Hub : Genes

CTD-3195I5.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0927	0.0450	0.0075	-0.002	NA	0.018	NA	0.010	0.48	NA	0.019	NA	0.06
2	METSIM	Adipose	0.0553	0.0235	0.0027	-0.002	0.015	0.003	0.015	-0.002	0.95	0.0021	0.110	0.0024	0.99

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2018)	0.3	0.5	0.7	0.9	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.4	2.4	1.6	-0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	-0.2	-0.8
Depression (Nagel 2018)	0.5	0.8	1.2	-0.5	1.1
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	0.1	-0.1
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.2
Schizophrenia (2018)	0.5	0.9	1.8	1.3	-0.3
Schizophrenia vs Biploar Disorder	1.7	2.2	2.6	-1.6	1.4
Worry (Nagel 2018)	0.5	1.1	2.2	1.5	0.1
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	0.8	-1.3
Alzheimer’s Disease (in father)	1.5	1.6	2.9	1.7	0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	0.8	0.9	-0.3
Crohns Disease (2017)	0.0	0.1	0.2	0.4	-0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	-0.3	0.5
Ulcerative Colitis (UC)	0.4	0.7	0.7	-0.8	0.8
Major Depression (MDD)	0.1	0.2	0.3	-0.5	-0.2
Reaction Time	0.4	0.7	0.8	0.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.0	-1.0	0.5
Breast Cancer	0.7	1.7	2.7	-0.8	1.6
Ovarian Cancer	2.0	2.6	4.8	0.6	-2.2
Prostate Cancer	0.1	0.2	0.2	0.3	-0.5
Age at First Birth	0.4	0.6	1.3	0.1	-1.1
Bipolar Disorder (2011)	0.6	0.6	1.1	0.0	1.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	0.6	0.4
Coronary Artery Disease (CAD)	0.5	0.6	0.9	-0.9	0.6
Crohns Disease (2012)	0.1	0.1	0.1	0.2	0.4
Mean Putamen Volume	0.5	0.6	0.9	1.0	0.5
Fasting Glucose	0.4	0.5	0.8	-0.9	0.4
HbA1C	1.2	1.4	1.5	1.2	-1.1
HDL Cholesterol	1.2	2.0	2.9	-1.7	1.1
LDL Cholesterol	0.9	1.5	2.0	1.4	-0.9
Lupus	0.9	1.4	2.0	1.4	-0.9
Neuroticism (2016)	0.2	0.3	0.4	0.4	-0.6
Primary Biliary Cirrhosis	0.8	1.2	1.2	-1.1	1.1
Rheumatoid Arthritis	1.0	1.4	2.4	0.7	1.5
Schizophrenia (2014)	0.0	0.0	0.0	0.1	-0.1
Triglycerides	0.4	0.7	1.3	0.3	-1.1
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.3	0.5	-1.8
Ulcerative Colitis	1.2	1.7	3.4	-0.3	1.8
Blood Eosinophil Count	0.1	0.8	1.0	0.7	-1.0
Blood Platelet Count	0.2	2.5	3.0	-1.7	1.4
Blood Red Count	0.0	0.1	0.1	0.0	-0.4
Blood White Count	0.1	0.8	1.3	-0.5	1.1
Heel T-Score	0.2	1.6	2.7	1.6	-0.6
BMI	0.1	0.8	1.5	1.2	-0.4
Height	0.2	3.1	6.2	0.1	-2.5
Waist Hip Ratio (WHR)	2.5	11.1	15.8	4.0	-2.5
Systolic Blood Pressure	0.5	2.5	4.2	2.0	-0.9
Smoking Status	0.1	0.2	0.3	-0.0	0.6
Allergy or Eczema	0.7	1.8	3.6	0.0	-1.9
Cardiovascular Disease	0.6	1.9	2.0	1.3	-1.4
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.1	0.3
Respiratory disease	0.3	0.6	0.9	-1.0	0.6
Type 2 Diabetes (T2D) (2018)	2.5	4.7	5.4	2.0	-2.3
Lung FEV1/FVC ratio	5.1	25.7	27.1	5.2	-4.9
Lung FVC	0.6	3.1	5.5	-2.4	0.9
Neuroticism	0.0	0.0	0.1	0.2	-0.1
Chronotype (morning person)	0.5	1.1	2.1	1.5	-0.2
