Hub : Genes

CTD-2020K17.4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.231	0.090	0.00590	0.019	NA	0.107	NA	0.087	1.0e-01	NA	1.1e-03	NA	3.0e-03
2	GTEx	Esophagus Mucosa	0.231	0.074	0.00067	0.113	NA	0.068	NA	0.094	5.8e-08	NA	2.6e-05	NA	7.2e-07
3	GTEx	Pancreas	0.158	0.056	0.00120	0.139	NA	0.098	NA	0.103	1.9e-06	NA	6.6e-05	NA	4.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.4	0.5	-0.5	0.5	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	0.1	1.0	1.2
Depressed Affect (Nagel 2018)	1.1	2.4	6.7	-2.6	-0.4	-0.6
Depression (Nagel 2018)	0.3	0.4	0.9	0.1	-0.6	-1.0
Intelligence (Savage-Jansen 2018)	0.4	1.4	2.9	0.4	1.7	1.0
Neuroticism (Nagel 2018)	0.9	2.1	5.4	-2.3	0.1	-1.0
Schizophrenia (2018)	0.3	0.7	1.0	0.6	0.9	1.0
Schizophrenia vs Biploar Disorder	1.1	1.4	2.9	1.7	-1.1	-0.2
Worry (Nagel 2018)	0.9	2.0	2.5	-1.5	-1.1	-1.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.6	0.9	-0.2
Alzheimer’s Disease (in father)	2.8	3.0	4.3	-1.3	2.1	1.7
Alzheimer’s Disease (including proxy)	0.9	1.3	2.0	-1.4	1.4	-0.4
Crohns Disease (2017)	1.2	2.7	5.5	2.4	1.5	0.5
Irritable Bowel Disease (IBD)	0.3	0.7	1.5	0.6	1.2	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.4	-0.6	0.3	0.1
Major Depression (MDD)	2.0	2.5	3.4	-1.4	-1.8	-1.4
Reaction Time	0.6	1.1	1.7	-1.3	0.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.8	0.4	0.8
Breast Cancer	0.0	0.0	0.1	-0.1	-0.3	-0.1
Ovarian Cancer	0.3	0.4	0.5	-0.7	0.4	-0.7
Prostate Cancer	0.8	1.1	1.3	-1.2	1.2	0.8
Age at First Birth	1.0	1.5	2.9	-1.7	1.1	0.6
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.1	0.0	0.4
Body Mass Index (BMI) (2010)	1.0	1.4	3.3	-1.8	-1.0	-0.3
Coronary Artery Disease (CAD)	1.0	1.2	1.5	-0.9	1.2	1.1
Crohns Disease (2012)	0.5	0.8	1.6	1.3	0.8	0.5
Mean Putamen Volume	0.1	0.1	0.3	-0.6	-0.2	0.2
Fasting Glucose	0.1	0.1	0.4	0.6	-0.3	0.0
HbA1C	0.2	0.2	0.3	-0.6	0.2	-0.6
HDL Cholesterol	1.1	1.8	5.2	-2.3	-0.1	-0.1
LDL Cholesterol	0.7	1.2	2.9	1.7	0.2	-0.7
Lupus	0.6	0.9	2.1	-0.5	0.6	-1.4
Neuroticism (2016)	0.9	1.3	1.9	-1.4	-1.0	-1.0
Primary Biliary Cirrhosis	1.8	2.6	7.4	2.7	0.3	-0.6
Rheumatoid Arthritis	0.2	0.3	0.9	-0.1	0.3	0.9
Schizophrenia (2014)	0.9	2.0	2.7	1.3	1.6	1.3
Triglycerides	0.7	1.2	3.0	1.7	0.6	-0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	0.6	-0.9	-1.2
Ulcerative Colitis	0.3	0.4	0.9	-0.9	0.4	-0.3
Blood Eosinophil Count	2.4	18.1	32.3	5.7	2.9	3.7
Blood Platelet Count	0.3	3.1	6.5	2.5	1.4	0.9
Blood Red Count	1.1	11.1	30.1	-5.5	-0.8	1.6
Blood White Count	0.3	2.0	3.2	-1.1	-1.2	1.8
Heel T-Score	0.8	6.1	15.8	4.0	0.9	1.3
BMI	0.2	1.1	2.7	0.3	-1.6	-0.8
Height	1.8	33.9	78.9	-8.9	4.8	0.6
Waist Hip Ratio (WHR)	0.2	1.0	1.4	1.1	-1.2	-0.5
Systolic Blood Pressure	4.4	21.9	63.2	8.0	-1.5	-0.5
Smoking Status	1.4	3.4	9.4	3.1	-0.6	-0.6
