0.4
Number of treatments/medications taken 8.9 15.9 26.4 5.1 -3.2 -3.4
Average weekly spirits intake 0.1 0.2 0.4 0.6 -0.2 -0.2
Sensitivity / hurt feelings 0.1 0.2 0.3 -0.0 0.5 0.6
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 0.7 0.2 0.2
Hearing difficulty/problems: Yes 2.5 3.9 6.5 0.2 -2.3 -2.5
Relative age of first facial hair 1.1 2.3 3.2 1.4 -1.3 -1.8
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.5 -0.3 -1.1 -1.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.3 -0.1 -0.5
Ever had hysterectomy (womb removed) 0.7 0.8 1.4 -0.6 -1.2 -0.8
Systolic blood pressure, automated reading 1.4 4.1 7.5 2.7 -1.6 -1.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 -0.1 -0.3 -0.3
Angina 0.4 0.5 0.7 0.4 -0.8 -0.8
Medication for hormone replacement therapy 0.1 0.1 0.2 0.1 0.5 0.4
Vitamin and mineral supplements 1.0 1.4 2.9 -1.7 -0.8 -0.8
Supplements: Zinc 0.2 0.2 0.3 0.5 0.5 0.4
Medication: Co-codamol 1.8 2.0 6.0 2.4 0.3 0.1
Medication: Metformin 0.2 0.2 0.4 0.4 -0.4 -0.7
Diabetes (father) 0.1 0.1 0.3 0.5 -0.2 -0.1
Diabetes (mother) 1.5 1.9 2.6 1.0 1.5 1.6
Severe depression (siblings) 0.3 0.4 0.4 0.6 0.6 0.6
Pack years adult smoking proportion 0.0 0.1 0.1 -0.3 -0.2 -0.1
Impedance of leg (right) 0.7 3.2 8.2 -2.9 0.5 1.0
Leg fat-free mass (left) 0.8 4.3 7.8 2.8 -1.6 -1.6
Trunk fat percentage 0.5 1.9 2.4 1.3 -1.6 -1.3
Hand grip strength (right) 0.4 1.1 1.3 1.1 -1.1 -0.8
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.5 -0.1 -0.2
Current tobacco smoking 0.4 0.6 1.1 0.7 1.0 0.6
Average weekly fortified wine intake 0.3 0.3 0.5 -0.1 -0.7 -0.7
Maternal smoking around birth 0.8 1.2 1.5 -1.0 1.1 1.2
Fed-up feelings 0.2 0.4 0.5 -0.6 -0.7 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 0.7 -0.4 -0.5
Relative age voice broke 0.2 0.3 0.8 0.9 0.4 0.0
Taking other prescription medications 2.5 3.9 9.3 3.1 -1.1 -1.2
Age when periods started (menarche) 0.9 2.2 3.3 -0.9 1.8 1.5
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 3.5 0.5 1.3 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.5 -0.4 -1.2 -1.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 0.6 -0.8 -0.7 -0.8
Qualifications: CSEs or equivalent 0.3 0.4 1.0 1.0 -0.3 -0.4
Serious illness, injury or assault to yourself 2.9 3.5 6.4 2.5 -1.4 -1.4
High blood pressure 4.9 13.6 19.8 4.5 -3.4 -3.1
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.4 0.6 -1.2 -1.0
Multivitamins +/- minerals 0.8 1.0 1.5 0.4 1.2 1.2
Stomach or abdominal pain in last month 0.8 1.0 1.5 -0.1 1.2 1.2
Supplements: Glucosamine 1.8 2.3 3.4 1.0 1.9 1.6
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.7 -0.1 0.6 0.8
