Hub : Genes

GBE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1436	0.0566	0.00027	0.132	NA	0.073	NA	0.022	1.8e-05	NA	0.00140	NA	5.2e-02
2	NTR	Blood	0.0210	0.0102	0.00086	0.018	0.010	0.010	0.010	0.015	1.1e-06	0.0003	0.00025	0.00018	8.8e-06
3	YFS	Blood	0.0133	0.0071	0.00420	0.000	0.004	0.003	0.004	0.002	2.1e-01	0.0120	0.02500	0.01300	5.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	1.0	0.1	-0.1	-1.0
Bipolar Disorder or Schizophrenia	2.2	5.3	8.6	2.0	-1.8	-2.9
Depressed Affect (Nagel 2018)	3.4	7.1	8.8	-2.1	3.0	2.8
Depression (Nagel 2018)	2.9	4.3	7.4	-1.6	1.8	2.7
Intelligence (Savage-Jansen 2018)	2.3	7.1	9.8	-2.7	3.1	2.1
Neuroticism (Nagel 2018)	4.4	10.2	12.5	-2.7	3.3	3.5
Schizophrenia (2018)	3.2	6.7	8.8	2.5	-2.3	-3.0
Schizophrenia vs Biploar Disorder	2.8	3.7	5.9	1.5	-2.4	-1.7
Worry (Nagel 2018)	0.3	0.6	0.9	0.1	1.0	0.9
Alzheimer’s Disease (in mother)	3.0	3.5	4.1	-2.0	2.0	1.6
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.5	-0.8	-0.5
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.3	0.3	0.3
Crohns Disease (2017)	0.2	0.5	1.3	-0.1	-1.1	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.5	0.7	-0.7	-0.6
Ulcerative Colitis (UC)	1.0	1.8	3.2	1.4	-0.6	-1.8
Major Depression (MDD)	0.7	0.8	2.5	0.3	0.1	1.6
Reaction Time	5.1	9.7	13.2	3.4	-2.2	-3.6
Verbal and Numeric Reasoning (VNR)	3.7	8.8	13.4	-2.9	3.7	2.2
Breast Cancer	0.1	0.2	0.4	-0.6	-0.4	-0.1
Ovarian Cancer	0.5	0.7	1.5	-1.2	0.6	0.4
Prostate Cancer	0.1	0.2	0.3	0.5	-0.3	0.6
Age at First Birth	0.4	0.6	1.7	0.3	-1.3	0.3
Bipolar Disorder (2011)	3.4	3.2	3.6	1.9	-1.6	-1.9
Body Mass Index (BMI) (2010)	7.6	10.4	13.2	3.6	-2.9	-3.1
Coronary Artery Disease (CAD)	2.1	2.5	3.6	1.9	-0.8	-1.8
Crohns Disease (2012)	0.4	0.7	1.0	-0.9	-0.4	1.0
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.0	-0.6
Fasting Glucose	0.5	0.6	0.9	0.9	-0.5	-0.9
HbA1C	1.2	1.3	2.1	1.5	-0.7	-1.2
HDL Cholesterol	2.7	4.5	6.4	-2.1	2.5	1.6
LDL Cholesterol	1.7	2.6	3.8	2.0	-1.3	-1.5
Lupus	0.2	0.3	0.5	0.7	0.1	-0.5
Neuroticism (2016)	2.7	4.0	6.3	-1.8	1.6	2.5
Primary Biliary Cirrhosis	0.2	0.3	0.4	0.2	-0.6	-0.7
Rheumatoid Arthritis	1.1	1.5	2.2	-0.7	1.3	1.5
Schizophrenia (2014)	2.0	4.4	6.8	1.7	-1.9	-2.6
Triglycerides	1.9	3.0	3.2	1.8	-1.8	-1.7
Type 2 Diabetes (T2D) (2012)	3.4	3.9	6.2	1.4	-2.5	-1.9
Ulcerative Colitis	1.2	1.8	2.6	1.6	-0.4	-1.6
Blood Eosinophil Count	1.4	11.2	13.5	3.2	-3.1	-3.7
Blood Platelet Count	0.0	0.4	1.1	0.0	0.4	1.1
Blood Red Count	0.1	0.8	2.1	0.5	-0.4	-1.4
Blood White Count	0.8	5.6	8.5	2.5	-1.5	-2.9
Heel T-Score	0.0	0.2	0.4	-0.2	-0.3	0.6
BMI	3.3	19.2	30.1	3.5	-3.9	-5.5
Height	0.2	3.6	6.6	1.8	-2.6	-1.0
Waist Hip Ratio (WHR)	1.2	5.2	12.5	1.7	-0.5	-3.5
Systolic Blood Pressure	0.0	0.2	0.4	0.0	0.5	0.6
