Hub : Genes

CTC-492K19.4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Left Ventricle 0.252 0.0799 0.00160 0.084 NA 0.125 NA 0.077 0.00003 NA 3.6e-07 NA 6.8e-05
2 GTEx Testis 0.297 0.0820 0.00014 0.030 NA 0.035 NA 0.018 0.01700 NA 1.1e-02 NA 5.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 0.9 0.8 -0.9
Bipolar Disorder or Schizophrenia 0.8 1.9 3.5 0.5 -1.9
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 -0.4 -0.7
Depression (Nagel 2018) 0.2 0.3 0.3 -0.6 -0.5
Intelligence (Savage-Jansen 2018) 0.7 2.1 2.9 -1.7 -1.1
Neuroticism (Nagel 2018) 0.4 0.9 1.0 -1.0 -1.0
Schizophrenia (2018) 0.7 1.4 2.9 -0.1 -1.7
Schizophrenia vs Biploar Disorder 0.7 0.9 1.7 -1.3 -0.4
Worry (Nagel 2018) 0.2 0.5 0.8 -0.5 -0.9
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 -0.1 0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.5 0.7 -0.1
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 -0.1 -0.0
Crohns Disease (2017) 0.4 0.8 1.4 1.2 0.4
Irritable Bowel Disease (IBD) 0.6 1.5 2.2 1.5 -0.8
Ulcerative Colitis (UC) 1.0 1.9 2.5 1.1 -1.6
Major Depression (MDD) 0.7 0.8 1.2 0.7 -1.1
Reaction Time 0.3 0.6 0.6 0.7 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.1 -1.1 -0.7
Breast Cancer 0.0 0.1 0.1 -0.3 -0.1
Ovarian Cancer 0.4 0.5 0.5 -0.7 -0.7
Prostate Cancer 0.0 0.0 0.1 0.2 -0.1
Age at First Birth 0.3 0.5 0.9 0.3 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.3 -0.4 1.2
Coronary Artery Disease (CAD) 0.8 1.0 1.1 0.9 1.1
Crohns Disease (2012) 0.4 0.7 1.1 0.5 1.0
Mean Putamen Volume 2.2 2.6 3.4 1.8 -1.3
Fasting Glucose 0.2 0.2 0.5 0.7 -0.0
HbA1C 0.0 0.0 0.0 0.1 0.1
HDL Cholesterol 0.6 1.0 1.2 -0.9 1.1
LDL Cholesterol 0.4 0.6 0.6 -0.7 0.8
Lupus 0.9 1.4 1.8 -1.0 -1.4
Neuroticism (2016) 0.6 0.9 1.7 -0.3 1.3
Primary Biliary Cirrhosis 0.4 0.6 0.7 -0.8 -0.7
Rheumatoid Arthritis 0.4 0.6 0.7 0.7 -0.8
Schizophrenia (2014) 0.4 0.8 1.1 -0.8 -1.0
Triglycerides 0.1 0.1 0.2 0.3 0.5
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.6 -0.5 1.3
Ulcerative Colitis 0.1 0.1 0.1 0.3 -0.4
Blood Eosinophil Count 0.3 2.4 4.7 -2.2 0.3
Blood Platelet Count 0.1 1.6 3.0 -0.4 1.7
Blood Red Count 0.1 1.1 2.1 -0.3 1.5
Blood White Count 0.6 4.3 8.4 -2.9 -0.5
Heel T-Score 0.6 4.5 8.2 -0.9 -2.9
BMI 0.1 0.5 0.7 -0.9 0.4
Height 1.3 24.9 49.7 -0.1 -7.0
Waist Hip Ratio (WHR) 2.0 8.9 17.1 0.9 4.1
Systolic Blood Pressure 0.6 2.8 5.5 -2.4 0.3
Smoking Status 0.5 1.3 2.4 1.6 -0.3
Allergy or Eczema 0.1 0.1 0.2 0.5 0.2
Cardiovascular Disease 2.2 7.1 13.4 -3.7 1.0
Hypothyroidism (self reported) 1.8 4.1 6.2 1.4 2.5
Respiratory disease 0.1 0.2 0.3 -0.4 -0.5
Type 2 Diabetes (T2D) (2018) 1.6 3.0 4.6 -1.2 2.1
Lung FEV1/FVC ratio 2.3 11.5 22.4 4.7 0.8
Lung FVC 0.3 1.3 1.5 1.1 -1.2
Neuroticism 0.3 0.8 1.1 -0.7 -1.1
Chronotype (morning person) 2.0 4.6 9.1 -3.0 -0.3
Hair Pigment 0.1 3.9 4.9 1.7 2.2
Tanning 0.0 0.2 0.3 0.5 0.4
Hand grip strength (left) 0.2 0.6 1.2 0.2 -1.1
