Hub : Genes

CTC-487M23.5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.073 0.033 4.1e-03 0.026 NA 0.023 NA 0.029 4.5e-03 NA 6.8e-03 NA 2.9e-03
2 GTEx Skin Not Sun Exposed Suprapubic 0.095 0.046 8.0e-03 0.060 NA 0.025 NA 0.053 3.4e-04 NA 1.5e-02 NA 6.7e-04
3 GTEx Skin Sun Exposed Lower leg 0.165 0.047 4.5e-07 0.066 NA 0.046 NA 0.062 3.8e-06 NA 9.6e-05 NA 7.7e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.1 0.2 -0.3 -0.4
Bipolar Disorder or Schizophrenia 1.2 2.9 3.4 1.9 -1.6 -1.6
Depressed Affect (Nagel 2018) 1.6 3.3 3.5 -1.9 1.7 1.8
Depression (Nagel 2018) 0.2 0.3 0.5 0.7 -0.4 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.2 -0.4 0.7 1.1
Neuroticism (Nagel 2018) 0.9 2.1 3.2 1.8 -1.3 -1.2
Schizophrenia (2018) 1.9 3.9 4.8 2.2 -1.9 -1.8
Schizophrenia vs Biploar Disorder 1.7 2.3 2.9 1.4 -1.4 -1.7
Worry (Nagel 2018) 5.0 10.5 14.2 3.8 -3.0 -2.8
Alzheimer’s Disease (in mother) 0.7 0.8 1.2 0.3 -1.1 -1.1
Alzheimer’s Disease (in father) 2.3 2.5 6.1 2.5 -0.8 -0.9
Alzheimer’s Disease (including proxy) 2.3 3.4 4.3 2.1 -1.8 -1.6
Crohns Disease (2017) 0.5 1.1 2.0 -0.0 1.1 1.4
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 1.1 0.1 0.4
Ulcerative Colitis (UC) 1.0 1.9 3.1 1.8 -1.2 -1.0
Major Depression (MDD) 0.1 0.1 0.2 -0.2 0.1 0.5
Reaction Time 18.8 35.8 40.2 -6.3 5.7 5.9
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.1 0.1 -0.2 0.2
Breast Cancer 0.1 0.3 0.3 0.5 -0.6 -0.5
Ovarian Cancer 3.5 4.6 5.8 -2.2 1.8 2.4
Prostate Cancer 1.1 1.5 2.2 0.8 -1.5 -1.3
Age at First Birth 0.6 0.9 0.9 0.9 -0.9 -1.0
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.8 0.3 -0.1
Body Mass Index (BMI) (2010) 1.8 2.5 3.8 -2.0 1.5 1.2
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.3 -0.0 -0.4
Crohns Disease (2012) 0.1 0.2 0.4 0.2 0.5 0.6
Mean Putamen Volume 1.7 2.0 2.9 1.0 -1.7 -1.4
Fasting Glucose 0.3 0.3 0.7 -0.1 0.8 0.6
HbA1C 0.7 0.8 1.5 -1.2 0.6 0.7
HDL Cholesterol 0.0 0.1 0.1 0.2 -0.2 -0.3
LDL Cholesterol 0.5 0.8 1.3 -0.4 1.1 1.0
Lupus 1.0 1.5 1.9 1.4 -1.3 -0.9
Neuroticism (2016) 0.2 0.3 0.6 -0.2 -0.8 -0.6
Primary Biliary Cirrhosis 0.6 0.8 1.4 0.5 -1.2 -0.9
Rheumatoid Arthritis 0.7 0.9 1.9 -1.4 0.9 0.3
Schizophrenia (2014) 0.9 2.0 3.1 1.8 -1.1 -1.3
Triglycerides 0.7 1.2 2.2 -1.5 0.8 0.9
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.4 0.3 0.4
Ulcerative Colitis 1.9 2.8 5.4 2.3 -1.3 -1.1
Blood Eosinophil Count 0.3 2.4 3.8 -2.0 0.8 1.6
Blood Platelet Count 0.0 0.0 0.1 -0.3 0.1 -0.1
Blood Red Count 0.0 0.2 0.7 0.8 -0.1 -0.2
Blood White Count 0.3 2.0 2.8 -1.7 1.1 1.4
Heel T-Score 5.6 44.4 50.8 -7.1 6.4 6.4
BMI 3.7 21.6 27.1 -3.9 4.7 5.2
Height 3.7 71.9 97.1 -9.9 8.0 7.4
Waist Hip Ratio (WHR) 0.4 1.8 2.2 -1.4 1.5 1.1
Systolic Blood Pressure 0.3 1.4 2.3 -0.8 1.5 1.1
