Hub : Genes

CTD-3184A7.4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.090 0.0330 0.0013 -0.001 NA 0.004 NA -0.002 0.43 NA 0.14 NA 0.470
2 GTEx Nerve Tibial 0.106 0.0452 0.0096 0.003 NA 0.015 NA 0.016 0.18 NA 0.03 NA 0.026

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.7 2.6 2.8 1.6 -1.7
Bipolar Disorder or Schizophrenia 2.4 5.9 8.8 1.8 -3.0
Depressed Affect (Nagel 2018) 0.6 1.3 2.5 1.6 -0.2
Depression (Nagel 2018) 1.3 1.9 3.7 0.2 1.9
Intelligence (Savage-Jansen 2018) 0.6 1.7 3.5 0.0 -1.9
Neuroticism (Nagel 2018) 0.4 0.8 0.9 1.0 -0.9
Schizophrenia (2018) 1.5 3.0 5.5 0.8 -2.3
Schizophrenia vs Biploar Disorder 0.2 0.3 0.5 0.2 0.7
Worry (Nagel 2018) 0.5 1.0 1.8 0.4 -1.3
Alzheimer’s Disease (in mother) 0.9 1.0 1.9 1.4 -0.4
Alzheimer’s Disease (in father) 0.5 0.5 1.1 -0.0 1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 1.1 1.0 -0.4
Crohns Disease (2017) 8.4 18.4 36.5 -6.0 0.6
Irritable Bowel Disease (IBD) 11.3 26.8 52.4 -7.2 1.1
Ulcerative Colitis (UC) 5.1 9.5 18.7 -4.3 0.6
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.6 1.1 2.1 -1.4 -0.3
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.6 -0.7 -0.8
Breast Cancer 0.2 0.5 1.0 0.2 -1.0
Ovarian Cancer 0.9 1.2 2.4 -1.6 0.1
Prostate Cancer 5.6 7.8 13.9 -3.7 1.3
Age at First Birth 3.1 4.6 4.8 2.2 -2.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.5 0.8 -0.9 0.4
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 6.0 9.6 19.1 -4.4 0.4
Mean Putamen Volume 1.5 1.7 3.0 -1.7 0.6
Fasting Glucose 1.1 1.3 2.5 0.1 -1.6
HbA1C 0.9 1.0 1.6 0.6 -1.3
HDL Cholesterol 0.5 0.8 0.8 0.8 -0.9
LDL Cholesterol 0.5 0.7 1.4 1.2 -0.2
Lupus 0.5 0.8 1.4 0.5 -1.2
Neuroticism (2016) 1.5 2.1 2.9 1.1 1.7
Primary Biliary Cirrhosis 1.8 2.6 5.1 -0.3 2.3
Rheumatoid Arthritis 1.1 1.4 2.7 -1.7 0.4
Schizophrenia (2014) 1.2 2.7 4.0 1.2 -2.0
Triglycerides 0.6 0.9 1.5 -0.6 1.2
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 5.8 8.4 11.4 -3.4 2.3
Blood Eosinophil Count 0.6 4.3 8.3 -2.9 0.6
Blood Platelet Count 1.6 18.7 27.1 -5.2 3.2
Blood Red Count 1.5 14.7 17.6 -4.2 3.4
Blood White Count 3.1 23.2 26.7 -5.2 4.4
Heel T-Score 0.7 5.9 9.9 3.1 1.4
BMI 2.8 16.0 23.1 -3.0 4.8
Height 0.3 5.8 6.7 -2.6 -2.2
Waist Hip Ratio (WHR) 0.7 3.3 6.5 -2.5 -0.2
Systolic Blood Pressure 1.7 8.3 16.0 -0.8 4.0
Smoking Status 4.7 11.2 17.3 -4.2 2.3
Allergy or Eczema 6.1 16.1 32.0 -5.7 0.5
Cardiovascular Disease 2.5 8.4 13.8 -1.7 3.7
Hypothyroidism (self reported) 0.5 1.2 1.7 0.8 1.3
Respiratory disease 4.5 9.9 12.6 -3.5 2.7
Type 2 Diabetes (T2D) (2018) 3.5 6.6 7.8 -2.3 2.8
Lung FEV1/FVC ratio 0.1 0.7 0.8 -0.7 -0.9
Lung FVC 11.1 56.6 85.2 9.2 -5.3
Neuroticism 0.2 0.4 0.6 0.5 0.7
Chronotype (morning person) 0.1 0.3 0.3 -0.5 0.6
Hair Pigment 0.3 7.6 15.1 -3.9 0.4
Tanning 0.0 0.0 0.1 0.1 -0.3
Hand grip strength (left) 2.6 6.9 11.7 1.5 3.4
Number of treatments/medications taken 2.0 3.6 6.9 -0.6 2.6