Medication: Atenolol 0.5 0.7 1.5 1.2 -0.6 -0.4
Medication: Levothyroxine sodium 0.1 0.2 0.7 0.8 0.1 0.0
Sitting height 0.0 0.3 0.6 0.4 -0.8 -0.4
Chronic bronchitis/emphysema (father) 0.7 0.8 1.3 -1.1 0.6 0.9
High blood pressure (mother) 0.1 0.1 0.3 0.6 -0.2 -0.3
Body mass index (BMI) 1.0 4.4 7.6 2.8 -1.5 -1.8
Impedance of leg (left) 0.7 3.3 8.1 -2.8 0.6 1.2
Leg predicted mass (left) 0.9 4.7 8.5 2.9 -1.6 -1.7
Trunk fat mass 0.8 3.3 3.6 1.9 -1.9 -1.7
Waist circumference 1.1 4.0 4.9 1.5 -2.2 -2.2
Number of incorrect matches in round 0.2 0.3 0.3 0.5 -0.5 -0.6
Past tobacco smoking 0.2 0.4 0.9 -0.0 0.9 0.6
Alcohol usually taken with meals 1.8 2.8 3.5 -1.6 -1.9 -1.6
Nervous feelings 0.5 0.9 1.5 -1.2 0.9 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 6.3 2.5 -0.7 -0.9
Hearing difficulty/problems with background noise 5.9 9.5 11.8 -2.3 -3.4 -3.3
Hair/balding pattern: Pattern 2 0.8 1.0 1.3 0.7 -1.1 -1.2
Had menopause 0.6 0.7 0.9 0.5 -1.0 -1.0
Had other major operations 3.2 3.9 6.1 0.4 -2.5 -2.3
Forced vital capacity (FVC) 0.5 2.0 3.1 -1.8 0.9 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.5 -0.3 -0.7 -0.6
Ever unenthusiastic/disinterested for a whole week 6.2 7.6 8.0 2.6 -2.8 -2.8
Qualifications: None of the above 0.1 0.3 0.9 1.0 -0.2 0.1
Financial difficulties in last 2 years 0.5 0.7 1.3 1.2 0.7 0.5
Mouth/teeth dental problems 1.9 2.9 3.7 -1.4 1.9 1.8
Heart attack 0.5 0.6 1.0 -1.0 0.7 0.7
Allergy 0.6 1.3 1.5 -1.2 1.2 1.0
Pain all over the body in last month 1.5 1.6 4.5 2.1 0.4 0.4
Diabetes (self-reported) 1.6 2.5 5.7 2.4 -0.9 -1.0
Hayfever/allergic rhinitis (self-reported) 2.4 3.1 6.2 2.5 -1.3 -1.3
Medication: Ramipril 0.3 0.3 0.4 0.6 -0.5 -0.6
Medication: Simvastatin 0.8 1.1 3.0 1.7 -0.4 -0.5
Fluid intelligence score 0.5 1.1 3.3 -1.8 -0.2 -0.1
Illnesses of siblings 0.9 1.3 3.2 -1.8 0.6 0.6
Neuroticism score 0.8 1.6 2.3 -0.6 1.5 1.5
Weight 1.1 5.2 8.7 3.0 -1.9 -1.8
Impedance of arm (right) 0.3 1.4 2.4 -1.6 0.5 1.2
Arm fat percentage (right) 0.8 3.2 5.0 2.2 -1.5 -1.5
Trunk fat-free mass 0.9 5.3 10.9 3.3 -1.5 -1.7
Hip circumference 1.9 8.4 8.9 3.0 -2.9 -2.8
Time employed in main current job 0.6 0.7 1.1 0.4 -0.9 -1.1
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.5 0.1 0.2
Father’s age at death 1.9 2.6 3.2 -1.3 1.7 1.8
Worrier / anxious feelings 0.6 1.2 2.0 -0.4 1.4 1.2
Frequency of tiredness / lethargy in last 2 weeks 2.6 4.3 8.9 3.0 -1.3 -1.5
Falls in the last year 0.4 0.6 0.7 0.9 -0.7 -0.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.1 0.6 0.4
Number of live births 1.1 1.6 4.0 -2.0 0.6 0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.9 -1.7 0.7 1.0
Pulse rate 0.3 0.6 0.8 0.9 -0.7 -0.7