Number of treatments/medications taken 0.8 1.4 1.5 -1.2 -1.1
Average weekly spirits intake 0.6 0.8 1.5 -0.1 -1.2
Sensitivity / hurt feelings 0.0 0.1 0.2 0.4 0.1
Frequency of depressed mood in last 2 weeks 1.1 1.5 1.7 -1.1 -1.3
Hearing difficulty/problems: Yes 2.7 4.2 4.3 2.1 2.0
Relative age of first facial hair 0.4 0.8 1.2 0.7 -1.1
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 2.8 1.7 0.6
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.7 1.7 -0.3
Ever had hysterectomy (womb removed) 1.6 1.8 3.5 1.9 -0.1
Systolic blood pressure, automated reading 0.6 1.8 2.2 -1.5 -1.2
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 2.6 0.8 1.6
Angina 0.4 0.5 1.1 -1.0 0.2
Medication for hormone replacement therapy 5.7 6.3 11.9 3.4 0.9
Vitamin and mineral supplements 1.1 1.5 2.1 1.4 -1.0
Supplements: Zinc 1.2 1.3 1.8 -0.9 -1.3
Medication: Co-codamol 2.4 2.8 5.5 0.2 2.4
Medication: Metformin 1.4 2.0 3.1 -0.9 1.8
Diabetes (father) 2.0 2.5 3.8 -1.1 1.9
Diabetes (mother) 0.0 0.0 0.1 -0.3 0.1
Severe depression (siblings) 0.8 0.9 0.9 1.0 -0.9
Pack years adult smoking proportion 6.0 9.2 14.4 -2.0 3.8
Impedance of leg (right) 0.5 2.6 4.2 2.1 1.0
Leg fat-free mass (left) 0.7 3.7 7.3 -0.3 -2.7
Trunk fat percentage 0.7 2.8 3.0 1.6 -1.7
Hand grip strength (right) 0.1 0.2 0.4 0.3 -0.6
Townsend deprivation index at recruitment 2.6 3.7 7.2 -0.4 2.7
Current tobacco smoking 1.2 2.0 3.0 1.7 -1.0
Average weekly fortified wine intake 2.5 2.9 3.0 1.7 -1.7
Maternal smoking around birth 1.7 2.5 4.8 0.4 -2.2
Fed-up feelings 0.1 0.1 0.2 -0.5 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.1 -0.0 1.5
Relative age voice broke 0.8 1.2 2.5 -0.1 -1.6
Taking other prescription medications 0.1 0.2 0.3 -0.5 -0.2
Age when periods started (menarche) 0.1 0.3 0.3 -0.6 0.5
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 1.3 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.7 1.3 -0.2
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.0 -0.3 1.0
Qualifications: CSEs or equivalent 0.2 0.3 0.3 -0.6 0.5
Serious illness, injury or assault to yourself 0.0 0.0 0.1 -0.0 0.3
High blood pressure 0.7 1.9 3.5 -1.9 -0.5
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 0.2 0.3
Multivitamins +/- minerals 1.8 2.3 2.6 -1.4 1.6
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.2 0.5
Supplements: Glucosamine 1.9 2.5 4.1 -2.0 -1.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 1.4 0.3 1.2
Medication: Atenolol 0.1 0.2 0.2 -0.4 -0.4
Medication: Levothyroxine sodium 0.8 1.4 2.6 0.4 1.6
Sitting height 0.5 3.8 7.2 0.7 -2.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.1 0.4 -1.1
High blood pressure (mother) 0.3 0.4 0.5 -0.6 0.7
Body mass index (BMI) 0.0 0.2 0.3 0.2 0.5
Impedance of leg (left) 0.4 1.8 3.3 1.8 0.5
Leg predicted mass (left) 0.6 3.4 6.8 -0.2 -2.6
Trunk fat mass 0.7 3.0 4.9 1.1 -2.2
Waist circumference 0.2 0.6 1.2 0.2 1.1
Number of incorrect matches in round 0.5 0.8 1.6 -0.3 -1.3