Smoking Status	0.4	1.0	2.4	-0.7	1.5	0.2
Allergy or Eczema	0.1	0.3	0.7	0.1	-0.3	-0.9
Cardiovascular Disease	1.4	4.8	6.8	2.1	-1.7	-2.6
Hypothyroidism (self reported)	0.5	1.1	2.6	1.6	-0.7	-0.6
Respiratory disease	0.1	0.3	0.6	0.3	0.6	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	0.3	0.5	-1.3
Lung FEV1/FVC ratio	0.5	2.5	3.6	0.8	-1.9	-1.9
Lung FVC	0.5	2.5	5.0	-1.1	1.1	2.2
Neuroticism	6.9	16.7	21.1	-3.7	4.0	4.6
Chronotype (morning person)	6.4	14.7	17.7	-4.2	4.1	3.1
Hair Pigment	0.0	0.3	0.5	-0.3	-0.7	0.5
Tanning	0.3	3.9	5.8	-2.4	2.4	0.5
Hand grip strength (left)	6.1	16.0	22.4	-4.7	3.2	4.0
Number of treatments/medications taken	0.2	0.3	0.7	-0.2	0.4	-0.9
Average weekly spirits intake	0.2	0.3	0.6	-0.8	0.0	0.4
Sensitivity / hurt feelings	5.2	8.9	12.4	-3.1	2.2	3.5
Frequency of depressed mood in last 2 weeks	3.8	5.3	10.8	-1.8	1.4	3.3
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.4	-0.2	0.5
Relative age of first facial hair	0.6	1.3	2.7	-0.8	0.7	1.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.6	-0.9	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.3	0.3	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	0.4	-0.2	1.0
Systolic blood pressure, automated reading	0.3	0.9	2.3	-0.7	1.5	0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	-0.2	-0.2
Angina	0.3	0.4	0.8	-0.9	0.5	0.6
Medication for hormone replacement therapy	0.6	0.7	1.1	-0.8	0.4	1.1
Vitamin and mineral supplements	3.9	5.3	9.4	2.4	-3.1	-0.7
Supplements: Zinc	2.2	2.4	5.0	1.4	-0.4	-2.2
Medication: Co-codamol	3.1	3.5	5.3	-1.8	2.3	1.4
Medication: Metformin	0.0	0.0	0.0	-0.2	0.1	-0.1
Diabetes (father)	1.3	1.6	2.1	1.2	-1.1	-1.4
Diabetes (mother)	1.8	2.3	2.9	1.3	-1.7	-1.5
Severe depression (siblings)	0.5	0.6	1.2	-0.2	1.1	0.7
Pack years adult smoking proportion	0.8	1.2	2.9	-0.6	1.7	0.6
Impedance of leg (right)	0.0	0.1	0.2	0.4	-0.0	-0.2
Leg fat-free mass (left)	0.3	1.8	2.3	0.9	-1.5	-1.5
Trunk fat percentage	5.6	22.4	28.6	4.6	-4.1	-5.3
Hand grip strength (right)	3.9	10.5	13.2	-3.6	2.5	3.5
Townsend deprivation index at recruitment	0.4	0.6	1.5	0.3	1.2	0.6
Current tobacco smoking	0.6	0.9	1.9	-0.1	1.4	-0.9
Average weekly fortified wine intake	1.3	1.5	2.7	1.2	-0.6	-1.7
Maternal smoking around birth	1.1	1.5	3.0	1.7	0.1	-1.3
Fed-up feelings	4.7	8.6	14.0	-2.0	2.8	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.4	6.1	-1.7	1.2	2.5
Relative age voice broke	0.9	1.3	2.8	-0.7	0.9	1.7
Taking other prescription medications	0.0	0.1	0.1	-0.3	-0.3	-0.2
Age when periods started (menarche)	0.5	1.2	1.7	0.6	-1.3	-1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.8	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.6	0.7	-0.7	-0.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.4	3.7	-0.8	1.9	0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.3	0.4	-1.1	0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.4	1.3	-0.0
