Hub : Genes

HPGD

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1540	0.0370	1.2e-07	0.073	0.072	0.067	0.085	0.081	2.9e-09	4.0e-09	1.3e-08	1.4e-10	3.9e-10
2	GTEx	Adrenal Gland	0.4815	0.0940	5.1e-04	0.050	NA	0.034	NA	0.049	6.9e-03	NA	2.2e-02	NA	7.8e-03
3	GTEx	Cells Transformed fibroblasts	0.2040	0.0630	9.9e-04	0.074	NA	0.064	NA	0.103	3.4e-06	NA	1.5e-05	NA	4.2e-08
4	GTEx	Esophagus Muscularis	0.2220	0.0690	1.2e-03	0.082	NA	0.115	NA	0.144	1.2e-05	NA	1.8e-07	NA	4.5e-09
5	GTEx	Whole Blood	0.1910	0.0490	7.1e-05	0.141	NA	0.118	NA	0.133	6.4e-13	NA	5.8e-11	NA	3.0e-12
6	METSIM	Adipose	0.0719	0.0246	4.1e-04	0.049	0.024	0.036	0.033	0.034	6.6e-08	1.3e-04	3.3e-06	7.6e-06	6.1e-06
7	YFS	Blood	0.2119	0.0292	0.0e+00	0.116	0.172	0.177	0.179	0.174	5.4e-36	8.6e-54	1.0e-55	4.5e-56	1.4e-54
8	TCGA	Colon Adenocarcinoma	0.1010	0.0500	6.8e-03	0.064	0.019	0.022	NA	0.049	1.4e-04	2.7e-02	1.9e-02	NA	8.6e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0882	0.0319	1.3e-04	0.031	0.037	0.007	NA	0.032	1.8e-04	5.0e-05	4.5e-02	NA	1.4e-04
10	TCGA	Prostate Adenocarcinoma	0.0609	0.0285	3.6e-03	0.000	0.021	0.025	NA	0.006	2.9e-01	2.7e-03	1.1e-03	NA	7.5e-02
11	TCGA	Stomach Adenocarcinoma	0.0820	0.0380	5.6e-03	0.011	0.009	0.004	NA	0.004	5.1e-02	6.6e-02	1.4e-01	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	2.2	-1.0	1.4	0.5	0.6	-1.1	-0.9	-0.7	-1.5	-0.0	-0.1	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	1.8	-1.0	1.4	0.1	0.1	0.6	-0.7	-0.0	-0.2	-0.4	-0.8	-0.4
Depressed Affect (Nagel 2018)	0.8	1.8	5.1	-1.5	2.3	1.9	-1.0	1.5	-0.2	1.4	-0.3	-1.8	-0.4	0.0
Depression (Nagel 2018)	0.3	0.5	1.7	0.1	-0.2	1.3	-0.9	1.2	0.1	0.3	-0.5	-0.0	-0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.9	2.8	10.7	1.0	-1.0	-1.2	1.1	2.0	1.3	3.3	-0.3	-1.4	-1.2	-2.5
Neuroticism (Nagel 2018)	0.6	1.5	5.6	-0.6	1.6	1.2	-0.6	-0.4	0.8	2.0	0.4	-2.4	-0.9	-0.7
Schizophrenia (2018)	0.3	0.5	2.8	-0.5	0.6	-0.4	-0.3	1.7	-0.2	0.6	0.9	-0.5	-0.9	0.2
Schizophrenia vs Biploar Disorder	0.8	1.0	3.7	1.9	-0.6	-1.1	-0.7	0.8	1.2	-1.2	0.1	0.6	-0.1	-1.3
Worry (Nagel 2018)	0.8	1.8	7.1	-1.1	0.3	1.5	0.8	-0.1	1.7	2.7	-0.1	-1.8	-1.0	-1.1
Alzheimer’s Disease (in mother)	1.3	1.5	7.6	0.7	1.6	1.5	-0.9	0.1	0.0	1.3	0.1	-2.8	-0.0	1.0
Alzheimer’s Disease (in father)	0.4	0.5	1.9	-0.6	1.1	0.1	-1.4	0.6	0.3	-0.1	0.8	0.3	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	4.7	0.2	2.2	1.3	-0.9	0.7	0.8	1.0	0.7	-1.8	0.2	1.3
Crohns Disease (2017)	0.5	1.0	4.4	0.9	1.0	-0.3	-0.5	-0.9	1.1	-0.2	1.0	-1.2	2.1	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	0.4	1.1	0.6	-1.2	-0.4	0.1	-0.3	0.2	-0.8	1.2	-0.2
Ulcerative Colitis (UC)	0.2	0.5	1.9	-0.7	0.9	1.4	-1.1	-0.1	-0.6	-0.1	-0.5	0.0	0.2	-0.3
Major Depression (MDD)	0.7	0.8	4.4	0.0	-0.3	0.5	-1.4	-0.0	0.4	-1.1	-2.1	-0.1	-0.7	-0.9
Reaction Time	0.7	1.4	4.7	-0.5	0.5	-1.3	1.4	-0.6	-0.5	-1.5	1.1	2.2	-0.9	-1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.2	9.6	1.4	-1.3	-0.5	0.5	0.7	1.6	3.1	-0.4	-0.6	-1.1	-2.3
