Hub : Genes

GPC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.1020 0.0410 0.00440 -0.003 NA 0.014 NA 0.003 9.9e-01 NA 0.02200 NA 0.17000
2 GTEx Testis 0.1920 0.0760 0.00580 0.140 NA 0.037 NA 0.077 9.3e-07 NA 0.00910 NA 0.00026
3 TCGA Brain Lower Grade Glioma 0.0675 0.0365 0.00160 -0.002 0.027 0.028 NA 0.012 6.0e-01 0.00043 0.00033 NA 0.01400
4 TCGA Prostate Adenocarcinoma 0.0853 0.0367 0.00018 0.029 0.030 0.013 NA 0.009 4.9e-04 0.00040 0.01600 NA 0.03400

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.8 1.3 2.1 1.3 1.4 -1.1 -0.3
Bipolar Disorder or Schizophrenia 1.5 3.5 5.1 1.7 2.0 -2.3 -1.5
Depressed Affect (Nagel 2018) 0.2 0.4 1.2 -0.1 -0.4 -0.5 1.1
Depression (Nagel 2018) 0.1 0.1 0.2 0.1 0.4 -0.3 -0.3
Intelligence (Savage-Jansen 2018) 1.8 5.4 17.2 0.3 -4.1 2.1 0.0
Neuroticism (Nagel 2018) 0.1 0.1 0.3 -0.2 -0.5 0.3 0.4
Schizophrenia (2018) 1.6 3.2 4.3 2.1 1.4 -2.0 -1.6
Schizophrenia vs Biploar Disorder 1.3 1.7 3.6 1.9 1.3 -1.1 -0.5
Worry (Nagel 2018) 0.1 0.2 0.5 -0.6 -0.7 0.0 -0.2
Alzheimer’s Disease (in mother) 2.4 2.9 10.6 0.1 -0.0 -0.9 3.2
Alzheimer’s Disease (in father) 0.3 0.3 0.5 0.2 -0.6 -0.5 0.7
Alzheimer’s Disease (including proxy) 1.0 1.5 4.4 0.2 0.6 -1.1 2.1
Crohns Disease (2017) 0.6 1.4 3.3 1.4 1.8 0.4 -0.5
Irritable Bowel Disease (IBD) 2.3 5.5 10.4 2.4 2.3 -0.6 -3.2
Ulcerative Colitis (UC) 4.1 7.7 19.6 2.5 1.8 -1.2 -4.4
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.6 1.2 3.2 -1.8 0.6 -0.7 0.8
Verbal and Numeric Reasoning (VNR) 2.7 6.5 21.7 -0.8 -4.7 1.9 -0.4
Breast Cancer 1.3 3.1 8.6 1.2 2.9 -1.2 0.9
Ovarian Cancer 0.4 0.5 1.6 0.5 -0.5 0.1 -1.3
Prostate Cancer 0.4 0.5 1.3 -0.7 -0.3 0.4 1.1
Age at First Birth 1.9 2.8 4.6 -0.5 1.7 -2.1 -1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 1.9 3.7 -0.7 -1.9 1.7 -0.7
Coronary Artery Disease (CAD) 0.3 0.4 0.7 -0.5 0.8 -0.6 0.5
Crohns Disease (2012) 0.7 1.1 2.6 -0.3 1.3 0.1 -1.6
Mean Putamen Volume 0.7 0.8 1.2 -1.1 -1.1 0.6 0.5
Fasting Glucose 0.6 0.7 2.9 1.7 -0.2 0.0 0.2
HbA1C 0.6 0.7 1.2 -0.7 -0.8 0.6 -1.1
HDL Cholesterol 0.1 0.1 0.2 0.4 -0.2 0.4 0.4
LDL Cholesterol 0.4 0.7 1.7 0.9 -0.3 -1.3 0.5
Lupus 0.8 1.2 2.7 -0.0 -1.4 1.6 0.1
Neuroticism (2016) 0.5 0.7 1.8 -1.3 0.1 -1.0 -0.3
Primary Biliary Cirrhosis 0.6 0.9 2.4 -1.5 -0.8 -0.2 -0.8
Rheumatoid Arthritis 1.5 2.0 3.6 -0.7 -1.9 -1.1 1.6
Schizophrenia (2014) 1.2 2.5 3.9 1.1 2.0 -1.8 -1.3
Triglycerides 0.5 0.9 1.6 -1.2 -1.2 0.6 0.5
Type 2 Diabetes (T2D) (2012) 0.9 1.0 3.0 -1.0 -1.7 0.5 -0.1
Ulcerative Colitis 3.3 4.9 13.9 -0.1 2.1 -1.0 -3.7
Blood Eosinophil Count 0.5 3.5 7.0 -1.6 -2.6 -0.4 2.1
