Hub : Genes

FHOD3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1490	0.0400	7.9e-06	0.000	0.043	0.033	0.042	0.003	3.4e-01	5.0e-06	5.9e-05	6.3e-06	1.4e-01
2	GTEx	Muscle Skeletal	0.1480	0.0433	1.5e-04	0.045	NA	0.053	NA	0.054	2.7e-05	NA	6.4e-06	NA	4.7e-06
3	GTEx	Thyroid	0.1040	0.0470	8.4e-03	0.002	NA	-0.003	NA	-0.002	2.2e-01	NA	6.4e-01	NA	4.5e-01
4	TCGA	Prostate Adenocarcinoma	0.0775	0.0350	2.5e-03	0.005	0.020	0.019	NA	-0.001	9.1e-02	3.1e-03	4.1e-03	NA	3.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.4	1.0	0.4	-1.0	0.8	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	-0.4	-0.6	0.4	0.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	1.7	-0.7	1.0	-1.0
Depression (Nagel 2018)	1.3	1.9	4.4	1.1	1.5	-0.2	-2.1
Intelligence (Savage-Jansen 2018)	0.6	1.7	2.7	1.5	-1.1	0.9	-1.6
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.7	-1.0	0.1	-0.7
Schizophrenia (2018)	0.2	0.3	0.9	-0.9	-0.0	-0.1	0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	-0.1	-0.5	0.3	1.1
Worry (Nagel 2018)	0.2	0.5	1.6	-1.3	0.2	-0.3	-0.2
Alzheimer’s Disease (in mother)	0.5	0.5	2.0	0.3	-0.0	-0.0	1.4
Alzheimer’s Disease (in father)	1.1	1.2	3.8	-0.2	1.0	-0.3	1.9
Alzheimer’s Disease (including proxy)	0.9	1.3	4.5	-0.6	0.7	-0.3	2.1
Crohns Disease (2017)	0.3	0.6	1.1	0.7	-0.7	0.5	1.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.6	-0.2	0.6	0.2
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.3	0.7	0.6	-0.9
Major Depression (MDD)	0.8	1.0	3.5	-0.7	1.9	0.1	-0.0
Reaction Time	0.5	1.0	2.6	-1.6	0.0	-0.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.0	1.2	-0.9	-0.3	-1.4
Breast Cancer	0.7	1.6	4.1	0.0	-2.0	-0.4	1.5
Ovarian Cancer	0.5	0.7	2.4	0.2	-1.6	-0.3	-0.4
Prostate Cancer	0.5	0.6	1.6	1.3	-0.1	0.9	-0.4
Age at First Birth	0.6	0.9	3.0	0.6	-0.5	-1.7	0.2
Bipolar Disorder (2011)	0.6	0.6	1.6	-0.5	-0.2	-0.7	1.3
Body Mass Index (BMI) (2010)	0.6	0.9	2.5	0.5	-1.6	-0.7	0.4
Coronary Artery Disease (CAD)	0.7	0.8	1.8	-0.1	0.7	0.9	-1.3
Crohns Disease (2012)	0.3	0.4	1.2	0.6	-0.1	1.1	0.1
Mean Putamen Volume	1.7	2.0	6.2	-2.5	-0.6	-1.2	-0.3
Fasting Glucose	0.2	0.2	0.3	0.6	0.1	0.5	0.4
HbA1C	0.9	1.0	2.7	-0.1	1.6	1.1	0.6
HDL Cholesterol	0.7	1.1	2.5	1.6	0.3	0.7	-1.2
LDL Cholesterol	0.1	0.1	0.4	-0.3	-0.2	-0.6	-0.1
Lupus	0.4	0.7	1.6	0.8	-0.4	-1.3	-0.5
Neuroticism (2016)	0.4	0.6	1.5	0.7	-1.2	0.1	0.8
Primary Biliary Cirrhosis	0.4	0.6	1.5	0.4	-1.2	0.6	0.7
Rheumatoid Arthritis	0.4	0.5	1.3	1.1	-0.4	0.8	0.3
Schizophrenia (2014)	0.4	0.8	2.8	-1.7	0.6	-0.2	0.2
Triglycerides	0.1	0.2	0.4	0.6	0.7	0.4	0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	0.4	0.6	-1.2	1.0