Hair Pigment	0.0	0.6	1.0	1.0	-0.4
Tanning	0.0	0.1	0.1	-0.3	0.2
Hand grip strength (left)	0.9	2.5	4.8	-0.4	2.2
Number of treatments/medications taken	0.5	1.0	1.5	-0.7	-1.2
Average weekly spirits intake	0.5	0.6	1.2	-1.1	0.1
Sensitivity / hurt feelings	0.1	0.1	0.2	0.4	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	0.4	0.3
Hearing difficulty/problems: Yes	0.4	0.7	1.2	-0.3	-1.1
Relative age of first facial hair	0.2	0.3	0.7	0.8	0.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.5	-0.1	-1.6
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.9	-1.7	-0.4
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	0.2	-1.2
Systolic blood pressure, automated reading	0.2	0.6	0.8	0.6	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.3	0.0	-1.1
Angina	0.5	0.7	1.2	-1.1	0.4
Medication for hormone replacement therapy	0.6	0.7	1.3	-1.1	0.2
Vitamin and mineral supplements	0.2	0.3	0.5	0.3	0.7
Supplements: Zinc	0.3	0.4	0.6	-0.4	0.8
Medication: Co-codamol	1.4	1.6	2.9	1.7	-0.5
Medication: Metformin	0.6	0.8	1.6	-0.1	-1.3
Diabetes (father)	1.7	2.1	2.9	1.7	-1.2
Diabetes (mother)	0.8	1.1	1.6	1.3	0.7
Severe depression (siblings)	0.7	0.8	1.2	-0.7	1.1
Pack years adult smoking proportion	0.0	0.0	0.1	-0.3	-0.2
Impedance of leg (right)	0.5	2.6	3.0	1.5	-1.7
Leg fat-free mass (left)	0.0	0.1	0.1	-0.2	-0.3
Trunk fat percentage	0.3	1.3	2.3	0.5	-1.5
Hand grip strength (right)	0.8	2.3	4.2	-0.6	2.1
Townsend deprivation index at recruitment	0.5	0.8	1.4	1.2	-0.3
Current tobacco smoking	0.6	1.1	1.7	1.3	0.6
Average weekly fortified wine intake	0.5	0.6	0.9	0.5	-1.0
Maternal smoking around birth	0.9	1.4	2.7	-0.2	1.6
Fed-up feelings	0.1	0.1	0.2	0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.3	-0.5	1.5
Relative age voice broke	1.1	1.6	2.4	1.6	-0.9
Taking other prescription medications	0.1	0.2	0.3	0.0	-0.6
Age when periods started (menarche)	1.8	4.3	8.3	-2.9	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.7	0.4
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.6	0.2
Serious illness, injury or assault to yourself	0.9	1.1	1.8	-0.6	1.4
High blood pressure	1.6	4.3	7.2	1.2	-2.7
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.4	0.5	-1.9
Multivitamins +/- minerals	0.8	1.0	1.9	-0.3	-1.4
Stomach or abdominal pain in last month	0.7	0.8	1.4	-1.2	0.5
Supplements: Glucosamine	0.7	0.8	1.3	-1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.8	-2.0	-0.0
Medication: Atenolol	3.1	3.9	7.7	-0.2	-2.8
Medication: Levothyroxine sodium	0.3	0.5	0.6	-0.6	-0.8
Sitting height	0.0	0.3	0.5	-0.7	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.1	0.7
High blood pressure (mother)	0.7	1.0	1.7	0.6	1.3
Body mass index (BMI)	0.0	0.1	0.1	0.3	0.1
Impedance of leg (left)	0.5	2.6	4.3	1.0	-2.1
Leg predicted mass (left)	0.0	0.1	0.1	-0.3	-0.3
Trunk fat mass	0.3	1.3	2.4	0.4	-1.5
Waist circumference	0.6	2.0	2.6	1.2	-1.6
