Hub : Genes

GALNT16

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.24 0.086 0.00630 0.220 NA 0.125 NA 0.244 2.4e-06 NA 4.3e-04 NA 6.0e-07
2 GTEx Esophagus Muscularis 0.15 0.055 0.00450 -0.002 NA -0.002 NA -0.001 4.5e-01 NA 4.4e-01 NA 3.7e-01
3 GTEx Muscle Skeletal 0.12 0.038 0.00004 0.027 NA 0.053 NA 0.055 1.1e-03 NA 5.5e-06 NA 4.1e-06
4 GTEx Skin Not Sun Exposed Suprapubic 0.12 0.050 0.00230 -0.002 NA 0.027 NA 0.002 4.3e-01 NA 1.2e-02 NA 2.3e-01
5 GTEx Spleen 0.26 0.107 0.00740 0.037 NA -0.004 NA 0.041 4.0e-02 NA 4.3e-01 NA 3.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Alzheimer’s Disease (in mother) 0.5 0.6 2.1 0.5 -0.4 -0.7 -0.2 -1.5
Alzheimer’s Disease (in father) 1.3 1.4 4.1 -0.6 -2.0 -1.6 -0.3 -0.4
Alzheimer’s Disease (including proxy) 1.1 1.5 3.1 0.2 -1.7 -1.6 -0.3 -1.3
Crohns Disease (2017) 0.7 1.5 2.4 -1.3 -1.5 -1.1 -1.5 0.2
Irritable Bowel Disease (IBD) 0.4 0.9 2.5 -0.5 -1.6 -0.7 0.3 1.1
Ulcerative Colitis (UC) 0.5 0.9 1.8 0.1 -1.0 -0.5 1.1 1.4
Major Depression (MDD) 0.8 0.9 1.7 -0.4 -1.0 -1.3 -1.2 0.6
Reaction Time 0.6 1.1 2.8 -1.7 0.3 -0.7 -1.5 -0.4
Verbal and Numeric Reasoning (VNR) 1.3 3.2 13.7 -0.4 0.5 0.3 1.4 -3.7
Breast Cancer 0.2 0.4 0.9 0.7 -1.0 -0.3 -0.0 -0.8
Ovarian Cancer 0.9 1.2 6.1 0.1 0.0 0.2 -0.2 -2.5
Prostate Cancer 1.6 2.3 4.1 2.0 1.5 2.0 1.2 -0.3
Age at First Birth 0.3 0.4 1.2 -0.2 0.7 0.4 -0.6 -1.1
Bipolar Disorder 1.6 1.6 2.4 1.1 1.6 1.4 1.5 -0.2
Body Mass Index (BMI) (2010) 1.8 2.6 3.9 -1.4 -1.5 -2.0 1.6 1.5
Coronary Artery Disease (CAD) 0.6 0.7 2.4 0.5 1.6 0.2 0.7 -0.7
Crohns Disease (2012) 0.1 0.2 0.4 -0.4 0.3 -0.2 0.6 -0.7
Mean Putamen Volume 0.5 0.6 1.3 0.3 0.6 0.1 1.2 -1.1
Fasting Glucose 0.2 0.2 0.4 0.1 -0.4 0.4 0.6 -0.6
HbA1C 0.6 0.7 1.4 0.2 -0.9 -1.1 -0.2 -1.2
HDL Cholesterol 0.3 0.4 1.0 -0.5 -0.3 -1.0 -0.9 0.4
LDL Cholesterol 0.1 0.2 0.8 0.0 0.4 0.2 0.2 0.9
Lupus 0.9 1.4 5.1 0.5 1.2 0.5 -0.1 2.3
Neuroticism 1.0 1.5 3.1 0.2 -1.1 0.0 1.7 1.8
Primary Biliary Cirrhosis 0.7 1.0 1.4 1.1 1.0 1.1 1.2 -0.4
Rheumatoid Arthritis 0.6 0.9 2.1 1.4 0.2 0.8 0.8 0.9
Schizophrenia 0.3 0.7 1.2 -0.8 -0.9 -1.0 -0.3 1.1
Triglycerides 1.0 1.6 4.7 -0.2 -1.4 -0.9 2.2 0.7
Type 2 Diabetes (T2D) 0.5 0.6 1.7 0.3 0.9 -0.1 1.3 -0.6
Ulcerative Colitis 0.7 1.1 3.2 0.3 0.9 0.5 -1.0 -1.8
Blood Eosinophil Count 0.4 3.3 7.9 -0.8 2.3 0.3 -1.6 -2.8
Blood Platelet Count 0.5 5.4 12.5 0.6 3.4 1.0 -3.5 1.0
Blood Red Count 0.7 7.4 14.4 2.0 2.8 2.2 2.5 3.8
Blood White Count 0.1 0.8 1.8 1.0 1.3 0.7 -0.1 0.9
Heel T-Score 0.4 3.1 5.7 -1.9 -1.4 -2.4 -1.8 -0.7
BMI 1.1 6.7 25.7 -0.8 -1.1 -1.2 2.1 5.1
Height 0.0 0.9 1.7 0.8 -1.3 -0.7 -0.4 -1.2
Waist Hip Ratio (WHR) 0.1 0.3 0.6 0.8 0.6 0.6 0.2 0.3
Systolic Blood Pressure 0.6 3.1 7.6 2.3 2.8 1.5 -0.4 0.4