Smoking Status 2.8 6.6 8.9 -3.0 2.3 2.3
Allergy or Eczema 0.1 0.2 0.4 -0.3 0.4 0.6
Cardiovascular Disease 2.4 7.8 9.1 -2.5 3.0 2.8
Hypothyroidism (self reported) 1.7 3.9 5.8 -2.4 1.4 2.0
Respiratory disease 4.0 9.0 13.7 -3.7 2.5 2.6
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.2 -1.1 0.9 0.9
Lung FEV1/FVC ratio 1.6 7.9 13.2 3.6 -2.3 -2.3
Lung FVC 0.2 0.8 1.5 1.2 -0.9 -0.5
Neuroticism 0.9 2.2 3.3 1.8 -1.5 -1.0
Chronotype (morning person) 0.1 0.3 0.5 0.3 0.7 0.5
Hair Pigment 0.1 1.8 3.2 -1.8 1.4 0.5
Tanning 0.3 3.3 3.4 -1.8 1.8 1.8
Hand grip strength (left) 0.1 0.3 0.3 0.5 -0.5 -0.6
Number of treatments/medications taken 2.9 5.2 6.8 -2.0 2.2 2.6
Average weekly spirits intake 0.5 0.6 0.9 -1.0 0.8 0.5
Sensitivity / hurt feelings 2.6 4.5 5.9 2.4 -1.9 -1.9
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.1 0.3 -0.2 -0.1
Hearing difficulty/problems: Yes 0.3 0.4 0.6 -0.5 0.7 0.7
Relative age of first facial hair 0.1 0.1 0.4 -0.6 0.2 -0.1
Other serious medical condition/disability diagnosed by doctor 3.7 4.8 6.2 -1.5 2.5 2.4
Ever used hormone-replacement therapy (HRT) 2.0 2.5 3.8 -0.9 1.9 1.7
Ever had hysterectomy (womb removed) 5.0 5.7 7.7 -2.8 2.4 1.9
Systolic blood pressure, automated reading 1.4 4.1 5.6 -1.6 2.4 2.1
Eye problems/disorders: Diabetes related eye disease 4.2 4.6 6.3 2.0 -1.9 -2.5
Angina 0.2 0.2 0.4 0.6 -0.1 -0.5
Medication for hormone replacement therapy 0.4 0.4 0.6 0.8 0.6 0.6
Vitamin and mineral supplements 2.3 3.2 4.2 1.6 -1.6 -2.1
Supplements: Zinc 0.8 0.9 1.3 -0.5 1.1 1.1
Medication: Co-codamol 2.6 3.0 3.6 -1.9 1.7 1.5
Medication: Metformin 0.4 0.5 0.7 -0.5 0.8 0.8
Diabetes (father) 4.1 5.1 6.9 -2.6 2.0 2.1
Diabetes (mother) 1.0 1.3 1.7 -1.0 1.3 1.1
Severe depression (siblings) 2.0 2.2 3.2 -0.8 1.8 1.7
Pack years adult smoking proportion 0.3 0.4 1.1 -1.1 0.0 0.2
Impedance of leg (right) 0.9 4.2 6.9 1.3 -2.0 -2.6
Leg fat-free mass (left) 4.1 21.6 26.2 -4.3 4.5 5.1
Trunk fat percentage 1.0 3.9 4.1 -2.0 1.9 2.0
Hand grip strength (right) 0.0 0.1 0.1 -0.3 0.4 0.2
Townsend deprivation index at recruitment 1.1 1.6 2.1 -1.4 1.5 0.9
Current tobacco smoking 1.1 1.9 2.7 -1.6 1.5 0.8
Average weekly fortified wine intake 0.3 0.4 0.6 -0.5 0.6 0.8
Maternal smoking around birth 0.7 1.1 1.4 -1.0 1.2 0.9
Fed-up feelings 1.5 2.6 3.5 -1.4 1.9 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 -0.0 0.2 0.3
Relative age voice broke 0.2 0.4 0.6 -0.5 -0.7 -0.5
Taking other prescription medications 0.7 1.1 1.4 -1.2 0.8 1.1
Age when periods started (menarche) 0.5 1.2 2.2 -1.5 1.0 0.6
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.1 -1.0 1.5 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 5.2 -2.3 1.7 1.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 -0.4 -0.0 -0.7