Average weekly spirits intake 0.3 0.3 0.6 -0.8 0.3
Sensitivity / hurt feelings 1.8 3.1 3.5 1.6 1.9
Frequency of depressed mood in last 2 weeks 1.3 1.9 3.7 -0.0 1.9
Hearing difficulty/problems: Yes 0.2 0.3 0.4 -0.5 -0.6
Relative age of first facial hair 0.9 1.9 2.6 -1.6 -1.1
Other serious medical condition/disability diagnosed by doctor 2.8 3.6 3.9 -1.8 2.0
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 0.8 -0.3
Ever had hysterectomy (womb removed) 0.5 0.5 1.0 1.0 0.4
Systolic blood pressure, automated reading 2.7 7.8 12.4 -1.8 3.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.5 -0.3 0.7
Angina 2.2 2.9 4.3 1.2 2.1
Medication for hormone replacement therapy 3.3 3.7 6.1 2.5 1.1
Vitamin and mineral supplements 0.3 0.4 0.7 0.8 0.4
Supplements: Zinc 0.2 0.3 0.4 -0.3 -0.6
Medication: Co-codamol 3.1 3.6 7.1 -0.1 2.7
Medication: Metformin 2.4 3.4 5.7 -1.1 2.4
Diabetes (father) 0.4 0.5 0.8 -0.9 0.4
Diabetes (mother) 0.2 0.2 0.2 -0.5 -0.4
Severe depression (siblings) 2.4 2.7 4.0 -1.2 2.0
Pack years adult smoking proportion 8.6 13.1 18.9 -2.7 4.3
Impedance of leg (right) 0.9 4.5 7.9 -2.8 -1.0
Leg fat-free mass (left) 0.7 3.8 7.6 -0.2 2.8
Trunk fat percentage 3.2 12.8 17.2 -4.1 2.9
Hand grip strength (right) 2.4 6.5 10.5 1.6 3.2
Townsend deprivation index at recruitment 0.2 0.3 0.5 -0.3 -0.7
Current tobacco smoking 7.8 12.8 13.4 -3.7 3.5
Average weekly fortified wine intake 0.7 0.8 1.0 1.0 -0.8
Maternal smoking around birth 2.3 3.4 4.4 -1.5 2.1
Fed-up feelings 0.5 0.8 1.6 0.4 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.4 4.6 9.0 -0.4 3.0
Relative age voice broke 0.4 0.7 1.0 -1.0 -0.6
Taking other prescription medications 1.4 2.1 2.4 -1.4 1.5
Age when periods started (menarche) 0.0 0.0 0.1 -0.3 0.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.1 -0.4 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 3.1 0.6 1.8
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.0 1.4 0.0
Qualifications: CSEs or equivalent 1.3 1.7 2.7 -0.9 1.6
Serious illness, injury or assault to yourself 3.5 4.3 5.5 -1.7 2.4
High blood pressure 2.5 6.9 13.8 -0.1 3.7
Hayfever, allergic rhinitis or eczema 6.0 13.0 25.3 -5.0 0.9
Multivitamins +/- minerals 0.2 0.3 0.5 0.0 -0.7
Stomach or abdominal pain in last month 0.2 0.3 0.5 0.7 0.3
Supplements: Glucosamine 0.0 0.0 0.0 -0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.0 1.4 -0.7
Medication: Atenolol 1.4 1.7 2.3 -1.1 1.5
Medication: Levothyroxine sodium 0.4 0.7 1.3 0.2 1.1
Sitting height 1.3 9.2 16.2 4.0 -1.4
Chronic bronchitis/emphysema (father) 1.6 1.9 2.3 -1.5 1.2
High blood pressure (mother) 0.1 0.2 0.4 0.1 -0.6
Body mass index (BMI) 3.2 13.7 24.1 -1.8 4.9
Impedance of leg (left) 1.0 4.9 8.1 -2.8 -1.3
Leg predicted mass (left) 0.8 4.0 7.9 -0.4 2.8
Trunk fat mass 2.8 11.8 12.1 -3.5 3.4
Waist circumference 3.9 14.4 17.1 -3.4 4.1
Number of incorrect matches in round 2.5 4.2 8.2 2.9 -0.4