Blood Platelet Count 1.6 18.9 34.9 -1.1 -4.6 5.9 -4.3
Blood Red Count 0.1 0.9 2.4 0.8 0.4 -1.6 -0.6
Blood White Count 0.1 0.6 0.9 1.0 -0.4 -1.0 0.6
Heel T-Score 0.7 5.5 9.4 3.1 2.3 -2.7 -0.1
BMI 2.3 13.5 31.8 -1.9 -5.6 4.1 1.3
Height 0.1 2.0 4.5 -2.1 1.6 0.7 -0.7
Waist Hip Ratio (WHR) 0.2 0.9 1.3 -1.1 -0.8 -1.1 -0.7
Systolic Blood Pressure 0.3 1.6 4.6 -0.8 -1.1 -0.2 -2.1
Smoking Status 0.3 0.7 1.2 -1.0 -0.3 -1.1 -0.8
Allergy or Eczema 0.7 1.9 5.7 -0.8 -0.8 0.8 2.4
Cardiovascular Disease 0.1 0.5 1.6 -0.5 -1.2 0.2 -0.2
Hypothyroidism (self reported) 0.3 0.7 1.2 1.0 -0.5 -0.4 1.1
Respiratory disease 0.7 1.6 3.8 -1.5 -1.9 0.7 0.4
Type 2 Diabetes (T2D) (2018) 1.1 2.1 2.9 0.7 -1.7 1.5 -1.7
Lung FEV1/FVC ratio 0.6 3.2 7.6 -0.8 -2.8 1.1 -1.9
Lung FVC 0.4 2.3 5.2 -0.3 1.9 -0.3 2.3
Neuroticism 0.2 0.4 1.3 1.1 0.3 0.5 -0.2
Chronotype (morning person) 0.4 0.9 2.2 -0.1 -0.9 0.8 1.5
Hair Pigment 0.0 0.6 2.4 -0.3 -0.0 0.1 1.6
Tanning 0.2 2.0 5.5 -0.7 1.3 -2.4 -0.4
Hand grip strength (left) 0.2 0.6 1.5 0.2 -1.2 -0.8 0.5
Number of treatments/medications taken 0.5 1.0 2.2 -1.1 -1.5 -0.2 0.7
Average weekly spirits intake 0.4 0.4 0.7 -0.8 0.1 -0.7 0.9
Sensitivity / hurt feelings 0.1 0.2 0.8 -0.1 0.9 -0.3 0.1
Frequency of depressed mood in last 2 weeks 1.4 1.9 5.7 0.8 1.0 -2.4 0.7
Hearing difficulty/problems: Yes 1.0 1.5 2.4 -1.4 -1.6 -0.3 -1.2
Relative age of first facial hair 0.2 0.5 1.5 0.2 0.2 -1.2 0.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.4 -1.3 -1.6 -0.8 -0.8
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.1 0.1 -0.5 1.3 1.8
Ever had hysterectomy (womb removed) 0.6 0.7 1.3 -1.0 -0.3 0.6 1.2
Systolic blood pressure, automated reading 0.3 0.8 1.4 -1.2 -0.6 -1.2 -0.0
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.0 0.6 1.3 -0.6 -1.4
Angina 1.1 1.4 3.2 0.0 -1.4 -0.6 -1.8
Medication for hormone replacement therapy 0.1 0.2 0.3 -0.1 -0.6 0.3 -0.4
Vitamin and mineral supplements 0.4 0.5 1.2 -0.2 -0.9 -1.1 -0.3
Supplements: Zinc 1.0 1.1 1.9 0.8 1.2 0.3 1.4
Medication: Co-codamol 0.3 0.4 1.0 -0.5 -1.0 -0.1 -0.5
Medication: Metformin 1.0 1.4 3.0 0.1 -0.8 -1.3 -1.7
Diabetes (father) 1.0 1.2 3.3 0.7 0.5 1.8 0.9
Diabetes (mother) 1.3 1.7 3.4 -0.7 -1.5 1.9 0.7
Severe depression (siblings) 1.5 1.7 3.7 0.5 1.9 0.4 -1.7
Pack years adult smoking proportion 1.7 2.5 4.5 0.1 1.6 -2.1 -1.8
Impedance of leg (right) 1.6 7.6 16.2 0.6 3.4 -4.0 -1.5
Leg fat-free mass (left) 1.0 5.4 13.5 -1.0 -2.6 3.7 0.5
Trunk fat percentage 0.4 1.5 3.2 -1.3 -1.8 0.7 0.8
Hand grip strength (right) 0.6 1.5 2.2 0.8 -1.5 1.1 1.4
