Hub : Genes

CTD-2555O16.4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1060 0.0370 2.2e-04 0.101 NA 0.081 NA 0.002 1.3e-08 NA 3.8e-07 NA 2.2e-01
2 GTEx Artery Aorta 0.2080 0.0600 1.7e-05 0.069 NA 0.158 NA 0.073 1.2e-04 NA 4.8e-09 NA 7.3e-05
3 GTEx Artery Tibial 0.1363 0.0448 2.3e-05 0.095 NA 0.071 NA 0.000 7.4e-08 NA 3.0e-06 NA 3.2e-01
4 GTEx Brain Nucleus accumbens basal ganglia 0.1720 0.0730 5.4e-03 -0.007 NA -0.010 NA -0.005 5.5e-01 NA 7.1e-01 NA 4.6e-01
5 GTEx Breast Mammary Tissue (Male) 0.1831 0.0898 3.0e-02 -0.012 NA 0.023 NA 0.011 7.5e-01 NA 9.6e-02 NA 1.8e-01
6 GTEx Cells EBV-transformed lymphocytes 0.2920 0.0830 3.6e-05 0.091 NA 0.176 NA 0.192 7.0e-04 NA 2.2e-06 NA 7.1e-07
7 GTEx Esophagus Mucosa 0.2180 0.0720 5.2e-04 0.011 NA 0.020 NA 0.013 5.7e-02 NA 1.6e-02 NA 4.0e-02
8 GTEx Nerve Tibial 0.0935 0.0356 1.3e-03 0.064 NA 0.014 NA 0.040 2.5e-05 NA 3.3e-02 NA 7.7e-04
9 GTEx Pancreas 0.1950 0.0650 1.4e-04 0.234 NA 0.248 NA 0.231 2.9e-10 NA 7.0e-11 NA 3.9e-10
10 GTEx Skin Sun Exposed Lower leg 0.0890 0.0390 3.6e-03 0.044 NA 0.016 NA 0.003 1.5e-04 NA 1.5e-02 NA 1.8e-01
11 GTEx Thyroid 0.1020 0.0380 1.3e-04 0.048 NA 0.037 NA 0.013 1.5e-04 NA 8.1e-04 NA 3.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.3 0.4 1.5 0.7 0.4 -0.2 -0.2 1.0 0.5 0.7 1.2 0.3 0.5 0.5
Bipolar Disorder or Schizophrenia 0.4 1.0 6.1 0.3 0.7 -1.5 -2.5 0.1 1.1 0.4 -0.1 -0.3 -0.4 -0.7
Depressed Affect (Nagel 2018) 1.0 2.1 8.2 -1.3 -2.0 -0.6 0.5 -0.4 0.7 -2.5 -2.9 -1.2 -0.3 -0.5
Depression (Nagel 2018) 0.9 1.3 6.0 0.4 0.3 -1.0 -1.8 -0.1 2.5 0.1 -1.9 -0.4 0.0 -0.4
Intelligence (Savage-Jansen 2018) 1.9 5.9 10.0 -2.9 -1.3 -3.2 -2.3 -3.0 2.2 0.3 -2.1 -2.6 -2.6 -2.7
Neuroticism (Nagel 2018) 1.0 2.3 8.1 -1.4 -1.4 -1.2 -1.0 -1.3 2.0 -1.5 -2.8 -1.3 -0.0 -1.1
Schizophrenia (2018) 0.8 1.7 9.0 -0.3 0.6 -1.8 -3.0 -0.8 1.0 -0.2 -1.2 -0.7 -1.1 -1.3
Schizophrenia vs Biploar Disorder 0.7 1.0 3.3 -0.6 -0.8 -1.1 -1.1 -1.8 0.2 0.1 -1.1 -0.8 -1.2 -0.8
Worry (Nagel 2018) 1.1 2.2 6.7 -0.7 -0.8 -1.3 -2.1 -1.2 2.6 -0.6 -2.1 -1.1 -0.4 -1.7
Alzheimer’s Disease (in mother) 0.9 1.0 2.8 0.7 1.4 0.6 -0.7 0.6 0.3 1.5 -0.4 1.7 1.3 0.7
Alzheimer’s Disease (in father) 1.1 1.2 4.7 0.8 1.4 0.5 -1.3 0.9 1.0 2.2 0.1 0.8 1.3 0.2
Alzheimer’s Disease (including proxy) 1.3 1.8 8.2 1.0 1.7 0.4 -1.8 0.4 1.2 2.9 -0.3 1.0 1.3 0.2
Crohns Disease (2017) 0.5 1.0 4.3 -0.8 0.5 -0.4 -2.1 -0.6 2.1 0.7 -0.6 -0.6 -0.3 -0.3
Irritable Bowel Disease (IBD) 0.4 0.9 4.7 -0.1 0.9 0.1 -2.2 -0.1 2.0 0.8 -0.4 -0.3 0.2 -0.0
Ulcerative Colitis (UC) 0.3 0.6 3.0 0.1 0.7 0.3 -1.7 0.1 1.6 0.4 -0.7 -0.1 0.4 0.0
Major Depression (MDD) 4.5 5.4 17.2 -0.8 -0.4 -3.4 -3.4 -1.0 4.2 -1.7 -2.0 -1.8 -1.0 -2.5
Reaction Time 0.8 1.5 8.5 -0.5 -0.7 0.7 1.9 0.5 -2.9 0.5 1.4 0.2 -0.1 0.8
Verbal and Numeric Reasoning (VNR) 1.1 2.7 10.6 -1.6 0.0 -1.8 -1.7 -3.2 1.5 -0.2 -1.2 -1.2 -2.0 -0.9
Breast Cancer 0.5 1.1 3.5 1.0 1.1 0.8 -0.3 1.4 0.9 1.9 1.0 0.8 1.1 0.8
Ovarian Cancer 0.5 0.6 1.7 -0.6 1.3 -0.5 -1.2 -0.9 0.6 0.2 -1.1 0.1 -0.1 -0.7
Prostate Cancer 1.9 2.7 6.3 -1.4 0.4 -1.7 -2.4 -0.8 2.5 -1.2 -2.5 -0.6 -0.7 -1.9
Age at First Birth 1.3 1.9 3.8 -1.2 -0.2 -1.4 -2.0 -0.9 1.6 0.4 -1.4 -1.8 -1.1 -1.9
Bipolar Disorder (2011) 0.2 0.2 0.7 0.8 0.2 0.1 0.4 0.5 -0.6 -0.1 0.0 0.4 0.8 0.4
Body Mass Index (BMI) (2010) 0.9 1.3 2.4 1.2 0.0 1.0 1.5 0.9 -1.5 1.1 1.3 1.1 0.6 1.2
Coronary Artery Disease (CAD) 0.1 0.1 0.4 0.4 -0.1 -0.3 -0.5 -0.6 0.3 0.1 -0.1 -0.1 -0.1 0.1
Crohns Disease (2012) 0.3 0.4 2.2 -0.5 0.9 -0.1 -1.0 -0.2 0.6 1.5 0.0 0.2 -0.1 0.1
Mean Putamen Volume 0.8 1.0 4.7 0.2 0.6 -0.1 -1.2 0.6 2.2 0.6 -1.5 0.5 0.7 0.6
Fasting Glucose 0.6 0.7 2.4 -0.6 -1.2 -0.4 0.3 -0.9 -1.0 -1.2 -1.6 -0.4 -0.1 -0.4
HbA1C 0.7 0.8 2.5 0.9 0.6 1.1 -0.6 0.7 1.0 1.6 1.0 0.5 0.5 0.5
HDL Cholesterol 0.2 0.4 1.2 0.4 0.5 -0.7 -1.0 -0.6 -0.1 0.4 -0.5 -0.0 -0.6 -1.1
LDL Cholesterol 0.2 0.4 1.0 -0.8 -1.0 0.2 0.7 0.4 -0.7 0.6 0.5 -0.7 0.0 0.3
Lupus 1.2 1.8 4.0 -2.0 -1.6 -1.1 -0.3 -1.4 1.2 -1.1 -0.7 -2.0 -1.2 -1.0
Neuroticism (2016) 0.5 0.7 2.4 0.2 1.3 0.2 -1.0 -0.5 1.5 0.6 -0.4 0.2 1.5 0.1