Past tobacco smoking 0.0 0.1 0.1 -0.3 0.2
Alcohol usually taken with meals 1.2 2.0 3.2 -0.9 -1.8
Nervous feelings 0.1 0.2 0.4 0.7 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.4 -1.2 0.2
Hearing difficulty/problems with background noise 0.4 0.7 1.0 1.0 -0.6
Hair/balding pattern: Pattern 2 0.5 0.6 1.3 -1.1 0.1
Had menopause 0.3 0.4 0.9 -0.0 -0.9
Had other major operations 1.1 1.4 1.9 1.0 -1.4
Forced vital capacity (FVC) 1.0 3.7 7.2 0.3 -2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.9 0.9 0.2
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.1 1.5 -0.5
Qualifications: None of the above 0.3 0.7 1.4 1.2 -0.2
Financial difficulties in last 2 years 1.0 1.4 2.3 0.6 1.5
Mouth/teeth dental problems 0.3 0.5 0.8 0.4 -0.9
Heart attack 0.9 1.2 2.4 0.1 1.6
Allergy 0.0 0.1 0.1 -0.2 -0.3
Pain all over the body in last month 0.6 0.7 0.7 0.8 -0.8
Diabetes (self-reported) 0.1 0.2 0.2 -0.5 0.4
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.0 -1.4 -0.1
Medication: Ramipril 2.9 3.7 6.1 -2.5 -1.2
Medication: Simvastatin 2.2 3.2 6.2 -0.4 2.5
Fluid intelligence score 0.1 0.3 0.5 0.1 -0.7
Illnesses of siblings 0.0 0.0 0.1 0.3 -0.1
Neuroticism score 0.0 0.1 0.1 0.1 -0.3
Weight 0.4 1.8 3.5 0.2 -1.9
Impedance of arm (right) 1.3 6.2 6.7 2.4 -2.6
Arm fat percentage (right) 0.5 1.9 2.0 1.4 -1.4
Trunk fat-free mass 0.4 2.5 4.4 -0.8 -2.1
Hip circumference 0.4 1.6 3.0 -0.5 -1.7
Time employed in main current job 2.6 3.0 4.6 -1.2 -2.1
Alcohol intake versus 10 years previously 0.1 0.1 0.1 -0.3 0.2
Father’s age at death 0.0 0.0 0.1 -0.1 -0.3
Worrier / anxious feelings 1.8 3.4 5.3 1.3 -2.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 0.7 0.0
Falls in the last year 0.3 0.4 0.7 -0.8 0.4
Hair/balding pattern: Pattern 3 0.5 0.7 1.2 1.1 -0.4
Number of live births 1.0 1.4 1.8 -1.0 1.3
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 3.1 1.8 -1.6
Pulse rate 1.2 2.0 4.1 -2.0 0.0
Happiness 0.1 0.2 0.3 0.5 -0.2
Noisy workplace 1.3 1.6 2.8 1.7 -0.7
Qualifications: A levels/AS levels or equivalent 0.2 0.3 0.7 -0.1 0.8
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 3.3 -0.9 1.8
Mouth/teeth dental problems: Dentures 0.4 0.6 0.8 -0.6 0.9
Asthma 0.0 0.1 0.1 0.1 -0.4
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.6 4.7 0.7 -2.2
Medication: Cholesterol lowering 3.6 5.6 7.1 -2.7 2.0
Depression (self-reported) 0.4 0.5 0.9 -0.9 -0.4
Medication: Lansoprazole 1.6 1.8 3.7 -1.9 -0.1
Prospective memory result 0.6 0.7 1.2 0.5 -1.1
Lung cancer (father) 0.4 0.5 1.0 -0.0 1.0
Illnesses of mother 0.3 0.4 0.6 0.3 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 2.3 1.2 -1.5
Pulse wave Arterial Stiffness index 2.1 2.4 4.4 -2.1 -0.6
Impedance of arm (left) 1.3 6.0 7.9 2.0 -2.8
Arm fat mass (right) 0.3 1.4 1.7 1.1 -1.3
Trunk predicted mass 0.4 2.5 4.6 -0.7 -2.1
Standing height 1.4 13.6 27.1 -0.0 -5.2