Townsend deprivation index at recruitment 0.9 1.3 4.1 -0.7 -0.4 -0.7 2.0
Current tobacco smoking 0.4 0.6 1.7 0.7 0.2 -0.6 -1.3
Average weekly fortified wine intake 1.0 1.1 3.3 -1.0 -0.6 1.8 0.0
Maternal smoking around birth 0.7 1.1 1.4 1.2 1.2 -0.7 -1.0
Fed-up feelings 1.1 2.1 3.6 1.3 1.2 -1.9 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 -0.6 1.0 -0.6 0.0
Relative age voice broke 0.3 0.5 1.3 0.3 -0.2 -0.7 -1.1
Taking other prescription medications 0.8 1.2 1.9 -1.2 -1.4 1.0 -0.7
Age when periods started (menarche) 1.3 3.0 5.9 0.6 2.3 -0.7 -2.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.2 -0.5 -1.1 1.1 0.4
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.4 7.9 2.7 2.8 -2.5 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 0.5 0.0 -0.2 -1.0
Qualifications: CSEs or equivalent 1.0 1.3 4.2 2.0 -1.0 -0.1 -0.4
Serious illness, injury or assault to yourself 1.6 2.0 5.8 -0.4 -1.4 -0.3 -2.4
High blood pressure 0.3 0.9 2.0 -1.4 -1.1 -0.6 0.2
Hayfever, allergic rhinitis or eczema 1.2 2.7 6.1 -1.4 -0.6 1.6 2.5
Multivitamins +/- minerals 0.3 0.4 1.4 -0.1 0.6 1.2 0.0
Stomach or abdominal pain in last month 1.2 1.4 4.2 2.1 -0.3 -0.2 -1.2
Supplements: Glucosamine 0.8 1.1 2.8 1.1 -0.6 1.7 -0.3
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.4 1.5 -0.6 1.6 0.3
Medication: Atenolol 0.6 0.7 2.3 -0.5 -0.2 0.4 -1.5
Medication: Levothyroxine sodium 0.3 0.4 1.0 -0.1 -0.3 -0.8 1.0
Sitting height 0.4 2.6 6.2 0.1 2.5 1.4 -1.4
Chronic bronchitis/emphysema (father) 0.8 1.0 2.9 -0.8 0.3 -1.7 -0.4
High blood pressure (mother) 0.3 0.4 1.2 0.5 0.3 -1.1 -0.0
Body mass index (BMI) 2.0 8.5 19.0 -1.6 -4.4 2.5 2.5
Impedance of leg (left) 1.3 6.3 15.1 0.4 3.0 -3.9 -0.8
Leg predicted mass (left) 1.1 5.6 14.4 -1.0 -2.6 3.8 0.5
Trunk fat mass 0.7 3.2 5.5 -1.7 -2.4 1.7 1.2
Waist circumference 1.5 5.3 11.1 -2.1 -3.3 2.0 1.4
Number of incorrect matches in round 0.2 0.3 0.7 0.1 0.9 -0.2 -0.5
Past tobacco smoking 0.5 0.9 1.3 1.1 1.1 0.4 1.0
Alcohol usually taken with meals 0.9 1.5 4.1 -0.2 2.0 1.1 0.8
Nervous feelings 0.8 1.5 5.6 -2.4 -0.5 0.2 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 0.0 0.3 -0.7 -0.4
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.4 -0.1 -0.2 0.5
Hair/balding pattern: Pattern 2 0.6 0.8 2.9 -0.6 -0.2 -0.3 1.7
Had menopause 1.3 1.6 3.8 -1.9 -0.1 0.9 1.4
Had other major operations 1.0 1.3 3.5 -0.9 -1.9 0.8 -0.2
Forced vital capacity (FVC) 0.4 1.5 5.7 -0.0 2.4 0.5 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 7.1 1.9 2.7 -2.6 0.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.5 -1.6 -0.3 0.5 1.2
Qualifications: None of the above 0.9 2.0 4.9 -2.2 -1.0 -0.4 1.4