Allergy or Eczema	1.2	3.2	9.4	3.1	-0.5	0.2
Cardiovascular Disease	1.8	6.1	17.2	4.2	0.2	-1.0
Hypothyroidism (self reported)	1.8	4.2	8.0	-0.1	2.8	2.1
Respiratory disease	2.6	5.7	16.6	4.1	-0.2	0.7
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.6	2.1	-0.5	-0.0
Lung FEV1/FVC ratio	0.1	0.4	1.0	0.2	0.2	1.0
Lung FVC	0.0	0.1	0.3	0.5	-0.1	-0.1
Neuroticism	1.0	2.4	4.2	-2.0	-0.8	-1.6
Chronotype (morning person)	0.7	1.7	3.9	-2.0	-0.4	-1.0
Hair Pigment	0.0	0.5	0.9	-0.6	1.0	0.4
Tanning	0.0	0.2	0.6	-0.8	-0.2	0.1
Hand grip strength (left)	1.8	4.9	12.4	-3.5	-0.9	-1.1
Number of treatments/medications taken	0.5	0.8	1.2	1.1	0.7	0.9
Average weekly spirits intake	0.8	1.0	2.2	0.3	0.9	1.5
Sensitivity / hurt feelings	1.7	3.0	8.6	-2.9	0.6	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	0.7	0.0	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.4	-0.4	0.8
Relative age of first facial hair	0.5	1.0	1.8	-1.3	0.6	0.9
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.4	2.3	-0.4	-0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	1.9	0.6	0.7
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	-0.3	0.7	0.5
Systolic blood pressure, automated reading	4.7	13.7	35.6	6.0	-2.1	-1.0
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.2	0.6	-1.8	-1.8
Angina	1.8	2.4	4.2	2.0	-1.6	-0.4
Medication for hormone replacement therapy	1.7	1.9	2.8	1.7	1.2	1.1
Vitamin and mineral supplements	0.5	0.6	1.3	-1.2	-0.7	-0.3
Supplements: Zinc	1.1	1.2	1.5	0.8	1.2	1.2
Medication: Co-codamol	4.2	4.9	8.4	0.8	-2.9	-2.4
Medication: Metformin	0.2	0.2	0.3	-0.6	-0.4	-0.5
Diabetes (father)	1.2	1.5	3.9	-2.0	0.3	-0.7
Diabetes (mother)	0.6	0.8	1.0	1.0	-0.9	-0.8
Severe depression (siblings)	1.5	1.6	3.0	1.7	0.6	1.3
Pack years adult smoking proportion	2.8	4.3	9.0	3.0	-1.5	-1.3
Impedance of leg (right)	1.6	7.7	21.7	4.7	0.9	-0.9
Leg fat-free mass (left)	1.5	7.8	22.1	-4.7	-0.7	-0.9
Trunk fat percentage	1.0	4.1	9.3	3.1	-1.2	-1.3
Hand grip strength (right)	1.7	4.7	11.5	-3.4	-0.8	-1.4
Townsend deprivation index at recruitment	0.6	0.8	1.5	0.9	-0.2	-1.2
Current tobacco smoking	1.5	2.5	6.1	2.5	1.1	0.5
Average weekly fortified wine intake	0.5	0.6	1.2	0.7	-0.3	1.1
Maternal smoking around birth	0.5	0.8	1.4	0.8	-0.5	-1.2
Fed-up feelings	0.6	1.0	2.2	-1.5	0.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.2	-0.6	-0.9	-1.5
Relative age voice broke	1.7	2.6	5.1	-2.3	-1.2	-1.1
Taking other prescription medications	0.6	0.9	1.5	1.2	0.9	0.6
Age when periods started (menarche)	0.6	1.5	3.3	-1.1	1.8	0.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.7	1.0	1.3	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.3	-1.1	0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.2	0.6	0.2
