Hub : Genes

CTD-2619J13.14

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.069	0.0350	9.3e-03	0.013	NA	0.007	NA	0.026	3.5e-02	NA	8.6e-02	NA	4.6e-03
2	GTEx	Nerve Tibial	0.117	0.0439	2.9e-04	0.023	NA	0.022	NA	0.021	9.4e-03	NA	1.1e-02	NA	1.1e-02
3	GTEx	Skin Not Sun Exposed Suprapubic	0.139	0.0490	1.4e-03	0.032	NA	0.003	NA	0.023	7.1e-03	NA	2.0e-01	NA	1.9e-02
4	GTEx	Testis	0.286	0.0780	4.5e-08	0.244	NA	0.219	NA	0.181	3.5e-11	NA	4.5e-10	NA	1.8e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	8.7	13.8	18.3	4.3	3.4	-4.0	3.1
Bipolar Disorder or Schizophrenia	6.3	15.3	20.3	3.5	3.5	-4.1	4.5
Depressed Affect (Nagel 2018)	1.1	2.2	3.3	-0.8	-1.8	1.6	-1.6
Depression (Nagel 2018)	0.0	0.1	0.2	0.4	0.2	0.0	-0.1
Intelligence (Savage-Jansen 2018)	2.9	9.1	20.3	4.5	1.6	-3.4	1.3
Neuroticism (Nagel 2018)	0.4	0.9	1.8	0.9	-0.8	0.7	-1.3
Schizophrenia (2018)	2.3	4.8	11.0	1.1	1.8	-2.0	3.3
Schizophrenia vs Biploar Disorder	1.0	1.3	3.6	-1.9	-0.6	1.1	-0.0
Worry (Nagel 2018)	0.4	0.9	2.0	1.2	-0.3	0.1	-1.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3
Alzheimer’s Disease (in father)	0.5	0.5	1.2	0.4	0.6	-0.6	1.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.1	0.2	-0.2	0.6
Crohns Disease (2017)	1.6	3.4	7.5	0.8	1.5	-1.8	2.7
Irritable Bowel Disease (IBD)	1.4	3.3	7.5	0.6	1.5	-1.7	2.7
Ulcerative Colitis (UC)	0.9	1.7	3.9	0.3	1.3	-1.1	2.0
Major Depression (MDD)	3.5	4.3	6.3	2.2	1.8	-2.5	1.7
Reaction Time	1.0	1.8	5.0	-2.2	-0.5	1.4	-0.1
Verbal and Numeric Reasoning (VNR)	1.8	4.3	12.1	3.5	0.8	-2.1	0.0
Breast Cancer	2.2	5.2	9.9	2.1	3.1	-2.3	1.2
Ovarian Cancer	0.1	0.2	0.4	0.6	-0.4	-0.4	-0.2
Prostate Cancer	0.1	0.1	0.4	0.0	0.2	-0.1	-0.6
Age at First Birth	0.8	1.2	3.2	-1.8	-0.8	1.0	0.3
Bipolar Disorder (2011)	3.7	3.6	5.1	2.1	1.6	-2.3	1.5
Body Mass Index (BMI) (2010)	0.3	0.5	1.4	0.6	0.2	0.2	-1.2
Coronary Artery Disease (CAD)	1.2	1.4	2.8	0.0	1.7	-1.0	1.4
Crohns Disease (2012)	1.0	1.6	2.7	1.0	0.8	-1.5	1.6
Mean Putamen Volume	0.7	0.8	1.3	-1.2	-0.5	1.1	-0.4
Fasting Glucose	0.0	0.1	0.1	-0.2	0.3	0.2	-0.2
HbA1C	0.3	0.4	0.6	0.6	0.8	-0.4	0.7
HDL Cholesterol	0.3	0.5	1.4	-0.7	-1.2	0.4	0.1
LDL Cholesterol	0.2	0.4	1.0	0.6	1.0	-0.1	-0.4
Lupus	0.7	1.0	1.6	-0.8	1.2	0.5	1.3
Neuroticism (2016)	1.3	1.9	3.7	-0.4	-1.3	1.4	-1.9
Primary Biliary Cirrhosis	0.6	0.8	2.1	-0.2	-0.6	0.9	-1.5
Rheumatoid Arthritis	0.4	0.6	0.8	-0.7	-0.6	0.9	-0.9
Schizophrenia (2014)	3.0	6.7	11.5	1.7	2.3	-2.6	3.4
Triglycerides	0.3	0.5	1.3	-0.4	-0.3	0.6	-1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	-0.6	0.4	0.4	0.8
Ulcerative Colitis	0.6	0.8	2.2	-0.8	0.5	-0.3	1.5
