Hub : Genes

CTC-518P12.6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.217	0.0570	0.00040	0.144	NA	0.155	NA	0.171	5.9e-11	NA	1.1e-11	NA	7.8e-13
2	GTEx	Nerve Tibial	0.166	0.0466	0.00004	0.006	NA	0.047	NA	0.032	1.1e-01	NA	2.8e-04	NA	2.3e-03
3	GTEx	Testis	0.262	0.0850	0.00250	-0.004	NA	0.060	NA	0.027	5.7e-01	NA	1.2e-03	NA	2.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.7	2.7	6.5	1.2	-0.3	2.5
Bipolar Disorder or Schizophrenia	1.3	3.2	7.6	0.5	-1.3	2.8
Depressed Affect (Nagel 2018)	0.8	1.7	3.3	-1.8	-0.5	1.2
Depression (Nagel 2018)	0.6	0.9	2.1	-0.2	1.4	0.8
Intelligence (Savage-Jansen 2018)	1.4	4.4	11.1	-0.6	3.3	-1.3
Neuroticism (Nagel 2018)	1.7	4.0	8.8	-1.1	-1.4	3.0
Schizophrenia (2018)	0.7	1.6	2.5	-0.2	-1.4	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	2.9	0.6	-1.7	0.1
Worry (Nagel 2018)	3.1	6.6	18.7	0.6	-0.9	4.3
Alzheimer’s Disease (in mother)	0.6	0.7	0.9	0.5	1.0	1.0
Alzheimer’s Disease (in father)	0.6	0.6	1.1	0.7	0.6	-1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.4	0.9	0.1
Crohns Disease (2017)	0.7	1.6	2.1	-1.5	-1.1	-1.2
Irritable Bowel Disease (IBD)	0.1	0.1	0.4	-0.6	0.1	-0.2
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.4	0.8	0.4
Major Depression (MDD)	1.3	1.6	4.6	0.0	2.2	0.1
Reaction Time	2.5	4.7	9.9	1.3	-1.6	3.1
Verbal and Numeric Reasoning (VNR)	2.5	6.1	13.8	0.3	3.7	-2.1
Breast Cancer	0.4	1.0	2.0	0.8	-1.4	-0.4
Ovarian Cancer	0.1	0.2	0.2	0.3	0.5	-0.4
Prostate Cancer	0.3	0.4	1.0	0.1	-1.0	-0.4
Age at First Birth	0.3	0.5	0.9	-0.6	0.5	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.2	-0.1	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.7	1.1	1.7	-1.3	-1.0	-0.8
Mean Putamen Volume	0.5	0.6	1.8	0.1	-0.2	1.3
Fasting Glucose	1.6	1.9	3.1	-1.8	-0.4	1.5
HbA1C	1.2	1.3	3.0	0.2	1.7	-0.9
HDL Cholesterol	0.6	1.0	2.8	-0.2	-1.7	0.1
LDL Cholesterol	0.6	1.0	2.8	0.2	1.7	-0.5
Lupus	1.1	1.7	2.9	0.7	1.3	1.7
Neuroticism (2016)	0.7	1.0	1.5	-0.6	-1.1	1.2
Primary Biliary Cirrhosis	1.5	2.2	4.0	1.0	1.3	2.0
Rheumatoid Arthritis	6.3	8.6	9.5	2.7	-3.1	3.0
Schizophrenia (2014)	0.9	2.0	3.5	0.7	-1.4	1.9
Triglycerides	0.4	0.7	1.3	1.1	-0.9	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.2	-1.1	-1.0	0.4
Ulcerative Colitis	0.3	0.5	1.2	0.4	-0.2	1.1
Blood Eosinophil Count	0.6	4.5	10.0	-1.3	-1.4	-3.2
Blood Platelet Count	0.1	0.8	2.0	-1.4	0.0	0.5
Blood Red Count	0.0	0.4	0.7	-0.9	-0.7	0.1
Blood White Count	0.6	4.4	7.4	1.3	-2.7	-2.1
Heel T-Score	0.4	3.0	4.2	1.6	2.1	-1.5
BMI	0.1	0.6	1.7	0.3	-1.3	0.2
Height	1.0	20.1	52.4	-2.3	7.2	-1.6
Waist Hip Ratio (WHR)	0.2	1.0	2.6	-0.7	-1.6	0.0
Systolic Blood Pressure	0.1	0.7	1.3	-0.9	0.4	-1.2
Smoking Status	0.9	2.1	3.3	-1.5	-1.0	-1.8
Allergy or Eczema	0.6	1.5	3.9	0.7	-0.3	2.0