Qualifications: CSEs or equivalent	0.8	1.0	1.8	0.7	-1.3	-0.8
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.5	-0.2	0.2
High blood pressure	1.6	4.4	11.2	3.3	-0.8	-1.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	2.8	1.6	-1.7	-1.4
Multivitamins +/- minerals	0.2	0.2	0.3	0.1	0.5	-0.6
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.3	-0.7	-0.4
Supplements: Glucosamine	2.0	2.7	7.7	2.8	-0.3	0.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.4	2.1	0.5	0.8
Medication: Atenolol	1.1	1.3	2.8	1.0	-1.7	-0.4
Medication: Levothyroxine sodium	1.4	2.4	3.8	0.8	1.6	1.9
Sitting height	0.9	6.6	17.9	-4.2	1.2	0.6
Chronic bronchitis/emphysema (father)	1.3	1.5	3.1	-0.5	-1.8	-1.1
High blood pressure (mother)	0.7	1.0	2.6	0.7	1.6	0.1
Body mass index (BMI)	0.5	2.3	5.9	-0.1	-2.4	-1.0
Impedance of leg (left)	1.5	7.5	20.6	4.5	1.2	-0.5
Leg predicted mass (left)	1.4	7.5	21.2	-4.6	-0.7	-0.8
Trunk fat mass	0.2	0.9	1.1	0.9	-0.9	-1.0
Waist circumference	0.6	2.1	4.4	-0.0	-2.1	-1.3
Number of incorrect matches in round	0.4	0.7	2.1	0.1	-0.3	-1.5
Past tobacco smoking	0.7	1.4	3.2	-1.8	0.8	0.6
Alcohol usually taken with meals	1.7	2.8	4.0	-1.0	1.8	2.0
Nervous feelings	1.9	3.5	4.3	-2.0	-1.5	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.1	-2.3	-1.0	-2.0
Hearing difficulty/problems with background noise	2.4	3.8	5.6	-1.4	-2.4	-2.0
Hair/balding pattern: Pattern 2	4.1	5.2	7.7	-2.0	-2.0	-2.8
Had menopause	1.2	1.5	2.4	1.6	-0.3	1.4
Had other major operations	0.9	1.1	1.6	1.2	1.3	0.5
Forced vital capacity (FVC)	0.2	0.7	1.7	-1.3	0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.9	0.5	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	-0.6	0.1	0.6
Qualifications: None of the above	0.0	0.0	0.1	0.2	0.1	-0.1
Financial difficulties in last 2 years	1.4	1.8	3.3	-1.8	0.5	-1.4
Mouth/teeth dental problems	1.8	2.8	4.4	2.1	1.4	1.4
Heart attack	0.7	1.0	1.2	0.8	1.0	1.1
Allergy	2.1	4.8	11.6	-3.4	1.7	-0.0
Pain all over the body in last month	1.1	1.2	2.5	1.0	-1.6	0.0
Diabetes (self-reported)	0.1	0.2	0.3	0.6	-0.6	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.8	-0.0	-0.2
Medication: Ramipril	0.8	1.0	2.3	1.5	-0.8	0.4
Medication: Simvastatin	0.1	0.1	0.1	-0.0	0.3	0.4
Fluid intelligence score	0.5	1.0	1.6	-0.5	1.2	1.1
Illnesses of siblings	1.6	2.2	5.1	-2.3	1.0	-0.6
Neuroticism score	1.3	2.7	4.8	-2.2	-0.8	-1.7
Weight	0.5	2.3	6.2	-2.5	-0.7	-0.5
Impedance of arm (right)	2.0	9.3	25.5	5.1	1.3	-0.9
Arm fat percentage (right)	1.0	4.0	6.0	2.4	-1.9	-1.5
Trunk fat-free mass	2.9	16.7	50.1	-7.1	0.3	0.2
Hip circumference	0.1	0.4	0.8	-0.1	-0.9	-0.5
Time employed in main current job	0.2	0.3	0.6	0.3	0.1	0.8
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.3	-0.1
Father’s age at death	2.6	3.6	7.2	0.6	1.8	2.7