High blood pressure	1.6	4.5	7.6	2.0	-1.4	-2.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	0.5	-0.6	-0.7
Multivitamins +/- minerals	1.0	1.3	3.4	-0.6	1.8	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.3	-0.3	0.2	0.5
Supplements: Glucosamine	5.0	6.5	9.9	-2.3	3.2	2.1
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.4	-1.0	1.6	1.5
Medication: Atenolol	0.0	0.1	0.1	-0.2	-0.4	0.0
Medication: Levothyroxine sodium	1.0	1.7	3.9	2.0	-0.7	-0.9
Sitting height	0.0	0.3	0.6	-0.4	-0.7	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.2	0.5	-0.4	-0.4
High blood pressure (mother)	2.6	3.7	4.5	2.1	-1.9	-1.7
Body mass index (BMI)	2.5	10.7	15.9	2.9	-2.8	-4.0
Impedance of leg (left)	0.0	0.2	0.4	0.6	-0.5	0.0
Leg predicted mass (left)	0.4	1.9	2.5	1.0	-1.6	-1.6
Trunk fat mass	4.1	17.4	23.9	3.9	-3.7	-4.9
Waist circumference	3.5	12.7	17.7	3.1	-3.3	-4.2
Number of incorrect matches in round	0.4	0.7	1.2	1.1	-0.6	-0.9
Past tobacco smoking	1.1	2.0	2.0	1.4	-1.4	-1.4
Alcohol usually taken with meals	1.8	2.8	4.0	-2.0	1.5	1.5
Nervous feelings	2.4	4.5	6.1	-1.9	1.9	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.5	-0.9	0.5	1.9
Hearing difficulty/problems with background noise	0.7	1.2	2.7	-0.6	0.7	1.6
Hair/balding pattern: Pattern 2	0.8	1.0	3.0	0.3	-1.7	0.0
Had menopause	1.3	1.7	2.6	-1.2	1.6	0.9
Had other major operations	0.2	0.2	0.6	-0.2	-0.8	-0.2
Forced vital capacity (FVC)	1.5	5.9	8.9	-2.9	0.8	3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.6	0.9	-1.2	-1.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	2.4	-1.4	1.3	1.5
Qualifications: None of the above	0.9	1.9	2.4	1.5	-1.2	-1.3
Financial difficulties in last 2 years	0.0	0.1	0.1	0.2	0.2	0.3
Mouth/teeth dental problems	3.8	5.9	8.9	-2.4	1.7	3.0
Heart attack	0.5	0.7	1.5	0.1	0.7	-1.2
Allergy	0.2	0.4	0.9	-0.9	0.3	0.4
Pain all over the body in last month	0.3	0.3	0.6	-0.5	-0.0	-0.8
Diabetes (self-reported)	0.3	0.5	0.9	-0.3	0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.3	1.1	-0.8	-0.7
Medication: Ramipril	0.7	0.9	1.4	0.9	0.6	-1.2
Medication: Simvastatin	0.8	1.1	2.5	0.7	0.6	-1.6
Fluid intelligence score	1.8	3.6	5.5	-2.3	2.2	0.8
Illnesses of siblings	0.2	0.3	1.0	0.1	-0.1	1.0
Neuroticism score	6.6	13.7	17.8	-3.3	3.5	4.2
Weight	1.8	8.8	11.2	2.4	-3.0	-3.3
Impedance of arm (right)	0.2	1.0	2.0	1.4	-0.9	0.1
Arm fat percentage (right)	4.3	17.0	22.9	4.0	-3.5	-4.8
Trunk fat-free mass	0.0	0.1	0.4	-0.7	0.1	0.0
Hip circumference	3.2	13.7	15.3	3.3	-3.9	-3.9
Time employed in main current job	0.9	1.1	1.9	-1.4	0.5	1.0
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.2	0.8	-0.4