Happiness 0.1 0.1 0.2 0.4 0.0 -0.0
Noisy workplace 0.3 0.4 1.2 1.1 -0.1 0.1
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.4 -1.5 1.0 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 0.9 1.0 -0.6 -0.9
Mouth/teeth dental problems: Dentures 0.5 0.8 2.2 1.5 -0.5 -0.2
Asthma 0.3 0.5 0.8 0.2 -0.9 -0.9
Medication: Ibuprofen (e.g. Nurofen) 3.1 3.9 6.2 0.1 -2.3 -2.5
Medication: Cholesterol lowering 2.2 3.4 3.7 1.9 -1.9 -1.7
Depression (self-reported) 0.6 0.7 1.3 1.1 -0.6 -0.7
Medication: Lansoprazole 0.9 1.0 1.4 1.0 0.8 1.2
Prospective memory result 1.9 2.3 6.4 2.5 -0.4 -0.7
Lung cancer (father) 0.0 0.0 0.1 -0.3 0.0 0.1
Illnesses of mother 1.9 2.3 3.2 0.9 -1.7 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.8 -0.9 -0.0 0.2
Pulse wave Arterial Stiffness index 3.2 3.7 4.9 2.2 -1.8 -1.7
Impedance of arm (left) 0.3 1.5 4.2 -2.0 -0.1 0.5
Arm fat mass (right) 1.2 4.8 7.2 2.7 -1.9 -1.9
Trunk predicted mass 0.9 5.1 10.0 3.2 -1.6 -1.7
Standing height 0.1 0.7 1.4 0.7 -1.2 -0.5
Length of working week for main job 0.7 0.8 1.6 1.3 0.6 0.5
Exposure to tobacco smoke at home 0.9 1.0 1.6 -1.3 0.9 0.8
Breastfed as a baby 0.2 0.3 0.5 -0.4 -0.5 -0.7
Tense / ‘highly strung’ 0.4 0.6 1.3 1.1 0.4 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 0.2 -0.3 -0.1
Hair/balding pattern: Pattern 4 0.2 0.4 0.5 -0.5 0.7 0.5
Birth weight of first child 0.1 0.2 0.4 0.2 0.6 0.6
Peak expiratory flow (PEF) 0.5 1.2 3.3 -1.8 -0.3 -0.4
Pulse wave reflection index 1.1 1.4 2.2 0.9 -1.5 -1.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.0 1.0 -0.5 -0.6
Loud music exposure frequency 0.5 0.6 0.9 0.2 0.9 1.0
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 3.7 1.9 -0.5 -0.7
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.6 0.3 -1.1 -1.3
Blood clot in the leg (DVT) 0.7 0.9 2.0 1.4 -0.5 -0.7
Medication: Paracetamol 0.7 1.2 1.7 1.1 -1.3 -0.9
Headache pain in last month 0.4 0.7 1.0 -0.7 -1.0 -0.7
Medication for cholesterol, blood pressure or diabetes 4.3 7.1 9.1 -2.3 3.0 2.6
Glaucoma (self-reported) 0.2 0.2 0.7 0.8 0.0 -0.2
Gout (self-reported) 0.0 0.0 0.1 0.2 0.3 0.1
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.2 0.5 -0.1 -0.0
Medication: Amlodipine 3.1 4.3 5.5 2.0 -2.4 -1.9
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.4 0.5 0.4 0.6
Birth weight 0.3 0.7 1.7 1.3 0.5 0.5
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.2 -1.5 0.7 0.8
High blood pressure (siblings) 2.8 4.0 7.2 2.7 -1.5 -1.6
Forced vital capacity (FVC), Best measure 0.2 0.7 1.1 -1.0 0.5 0.9
Body fat percentage 0.5 1.9 2.3 1.3 -1.5 -1.3
Leg fat percentage (right) 0.5 1.8 2.1 1.1 -1.4 -1.4