Cardiovascular Disease	0.2	0.5	1.0	0.6	1.0	0.4
Hypothyroidism (self reported)	3.8	8.7	25.8	-0.2	-0.6	5.1
Respiratory disease	0.2	0.4	0.7	-0.6	0.8	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.7	-0.8	0.2
Lung FEV1/FVC ratio	0.6	2.8	4.7	1.9	2.2	-0.3
Lung FVC	0.2	0.9	1.9	-0.2	0.9	1.4
Neuroticism	2.3	5.6	15.8	-0.7	-0.7	4.0
Chronotype (morning person)	2.2	5.0	12.3	1.6	0.5	3.5
Hair Pigment	0.0	0.8	2.1	0.1	-0.6	-1.4
Tanning	0.1	0.7	1.4	1.2	0.2	0.8
Hand grip strength (left)	1.1	2.8	7.0	0.4	1.1	-2.6
Number of treatments/medications taken	1.3	2.3	5.7	-0.3	2.4	-1.0
Average weekly spirits intake	1.6	1.9	4.8	0.6	-2.2	-0.8
Sensitivity / hurt feelings	1.9	3.2	6.9	-0.4	-1.6	2.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.1	-1.4	0.5	1.2
Hearing difficulty/problems: Yes	0.8	1.2	2.2	-1.5	0.7	-0.9
Relative age of first facial hair	0.2	0.5	0.8	-0.9	0.1	0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	0.4	-0.1	1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	-1.0	-0.4	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.7	-0.2	-0.2
Systolic blood pressure, automated reading	0.2	0.5	0.7	-0.8	0.5	-0.8
Eye problems/disorders: Diabetes related eye disease	3.8	4.2	9.9	-3.2	-1.3	1.0
Angina	0.3	0.4	0.6	-0.8	-0.8	-0.0
Medication for hormone replacement therapy	0.1	0.1	0.4	0.1	-0.1	0.6
Vitamin and mineral supplements	0.3	0.4	0.7	-0.8	0.6	0.4
Supplements: Zinc	0.2	0.2	0.4	-0.6	-0.5	-0.1
Medication: Co-codamol	0.2	0.3	0.8	-0.9	-0.1	-0.0
Medication: Metformin	1.7	2.4	3.5	-1.2	-1.9	1.5
Diabetes (father)	1.0	1.2	2.0	-0.7	-1.4	1.1
Diabetes (mother)	1.0	1.2	3.0	0.7	0.4	-1.7
Severe depression (siblings)	0.6	0.7	1.6	0.4	0.6	1.3
Pack years adult smoking proportion	0.6	0.9	1.6	-1.0	1.2	0.3
Impedance of leg (right)	0.3	1.2	2.2	0.4	-1.1	1.5
Leg fat-free mass (left)	0.1	0.4	0.7	-0.8	0.4	-0.5
Trunk fat percentage	0.4	1.5	3.7	0.1	-1.9	0.9
Hand grip strength (right)	0.8	2.2	4.1	-0.5	1.5	-2.0
Townsend deprivation index at recruitment	1.2	1.7	4.5	-2.1	0.1	0.7
Current tobacco smoking	0.5	0.9	1.0	-0.8	-1.0	1.0
Average weekly fortified wine intake	1.1	1.2	2.3	1.2	1.5	0.1
Maternal smoking around birth	0.0	0.0	0.0	0.0	-0.1	0.1
Fed-up feelings	0.6	1.1	1.3	-1.1	-1.1	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.6	-0.4	-0.7
Relative age voice broke	0.0	0.1	0.1	0.4	0.0	-0.3
Taking other prescription medications	0.9	1.4	1.7	-0.9	1.3	1.3
Age when periods started (menarche)	0.1	0.2	0.3	-0.6	-0.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.2	0.8	-0.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.0	-0.2	1.0	-0.9
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.2	-1.4	0.4	-1.8
Qualifications: CSEs or equivalent	0.4	0.5	1.1	1.1	-0.5	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.4	-1.2	0.6	-0.3