Worrier / anxious feelings	0.5	0.9	2.4	-1.5	-0.6	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.5	1.2	-0.1	-0.2
Falls in the last year	0.5	0.7	1.7	-0.6	-1.3	-0.4
Hair/balding pattern: Pattern 3	1.5	2.3	6.2	2.5	-0.4	-0.7
Number of live births	1.1	1.6	3.8	-2.0	0.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	-1.0	0.1	-0.5
Pulse rate	0.9	1.5	2.7	1.6	0.4	1.2
Happiness	0.3	0.3	0.9	-0.9	0.1	0.4
Noisy workplace	0.0	0.0	0.0	-0.2	-0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.7	1.0	1.3	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.1	-0.9	-1.0	-0.8
Mouth/teeth dental problems: Dentures	1.6	2.6	3.9	-2.0	-0.8	-1.8
Asthma	2.8	5.6	10.9	3.3	0.8	2.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.7	-1.9	-0.6	0.3
Medication: Cholesterol lowering	0.4	0.7	1.4	-0.7	1.2	-0.4
Depression (self-reported)	0.9	1.0	1.4	-0.9	-1.2	-0.9
Medication: Lansoprazole	1.1	1.2	3.2	1.8	0.5	0.3
Prospective memory result	0.7	0.9	1.6	-0.5	-0.9	-1.3
Lung cancer (father)	0.1	0.2	0.4	-0.1	-0.7	-0.2
Illnesses of mother	0.4	0.4	0.7	-0.8	-0.9	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.5	-1.2	-0.1	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.4	0.5	0.4
Impedance of arm (left)	2.3	10.5	28.6	5.3	1.7	-0.4
Arm fat mass (right)	0.4	1.6	3.1	0.2	-1.8	-1.3
Trunk predicted mass	3.0	16.9	50.6	-7.1	0.2	0.1
Standing height	1.3	13.1	26.4	-5.1	3.5	0.9
Length of working week for main job	0.7	0.8	1.9	-0.6	-0.3	-1.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.8	-0.5	0.3
Breastfed as a baby	1.4	1.7	4.6	-0.0	0.7	2.1
Tense / ‘highly strung’	0.8	1.4	3.4	-0.1	-0.8	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.2	-2.1	-0.1	0.2
Hair/balding pattern: Pattern 4	1.1	2.7	7.5	2.7	0.6	0.5
Birth weight of first child	4.4	8.0	11.3	-3.4	-1.7	-3.1
Peak expiratory flow (PEF)	0.9	2.1	2.6	-1.4	1.4	1.6
Pulse wave reflection index	0.6	0.8	2.0	-0.3	-0.5	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	-1.0	-0.7	-0.7
Loud music exposure frequency	0.4	0.4	0.7	0.6	-0.9	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	1.0	0.0	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.8	-0.9	0.0	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.5	-0.1	0.4
Medication: Paracetamol	0.1	0.2	0.6	0.1	-0.1	0.7
Headache pain in last month	0.9	1.5	3.8	-1.9	-0.5	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	0.1	-0.1	1.3
Glaucoma (self-reported)	0.7	0.8	1.5	0.1	-1.2	-0.9
Gout (self-reported)	0.8	1.0	1.8	1.1	-0.4	-1.4
Hypothyroidism/myxoedema (self-reported)	2.2	4.2	7.8	-0.0	2.8	2.2
Medication: Amlodipine	0.9	1.3	1.4	1.2	-1.2	-1.1
Medication: Ventolin 100micrograms inhaler	2.6	3.4	7.4	2.7	1.4	0.9
Birth weight	0.4	0.9	1.8	-1.3	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.3	-1.0	-0.7