Financial difficulties in last 2 years 0.3 0.3 0.8 0.9 0.7 -0.3 -0.1
Mouth/teeth dental problems 0.5 0.8 1.4 1.0 -0.0 1.2 0.8
Heart attack 1.1 1.4 3.3 -0.6 -1.3 -1.8 -0.7
Allergy 1.1 2.5 4.0 1.5 1.2 -1.6 -2.0
Pain all over the body in last month 0.8 0.9 2.7 -0.5 -1.6 0.8 -0.1
Diabetes (self-reported) 0.4 0.6 1.7 -0.1 -0.8 -0.2 -1.3
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.1 -0.4 -0.3 1.2 1.4
Medication: Ramipril 0.8 1.1 3.4 -0.7 -1.8 0.5 -0.4
Medication: Simvastatin 1.0 1.4 2.4 -0.3 -1.0 -1.6 -1.4
Fluid intelligence score 1.7 3.5 9.1 -0.3 -3.0 1.7 -1.3
Illnesses of siblings 2.0 2.9 5.4 2.3 0.8 1.0 -2.1
Neuroticism score 0.1 0.1 0.3 -0.6 0.3 -0.3 0.1
Weight 1.2 6.0 10.6 -1.8 -3.3 2.7 1.7
Impedance of arm (right) 3.2 14.7 23.2 1.9 4.8 -4.0 -4.0
Arm fat percentage (right) 0.6 2.4 6.6 -1.1 -2.6 0.6 1.2
Trunk fat-free mass 0.8 4.8 11.0 -1.4 -2.2 3.3 1.3
Hip circumference 1.4 6.0 11.6 -1.2 -3.4 2.5 2.1
Time employed in main current job 0.9 1.0 2.2 -1.0 1.0 -1.5 -0.2
Alcohol intake versus 10 years previously 0.8 1.2 3.6 -0.3 -1.9 -0.4 1.0
Father’s age at death 0.2 0.3 1.3 -0.2 0.0 1.1 0.0
Worrier / anxious feelings 0.8 1.6 4.1 -2.0 -1.0 0.2 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 2.2 -1.0 -1.4 0.8 1.5
Falls in the last year 0.8 1.1 2.0 -0.7 -0.3 -1.4 -1.4
Hair/balding pattern: Pattern 3 0.4 0.5 1.7 0.6 -1.3 -0.1 0.1
Number of live births 1.0 1.5 3.7 -1.1 -1.9 0.4 0.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 3.5 0.3 1.9 0.5 -0.8
Pulse rate 0.1 0.2 0.8 -0.3 0.9 -0.1 -0.0
Happiness 0.3 0.4 0.6 -0.8 0.5 -0.5 0.7
Noisy workplace 0.8 1.0 3.1 -0.8 -0.4 -1.8 0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.1 -0.1 -0.3 -0.1 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.3 -0.4 -1.1 -0.6 -0.3
Mouth/teeth dental problems: Dentures 0.7 1.1 3.2 -1.8 -1.1 -0.4 -0.2
Asthma 1.1 2.1 4.9 -1.5 -2.2 0.9 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.9 0.0 1.0 -0.4 -0.5
Medication: Cholesterol lowering 0.2 0.4 0.9 0.1 -0.7 -1.0 0.2
Depression (self-reported) 0.1 0.1 0.4 0.1 -0.1 -0.6 0.0
Medication: Lansoprazole 1.6 1.9 3.8 -1.3 -1.9 1.4 -0.4
Prospective memory result 0.6 0.8 2.1 0.2 0.6 -1.4 -0.8
Lung cancer (father) 2.0 2.3 4.4 -1.4 -1.0 2.1 -1.5
Illnesses of mother 1.3 1.6 2.7 -1.6 -1.7 1.0 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.2 0.0 1.1 0.4 0.1
Pulse wave Arterial Stiffness index 0.4 0.5 0.8 -0.4 -0.7 -0.6 0.9
Impedance of arm (left) 2.2 10.4 16.3 1.9 4.0 -3.0 -3.6
Arm fat mass (right) 1.1 4.3 9.0 -1.3 -3.0 1.9 1.7
Trunk predicted mass 0.8 4.7 10.8 -1.3 -2.2 3.3 1.3