Blood Eosinophil Count	0.6	4.5	7.4	-1.3	-1.7	2.4	-2.7
Blood Platelet Count	4.3	49.4	91.8	-1.5	-8.0	6.3	-9.6
Blood Red Count	0.3	2.7	5.6	2.1	-0.8	-0.2	-2.4
Blood White Count	1.1	8.2	19.6	-0.3	-2.7	2.4	-4.4
Heel T-Score	2.9	22.9	36.8	-5.9	-3.6	6.1	-2.6
BMI	0.0	0.3	0.7	0.8	0.5	-0.3	-0.1
Height	0.3	6.5	11.6	-1.2	-3.4	2.8	-2.2
Waist Hip Ratio (WHR)	0.2	0.8	2.6	-0.4	-0.1	-0.6	1.6
Systolic Blood Pressure	0.0	0.1	0.3	0.0	0.2	-0.1	0.5
Smoking Status	0.4	0.9	1.4	1.1	-1.0	-0.5	-1.2
Allergy or Eczema	0.4	0.9	2.3	0.4	1.5	-1.0	0.5
Cardiovascular Disease	0.7	2.3	5.4	2.3	0.9	-1.6	0.6
Hypothyroidism (self reported)	1.1	2.6	6.8	-2.6	-0.6	1.8	-0.3
Respiratory disease	0.3	0.7	1.7	-0.6	-0.8	-0.2	1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.5	0.2	-0.7	0.1	-0.3
Lung FEV1/FVC ratio	0.1	0.7	1.3	-0.5	-1.1	0.7	-0.9
Lung FVC	0.1	0.6	1.3	-0.7	-1.1	0.7	-0.4
Neuroticism	1.1	2.7	6.0	-0.1	-1.6	1.4	-2.5
Chronotype (morning person)	1.9	4.4	10.9	-1.2	2.0	-1.1	3.3
Hair Pigment	0.2	6.3	9.6	-2.1	-2.8	3.1	-1.9
Tanning	0.1	0.7	1.7	-1.3	-0.8	0.5	-0.2
Hand grip strength (left)	1.0	2.7	4.1	-1.4	-1.7	2.0	-1.4
Number of treatments/medications taken	0.8	1.5	3.9	2.0	0.7	-1.2	0.1
Average weekly spirits intake	0.1	0.2	0.2	-0.3	-0.5	0.4	0.4
Sensitivity / hurt feelings	1.5	2.6	7.3	2.7	1.1	-1.4	-0.0
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	-0.1	-0.5	0.2	-0.0
Hearing difficulty/problems: Yes	5.5	8.5	12.3	-2.7	-3.5	3.0	-2.2
Relative age of first facial hair	1.4	2.8	7.9	2.8	1.0	-0.8	-1.3
Other serious medical condition/disability diagnosed by doctor	4.9	6.3	10.8	-2.9	-2.0	3.3	-1.4
Ever used hormone-replacement therapy (HRT)	1.5	1.8	2.9	1.4	1.3	-1.7	0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.1	-0.7	0.4	-0.3
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.4	-0.1	0.3	-0.2
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	4.4	1.2	1.7	-1.6	2.1
Angina	0.2	0.3	0.4	-0.2	0.5	-0.6	0.6
Medication for hormone replacement therapy	4.4	4.9	6.2	2.3	1.9	-2.5	2.1
Vitamin and mineral supplements	5.3	7.2	11.0	-3.3	-1.9	3.2	-2.0
Supplements: Zinc	6.1	6.6	7.8	2.2	2.6	-2.8	2.7
Medication: Co-codamol	0.3	0.4	0.7	0.8	0.6	-0.6	0.4
Medication: Metformin	0.2	0.3	0.7	0.8	-0.2	-0.5	0.3
Diabetes (father)	2.4	3.0	4.6	1.7	1.9	-2.1	1.0
Diabetes (mother)	2.0	2.5	3.6	1.9	1.4	-1.6	1.3
Severe depression (siblings)	7.0	7.8	10.0	2.3	2.7	-3.2	2.9
Pack years adult smoking proportion	0.4	0.6	1.2	-0.6	0.3	1.1	-0.9
Impedance of leg (right)	0.1	0.4	1.2	-0.3	-1.1	0.2	-0.4
Leg fat-free mass (left)	0.2	1.1	2.7	1.6	0.4	-0.6	1.0
Trunk fat percentage	0.1	0.5	1.5	1.2	-0.5	-0.2	-0.3