Number of incorrect matches in round	0.4	0.7	1.2	0.4	-1.1
Past tobacco smoking	0.0	0.0	0.0	-0.1	-0.1
Alcohol usually taken with meals	2.6	4.2	7.1	-2.7	-1.1
Nervous feelings	0.8	1.5	2.8	1.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	0.0	1.3
Hearing difficulty/problems with background noise	0.0	0.0	0.1	-0.3	-0.1
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	-0.5	0.8
Had menopause	0.0	0.0	0.0	0.2	0.1
Had other major operations	1.8	2.2	2.6	1.4	-1.6
Forced vital capacity (FVC)	0.2	0.9	1.2	-0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.7	0.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.9	0.4	-1.4
Qualifications: None of the above	0.5	1.1	1.8	0.7	1.3
Financial difficulties in last 2 years	0.7	0.9	1.4	0.6	1.2
Mouth/teeth dental problems	0.0	0.0	0.1	0.0	-0.2
Heart attack	0.3	0.3	0.6	-0.1	-0.8
Allergy	0.5	1.1	2.1	-0.3	1.4
Pain all over the body in last month	0.4	0.4	0.7	-0.8	0.3
Diabetes (self-reported)	0.9	1.4	2.7	0.4	-1.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	1.7	-1.1	-1.3
Medication: Ramipril	4.1	5.3	7.6	1.7	-2.7
Medication: Simvastatin	0.1	0.1	0.1	-0.3	0.3
Fluid intelligence score	0.0	0.1	0.1	-0.3	0.2
Illnesses of siblings	2.6	3.7	6.8	2.6	-0.7
Neuroticism score	0.2	0.3	0.7	0.8	-0.0
Weight	0.1	0.6	0.9	0.5	-0.9
Impedance of arm (right)	0.3	1.3	1.7	1.0	-1.3
Arm fat percentage (right)	0.2	0.6	0.8	0.9	-0.7
Trunk fat-free mass	0.0	0.2	0.4	-0.1	-0.6
Hip circumference	0.1	0.6	1.2	0.2	-1.1
Time employed in main current job	0.2	0.2	0.4	0.6	0.3
Alcohol intake versus 10 years previously	1.5	2.2	4.0	2.0	-0.7
Father’s age at death	0.9	1.2	2.1	-1.4	0.5
Worrier / anxious feelings	0.2	0.3	0.4	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.8	-1.9	0.4
Falls in the last year	1.2	1.6	3.0	-0.5	1.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.2	0.5
Number of live births	1.9	2.7	4.1	1.2	-2.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.9	0.3	-2.0
Pulse rate	1.0	1.7	3.3	1.8	-0.2
Happiness	2.3	2.8	3.1	-1.6	-1.8
Noisy workplace	1.0	1.3	2.5	1.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.6	-1.6	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.2	-0.4	0.5
Mouth/teeth dental problems: Dentures	0.2	0.4	0.5	-0.7	0.5
Asthma	0.0	0.1	0.1	-0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	-1.2	-0.4
Medication: Cholesterol lowering	0.0	0.0	0.0	0.1	0.0
Depression (self-reported)	1.2	1.5	1.6	-1.2	1.3
Medication: Lansoprazole	0.2	0.2	0.3	-0.6	-0.2
Prospective memory result	0.3	0.3	0.5	-0.3	-0.7
Lung cancer (father)	2.3	2.7	2.8	1.7	-1.6
Illnesses of mother	0.4	0.5	0.8	0.6	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.5	0.7	-1.9
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	0.8	0.3
Impedance of arm (left)	0.1	0.6	1.2	0.2	-1.1
Arm fat mass (right)	0.1	0.4	0.5	0.7	-0.6
Trunk predicted mass	0.0	0.2	0.3	-0.2	-0.6
Standing height	0.2	2.3	4.5	0.2	-2.1