High blood pressure (siblings)	2.4	3.5	10.0	3.2	-0.1	0.7
Forced vital capacity (FVC), Best measure	0.2	0.8	1.9	-1.4	-0.1	-0.6
Body fat percentage	1.2	4.8	8.1	2.9	-1.9	-1.6
Leg fat percentage (right)	1.5	5.3	6.2	2.5	-2.5	-1.9
Arm fat-free mass (right)	2.5	12.8	38.2	-6.2	-0.5	-0.1
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.7	-0.2	0.4
Comparative body size at age 10	0.2	0.6	1.3	-1.1	0.2	0.6
Number of full brothers	2.7	3.3	5.9	-0.4	-2.4	-2.0
Worry too long after embarrassment	0.9	1.5	2.9	-1.7	-0.4	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	0.3	-1.7	-0.9
Wheeze or whistling in the chest in last year	0.8	1.5	4.1	2.0	-0.3	0.4
Number of children fathered	1.0	1.2	2.7	-1.7	0.4	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	-1.4	-0.3	0.1
Age at first live birth	0.2	0.4	1.1	-0.3	0.1	1.0
Pulse wave peak to peak time	0.2	0.2	0.5	-0.7	-0.2	-0.4
Health satisfaction	0.2	0.2	0.5	-0.0	-0.7	0.3
Shortness of breath walking on level ground	0.3	0.4	0.9	1.0	0.1	0.6
Qualifications: College or University degree	0.2	0.8	2.3	0.1	1.5	-0.1
Eye problems/disorders: None of the above	3.0	3.4	8.1	-2.9	1.3	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	0.5	-0.2	-1.4
Emphysema/chronic bronchitis	1.6	1.8	4.5	2.1	-0.9	-0.3
Medication for pain relief, constipation, heartburn	1.3	2.1	4.3	0.8	-1.2	-2.1
Neck or shoulder pain in last month	1.1	1.5	4.0	2.0	-0.7	-0.1
Medication: Blood pressure	0.6	1.0	2.5	0.2	-0.7	-1.6
Angina (self-reported)	1.4	1.9	3.6	1.9	-1.4	-0.2
Migraine (self-reported)	0.3	0.4	0.7	-0.2	0.7	0.8
Medication: Ibuprofen	1.0	1.2	1.9	-1.2	0.4	1.4
Medication: Allopurinol	0.9	1.2	1.9	1.4	-0.4	-1.2
Medication: Omeprazole	1.5	1.8	3.9	2.0	0.6	1.1
Medication: Seretide 50 evohaler	0.7	0.8	1.5	0.4	0.9	1.2
Mean time to correctly identify matches	0.7	1.3	3.2	-1.8	0.4	-0.7
Heart disease (mother)	1.7	2.1	3.5	1.9	-1.6	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	6.2	-2.5	0.1	0.1
Whole body fat mass	0.3	1.3	2.4	0.5	-1.5	-1.1
Leg fat mass (right)	0.7	2.6	4.9	0.2	-2.2	-1.7
Arm predicted mass (right)	2.5	12.9	38.4	-6.2	-0.6	-0.1
Pulse rate, automated reading	0.4	1.3	2.4	0.8	-1.6	-0.9
Alcohol intake frequency.	0.2	0.5	1.1	-0.4	-1.0	-0.5
Comparative height size at age 10	0.8	4.3	8.8	-3.0	1.9	-0.6
Number of full sisters	0.0	0.0	0.0	0.1	0.0	-0.1
Suffer from ‘nerves’	2.8	4.4	8.4	-1.7	-1.3	-2.9
Overall health rating	1.9	4.0	7.5	2.7	-1.6	-1.4
Chest pain or discomfort	1.8	2.6	7.5	2.7	-0.6	-0.2
Had major operations	1.0	1.1	2.0	-1.2	1.4	-0.0
Age at last live birth	0.6	0.9	2.2	-1.5	0.5	0.6
Family relationship satisfaction	0.2	0.2	0.6	0.2	0.8	-0.3