Hand grip strength (right)	1.5	4.1	6.6	-1.2	-2.6	2.1	-2.0
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.2	-0.0	-0.1	-0.0
Current tobacco smoking	1.4	2.2	3.9	-1.1	-1.3	1.5	-2.0
Average weekly fortified wine intake	0.1	0.1	0.5	0.7	-0.2	-0.2	-0.0
Maternal smoking around birth	1.2	1.8	3.3	1.8	1.4	-1.2	0.7
Fed-up feelings	0.1	0.2	0.5	-0.3	-0.7	0.3	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.9	0.7	1.0	-0.9	0.7
Relative age voice broke	1.3	2.1	6.4	2.5	-0.0	-0.5	-1.2
Taking other prescription medications	0.3	0.5	0.9	0.7	0.6	-0.9	0.6
Age when periods started (menarche)	1.3	3.1	7.6	2.8	-0.6	-0.9	-1.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.4	-0.3	0.0	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	8.9	-1.5	-1.8	3.0	-1.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.2	-0.3	-0.1	-0.8
Qualifications: CSEs or equivalent	2.2	2.9	3.7	1.6	1.9	-1.9	1.4
Serious illness, injury or assault to yourself	2.1	2.5	4.2	-2.0	-2.1	1.3	0.2
High blood pressure	1.0	2.8	4.5	2.1	1.4	-1.7	1.3
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.3	1.1	1.8	-1.6	0.9
Multivitamins +/- minerals	3.5	4.5	6.2	2.4	1.8	-2.5	1.6
Stomach or abdominal pain in last month	3.9	4.8	9.2	3.0	1.2	-2.6	1.2
Supplements: Glucosamine	1.3	1.7	2.6	1.5	0.9	-1.6	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.3	-0.5	-0.2	0.7
Medication: Atenolol	1.8	2.2	3.5	1.9	1.2	-1.8	0.8
Medication: Levothyroxine sodium	3.1	5.2	8.0	-2.8	-1.8	2.6	-1.8
Sitting height	0.4	2.5	5.2	-1.0	-2.3	1.6	-1.1
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	-0.3	0.5	0.1	0.6
High blood pressure (mother)	2.6	3.6	4.8	1.9	2.1	-2.2	1.1
Body mass index (BMI)	0.1	0.3	0.9	0.9	0.5	-0.2	0.2
Impedance of leg (left)	0.1	0.7	1.6	-0.6	-1.2	0.5	-0.8
Leg predicted mass (left)	0.2	1.0	2.5	1.6	0.4	-0.6	0.9
Trunk fat mass	0.1	0.5	1.5	1.2	-0.6	-0.1	-0.1
Waist circumference	0.2	0.9	2.4	1.6	0.3	-0.7	0.7
Number of incorrect matches in round	1.2	2.0	4.3	-2.1	-0.9	1.7	-0.2
Past tobacco smoking	1.9	3.5	8.4	-2.9	-0.2	2.3	0.1
Alcohol usually taken with meals	0.2	0.3	0.7	-0.5	0.8	-0.1	0.6
Nervous feelings	0.4	0.8	1.7	0.1	-1.3	0.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.7	-0.5	-0.3	-0.7
Hearing difficulty/problems with background noise	0.6	0.9	1.4	-0.7	-1.2	1.2	-0.6
Hair/balding pattern: Pattern 2	0.8	1.0	1.7	1.3	0.7	-1.3	0.4
Had menopause	0.5	0.7	0.9	-0.6	-0.9	0.8	-0.9
Had other major operations	1.1	1.3	4.1	0.6	-0.9	0.1	-2.0
Forced vital capacity (FVC)	0.2	0.9	2.1	0.5	-1.4	0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	6.3	-1.6	-1.6	2.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	-0.1	0.6	-0.5	1.6