Ulcerative Colitis	0.4	0.6	1.2	-0.1	0.8	0.9	-1.1
Blood Eosinophil Count	0.1	0.9	1.6	-1.3	0.9	-0.1	1.0
Blood Platelet Count	0.0	0.3	0.5	-0.5	0.5	0.4	-0.7
Blood Red Count	0.1	1.0	2.8	0.8	-0.2	1.7	-0.9
Blood White Count	0.1	0.7	1.7	-1.3	0.6	-0.2	-0.8
Heel T-Score	0.1	0.6	1.6	-0.4	0.6	0.3	-1.3
BMI	0.2	1.2	2.9	1.7	-0.7	-1.2	0.5
Height	0.0	0.4	0.8	0.4	0.7	-0.7	-0.9
Waist Hip Ratio (WHR)	1.5	6.7	18.9	-2.0	0.1	-4.3	2.0
Systolic Blood Pressure	0.1	0.7	1.3	-0.3	1.2	1.1	0.3
Smoking Status	0.1	0.2	0.3	0.6	-0.2	0.2	0.5
Allergy or Eczema	0.1	0.3	0.4	-0.6	0.7	0.6	-0.3
Cardiovascular Disease	0.3	1.1	1.9	-1.4	1.1	0.7	0.7
Hypothyroidism (self reported)	0.6	1.3	2.3	1.2	-0.8	1.0	-1.5
Respiratory disease	0.4	0.9	1.6	-0.3	0.6	-1.2	1.3
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.7	0.9	-0.6	0.3	1.6
Lung FEV1/FVC ratio	0.8	4.2	7.2	2.7	-2.7	0.5	-1.5
Lung FVC	1.6	8.2	15.8	-2.4	3.2	1.2	-4.0
Neuroticism	0.4	0.9	1.8	0.3	-1.3	1.3	-0.2
Chronotype (morning person)	0.3	0.6	2.2	-1.5	0.4	0.1	-0.1
Hair Pigment	0.0	0.4	1.0	-0.3	-1.0	0.3	-0.6
Tanning	0.2	1.9	3.7	1.9	-0.5	1.5	-1.2
Hand grip strength (left)	0.3	0.8	1.2	0.3	-1.0	1.0	-1.1
Number of treatments/medications taken	1.3	2.3	4.6	-1.4	0.9	-2.2	1.3
Average weekly spirits intake	1.3	1.6	3.3	-1.8	-0.1	-1.3	1.2
Sensitivity / hurt feelings	0.3	0.5	0.8	0.8	-0.9	0.7	0.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	5.3	1.4	1.2	0.5	-2.3
Hearing difficulty/problems: Yes	0.7	1.1	1.9	-1.4	0.6	0.3	1.4
Relative age of first facial hair	1.8	3.8	6.3	1.0	-1.5	-2.5	2.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.3	0.5	0.7	0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.6	-0.7	-1.6	-0.5	0.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	-0.2	-0.6	-0.7	-1.4
Systolic blood pressure, automated reading	0.2	0.5	2.0	0.1	0.3	-0.1	1.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.7	1.0	-1.9	-0.0	0.2
Angina	0.1	0.2	0.4	-0.0	0.6	-0.4	0.4
Medication for hormone replacement therapy	2.2	2.5	4.8	1.8	-2.2	0.9	-0.9
Vitamin and mineral supplements	0.2	0.3	0.7	-0.8	-0.1	-0.4	-0.4
Supplements: Zinc	1.1	1.2	4.4	-2.1	0.1	0.6	0.1
Medication: Co-codamol	0.3	0.4	0.7	0.5	0.3	-0.7	-0.8
Medication: Metformin	0.2	0.3	0.5	0.7	-0.6	0.2	0.7
Diabetes (father)	0.4	0.5	1.0	-1.0	-0.3	-0.9	0.4
Diabetes (mother)	0.2	0.3	0.5	-0.3	0.6	0.4	-0.7
Severe depression (siblings)	0.5	0.5	0.8	-0.9	-0.8	-0.4	0.7
Pack years adult smoking proportion	0.5	0.8	1.3	1.0	-0.6	1.1	0.7
Impedance of leg (right)	0.2	1.1	3.1	-1.0	0.3	0.2	-1.8
Leg fat-free mass (left)	0.2	1.3	4.2	2.0	0.5	0.3	-0.8
Trunk fat percentage	0.6	2.3	7.3	-0.6	0.5	-2.7	1.1