Length of working week for main job 0.1 0.1 0.2 0.1 0.5
Exposure to tobacco smoke at home 0.3 0.3 0.7 -0.0 0.8
Breastfed as a baby 1.9 2.4 4.6 -2.1 0.4
Tense / ‘highly strung’ 0.6 1.1 2.0 -1.4 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.3 -0.1
Hair/balding pattern: Pattern 4 0.7 1.7 2.7 0.8 1.6
Birth weight of first child 1.3 2.3 3.4 1.1 -1.9
Peak expiratory flow (PEF) 1.6 3.8 6.1 2.5 1.2
Pulse wave reflection index 1.3 1.6 1.9 -1.2 -1.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.4 -0.6 0.6
Loud music exposure frequency 1.2 1.3 1.5 1.1 -1.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 -0.0 -0.6
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.2 -1.1 0.5
Blood clot in the leg (DVT) 0.7 0.9 1.7 -0.4 1.3
Medication: Paracetamol 0.6 1.0 1.6 -1.3 -0.6
Headache pain in last month 0.4 0.7 0.8 -0.9 0.8
Medication for cholesterol, blood pressure or diabetes 2.8 4.6 9.0 3.0 0.3
Glaucoma (self-reported) 0.6 0.6 0.8 0.9 0.7
Gout (self-reported) 3.8 5.2 5.4 2.3 2.2
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 3.6 1.0 1.9
Medication: Amlodipine 0.3 0.4 0.6 -0.8 -0.4
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.3 -1.1 1.0
Birth weight 3.5 7.7 7.8 2.8 -2.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 -0.2 0.3
High blood pressure (siblings) 0.1 0.1 0.2 0.5 -0.0
Forced vital capacity (FVC), Best measure 0.8 2.9 5.8 -0.1 -2.4
Body fat percentage 0.5 2.0 2.3 1.5 -1.3
Leg fat percentage (right) 0.2 0.7 1.3 1.2 0.2
Arm fat-free mass (right) 0.2 1.3 2.2 -0.6 -1.5
Exposure to tobacco smoke outside home 1.7 2.3 4.6 -0.2 2.1
Comparative body size at age 10 0.2 0.6 0.7 0.8 0.8
Number of full brothers 1.4 1.8 2.3 -1.5 1.1
Worry too long after embarrassment 0.3 0.5 1.1 -0.1 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.3 0.6
Wheeze or whistling in the chest in last year 0.9 1.6 3.1 -1.8 -0.1
Number of children fathered 0.3 0.3 0.5 0.3 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 -0.3 -0.0
Age at first live birth 0.3 0.5 1.0 -0.3 -1.0
Pulse wave peak to peak time 1.9 2.3 4.5 2.1 0.3
Health satisfaction 1.8 2.3 3.4 1.8 -1.1
Shortness of breath walking on level ground 1.3 1.5 3.0 0.1 1.7
Qualifications: College or University degree 0.2 0.7 1.4 -0.3 1.2
Eye problems/disorders: None of the above 1.5 1.7 3.3 -0.5 -1.8
Mouth/teeth dental problems: Loose teeth 1.8 2.2 4.1 0.5 2.0
Emphysema/chronic bronchitis 0.2 0.2 0.4 -0.6 -0.1
Medication for pain relief, constipation, heartburn 1.3 2.2 2.5 1.4 1.6
Neck or shoulder pain in last month 2.3 3.3 4.9 -1.3 2.2
Medication: Blood pressure 2.8 5.0 8.0 -2.8 -1.4
Angina (self-reported) 0.5 0.7 1.3 -1.1 0.3
Migraine (self-reported) 0.8 1.0 1.9 0.4 -1.4
Medication: Ibuprofen 1.7 2.0 3.0 1.0 -1.7
Medication: Allopurinol 1.2 1.7 2.8 1.7 0.7
Medication: Omeprazole 0.1 0.2 0.3 0.1 0.6
Medication: Seretide 50 evohaler 1.2 1.4 1.7 -1.3 -1.0
Mean time to correctly identify matches 0.4 0.8 1.0 0.8 -1.0