Arm fat-free mass (right) 0.6 3.2 5.3 2.3 -1.4 -1.5
Exposure to tobacco smoke outside home 0.2 0.2 0.7 0.8 -0.2 -0.1
Comparative body size at age 10 0.2 0.4 0.8 -0.9 0.6 0.4
Number of full brothers 0.1 0.1 0.2 0.4 0.4 0.1
Worry too long after embarrassment 1.5 2.5 3.9 -0.5 1.8 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.5 1.6 -0.3 -0.4
Wheeze or whistling in the chest in last year 0.6 1.2 3.0 1.7 -0.5 -0.5
Number of children fathered 0.1 0.1 0.3 0.3 -0.5 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 0.1 -0.4 -0.3
Age at first live birth 0.3 0.4 1.2 1.1 0.3 0.0
Pulse wave peak to peak time 2.6 3.1 4.0 -2.0 1.7 1.6
Health satisfaction 5.7 7.4 8.7 2.9 -2.5 -2.6
Shortness of breath walking on level ground 2.6 3.1 5.1 2.3 -1.5 -1.4
Qualifications: College or University degree 0.7 2.2 5.3 -2.3 0.7 0.8
Eye problems/disorders: None of the above 1.0 1.1 1.9 -0.3 1.2 1.4
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.7 1.3 -0.3 -0.6
Emphysema/chronic bronchitis 2.8 3.2 8.6 2.9 -0.7 -0.7
Medication for pain relief, constipation, heartburn 1.3 2.2 2.6 -1.2 1.6 1.6
Neck or shoulder pain in last month 0.4 0.5 0.9 0.9 -0.6 -0.6
Medication: Blood pressure 4.4 7.8 11.8 3.4 -2.6 -2.2
Angina (self-reported) 0.8 1.0 1.4 0.5 -1.2 -1.2
Migraine (self-reported) 0.4 0.5 0.8 -0.1 -0.9 -0.7
Medication: Ibuprofen 3.0 3.6 5.2 0.9 -2.2 -2.3
Medication: Allopurinol 0.1 0.1 0.2 -0.1 -0.3 -0.4
Medication: Omeprazole 0.4 0.5 1.3 1.1 0.3 -0.0
Medication: Seretide 50 evohaler 0.3 0.4 0.9 1.0 0.4 0.3
Mean time to correctly identify matches 0.5 0.9 1.0 0.9 -1.0 -1.0
Heart disease (mother) 0.4 0.4 0.9 0.4 0.5 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.1 -1.5 -0.9 -0.9
Whole body fat mass 0.9 3.7 4.1 1.8 -2.0 -1.9
Leg fat mass (right) 0.8 3.3 3.8 1.6 -1.9 -1.9
Arm predicted mass (right) 0.6 3.0 5.4 2.3 -1.3 -1.4
Pulse rate, automated reading 0.6 1.9 2.2 1.5 1.4 1.2
Alcohol intake frequency. 2.2 5.2 5.6 2.3 -2.1 -2.4
Comparative height size at age 10 0.3 1.6 4.8 2.2 -0.2 0.1
Number of full sisters 0.2 0.2 0.5 0.7 0.3 0.3
Suffer from ‘nerves’ 1.0 1.6 2.0 -1.2 1.4 1.2
Overall health rating 2.9 6.2 15.2 3.9 -1.2 -1.5
Chest pain or discomfort 0.0 0.0 0.1 -0.2 -0.0 -0.1
Had major operations 1.6 1.8 3.1 0.6 -1.8 -1.4
Age at last live birth 0.6 0.8 1.0 -1.0 0.9 0.8
Family relationship satisfaction 0.7 0.9 1.4 0.4 -1.2 -1.1
Leg pain on walking 3.7 4.6 11.7 3.4 -1.0 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.3 -0.3 1.4 1.5
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.5 1.9 0.3 0.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 4.5 -2.1 -0.6 -0.4
Medication: Aspirin 4.7 6.2 8.9 1.3 -3.0 -2.8