Smoking Status 0.5 1.3 4.6 0.6 0.3 0.7 0.9 2.1
Allergy or Eczema 1.1 2.8 7.3 1.3 1.3 1.4 -1.1 -2.7
Cardiovascular Disease 0.4 1.2 3.9 -0.6 0.5 -1.1 0.6 2.0
Hypothyroidism (self reported) 0.4 1.0 2.2 -0.1 1.1 -0.2 1.5 1.1
Respiratory disease 1.4 3.0 12.5 -0.6 -0.3 -1.0 -3.5 -1.0
Type 2 Diabetes (T2D) 1.2 2.2 8.4 0.4 -0.2 -0.3 2.9 1.4
Lung FEV1/FVC ratio 0.5 2.4 8.6 1.1 -1.4 -0.5 2.9 0.3
Lung FVC 1.5 7.8 18.7 -2.3 -2.2 -2.7 -4.3 -1.7
Neuroticism 4.5 11.1 31.7 2.2 0.8 1.2 4.1 5.6
Chronotype (morning person) 0.2 0.4 1.0 -0.5 -0.2 -0.7 -1.0 -0.3
Hair Pigment 0.1 2.7 6.1 -0.5 -2.1 -0.5 -1.6 2.5
Tanning 0.1 1.0 4.7 -0.4 -0.1 -0.4 -0.4 2.2
Hand grip strength (left) 1.8 4.9 9.7 -3.1 -1.6 -2.1 -2.0 -2.0
Number of treatments/medications taken 1.6 2.9 7.4 -1.0 -1.9 -0.8 -1.4 -2.7
Average weekly spirits intake 0.7 0.9 2.2 -1.5 -0.2 -0.7 -1.2 -0.6
Sensitivity / hurt feelings 3.1 5.4 11.9 -2.0 0.0 -1.3 -3.1 -3.5
Frequency of depressed mood in last 2 weeks 2.4 3.4 12.9 -0.8 -0.4 -0.6 -1.7 -3.6
Hearing difficulty/problems: Yes 0.7 1.1 2.6 1.2 0.8 0.7 -1.6 0.5
Relative age of first facial hair 0.8 1.8 7.7 0.3 0.9 0.2 2.8 0.4
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.7 1.9 0.7 1.3 2.2 -1.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.7 1.2 0.9 1.3 0.5 0.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 0.2 0.7 -0.3 0.3 -0.6
Systolic blood pressure, automated reading 0.2 0.6 1.7 -0.9 -1.3 -0.6 0.3 0.3
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 7.5 0.4 0.3 0.7 -0.1 -2.7
Angina 0.5 0.7 1.6 -0.3 -1.3 -1.2 -0.5 0.3
Medication for hormone replacement therapy 0.2 0.3 1.0 0.3 -0.3 0.3 -0.2 -1.0
Vitamin and mineral supplements 0.6 0.8 2.2 0.0 1.2 0.7 1.5 -0.0
Supplements: Zinc 1.3 1.4 5.3 0.1 -0.6 -0.2 -1.2 2.3
Medication: Co-codamol 0.2 0.3 0.6 -0.8 -0.2 -0.4 -0.4 -0.6
Medication: Metformin 1.4 2.0 4.1 0.1 1.2 1.1 -2.0 -1.8
Diabetes (father) 1.0 1.2 2.4 0.8 0.7 1.5 1.6 -0.7
Diabetes (mother) 0.6 0.8 3.6 -0.1 -0.2 -0.2 -1.9 0.2
Severe depression (siblings) 1.2 1.3 3.0 1.7 1.2 1.4 -0.2 0.4
Pack years adult smoking proportion 0.6 1.0 1.9 1.2 0.2 0.4 -1.4 -1.1
Impedance of leg (right) 0.5 2.7 5.5 -2.3 -1.3 -2.1 0.8 -1.1
Leg fat-free mass (left) 0.3 1.5 5.4 0.3 0.3 0.6 -2.3 -1.2
Trunk fat percentage 1.6 6.4 18.4 -0.5 0.4 -0.0 -3.6 -4.3
Hand grip strength (right) 1.3 3.5 6.9 -2.6 -1.4 -2.1 -1.1 -1.8
Townsend deprivation index at recruitment 0.8 1.1 3.5 0.3 0.7 0.2 -1.3 -1.9
Current tobacco smoking 3.1 5.0 10.1 -1.1 -1.4 -1.4 -3.1 -3.2
Average weekly fortified wine intake 0.6 0.7 3.0 0.6 0.4 0.4 1.7 -0.2
Maternal smoking around birth 2.0 2.8 7.5 -0.3 -0.9 -0.8 -2.7 -2.3
Fed-up feelings 2.7 5.0 20.4 -0.7 -0.3 -0.4 -2.0 -4.5
Frequency of unenthusiasm / disinterest in last 2 weeks 4.5 6.0 26.1 0.1 0.8 0.6 -1.7 -5.1