Leg pain on walking	0.2	0.3	0.4	-0.6	-0.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.8	0.7	-0.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.3	0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	5.7	2.4	-1.1	0.3
Medication: Aspirin	2.8	3.7	6.2	-1.0	2.0	2.5
Supplements: Vitamin C	1.2	1.4	1.8	1.3	1.0	1.2
Knee pain experienced in last month	1.7	2.6	5.1	0.7	-1.6	-2.3
Hypertension (Self-reported)	1.6	4.3	12.0	3.5	-0.6	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.9	5.8	17.2	4.1	-0.1	-0.3
Illnesses of father: Heart disease	0.6	0.8	1.2	-1.0	-0.5	1.1
Illnesses of siblings: Diabetes	0.5	0.7	1.2	0.2	-1.1	-0.9
Smoking status: Previous	0.8	1.2	1.8	1.0	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.3	-1.5	-0.3	-1.3
Whole body fat-free mass	2.3	13.4	40.1	-6.3	-0.1	-0.3
Leg fat-free mass (right)	1.6	8.4	24.7	-5.0	-0.5	-0.4
Arm fat percentage (left)	1.1	4.3	5.9	2.4	-2.1	-1.6
Average weekly red wine intake	0.7	1.0	2.2	-1.5	0.3	-0.8
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.3	2.1	0.8	1.2
Mood swings	1.5	2.6	5.5	-2.3	-0.7	-1.4
Loneliness, isolation	1.5	2.0	3.6	-1.2	-1.9	-1.0
Long-standing illness, disability or infirmity	1.7	2.5	5.3	2.3	-1.5	-0.1
Ever had bowel cancer screening	0.3	0.3	1.0	-0.1	-0.1	1.0
Diabetes diagnosed by doctor	0.5	0.8	1.3	0.7	-1.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.8	-0.1	1.4	0.2
Friendships satisfaction	0.6	0.8	1.8	-1.4	0.6	0.4
Qualifications: nursing, teaching	2.4	3.7	5.9	1.5	1.7	2.4
Commuting to job workplace: Walk	1.4	1.5	3.8	2.0	-0.1	0.8
Eye problems/disorders: Cataract	1.5	1.7	4.4	2.1	-0.7	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.9	-0.7	-0.4
Medication for cholesterol	1.6	2.4	6.1	-2.5	-0.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.3	1.4	-0.2	-1.5
Back pain experienced in last month	0.1	0.2	0.5	-0.7	-0.1	0.1
Mineral and other dietary supplements	1.6	2.2	6.4	-2.5	-0.2	-0.3
Breast cancer (self-reported)	1.9	2.3	4.5	1.3	2.1	0.8
Asthma (self-reported)	3.3	6.5	11.5	3.4	1.1	2.6
Osteoporosis (self-reported)	1.1	1.3	1.6	-1.3	-1.2	-0.9
Osteoarthritis (self-reported)	1.2	1.6	4.2	2.1	0.7	0.2
Medication: Aspirin	1.8	2.4	3.5	-1.2	1.5	1.9
Medication: Gliclazide	3.0	3.4	5.8	-1.1	-1.8	-2.4
Illnesses of father: None of the above (group 1)	2.5	3.1	6.2	2.5	0.3	-1.7
Smoking status: Current	1.8	2.8	7.5	2.7	0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	-0.5	-0.2
Whole body water mass	2.3	13.4	39.9	-6.3	-0.2	-0.3
Leg predicted mass (right)	1.6	8.3	24.7	-5.0	-0.4	-0.4
Arm fat mass (left)	0.3	1.4	2.9	0.2	-1.7	-1.1
Number of self-reported non-cancer illnesses	2.6	4.6	10.8	3.3	1.0	1.4
Average weekly champagne plus white wine intake	0.6	0.9	1.1	-1.0	1.1	0.7
Miserableness	1.1	1.9	3.8	-1.1	-0.9	-1.9
Guilty feelings	0.7	1.1	2.2	-0.5	-0.9	-1.5