Primary Biliary Cirrhosis 0.6 0.8 2.3 0.5 -0.5 0.0 0.9 -1.4 -1.5 -1.4 0.9 0.3 -0.5 -0.1
Rheumatoid Arthritis 1.0 1.3 2.9 1.3 0.8 1.2 1.2 0.6 -1.1 -0.4 1.7 1.0 1.1 1.5
Schizophrenia (2014) 1.0 2.1 11.4 -0.2 1.0 -1.7 -3.4 -0.9 1.5 0.5 -0.7 -1.0 -0.7 -1.6
Triglycerides 0.2 0.3 1.4 0.3 0.7 0.1 -0.1 0.2 0.2 0.5 0.3 0.4 1.2 0.4
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.1 0.2 -0.2 0.0 -0.2 1.1 0.2 -0.1 -0.9 0.7 -0.1 0.0
Ulcerative Colitis 0.8 1.1 3.9 1.3 0.8 1.3 -0.2 0.7 0.4 2.0 0.4 0.6 1.6 0.8
Blood Eosinophil Count 1.1 8.6 15.5 -3.6 -0.0 -2.5 -3.8 -3.9 3.5 -1.1 -2.1 -2.8 -2.7 -3.6
Blood Platelet Count 0.4 4.5 18.2 -0.1 3.7 -0.7 -4.3 -2.7 1.2 -0.4 -1.2 1.1 -1.6 -1.8
Blood Red Count 1.3 12.8 27.9 1.6 -2.6 3.4 5.0 4.0 -3.4 3.4 5.3 0.9 2.0 4.8
Blood White Count 0.3 2.1 7.9 -0.8 2.3 -0.1 -2.5 -1.7 0.6 2.8 0.6 -0.2 -0.1 -0.3
Heel T-Score 3.3 26.1 68.7 -3.9 1.0 -5.7 -8.3 -4.2 7.5 1.3 -5.4 -4.2 -2.0 -6.5
BMI 0.2 1.4 6.0 -1.4 -1.1 0.6 1.4 -0.4 -2.4 -0.6 -1.4 0.3 -1.1 0.2
Height 2.5 47.4 86.3 8.4 6.7 8.2 4.2 8.4 -1.2 4.0 7.1 5.9 9.3 7.7
Waist Hip Ratio (WHR) 1.4 6.5 14.2 2.2 1.1 3.2 3.3 1.5 -0.8 2.3 3.8 1.8 3.3 2.8
Systolic Blood Pressure 0.1 0.5 1.5 -0.4 -0.3 -1.1 -1.0 -1.2 -0.3 1.0 -0.1 -0.7 0.2 -0.6
Smoking Status 0.4 0.9 2.3 0.8 1.3 -0.0 -0.5 0.6 1.4 1.1 0.3 0.7 1.5 1.0
Allergy or Eczema 0.9 2.3 6.4 1.3 2.4 0.3 -2.5 -0.1 1.9 1.8 0.1 1.3 1.6 0.5
Cardiovascular Disease 0.2 0.6 3.2 0.3 -1.0 0.6 0.6 0.2 -1.8 -0.2 -0.2 0.8 -0.3 1.1
Hypothyroidism (self reported) 1.3 3.1 9.1 1.6 0.2 2.0 3.0 1.1 -2.0 -1.0 2.0 1.5 1.1 2.2
Respiratory disease 1.5 3.3 12.4 -1.4 1.4 -1.2 -3.5 -0.2 3.3 -0.4 -2.1 -0.7 -0.9 -1.3
Type 2 Diabetes (T2D) (2018) 1.9 3.5 10.0 -0.0 1.7 2.6 1.5 1.6 -1.1 2.2 2.1 0.9 1.7 3.2
Lung FEV1/FVC ratio 0.0 0.2 0.9 -0.6 -0.5 -0.5 0.9 -0.4 0.6 -0.1 0.1 0.3 0.5 -0.4
Lung FVC 0.0 0.2 1.3 0.1 -0.0 -0.2 -0.1 0.4 -0.4 1.1 0.2 0.6 0.4 0.3
Neuroticism 0.8 2.0 8.2 -0.5 -0.7 -0.9 -1.5 -0.9 2.4 -1.5 -2.9 -0.9 0.2 -0.5
Chronotype (morning person) 2.3 5.3 15.7 1.4 -0.1 2.6 4.0 2.3 -3.3 1.3 2.0 1.8 1.0 2.9
Hair Pigment 0.1 4.1 8.2 -2.1 -1.2 -2.3 -1.8 -2.5 0.4 -2.1 -1.6 -1.7 -2.5 -2.9
Tanning 0.0 0.3 1.2 -0.0 0.6 -0.0 -1.0 -0.1 0.5 1.1 0.7 -0.2 -0.3 -0.2
Hand grip strength (left) 0.4 1.0 6.3 -0.8 -1.0 -0.7 -0.2 -0.1 1.2 2.5 0.2 -1.2 0.1 0.3
Number of treatments/medications taken 0.6 1.0 3.6 -1.3 -1.0 -0.9 -0.8 0.5 1.9 0.3 -1.1 -0.6 -0.6 -1.0
Average weekly spirits intake 1.7 2.1 4.8 1.1 1.7 2.0 0.3 0.8 -1.2 1.4 1.5 2.2 1.6 1.2
Sensitivity / hurt feelings 0.3 0.6 2.8 0.1 0.6 1.0 -0.3 -0.3 0.4 -0.6 -0.4 0.3 1.7 1.0
Frequency of depressed mood in last 2 weeks 1.9 2.6 7.6 -1.4 0.4 -1.6 -2.0 -1.1 2.5 -1.1 -2.8 -1.5 -0.5 -1.2
Hearing difficulty/problems: Yes 2.1 3.2 8.9 2.5 1.7 2.4 0.9 1.1 -1.0 1.1 1.3 1.9 3.0 1.5
Relative age of first facial hair 0.7 1.4 3.2 -0.7 -1.8 -1.7 -0.4 -0.4 1.3 -0.5 -1.4 -0.9 -1.5 -1.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.9 -0.0 -1.4 0.8 1.7 0.3 -1.6 -0.6 0.3 0.2 -0.2 0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.0 1.0 0.4 0.3 -0.0 -0.3 0.5 -0.3 0.2 1.0 0.6 -0.2
Ever had hysterectomy (womb removed) 0.8 0.9 2.3 1.1 1.5 0.7 -1.3 0.3 1.4 1.1 -0.2 1.0 0.4 0.2
Systolic blood pressure, automated reading 0.1 0.3 1.3 -0.0 0.1 -0.0 -0.3 -0.9 -0.9 1.1 -0.3 0.6 0.4 0.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 4.5 -0.8 -0.8 0.4 1.4 0.4 -1.8 2.1 0.9 0.3 0.2 0.9
Angina 0.2 0.3 1.2 0.3 -0.3 -0.1 -0.9 -0.7 1.1 -0.4 -0.4 -0.3 -0.5 -0.4
Medication for hormone replacement therapy 0.1 0.1 0.4 0.5 0.4 0.7 -0.1 -0.1 0.6 -0.5 -0.2 0.1 0.2 -0.2
Vitamin and mineral supplements 0.6 0.9 3.2 1.2 -0.4 0.6 1.3 -0.2 -1.8 -1.2 0.1 1.0 0.0 0.5
Supplements: Zinc 0.5 0.5 3.1 -0.4 0.5 -0.6 -1.2 0.2 1.8 -0.1 -0.4 -0.4 0.3 -0.2
Medication: Co-codamol 0.9 1.0 5.4 -0.7 2.3 0.8 -1.4 -0.1 0.6 1.1 0.8 -0.6 0.4 -0.3
Medication: Metformin 2.0 2.8 8.5 0.4 1.6 1.7 0.4 1.9 -0.5 2.9 1.8 1.3 1.9 2.1
Diabetes (father) 2.9 3.6 11.5 0.8 2.7 2.0 0.9 1.6 0.3 1.6 3.4 0.9 2.3 1.8
Diabetes (mother) 0.5 0.6 2.9 -0.6 -0.6 0.0 -0.2 0.4 0.9 -1.7 -1.3 -0.4 -0.3 0.2