Relative age voice broke 2.0 3.1 6.2 1.3 1.2 1.0 2.5 2.3
Taking other prescription medications 0.3 0.5 1.0 -0.7 -0.4 0.4 -0.9 -1.0
Age when periods started (menarche) 1.2 3.0 6.2 -1.7 -2.4 -2.5 -0.3 -0.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 0.9 0.1 0.5 -0.8 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 4.4 0.6 1.5 1.7 2.1 -0.2
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.9 0.1 0.6 0.3 -1.4 -2.0
Qualifications: CSEs or equivalent 1.3 1.8 2.2 -0.9 -1.5 -1.5 1.4 -1.3
Serious illness, injury or assault to yourself 1.6 2.0 3.6 -0.3 -1.7 -1.3 -1.2 -1.9
High blood pressure 0.4 1.0 2.5 1.0 -0.4 1.0 -0.7 -1.6
Hayfever, allergic rhinitis or eczema 1.8 4.0 6.5 -2.5 -1.6 -2.0 0.9 2.5
Multivitamins +/- minerals 0.3 0.4 1.0 -0.4 -0.6 -0.6 -1.0 -0.2
Stomach or abdominal pain in last month 0.5 0.6 2.3 0.0 -0.6 -0.1 -0.7 -1.5
Supplements: Glucosamine 1.5 2.0 3.6 1.3 1.9 1.9 0.6 0.9
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 6.2 -0.3 0.1 -0.8 2.5 1.2
Medication: Atenolol 0.5 0.6 2.0 0.1 -0.6 -0.4 -0.8 -1.4
Medication: Levothyroxine sodium 1.0 1.7 3.8 -1.2 -1.9 -0.6 -1.6 -0.8
Sitting height 0.1 1.0 1.9 -1.0 -1.4 -0.7 -1.3 0.2
Chronic bronchitis/emphysema (father) 2.2 2.6 5.1 -2.3 -0.7 -1.7 -1.7 -1.2
High blood pressure (mother) 0.8 1.2 2.8 -1.7 -1.0 -0.9 -1.1 0.3
Body mass index (BMI) 1.2 5.4 16.1 0.7 0.9 1.2 -2.8 -4.0
Impedance of leg (left) 0.5 2.7 5.2 -2.3 -1.3 -1.9 1.0 -1.4
Leg predicted mass (left) 0.3 1.5 5.5 0.4 0.4 0.6 -2.3 -1.2
Trunk fat mass 1.5 6.7 18.9 -0.3 0.7 0.4 -3.7 -4.3
Waist circumference 1.2 4.7 12.6 0.1 0.3 0.5 -3.2 -3.5
Number of incorrect matches in round 0.5 0.9 3.8 -0.6 0.4 0.3 -0.2 -1.9
Past tobacco smoking 0.3 0.5 0.9 0.4 0.7 0.6 -0.9 0.7
Alcohol usually taken with meals 2.3 3.8 11.4 1.2 0.3 0.6 2.3 3.4
Nervous feelings 3.4 6.5 10.9 -3.3 -1.6 -2.1 -2.6 -2.7
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 5.8 -0.3 0.1 0.1 -0.6 -2.4
Hearing difficulty/problems with background noise 0.4 0.7 1.4 0.5 1.2 0.7 -0.9 0.6
Hair/balding pattern: Pattern 2 1.4 1.8 3.0 -1.7 -1.7 -1.5 -0.4 -0.8
Had menopause 0.2 0.3 0.6 0.7 0.1 0.8 -0.5 -0.1
Had other major operations 1.0 1.2 3.6 -1.0 -1.9 -1.1 0.2 0.6
Forced vital capacity (FVC) 1.0 4.1 12.1 1.3 1.6 1.6 3.5 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.2 0.3 1.3 1.2 1.5 -0.5
Ever unenthusiastic/disinterested for a whole week 1.8 2.3 5.0 1.6 2.2 1.8 0.4 -0.4
Qualifications: None of the above 1.7 3.8 16.9 -0.9 -0.6 -0.9 0.2 -4.1
Financial difficulties in last 2 years 1.7 2.3 7.3 -0.1 1.5 0.7 1.1 -2.7
Mouth/teeth dental problems 0.7 1.1 2.7 1.6 0.3 0.9 0.0 1.3
Heart attack 2.7 3.4 10.4 -0.7 -0.7 -0.6 -2.3 -3.2
Allergy 1.3 2.8 5.4 1.4 1.4 1.1 -2.3 -1.9