High blood pressure	0.5	1.5	2.4	-0.4	1.5	-1.4
Hayfever, allergic rhinitis or eczema	0.7	1.4	3.8	0.7	-0.1	1.9
Multivitamins +/- minerals	0.6	0.7	1.8	1.3	0.5	-0.3
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.2	-0.9	-0.2
Supplements: Glucosamine	1.9	2.5	6.4	-2.5	-0.0	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.1	0.0	0.4	-1.0
Medication: Atenolol	2.1	2.6	4.8	-2.2	1.7	-0.2
Medication: Levothyroxine sodium	2.4	4.1	12.1	0.6	-0.1	3.5
Sitting height	0.4	2.6	4.9	-2.2	1.7	0.2
Chronic bronchitis/emphysema (father)	1.3	1.6	2.9	-1.7	-1.3	-0.3
High blood pressure (mother)	2.9	4.1	6.9	2.6	-2.2	-0.5
Body mass index (BMI)	0.3	1.3	3.9	0.0	-2.0	-0.3
Impedance of leg (left)	0.2	1.1	2.4	0.4	-0.8	1.6
Leg predicted mass (left)	0.1	0.4	0.7	-0.8	0.3	-0.6
Trunk fat mass	0.2	0.7	1.6	-0.3	-1.3	0.6
Waist circumference	0.3	0.9	1.6	-1.1	-1.3	-0.2
Number of incorrect matches in round	0.6	0.9	1.5	0.1	-1.2	-1.2
Past tobacco smoking	1.4	2.6	3.0	1.7	-1.4	1.7
Alcohol usually taken with meals	0.7	1.1	1.7	0.9	-0.8	1.3
Nervous feelings	2.2	4.2	11.2	1.1	-0.3	3.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.7	-0.6	0.1	1.9
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.8	0.4	-0.5
Hair/balding pattern: Pattern 2	0.5	0.7	1.0	-0.8	-1.0	0.6
Had menopause	0.7	0.9	2.6	-1.6	-0.3	-0.1
Had other major operations	0.3	0.4	1.0	-1.0	-0.3	0.4
Forced vital capacity (FVC)	0.6	2.3	6.8	0.4	2.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	0.1	1.1	-1.0
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	2.5	-1.2	-1.4	-1.6
Qualifications: None of the above	0.4	0.8	1.9	-0.5	-1.4	-0.4
Financial difficulties in last 2 years	2.0	2.7	4.7	-1.6	-1.0	-2.2
Mouth/teeth dental problems	1.1	1.7	4.4	-0.8	-2.1	0.5
Heart attack	0.4	0.6	1.5	-1.2	-0.4	0.2
Allergy	0.8	1.8	5.5	-0.2	-0.0	-2.3
Pain all over the body in last month	2.2	2.4	6.4	-0.5	0.8	2.5
Diabetes (self-reported)	0.4	0.7	1.4	-0.6	-0.5	1.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.9	-2.0	-0.5	0.9
Medication: Ramipril	1.1	1.5	3.4	-0.8	1.8	-0.6
Medication: Simvastatin	0.7	1.0	2.8	0.4	1.7	0.4
Fluid intelligence score	3.0	6.2	11.4	0.6	3.4	-2.6
Illnesses of siblings	1.1	1.5	4.1	-0.7	0.1	2.0
Neuroticism score	1.9	3.9	9.8	0.1	-1.4	3.1
Weight	0.1	0.3	0.6	-0.8	-0.2	-0.5
Impedance of arm (right)	0.2	1.0	2.7	-0.5	0.4	1.6
Arm fat percentage (right)	0.5	2.1	5.9	0.2	-2.4	0.7
Trunk fat-free mass	0.4	2.1	3.3	-0.8	1.5	-1.8
Hip circumference	0.0	0.1	0.2	-0.1	0.3	-0.5
Time employed in main current job	1.4	1.6	3.3	1.8	0.1	1.2
Alcohol intake versus 10 years previously	0.4	0.5	0.9	-1.0	0.8	0.2
Father’s age at death	0.3	0.4	0.5	0.7	0.0	-0.7