Father’s age at death	1.6	2.1	4.5	-2.1	0.4	1.3
Worrier / anxious feelings	0.3	0.6	1.2	-0.1	0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	4.1	-1.2	1.9	2.0
Falls in the last year	1.0	1.4	2.7	-0.9	1.6	0.8
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.0	-0.1	0.0
Number of live births	1.4	2.0	2.8	1.6	-1.7	-0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.7	-2.1	0.1	2.4
Pulse rate	1.3	2.1	3.3	1.1	-1.4	-1.8
Happiness	3.4	4.1	5.6	-1.8	1.8	2.4
Noisy workplace	0.5	0.6	1.1	0.8	-1.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.1	-1.2	0.3	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.7	1.1	-0.5	-1.3
Mouth/teeth dental problems: Dentures	1.2	2.0	4.2	1.3	-0.4	-2.1
Asthma	0.2	0.3	0.8	0.0	0.9	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.4	-1.0	1.6	0.7
Medication: Cholesterol lowering	0.0	0.1	0.1	-0.0	0.2	-0.4
Depression (self-reported)	2.4	2.9	6.4	-1.1	1.0	2.5
Medication: Lansoprazole	2.8	3.1	4.5	1.6	-1.5	-2.1
Prospective memory result	0.8	1.0	2.4	0.7	-0.2	-1.5
Lung cancer (father)	3.0	3.5	6.5	2.5	-1.9	-0.8
Illnesses of mother	0.6	0.7	1.0	-0.8	1.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	1.8	-1.4	-0.2	1.1
Pulse wave Arterial Stiffness index	1.2	1.4	2.2	-1.4	1.5	0.2
Impedance of arm (left)	0.4	1.6	2.4	1.5	-1.6	-0.5
Arm fat mass (right)	3.4	14.2	18.8	3.6	-3.3	-4.3
Trunk predicted mass	0.0	0.1	0.3	-0.6	0.0	0.0
Standing height	0.0	0.5	0.7	-0.5	-0.7	0.8
Length of working week for main job	0.6	0.7	1.2	1.1	-0.4	-0.9
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.1	-0.0	0.3
Breastfed as a baby	4.4	5.4	7.8	-2.8	2.4	1.6
Tense / ‘highly strung’	0.2	0.4	1.0	1.0	-0.4	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.7	-0.8	0.3	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-0.3	0.7	1.0
Birth weight of first child	1.3	2.3	3.6	0.3	-1.8	-1.9
Peak expiratory flow (PEF)	1.4	3.3	6.3	-1.9	-0.0	2.5
Pulse wave reflection index	2.1	2.6	5.1	-1.4	2.2	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	1.0	0.3	-0.3
Loud music exposure frequency	0.1	0.1	0.1	0.4	0.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	-0.4	-0.9	1.2
Mouth/teeth dental problems: Bleeding gums	4.9	6.3	8.6	2.9	-2.4	-2.1
Blood clot in the leg (DVT)	1.8	2.4	4.5	2.1	-1.1	-1.2
Medication: Paracetamol	1.4	2.3	3.5	-1.1	1.9	1.5
Headache pain in last month	3.2	5.4	7.1	-1.9	2.3	2.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	-0.1	-0.4	0.9
Glaucoma (self-reported)	0.4	0.5	1.5	0.1	-1.2	-0.2
Gout (self-reported)	0.1	0.2	0.3	-0.4	0.5	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.4	1.2	-0.2	-0.2
Medication: Amlodipine	1.9	2.7	4.0	1.5	-2.0	-1.4
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.1	-0.0	-0.1