Pain all over the body in last month 2.4 2.5 4.3 -1.8 -2.0 -2.1 -0.7 -0.8
Diabetes (self-reported) 1.6 2.5 6.4 -0.5 0.2 0.0 -2.4 -2.5
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.0 -1.4 -0.6 -0.7 1.2 0.5
Medication: Ramipril 0.7 0.9 1.9 -1.0 -0.5 -0.4 -1.4 -1.0
Medication: Simvastatin 0.5 0.8 1.9 -0.1 -0.8 -0.5 -1.4 -1.0
Fluid intelligence score 1.3 2.6 11.5 1.1 0.4 0.4 -0.2 3.4
Illnesses of siblings 0.9 1.3 4.2 -0.5 -2.0 -0.9 0.9 0.6
Neuroticism score 4.0 8.5 27.5 -2.2 -1.2 -1.5 -2.4 -5.2
Weight 0.9 4.4 12.7 0.2 0.7 1.0 -2.8 -3.6
Impedance of arm (right) 0.4 2.1 3.8 -1.8 -0.6 -1.9 -0.1 1.7
Arm fat percentage (right) 1.5 6.1 15.4 -0.2 0.7 0.2 -3.8 -3.9
Trunk fat-free mass 0.2 1.4 2.3 0.4 1.0 1.3 -1.5 -1.3
Hip circumference 1.0 4.3 11.6 0.0 0.4 0.5 -3.4 -3.1
Time employed in main current job 1.6 1.8 4.3 -2.1 -1.0 -1.6 -0.4 1.1
Alcohol intake versus 10 years previously 0.7 1.1 4.7 -0.1 0.5 0.0 -0.7 -2.2
Father’s age at death 0.2 0.3 1.0 -0.3 -0.3 -0.0 0.3 1.0
Worrier / anxious feelings 3.5 6.7 12.3 -3.5 -1.8 -2.7 -1.1 -3.0
Frequency of tiredness / lethargy in last 2 weeks 5.7 9.3 25.5 -2.7 -1.3 -1.9 -2.9 -5.0
Falls in the last year 0.5 0.6 2.6 0.3 0.2 -0.2 1.6 -0.6
Hair/balding pattern: Pattern 3 0.2 0.4 1.6 0.1 0.3 0.3 -1.2 -0.3
Number of live births 0.6 0.8 1.5 -1.2 -0.5 -1.0 0.1 -1.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.9 6.9 0.9 1.7 1.5 2.6 1.3
Pulse rate 2.0 3.5 9.5 -0.6 -1.0 -1.0 -3.1 -2.3
Happiness 1.7 2.1 5.0 1.4 2.2 1.7 0.0 -0.9
Noisy workplace 0.7 0.9 2.3 -1.2 0.2 -0.4 -1.5 -0.8
Qualifications: A levels/AS levels or equivalent 2.3 5.2 14.2 2.6 -0.1 1.4 1.6 3.8
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 1.9 0.9 1.3 1.4 0.9 1.4
Mouth/teeth dental problems: Dentures 1.0 1.7 6.2 -0.8 -0.6 -0.2 -1.1 -2.5
Asthma 1.4 2.6 9.6 -0.3 -1.3 0.1 3.1 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.5 2.0 3.9 -1.1 -2.0 -2.0 -0.9 0.1
Medication: Cholesterol lowering 1.5 2.3 7.9 -0.4 0.1 0.3 -1.8 -2.8
Depression (self-reported) 1.6 1.9 5.6 0.8 2.4 1.7 -0.3 -0.1
Medication: Lansoprazole 8.3 9.5 16.9 -3.2 -2.9 -3.1 -1.4 -4.1
Prospective memory result 3.2 3.9 5.9 -2.4 -1.6 -1.7 -1.6 -2.4
Lung cancer (father) 1.5 1.8 6.5 -1.0 -0.2 -1.0 -2.5 -0.7
Illnesses of mother 1.8 2.3 5.2 2.3 1.3 1.7 1.1 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 7.1 -0.0 1.3 0.8 2.7 1.7
Pulse wave Arterial Stiffness index 1.0 1.1 3.7 -0.4 0.6 0.7 -1.0 -1.9
Impedance of arm (left) 0.5 2.4 5.5 -1.3 -0.6 -1.9 0.8 2.3
Arm fat mass (right) 1.4 5.8 15.4 0.3 1.0 0.8 -3.5 -3.9
Trunk predicted mass 0.2 1.4 2.0 0.5 1.1 1.4 -1.4 -1.2
Standing height 0.0 0.3 0.7 -0.9 -0.1 -0.1 -0.2 0.8
Length of working week for main job 0.2 0.3 1.0 -0.2 0.1 0.2 -1.0 0.5
Exposure to tobacco smoke at home 0.9 1.0 2.2 0.4 1.5 0.6 0.6 -1.3