Hand grip strength (right)	0.7	2.0	4.3	1.2	-0.8	1.2	-2.1
Townsend deprivation index at recruitment	2.1	3.0	6.4	-2.3	2.5	0.5	-0.3
Current tobacco smoking	0.4	0.7	1.8	0.7	0.5	1.3	-0.6
Average weekly fortified wine intake	0.6	0.7	1.6	-1.0	-0.7	0.1	1.3
Maternal smoking around birth	0.2	0.3	0.5	-0.6	0.7	0.2	-0.6
Fed-up feelings	0.3	0.5	0.9	0.1	1.0	0.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	4.4	1.1	2.1	0.5	-2.1
Relative age voice broke	1.1	1.7	3.0	0.4	-1.3	-1.4	1.7
Taking other prescription medications	0.6	1.0	2.9	-0.3	0.6	-1.7	0.7
Age when periods started (menarche)	0.2	0.4	0.7	-0.6	-0.1	-0.8	0.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.5	-1.3	0.0	-1.9	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.1	-0.5	0.6	0.6	-1.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.9	-1.7	1.5	0.2	0.5
Qualifications: CSEs or equivalent	0.6	0.8	1.5	0.6	1.0	-1.2	-0.5
Serious illness, injury or assault to yourself	0.6	0.8	1.9	-0.5	1.4	-0.2	0.9
High blood pressure	0.8	2.3	6.5	-1.4	0.8	-0.1	2.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.9	0.6	-0.3	1.4	-0.5
Multivitamins +/- minerals	0.4	0.5	1.0	0.4	-0.0	1.0	0.9
Stomach or abdominal pain in last month	0.7	0.9	2.3	-1.5	0.7	-0.0	0.9
Supplements: Glucosamine	1.1	1.5	3.8	-1.3	-0.4	-1.9	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.1	0.8	0.5	1.7	-0.5
Medication: Atenolol	1.3	1.7	3.9	-1.1	2.0	-1.2	0.1
Medication: Levothyroxine sodium	0.5	0.9	2.3	1.5	-1.1	-0.1	-0.5
Sitting height	0.5	3.5	10.0	1.0	1.1	3.2	-1.3
Chronic bronchitis/emphysema (father)	2.1	2.4	8.9	0.1	-0.8	-0.5	3.0
High blood pressure (mother)	1.6	2.3	2.8	-1.2	1.7	1.5	-1.6
Body mass index (BMI)	0.2	0.8	2.5	1.6	-0.3	-0.6	0.7
Impedance of leg (left)	0.2	1.0	1.9	-1.4	0.4	-0.1	-1.4
Leg predicted mass (left)	0.2	1.3	4.3	2.1	0.4	0.2	-0.8
Trunk fat mass	0.2	1.0	3.0	0.4	0.6	-1.7	0.6
Waist circumference	0.2	0.9	3.0	0.3	-0.1	-1.7	0.6
Number of incorrect matches in round	0.5	0.8	1.1	-1.0	-0.1	1.0	1.0
Past tobacco smoking	1.0	1.8	4.3	-1.1	1.3	-0.4	-2.1
Alcohol usually taken with meals	0.3	0.4	1.6	-0.4	-1.3	-0.2	0.2
Nervous feelings	0.2	0.4	1.1	-0.1	-0.7	-0.3	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.7	-0.5	1.0	0.8	-1.3
Hearing difficulty/problems with background noise	0.4	0.6	1.7	-0.5	1.3	-0.0	0.8
Hair/balding pattern: Pattern 2	2.1	2.6	4.9	-2.2	2.1	-0.3	1.1
Had menopause	1.2	1.5	4.5	-0.9	-0.4	-0.9	2.1
Had other major operations	0.5	0.6	1.6	0.8	0.3	-1.3	-0.1
Forced vital capacity (FVC)	1.2	4.7	14.5	-0.6	1.8	0.9	-3.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	7.0	-0.3	0.7	0.1	-2.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	-1.4	-0.4	0.7	-0.0