Standing height 0.2 1.9 3.8 -0.6 1.9 0.9 -1.6
Length of working week for main job 0.4 0.4 1.4 0.4 -1.2 0.2 -0.4
Exposure to tobacco smoke at home 1.0 1.1 2.8 0.3 1.7 0.3 -1.3
Breastfed as a baby 0.3 0.3 1.1 -0.4 0.1 1.1 0.0
Tense / ‘highly strung’ 0.4 0.6 2.0 0.5 -0.3 0.1 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.6 -1.9 -1.1 -0.2 1.6
Hair/balding pattern: Pattern 4 1.4 3.3 5.7 -1.0 -2.4 2.1 1.5
Birth weight of first child 0.9 1.6 3.2 -1.8 0.5 -1.8 0.2
Peak expiratory flow (PEF) 0.4 0.8 3.1 0.1 -0.4 1.7 0.3
Pulse wave reflection index 0.6 0.8 2.3 -0.0 -0.8 -0.5 1.5
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.8 0.2 -0.1 1.4 0.7
Loud music exposure frequency 1.3 1.5 3.6 1.3 1.9 -0.4 -0.6
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.3 1.8 0.4 -0.4 -1.0
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.8 0.2 0.3 -1.7 -1.1
Blood clot in the leg (DVT) 2.0 2.6 4.8 1.2 -2.2 2.0 0.1
Medication: Paracetamol 0.4 0.6 1.0 -0.9 0.8 -1.0 -0.2
Headache pain in last month 0.3 0.4 1.0 0.7 -0.0 -0.6 -1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 1.2 0.9 0.5 -0.5
Glaucoma (self-reported) 0.2 0.2 0.5 0.7 -0.6 0.1 -0.0
Gout (self-reported) 1.6 2.2 8.3 2.9 0.1 -0.4 -0.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.0 1.3 -0.5 -1.0 1.4
Medication: Amlodipine 0.2 0.3 0.5 0.3 0.7 0.7 0.5
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 0.3 -0.8 -0.8 -0.3
Birth weight 1.3 2.9 6.2 -1.4 0.7 -1.7 2.5
Chronic bronchitis/emphysema (mother) 3.1 3.6 5.2 2.0 2.3 -0.6 -2.2
High blood pressure (siblings) 2.5 3.6 8.5 -1.6 0.4 -1.7 2.9
Forced vital capacity (FVC), Best measure 0.2 0.8 2.7 -0.4 1.6 0.4 0.2
Body fat percentage 0.7 2.7 5.5 -1.5 -2.3 0.7 1.7
Leg fat percentage (right) 1.2 4.5 8.7 -1.9 -2.4 0.4 3.0
Arm fat-free mass (right) 1.6 8.4 18.3 -1.3 -3.0 4.3 2.1
Exposure to tobacco smoke outside home 0.7 1.0 3.1 1.8 0.6 -0.7 -0.2
Comparative body size at age 10 1.4 3.9 9.4 -1.1 -3.1 1.1 1.9
Number of full brothers 1.5 1.9 6.2 -2.5 -0.3 -1.1 0.5
Worry too long after embarrassment 0.6 1.0 1.8 -0.6 1.4 1.3 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.8 0.3 -1.1 -1.3 0.2
Wheeze or whistling in the chest in last year 0.4 0.7 1.1 0.2 -0.8 1.0 -1.1
Number of children fathered 0.3 0.4 0.9 0.3 -1.0 0.5 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.4 -0.4 0.0 -0.3 0.6
Age at first live birth 1.0 1.8 3.4 -0.3 1.8 -1.2 -1.5
Pulse wave peak to peak time 0.5 0.6 1.0 0.3 1.0 0.7 -1.0
Health satisfaction 0.3 0.4 1.2 -1.1 -0.4 0.2 0.3
Shortness of breath walking on level ground 0.2 0.3 0.7 -0.8 0.3 -0.2 -0.6