Qualifications: None of the above	0.5	1.0	2.5	-1.6	-0.3	1.1	-0.3
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.6	0.1	0.5	-0.4
Mouth/teeth dental problems	0.8	1.2	1.9	-1.1	-0.4	1.2	-1.4
Heart attack	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.3
Allergy	0.9	2.1	3.9	-0.8	-2.0	1.5	-1.2
Pain all over the body in last month	2.1	2.2	3.5	1.9	1.5	-1.6	0.6
Diabetes (self-reported)	0.2	0.2	0.4	0.7	0.5	-0.4	0.3
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	2.8	1.3	1.6	-1.3	1.7
Medication: Ramipril	0.6	0.8	1.9	1.0	0.5	-1.4	0.2
Medication: Simvastatin	0.4	0.5	0.9	-1.0	-0.6	0.9	-0.3
Fluid intelligence score	2.1	4.3	11.4	3.4	1.0	-2.2	0.1
Illnesses of siblings	0.2	0.3	0.7	-0.7	0.1	0.8	-0.2
Neuroticism score	0.7	1.4	3.7	-0.2	-0.9	1.2	-1.9
Weight	0.1	0.4	1.1	1.1	-0.6	0.2	-0.1
Impedance of arm (right)	0.1	0.7	1.4	1.0	0.3	-1.2	0.4
Arm fat percentage (right)	0.1	0.5	1.4	1.2	0.4	-0.5	0.5
Trunk fat-free mass	0.0	0.2	0.5	0.2	-0.7	0.7	0.0
Hip circumference	0.2	0.7	2.5	1.6	-0.1	-0.5	0.3
Time employed in main current job	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.3	-0.2	0.2
Father’s age at death	0.4	0.5	0.7	-0.4	-0.9	0.6	-0.9
Worrier / anxious feelings	0.0	0.0	0.1	0.1	0.2	0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.4	-0.6	0.1	-0.8
Falls in the last year	0.2	0.3	1.2	-0.2	1.1	0.2	-0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.1	-0.4	-0.4	0.3
Number of live births	0.1	0.1	0.3	0.6	0.1	0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.0	0.0	-1.7	0.2	-1.3
Pulse rate	1.6	2.8	7.6	-0.8	-2.8	1.0	-1.3
Happiness	0.2	0.2	0.8	-0.9	-0.1	0.4	0.0
Noisy workplace	0.2	0.2	0.5	-0.4	0.7	0.3	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.4	1.2	-1.0	-0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.5	-0.6	0.3	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.4	-0.1	-0.5	0.6
Asthma	0.7	1.4	3.2	0.4	1.0	-1.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.8	3.0	1.4	0.7	-1.7	1.4
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.4	0.3	0.7	-0.7
Depression (self-reported)	1.6	1.9	4.6	2.1	1.0	-1.4	-0.2
Medication: Lansoprazole	5.3	6.1	9.7	-1.7	-2.4	2.5	-3.1
Prospective memory result	1.5	1.8	3.9	0.5	1.5	-1.0	2.0
Lung cancer (father)	0.2	0.2	0.4	0.1	0.3	0.4	-0.7
Illnesses of mother	3.4	4.2	5.4	-1.9	-2.3	2.1	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.7	0.2	-1.7	0.2	-0.7
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.3	-0.4	0.0	-0.6
Impedance of arm (left)	0.1	0.4	0.9	0.4	-0.9	-0.4	-0.4