Qualifications: CSEs or equivalent 0.2 0.3 0.6 0.8 -0.4 -0.0
Serious illness, injury or assault to yourself 0.2 0.3 0.8 -0.3 0.9 0.3
High blood pressure 1.8 5.1 6.3 -1.6 2.5 2.5
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.3 0.0 0.2 0.6
Multivitamins +/- minerals 2.5 3.2 4.1 -1.8 1.6 2.0
Stomach or abdominal pain in last month 0.4 0.5 0.8 -0.9 0.1 0.8
Supplements: Glucosamine 3.0 3.9 5.5 -1.6 1.9 2.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 0.7 -0.0 0.7 0.9
Medication: Atenolol 0.1 0.2 0.4 -0.0 0.6 0.3
Medication: Levothyroxine sodium 0.9 1.5 1.7 -1.2 1.2 1.3
Sitting height 3.9 27.5 35.4 -6.0 4.7 5.0
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 -0.1 -0.3 -0.7
High blood pressure (mother) 1.2 1.7 2.3 -0.8 1.4 1.5
Body mass index (BMI) 1.6 7.0 9.4 -2.2 2.6 3.1
Impedance of leg (left) 1.2 6.0 10.4 1.2 -2.4 -3.2
Leg predicted mass (left) 4.1 21.5 26.4 -4.3 4.5 5.1
Trunk fat mass 2.3 10.0 10.6 -3.1 3.1 3.3
Waist circumference 2.9 10.7 13.0 -3.1 3.1 3.6
Number of incorrect matches in round 1.9 3.2 3.7 1.6 -1.8 -1.9
Past tobacco smoking 0.5 1.0 1.4 1.2 -0.7 -1.0
Alcohol usually taken with meals 0.4 0.6 0.9 -0.9 0.7 0.7
Nervous feelings 4.5 8.4 9.4 3.0 -3.1 -2.6
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.1 -0.8 0.8 1.1
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.5 -0.0 0.3
Hair/balding pattern: Pattern 2 5.3 6.8 9.9 -3.1 2.2 2.4
Had menopause 0.3 0.4 1.1 1.1 -0.0 -0.2
Had other major operations 1.4 1.7 3.0 -0.8 1.7 1.2
Forced vital capacity (FVC) 0.1 0.2 0.3 -0.5 0.4 0.5
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.7 4.1 -1.8 1.9 2.0
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 -0.1 -0.2 0.1
Qualifications: None of the above 0.9 1.9 3.3 -1.8 1.3 0.8
Financial difficulties in last 2 years 0.4 0.6 1.0 -1.0 0.4 0.8
Mouth/teeth dental problems 0.0 0.0 0.1 0.3 0.1 -0.1
Heart attack 0.3 0.4 0.9 1.0 -0.3 -0.4
Allergy 0.8 1.8 2.6 1.1 -1.2 -1.6
Pain all over the body in last month 1.3 1.4 2.5 -0.7 1.1 1.6
Diabetes (self-reported) 0.1 0.1 0.3 0.3 0.5 0.3
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.3 0.1 0.1 0.5
Medication: Ramipril 0.0 0.0 0.0 -0.2 0.1 0.0
Medication: Simvastatin 0.1 0.1 0.3 0.5 -0.3 -0.1
Fluid intelligence score 0.5 1.1 1.6 1.0 -1.3 -0.8
Illnesses of siblings 2.5 3.5 4.4 2.0 -2.1 -1.5
Neuroticism score 1.0 2.1 2.9 1.7 -1.5 -1.0
Weight 3.8 18.9 20.4 -4.5 4.1 4.5
Impedance of arm (right) 3.0 14.0 15.5 3.5 -3.8 -3.9
Arm fat percentage (right) 1.1 4.2 6.1 -1.6 2.0 2.5
Trunk fat-free mass 5.5 31.3 33.1 -5.6 5.5 5.8
Hip circumference 1.9 8.2 10.9 -2.7 2.5 3.3
Time employed in main current job 0.8 0.9 1.5 1.2 -0.7 -0.9
Alcohol intake versus 10 years previously 2.4 3.6 4.0 -1.7 1.9 2.0