Supplements: Vitamin C 0.5 0.6 1.3 1.2 -0.6 -0.5
Knee pain experienced in last month 3.5 5.5 14.7 3.8 -1.0 -0.9
Hypertension (Self-reported) 4.3 11.9 19.9 4.5 -3.0 -2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.0 -0.1 -0.1 0.1
Illnesses of father: Heart disease 0.3 0.3 0.4 0.6 -0.6 -0.6
Illnesses of siblings: Diabetes 0.1 0.2 0.2 -0.3 -0.4 -0.5
Smoking status: Previous 0.9 1.3 2.5 0.1 -1.6 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.0 -0.2 -1.4 -0.9
Whole body fat-free mass 0.9 5.0 9.5 3.1 -1.6 -1.7
Leg fat-free mass (right) 0.8 4.2 8.6 2.9 -1.4 -1.4
Arm fat percentage (left) 0.8 3.2 3.9 2.0 -1.7 -1.7
Average weekly red wine intake 0.7 1.0 1.5 -0.9 -1.2 -0.9
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.3 -0.8 1.1 1.2
Mood swings 2.2 4.1 6.2 -0.0 2.5 2.4
Loneliness, isolation 0.2 0.3 0.6 0.8 -0.4 -0.2
Long-standing illness, disability or infirmity 3.6 5.5 14.6 3.8 -1.0 -1.0
Ever had bowel cancer screening 0.2 0.2 0.2 0.5 -0.3 -0.5
Diabetes diagnosed by doctor 1.2 2.0 3.0 1.7 -1.1 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.9 0.5 -1.4 -0.9
Friendships satisfaction 1.6 2.0 3.0 -0.8 -1.6 -1.7
Qualifications: nursing, teaching 0.3 0.4 0.7 0.2 0.9 0.7
Commuting to job workplace: Walk 0.6 0.6 1.7 -1.3 -0.4 -0.3
Eye problems/disorders: Cataract 1.3 1.5 2.5 0.5 -1.3 -1.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.2 -1.1 0.6 0.1
Medication for cholesterol 0.7 1.1 3.2 -1.8 -0.1 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.7 -1.6 -0.2 -0.4
Back pain experienced in last month 1.2 1.8 4.4 2.1 0.7 0.6
Mineral and other dietary supplements 0.6 0.8 0.9 -0.9 -0.9 -0.8
Breast cancer (self-reported) 0.7 0.8 1.1 1.0 -1.0 -0.7
Asthma (self-reported) 0.4 0.7 1.1 0.1 -1.0 -1.1
Osteoporosis (self-reported) 0.6 0.7 1.1 -0.1 -1.0 -1.0
Osteoarthritis (self-reported) 0.1 0.1 0.2 -0.1 -0.5 -0.3
Medication: Aspirin 4.0 5.2 6.9 1.4 -2.6 -2.6
Medication: Gliclazide 1.6 1.8 2.7 -0.8 1.6 1.5
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.7 0.4 0.1
Smoking status: Current 0.6 1.0 1.9 0.5 1.4 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 -1.5 -0.6 -0.6
Whole body water mass 0.9 5.0 9.9 3.1 -1.5 -1.6
Leg predicted mass (right) 0.8 4.5 8.9 3.0 -1.5 -1.5
Arm fat mass (left) 1.1 4.5 7.3 2.7 -1.7 -1.8
Number of self-reported non-cancer illnesses 1.8 3.1 5.0 2.2 -1.6 -1.3
Average weekly champagne plus white wine intake 0.3 0.5 0.8 0.9 -0.3 -0.7
Miserableness 0.6 1.0 2.9 -1.7 0.1 0.4
Guilty feelings 0.4 0.7 0.9 0.7 0.9 0.8
Wears glasses or contact lenses 0.1 0.2 0.5 0.7 -0.2 -0.1
Ever taken oral contraceptive pill 0.4 0.4 0.6 -0.3 -0.7 -0.8