Past tobacco smoking 1.7 3.1 3.2 1.8 -1.7
Alcohol usually taken with meals 2.4 3.9 7.8 0.3 -2.8
Nervous feelings 0.3 0.6 0.7 0.8 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 0.8 -0.8 0.9
Hearing difficulty/problems with background noise 0.6 1.0 1.7 -1.3 0.5
Hair/balding pattern: Pattern 2 3.0 3.8 6.9 -0.9 2.6
Had menopause 0.3 0.4 0.7 -0.2 -0.9
Had other major operations 0.2 0.2 0.2 -0.5 -0.4
Forced vital capacity (FVC) 7.0 26.9 37.8 6.2 -4.0
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 3.7 0.7 1.9
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.5 0.5 1.6
Qualifications: None of the above 0.7 1.5 2.5 -0.7 1.6
Financial difficulties in last 2 years 0.8 1.1 2.0 -1.4 0.4
Mouth/teeth dental problems 1.6 2.5 4.8 2.2 0.4
Heart attack 1.4 1.8 2.3 1.1 1.5
Allergy 7.8 18.0 29.2 5.4 -2.6
Pain all over the body in last month 1.4 1.5 1.7 -1.3 1.1
Diabetes (self-reported) 2.2 3.4 3.8 -1.9 1.8
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 3.1 -1.8 0.8
Medication: Ramipril 0.5 0.6 1.2 -0.1 1.1
Medication: Simvastatin 0.5 0.7 0.9 -0.9 0.7
Fluid intelligence score 0.3 0.6 1.1 0.4 -1.0
Illnesses of siblings 0.4 0.5 0.5 -0.7 -0.7
Neuroticism score 0.3 0.6 0.8 0.6 0.9
Weight 1.9 9.3 15.2 -1.9 3.9
Impedance of arm (right) 2.0 9.2 14.7 -1.9 -3.8
Arm fat percentage (right) 2.7 10.6 10.9 -3.2 3.3
Trunk fat-free mass 0.6 3.2 5.8 0.8 2.4
Hip circumference 3.4 14.7 18.5 -3.3 4.3
Time employed in main current job 0.7 0.8 0.8 0.8 -0.9
Alcohol intake versus 10 years previously 0.2 0.2 0.5 -0.1 0.7
Father’s age at death 2.2 2.9 5.7 -0.4 -2.4
Worrier / anxious feelings 0.3 0.6 0.7 -0.8 -0.8
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.0 6.1 -1.4 2.5
Falls in the last year 0.4 0.5 0.9 -1.0 -0.4
Hair/balding pattern: Pattern 3 0.5 0.7 1.0 -0.6 -1.0
Number of live births 0.3 0.5 0.7 -0.9 -0.4
Forced expiratory volume in 1-second (FEV1) 5.5 18.4 24.6 5.0 -3.5
Pulse rate 1.0 1.7 2.0 -1.2 1.4
Happiness 0.8 0.9 1.8 -0.2 1.3
Noisy workplace 0.1 0.1 0.2 -0.5 0.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 -0.0 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.1 -0.3 0.0
Mouth/teeth dental problems: Dentures 2.1 3.5 5.9 -2.4 1.1
Asthma 5.1 10.0 12.5 -3.5 2.7
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 -0.1 0.5
Medication: Cholesterol lowering 0.8 1.2 2.4 0.0 1.5
Depression (self-reported) 2.4 2.8 5.2 2.3 -0.7
Medication: Lansoprazole 2.1 2.4 4.3 2.1 0.7
Prospective memory result 0.1 0.2 0.2 -0.5 -0.3
Lung cancer (father) 0.0 0.0 0.0 -0.1 0.1
Illnesses of mother 0.6 0.8 0.9 0.8 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 4.9 15.7 16.6 4.1 -3.8
Pulse wave Arterial Stiffness index 1.2 1.4 2.4 -0.7 -1.5
Impedance of arm (left) 2.2 10.1 17.2 -1.7 -4.1
Arm fat mass (right) 3.0 12.4 17.0 -2.8 4.1
Trunk predicted mass 0.6 3.3 5.9 0.8 2.4
Standing height 0.1 1.2 2.3 -0.4 -1.5
Length of working week for main job 0.1 0.1 0.1 -0.3 -0.3