Father’s age at death 0.4 0.6 1.0 0.6 -1.0 -0.7
Worrier / anxious feelings 4.5 8.5 10.2 3.2 -3.0 -2.5
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.7 4.3 -2.1 1.3 1.4
Falls in the last year 0.8 1.0 1.4 -1.2 1.0 0.8
Hair/balding pattern: Pattern 3 0.8 1.3 1.8 0.9 -1.0 -1.3
Number of live births 0.4 0.5 0.8 -0.2 0.9 0.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.0 1.4 -0.9 -0.6
Pulse rate 3.1 5.3 6.1 -2.3 2.5 2.1
Happiness 0.4 0.5 0.8 0.7 -0.5 -0.9
Noisy workplace 1.4 1.7 1.8 -1.3 1.3 1.3
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.1 0.2 -0.1 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.4 0.9 -1.2 -1.1
Mouth/teeth dental problems: Dentures 0.6 1.0 1.3 -1.0 0.8 1.2
Asthma 1.0 2.0 3.0 -1.7 1.0 1.4
Medication: Ibuprofen (e.g. Nurofen) 3.9 4.9 5.6 -2.4 2.0 2.3
Medication: Cholesterol lowering 0.2 0.2 0.3 -0.5 0.5 0.5
Depression (self-reported) 0.3 0.4 0.6 -0.6 0.2 0.8
Medication: Lansoprazole 0.2 0.3 0.3 -0.5 0.5 0.5
Prospective memory result 0.9 1.1 1.5 -0.9 1.2 1.0
Lung cancer (father) 0.0 0.0 0.1 0.1 0.1 -0.3
Illnesses of mother 2.6 3.3 3.8 1.8 -1.6 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.7 1.3 -0.7 -0.5
Pulse wave Arterial Stiffness index 9.5 11.1 14.1 -2.8 3.8 3.4
Impedance of arm (left) 2.9 13.5 16.2 3.3 -3.7 -4.0
Arm fat mass (right) 3.2 13.1 16.1 -3.2 3.6 4.0
Trunk predicted mass 5.5 31.2 32.9 -5.5 5.5 5.7
Standing height 2.0 19.6 27.7 -5.3 4.0 3.9
Length of working week for main job 0.6 0.7 1.5 -0.5 1.2 0.5
Exposure to tobacco smoke at home 1.6 1.8 2.0 -1.2 1.3 1.4
Breastfed as a baby 4.1 5.0 6.5 -1.9 2.5 2.2
Tense / ‘highly strung’ 0.0 0.0 0.1 0.2 -0.0 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 1.7 -1.2 1.0 1.3
Hair/balding pattern: Pattern 4 0.6 1.4 2.3 -0.3 1.3 1.5
Birth weight of first child 0.1 0.2 0.4 -0.6 0.6 0.2
Peak expiratory flow (PEF) 4.1 9.6 12.7 3.6 -3.0 -2.7
Pulse wave reflection index 0.1 0.2 0.2 0.4 0.3 0.5
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.8 0.1 0.8 0.9
Loud music exposure frequency 0.0 0.0 0.1 -0.0 -0.1 -0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.1 -0.5 -0.1
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 0.1 -0.2 0.1
Blood clot in the leg (DVT) 0.8 1.0 1.6 -0.7 1.3 0.9
Medication: Paracetamol 0.3 0.5 1.4 -0.0 0.5 1.2
Headache pain in last month 0.7 1.1 2.0 -0.5 1.1 1.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 0.9 0.4 -1.0 -0.9
Glaucoma (self-reported) 2.0 2.4 2.8 1.7 -1.5 -1.4
Gout (self-reported) 1.1 1.6 3.6 -1.9 0.9 0.6
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.5 -1.2 0.6 1.1
Medication: Amlodipine 1.6 2.2 2.8 -1.4 1.7 1.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 -0.5 -0.9 -0.6
Birth weight 1.0 2.3 3.9 -2.0 1.3 1.1