Qualifications: None of the above	2.1	4.6	6.8	-2.2	2.6	-0.3	2.6
Financial difficulties in last 2 years	0.4	0.5	1.7	0.7	0.2	1.3	0.1
Mouth/teeth dental problems	0.5	0.8	2.6	0.4	-1.6	0.5	-0.3
Heart attack	0.8	1.0	2.9	-0.8	1.7	-0.1	-0.7
Allergy	0.0	0.1	0.2	-0.4	0.2	-0.2	-0.4
Pain all over the body in last month	3.6	3.9	9.3	-1.4	2.0	-3.1	0.2
Diabetes (self-reported)	1.6	2.4	4.2	2.0	-2.0	0.9	0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.1	-1.1	0.2	0.4	0.3
Medication: Ramipril	1.2	1.6	3.6	-1.9	0.4	-1.5	0.6
Medication: Simvastatin	0.6	0.9	1.7	-0.7	-0.3	-1.1	1.3
Fluid intelligence score	0.7	1.4	2.7	1.5	-0.8	-0.3	-1.6
Illnesses of siblings	1.5	2.2	5.7	2.4	-1.6	0.3	-0.7
Neuroticism score	0.3	0.7	1.3	0.8	-0.7	1.1	-0.7
Weight	0.2	1.0	3.6	1.9	0.4	-0.3	-0.4
Impedance of arm (right)	1.4	6.3	15.8	-4.0	0.9	-2.9	0.5
Arm fat percentage (right)	0.4	1.4	4.5	0.0	0.1	-2.1	1.0
Trunk fat-free mass	0.7	4.3	10.2	3.2	-0.0	2.0	-1.6
Hip circumference	0.1	0.2	0.6	0.5	0.1	0.1	-0.8
Time employed in main current job	0.9	1.0	3.5	0.6	-1.9	-0.3	0.2
Alcohol intake versus 10 years previously	0.5	0.7	1.4	1.1	-0.4	1.2	0.3
Father’s age at death	1.3	1.7	4.8	-1.1	-0.1	-2.2	1.0
Worrier / anxious feelings	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.9	1.0	-0.1	0.2	-0.9
Falls in the last year	1.0	1.4	3.4	-0.7	1.8	0.8	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	1.4	-1.1	-0.5	-0.4
Number of live births	0.9	1.2	4.2	0.5	-0.6	2.0	-0.1
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	15.8	0.5	1.0	0.7	-4.0
Pulse rate	1.5	2.6	5.1	1.3	-1.6	2.3	1.1
Happiness	0.4	0.5	1.2	0.4	-0.2	0.7	-1.1
Noisy workplace	1.6	1.9	5.9	-2.4	0.2	-1.2	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.9	6.2	0.6	-1.0	-0.0	-2.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.9	1.7	-1.2	0.2	0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.5	-0.6	0.8	-1.2	0.5
Asthma	0.1	0.2	0.5	0.2	-0.1	-0.5	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.9	0.4	0.4	0.9	-1.4
Medication: Cholesterol lowering	1.2	1.9	5.9	-0.8	-0.7	-0.9	2.4
Depression (self-reported)	0.6	0.7	1.6	-0.8	1.3	-0.7	0.5
Medication: Lansoprazole	1.9	2.1	3.3	-1.3	1.8	-1.0	-1.6
Prospective memory result	1.9	2.4	5.1	-0.9	-0.6	-1.8	2.3
Lung cancer (father)	0.2	0.3	0.5	0.4	-0.7	0.7	-0.0
Illnesses of mother	0.2	0.2	0.5	-0.0	0.3	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	17.0	0.2	0.5	1.0	-4.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.6	0.2	0.9	-0.0
Impedance of arm (left)	1.1	5.1	9.7	-3.1	0.8	-3.1	0.6