Arm fat mass (right)	0.1	0.5	1.4	1.2	0.4	-0.4	0.5
Trunk predicted mass	0.0	0.2	0.4	0.3	-0.6	0.6	0.1
Standing height	0.1	1.3	4.1	0.5	-2.0	0.6	-0.5
Length of working week for main job	1.4	1.5	4.1	0.3	0.6	-1.2	2.0
Exposure to tobacco smoke at home	0.3	0.4	0.8	0.9	0.1	-0.7	0.5
Breastfed as a baby	0.1	0.2	0.3	-0.2	-0.4	0.4	-0.5
Tense / ‘highly strung’	0.5	0.8	1.8	1.3	0.5	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	6.9	2.2	1.7	-2.6	2.3
Hair/balding pattern: Pattern 4	3.0	7.4	9.8	-2.4	-2.0	3.1	-3.1
Birth weight of first child	1.0	1.9	3.5	-0.8	-0.7	1.7	-1.9
Peak expiratory flow (PEF)	0.4	1.0	1.5	1.1	-1.2	-0.7	-0.9
Pulse wave reflection index	2.0	2.5	4.9	1.5	2.2	-1.3	1.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	0.8	1.0	-1.2	0.6
Loud music exposure frequency	0.2	0.3	0.8	0.9	-0.1	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	8.6	2.9	0.9	-2.5	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.2	0.4	-0.5	0.7
Blood clot in the leg (DVT)	0.6	0.8	1.3	-1.1	-0.5	1.1	-0.7
Medication: Paracetamol	0.4	0.7	1.0	0.7	1.0	-0.9	0.7
Headache pain in last month	3.3	5.7	8.3	2.9	1.8	-2.8	1.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	-0.6	-0.9	0.4	-0.1
Glaucoma (self-reported)	0.4	0.4	0.9	-0.9	0.1	0.3	1.0
Gout (self-reported)	3.4	4.6	5.2	2.3	2.1	-2.2	2.0
Hypothyroidism/myxoedema (self-reported)	1.7	3.2	6.3	-2.5	-1.2	2.1	-1.0
Medication: Amlodipine	0.0	0.1	0.1	0.2	0.2	0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.1	0.7	-0.4	1.2
Birth weight	3.1	6.7	10.4	-1.9	-3.2	2.7	-2.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	-0.5	1.0	-0.5	0.9
High blood pressure (siblings)	0.1	0.2	0.4	0.4	-0.6	0.1	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	2.9	0.3	-1.7	0.3	-0.4
Body fat percentage	0.1	0.4	1.2	1.1	-0.6	-0.1	-0.2
Leg fat percentage (right)	0.1	0.3	0.8	0.4	-0.9	0.5	-0.3
Arm fat-free mass (right)	0.0	0.2	0.3	0.5	-0.5	0.3	0.2
Exposure to tobacco smoke outside home	0.4	0.5	1.2	0.5	0.8	-0.4	1.1
Comparative body size at age 10	0.2	0.7	1.9	1.4	-0.6	-0.3	-0.5
Number of full brothers	0.9	1.1	2.7	-1.6	-0.8	1.0	-0.2
Worry too long after embarrassment	0.6	0.9	2.7	0.5	-0.6	0.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	4.9	1.4	1.8	-2.2	2.0
Wheeze or whistling in the chest in last year	1.2	2.1	2.7	1.2	1.3	-1.6	1.6
Number of children fathered	0.5	0.5	1.1	0.1	-1.0	0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-1.0	-0.0	0.6	-0.7
Age at first live birth	0.2	0.4	0.9	-1.0	-0.5	0.6	-0.2
Pulse wave peak to peak time	0.1	0.2	0.4	-0.5	0.3	0.1	0.6