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.0 -0.1 0.2 0.0
High blood pressure (siblings) 1.3 1.9 2.7 -1.5 1.7 0.9
Forced vital capacity (FVC), Best measure 0.0 0.1 0.3 -0.0 0.3 0.6
Body fat percentage 1.0 3.9 4.4 -1.9 1.9 2.1
Leg fat percentage (right) 1.5 5.6 7.1 -2.0 2.4 2.7
Arm fat-free mass (right) 5.9 30.1 31.2 -5.5 5.4 5.6
Exposure to tobacco smoke outside home 0.4 0.5 0.8 0.9 -0.7 -0.4
Comparative body size at age 10 0.2 0.6 1.7 1.3 -0.1 0.3
Number of full brothers 0.8 1.0 1.6 0.9 -0.8 -1.3
Worry too long after embarrassment 2.6 4.4 8.7 2.9 -1.8 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.8 6.4 -0.9 2.5 2.1
Wheeze or whistling in the chest in last year 0.5 0.9 1.4 -1.1 0.5 1.2
Number of children fathered 0.3 0.3 0.4 -0.4 -0.6 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.3 1.1 0.1 0.1
Age at first live birth 0.2 0.3 0.6 0.8 -0.4 0.0
Pulse wave peak to peak time 7.7 9.1 12.0 2.5 -3.5 -3.0
Health satisfaction 0.8 1.1 1.5 -1.2 0.8 1.0
Shortness of breath walking on level ground 0.5 0.7 1.3 -1.1 0.3 0.7
Qualifications: College or University degree 0.1 0.4 0.8 0.9 0.1 0.6
Eye problems/disorders: None of the above 0.8 0.9 2.2 -1.5 0.5 0.5
Mouth/teeth dental problems: Loose teeth 1.6 1.9 2.8 -1.7 1.3 1.1
Emphysema/chronic bronchitis 1.4 1.6 2.6 -1.6 1.0 1.1
Medication for pain relief, constipation, heartburn 4.0 6.8 8.7 2.4 -2.4 -2.9
Neck or shoulder pain in last month 2.9 4.2 5.2 -2.3 1.8 2.0
Medication: Blood pressure 0.3 0.5 0.8 0.0 0.9 0.7
Angina (self-reported) 0.1 0.2 0.4 0.6 -0.1 -0.4
Migraine (self-reported) 0.2 0.2 0.3 0.6 -0.4 -0.3
Medication: Ibuprofen 3.3 4.0 4.5 -2.0 1.9 2.1
Medication: Allopurinol 0.9 1.3 2.4 0.3 -1.1 -1.6
Medication: Omeprazole 0.1 0.1 0.2 0.3 0.3 0.4
Medication: Seretide 50 evohaler 1.1 1.3 3.8 -1.9 0.2 0.2
Mean time to correctly identify matches 18.4 35.0 36.6 -6.0 5.9 5.8
Heart disease (mother) 1.0 1.3 1.6 1.3 -1.2 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 0.9 0.7 -1.0 -0.8
Whole body fat mass 2.6 11.0 12.4 -3.1 3.3 3.5
Leg fat mass (right) 2.7 10.6 12.9 -2.9 3.2 3.6
Arm predicted mass (right) 5.7 29.3 29.9 -5.5 5.3 5.5
Pulse rate, automated reading 0.8 2.7 3.5 -1.9 1.6 1.3
Alcohol intake frequency. 0.0 0.1 0.2 -0.3 0.2 0.4
Comparative height size at age 10 2.8 15.3 17.6 -4.2 3.9 3.6
Number of full sisters 0.5 0.6 1.5 -1.2 0.5 -0.2
Suffer from ‘nerves’ 2.0 3.2 6.0 2.5 -1.2 -1.4
Overall health rating 0.5 1.0 1.2 -1.1 1.1 0.8
Chest pain or discomfort 6.1 8.8 13.8 -3.7 2.5 2.5
Had major operations 0.0 0.0 0.1 -0.1 -0.1 -0.4
Age at last live birth 1.4 2.0 4.3 2.1 -1.1 -0.7
Family relationship satisfaction 0.1 0.1 0.2 0.4 -0.3 0.2
Leg pain on walking 1.6 2.0 3.2 -1.8 1.3 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.2 1.1 -0.7 -0.9