Severe depression (siblings) 1.9 2.1 6.7 -0.7 -0.0 -1.5 -2.6 -1.4 2.2 -0.4 -1.4 -1.3 -1.0 -1.5
Pack years adult smoking proportion 0.4 0.6 3.8 -0.6 0.3 0.1 -0.8 0.7 1.9 0.6 -0.1 -0.2 0.5 0.2
Impedance of leg (right) 0.3 1.6 3.6 -1.3 -0.7 -1.0 -0.5 -1.6 0.3 -1.9 -0.2 -1.7 -1.8 -1.1
Leg fat-free mass (left) 1.3 6.9 12.8 2.1 1.4 3.6 3.1 2.5 -3.1 0.8 2.5 2.4 2.8 3.3
Trunk fat percentage 0.6 2.4 13.5 -0.8 -0.3 1.9 2.3 -0.1 -3.7 -1.2 -0.2 0.6 -0.8 0.8
Hand grip strength (right) 0.2 0.6 3.8 -0.3 -0.3 0.0 -0.0 0.7 0.6 2.0 1.2 -0.5 0.5 0.4
Townsend deprivation index at recruitment 0.1 0.1 0.7 0.0 -0.3 0.0 0.4 -0.8 -0.4 -0.5 0.3 0.3 -0.1 0.0
Current tobacco smoking 0.5 0.8 2.7 0.4 1.6 0.4 -0.2 0.5 0.8 1.0 0.4 0.4 1.2 1.7
Average weekly fortified wine intake 0.5 0.6 3.7 -1.2 0.1 -0.5 -0.1 -1.9 -0.9 0.2 0.2 -0.5 -0.2 -0.5
Maternal smoking around birth 1.7 2.4 5.7 1.5 1.0 1.6 0.7 2.4 0.3 0.5 0.8 2.0 2.1 2.4
Fed-up feelings 0.4 0.7 5.3 -1.3 0.2 -0.0 -0.1 0.0 0.7 -0.6 -2.3 -0.6 0.1 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 6.8 -0.6 0.5 -1.1 -2.1 -0.1 2.6 -0.3 -2.5 -1.1 -0.5 -1.0
Relative age voice broke 0.5 0.8 2.1 0.7 1.2 0.6 -0.6 1.3 0.7 0.4 -0.5 1.3 1.5 0.4
Taking other prescription medications 1.2 1.8 7.8 -1.5 -0.5 -1.0 -1.0 -1.3 2.8 -0.2 -0.7 -1.8 -0.6 -1.3
Age when periods started (menarche) 0.7 1.8 5.7 -0.4 -0.5 -1.2 -1.3 -1.0 0.2 -1.9 -2.4 -0.3 -2.2 -1.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.2 0.5 -0.2 -0.9 -1.3 -1.1 0.7 -0.2 -1.5 -0.1 -0.9 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 6.6 -1.4 0.7 -1.6 -2.4 -0.6 2.6 0.4 -1.0 -1.2 -0.7 -1.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.7 0.6 -0.1 0.3 0.4 -0.2 -0.8 -0.6 -0.8 0.4 -0.3 0.4
Qualifications: CSEs or equivalent 0.5 0.7 3.4 0.5 0.7 1.3 0.4 1.9 0.1 0.3 0.0 -0.1 0.7 0.9
Serious illness, injury or assault to yourself 0.7 0.9 4.0 -0.6 -0.9 0.1 1.3 0.0 -1.4 -2.0 -0.5 0.0 -0.7 -0.0
High blood pressure 0.4 1.2 4.6 -1.7 -2.2 -0.7 0.0 -1.4 -0.5 -0.3 -0.8 -0.9 -1.0 -0.7
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.3 0.6 1.7 0.2 -1.8 0.0 1.4 1.3 0.2 0.5 1.1 0.0
Multivitamins +/- minerals 0.4 0.6 1.7 -0.9 -0.0 -0.6 -0.6 0.7 1.0 1.3 -0.1 -1.0 -0.2 -0.5
Stomach or abdominal pain in last month 0.4 0.5 1.0 0.7 0.1 0.9 0.2 0.7 -0.1 0.9 0.4 1.0 0.8 0.7
Supplements: Glucosamine 0.3 0.4 2.8 -0.0 -0.5 0.0 0.4 0.9 -0.1 1.7 0.4 0.6 0.6 0.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.3 -0.1 -0.1 0.2 0.0 -0.7 0.8 -1.1 -0.2 0.2 0.2 0.1
Medication: Atenolol 0.4 0.6 2.6 -0.3 -1.6 -0.5 1.1 0.3 -0.4 0.9 0.2 -0.7 -0.3 0.1
Medication: Levothyroxine sodium 1.5 2.6 6.7 1.6 0.2 2.1 2.6 0.1 -1.6 -1.9 1.4 1.2 1.2 2.0
Sitting height 1.5 10.9 19.1 3.8 2.9 4.4 2.5 2.3 -3.1 1.4 4.1 2.7 3.7 4.1
Chronic bronchitis/emphysema (father) 0.6 0.7 2.8 0.3 -0.4 -0.5 -1.2 0.2 1.3 -1.7 0.1 -0.6 -0.6 -0.6
High blood pressure (mother) 0.2 0.3 1.3 0.6 -0.1 0.8 -0.4 1.1 0.2 -0.2 -0.3 0.8 0.5 0.2
Body mass index (BMI) 0.3 1.2 5.4 -0.8 -0.9 1.2 1.7 0.1 -2.3 -0.3 -0.9 0.7 -0.8 0.7
Impedance of leg (left) 0.2 1.2 3.8 -1.1 -0.6 -0.9 -0.3 -1.3 0.1 -1.9 -0.1 -1.4 -1.6 -1.0
Leg predicted mass (left) 1.3 6.8 13.0 2.2 1.4 3.6 3.1 2.5 -3.0 0.9 2.5 2.3 2.7 3.2
Trunk fat mass 0.7 3.0 12.9 0.1 0.1 2.6 2.8 0.8 -3.6 -0.6 0.5 1.2 0.2 1.6
Waist circumference 0.9 3.3 9.2 1.1 0.3 3.0 2.9 1.3 -2.3 0.1 0.7 1.8 1.1 2.2
Number of incorrect matches in round 0.2 0.3 0.9 -0.5 0.5 0.4 -0.2 -1.0 0.6 -0.2 0.0 -0.5 0.7 -0.0
Past tobacco smoking 0.6 1.2 3.0 -1.1 -1.5 -0.1 0.6 -1.3 -1.7 -0.9 -0.4 -1.0 -1.4 -0.3
Alcohol usually taken with meals 0.1 0.2 0.8 0.4 -0.2 -0.9 -0.3 0.0 -0.3 0.8 -0.1 -0.3 -0.4 -0.7
Nervous feelings 1.7 3.2 7.5 -1.5 -1.3 -1.9 -2.4 -1.3 2.1 1.6 -2.7 -1.5 -1.0 -1.7
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 6.9 -1.4 -0.6 -1.4 -1.0 -1.2 2.1 -1.1 -2.6 -1.5 -0.6 -0.9
Hearing difficulty/problems with background noise 1.3 2.0 4.8 -1.2 0.8 -1.4 -1.9 -1.9 1.7 -0.7 -0.7 -1.5 -0.7 -2.2
Hair/balding pattern: Pattern 2 0.6 0.7 2.7 0.1 -0.4 0.8 0.9 0.4 -1.4 1.1 0.5 0.4 -0.2 1.6