Health satisfaction	0.3	0.4	1.1	-1.0	-0.2	0.5	0.6
Shortness of breath walking on level ground	0.3	0.3	0.5	-0.5	-0.2	0.7	-0.7
Qualifications: College or University degree	0.3	0.8	1.1	-0.7	-1.0	1.0	-0.9
Eye problems/disorders: None of the above	1.1	1.2	3.7	0.1	-0.6	0.9	-1.9
Mouth/teeth dental problems: Loose teeth	3.8	4.6	5.9	1.8	2.4	-2.3	2.0
Emphysema/chronic bronchitis	0.9	1.1	1.7	-1.3	-1.3	0.7	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.6	-0.2	0.0	-0.6
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.2
Medication: Blood pressure	0.7	1.2	2.0	1.0	1.4	-1.1	0.8
Angina (self-reported)	0.2	0.3	0.5	-0.4	0.5	-0.5	0.7
Migraine (self-reported)	0.1	0.1	0.2	0.4	0.2	-0.3	-0.3
Medication: Ibuprofen	0.8	1.0	1.5	1.1	-0.1	-1.2	1.1
Medication: Allopurinol	3.3	4.4	5.3	2.3	2.2	-2.3	1.6
Medication: Omeprazole	0.5	0.5	1.1	-0.6	-0.6	0.5	-1.1
Medication: Seretide 50 evohaler	0.5	0.5	0.7	0.7	0.6	-0.7	0.8
Mean time to correctly identify matches	2.3	4.3	8.7	-2.9	-1.3	2.6	-0.6
Heart disease (mother)	0.1	0.2	0.3	-0.1	0.5	0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	0.6	1.1	-0.9	-0.2
Whole body fat mass	0.1	0.3	0.9	0.9	-0.6	0.1	-0.2
Leg fat mass (right)	0.1	0.3	0.9	1.0	-0.4	0.0	0.1
Arm predicted mass (right)	0.0	0.2	0.4	0.6	-0.6	0.3	0.3
Pulse rate, automated reading	0.5	1.5	5.6	0.0	-2.4	0.2	-0.5
Alcohol intake frequency.	1.9	4.3	5.4	2.3	2.3	-2.1	1.5
Comparative height size at age 10	0.3	1.8	4.1	-0.9	-2.0	1.2	0.8
Number of full sisters	0.7	0.9	2.0	-1.2	0.0	0.3	1.4
Suffer from ‘nerves’	0.2	0.3	0.4	0.6	-0.5	0.2	-0.7
Overall health rating	0.1	0.2	0.5	0.7	0.4	-0.3	0.2
Chest pain or discomfort	1.4	2.0	2.7	1.5	1.2	-1.6	1.3
Had major operations	0.2	0.3	1.1	0.0	-0.1	0.1	1.1
Age at last live birth	0.1	0.2	0.4	-0.5	0.7	-0.3	0.2
Family relationship satisfaction	0.5	0.6	1.3	0.4	1.1	-0.6	0.8
Leg pain on walking	1.7	2.1	3.2	-1.2	-1.2	1.6	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.1	0.6	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.4	-0.4	0.0	-0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	0.8	0.6	-0.5	-0.6
Medication: Aspirin	0.6	0.8	1.8	0.3	1.4	-0.6	1.0
Supplements: Vitamin C	5.7	6.8	9.4	2.2	2.7	-3.1	2.4
Knee pain experienced in last month	0.1	0.2	0.3	0.3	0.2	-0.6	0.4
Hypertension (Self-reported)	1.3	3.6	5.0	2.2	1.5	-2.1	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.1	-1.2	-0.6	1.4	-1.1
Illnesses of father: Heart disease	0.8	1.1	1.4	1.0	1.2	-1.1	0.7
Illnesses of siblings: Diabetes	0.5	0.6	1.5	1.2	-0.1	-0.7	-0.6
Smoking status: Previous	1.9	2.8	5.9	2.4	0.2	-2.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.2	-0.4	-0.3	-0.0