Exposure to tobacco smoke at home 0.0 0.0 0.1 -0.1 -0.2
Breastfed as a baby 1.7 2.1 3.7 -1.9 0.8
Tense / ‘highly strung’ 0.3 0.5 0.8 0.9 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.2 8.5 -0.0 2.9
Hair/balding pattern: Pattern 4 0.1 0.3 0.5 -0.2 -0.7
Birth weight of first child 0.4 0.7 1.0 -0.7 -1.0
Peak expiratory flow (PEF) 0.6 1.3 1.6 1.0 -1.3
Pulse wave reflection index 3.5 4.3 8.6 -0.2 -2.9
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.4 0.6 1.2
Loud music exposure frequency 0.2 0.3 0.5 0.7 -0.2
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 0.1 -0.3
Mouth/teeth dental problems: Bleeding gums 2.3 3.0 4.2 -1.3 -2.1
Blood clot in the leg (DVT) 0.1 0.1 0.2 -0.1 0.4
Medication: Paracetamol 0.6 1.0 1.4 0.8 1.2
Headache pain in last month 0.3 0.4 0.9 0.9 -0.0
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 5.0 -0.1 -2.2
Glaucoma (self-reported) 0.5 0.6 1.0 -1.0 0.4
Gout (self-reported) 1.8 2.5 4.7 2.2 -0.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.5 0.7 1.2
Medication: Amlodipine 1.6 2.2 3.9 0.8 2.0
Medication: Ventolin 100micrograms inhaler 4.6 5.9 5.9 -2.4 2.4
Birth weight 0.3 0.7 1.2 -0.5 -1.1
Chronic bronchitis/emphysema (mother) 7.0 8.2 16.3 -0.2 4.0
High blood pressure (siblings) 0.1 0.1 0.1 0.3 0.2
Forced vital capacity (FVC), Best measure 5.6 20.5 27.0 5.2 -3.7
Body fat percentage 4.0 15.7 18.2 -4.3 3.6
Leg fat percentage (right) 5.7 20.5 22.4 -4.3 4.7
Arm fat-free mass (right) 1.1 5.4 10.8 0.1 3.3
Exposure to tobacco smoke outside home 2.0 2.7 4.3 -1.1 2.1
Comparative body size at age 10 1.0 2.8 5.4 2.3 -0.4
Number of full brothers 0.6 0.7 0.9 -0.7 0.9
Worry too long after embarrassment 0.6 0.9 1.5 1.2 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 5.2 -0.2 2.3
Wheeze or whistling in the chest in last year 9.9 17.7 22.8 -4.8 3.5
Number of children fathered 0.0 0.0 0.0 -0.2 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.2 1.1 -0.4
Age at first live birth 1.8 3.2 3.4 1.8 -1.8
Pulse wave peak to peak time 1.4 1.7 3.0 0.6 1.7
Health satisfaction 4.2 5.5 10.6 -0.5 3.3
Shortness of breath walking on level ground 3.4 4.1 8.0 -0.4 2.8
Qualifications: College or University degree 4.0 12.8 18.3 2.7 -4.3
Eye problems/disorders: None of the above 1.2 1.3 2.7 -1.6 -0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 -0.1 -0.3
Emphysema/chronic bronchitis 7.7 8.7 12.3 -3.5 2.2
Medication for pain relief, constipation, heartburn 2.1 3.5 6.9 0.4 -2.6
Neck or shoulder pain in last month 0.2 0.3 0.6 -0.8 0.2
Medication: Blood pressure 1.2 2.1 3.5 0.9 1.9
Angina (self-reported) 2.5 3.3 4.9 1.3 2.2
Migraine (self-reported) 1.1 1.3 2.3 -0.5 1.5
Medication: Ibuprofen 0.5 0.6 1.0 1.0 0.4
Medication: Allopurinol 0.9 1.2 2.2 1.5 -0.5
Medication: Omeprazole 3.0 3.6 7.0 -2.6 0.4
Medication: Seretide 50 evohaler 2.8 3.2 3.3 -1.8 1.8
Mean time to correctly identify matches 0.6 1.1 1.2 -1.1 -1.1