Had menopause 3.3 4.2 8.5 2.2 2.0 2.6 1.7 0.8 -1.2 0.9 1.9 2.6 2.3 2.9
Had other major operations 0.7 0.9 2.1 0.8 0.7 1.0 0.3 0.5 0.5 1.4 0.5 1.3 1.5 0.9
Forced vital capacity (FVC) 1.4 5.4 9.7 2.7 2.5 2.7 1.5 2.0 -1.4 0.9 2.4 2.7 3.1 2.7
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.2 8.5 -2.5 0.1 -2.6 -2.9 -1.3 2.1 1.5 -1.4 -2.4 -1.5 -2.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.4 -0.3 -1.2 -0.9 -0.8 -0.2 1.0 -0.9 -1.2 -0.9 0.0 -1.0
Qualifications: None of the above 3.7 7.9 17.5 2.2 1.7 4.2 3.7 1.7 -1.7 1.1 3.1 2.5 3.1 3.9
Financial difficulties in last 2 years 0.4 0.5 2.2 -1.0 -0.8 -0.4 -0.1 0.1 0.5 -0.8 -1.5 -0.3 -1.0 -0.3
Mouth/teeth dental problems 0.5 0.8 3.1 0.6 -0.4 1.0 1.8 -0.5 -1.6 -0.6 -0.1 0.7 0.6 0.8
Heart attack 0.1 0.1 0.2 -0.0 0.1 0.1 0.1 -0.5 0.0 -0.3 -0.3 -0.2 -0.5 -0.4
Allergy 0.7 1.6 7.5 0.5 -1.0 0.7 2.7 -0.2 -2.7 -0.1 0.8 0.2 0.1 0.9
Pain all over the body in last month 1.2 1.2 6.1 -0.4 -0.4 0.6 2.0 -0.1 -2.5 -0.4 1.2 0.3 0.3 1.1
Diabetes (self-reported) 1.1 1.7 7.5 -0.4 0.5 1.7 0.9 1.1 -0.2 2.7 0.6 0.4 0.9 2.2
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 5.0 -0.7 1.6 -1.4 -2.2 -0.8 1.8 0.4 -1.2 -0.1 -0.3 -1.0
Medication: Ramipril 1.7 2.2 4.5 1.3 0.6 1.4 1.1 2.0 -0.3 2.1 1.0 1.1 1.9 2.1
Medication: Simvastatin 0.6 1.0 3.4 0.7 1.2 0.4 -1.2 1.4 1.9 0.1 -0.9 0.4 0.7 0.3
Fluid intelligence score 1.1 2.2 4.6 -1.5 -0.9 -2.1 -1.6 -1.3 1.3 0.2 -2.1 -1.3 -1.6 -1.2
Illnesses of siblings 0.6 0.9 3.8 -0.4 -0.1 -1.2 -1.1 0.7 1.9 -0.1 -0.8 -0.9 -0.2 -1.0
Neuroticism score 1.0 2.2 8.5 -1.1 -0.0 -0.9 -1.7 -1.0 2.6 -0.4 -2.9 -1.3 0.2 -0.9
Weight 1.1 5.6 12.7 1.6 1.1 3.6 3.2 2.0 -3.2 0.5 1.6 2.3 1.8 3.0
Impedance of arm (right) 0.1 0.5 1.7 -0.8 0.5 -0.3 -0.7 -0.4 -0.5 -1.1 -0.2 -1.3 -0.6 -0.5
Arm fat percentage (right) 0.5 1.9 10.9 -0.9 -0.5 1.6 1.8 0.1 -3.3 -0.8 -0.8 0.5 -0.9 0.8
Trunk fat-free mass 1.5 8.5 13.8 3.4 2.0 3.6 2.8 3.1 -1.5 1.4 2.9 2.9 3.7 3.5
Hip circumference 0.5 2.3 7.3 0.6 0.5 2.5 1.9 1.2 -2.7 -0.9 -0.2 1.5 0.5 1.6
Time employed in main current job 1.1 1.2 3.7 -0.4 -0.7 -1.5 -1.9 -0.6 1.3 0.9 -1.1 -0.9 -0.7 -1.2
Alcohol intake versus 10 years previously 0.8 1.2 2.9 0.5 1.1 1.0 1.0 0.4 -1.2 1.1 0.8 1.0 1.6 1.7
Father’s age at death 1.3 1.7 5.7 0.1 1.5 -0.6 -2.3 1.4 2.4 1.5 -0.7 0.2 -0.2 -0.8
Worrier / anxious feelings 1.3 2.4 6.1 -1.1 -1.5 -1.4 -1.4 -1.4 2.5 -0.7 -2.4 -1.9 -0.6 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.2 -0.8 0.9 -0.2 -1.0 -0.1 1.1 -0.1 -0.9 -0.6 -0.4 -0.2
Falls in the last year 0.1 0.1 0.5 0.4 0.4 0.1 -0.5 0.0 -0.2 0.4 0.2 -0.1 -0.7 -0.3
Hair/balding pattern: Pattern 3 0.4 0.6 2.0 -0.4 0.8 0.1 0.7 -0.7 -0.5 1.4 0.7 0.2 1.4 0.3
Number of live births 0.7 1.0 2.6 0.9 0.7 1.3 1.1 0.5 0.6 0.0 1.6 0.7 1.3 1.4
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 6.3 2.0 1.8 2.0 1.7 1.1 -1.5 0.5 2.1 2.1 2.5 2.0
Pulse rate 1.1 1.9 4.7 -1.8 -1.2 -1.0 -0.9 -1.1 0.9 -1.5 -1.4 -2.2 -1.4 -1.1
Happiness 1.7 2.1 6.4 -0.5 -0.5 -1.6 -2.5 -0.2 2.4 0.7 -2.0 -1.2 -0.6 -1.1
Noisy workplace 0.2 0.2 1.5 0.1 0.1 0.8 -0.4 -0.2 1.2 -0.1 0.0 -0.1 0.0 -0.1
Qualifications: A levels/AS levels or equivalent 2.2 4.9 10.1 -1.6 -1.0 -2.9 -3.2 -2.1 2.0 -1.0 -2.8 -2.1 -2.3 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 1.1 -0.2 0.4 -0.3 -0.2 -0.0 0.0 -1.1 -0.1 0.3 0.6 0.1
Mouth/teeth dental problems: Dentures 1.2 2.0 5.3 1.1 2.0 1.1 -1.4 1.3 2.3 1.1 1.9 0.8 0.9 0.9
Asthma 2.1 4.1 9.6 -2.2 -0.2 -2.1 -3.1 -0.4 2.9 -1.4 -1.9 -1.7 -1.7 -2.5
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.1 -0.7 0.2 -0.9 -1.9 -0.3 1.7 2.0 0.4 -0.9 -0.5 -1.5
Medication: Cholesterol lowering 0.3 0.5 2.7 0.4 -0.6 -0.2 -0.2 1.6 1.3 -0.4 -0.7 0.4 0.3 0.4
Depression (self-reported) 1.2 1.5 5.5 0.4 1.1 -0.8 -2.3 0.1 2.1 -0.3 -1.8 0.4 0.2 -1.0
Medication: Lansoprazole 1.6 1.9 5.8 -1.2 0.8 -0.5 -2.4 -1.4 1.8 -0.6 -1.5 -0.8 -1.6 -0.8
Prospective memory result 1.6 2.0 4.4 -2.1 -1.8 -1.0 -0.3 -1.7 0.6 -1.8 -1.3 -1.5 -1.1 -1.2
Lung cancer (father) 0.7 0.9 2.3 -1.3 -1.2 -0.5 1.1 -0.5 -1.5 0.2 -0.5 -1.1 -0.7 -0.3