Whole body fat-free mass	0.0	0.2	0.7	0.9	-0.2	0.1	0.4
Leg fat-free mass (right)	0.1	0.6	1.6	1.3	0.4	-0.5	0.8
Arm fat percentage (left)	0.1	0.3	1.2	1.1	-0.1	-0.3	0.1
Average weekly red wine intake	0.1	0.2	0.3	-0.6	-0.2	0.2	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	0.0	1.2	-0.2	1.0
Mood swings	1.1	1.9	3.5	-0.1	-1.6	1.3	-1.9
Loneliness, isolation	0.7	1.0	1.3	1.1	1.0	-0.7	1.0
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.6	-0.3	0.1	-0.8
Ever had bowel cancer screening	0.2	0.2	0.4	0.0	-0.0	-0.6	0.7
Diabetes diagnosed by doctor	1.0	1.6	2.0	1.4	1.3	-1.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	1.9	0.9	1.4	-1.2	1.1
Friendships satisfaction	0.3	0.4	1.1	-0.5	0.4	-0.2	1.0
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.5
Commuting to job workplace: Walk	1.0	1.0	3.5	-1.9	-0.0	0.8	-0.1
Eye problems/disorders: Cataract	2.4	2.7	4.4	1.0	1.5	-2.1	1.8
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.3	2.3	-0.1	-1.6	0.6
Medication for cholesterol	1.3	2.0	2.3	-1.1	-1.5	1.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	6.1	2.5	1.7	-2.2	0.9
Back pain experienced in last month	0.7	1.1	1.5	-0.8	-1.1	1.2	-1.0
Mineral and other dietary supplements	0.3	0.3	0.7	-0.8	0.2	0.8	-0.2
Breast cancer (self-reported)	0.9	1.1	1.8	-0.4	1.3	-0.9	1.3
Asthma (self-reported)	0.9	1.8	3.9	0.6	1.1	-1.3	2.0
Osteoporosis (self-reported)	3.0	3.7	9.5	3.1	1.1	-2.0	0.2
Osteoarthritis (self-reported)	2.1	2.7	5.8	-2.4	-1.6	1.6	0.3
Medication: Aspirin	0.1	0.1	0.5	-0.2	0.7	0.1	0.1
Medication: Gliclazide	0.5	0.6	0.9	-0.4	-0.9	0.6	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.2	2.7	-0.3	-1.6	1.1	-1.0
Smoking status: Current	0.9	1.5	2.8	-0.8	-1.0	1.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	0.0	-0.6	0.2	-0.8
Whole body water mass	0.0	0.2	0.5	0.7	-0.1	0.2	0.5
Leg predicted mass (right)	0.2	0.8	2.0	1.4	0.5	-0.6	0.8
Arm fat mass (left)	0.1	0.2	0.8	0.9	-0.0	-0.1	0.3
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	-0.2	0.0	0.4	0.3
Average weekly champagne plus white wine intake	0.2	0.3	1.0	-0.4	-0.1	-0.3	1.0
Miserableness	0.1	0.2	0.8	-0.3	-0.9	0.1	-0.2
Guilty feelings	0.0	0.1	0.1	-0.2	0.1	-0.1	0.4
Wears glasses or contact lenses	1.0	1.1	2.2	1.5	0.5	-1.2	0.8
Ever taken oral contraceptive pill	4.0	4.4	5.8	2.0	2.3	-2.4	1.6
Hearing aid user	0.6	0.7	1.4	-0.6	-0.8	0.7	-1.2
Mother’s age at death	0.7	0.9	2.3	-1.0	0.3	0.4	1.5
Financial situation satisfaction	0.5	0.6	0.9	0.2	0.9	-0.7	1.0
Tinnitus: Yes, now most or all of the time	2.6	3.0	5.0	-2.2	-1.9	1.8	-0.5