Breastfed as a baby 0.5 0.7 1.1 0.1 1.0 0.8 0.9 -0.9
Tense / ‘highly strung’ 0.5 0.8 2.1 -0.4 0.4 0.4 -1.4 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 2.9 -1.0 -1.0 -1.4 -1.7 -1.7
Hair/balding pattern: Pattern 4 0.6 1.4 2.5 1.5 1.1 1.6 -0.3 1.2
Birth weight of first child 1.1 2.0 5.9 0.9 0.9 1.4 2.4 -0.9
Peak expiratory flow (PEF) 0.5 1.2 2.3 1.0 1.1 1.5 1.2 0.0
Pulse wave reflection index 0.9 1.1 2.4 0.1 1.1 1.3 1.6 0.7
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.7 -0.3 0.4 0.3 -0.9 -2.2
Loud music exposure frequency 0.2 0.2 0.3 0.5 0.5 0.1 0.5 -0.5
Qualifications: O levels/GCSEs or equivalent 2.2 3.5 9.9 1.8 0.8 1.7 0.9 3.1
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 3.3 -1.8 0.2 -1.2 -0.2 0.1
Blood clot in the leg (DVT) 0.3 0.4 1.4 0.1 0.3 -0.4 -1.2 -0.7
Medication: Paracetamol 1.6 2.8 11.7 -0.7 -1.0 -0.6 -0.4 -3.4
Headache pain in last month 1.8 3.2 10.9 -2.1 -0.4 -0.3 -0.5 -3.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 2.7 -0.2 -0.2 -0.7 1.5 1.6
Glaucoma (self-reported) 0.5 0.6 1.4 -0.6 0.7 -0.7 1.2 0.3
Gout (self-reported) 0.4 0.5 1.0 -0.6 -1.0 -0.5 -0.5 0.9
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.0 -0.4 -1.6 -0.5 -1.7 -0.4
Medication: Amlodipine 0.9 1.3 3.5 1.1 0.6 1.0 -1.9 -0.5
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.7 0.7 -1.3 0.2 1.0 1.2
Birth weight 0.5 1.1 3.4 0.2 1.9 0.9 1.2 -0.2
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.6 1.2 0.6 0.9 0.5 0.3
High blood pressure (siblings) 0.9 1.3 3.6 0.7 1.9 1.4 -0.3 -0.7
Forced vital capacity (FVC), Best measure 1.0 3.6 14.4 0.3 0.9 0.8 3.8 1.4
Body fat percentage 1.8 7.2 24.1 -0.4 0.3 -0.0 -3.4 -4.9
Leg fat percentage (right) 2.1 7.6 30.7 -0.2 0.7 0.1 -2.6 -5.5
Arm fat-free mass (right) 0.3 1.4 3.4 0.7 0.6 1.2 -1.2 -1.9
Exposure to tobacco smoke outside home 1.0 1.3 6.0 -0.7 -0.2 -0.4 0.1 -2.4
Comparative body size at age 10 1.0 2.7 4.8 1.9 2.2 2.1 0.2 -0.7
Number of full brothers 1.8 2.3 3.5 -1.9 -1.1 -1.5 -1.8 -1.0
Worry too long after embarrassment 0.5 0.8 2.3 -0.5 -0.1 -0.5 -1.1 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.8 -0.2 0.4 -0.0 1.0 -2.0
Wheeze or whistling in the chest in last year 0.3 0.5 1.2 0.7 0.3 1.1 0.7 -0.4
Number of children fathered 0.3 0.3 0.8 -0.6 -0.1 -0.2 -0.9 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 7.5 0.6 0.1 0.5 -1.2 2.7
Age at first live birth 1.3 2.4 8.7 0.3 0.8 0.6 3.0 1.5
Pulse wave peak to peak time 1.1 1.3 4.4 0.3 -0.6 -0.7 1.0 2.1
Health satisfaction 1.1 1.4 2.1 0.7 1.1 1.4 -1.1 -1.4
Shortness of breath walking on level ground 2.8 3.3 6.3 1.1 2.5 2.5 1.4 -1.0
Qualifications: College or University degree 3.4 10.8 40.3 2.3 1.4 1.9 1.7 6.3