Illnesses of mother 0.4 0.5 1.3 -0.0 -0.8 -0.4 1.0 -0.2 -0.8 0.1 0.6 -1.2 -0.9 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 4.0 1.3 1.0 1.9 2.0 0.9 -2.0 -0.5 1.4 1.7 1.9 1.8
Pulse wave Arterial Stiffness index 0.4 0.5 1.4 0.3 0.7 0.4 0.1 0.6 1.2 1.2 0.4 -0.0 1.0 0.2
Impedance of arm (left) 0.1 0.6 2.2 -0.9 0.4 -0.3 -0.6 -0.5 -0.6 -1.3 0.2 -1.5 -0.8 -0.6
Arm fat mass (right) 0.7 3.0 12.4 0.3 -0.0 2.6 2.8 0.9 -3.5 -0.3 0.5 1.3 0.2 1.9
Trunk predicted mass 1.5 8.3 13.4 3.3 2.0 3.6 2.8 3.1 -1.6 1.3 2.9 2.9 3.7 3.5
Standing height 2.1 21.3 35.7 5.2 4.2 5.7 3.9 4.4 -2.5 1.8 5.8 3.6 6.0 5.5
Length of working week for main job 0.3 0.4 1.0 0.4 0.9 0.2 -1.0 0.2 -0.7 0.9 0.9 -0.3 0.1 -0.0
Exposure to tobacco smoke at home 0.4 0.4 1.9 0.5 0.7 0.5 -0.0 0.4 0.8 -0.8 0.1 0.3 1.4 0.5
Breastfed as a baby 1.1 1.3 2.4 -0.6 -1.2 -1.1 -1.4 -0.3 1.5 -0.7 -1.4 -0.7 -1.4 -1.4
Tense / ‘highly strung’ 0.6 1.0 3.3 -0.1 1.8 -0.1 -1.8 -0.4 1.4 0.5 -0.5 0.0 0.9 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 7.0 -0.4 1.7 -0.8 -2.6 -1.2 2.0 1.1 -1.1 -0.3 0.0 -0.8
Hair/balding pattern: Pattern 4 0.4 1.0 7.4 0.6 -0.2 0.6 -0.4 2.7 0.8 0.9 -0.3 0.5 0.7 -0.3
Birth weight of first child 1.5 2.7 7.6 2.8 2.5 1.8 0.0 0.9 -0.9 0.3 1.1 2.5 1.8 0.6
Peak expiratory flow (PEF) 0.2 0.5 1.9 0.2 0.4 0.3 1.4 1.1 -0.1 0.2 1.0 0.2 0.7 0.8
Pulse wave reflection index 1.7 2.1 6.6 1.5 1.3 0.7 0.4 1.9 1.1 2.6 1.0 1.1 1.9 1.0
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.9 -0.2 -0.2 0.1 -0.1 1.0 0.6 0.3 -0.6 -0.5 -0.1 0.3
Loud music exposure frequency 0.5 0.6 1.1 1.0 0.4 0.0 -0.8 1.0 0.9 0.7 -1.0 0.9 0.5 0.3
Qualifications: O levels/GCSEs or equivalent 1.5 2.3 7.8 -0.7 -1.9 -1.8 -0.4 -1.5 -0.7 -1.8 -1.1 -1.2 -2.8 -1.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 5.1 -1.3 -1.8 -2.3 -0.8 0.1 -0.7 0.5 -1.7 -1.3 -1.9 -1.9
Blood clot in the leg (DVT) 0.3 0.4 1.3 -0.7 -0.8 -0.9 -0.0 -0.5 -0.0 -0.5 -0.1 -0.9 -1.1 -0.3
Medication: Paracetamol 1.6 2.6 4.7 -1.5 -0.5 -1.9 -1.5 -2.2 1.3 -0.9 -1.8 -0.7 -2.1 -2.1
Headache pain in last month 1.4 2.4 5.4 -1.6 -1.0 -1.6 -2.1 -0.7 1.8 0.2 -2.3 -1.4 -1.1 -1.7
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.6 -0.5 1.0 -0.5 -1.4 -1.9 0.7 0.3 0.0 -0.8 -0.7 -1.1
Glaucoma (self-reported) 1.0 1.1 3.4 1.6 0.1 0.2 -0.7 1.2 1.0 1.8 0.0 0.7 1.4 1.2
Gout (self-reported) 0.2 0.3 1.3 -0.3 -0.5 0.2 1.1 0.3 -0.2 -0.9 0.7 0.0 0.3 -0.5
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 8.8 1.3 -0.3 1.8 3.0 0.6 -2.0 -0.9 1.4 1.2 0.9 2.1
Medication: Amlodipine 0.8 1.1 3.4 1.4 1.1 0.6 0.2 1.8 0.2 0.3 -0.1 1.1 1.5 1.2
Medication: Ventolin 100micrograms inhaler 1.3 1.7 5.6 0.9 2.4 1.2 -0.6 2.3 0.4 -0.5 0.3 1.3 1.1 1.3
Birth weight 1.6 3.5 9.5 -1.3 -1.3 -2.6 -2.2 -2.3 1.0 0.2 -1.8 -1.8 -1.4 -3.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 4.0 -0.1 0.9 -0.2 -1.0 0.3 2.0 0.9 -0.2 0.3 0.3 0.3
High blood pressure (siblings) 0.5 0.8 3.9 -0.6 -1.4 0.0 0.3 -1.1 -2.0 -0.2 -0.2 0.3 -0.5 -0.6
Forced vital capacity (FVC), Best measure 0.9 3.4 5.8 1.7 1.4 2.4 1.8 1.7 -1.8 0.0 1.5 2.1 2.2 2.4
Body fat percentage 0.7 2.8 15.1 -0.8 -0.8 1.9 2.6 -0.2 -3.9 -1.2 -0.3 0.6 -1.1 0.9
Leg fat percentage (right) 0.7 2.5 10.1 -1.2 -1.6 1.3 2.4 -0.6 -3.2 -1.1 -0.8 0.2 -1.7 0.7
Arm fat-free mass (right) 1.4 7.2 12.5 2.6 1.4 3.5 3.2 2.3 -2.4 1.3 3.1 2.6 2.8 3.2
Exposure to tobacco smoke outside home 0.6 0.7 3.5 0.1 -1.8 0.0 0.6 -0.3 -0.2 -1.9 -0.7 0.1 -0.7 0.3
Comparative body size at age 10 0.3 0.8 2.4 1.0 0.3 0.5 0.2 1.5 1.1 -0.8 -0.1 1.0 1.1 1.3
Number of full brothers 1.1 1.4 3.5 1.2 0.7 1.0 1.3 1.9 -1.0 0.5 0.6 1.5 1.4 1.1
Worry too long after embarrassment 1.4 2.4 7.4 -1.3 0.1 -1.5 -1.8 -1.1 2.7 -1.2 -2.2 -1.6 -0.2 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 1.4 -0.2 -0.4 -0.1 0.4 -0.0 0.4 -1.2 -0.6 -0.2 0.3 -0.2
Wheeze or whistling in the chest in last year 1.2 2.1 7.4 -1.4 1.3 -1.2 -2.7 -0.7 2.1 -0.4 -1.1 -0.8 -1.4 -1.1
Number of children fathered 2.2 2.4 4.5 1.9 0.6 2.1 1.5 2.0 -0.8 0.2 1.5 2.1 1.7 1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 4.4 -1.0 -2.1 -2.0 -0.3 -0.7 0.3 -0.7 -1.4 -0.8 -1.7 -1.3