Arm fat mass (right)	0.1	0.5	1.2	0.9	0.4	-1.1	0.1
Trunk predicted mass	0.7	4.2	9.7	3.1	0.0	2.1	-1.7
Standing height	0.2	1.5	3.8	0.6	1.3	0.3	-2.0
Length of working week for main job	5.1	5.6	17.5	1.6	0.4	4.2	-1.4
Exposure to tobacco smoke at home	1.5	1.7	4.2	0.9	-1.3	-0.1	2.0
Breastfed as a baby	0.4	0.5	1.2	0.4	0.2	-1.1	-0.9
Tense / ‘highly strung’	0.8	1.4	3.7	-1.9	0.7	-0.2	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	-0.4	0.0	-0.2
Hair/balding pattern: Pattern 4	0.6	1.4	2.1	-0.5	-1.3	-1.5	1.2
Birth weight of first child	2.4	4.4	9.4	-3.1	1.3	-2.5	0.4
Peak expiratory flow (PEF)	0.4	0.9	2.3	1.0	0.1	0.6	-1.5
Pulse wave reflection index	0.4	0.5	1.0	-1.0	0.2	0.7	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	0.2	0.2	-0.3
Loud music exposure frequency	0.1	0.2	0.5	-0.1	0.7	-0.2	0.1
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	7.8	1.7	-0.3	-0.7	-2.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	-0.1	0.8	0.0	-1.3
Blood clot in the leg (DVT)	2.2	2.8	7.8	-1.3	0.6	-1.1	2.8
Medication: Paracetamol	0.2	0.4	0.9	-0.9	0.5	-0.6	0.2
Headache pain in last month	0.5	0.8	2.1	-0.9	-0.0	-0.5	-1.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	2.5	1.6	-1.6	0.3	-1.5
Glaucoma (self-reported)	0.9	1.1	3.3	-1.0	-1.8	-0.1	0.0
Gout (self-reported)	0.4	0.6	1.6	0.5	0.3	0.7	-1.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.8	1.7	-1.1	0.6	-1.4
Medication: Amlodipine	0.9	1.2	2.4	-1.5	0.7	-1.3	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-0.1	1.1	1.3	-0.1
Birth weight	0.0	0.1	0.2	0.0	-0.3	-0.0	0.5
Chronic bronchitis/emphysema (mother)	2.1	2.4	7.0	1.0	-0.2	-1.3	2.7
High blood pressure (siblings)	1.7	2.4	6.1	-2.5	0.8	0.0	1.7
Forced vital capacity (FVC), Best measure	1.2	4.3	13.8	-0.9	1.2	1.2	-3.7
Body fat percentage	0.4	1.4	4.8	-0.3	0.3	-2.2	0.8
Leg fat percentage (right)	0.1	0.3	1.0	1.0	-0.0	-0.5	-0.1
Arm fat-free mass (right)	0.9	4.4	11.0	3.3	-0.1	1.9	-1.8
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.6	-0.3	-0.0	0.4
Comparative body size at age 10	1.4	4.0	8.3	2.9	0.8	2.1	-1.6
Number of full brothers	2.3	2.8	6.3	-2.5	1.1	-1.7	-1.1
Worry too long after embarrassment	0.5	0.8	2.3	-0.6	-0.6	-1.5	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.9	-1.1	-1.0	-0.5	1.4
Wheeze or whistling in the chest in last year	2.1	3.8	11.7	-1.5	0.3	-1.0	3.4
Number of children fathered	0.7	0.8	2.3	1.5	-0.4	0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	0.4	1.6	0.4	0.3
Age at first live birth	0.4	0.7	2.0	0.2	-1.4	-0.5	0.6
Pulse wave peak to peak time	0.3	0.3	0.7	0.6	0.1	-0.8	-0.3
Health satisfaction	0.2	0.3	0.5	0.5	0.7	0.4	-0.4