Eye problems/disorders: None of the above 1.1 1.3 2.6 1.2 -0.9 1.1 -1.6 0.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 3.9 -0.0 2.0 1.4 -0.7 -0.8
Emphysema/chronic bronchitis 2.3 2.7 9.7 1.4 0.3 0.8 0.9 -3.1
Medication for pain relief, constipation, heartburn 2.6 4.5 7.1 1.4 2.3 1.6 2.7 2.3
Neck or shoulder pain in last month 1.5 2.2 9.9 0.0 0.3 0.4 -0.8 -3.1
Medication: Blood pressure 0.4 0.7 2.1 0.2 0.1 0.5 -1.4 -1.1
Angina (self-reported) 0.8 1.0 2.3 -0.5 -1.5 -1.4 -0.7 0.2
Migraine (self-reported) 0.8 1.0 4.0 -2.0 0.3 -0.5 -0.8 0.0
Medication: Ibuprofen 1.2 1.5 2.9 -1.0 -1.6 -1.7 -0.8 -0.2
Medication: Allopurinol 0.6 0.9 1.8 -1.0 -1.0 -0.8 -1.3 0.1
Medication: Omeprazole 0.7 0.9 1.7 1.3 1.2 1.1 0.3 -0.1
Medication: Seretide 50 evohaler 1.3 1.5 2.5 1.3 0.4 1.1 1.5 -1.6
Mean time to correctly identify matches 1.1 2.1 4.6 2.1 0.5 1.2 2.0 -0.3
Heart disease (mother) 0.3 0.3 0.7 -0.2 0.9 0.2 -0.2 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.4 2.8 6.1 1.1 2.5 1.8 1.7 0.9
Whole body fat mass 1.7 7.3 22.0 -0.3 0.4 0.2 -3.7 -4.7
Leg fat mass (right) 1.8 7.2 26.7 0.0 0.5 0.3 -3.0 -5.2
Arm predicted mass (right) 0.4 2.0 5.1 0.9 0.8 1.4 -1.2 -2.3
Pulse rate, automated reading 0.9 3.0 12.8 -1.0 -0.1 -0.9 -3.6 -0.3
Alcohol intake frequency. 2.4 5.7 20.1 2.2 0.5 1.8 -0.1 -4.5
Comparative height size at age 10 0.0 0.3 0.8 0.0 0.7 0.9 -0.1 0.1
Number of full sisters 2.5 3.1 7.3 1.1 1.3 2.0 0.9 -2.7
Suffer from ‘nerves’ 3.6 5.7 9.6 -3.1 -2.2 -2.8 -1.8 -1.7
Overall health rating 3.1 6.7 31.9 0.0 0.5 0.2 -1.2 -5.6
Chest pain or discomfort 1.3 1.9 4.4 -1.0 -1.3 -1.1 -1.1 -2.1
Had major operations 0.1 0.1 0.4 0.2 0.7 -0.0 -0.2 -0.0
Age at last live birth 0.9 1.3 5.5 -0.6 -0.1 -0.5 2.3 0.6
Family relationship satisfaction 0.1 0.1 0.5 0.3 0.2 0.3 -0.2 -0.7
Leg pain on walking 1.3 1.6 4.9 -1.2 0.0 -0.4 -2.2 -1.3
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 5.8 0.1 -0.2 0.4 1.0 -2.4
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.6 0.7 0.9 1.6 1.6 -0.5
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 6.9 -0.2 -0.3 -0.5 0.2 2.6
Medication: Aspirin 1.9 2.5 7.2 -0.1 -1.0 -0.3 -2.7 -2.1
Supplements: Vitamin C 0.5 0.6 2.6 0.7 -1.6 0.2 -0.1 0.1
Knee pain experienced in last month 2.9 4.5 14.4 -2.0 -0.4 -1.0 -1.8 -3.8
Hypertension (Self-reported) 0.4 1.1 2.0 1.1 -0.2 1.1 -1.0 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.7 -0.4 -0.4 -0.3 1.3 -0.0
Illnesses of father: Heart disease 0.9 1.3 2.4 1.6 1.1 1.4 0.4 -0.9
Illnesses of siblings: Diabetes 0.6 0.8 2.2 -0.6 0.8 -0.0 -1.5 -0.9
Smoking status: Previous 0.3 0.4 1.8 -0.5 -0.2 -0.2 1.3 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 4.9 -1.9 -1.5 -2.2 -0.8 0.3
Whole body fat-free mass 0.2 1.4 3.1 0.4 0.6 1.0 -1.8 -1.5