Worrier / anxious feelings	1.2	2.3	6.3	0.6	-0.5	2.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.7	-1.2	-0.4	1.3
Falls in the last year	1.7	2.3	3.9	-0.1	1.7	2.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.6	0.5	-0.1
Number of live births	3.0	4.3	6.9	-2.6	-0.2	-2.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.8	0.8	2.2	-0.2
Pulse rate	3.8	6.5	11.4	1.9	3.4	-2.1
Happiness	0.6	0.7	1.9	-1.4	-0.2	0.5
Noisy workplace	1.9	2.4	4.8	-2.2	0.4	1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	0.7	1.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	-0.1	0.4	1.3
Mouth/teeth dental problems: Dentures	1.7	2.8	6.2	-1.3	2.5	-0.6
Asthma	0.4	0.7	1.9	0.5	1.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	5.3	0.1	-2.3	0.7
Medication: Cholesterol lowering	1.5	2.4	5.0	1.2	2.2	0.9
Depression (self-reported)	0.2	0.3	0.6	-0.8	0.3	0.3
Medication: Lansoprazole	1.5	1.7	2.6	-1.6	-1.5	0.4
Prospective memory result	0.4	0.5	1.2	0.4	-1.1	0.4
Lung cancer (father)	3.6	4.2	6.7	-2.3	-2.6	-0.9
Illnesses of mother	1.0	1.2	2.2	-1.5	0.9	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.9	1.7	2.0	-0.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	-0.4	-0.7	0.5
Impedance of arm (left)	0.1	0.7	2.1	0.2	0.0	1.4
Arm fat mass (right)	0.4	1.5	4.5	-0.1	-2.1	0.2
Trunk predicted mass	0.4	2.1	3.1	-0.9	1.5	-1.8
Standing height	0.6	6.3	14.8	-2.0	3.9	-0.5
Length of working week for main job	0.4	0.4	1.2	-0.2	1.1	-0.1
Exposure to tobacco smoke at home	2.5	2.9	5.1	-2.3	1.3	-1.3
Breastfed as a baby	1.3	1.6	4.6	2.1	-0.5	-0.3
Tense / ‘highly strung’	2.0	3.4	9.8	-0.1	-0.6	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	6.1	-2.1	-0.5	2.5
Hair/balding pattern: Pattern 4	0.6	1.4	3.6	0.5	1.9	-0.5
Birth weight of first child	0.7	1.2	2.8	0.0	1.7	1.0
Peak expiratory flow (PEF)	1.0	2.2	5.1	0.5	2.3	-1.2
Pulse wave reflection index	3.4	4.2	5.9	-1.8	-2.4	1.9
Ever highly irritable/argumentative for 2 days	2.1	2.5	6.7	1.0	-2.6	-0.1
Loud music exposure frequency	0.2	0.2	0.3	0.6	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.7	0.2	0.8	0.0
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.0	2.2	-0.0	-1.4
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.7	0.0	0.2
Medication: Paracetamol	0.6	1.0	1.7	-1.2	-1.3	-0.3
Headache pain in last month	0.8	1.3	2.8	-0.8	-1.7	-0.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.5	-0.7	-2.4	-0.0
Glaucoma (self-reported)	1.6	1.8	3.3	-0.7	1.3	-1.8
Gout (self-reported)	0.8	1.1	2.5	1.6	0.4	0.9
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	11.3	-0.0	0.1	3.4
Medication: Amlodipine	1.6	2.3	3.6	-0.6	1.7	-1.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.4	-0.8	-0.6