Birth weight	0.2	0.5	1.3	0.4	-1.1	-0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.3	-0.2	1.1	1.1
High blood pressure (siblings)	0.2	0.3	0.4	-0.6	0.2	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	2.7	-1.6	0.1	1.6
Body fat percentage	5.1	20.1	27.7	4.2	-3.9	-5.3
Leg fat percentage (right)	4.4	16.0	23.3	3.7	-3.3	-4.8
Arm fat-free mass (right)	0.1	0.6	1.0	0.1	-1.0	-0.9
Exposure to tobacco smoke outside home	0.7	1.0	2.2	0.4	1.5	-0.7
Comparative body size at age 10	0.7	1.8	2.9	-1.7	1.3	1.0
Number of full brothers	0.6	0.8	1.1	-0.7	0.9	1.1
Worry too long after embarrassment	2.3	3.9	5.8	-2.4	1.1	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.1	1.1	-0.8	-0.7
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.4	-0.4	-0.1
Number of children fathered	0.5	0.6	0.9	0.5	-0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.0	-1.4	0.6	1.2
Age at first live birth	0.3	0.6	0.9	-0.9	-0.1	1.0
Pulse wave peak to peak time	1.1	1.3	2.4	1.2	-1.6	-0.0
Health satisfaction	0.1	0.2	0.4	0.2	0.7	-0.3
Shortness of breath walking on level ground	1.2	1.4	1.9	1.4	-0.8	-1.2
Qualifications: College or University degree	0.6	1.9	3.0	-1.3	0.9	1.7
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.2	0.4	-0.4
Mouth/teeth dental problems: Loose teeth	3.4	4.1	5.9	2.4	-1.5	-2.0
Emphysema/chronic bronchitis	0.6	0.7	2.0	-0.3	-0.0	1.4
Medication for pain relief, constipation, heartburn	0.4	0.8	1.5	0.8	-1.2	-0.2
Neck or shoulder pain in last month	0.5	0.6	0.8	-0.9	0.7	0.8
Medication: Blood pressure	0.3	0.5	0.8	0.0	0.9	-0.9
Angina (self-reported)	0.5	0.7	1.2	-1.1	0.8	0.6
Migraine (self-reported)	0.8	1.0	1.7	-0.7	1.3	0.9
Medication: Ibuprofen	0.2	0.3	0.5	-0.5	0.7	0.1
Medication: Allopurinol	0.2	0.2	0.6	0.0	0.3	-0.8
Medication: Omeprazole	0.3	0.3	0.8	0.2	0.4	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.0	0.7	-1.0	0.1
Mean time to correctly identify matches	3.4	6.5	10.8	2.8	-1.0	-3.3
Heart disease (mother)	0.5	0.6	0.8	-0.9	-0.9	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.5	5.3	12.2	-1.4	1.4	3.5
Whole body fat mass	3.6	15.1	21.2	3.6	-3.4	-4.6
Leg fat mass (right)	3.4	13.1	19.3	3.2	-3.1	-4.4
Arm predicted mass (right)	0.1	0.6	0.9	0.1	-1.0	-0.9
Pulse rate, automated reading	0.2	0.7	1.0	-1.0	0.9	-0.4
Alcohol intake frequency.	0.1	0.1	0.4	-0.0	-0.1	0.7
Comparative height size at age 10	0.3	1.4	2.9	-0.8	0.8	1.7
Number of full sisters	0.9	1.1	2.9	-1.7	0.1	0.7
Suffer from ‘nerves’	1.5	2.3	4.3	-1.2	1.1	2.1
Overall health rating	0.7	1.5	2.5	-0.0	1.6	-1.4
Chest pain or discomfort	0.3	0.4	0.8	-0.9	0.4	0.5
Had major operations	1.3	1.5	1.7	-1.3	1.3	1.0
Age at last live birth	0.4	0.6	1.2	-0.7	-0.5	1.1
Family relationship satisfaction	2.7	3.3	4.7	-1.3	1.9	2.2