Commuting to job workplace: Car/motor vehicle 1.4 1.6 2.8 -1.7 1.1 0.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.3 0.6 -0.5 -0.1
Medication: Aspirin 0.7 0.9 1.2 -0.9 0.9 1.1
Supplements: Vitamin C 0.4 0.5 0.8 -0.1 0.8 0.9
Knee pain experienced in last month 4.9 7.7 8.7 -2.7 2.9 2.6
Hypertension (Self-reported) 2.0 5.7 7.1 -1.7 2.7 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.0 0.4 -1.0 -0.8
Illnesses of father: Heart disease 0.2 0.2 0.3 -0.5 0.3 0.6
Illnesses of siblings: Diabetes 0.1 0.1 0.1 -0.0 -0.2 -0.4
Smoking status: Previous 0.1 0.1 0.2 -0.4 -0.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.0 -1.4 -0.3 0.5
Whole body fat-free mass 5.3 30.0 33.4 -5.3 5.3 5.8
Leg fat-free mass (right) 3.6 19.4 22.9 -4.2 4.2 4.8
Arm fat percentage (left) 0.8 3.1 4.5 -1.4 1.7 2.1
Average weekly red wine intake 0.7 1.0 1.3 -0.8 1.1 1.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.8 -1.4 1.0 0.7
Mood swings 1.9 3.4 6.0 -2.4 1.4 1.5
Loneliness, isolation 0.1 0.1 0.3 -0.3 -0.5 -0.3
Long-standing illness, disability or infirmity 0.9 1.4 1.8 -1.3 1.4 0.9
Ever had bowel cancer screening 2.9 3.4 4.7 -2.2 1.7 1.6
Diabetes diagnosed by doctor 0.3 0.4 0.8 -0.2 0.9 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.0 -0.3 1.4 1.4
Friendships satisfaction 0.1 0.1 0.3 0.1 0.3 0.5
Qualifications: nursing, teaching 0.4 0.6 1.0 -0.3 0.8 1.0
Commuting to job workplace: Walk 0.7 0.7 1.4 1.2 -0.8 -0.3
Eye problems/disorders: Cataract 0.1 0.1 0.2 -0.1 -0.5 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.2 0.6 -1.4 -2.0
Medication for cholesterol 1.3 1.9 2.6 1.0 -1.6 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 1.0 -0.2 -0.4
Back pain experienced in last month 0.2 0.3 0.3 -0.6 0.3 0.6
Mineral and other dietary supplements 0.4 0.5 0.8 0.3 -0.8 -0.9
Breast cancer (self-reported) 0.0 0.0 0.1 -0.2 -0.0 0.0
Asthma (self-reported) 1.4 2.7 4.2 -2.0 1.3 1.5
Osteoporosis (self-reported) 5.3 6.5 8.2 2.9 -2.3 -2.5
Osteoarthritis (self-reported) 2.7 3.4 4.5 -1.6 2.1 1.8
Medication: Aspirin 0.4 0.5 0.6 -0.5 0.7 0.8
Medication: Gliclazide 2.3 2.7 5.2 -2.3 1.4 1.0
Illnesses of father: None of the above (group 1) 1.9 2.3 3.0 1.7 -1.3 -1.5
Smoking status: Current 0.9 1.4 2.5 -1.6 1.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.2 6.8 10.8 3.3 -2.4 -1.9
Whole body water mass 5.3 30.4 33.3 -5.4 5.3 5.8
Leg predicted mass (right) 3.7 19.7 23.1 -4.3 4.2 4.8
Arm fat mass (left) 2.6 10.8 13.0 -3.0 3.3 3.6
Number of self-reported non-cancer illnesses 2.2 3.8 4.5 -1.7 2.0 2.1
Average weekly champagne plus white wine intake 1.2 1.7 2.8 -1.7 1.1 0.9
Miserableness 1.6 2.8 4.1 -2.0 1.3 1.6
Guilty feelings 8.8 13.3 18.8 4.3 -3.2 -3.3