Heart disease (mother) 0.2 0.3 0.5 -0.7 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 -0.3 0.6
Whole body fat mass 0.4 1.8 2.8 0.9 -1.7
Leg fat mass (right) 0.2 0.9 1.3 1.1 -0.8
Arm predicted mass (right) 0.2 1.3 1.9 -0.8 -1.4
Pulse rate, automated reading 1.1 3.6 5.1 -2.3 1.4
Alcohol intake frequency. 0.4 1.0 1.4 1.2 0.7
Comparative height size at age 10 0.4 2.0 3.9 0.2 -2.0
Number of full sisters 0.6 0.8 1.5 0.1 1.2
Suffer from ‘nerves’ 0.0 0.0 0.0 0.1 -0.2
Overall health rating 0.1 0.3 0.6 0.8 0.2
Chest pain or discomfort 0.5 0.7 1.4 0.2 -1.2
Had major operations 1.3 1.5 2.7 -1.6 -0.5
Age at last live birth 0.2 0.2 0.4 -0.6 0.2
Family relationship satisfaction 0.7 0.9 1.0 -1.0 -0.9
Leg pain on walking 0.5 0.7 1.2 -0.4 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.4 -0.6 0.7
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.5 0.1
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 4.3 0.1 -2.1
Medication: Aspirin 2.5 3.3 3.7 -1.9 1.7
Supplements: Vitamin C 1.0 1.2 2.1 -1.5 -0.5
Knee pain experienced in last month 0.3 0.4 0.8 -0.1 0.9
Hypertension (Self-reported) 1.2 3.2 6.3 -2.5 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.7 -0.5 1.3
Illnesses of father: Heart disease 2.7 3.8 6.2 2.5 1.2
Illnesses of siblings: Diabetes 0.3 0.3 0.4 -0.6 0.6
Smoking status: Previous 0.2 0.3 0.3 0.6 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.3 -0.9 -1.1
Whole body fat-free mass 0.5 2.8 5.2 -0.7 -2.3
Leg fat-free mass (right) 0.8 4.5 8.4 -0.7 -2.9
Arm fat percentage (left) 0.4 1.8 1.8 1.4 -1.3
Average weekly red wine intake 0.3 0.4 0.8 -0.1 -0.9
Handedness (chirality/laterality): Left-handed 1.3 1.5 1.8 -1.2 -1.3
Mood swings 0.3 0.5 0.8 0.9 -0.4
Loneliness, isolation 2.9 4.0 5.7 -2.4 1.5
Long-standing illness, disability or infirmity 2.6 4.0 5.3 2.3 1.6
Ever had bowel cancer screening 1.1 1.3 2.3 -1.5 0.5
Diabetes diagnosed by doctor 0.8 1.2 2.3 -0.4 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.1 1.0 1.0
Friendships satisfaction 0.5 0.7 1.2 0.4 1.1
Qualifications: nursing, teaching 1.0 1.6 3.2 0.2 1.8
Commuting to job workplace: Walk 0.5 0.6 0.8 -0.5 0.9
Eye problems/disorders: Cataract 0.1 0.2 0.3 -0.1 0.6
Mouth/teeth dental problems: Mouth ulcers 1.2 1.8 3.5 1.9 0.4
Medication for cholesterol 1.6 2.5 3.1 -1.4 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.1 -0.2
Back pain experienced in last month 2.2 3.2 4.3 -2.1 -1.4
Mineral and other dietary supplements 2.3 3.0 3.6 1.9 1.6
Breast cancer (self-reported) 0.3 0.4 0.6 0.7 0.4
Asthma (self-reported) 0.1 0.1 0.2 -0.3 -0.4
Osteoporosis (self-reported) 2.0 2.5 4.3 -0.8 -2.1
Osteoarthritis (self-reported) 1.0 1.2 2.4 -0.3 -1.5
Medication: Aspirin 2.7 3.5 3.7 -1.9 1.8
Medication: Gliclazide 0.4 0.5 0.5 -0.6 0.7
Illnesses of father: None of the above (group 1) 2.0 2.5 2.7 -1.6 -1.5
Smoking status: Current 0.8 1.3 1.8 1.4 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.5 1.6 -0.2