Heart disease (mother) 0.5 0.6 1.0 -0.3 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 1.7 -1.3 0.9
Whole body fat mass 3.2 13.4 14.5 -3.5 3.8
Leg fat mass (right) 4.0 15.7 21.6 -3.1 4.6
Arm predicted mass (right) 1.4 7.4 14.8 0.0 3.9
Pulse rate, automated reading 2.0 6.5 9.2 -1.9 3.0
Alcohol intake frequency. 0.7 1.7 3.0 0.6 1.7
Comparative height size at age 10 0.2 1.3 2.4 1.6 -0.4
Number of full sisters 2.7 3.3 6.3 0.4 2.5
Suffer from ‘nerves’ 0.0 0.0 0.0 -0.2 0.1
Overall health rating 3.4 7.3 11.5 -1.8 3.4
Chest pain or discomfort 1.4 2.0 2.5 -1.2 1.6
Had major operations 1.1 1.3 1.6 1.2 1.0
Age at last live birth 2.0 3.0 5.0 1.0 -2.2
Family relationship satisfaction 0.7 0.8 0.9 0.9 1.0
Leg pain on walking 1.3 1.6 3.2 -0.2 1.8
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.5 -1.6 0.3
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 2.3 2.8 3.6 1.9 -1.4
Medication: Aspirin 1.7 2.3 4.2 -0.6 2.1
Supplements: Vitamin C 0.0 0.0 0.0 -0.2 0.1
Knee pain experienced in last month 1.4 2.2 4.4 -2.1 0.1
Hypertension (Self-reported) 2.6 7.1 14.3 0.0 3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 0.2 0.8
Illnesses of father: Heart disease 1.2 1.7 3.3 1.8 0.4
Illnesses of siblings: Diabetes 3.4 4.2 8.0 -2.8 0.6
Smoking status: Previous 0.2 0.3 0.3 -0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.9 3.9 6.3 -1.2 2.5
Whole body fat-free mass 0.7 4.0 7.8 0.4 2.8
Leg fat-free mass (right) 0.5 2.6 5.3 0.1 2.3
Arm fat percentage (left) 2.5 9.9 10.4 -3.1 3.2
Average weekly red wine intake 0.0 0.0 0.0 -0.2 -0.0
Handedness (chirality/laterality): Left-handed 0.6 0.7 0.7 -0.9 0.8
Mood swings 0.5 0.9 1.6 0.5 1.3
Loneliness, isolation 0.3 0.4 0.8 -0.1 0.9
Long-standing illness, disability or infirmity 6.0 9.1 10.2 -2.8 3.2
Ever had bowel cancer screening 3.9 4.5 8.4 -0.8 -2.9
Diabetes diagnosed by doctor 3.0 5.0 6.4 -1.9 2.5
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 0.1 -0.8
Friendships satisfaction 0.7 0.8 1.1 0.8 1.1
Qualifications: nursing, teaching 0.5 0.8 1.0 1.0 -0.8
Commuting to job workplace: Walk 1.1 1.1 1.6 -0.8 1.3
Eye problems/disorders: Cataract 1.0 1.2 1.7 1.3 0.8
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 3.0 1.7 -1.6
Medication for cholesterol 1.9 2.9 5.8 0.1 -2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.6 0.0 0.8
Back pain experienced in last month 0.5 0.7 0.9 -0.9 0.7
Mineral and other dietary supplements 0.2 0.2 0.3 0.6 0.4
Breast cancer (self-reported) 1.6 1.9 3.3 0.7 -1.8
Asthma (self-reported) 4.9 9.7 12.2 -3.5 2.7
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.2 -0.4
Osteoarthritis (self-reported) 0.6 0.8 1.3 -1.2 0.6
Medication: Aspirin 1.1 1.4 2.6 -0.5 1.6
Medication: Gliclazide 1.5 1.7 3.5 -0.0 1.9
Illnesses of father: None of the above (group 1) 0.2 0.2 0.2 0.5 -0.5
Smoking status: Current 6.9 10.9 11.7 -3.4 3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.2 19.4 20.3 4.5 -4.3