Shortness of breath walking on level ground	0.2	0.2	0.4	0.1	-0.4	-0.7	0.5
Qualifications: College or University degree	0.7	2.1	2.5	1.4	-1.6	1.6	-1.1
Eye problems/disorders: None of the above	3.0	3.5	8.9	3.0	0.3	0.7	-2.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-0.3	-0.8	-0.9	1.1
Emphysema/chronic bronchitis	2.4	2.7	4.9	-2.1	0.7	-2.2	0.9
Medication for pain relief, constipation, heartburn	1.5	2.6	5.5	2.3	-1.4	1.5	-0.7
Neck or shoulder pain in last month	0.6	0.8	1.7	-0.7	0.6	-1.3	0.9
Medication: Blood pressure	2.0	3.5	9.6	-2.0	3.1	-0.4	0.2
Angina (self-reported)	0.1	0.1	0.2	-0.0	0.4	-0.4	0.5
Migraine (self-reported)	0.8	0.9	3.3	-1.8	0.3	-0.3	-0.4
Medication: Ibuprofen	0.5	0.7	0.9	-0.0	0.9	0.9	-1.0
Medication: Allopurinol	0.3	0.4	0.7	0.8	0.2	-0.6	-0.6
Medication: Omeprazole	1.3	1.5	3.1	-1.3	1.7	-1.2	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.2	-0.4	-0.8	0.2
Mean time to correctly identify matches	2.1	4.1	11.4	-3.4	0.5	-2.0	0.8
Heart disease (mother)	0.8	1.0	3.1	1.8	-0.8	-0.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.1	1.5	0.1	1.3	1.0
Whole body fat mass	0.1	0.6	1.3	0.8	0.5	-1.2	0.2
Leg fat mass (right)	0.1	0.6	1.8	1.3	0.5	-0.1	-0.4
Arm predicted mass (right)	0.8	3.9	11.2	3.4	-0.2	1.5	-1.5
Pulse rate, automated reading	3.0	9.6	26.1	2.6	-1.9	5.1	1.3
Alcohol intake frequency.	0.7	1.6	3.0	-0.8	0.0	-1.7	1.7
Comparative height size at age 10	0.5	2.7	8.4	0.3	2.9	-0.1	-1.5
Number of full sisters	0.5	0.6	1.2	0.0	-0.3	-1.1	1.1
Suffer from ‘nerves’	0.3	0.4	1.0	0.7	-0.3	0.5	-1.0
Overall health rating	0.2	0.4	1.4	0.4	0.1	-1.2	-0.4
Chest pain or discomfort	2.1	3.1	6.1	-2.5	0.3	-2.0	1.5
Had major operations	0.6	0.7	1.1	1.1	0.7	0.3	-1.0
Age at last live birth	0.8	1.2	2.8	-0.8	-1.7	0.5	1.0
Family relationship satisfaction	0.3	0.4	0.8	-0.0	-0.9	0.1	-0.8
Leg pain on walking	0.9	1.1	3.1	-1.8	0.9	-0.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.6	1.4	0.8	-0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.6	0.8	-1.9	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.7	-0.5	-0.1	-1.1
Medication: Aspirin	2.3	3.1	5.4	-2.3	1.4	-1.3	1.8
Supplements: Vitamin C	1.3	1.5	3.1	-1.8	0.6	-0.4	1.5
Knee pain experienced in last month	0.2	0.4	1.5	-0.0	-0.3	-0.0	1.2
Hypertension (Self-reported)	0.9	2.5	5.5	-1.9	1.0	-0.2	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	-0.7	-0.1	-0.2	1.5
Illnesses of father: Heart disease	2.0	2.8	4.3	2.1	-1.8	1.1	-1.5
Illnesses of siblings: Diabetes	0.3	0.4	1.1	-1.0	0.4	0.1	-0.7
Smoking status: Previous	1.2	1.8	6.0	-0.3	-1.0	-0.5	2.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.4	1.8	-0.8	-0.5	-0.6