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.4	-0.7	0.5	-0.5
Eye problems/disorders: Glaucoma	1.1	1.3	4.3	-0.8	0.4	-0.5	2.1
Medication: Blood pressure	0.2	0.5	0.8	0.5	0.5	-0.7	0.9
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	0.0	-0.3	0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.6	0.3	-0.8	-0.2	-0.3
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.5	-0.3	0.6	-0.2
Medication: Bendroflumethiazide	0.4	0.6	1.0	-1.0	-1.0	0.7	-0.0
Medication: Paracetamol	0.6	0.9	1.1	0.9	0.9	-1.1	0.9
Medication: Lisinopril	0.2	0.3	0.6	0.5	-0.2	0.4	-0.8
Medication: Atorvastatin	0.0	0.1	0.2	-0.2	0.4	0.0	-0.1
Illnesses of father: High blood pressure	0.7	0.9	1.6	-1.2	-0.8	0.9	-0.6
Alcohol drinker status: Never	6.2	7.5	8.9	2.8	3.0	-2.9	2.2
Ever smoked	2.6	4.5	11.5	3.4	0.5	-2.5	-0.5
Basal metabolic rate	0.0	0.2	0.7	0.8	-0.2	0.1	0.4
Leg fat percentage (left)	0.1	0.4	0.7	0.3	-0.8	0.6	-0.5
Arm fat-free mass (left)	0.0	0.2	0.3	0.3	-0.3	0.4	0.5
Number of operations (self-reported)	0.2	0.3	0.7	0.8	0.4	-0.5	0.4
Average weekly beer plus cider intake	0.1	0.2	0.6	0.3	0.8	-0.3	0.2
Irritability	0.6	1.0	3.0	1.7	0.5	-0.8	-0.3
Risk taking	1.1	1.7	2.9	1.2	1.1	-1.7	1.0
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.1	-1.8	-1.5	1.6	-1.0
Fractured/broken bones in last 5 years	0.7	0.8	1.4	0.4	1.2	-0.9	1.0
Age started oral contraceptive pill	1.1	1.3	2.9	-0.5	-1.1	1.0	-1.7
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.3	-0.4	0.2	-0.0
Ever depressed for a whole week	1.3	1.6	2.7	-1.1	-1.6	1.0	-1.2
Unable to work because of sickness or disability	0.4	0.5	1.0	1.0	0.7	-0.8	0.2
Commuting to job workplace: Cycle	0.4	0.5	1.2	0.2	0.4	-0.6	1.1
Myopia	3.4	4.9	8.4	2.9	1.6	-2.6	1.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.0	-1.7	-1.1	1.5	-0.8
Cholesterol lowering medication	0.7	1.1	2.1	-1.5	-1.0	1.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	-0.1	-0.6	0.0	-0.9
Pain experienced in last month	0.3	0.5	0.8	-0.5	-0.8	0.9	-0.5
Supplements: Calcium	6.3	6.9	9.9	3.1	2.2	-3.1	1.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.2	0.6	-0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.2	0.1	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	-0.2	0.8	-0.1
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.1	0.0	0.4
Alcohol drinker status: Previous	0.1	0.1	0.3	0.5	0.0	-0.2	-0.1
Pack years of smoking	0.2	0.3	0.4	-0.2	0.6	0.6	-0.5
Impedance of whole body	0.1	0.4	1.1	0.3	-1.1	-0.3	-0.4
Leg fat mass (left)	0.1	0.2	0.7	0.8	-0.4	0.1	-0.0
Arm predicted mass (left)	0.0	0.2	0.2	0.4	-0.4	0.5	0.4