Hearing aid user 4.9 5.5 8.6 -0.4 2.9 2.8
Mother’s age at death 1.0 1.3 1.4 1.0 1.2 1.1
Financial situation satisfaction 0.3 0.4 0.6 0.8 0.7 0.3
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.2 0.5 -0.2 -0.5
Commuting to job workplace: Public transport 0.8 0.9 1.3 1.1 0.9 0.8
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.6 0.1 -0.2
Medication: Blood pressure 1.7 3.3 9.5 3.1 -0.3 -0.6
Pain type(s) experienced in last month: Hip pain 3.3 4.2 5.1 1.8 -2.1 -2.3
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.4 1.6 -1.1 -1.1
High cholesterol (Self-reported) 0.4 0.7 0.9 0.5 -1.0 -0.9
Medication: Bendroflumethiazide 7.8 11.9 15.4 2.3 -3.9 -3.9
Medication: Paracetamol 0.6 0.9 1.4 0.8 -1.2 -0.8
Medication: Lisinopril 0.3 0.3 1.0 1.0 -0.0 0.2
Medication: Atorvastatin 0.1 0.2 0.2 0.4 -0.4 -0.5
Illnesses of father: High blood pressure 0.7 0.8 2.0 1.4 0.4 0.5
Alcohol drinker status: Never 1.5 1.8 4.6 2.2 -0.6 -0.6
Ever smoked 0.0 0.0 0.1 -0.2 -0.1 -0.1
Basal metabolic rate 1.0 5.5 10.6 3.3 -1.7 -1.7
Leg fat percentage (left) 0.5 1.6 1.6 1.3 -1.3 -1.3
Arm fat-free mass (left) 0.8 4.2 9.1 3.0 -1.3 -1.3
Number of operations (self-reported) 2.2 3.3 4.9 1.3 -2.2 -1.8
Average weekly beer plus cider intake 4.4 6.4 9.8 -1.2 3.1 2.8
Irritability 0.1 0.1 0.3 0.5 -0.0 -0.1
Risk taking 0.9 1.4 3.1 -1.8 0.7 0.7
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.7 0.8 -0.0 0.0
Fractured/broken bones in last 5 years 3.5 4.6 6.8 1.6 -2.6 -2.1
Age started oral contraceptive pill 0.1 0.1 0.3 0.3 -0.2 -0.6
Diastolic blood pressure, automated reading 1.8 5.7 13.8 3.7 -1.3 -1.3
Ever depressed for a whole week 4.5 5.6 6.6 2.0 -2.6 -2.5
Unable to work because of sickness or disability 2.8 3.6 5.0 2.2 -1.7 -1.7
Commuting to job workplace: Cycle 0.4 0.4 0.6 -0.6 -0.8 -0.6
Myopia 0.6 0.8 1.0 -0.9 1.0 0.8
Vascular/heart problems diagnosed by doctor 4.8 13.2 17.0 -4.1 3.5 3.2
Cholesterol lowering medication 1.2 1.7 2.7 0.3 1.6 1.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.5 0.7 0.5 0.4
Pain experienced in last month 1.6 2.7 8.2 -2.9 -0.0 -0.0
Supplements: Calcium 1.3 1.5 3.9 -2.0 0.4 0.5
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 1.2 0.4 0.4
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.2 -1.5 0.9 0.9
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 3.2 1.8 -0.8 -0.9
Heart disease (siblings) 2.0 2.5 3.3 -1.1 1.7 1.8
Alcohol drinker status: Previous 1.0 1.1 1.8 -0.3 -1.4 -1.2
Pack years of smoking 0.1 0.1 0.3 -0.5 -0.3 -0.2
Impedance of whole body 0.6 3.1 7.5 -2.7 0.6 1.3
Leg fat mass (left) 0.8 3.0 3.2 1.7 -1.8 -1.8
Arm predicted mass (left) 0.8 3.8 9.3 3.0 -1.0 -1.1