Whole body fat-free mass	0.5	2.9	7.6	2.8	0.2	1.4	-1.5
Leg fat-free mass (right)	0.2	1.1	3.8	2.0	0.4	0.2	-0.6
Arm fat percentage (left)	0.4	1.6	5.1	0.3	0.1	-2.3	1.1
Average weekly red wine intake	1.0	1.4	4.3	-0.5	-1.1	-2.1	-0.2
Handedness (chirality/laterality): Left-handed	1.9	2.3	5.9	-0.9	2.4	1.2	-1.0
Mood swings	1.3	2.3	4.9	2.0	-0.4	2.2	-0.6
Loneliness, isolation	0.5	0.6	1.7	1.3	-0.4	-0.8	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	1.1	1.0	0.4	-0.6	0.3
Ever had bowel cancer screening	1.5	1.7	4.8	-2.2	-0.2	-1.0	1.0
Diabetes diagnosed by doctor	0.5	0.9	1.4	1.0	-1.0	0.5	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-1.5	0.3	-0.4	1.1
Friendships satisfaction	1.5	1.9	3.6	0.3	-1.9	-1.1	-1.5
Qualifications: nursing, teaching	0.7	1.1	2.2	0.1	-1.5	-1.1	-0.9
Commuting to job workplace: Walk	1.0	1.0	3.5	-1.9	-0.1	0.6	-0.6
Eye problems/disorders: Cataract	1.8	2.1	3.1	-1.6	0.8	-1.8	1.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	5.2	0.2	0.4	0.6	2.3
Medication for cholesterol	0.3	0.4	0.8	-0.8	0.9	-0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	-0.7	0.1	-1.5	-0.7
Back pain experienced in last month	0.5	0.7	1.6	-0.6	1.3	-1.0	0.2
Mineral and other dietary supplements	0.9	1.2	2.8	1.7	-1.1	0.9	-0.3
Breast cancer (self-reported)	0.4	0.5	0.9	1.0	0.6	-0.5	0.7
Asthma (self-reported)	0.1	0.3	0.7	0.2	0.2	-0.8	0.6
Osteoporosis (self-reported)	0.7	0.9	2.9	1.7	-0.3	0.7	0.4
Osteoarthritis (self-reported)	0.6	0.8	1.7	-0.2	0.8	-1.3	0.9
Medication: Aspirin	3.0	3.9	7.4	-2.7	1.8	-1.3	1.7
Medication: Gliclazide	0.4	0.5	1.3	0.1	-1.2	0.5	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.2	0.3	0.0	-1.1
Smoking status: Current	0.6	1.0	1.6	1.2	0.3	1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	10.2	-0.1	1.9	0.7	-3.2
Whole body water mass	0.5	2.8	7.3	2.7	0.2	1.4	-1.4
Leg predicted mass (right)	0.2	1.0	3.7	1.9	0.3	0.2	-0.5
Arm fat mass (left)	0.2	0.6	1.3	0.9	0.3	-1.2	0.5
Number of self-reported non-cancer illnesses	2.1	3.7	7.4	-2.2	1.2	-1.0	2.7
Average weekly champagne plus white wine intake	0.6	0.8	1.6	1.3	-1.2	0.6	0.2
Miserableness	0.5	0.9	2.8	1.7	-0.8	-0.0	-0.2
Guilty feelings	0.9	1.3	1.9	1.3	-1.4	0.6	-1.2
Wears glasses or contact lenses	1.1	1.3	3.2	-1.1	-0.1	-0.9	1.8
Ever taken oral contraceptive pill	0.9	1.0	2.0	1.4	0.0	1.4	0.3
Hearing aid user	0.8	0.9	1.5	-1.2	-1.0	-1.0	0.3
Mother’s age at death	0.7	0.9	3.1	0.0	-0.4	-0.6	1.8
Financial situation satisfaction	0.8	1.0	1.4	1.2	0.5	1.1	-1.1
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.8	-0.8	-0.8	-1.9	1.6