Age at first live birth 3.8 6.8 13.9 -2.6 -2.3 -2.9 -1.8 -2.3 1.1 -2.2 -3.7 -3.1 -2.6 -3.1
Pulse wave peak to peak time 0.4 0.4 2.5 0.1 -0.6 0.0 0.3 -0.2 -1.6 -1.2 0.0 0.3 -0.6 0.2
Health satisfaction 0.2 0.3 1.5 -0.1 -0.4 0.3 0.3 -0.7 -0.5 1.2 -0.3 -0.5 -0.4 0.4
Shortness of breath walking on level ground 0.2 0.3 1.6 -0.5 1.2 -0.1 -0.6 -0.2 -0.1 0.5 -0.2 -0.2 -0.2 0.6
Qualifications: College or University degree 2.9 9.1 20.2 -1.8 -2.3 -4.5 -3.9 -2.3 3.0 0.3 -3.9 -2.8 -3.1 -3.1
Eye problems/disorders: None of the above 2.7 3.1 8.6 -2.2 -0.3 -1.9 -1.0 -2.6 1.0 -0.8 -0.5 -2.4 -1.5 -2.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.5 -0.6 -0.6 -0.1 -0.1 -0.1 -0.7 -0.5 0.3 -0.7 -0.3 -0.4
Emphysema/chronic bronchitis 0.3 0.3 2.0 -0.5 0.1 -0.3 -0.6 0.1 1.4 0.8 -0.3 -0.3 0.4 0.4
Medication for pain relief, constipation, heartburn 0.3 0.6 1.7 0.2 -0.2 0.6 1.3 0.8 -1.1 -0.1 -0.0 0.2 1.0 1.1
Neck or shoulder pain in last month 0.6 0.9 3.9 0.6 0.8 0.4 0.5 -0.9 -0.9 -2.0 1.4 0.1 0.4 -0.4
Medication: Blood pressure 0.3 0.5 1.6 -0.4 -1.0 -0.0 1.2 0.6 -1.0 -1.3 -0.2 0.3 -0.0 -0.0
Angina (self-reported) 0.3 0.3 1.4 0.4 0.2 -0.0 -1.1 -0.6 1.2 -0.5 -0.4 -0.1 -0.3 -0.4
Migraine (self-reported) 0.5 0.6 3.2 0.0 0.7 0.2 -0.6 -0.4 0.9 -1.8 -1.1 0.1 -0.3 -0.4
Medication: Ibuprofen 1.6 1.9 6.8 -0.6 0.3 -1.2 -2.6 -0.1 2.1 2.1 -0.0 -0.8 -0.7 -1.6
Medication: Allopurinol 0.7 0.9 2.2 -0.9 -1.1 0.2 1.4 0.0 -0.5 -1.5 1.2 -0.9 -0.6 -1.0
Medication: Omeprazole 0.6 0.7 2.0 -0.2 0.1 -1.0 -1.4 -0.6 1.2 -0.1 0.3 -1.0 -1.0 -0.7
Medication: Seretide 50 evohaler 1.5 1.7 3.1 0.8 0.2 1.5 1.7 1.6 -1.8 -1.7 0.4 1.4 0.9 1.3
Mean time to correctly identify matches 0.5 1.0 4.8 -0.4 -0.6 0.9 1.4 0.0 -2.2 0.7 1.2 0.6 0.1 0.7
Heart disease (mother) 1.6 2.0 4.0 1.3 0.8 1.5 1.1 -0.2 -2.0 -0.1 1.9 1.9 1.2 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.7 -1.4 -0.2 -1.5 -1.0 -0.9 0.6 0.7 -0.9 -1.2 -1.6 -0.8
Whole body fat mass 0.8 3.5 14.5 0.2 -0.1 2.7 3.1 0.8 -3.8 -0.6 0.7 1.2 0.1 1.9
Leg fat mass (right) 0.8 3.1 13.6 -0.3 -1.0 2.2 3.3 0.4 -3.7 -0.8 0.4 0.8 -0.5 1.6
Arm predicted mass (right) 1.4 7.4 12.4 2.8 1.3 3.5 3.3 2.4 -2.4 1.2 3.2 2.7 2.9 3.2
Pulse rate, automated reading 1.8 5.8 12.7 -3.0 -1.5 -2.3 -2.4 -3.6 1.2 -2.1 -2.3 -2.5 -2.1 -2.5
Alcohol intake frequency. 0.8 1.9 3.4 0.9 1.3 1.5 1.2 0.7 -1.4 1.9 1.7 1.0 1.5 1.6
Comparative height size at age 10 1.6 9.1 20.2 3.7 3.4 3.8 1.8 2.8 -1.0 0.4 3.1 2.8 4.5 3.2
Number of full sisters 1.9 2.3 4.3 0.6 1.3 2.1 1.9 0.7 -1.6 1.0 1.7 1.1 1.9 1.9
Suffer from ‘nerves’ 0.8 1.3 5.3 -0.5 1.2 -0.5 -2.3 -0.3 1.9 1.5 -0.4 -0.5 0.3 -0.9
Overall health rating 0.4 0.8 1.8 0.4 0.4 1.3 1.0 -0.1 -1.1 -1.1 -0.9 1.1 0.3 1.3
Chest pain or discomfort 0.9 1.4 3.0 -1.5 0.2 -1.3 -0.9 -1.3 0.6 -0.8 -1.2 -1.5 -1.1 -1.7
Had major operations 1.1 1.2 4.7 -1.1 -1.4 -0.6 -0.0 1.0 1.5 -0.7 -2.2 -0.7 -0.4 -0.8
Age at last live birth 3.0 4.4 8.9 -2.4 -3.0 -2.2 -0.2 -1.9 -0.3 -1.6 -1.6 -2.9 -2.8 -1.8
Family relationship satisfaction 2.2 2.7 7.2 -1.4 -0.4 -1.7 -2.7 -1.4 1.9 0.7 -2.1 -1.7 -1.3 -1.4
Leg pain on walking 0.4 0.6 1.8 0.1 -1.0 0.4 1.3 0.7 -0.7 0.1 0.4 -0.3 -0.3 1.4
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 4.3 1.7 1.9 2.0 1.0 -0.2 -0.6 -0.3 2.1 1.5 2.0 1.5
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.5 -0.3 -0.4 -0.2 -1.0 0.0 0.5 -1.2 -0.1 -0.6 -0.7 -0.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.8 0.2 1.0 -0.5 -1.6 -0.5 2.0 1.6 -0.1 -0.6 0.5 -0.5
Medication: Aspirin 0.1 0.1 0.4 -0.2 0.0 0.6 -0.5 0.0 0.4 0.1 -0.1 -0.1 -0.5 0.2
Supplements: Vitamin C 0.6 0.7 2.5 -1.1 -0.3 -0.7 -1.0 -0.9 1.6 -0.5 -0.4 -0.9 -0.4 -0.5
Knee pain experienced in last month 0.3 0.5 2.4 -0.8 0.0 0.6 -0.2 0.3 -0.6 1.5 1.1 -0.2 -0.4 -0.4
Hypertension (Self-reported) 0.3 0.9 3.3 -1.3 -1.8 -0.3 -0.1 -1.5 -0.5 -0.5 -0.7 -0.6 -0.7 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 6.3 -1.4 -1.0 -1.1 -1.0 -1.8 -0.0 -0.7 -1.5 -1.2 -2.5 -0.9
Illnesses of father: Heart disease 0.3 0.4 1.2 0.8 -0.2 1.1 0.4 -0.4 -0.4 -1.0 -0.0 0.8 0.3 0.5