Wears glasses or contact lenses	0.3	0.4	0.6	-0.6	0.8	0.5
Ever taken oral contraceptive pill	1.8	2.0	2.6	0.9	-1.6	-1.6
Hearing aid user	0.7	0.8	1.9	0.1	1.4	0.7
Mother’s age at death	0.3	0.4	1.2	-0.1	0.3	1.1
Financial situation satisfaction	0.8	1.0	3.1	1.8	-0.3	0.1
Tinnitus: Yes, now most or all of the time	2.9	3.3	4.8	-0.8	-2.2	-2.2
Commuting to job workplace: Public transport	0.8	0.9	2.1	-0.8	1.5	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.6	-1.0	-0.4
Medication: Blood pressure	2.5	4.8	14.3	3.8	-0.1	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	0.1	0.4	-0.9
Supplements: Fish oil (including cod liver oil)	2.0	2.6	7.2	2.7	-0.6	-0.5
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	-0.3	0.0
Medication: Bendroflumethiazide	0.2	0.3	0.9	1.0	-0.2	0.0
Medication: Paracetamol	0.5	0.8	1.5	0.8	0.5	1.2
Medication: Lisinopril	2.5	3.3	6.3	2.5	1.7	0.7
Medication: Atorvastatin	0.2	0.3	0.8	-0.9	-0.2	0.1
Illnesses of father: High blood pressure	0.6	0.7	1.2	1.1	-0.0	0.9
Alcohol drinker status: Never	0.9	1.1	2.5	-0.8	-1.6	-0.0
Ever smoked	1.1	2.0	4.7	2.2	-1.0	-0.7
Basal metabolic rate	1.8	9.9	29.2	-5.4	-0.4	-0.6
Leg fat percentage (left)	1.3	4.6	5.5	2.3	-2.4	-1.8
Arm fat-free mass (left)	2.4	12.1	35.5	-6.0	-0.6	-0.5
Number of operations (self-reported)	0.7	1.1	2.6	0.5	1.6	0.6
Average weekly beer plus cider intake	2.1	3.0	7.6	2.8	-0.6	-1.0
Irritability	0.9	1.5	2.4	-0.3	1.5	1.4
Risk taking	0.9	1.3	1.6	1.0	1.2	1.3
Ever had prostate specific antigen (PSA) test	3.3	3.8	8.5	0.0	1.7	2.9
Fractured/broken bones in last 5 years	1.8	2.3	4.6	-2.1	1.0	1.1
Age started oral contraceptive pill	1.4	1.7	2.9	-1.5	0.3	1.7
Diastolic blood pressure, automated reading	1.1	3.5	7.0	2.6	-1.6	-1.0
Ever depressed for a whole week	1.7	2.1	4.2	-2.0	-0.3	-1.4
Unable to work because of sickness or disability	3.3	4.3	7.5	0.7	-2.7	-2.2
Commuting to job workplace: Cycle	0.5	0.7	0.9	-0.9	0.9	0.6
Myopia	1.2	1.7	3.8	-2.0	0.2	-1.1
Vascular/heart problems diagnosed by doctor	1.8	5.0	13.0	-3.6	0.7	1.2
Cholesterol lowering medication	1.1	1.5	2.8	1.7	-0.6	1.2
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	5.5	2.3	0.5	1.5
Pain experienced in last month	0.2	0.3	0.7	0.8	0.2	0.5
Supplements: Calcium	3.0	3.3	6.4	0.7	1.7	2.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.7	-0.4	0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.8	0.7	0.9	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.6	0.2	0.6
Heart disease (siblings)	0.5	0.6	1.6	0.2	-1.3	0.4
Alcohol drinker status: Previous	1.2	1.4	3.3	1.0	-0.1	-1.8
Pack years of smoking	2.2	3.3	7.6	2.8	-1.1	-0.9
Impedance of whole body	2.3	11.9	33.4	5.8	1.4	-0.4
Leg fat mass (left)	0.6	2.4	4.9	0.0	-2.2	-1.5
Arm predicted mass (left)	2.2	11.1	32.6	-5.7	-0.6	-0.4