Birth weight	2.1	4.5	12.9	0.1	3.6	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.7	-0.7	-1.1
High blood pressure (siblings)	2.1	3.1	8.8	0.4	-0.5	-3.0
Forced vital capacity (FVC), Best measure	0.7	2.4	5.5	1.3	2.3	-0.1
Body fat percentage	0.5	1.8	4.8	0.1	-2.2	0.7
Leg fat percentage (right)	0.8	2.9	8.2	-0.1	-2.9	0.8
Arm fat-free mass (right)	0.1	0.7	1.4	-0.8	0.2	-1.2
Exposure to tobacco smoke outside home	0.8	1.0	1.4	-1.2	0.8	-1.0
Comparative body size at age 10	0.6	1.5	2.1	1.0	1.4	1.3
Number of full brothers	0.8	1.0	2.1	-1.4	0.1	-0.9
Worry too long after embarrassment	1.3	2.2	3.8	0.1	-1.9	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.2	0.4	0.6
Wheeze or whistling in the chest in last year	1.2	2.1	3.2	-0.6	-1.8	1.6
Number of children fathered	0.8	0.9	2.4	0.5	-0.1	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.8	0.7	1.9	-0.0
Age at first live birth	0.1	0.3	0.7	0.1	0.8	-0.2
Pulse wave peak to peak time	0.3	0.4	0.8	0.2	0.9	-0.6
Health satisfaction	0.7	0.9	2.6	-0.3	-1.6	-0.0
Shortness of breath walking on level ground	0.5	0.6	1.1	-0.4	-0.7	1.1
Qualifications: College or University degree	0.7	2.1	5.8	2.4	0.6	-0.1
Eye problems/disorders: None of the above	1.2	1.4	3.3	0.8	-1.8	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	-1.1	0.7	0.4
Emphysema/chronic bronchitis	0.9	1.0	1.5	-1.2	-0.2	1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.9	0.3	0.4
Neck or shoulder pain in last month	0.4	0.6	1.1	0.7	-0.5	-1.0
Medication: Blood pressure	1.4	2.4	7.2	0.3	2.7	-0.1
Angina (self-reported)	0.4	0.6	0.9	-1.0	-0.9	-0.2
Migraine (self-reported)	0.3	0.4	0.6	0.2	0.7	-0.7
Medication: Ibuprofen	0.6	0.7	1.8	-0.3	-1.4	-0.4
Medication: Allopurinol	0.5	0.7	1.9	1.4	-0.1	-0.4
Medication: Omeprazole	0.3	0.3	0.9	-0.9	-0.1	0.1
Medication: Seretide 50 evohaler	0.4	0.4	0.6	0.4	0.7	0.8
Mean time to correctly identify matches	1.2	2.3	4.9	0.2	-1.4	2.2
Heart disease (mother)	1.2	1.4	2.4	-1.2	0.7	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.0	0.2	-1.7	-0.0
Whole body fat mass	0.2	0.8	2.3	-0.0	-1.5	0.3
Leg fat mass (right)	0.4	1.7	4.7	-0.2	-2.2	0.7
Arm predicted mass (right)	0.2	0.9	1.7	-0.7	0.7	-1.3
Pulse rate, automated reading	1.8	5.9	11.7	1.0	3.4	-2.2
Alcohol intake frequency.	1.9	4.5	9.9	-1.8	-0.6	3.1
Comparative height size at age 10	1.6	8.9	19.2	-2.7	4.4	-0.4
Number of full sisters	1.6	1.9	2.5	-1.6	-1.1	1.4
Suffer from ‘nerves’	2.2	3.4	7.0	1.1	-1.4	2.6
Overall health rating	1.4	3.0	5.9	-0.9	-1.5	2.4
Chest pain or discomfort	0.6	0.9	1.8	-1.3	-0.5	-0.9
Had major operations	0.2	0.2	0.5	-0.2	0.1	-0.7
Age at last live birth	0.1	0.1	0.3	0.2	0.1	-0.6
Family relationship satisfaction	0.4	0.5	1.5	-0.3	-1.2	0.0