Wears glasses or contact lenses 0.6 0.7 1.2 -0.5 0.8 1.1
Ever taken oral contraceptive pill 3.3 3.7 5.6 -2.4 1.5 1.8
Hearing aid user 4.4 4.9 5.8 -2.4 1.9 2.3
Mother’s age at death 0.0 0.1 0.1 -0.4 0.1 0.2
Financial situation satisfaction 1.2 1.5 2.1 -0.8 1.3 1.4
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.4 -0.2 1.4 1.5
Commuting to job workplace: Public transport 0.1 0.1 0.4 0.6 0.1 0.0
Eye problems/disorders: Glaucoma 1.8 2.1 3.0 1.7 -1.4 -1.2
Medication: Blood pressure 2.4 4.5 5.3 -1.9 2.3 2.2
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 -0.1 0.0 0.2
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 0.0 0.2 0.2
High cholesterol (Self-reported) 0.2 0.3 0.5 -0.3 0.7 0.5
Medication: Bendroflumethiazide 3.5 5.3 7.8 -1.4 2.8 2.5
Medication: Paracetamol 0.1 0.1 0.3 0.2 0.0 0.5
Medication: Lisinopril 1.4 1.8 2.5 -0.8 1.5 1.6
Medication: Atorvastatin 1.4 1.7 2.5 -1.6 1.3 1.0
Illnesses of father: High blood pressure 2.8 3.5 3.9 -1.7 1.9 2.0
Alcohol drinker status: Never 0.0 0.0 0.0 -0.1 -0.1 0.2
Ever smoked 1.7 3.1 3.9 -2.0 1.6 1.6
Basal metabolic rate 5.4 29.7 32.7 -5.3 5.3 5.7
Leg fat percentage (left) 1.2 4.3 5.0 -1.9 2.1 2.2
Arm fat-free mass (left) 5.9 29.9 30.9 -5.5 5.3 5.6
Number of operations (self-reported) 4.0 5.9 7.2 -2.4 2.7 2.2
Average weekly beer plus cider intake 1.1 1.6 2.3 0.7 -1.5 -1.5
Irritability 0.9 1.6 3.0 -1.7 0.7 1.1
Risk taking 3.2 4.7 5.1 -2.3 2.2 2.1
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 -0.5 0.3 0.7
Fractured/broken bones in last 5 years 2.5 3.2 3.6 1.8 -1.9 -1.6
Age started oral contraceptive pill 3.1 3.8 4.4 2.1 -1.7 -2.0
Diastolic blood pressure, automated reading 2.4 7.5 8.7 -2.4 2.9 3.0
Ever depressed for a whole week 0.1 0.1 0.2 -0.1 -0.3 -0.4
Unable to work because of sickness or disability 0.4 0.6 0.7 0.7 -0.8 -0.8
Commuting to job workplace: Cycle 0.1 0.2 0.3 0.1 0.6 0.4
Myopia 0.0 0.0 0.1 0.3 -0.1 -0.1
Vascular/heart problems diagnosed by doctor 1.7 4.7 5.8 1.8 -2.3 -2.4
Cholesterol lowering medication 0.2 0.3 0.5 -0.7 0.4 0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.6 0.0 0.7 0.8
Pain experienced in last month 2.9 4.9 6.7 1.5 -2.4 -2.6
Supplements: Calcium 0.8 0.8 2.3 1.5 -0.4 -0.3
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.2 -0.8 0.2
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.5 0.7 -0.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 2.6 -1.0 1.6 1.1
Heart disease (siblings) 0.2 0.3 0.5 -0.7 0.6 -0.0
Alcohol drinker status: Previous 0.6 0.6 0.8 -0.9 0.6 0.9
Pack years of smoking 0.4 0.6 1.7 -1.3 0.1 0.2
Impedance of whole body 2.2 11.3 15.3 2.6 -3.4 -3.9
Leg fat mass (left) 2.6 10.1 11.6 -3.0 3.1 3.4
Arm predicted mass (left) 5.8 29.4 30.1 -5.5 5.3 5.5