Qualifications: College or University degree 0.1 0.4 0.8 -0.4 -0.8 0.9 -0.3
Eye problems/disorders: None of the above 1.2 1.4 2.6 -1.3 -1.6 0.3 -1.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.7 -1.3 -0.5 -1.0 -0.9
Emphysema/chronic bronchitis 1.5 1.6 3.8 -0.6 -0.1 -1.9 1.6
Medication for pain relief, constipation, heartburn 0.6 1.0 1.6 0.7 1.3 -1.1 0.8
Neck or shoulder pain in last month 0.8 1.2 4.1 -0.5 2.0 -0.5 0.3
Medication: Blood pressure 0.3 0.5 1.3 -1.2 -0.6 -0.6 -0.3
Angina (self-reported) 0.9 1.2 2.7 -0.0 -1.4 -0.5 -1.6
Migraine (self-reported) 0.3 0.3 1.1 0.3 -0.3 1.0 -0.4
Medication: Ibuprofen 0.3 0.4 1.3 -0.0 1.1 -0.4 -0.5
Medication: Allopurinol 2.2 3.0 7.4 2.7 1.1 -0.1 -1.8
Medication: Omeprazole 0.8 0.9 2.4 -1.6 -1.0 0.6 -0.1
Medication: Seretide 50 evohaler 0.4 0.4 1.3 0.1 -1.2 0.3 -0.5
Mean time to correctly identify matches 0.7 1.3 4.5 -2.1 0.5 0.2 0.6
Heart disease (mother) 0.7 0.8 2.1 -0.5 0.7 -1.4 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.4 4.1 9.4 -0.3 -3.1 2.0 1.7
Whole body fat mass 1.1 4.5 8.0 -1.8 -2.8 2.0 1.7
Leg fat mass (right) 1.3 5.2 9.4 -1.9 -3.1 1.8 2.2
Arm predicted mass (right) 1.8 9.0 20.1 -1.4 -3.1 4.5 2.1
Pulse rate, automated reading 0.2 0.6 1.4 -0.1 1.2 0.2 -0.9
Alcohol intake frequency. 1.1 2.5 7.2 -0.4 -1.6 0.3 2.7
Comparative height size at age 10 0.7 3.8 8.6 -2.5 -0.6 2.9 -0.2
Number of full sisters 0.2 0.3 1.0 -0.0 1.0 -0.0 0.5
Suffer from ‘nerves’ 0.2 0.3 0.8 -0.6 -0.4 0.9 0.1
Overall health rating 0.7 1.5 3.5 -1.4 -1.9 -0.5 -0.4
Chest pain or discomfort 0.5 0.7 0.9 -0.2 -1.0 -0.9 -0.9
Had major operations 2.5 3.0 4.2 -2.0 -1.8 0.4 2.0
Age at last live birth 1.4 2.0 4.7 -0.0 1.8 -2.2 -0.0
Family relationship satisfaction 0.4 0.5 1.2 -0.6 -0.2 -1.1 -0.4
Leg pain on walking 0.8 1.0 3.1 0.6 0.6 -1.8 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.9 1.0 -0.2 -0.3 -0.1
Commuting to job workplace: Car/motor vehicle 0.8 1.0 2.0 0.7 0.7 1.4 0.9
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 3.4 -1.2 -0.1 0.0 1.9
Medication: Aspirin 1.8 2.4 5.4 0.4 -2.3 1.6 -1.3
Supplements: Vitamin C 1.0 1.2 3.2 0.9 1.8 0.8 -0.3
Knee pain experienced in last month 0.9 1.4 2.7 -0.1 -0.9 1.5 -1.6
Hypertension (Self-reported) 0.2 0.7 1.4 -1.1 -1.2 -0.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 4.0 -2.0 -0.3 1.6 0.5
Illnesses of father: Heart disease 0.3 0.5 0.9 0.5 -0.9 -0.7 -0.6
Illnesses of siblings: Diabetes 1.9 2.4 3.9 -2.0 -1.7 1.6 0.1
Smoking status: Previous 0.7 1.1 2.1 -1.4 -1.3 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.3 -0.2 0.4 -1.5 -1.4