Length of working week for main job	0.0	0.0	0.1	-0.0	-0.3
Exposure to tobacco smoke at home	0.7	0.8	1.2	1.1	-0.7
Breastfed as a baby	1.3	1.7	2.3	1.0	-1.5
Tense / ‘highly strung’	0.7	1.1	2.1	1.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	0.3	0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.6	0.3
Birth weight of first child	0.4	0.7	1.3	-0.3	-1.1
Peak expiratory flow (PEF)	0.5	1.2	2.4	0.2	-1.5
Pulse wave reflection index	0.8	1.0	1.7	1.3	-0.5
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.1	-0.0
Loud music exposure frequency	1.7	1.8	2.4	-1.6	-1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.7	-1.7	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	1.1	0.3
Blood clot in the leg (DVT)	0.3	0.4	0.4	0.6	0.7
Medication: Paracetamol	2.0	3.2	5.3	-2.3	1.1
Headache pain in last month	0.7	1.1	2.2	-1.5	0.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.1	-0.4	2.0
Glaucoma (self-reported)	0.2	0.2	0.4	-0.1	-0.6
Gout (self-reported)	0.3	0.4	0.7	0.3	0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.1	-0.5
Medication: Amlodipine	0.7	0.9	1.4	0.7	-1.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.0	0.2
Birth weight	0.3	0.7	1.3	0.4	-1.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.4	-1.2	-0.4
High blood pressure (siblings)	0.6	0.8	1.5	-1.2	0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	1.1	-0.6	-1.0
Body fat percentage	0.4	1.4	2.1	0.9	-1.4
Leg fat percentage (right)	0.6	2.3	3.0	1.7	-1.3
Arm fat-free mass (right)	0.1	0.4	0.5	-0.6	-0.7
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.3	0.5
Comparative body size at age 10	0.2	0.6	1.0	0.4	1.0
Number of full brothers	0.3	0.3	0.6	-0.8	0.3
Worry too long after embarrassment	0.2	0.3	0.5	-0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.9	0.5
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.3	0.3
Number of children fathered	2.3	2.6	4.3	2.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.2	-0.4	-0.4
Age at first live birth	0.0	0.1	0.1	0.1	-0.3
Pulse wave peak to peak time	0.5	0.6	0.8	-0.9	-0.6
Health satisfaction	1.7	2.2	4.3	-2.1	0.0
Shortness of breath walking on level ground	0.1	0.2	0.2	0.5	0.4
Qualifications: College or University degree	0.6	2.0	2.8	-1.1	-1.7
Eye problems/disorders: None of the above	0.7	0.8	1.6	1.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	-0.0
Emphysema/chronic bronchitis	0.9	1.0	1.8	-0.4	1.3
Medication for pain relief, constipation, heartburn	4.2	7.1	13.4	3.7	-0.9
Neck or shoulder pain in last month	1.3	1.9	2.3	-1.2	1.5
Medication: Blood pressure	1.7	3.0	5.7	0.5	-2.4
Angina (self-reported)	0.8	1.1	1.7	-1.3	0.7
Migraine (self-reported)	1.1	1.3	2.3	-0.6	1.5
Medication: Ibuprofen	0.7	0.8	0.8	-0.9	-0.9
Medication: Allopurinol	0.0	0.0	0.0	0.1	-0.0
Medication: Omeprazole	0.8	1.0	1.8	0.4	1.3
Medication: Seretide 50 evohaler	0.7	0.8	1.0	-0.8	1.0
Mean time to correctly identify matches	0.2	0.3	0.7	0.0	-0.8