Leg pain on walking	0.5	0.6	1.2	-0.6	1.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.5	0.0	1.9	-0.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	0.5	-1.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	-0.1	-1.1	-0.9
Medication: Aspirin	0.3	0.4	0.9	-0.3	-0.3	-1.0
Supplements: Vitamin C	1.6	1.9	4.6	-1.1	2.1	0.3
Knee pain experienced in last month	0.9	1.4	3.1	-0.9	1.8	0.4
Hypertension (Self-reported)	1.5	4.1	7.0	2.0	-1.1	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.9	1.1	0.2	-1.4
Illnesses of father: Heart disease	0.4	0.6	1.4	0.5	0.2	-1.2
Illnesses of siblings: Diabetes	0.1	0.2	0.2	0.5	0.5	-0.2
Smoking status: Previous	0.9	1.4	2.0	-1.0	1.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.2	-0.2	-0.8
Whole body fat-free mass	0.0	0.2	0.5	-0.0	-0.7	-0.5
Leg fat-free mass (right)	0.3	1.5	2.7	0.8	-1.6	-1.1
Arm fat percentage (left)	4.6	18.2	25.0	3.9	-3.8	-5.0
Average weekly red wine intake	0.2	0.3	0.8	-0.9	0.2	-0.0
Handedness (chirality/laterality): Left-handed	4.4	5.3	5.8	-2.4	2.0	2.4
Mood swings	0.1	0.2	0.4	0.5	0.6	0.3
Loneliness, isolation	11.0	15.3	20.4	-4.5	3.3	3.8
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.3	0.7	-0.7
Ever had bowel cancer screening	1.4	1.6	3.0	1.7	-0.9	-1.1
Diabetes diagnosed by doctor	0.2	0.3	0.4	-0.3	0.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	-0.5	0.6	0.5
Friendships satisfaction	0.0	0.0	0.1	-0.2	0.3	0.1
Qualifications: nursing, teaching	0.3	0.5	1.2	0.4	-1.1	-0.3
Commuting to job workplace: Walk	5.0	5.4	6.4	-2.2	2.3	2.5
Eye problems/disorders: Cataract	1.6	1.9	2.1	-1.5	1.3	1.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.3	1.4	-1.1	-1.5
Medication for cholesterol	2.3	3.5	4.8	-2.2	1.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.5	6.5	8.5	-2.9	2.8	1.8
Back pain experienced in last month	0.3	0.5	0.8	-0.9	0.3	0.7
Mineral and other dietary supplements	6.5	8.8	12.7	3.4	-3.6	-1.4
Breast cancer (self-reported)	0.4	0.4	0.6	-0.3	0.8	0.8
Asthma (self-reported)	0.2	0.5	1.3	-0.3	1.1	-0.2
Osteoporosis (self-reported)	2.9	3.6	5.5	-1.5	1.8	2.3
Osteoarthritis (self-reported)	0.8	1.1	1.4	-1.0	0.9	-1.2
Medication: Aspirin	0.4	0.6	1.1	-0.1	-0.8	-1.0
Medication: Gliclazide	2.4	2.7	4.5	-2.1	1.4	1.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.3	-0.7	0.7
Smoking status: Current	0.5	0.8	1.7	-0.2	1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.8	-0.3	-0.9	0.2
Whole body water mass	0.0	0.2	0.3	-0.1	-0.6	-0.4
Leg predicted mass (right)	0.3	1.4	2.7	0.8	-1.6	-1.0
Arm fat mass (left)	3.7	15.2	20.8	3.6	-3.5	-4.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.2	0.6	-0.4
Average weekly champagne plus white wine intake	0.3	0.5	0.7	-0.7	0.4	0.9
Miserableness	3.8	6.6	8.7	-2.4	2.3	3.0
Guilty feelings	10.7	16.1	26.6	-3.9	2.5	5.2