Leg fat-free mass (right) 0.2 1.3 4.8 0.5 0.4 0.8 -2.2 -0.8
Arm fat percentage (left) 1.2 4.8 12.7 0.1 0.8 0.3 -3.3 -3.6
Average weekly red wine intake 3.5 5.2 6.8 2.6 2.0 2.6 2.2 1.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.4 -0.3 -1.2 -0.5 -0.2 0.4
Mood swings 3.0 5.5 17.0 -1.7 -1.0 -0.8 -2.4 -4.1
Loneliness, isolation 2.2 3.1 12.7 0.3 1.1 0.5 -1.1 -3.6
Long-standing illness, disability or infirmity 1.2 1.8 4.8 -0.8 -1.6 -0.7 -0.9 -2.2
Ever had bowel cancer screening 0.8 0.9 2.4 0.4 1.0 0.8 1.5 -0.6
Diabetes diagnosed by doctor 2.1 3.4 8.1 -0.9 -0.5 -0.4 -2.8 -2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.8 1.0 -0.6 0.4 1.3 -0.4
Friendships satisfaction 0.5 0.6 1.2 1.1 0.3 0.8 -0.8 -0.6
Qualifications: nursing, teaching 3.7 5.8 17.8 2.9 1.0 1.5 -0.0 4.2
Commuting to job workplace: Walk 0.8 0.8 1.5 -1.0 -0.4 -1.2 -1.1 -0.2
Eye problems/disorders: Cataract 1.1 1.2 3.3 0.2 1.4 0.3 1.8 0.9
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 6.2 0.2 1.2 0.9 2.5 0.0
Medication for cholesterol 0.7 1.1 2.0 0.4 1.4 0.6 1.3 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 0.4 -0.1 -0.2 0.5 -0.0
Back pain experienced in last month 1.5 2.2 8.0 -1.3 -0.4 -0.7 -0.8 -2.8
Mineral and other dietary supplements 2.0 2.7 4.6 -1.4 -1.8 -2.1 -1.6 -1.0
Breast cancer (self-reported) 3.9 4.7 8.6 -2.6 -2.9 -2.4 -1.3 -0.9
Asthma (self-reported) 1.4 2.7 10.4 -0.2 -1.2 0.3 3.2 1.3
Osteoporosis (self-reported) 1.7 2.1 5.4 0.9 -1.2 -0.0 1.7 2.3
Osteoarthritis (self-reported) 1.7 2.2 6.3 1.0 1.5 1.1 -0.2 -2.5
Medication: Aspirin 1.7 2.2 6.7 -0.2 -1.1 -0.5 -2.6 -1.7
Medication: Gliclazide 0.8 0.9 3.1 0.6 0.5 0.6 -1.7 -0.6
Illnesses of father: None of the above (group 1) 1.4 1.7 4.5 -1.4 -0.8 -2.1 -0.1 1.2
Smoking status: Current 2.8 4.5 9.1 -1.0 -1.5 -1.4 -2.8 -3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.5 -0.6 1.2 0.2 0.6 0.3
Whole body water mass 0.3 1.5 3.1 0.4 0.7 1.1 -1.8 -1.5
Leg predicted mass (right) 0.2 1.2 4.3 0.6 0.4 0.9 -2.1 -0.7
Arm fat mass (left) 1.2 5.1 13.5 0.1 0.8 0.5 -3.3 -3.7
Number of self-reported non-cancer illnesses 0.3 0.5 1.8 -0.8 -0.4 0.3 -0.1 -1.3
Average weekly champagne plus white wine intake 1.8 2.5 8.6 -0.0 -0.4 -0.1 1.9 2.9
Miserableness 1.5 2.7 7.1 -0.4 -1.0 -0.5 -2.2 -2.7
Guilty feelings 1.5 2.3 8.2 -1.2 0.0 -0.4 -1.3 -2.9
Wears glasses or contact lenses 0.3 0.3 0.9 0.1 0.7 0.4 1.0 -0.2
Ever taken oral contraceptive pill 0.1 0.2 0.3 -0.5 -0.3 -0.5 0.0 -0.4
Hearing aid user 0.4 0.4 0.9 0.6 1.0 0.6 -0.1 0.7
Mother’s age at death 0.5 0.7 1.7 -0.8 -1.3 -0.6 0.1 0.8
Financial situation satisfaction 2.0 2.5 10.4 0.1 1.0 0.6 0.9 -3.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.5 -0.6 0.3 0.5 1.6 -0.7
Commuting to job workplace: Public transport 0.7 0.9 3.8 0.6 -0.1 -0.1 0.4 1.9