Whole body water mass 0.5 3.0 5.6 -0.7 -2.4
Leg predicted mass (right) 0.8 4.4 8.3 -0.7 -2.9
Arm fat mass (left) 0.3 1.4 2.1 0.8 -1.4
Number of self-reported non-cancer illnesses 1.1 1.8 2.4 -1.5 1.1
Average weekly champagne plus white wine intake 0.3 0.5 0.5 0.6 -0.7
Miserableness 0.1 0.2 0.5 0.7 0.1
Guilty feelings 0.8 1.2 1.8 -1.4 0.8
Wears glasses or contact lenses 0.2 0.3 0.5 -0.1 0.7
Ever taken oral contraceptive pill 0.8 0.9 1.1 1.0 0.8
Hearing aid user 1.2 1.3 1.7 1.3 1.0
Mother’s age at death 1.4 1.8 3.5 -1.9 0.2
Financial situation satisfaction 0.2 0.2 0.4 0.6 0.1
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.7 0.9 -0.3
Commuting to job workplace: Public transport 0.2 0.3 0.6 0.0 0.8
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 0.0 0.0
Medication: Blood pressure 0.2 0.3 0.5 -0.3 0.7
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.7 0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 -1.0 -0.1
High cholesterol (Self-reported) 1.6 2.8 3.6 -1.4 1.9
Medication: Bendroflumethiazide 1.0 1.6 2.0 -1.1 -1.4
Medication: Paracetamol 0.7 1.0 1.9 -1.4 -0.5
Medication: Lisinopril 0.2 0.2 0.4 -0.0 0.7
Medication: Atorvastatin 0.6 0.8 1.4 -1.2 0.4
Illnesses of father: High blood pressure 1.4 1.7 2.0 -1.2 1.4
Alcohol drinker status: Never 0.2 0.3 0.5 0.3 -0.7
Ever smoked 0.0 0.1 0.1 0.3 0.2
Basal metabolic rate 0.5 2.6 5.1 -0.4 -2.3
Leg fat percentage (left) 0.1 0.4 0.7 0.9 -0.1
Arm fat-free mass (left) 0.3 1.4 2.2 -0.7 -1.5
Number of operations (self-reported) 0.3 0.4 0.9 0.2 -0.9
Average weekly beer plus cider intake 0.0 0.1 0.1 0.2 0.3
Irritability 0.3 0.5 0.5 -0.7 0.7
Risk taking 0.6 0.9 1.2 -0.8 1.1
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.1 0.3 -0.1
Fractured/broken bones in last 5 years 2.2 2.8 3.9 -2.0 1.3
Age started oral contraceptive pill 0.3 0.4 0.5 -0.4 0.7
Diastolic blood pressure, automated reading 0.3 1.0 1.8 -1.4 -0.4
Ever depressed for a whole week 1.6 2.0 3.0 1.7 -1.0
Unable to work because of sickness or disability 0.1 0.2 0.3 -0.1 0.6
Commuting to job workplace: Cycle 1.2 1.4 2.5 -0.6 -1.6
Myopia 1.5 2.2 4.2 0.5 2.0
Vascular/heart problems diagnosed by doctor 0.6 1.8 3.5 1.9 0.1
Cholesterol lowering medication 1.1 1.6 1.8 1.1 1.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 -0.1 0.5
Pain experienced in last month 1.3 2.2 4.0 2.0 -0.6
Supplements: Calcium 0.6 0.7 1.4 -0.1 -1.2
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 -0.3 -0.4
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.8 0.0 1.7
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.3 -0.4 1.1
Heart disease (siblings) 0.2 0.3 0.4 0.7 0.3
Alcohol drinker status: Previous 0.0 0.0 0.0 -0.0 0.2
Pack years of smoking 5.9 8.6 13.0 -2.0 3.6
Impedance of whole body 0.7 3.5 5.5 2.4 -1.2
Leg fat mass (left) 0.3 1.0 1.2 0.9 -1.1
Arm predicted mass (left) 0.3 1.3 2.4 -0.6 -1.5