Wears glasses or contact lenses	1.9	2.2	3.8	-1.4	2.0	0.9
Ever taken oral contraceptive pill	1.2	1.4	2.0	-1.2	0.9	1.4
Hearing aid user	0.1	0.1	0.2	0.4	0.2	0.4
Mother’s age at death	0.9	1.1	1.3	1.2	-1.1	-0.9
Financial situation satisfaction	4.0	4.9	6.1	-1.8	2.5	2.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.1	-0.6	1.4	0.8
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.1	0.8	0.5
Eye problems/disorders: Glaucoma	0.9	1.1	1.7	0.6	-1.3	-1.1
Medication: Blood pressure	5.2	9.8	11.4	3.4	-2.7	-3.3
Pain type(s) experienced in last month: Hip pain	1.5	1.8	2.2	-1.3	1.3	1.5
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.5	-1.6	1.9	0.2
High cholesterol (Self-reported)	0.6	1.1	2.3	0.7	-0.7	-1.5
Medication: Bendroflumethiazide	3.4	5.2	6.2	2.5	-2.3	-2.0
Medication: Paracetamol	0.3	0.5	0.9	-0.7	1.0	0.4
Medication: Lisinopril	1.5	2.0	2.9	1.5	-1.7	-1.0
Medication: Atorvastatin	3.3	4.1	5.0	2.2	-2.1	-1.7
Illnesses of father: High blood pressure	0.3	0.4	0.9	0.5	-0.3	-0.9
Alcohol drinker status: Never	3.3	4.0	7.6	2.8	-1.6	-1.3
Ever smoked	1.3	2.2	2.8	-1.6	1.7	1.1
Basal metabolic rate	0.2	1.3	1.8	0.7	-1.3	-1.3
Leg fat percentage (left)	4.8	17.6	23.7	4.0	-3.6	-4.9
Arm fat-free mass (left)	0.1	0.7	1.0	0.4	-1.0	-1.0
Number of operations (self-reported)	0.1	0.2	0.3	-0.5	0.3	0.4
Average weekly beer plus cider intake	1.4	2.1	3.0	1.5	-1.0	-1.7
Irritability	0.7	1.3	2.1	-0.7	1.5	1.1
Risk taking	0.1	0.1	0.3	0.2	0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	-0.2	1.0	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.3	-1.1	-0.4
Age started oral contraceptive pill	0.1	0.1	0.2	-0.3	0.1	0.4
Diastolic blood pressure, automated reading	0.1	0.4	1.1	-0.0	0.1	-1.0
Ever depressed for a whole week	0.2	0.2	0.6	-0.2	0.8	0.2
Unable to work because of sickness or disability	0.1	0.2	0.2	0.5	0.3	0.4
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.2	-0.6	1.0
Myopia	0.8	1.2	2.6	0.2	1.0	1.6
Vascular/heart problems diagnosed by doctor	1.5	4.1	6.8	-1.9	1.4	2.6
Cholesterol lowering medication	1.2	1.8	3.5	1.2	-0.7	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.5	-0.1	0.7	-0.6
Pain experienced in last month	1.8	3.0	3.8	2.0	-1.2	-1.9
Supplements: Calcium	1.1	1.2	1.6	-1.3	1.1	1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.1	0.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.0	-0.2	1.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	6.5	2.5	-1.4	-1.5
Heart disease (siblings)	0.2	0.2	0.6	-0.1	0.3	-0.8
Alcohol drinker status: Previous	0.2	0.2	0.4	0.3	-0.6	-0.4
Pack years of smoking	1.2	1.8	3.6	-1.0	1.9	0.8
Impedance of whole body	0.2	1.2	1.8	1.3	-1.3	-0.4
Leg fat mass (left)	3.8	15.0	20.3	3.5	-3.5	-4.5
Arm predicted mass (left)	0.2	0.9	1.4	0.6	-1.0	-1.2