Whole body fat-free mass 1.0 5.6 13.4 -1.3 -2.5 3.7 1.1
Leg fat-free mass (right) 1.1 6.0 15.3 -1.1 -2.7 3.9 0.6
Arm fat percentage (left) 0.8 3.1 8.4 -0.9 -2.9 1.3 1.2
Average weekly red wine intake 0.8 1.1 2.6 0.4 1.6 -0.5 -1.2
Handedness (chirality/laterality): Left-handed 2.7 3.3 11.0 -3.3 -0.3 1.4 -0.2
Mood swings 0.7 1.3 2.4 -1.3 -1.5 0.1 1.0
Loneliness, isolation 0.8 1.1 2.6 0.3 1.6 -1.2 0.0
Long-standing illness, disability or infirmity 0.6 0.9 2.0 -1.4 -1.2 0.2 0.3
Ever had bowel cancer screening 0.1 0.2 0.6 -0.0 0.0 -0.2 -0.8
Diabetes diagnosed by doctor 0.6 0.9 1.9 0.0 -1.3 0.4 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.9 -0.0 -0.3 -1.7 -0.1
Friendships satisfaction 0.9 1.1 2.7 -1.0 0.8 -1.6 0.1
Qualifications: nursing, teaching 0.4 0.7 1.3 -0.0 -1.2 0.7 0.9
Commuting to job workplace: Walk 0.9 1.0 1.5 -1.2 -1.1 1.1 0.5
Eye problems/disorders: Cataract 1.1 1.3 4.5 0.7 2.1 -0.3 0.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.4 0.6 0.4 0.0 0.0
Medication for cholesterol 0.4 0.7 1.0 1.0 1.0 -0.5 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 6.3 0.4 -1.2 2.5 0.2
Back pain experienced in last month 1.0 1.4 2.4 -1.2 0.6 1.2 -1.6
Mineral and other dietary supplements 1.9 2.5 6.7 -1.2 1.4 -2.6 -0.4
Breast cancer (self-reported) 0.5 0.6 1.5 0.1 0.7 -0.7 -1.2
Asthma (self-reported) 1.2 2.3 5.5 -1.6 -2.3 0.9 -0.5
Osteoporosis (self-reported) 0.5 0.6 1.4 -0.7 0.1 0.6 1.2
Osteoarthritis (self-reported) 1.0 1.3 3.4 -0.6 -1.8 0.4 -1.0
Medication: Aspirin 1.4 1.8 3.9 0.2 -2.0 1.0 -1.5
Medication: Gliclazide 0.8 0.9 1.9 0.3 0.5 -1.4 -1.1
Illnesses of father: None of the above (group 1) 0.5 0.6 1.4 -0.3 0.6 -0.7 1.2
Smoking status: Current 0.2 0.4 1.1 0.5 0.3 -0.3 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.6 -1.0 -0.9 1.6 0.9
Whole body water mass 1.0 5.7 13.8 -1.2 -2.5 3.7 1.1
Leg predicted mass (right) 1.2 6.3 16.1 -1.1 -2.7 4.0 0.6
Arm fat mass (left) 1.1 4.7 9.9 -1.1 -3.1 2.3 1.5
Number of self-reported non-cancer illnesses 1.1 2.0 6.1 -1.1 -2.5 -0.7 0.4
Average weekly champagne plus white wine intake 1.7 2.3 8.0 -0.3 2.8 -1.0 -0.5
Miserableness 0.7 1.1 3.6 -0.4 -0.9 -0.0 1.9
Guilty feelings 0.6 0.9 2.9 -0.2 0.6 0.6 1.7
Wears glasses or contact lenses 2.1 2.4 5.7 -2.4 -1.7 1.0 -0.4
Ever taken oral contraceptive pill 1.1 1.2 2.8 1.3 -0.1 -0.6 -1.7
Hearing aid user 1.1 1.2 3.9 0.4 -0.8 0.2 -2.0
Mother’s age at death 0.4 0.5 1.3 0.2 0.8 -0.1 -1.1
Financial situation satisfaction 0.5 0.6 1.9 0.3 0.6 -1.4 -0.2
Tinnitus: Yes, now most or all of the time 0.6 0.6 1.2 -1.1 -1.0 0.4 -0.5