Heart disease (mother)	1.6	1.9	3.3	-1.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	1.7	-1.3	1.1
Whole body fat mass	0.3	1.1	1.6	0.7	-1.3
Leg fat mass (right)	0.4	1.5	1.6	1.3	-1.2
Arm predicted mass (right)	0.1	0.6	0.7	-0.7	-0.9
Pulse rate, automated reading	0.6	1.9	3.6	1.9	-0.5
Alcohol intake frequency.	0.6	1.3	2.4	1.5	-0.5
Comparative height size at age 10	0.3	1.5	2.2	-0.9	-1.5
Number of full sisters	0.8	1.0	1.2	-1.1	0.9
Suffer from ‘nerves’	1.6	2.4	4.8	2.2	0.2
Overall health rating	1.8	3.9	7.4	-2.7	0.7
Chest pain or discomfort	0.9	1.3	2.5	-1.6	0.1
Had major operations	0.7	0.8	1.6	0.0	1.2
Age at last live birth	0.2	0.3	0.3	0.6	-0.5
Family relationship satisfaction	2.9	3.6	6.2	-1.0	-2.5
Leg pain on walking	0.1	0.1	0.2	0.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.6	1.9	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	-0.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	1.8	-1.4	-1.2
Medication: Aspirin	1.3	1.7	3.4	-1.8	0.1
Supplements: Vitamin C	0.4	0.5	0.9	-0.9	-0.2
Knee pain experienced in last month	0.3	0.5	1.0	1.0	0.0
Hypertension (Self-reported)	1.4	3.9	7.0	0.9	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.2	0.8
Illnesses of father: Heart disease	3.6	4.9	7.1	-2.7	1.7
Illnesses of siblings: Diabetes	0.1	0.2	0.3	0.5	0.3
Smoking status: Previous	0.4	0.6	0.9	-1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.1	-0.6
Whole body fat-free mass	0.0	0.1	0.2	-0.2	-0.5
Leg fat-free mass (right)	0.0	0.2	0.2	-0.5	-0.3
Arm fat percentage (left)	0.1	0.3	0.4	0.5	-0.7
Average weekly red wine intake	0.3	0.4	0.8	-0.9	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.3	0.4
Mood swings	0.2	0.4	0.8	-0.0	-0.9
Loneliness, isolation	0.0	0.0	0.0	0.2	-0.2
Long-standing illness, disability or infirmity	0.6	0.9	1.2	-1.1	-0.7
Ever had bowel cancer screening	5.2	6.1	11.4	-3.4	1.0
Diabetes diagnosed by doctor	2.2	3.7	5.7	1.3	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.2	0.1
Friendships satisfaction	1.5	1.9	2.4	-1.6	-1.1
Qualifications: nursing, teaching	0.3	0.5	1.0	0.1	-1.0
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.2	-0.2
Eye problems/disorders: Cataract	0.4	0.5	0.6	-0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.1	-0.8
Medication for cholesterol	0.2	0.3	0.4	0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.8	0.4
Back pain experienced in last month	1.3	1.8	3.7	-0.1	1.9
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	0.1
Breast cancer (self-reported)	1.4	1.7	1.7	1.3	-1.3
Asthma (self-reported)	0.0	0.1	0.1	-0.2	0.3
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.6	-0.1
Osteoarthritis (self-reported)	0.2	0.2	0.3	-0.4	-0.6
Medication: Aspirin	1.7	2.2	4.2	-2.1	-0.3
Medication: Gliclazide	2.0	2.2	4.0	0.7	-2.0
Illnesses of father: None of the above (group 1)	1.0	1.2	2.2	0.5	-1.5