Whole body water mass 0.7 3.8 7.4 0.4 2.7
Leg predicted mass (right) 0.5 2.8 5.6 0.1 2.4
Arm fat mass (left) 2.7 11.2 15.1 -2.7 3.9
Number of self-reported non-cancer illnesses 3.8 6.6 7.1 -2.5 2.7
Average weekly champagne plus white wine intake 0.1 0.1 0.1 0.4 -0.3
Miserableness 1.0 1.7 2.2 1.5 1.1
Guilty feelings 0.2 0.3 0.5 -0.1 -0.7
Wears glasses or contact lenses 2.1 2.4 4.7 0.3 -2.2
Ever taken oral contraceptive pill 1.2 1.4 2.5 -1.6 0.5
Hearing aid user 1.2 1.4 2.3 -1.5 0.7
Mother’s age at death 1.5 1.9 2.8 -1.0 -1.7
Financial situation satisfaction 1.5 1.8 2.8 0.9 1.7
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.1 0.7
Commuting to job workplace: Public transport 0.9 1.1 2.1 -1.4 0.1
Eye problems/disorders: Glaucoma 0.2 0.3 0.3 -0.5 -0.6
Medication: Blood pressure 3.2 6.2 11.7 -0.8 3.4
Pain type(s) experienced in last month: Hip pain 1.3 1.7 1.8 -1.2 1.4
Supplements: Fish oil (including cod liver oil) 0.5 0.7 0.8 -0.9 0.7
High cholesterol (Self-reported) 0.7 1.2 2.2 -0.5 1.5
Medication: Bendroflumethiazide 1.7 2.5 4.0 1.1 2.0
Medication: Paracetamol 0.8 1.2 2.3 1.5 0.3
Medication: Lisinopril 1.3 1.6 2.8 0.6 1.7
Medication: Atorvastatin 1.8 2.2 3.4 1.0 1.8
Illnesses of father: High blood pressure 0.5 0.6 0.6 -0.8 0.8
Alcohol drinker status: Never 0.8 0.9 1.7 -0.4 1.3
Ever smoked 0.5 0.9 1.2 -1.1 0.8
Basal metabolic rate 1.0 5.7 11.2 -0.3 3.4
Leg fat percentage (left) 5.7 20.6 21.6 -4.4 4.6
Arm fat-free mass (left) 1.3 6.7 13.2 -0.4 3.6
Number of operations (self-reported) 1.7 2.6 4.7 0.7 2.2
Average weekly beer plus cider intake 0.5 0.7 1.3 0.3 1.1
Irritability 0.5 0.8 1.5 -1.2 0.4
Risk taking 1.2 1.8 3.0 0.7 -1.7
Ever had prostate specific antigen (PSA) test 1.4 1.7 1.8 1.3 -1.2
Fractured/broken bones in last 5 years 2.6 3.4 5.2 -1.2 2.3
Age started oral contraceptive pill 1.8 2.2 4.0 0.7 -2.0
Diastolic blood pressure, automated reading 3.2 10.0 16.9 -1.8 4.1
Ever depressed for a whole week 0.5 0.7 0.8 0.9 0.7
Unable to work because of sickness or disability 4.7 6.1 11.8 -0.6 3.4
Commuting to job workplace: Cycle 0.8 0.9 1.6 1.3 -0.4
Myopia 0.6 0.9 1.6 0.3 -1.3
Vascular/heart problems diagnosed by doctor 2.2 6.1 11.8 0.5 -3.4
Cholesterol lowering medication 0.6 0.9 1.8 0.1 1.3
Medication: Omeprazole (e.g. Zanprol) 4.2 5.1 8.7 -3.0 1.3
Pain experienced in last month 1.0 1.6 1.9 1.4 -1.1
Supplements: Calcium 0.4 0.5 1.0 -1.0 -0.1
Basal cell carcinoma (self-reported) 0.7 0.9 1.5 0.5 -1.2
Heart attack/myocardial infarction (self-reported) 1.4 1.9 2.3 1.2 1.5
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 -0.1 0.2
Heart disease (siblings) 0.5 0.6 1.0 1.0 0.5
Alcohol drinker status: Previous 0.4 0.4 0.6 -0.4 0.8
Pack years of smoking 6.9 10.1 12.6 -2.8 3.6
Impedance of whole body 1.8 9.0 11.9 -2.5 -3.5
Leg fat mass (left) 4.1 15.9 22.4 -3.1 4.7
Arm predicted mass (left) 1.4 7.0 13.8 -0.3 3.7