Commuting to job workplace: Public transport 0.2 0.3 0.5 -0.4 0.0 -0.6 -0.7
Eye problems/disorders: Glaucoma 0.4 0.5 1.3 1.1 0.4 0.7 0.2
Medication: Blood pressure 0.3 0.6 0.9 -0.6 -1.0 0.6 0.9
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 -0.6 0.6 0.0 0.1
Supplements: Fish oil (including cod liver oil) 1.4 1.8 3.8 0.7 -1.1 1.9 1.3
High cholesterol (Self-reported) 0.6 1.1 2.5 -1.6 -1.2 -0.3 -0.6
Medication: Bendroflumethiazide 0.3 0.5 1.7 -0.2 -0.0 -1.3 -0.5
Medication: Paracetamol 0.9 1.4 3.4 -1.4 0.3 -1.9 0.2
Medication: Lisinopril 0.2 0.3 0.5 -0.3 0.7 -0.2 0.7
Medication: Atorvastatin 1.4 1.7 5.9 -0.5 -0.7 -0.4 2.4
Illnesses of father: High blood pressure 1.6 2.0 5.2 0.5 -1.6 2.3 -0.2
Alcohol drinker status: Never 1.4 1.7 6.4 0.2 -2.5 0.4 0.1
Ever smoked 0.5 0.9 3.4 -0.2 0.3 -0.1 -1.9
Basal metabolic rate 1.0 5.8 12.2 -1.3 -2.8 3.5 1.2
Leg fat percentage (left) 1.5 5.5 10.1 -2.0 -2.7 0.7 3.2
Arm fat-free mass (left) 1.2 6.0 11.5 -1.5 -2.5 3.4 2.0
Number of operations (self-reported) 2.1 3.1 5.2 -1.0 -2.0 1.5 2.3
Average weekly beer plus cider intake 0.5 0.7 1.3 -1.0 -0.6 -0.2 1.1
Irritability 0.9 1.5 2.9 -1.4 -0.8 0.6 -1.7
Risk taking 1.3 1.9 2.9 1.7 1.0 -1.4 -1.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.0 -0.4 0.2 1.0 0.8
Fractured/broken bones in last 5 years 0.2 0.2 0.6 -0.2 0.8 -0.3 0.5
Age started oral contraceptive pill 1.3 1.7 3.4 0.9 0.5 1.5 1.9
Diastolic blood pressure, automated reading 0.2 0.8 2.0 -1.4 0.5 -0.9 0.1
Ever depressed for a whole week 0.9 1.1 2.2 -1.5 -0.4 0.3 1.5
Unable to work because of sickness or disability 0.3 0.4 0.7 0.7 -0.8 0.1 -0.8
Commuting to job workplace: Cycle 0.5 0.7 1.8 -0.3 0.8 -1.4 -0.1
Myopia 1.5 2.1 4.3 -2.1 -0.7 1.4 -1.4
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.4 1.6 1.4 1.1 -0.1
Cholesterol lowering medication 1.0 1.5 2.7 -1.3 -1.0 -0.7 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 6.4 -2.5 -1.1 -0.1 0.2
Pain experienced in last month 0.8 1.3 3.9 -0.6 -0.5 -0.9 2.0
Supplements: Calcium 0.7 0.8 2.1 1.5 0.9 -0.3 -0.2
Basal cell carcinoma (self-reported) 1.3 1.5 2.0 1.0 1.4 -1.2 -1.2
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.4 -0.8 -1.5 -1.5 -0.7
Deep venous thrombosis (DVT) (self-reported) 2.1 2.6 5.1 1.1 -2.1 2.3 -0.2
Heart disease (siblings) 1.2 1.4 4.4 -2.1 -1.0 0.2 -0.4
Alcohol drinker status: Previous 0.5 0.5 1.7 0.3 0.6 -1.3 -0.1
Pack years of smoking 1.8 2.6 5.0 -0.1 1.4 -2.2 -1.8
Impedance of whole body 1.8 9.2 15.2 1.4 3.9 -3.6 -2.6
Leg fat mass (left) 1.6 6.2 11.2 -1.9 -3.4 2.1 2.4
Arm predicted mass (left) 1.3 6.5 12.5 -1.7 -2.7 3.5 1.8