Smoking status: Current	0.7	1.2	2.0	1.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.4	0.5	-1.6
Whole body water mass	0.0	0.2	0.2	-0.4	-0.5
Leg predicted mass (right)	0.0	0.2	0.3	-0.5	-0.2
Arm fat mass (left)	0.1	0.4	0.5	0.5	-0.7
Number of self-reported non-cancer illnesses	0.5	0.8	1.6	-0.2	-1.3
Average weekly champagne plus white wine intake	0.1	0.2	0.2	-0.4	-0.4
Miserableness	0.0	0.0	0.0	0.1	-0.0
Guilty feelings	0.0	0.1	0.1	0.3	-0.1
Wears glasses or contact lenses	0.8	0.9	1.1	-1.1	0.8
Ever taken oral contraceptive pill	1.2	1.3	2.2	1.5	0.7
Hearing aid user	0.2	0.2	0.5	0.1	0.7
Mother’s age at death	0.9	1.1	1.8	-1.3	0.6
Financial situation satisfaction	0.3	0.3	0.4	-0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.0	0.2
Commuting to job workplace: Public transport	4.1	4.9	9.6	-3.1	0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.1	0.6
Medication: Blood pressure	1.1	2.2	4.2	0.3	-2.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	1.6	1.1	1.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.3	-0.7
High cholesterol (Self-reported)	0.1	0.3	0.5	-0.1	0.7
Medication: Bendroflumethiazide	1.0	1.6	1.7	1.2	-1.3
Medication: Paracetamol	1.1	1.7	2.2	-1.5	1.1
Medication: Lisinopril	3.0	3.9	6.4	2.5	-1.2
Medication: Atorvastatin	1.2	1.5	2.6	-0.6	-1.6
Illnesses of father: High blood pressure	1.6	1.9	3.7	-0.4	1.9
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	0.2
Ever smoked	0.3	0.5	0.5	0.7	-0.6
Basal metabolic rate	0.0	0.2	0.3	-0.1	-0.6
Leg fat percentage (left)	0.5	1.8	1.9	1.3	-1.4
Arm fat-free mass (left)	0.1	0.6	0.8	-0.6	-0.9
Number of operations (self-reported)	1.0	1.4	2.3	-1.5	-0.8
Average weekly beer plus cider intake	0.6	0.9	0.9	1.0	0.9
Irritability	0.2	0.4	0.4	-0.6	-0.7
Risk taking	0.2	0.2	0.3	0.4	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	0.8	0.2
Fractured/broken bones in last 5 years	0.6	0.8	1.4	-1.2	0.5
Age started oral contraceptive pill	1.2	1.5	3.1	-1.8	-0.0
Diastolic blood pressure, automated reading	3.4	10.4	19.4	4.4	-1.2
Ever depressed for a whole week	1.8	2.2	2.5	1.4	-1.6
Unable to work because of sickness or disability	1.0	1.2	2.0	-0.7	1.4
Commuting to job workplace: Cycle	0.5	0.6	0.6	0.8	0.7
Myopia	0.4	0.5	1.0	-0.2	-1.0
Vascular/heart problems diagnosed by doctor	1.1	3.1	5.5	-0.8	2.3
Cholesterol lowering medication	0.3	0.5	0.7	-0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	0.5	1.3
Pain experienced in last month	0.6	0.9	1.8	0.3	-1.4
Supplements: Calcium	1.1	1.2	2.2	-1.5	0.5
Basal cell carcinoma (self-reported)	2.1	2.4	2.7	1.6	1.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.0	0.3	1.0
Heart disease (siblings)	0.8	0.9	1.8	-1.3	-0.3
Alcohol drinker status: Previous	0.2	0.3	0.5	0.1	-0.7
Pack years of smoking	0.2	0.2	0.3	-0.4	-0.5
Impedance of whole body	0.3	1.5	2.6	0.6	-1.6
Leg fat mass (left)	0.3	1.3	1.7	0.9	-1.3
Arm predicted mass (left)	0.1	0.3	0.7	-0.0	-0.8