Leg pain on walking	0.1	0.1	0.3	0.1	-0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.3	-0.6	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-0.1	-0.4	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.5	1.2	-1.0	0.7
Medication: Aspirin	0.7	1.0	1.4	0.8	0.9	-1.2
Supplements: Vitamin C	0.3	0.3	0.5	0.7	0.3	0.5
Knee pain experienced in last month	0.3	0.4	0.6	-0.6	-0.7	-0.6
Hypertension (Self-reported)	0.4	1.1	2.8	-0.4	1.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-0.5	-1.0	0.5
Illnesses of father: Heart disease	0.8	1.1	3.1	-0.3	1.8	-0.1
Illnesses of siblings: Diabetes	1.4	1.7	2.9	1.3	1.7	0.7
Smoking status: Previous	1.5	2.2	4.0	-1.1	1.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.1	-0.7	1.0	0.3
Whole body fat-free mass	0.2	1.4	2.0	-1.0	1.1	-1.4
Leg fat-free mass (right)	0.1	0.7	1.0	-1.0	0.8	-0.6
Arm fat percentage (left)	0.6	2.3	6.6	0.3	-2.6	0.5
Average weekly red wine intake	0.4	0.6	1.8	-0.0	0.2	1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-0.3	-0.3	1.2
Mood swings	2.2	4.0	7.4	-1.4	-1.6	2.7
Loneliness, isolation	0.8	1.1	2.3	-0.8	-1.5	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	0.9	-1.0	-0.8	0.5
Ever had bowel cancer screening	0.2	0.3	0.7	0.3	0.1	0.8
Diabetes diagnosed by doctor	0.5	0.9	1.3	-0.7	-1.0	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	-0.9	-0.6	-0.5
Friendships satisfaction	1.0	1.2	3.0	-0.7	-1.7	0.3
Qualifications: nursing, teaching	0.9	1.5	2.6	-1.0	1.6	-0.9
Commuting to job workplace: Walk	2.0	2.2	6.2	-2.5	0.5	0.3
Eye problems/disorders: Cataract	0.8	1.0	1.7	-0.8	1.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	0.2	-1.1	0.6
Medication for cholesterol	0.3	0.4	0.7	0.9	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	0.3	0.8	-1.1
Back pain experienced in last month	0.4	0.6	1.2	-1.1	0.4	-0.7
Mineral and other dietary supplements	1.4	1.9	3.6	1.9	-1.3	-0.7
Breast cancer (self-reported)	2.1	2.5	6.5	-2.5	0.7	-0.8
Asthma (self-reported)	0.3	0.6	1.1	0.6	1.1	0.5
Osteoporosis (self-reported)	0.7	0.9	2.1	-0.3	1.4	0.7
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.8	-0.8	0.2
Medication: Aspirin	1.3	1.7	2.4	1.5	1.1	-1.3
Medication: Gliclazide	1.0	1.1	1.6	-1.2	-1.3	0.6
Illnesses of father: None of the above (group 1)	1.2	1.4	2.5	0.7	-1.6	1.1
Smoking status: Current	0.5	0.7	1.2	-0.8	-1.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.8	2.2	0.3	0.3
Whole body water mass	0.2	1.4	1.9	-1.1	1.0	-1.4
Leg predicted mass (right)	0.1	0.6	0.9	-1.0	0.8	-0.6
Arm fat mass (left)	0.4	1.5	4.5	0.0	-2.1	0.2
Number of self-reported non-cancer illnesses	0.8	1.4	4.0	-0.5	0.2	2.0
Average weekly champagne plus white wine intake	1.3	1.8	5.2	0.5	2.3	0.1
Miserableness	1.1	1.9	5.1	-2.2	0.1	0.8
Guilty feelings	1.3	1.9	4.1	-0.8	-2.0	1.1