Illnesses of siblings: Diabetes 2.8 3.4 8.1 0.9 0.9 2.3 2.9 0.6 -2.8 1.0 1.4 2.1 1.3 2.3
Smoking status: Previous 0.4 0.6 1.7 1.3 0.7 0.5 0.1 0.8 0.5 0.1 0.7 1.3 0.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.3 7.6 1.9 1.2 2.4 1.8 1.0 -2.1 0.2 2.1 1.1 2.8 1.9
Whole body fat-free mass 1.5 8.3 14.4 3.0 1.8 3.8 3.1 2.9 -2.4 1.2 2.8 2.9 3.4 3.5
Leg fat-free mass (right) 1.5 8.2 14.4 2.5 1.7 3.8 3.3 2.8 -3.1 1.0 2.8 2.7 3.1 3.5
Arm fat percentage (left) 0.5 1.9 10.7 -1.0 -0.8 1.3 1.8 -0.0 -3.3 -0.7 -0.7 0.3 -1.2 0.6
Average weekly red wine intake 1.5 2.2 5.9 -0.9 -0.3 -1.9 -2.3 -0.8 2.1 0.8 -1.1 -1.1 -0.5 -2.4
Handedness (chirality/laterality): Left-handed 2.2 2.7 7.2 -1.4 -2.0 -2.3 -1.0 -1.2 1.2 0.3 -2.7 -1.5 -1.6 -1.4
Mood swings 0.4 0.7 2.7 -1.1 -0.4 0.1 -0.5 -0.0 1.4 -0.2 -1.6 -0.7 0.9 -0.4
Loneliness, isolation 0.3 0.5 2.0 0.0 -0.3 0.3 0.3 -0.1 0.5 -1.3 -1.4 -0.3 0.5 0.7
Long-standing illness, disability or infirmity 0.3 0.5 1.7 0.0 0.7 1.3 0.6 -0.1 -0.2 -0.3 0.9 0.1 0.4 1.2
Ever had bowel cancer screening 0.5 0.6 1.5 0.8 0.3 0.9 0.6 -1.1 -0.4 0.7 1.0 0.3 1.2 0.7
Diabetes diagnosed by doctor 0.7 1.2 6.2 -1.1 1.0 1.2 0.3 0.4 0.0 2.5 0.9 -0.1 0.4 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.6 0.2 0.5 0.3 1.2 0.0 -1.1 -1.1 1.3 -0.1 -0.2 0.8
Friendships satisfaction 1.1 1.3 5.3 -0.6 -0.4 -0.8 -2.3 -0.8 1.9 0.3 -0.7 -1.1 -0.3 -1.4
Qualifications: nursing, teaching 1.6 2.5 8.1 -0.1 -1.5 -1.7 -2.8 -0.6 1.6 0.8 -2.1 -0.5 -1.4 -2.0
Commuting to job workplace: Walk 0.3 0.3 1.1 -0.2 0.7 -0.2 -0.3 -0.9 -0.4 0.1 -1.1 -0.1 -0.1 -0.7
Eye problems/disorders: Cataract 1.6 1.9 3.9 1.7 0.3 1.4 0.9 2.0 -1.4 0.3 0.7 1.8 1.3 1.9
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.7 -1.9 -1.1 -2.2 -1.2 -1.1 1.1 -0.0 -2.1 -1.7 -0.9 -1.9
Medication for cholesterol 0.3 0.4 1.7 -0.5 -0.1 -1.0 0.1 -0.7 -0.5 -1.3 0.0 -0.3 -0.4 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.2 0.4 -1.1 -0.2 0.0 1.0 0.1 -1.0 -0.7 0.4 -0.5 0.3
Back pain experienced in last month 2.2 3.2 5.6 2.4 2.1 2.0 0.1 1.8 -0.5 2.1 1.8 1.8 2.1 1.6
Mineral and other dietary supplements 0.2 0.3 0.9 0.4 0.9 -0.3 -0.7 0.1 0.5 -0.7 -0.6 0.3 -0.0 -0.2
Breast cancer (self-reported) 0.9 1.1 2.1 -1.3 -0.2 -0.8 -0.8 -1.4 1.4 1.5 -1.0 -1.2 -0.3 -0.8
Asthma (self-reported) 2.1 4.1 9.4 -2.2 -0.1 -2.1 -3.1 -0.5 2.9 -1.4 -2.0 -1.7 -1.8 -2.4
Osteoporosis (self-reported) 0.5 0.6 2.1 -0.1 -1.4 0.2 0.8 0.1 -1.4 -1.1 0.3 0.0 -0.6 -0.2
Osteoarthritis (self-reported) 0.4 0.6 1.4 -0.8 0.1 -0.5 -1.2 -1.1 0.6 0.4 -0.2 -0.6 -1.1 -1.0
Medication: Aspirin 0.6 0.7 2.6 0.8 0.8 1.6 0.4 0.8 -0.3 0.3 1.0 0.9 0.3 1.1
Medication: Gliclazide 1.9 2.2 4.5 -0.5 1.3 2.1 1.3 1.1 -0.7 2.1 1.7 0.7 1.5 2.0
Illnesses of father: None of the above (group 1) 0.7 0.9 1.8 -1.3 -1.1 -1.3 0.4 -1.0 -0.2 0.1 -0.6 -1.2 -0.8 -1.3
Smoking status: Current 0.6 1.0 2.4 0.4 1.5 0.4 -0.1 0.8 1.0 1.2 0.4 0.4 1.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.7 0.1 -0.3 0.7 0.9 -1.1 -0.5 -1.3 0.7 0.4 0.2 0.2
Whole body water mass 1.4 8.3 14.1 3.0 1.8 3.8 3.1 2.9 -2.3 1.2 2.8 2.9 3.4 3.5
Leg predicted mass (right) 1.5 8.1 14.2 2.5 1.6 3.8 3.2 2.8 -3.1 1.0 2.8 2.7 3.1 3.5
Arm fat mass (left) 0.5 2.1 9.4 -0.2 -0.1 2.2 2.4 0.7 -3.1 -0.2 0.2 0.9 -0.1 1.5
Number of self-reported non-cancer illnesses 1.3 2.3 10.5 -0.8 -0.2 -1.0 -2.3 -1.0 3.2 0.4 -2.4 -0.8 -0.4 -0.6
Average weekly champagne plus white wine intake 1.2 1.6 3.8 -0.8 -0.8 -1.7 -1.3 -1.1 2.0 0.5 -1.8 -1.4 -1.2 -0.5
Miserableness 1.4 2.5 5.2 -2.1 -1.9 -1.9 0.1 -0.8 0.2 -1.7 -2.3 -1.9 -1.3 -1.3
Guilty feelings 0.8 1.3 2.9 -1.0 -1.5 -1.5 -0.6 -1.0 0.7 -0.6 -1.7 -1.5 -0.7 -0.7
Wears glasses or contact lenses 1.6 1.8 10.1 0.1 0.3 -0.8 -2.3 0.1 3.2 0.6 -1.3 -0.4 -0.2 -1.3
Ever taken oral contraceptive pill 1.6 1.8 3.7 -1.9 -1.7 -1.8 0.3 -1.1 0.4 -0.9 -0.6 -1.8 -1.3 -1.4
Hearing aid user 3.6 4.1 8.6 2.2 1.8 2.9 0.3 1.8 -0.2 2.3 1.1 2.8 2.2 2.4
Mother’s age at death 0.9 1.2 2.3 -1.0 -1.1 -1.4 -0.9 -0.4 1.5 0.2 -1.2 -0.8 -1.4 -1.0
Financial situation satisfaction 0.8 1.0 2.8 -0.6 0.2 -0.5 -1.7 0.2 1.4 1.6 -1.0 -0.8 -0.8 0.3