Commuting to job workplace: Public transport	1.1	1.4	2.3	0.5	1.1	1.3	-1.5
Eye problems/disorders: Glaucoma	0.9	1.1	2.7	-1.2	-1.6	-0.6	0.1
Medication: Blood pressure	1.0	2.0	4.0	0.0	-0.8	-1.8	2.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.5	0.0	0.6	0.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.4	-1.0	2.1	-0.9	-0.3
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.1	-0.1	-0.4	0.6
Medication: Bendroflumethiazide	0.3	0.5	0.9	0.5	0.9	0.9	-0.1
Medication: Paracetamol	0.3	0.5	0.9	-0.9	0.3	-0.7	0.8
Medication: Lisinopril	0.6	0.7	2.6	0.4	0.1	-0.4	1.6
Medication: Atorvastatin	0.9	1.2	2.4	-0.1	1.5	-0.7	-1.3
Illnesses of father: High blood pressure	1.1	1.4	3.6	1.9	-0.8	0.7	-1.0
Alcohol drinker status: Never	1.0	1.3	2.9	0.2	-0.6	-1.7	1.3
Ever smoked	1.1	1.9	2.5	1.5	-1.6	0.6	1.6
Basal metabolic rate	0.4	2.5	7.3	2.7	0.2	1.0	-1.2
Leg fat percentage (left)	0.1	0.3	0.7	0.7	0.1	-0.8	0.2
Arm fat-free mass (left)	0.5	2.7	6.3	2.5	0.3	1.7	-1.2
Number of operations (self-reported)	0.2	0.3	1.0	1.0	0.1	0.0	-0.2
Average weekly beer plus cider intake	1.0	1.4	4.5	-0.4	2.1	-0.3	-1.0
Irritability	0.9	1.5	2.5	1.4	-1.6	1.1	0.6
Risk taking	0.8	1.2	2.7	-0.5	1.6	0.2	1.3
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.0	0.4	-1.9	-1.4	2.2
Fractured/broken bones in last 5 years	1.1	1.4	2.7	0.2	-0.9	1.6	1.4
Age started oral contraceptive pill	1.9	2.4	4.2	-1.8	-0.4	-1.3	2.1
Diastolic blood pressure, automated reading	0.7	2.1	4.7	2.2	-0.9	1.0	1.4
Ever depressed for a whole week	1.7	2.1	7.2	-0.8	0.2	2.7	-0.8
Unable to work because of sickness or disability	0.5	0.7	2.4	1.5	0.3	-0.5	-0.1
Commuting to job workplace: Cycle	0.4	0.5	0.9	0.6	0.7	0.5	-0.9
Myopia	0.2	0.3	0.6	0.7	0.6	0.6	0.1
Vascular/heart problems diagnosed by doctor	1.1	3.1	6.9	1.7	-1.4	-0.5	-2.6
Cholesterol lowering medication	0.2	0.2	0.8	-0.1	-0.0	-0.9	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	2.6	-1.4	1.6	-1.2	-0.1
Pain experienced in last month	1.4	2.3	5.0	2.2	-1.1	1.6	-0.6
Supplements: Calcium	1.3	1.4	4.5	1.1	-2.1	0.1	0.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	0.6	-0.4	1.2	-0.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.3	-0.8	1.8	-0.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	8.3	-1.3	0.1	-1.1	2.9
Heart disease (siblings)	1.4	1.8	4.5	-1.1	2.1	0.0	-1.1
Alcohol drinker status: Previous	0.6	0.6	1.3	-1.1	0.6	-1.0	-0.2
Pack years of smoking	0.4	0.6	1.8	0.3	-0.4	0.7	1.3
Impedance of whole body	0.6	2.9	7.6	-2.8	0.5	-1.9	0.1
Leg fat mass (left)	0.1	0.4	1.3	1.2	0.5	-0.3	-0.2
Arm predicted mass (left)	0.7	3.5	8.9	3.0	0.1	1.7	-1.5