Eye problems/disorders: Glaucoma 1.1 1.3 3.3 -0.6 1.7 -0.2 1.8 -0.4
Medication: Blood pressure 0.4 0.7 2.8 -0.0 -0.8 0.0 0.1 -1.7
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.9 0.2 1.2 1.0 -0.7 -1.7
Supplements: Fish oil (including cod liver oil) 1.5 1.9 4.1 1.3 1.3 1.4 2.0 0.6
High cholesterol (Self-reported) 0.5 0.9 4.1 0.3 -0.0 0.2 0.2 -2.0
Medication: Bendroflumethiazide 1.1 1.7 6.0 -0.1 1.1 1.0 0.2 -2.5
Medication: Paracetamol 1.4 2.2 8.5 -0.6 -1.1 -0.8 -0.3 -2.9
Medication: Lisinopril 0.3 0.4 1.1 1.1 0.1 0.8 -0.0 -0.5
Medication: Atorvastatin 1.1 1.4 3.4 1.1 1.8 1.3 -0.1 -0.7
Illnesses of father: High blood pressure 0.4 0.5 1.2 -0.7 -0.7 -0.2 -0.5 1.1
Alcohol drinker status: Never 0.7 0.8 3.0 0.5 0.4 0.4 -0.7 -1.7
Ever smoked 0.4 0.7 1.2 -1.1 -0.7 -1.1 0.6 -0.5
Basal metabolic rate 0.4 2.1 4.9 0.2 0.6 0.9 -2.2 -2.0
Leg fat percentage (left) 2.1 7.7 31.4 -0.1 0.8 0.5 -2.5 -5.6
Arm fat-free mass (left) 0.4 2.2 7.2 0.4 0.8 1.2 -1.4 -2.7
Number of operations (self-reported) 0.4 0.6 1.5 -0.7 -1.2 -1.0 -0.0 0.1
Average weekly beer plus cider intake 1.8 2.6 5.7 -2.0 -1.0 -1.3 -0.9 -2.4
Irritability 0.5 0.8 3.3 0.2 0.5 0.4 -0.6 -1.8
Risk taking 0.6 0.9 3.2 0.4 1.8 0.7 -0.9 -0.1
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.7 1.7 1.5 1.5 0.8 0.5
Fractured/broken bones in last 5 years 0.2 0.3 0.9 -0.1 -0.9 -0.7 0.1 0.4
Age started oral contraceptive pill 2.4 3.0 3.8 1.7 1.9 1.9 1.9 1.1
Diastolic blood pressure, automated reading 0.5 1.6 4.4 -0.9 -2.1 -0.6 -0.7 -1.4
Ever depressed for a whole week 1.1 1.3 3.6 0.6 0.7 0.8 -1.2 -1.9
Unable to work because of sickness or disability 0.6 0.7 2.8 0.1 0.8 0.4 0.0 -1.7
Commuting to job workplace: Cycle 0.9 1.1 2.3 0.3 -1.0 -0.3 1.5 1.4
Myopia 0.7 1.0 3.8 0.0 0.7 0.9 -2.0 -0.3
Vascular/heart problems diagnosed by doctor 0.8 2.1 6.6 -0.3 0.9 -0.4 1.6 2.6
Cholesterol lowering medication 0.1 0.2 0.4 0.1 -0.4 -0.5 -0.6 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.8 0.2 0.8 0.5 -0.0 -0.9
Pain experienced in last month 2.1 3.6 13.4 1.5 -0.5 -0.4 1.3 3.7
Supplements: Calcium 0.1 0.1 0.6 0.1 0.4 0.7 0.2 0.1
Basal cell carcinoma (self-reported) 0.2 0.3 0.5 0.1 0.6 0.6 0.7 -0.5
Heart attack/myocardial infarction (self-reported) 2.4 3.1 10.8 -0.3 -0.3 -0.3 -2.1 -3.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 -0.1 0.2 -0.6 -0.9 -0.4
Heart disease (siblings) 1.3 1.6 2.9 1.7 1.6 1.4 -0.5 -0.8
Alcohol drinker status: Previous 2.5 2.8 4.7 2.2 1.3 1.9 1.0 -1.8
Pack years of smoking 0.7 1.1 2.4 1.5 0.4 0.8 -1.0 -1.0
Impedance of whole body 0.4 2.2 4.9 -1.9 -1.1 -2.2 0.8 0.8
Leg fat mass (left) 1.8 7.1 26.5 0.2 0.7 0.6 -2.9 -5.1
Arm predicted mass (left) 0.5 2.8 7.7 0.7 0.8 1.4 -1.8 -2.8