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.4 -0.5 -0.5 -0.4 0.2 -0.7 -0.7 0.8 1.2 -0.8 0.1 -0.5
Commuting to job workplace: Public transport 1.2 1.4 3.2 -1.1 -1.2 -1.8 -0.0 -1.8 -0.3 0.3 -1.0 -1.0 -1.6 -1.2
Eye problems/disorders: Glaucoma 0.9 1.0 2.8 1.7 -0.1 0.1 -0.3 1.4 1.2 1.5 0.3 0.5 0.9 1.3
Medication: Blood pressure 0.2 0.3 0.9 -0.5 -0.7 -0.2 -0.5 -0.9 0.4 0.5 -0.6 -0.4 -1.0 0.1
Pain type(s) experienced in last month: Hip pain 1.3 1.6 4.7 1.1 2.2 1.6 -0.1 1.7 0.1 0.3 1.3 1.2 1.5 0.8
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.6 -0.2 -1.0 0.9 1.2 -0.9 -1.1 0.2 0.8 -0.4 -0.4 0.4
High cholesterol (Self-reported) 0.5 1.0 2.8 1.4 -0.5 0.4 -0.1 1.7 0.6 1.5 -0.2 1.2 0.6 1.0
Medication: Bendroflumethiazide 0.8 1.1 3.2 1.3 -0.8 1.2 0.9 0.9 -0.0 1.5 0.5 1.1 0.5 1.8
Medication: Paracetamol 1.9 3.0 4.7 -1.7 -0.5 -2.1 -2.0 -2.1 1.6 -0.7 -2.1 -0.9 -2.0 -2.2
Medication: Lisinopril 0.6 0.7 2.0 -0.9 0.5 -0.5 -1.1 -1.0 0.2 0.4 0.9 -0.6 -1.0 -1.4
Medication: Atorvastatin 2.6 3.2 6.8 2.5 1.2 2.0 0.1 2.0 0.4 1.6 1.1 2.4 1.6 2.6
Illnesses of father: High blood pressure 1.3 1.6 5.5 1.1 0.2 1.5 1.0 2.3 -0.6 0.2 0.4 1.1 1.6 1.7
Alcohol drinker status: Never 0.5 0.6 2.5 0.3 -0.8 0.6 1.2 0.3 0.1 1.6 0.7 -0.0 -0.1 1.2
Ever smoked 0.3 0.5 2.0 0.5 0.6 -0.1 -0.3 1.4 1.3 0.8 -0.0 0.5 0.7 0.3
Basal metabolic rate 1.4 7.5 14.1 2.6 1.7 3.8 3.2 2.5 -2.7 0.9 2.6 2.6 3.0 3.4
Leg fat percentage (left) 0.7 2.4 10.2 -1.0 -1.4 1.4 2.4 -0.4 -3.2 -1.1 -0.9 0.5 -1.5 0.7
Arm fat-free mass (left) 1.5 7.6 13.8 2.8 1.7 3.7 3.1 2.5 -2.4 0.7 2.7 3.0 3.1 3.3
Number of operations (self-reported) 0.9 1.3 8.1 0.0 0.9 -0.0 -2.0 -0.2 2.9 0.7 -0.9 0.1 0.6 -0.4
Average weekly beer plus cider intake 0.1 0.1 0.6 0.2 -0.4 0.2 0.3 -0.4 -0.3 0.2 0.8 -0.5 0.4 0.2
Irritability 0.2 0.3 2.5 -0.2 -0.2 0.1 0.7 0.3 0.0 -0.6 -1.6 0.3 0.5 0.1
Risk taking 3.5 5.2 11.0 2.0 0.9 2.6 2.0 2.3 -2.6 1.0 3.3 2.3 2.2 2.7
Ever had prostate specific antigen (PSA) test 1.0 1.1 4.3 -0.3 0.2 -1.3 -1.5 0.2 2.1 -0.2 -0.6 -1.0 -0.1 -1.6
Fractured/broken bones in last 5 years 0.4 0.5 1.5 0.2 -1.2 0.4 0.8 0.2 -1.1 -0.9 0.8 0.2 -0.7 0.6
Age started oral contraceptive pill 1.6 2.0 4.6 0.9 -0.0 2.1 2.0 1.0 -1.3 0.7 1.0 1.5 1.6 1.9
Diastolic blood pressure, automated reading 0.2 0.7 3.2 0.3 -0.6 0.5 1.2 -0.5 -1.8 0.0 0.3 0.7 0.7 0.7
Ever depressed for a whole week 1.5 1.8 3.6 -1.5 -1.5 -1.6 -1.1 -0.7 1.5 -0.6 -1.6 -1.4 -0.3 -1.9
Unable to work because of sickness or disability 0.3 0.3 1.6 0.1 0.2 -0.1 0.8 0.8 -0.6 -1.3 -0.1 0.4 0.1 0.4
Commuting to job workplace: Cycle 0.4 0.5 1.6 0.3 0.8 0.8 0.7 1.3 0.2 0.9 0.3 0.2 0.4 1.0
Myopia 2.8 4.1 9.1 -2.1 -0.4 -3.0 -2.6 -1.0 2.7 1.2 -2.0 -1.8 -0.8 -2.5
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.9 0.9 2.0 0.6 0.4 1.1 -0.2 0.5 0.9 0.6 1.3 0.6
Cholesterol lowering medication 0.2 0.3 0.9 1.0 0.2 0.6 -0.4 0.1 0.6 0.9 -0.5 0.3 -0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.7 -0.1 0.5 -0.9 -1.6 -1.0 1.0 -0.2 0.1 -0.9 -1.2 -0.7
Pain experienced in last month 0.5 0.9 2.1 -0.6 -0.8 -1.3 -0.2 -0.3 0.7 -1.4 -1.2 -0.6 -1.2 -0.8
Supplements: Calcium 0.6 0.6 1.9 -1.4 -0.8 0.1 0.3 -0.6 0.1 -1.0 0.6 -1.3 -0.8 -0.7
Basal cell carcinoma (self-reported) 0.8 1.0 1.8 0.6 0.7 1.3 0.7 1.0 -0.8 1.2 1.1 0.7 1.1 1.3
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.2 0.2 0.1 0.3 0.4 -0.3 -0.1 -0.2 0.0 0.0 -0.2 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.6 -0.3 -0.4 -0.5 -0.0 -0.4 -0.3 -0.6 -0.1 -0.4 -0.8 -0.0
Heart disease (siblings) 0.8 0.9 2.8 0.8 1.7 1.2 0.7 -0.5 -0.5 -0.2 1.1 0.6 0.8 1.4
Alcohol drinker status: Previous 1.2 1.3 4.0 -0.8 1.2 -0.1 -1.5 -2.0 0.7 -1.3 -0.9 -0.4 -0.7 -1.5
Pack years of smoking 0.5 0.7 5.1 -0.4 0.4 0.1 -0.9 0.6 2.3 0.7 0.2 -0.1 0.7 0.0
Impedance of whole body 0.2 0.8 3.2 -0.9 0.1 -0.4 -0.5 -0.8 -0.4 -1.8 0.4 -1.4 -1.1 -0.6
Leg fat mass (left) 0.8 3.2 13.6 -0.1 -0.8 2.3 3.2 0.6 -3.7 -0.7 0.5 1.0 -0.3 1.6
Arm predicted mass (left) 1.7 8.5 14.9 2.9 1.6 3.9 3.3 2.8 -2.6 1.2 3.0 3.1 3.2 3.5