Wears glasses or contact lenses	0.5	0.6	1.6	-0.1	1.3	0.2
Ever taken oral contraceptive pill	0.4	0.4	1.3	0.1	-1.1	0.1
Hearing aid user	1.3	1.4	2.3	-1.4	1.5	0.0
Mother’s age at death	0.1	0.1	0.1	-0.3	-0.3	0.2
Financial situation satisfaction	0.8	0.9	2.3	-1.5	-0.6	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.2	-0.9	0.8
Commuting to job workplace: Public transport	1.3	1.6	3.9	-0.3	2.0	0.9
Eye problems/disorders: Glaucoma	2.2	2.6	6.9	-0.6	0.7	-2.6
Medication: Blood pressure	1.0	1.9	2.3	-1.5	1.5	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	-0.2	-1.2	-0.5
Supplements: Fish oil (including cod liver oil)	1.1	1.5	2.6	-1.6	1.3	-0.1
High cholesterol (Self-reported)	0.3	0.5	0.8	0.9	0.6	0.7
Medication: Bendroflumethiazide	0.5	0.7	1.3	0.7	1.1	-0.5
Medication: Paracetamol	0.5	0.8	1.4	-1.2	-1.0	-0.2
Medication: Lisinopril	0.8	1.0	2.8	1.7	0.3	0.4
Medication: Atorvastatin	1.0	1.2	2.5	-0.4	-1.6	1.0
Illnesses of father: High blood pressure	0.9	1.1	1.7	1.3	1.0	-0.6
Alcohol drinker status: Never	1.4	1.7	2.7	-0.7	-1.4	1.7
Ever smoked	0.8	1.4	2.0	-1.4	0.7	-1.3
Basal metabolic rate	0.1	0.6	1.0	-0.8	0.4	-1.0
Leg fat percentage (left)	0.5	1.9	5.2	-0.1	-2.3	0.6
Arm fat-free mass (left)	0.1	0.7	1.4	-0.8	0.1	-1.2
Number of operations (self-reported)	1.0	1.4	2.9	-0.6	1.0	-1.7
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.4	-0.2	-0.5
Irritability	1.1	1.8	3.6	-1.0	-1.0	1.9
Risk taking	0.8	1.2	2.2	1.1	-1.5	-0.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.2	-0.2	-0.4	2.1
Fractured/broken bones in last 5 years	1.1	1.4	2.6	-1.1	0.7	1.6
Age started oral contraceptive pill	0.3	0.4	0.8	0.6	-0.4	0.9
Diastolic blood pressure, automated reading	0.6	1.8	4.7	-0.7	2.2	-0.5
Ever depressed for a whole week	0.3	0.3	0.6	-0.8	0.1	-0.6
Unable to work because of sickness or disability	1.0	1.3	2.5	-1.6	-1.2	0.2
Commuting to job workplace: Cycle	0.2	0.3	0.8	0.3	-0.9	-0.1
Myopia	0.1	0.1	0.2	0.3	0.3	0.4
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.0	0.4	-1.4	1.4
Cholesterol lowering medication	0.3	0.5	0.9	-0.8	-0.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.9	-0.7	-0.3
Pain experienced in last month	0.0	0.1	0.1	0.2	0.4	0.1
Supplements: Calcium	0.4	0.4	1.3	-1.1	0.1	-0.1
Basal cell carcinoma (self-reported)	2.8	3.4	6.3	-0.0	-1.9	-2.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-1.1	-0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.7	0.2	0.4
Heart disease (siblings)	0.4	0.5	0.9	-0.7	1.0	-0.2
Alcohol drinker status: Previous	0.9	1.1	3.1	-0.2	1.8	0.1
Pack years of smoking	0.8	1.2	2.8	-1.0	1.7	-0.1
Impedance of whole body	0.3	1.3	3.5	0.5	-0.5	1.9
Leg fat mass (left)	0.4	1.4	3.6	-0.3	-1.9	0.6
Arm predicted mass (left)	0.2	0.9	1.8	-1.0	0.2	-1.4