Breast Cancer	0.7	1.7	6.4	-0.9	-0.7	-1.3	0.5	1.3	1.9	0.7	2.5	1.8	0.2	0.2
Ovarian Cancer	3.2	4.2	11.5	2.1	-1.7	-1.6	-2.3	1.1	-2.7	1.1	1.3	-2.1	-2.1	3.4
Prostate Cancer	0.4	0.6	2.6	-0.8	0.8	0.4	-0.1	1.6	-0.9	0.4	0.6	0.3	0.4	0.8
Age at First Birth	0.8	1.1	3.5	0.5	1.3	-0.1	-1.2	-1.5	-0.6	0.6	1.2	-1.9	-0.6	0.6
Bipolar Disorder (2011)	0.2	0.2	1.2	-1.1	0.4	0.2	0.2	-1.0	-0.2	0.3	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.5	2.0	11.8	-1.9	1.1	-0.8	-1.2	3.4	-0.3	0.8	1.3	-0.2	-0.7	-0.4
Coronary Artery Disease (CAD)	0.9	1.0	2.5	1.3	-0.8	1.3	1.0	-0.3	0.4	-1.3	-0.7	0.7	1.6	1.1
Crohns Disease (2012)	0.5	0.9	2.9	0.0	1.0	-1.3	-0.3	-1.1	-0.7	-0.6	0.4	-1.3	1.7	-0.1
Mean Putamen Volume	0.5	0.6	1.6	0.6	-0.6	1.1	1.1	-1.3	0.6	0.1	-0.3	0.0	0.9	0.7
Fasting Glucose	0.6	0.7	1.9	-1.4	1.0	0.9	0.3	1.0	0.4	-0.2	-0.2	0.0	1.2	1.3
HbA1C	1.2	1.4	4.2	-1.9	0.7	0.8	1.4	0.4	-0.1	2.0	0.8	-0.9	1.0	1.3
HDL Cholesterol	0.7	1.1	3.6	1.7	-0.1	1.9	1.3	-0.5	1.3	0.0	-1.0	0.7	0.2	-0.8
LDL Cholesterol	0.3	0.4	1.4	-0.0	-1.2	0.1	-0.4	-1.1	-0.2	-0.6	-0.5	-0.8	0.9	-0.3
Lupus	0.7	1.0	5.0	1.0	0.6	1.2	-2.2	-1.0	-0.1	-0.9	-0.3	0.3	0.5	1.1
Neuroticism (2016)	0.8	1.1	2.9	-1.5	1.6	0.9	-0.2	-0.5	0.1	-0.0	0.3	-1.2	1.7	1.4
Primary Biliary Cirrhosis	0.7	1.1	5.3	-0.4	0.4	-0.1	-2.3	1.1	-0.6	-1.8	-0.1	0.8	-0.7	0.6
Rheumatoid Arthritis	0.4	0.5	1.4	1.2	-0.8	0.3	-0.6	-0.7	-1.1	-0.8	0.8	-0.1	-0.2	0.6
Schizophrenia (2014)	0.3	0.6	2.1	-1.4	0.6	0.1	0.4	1.5	0.4	-0.5	0.1	0.4	-0.4	-1.0
Triglycerides	1.7	2.8	6.8	-2.0	1.0	-1.1	-1.5	1.8	-1.4	2.6	0.5	-2.5	-2.0	0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	-0.9	0.3	1.1	0.8	0.1	0.4	-0.9	-0.2	0.6	0.7	0.5
Ulcerative Colitis	0.5	0.8	3.8	-0.1	0.1	1.3	-0.5	-0.1	-0.9	-0.6	-1.9	0.7	0.2	-1.1
Blood Eosinophil Count	0.2	1.4	5.7	-1.1	-0.5	-0.6	1.3	-1.4	2.4	0.6	1.4	0.2	-0.2	-1.2
Blood Platelet Count	0.1	0.9	4.0	0.3	-0.7	1.4	0.6	-2.0	0.5	1.2	-0.7	-0.8	-0.3	0.4
Blood Red Count	0.0	0.3	0.8	-0.3	-0.1	0.0	-0.9	-0.1	0.2	-0.2	-0.3	0.8	-0.9	-0.5
Blood White Count	0.2	1.3	4.5	0.9	0.0	1.4	-1.0	-1.0	-1.6	0.7	0.8	-1.3	0.1	2.1
Heel T-Score	0.1	0.4	1.9	-0.6	-0.3	-1.1	1.4	-0.1	-0.6	0.5	0.2	0.5	0.5	-0.0
BMI	0.3	1.9	7.3	-0.3	1.2	0.8	-2.4	-0.5	-0.5	-1.5	1.5	-0.5	-0.6	2.7
Height	0.1	1.8	7.2	-1.9	-0.1	-0.6	1.6	2.7	1.1	0.9	1.2	0.8	1.5	-0.2
Waist Hip Ratio (WHR)	0.2	0.9	4.4	-0.7	0.6	-1.1	0.2	2.1	-0.5	-0.5	-0.1	0.1	-0.6	-1.5
Systolic Blood Pressure	0.2	0.8	5.1	0.9	-2.3	0.0	0.1	-0.8	0.8	0.2	-0.9	0.4	0.2	-0.5
Smoking Status	0.1	0.4	0.8	-0.8	-0.2	-0.3	0.7	0.4	-0.9	0.8	0.5	-0.8	-0.3	0.3
Allergy or Eczema	0.2	0.5	2.0	0.3	0.8	-0.8	-0.5	1.4	0.3	-0.3	-0.2	0.7	-0.5	-1.1
Cardiovascular Disease	0.3	1.1	2.3	-0.8	1.4	-0.2	-0.3	-0.9	1.2	0.4	1.5	-1.4	1.3	1.0
Hypothyroidism (self reported)	0.6	1.5	8.4	0.6	-0.5	-2.9	-0.1	0.2	-1.2	-1.1	1.6	1.4	-0.2	0.1
Respiratory disease	0.3	0.6	1.6	-0.6	-0.1	-0.8	-1.0	0.6	-0.6	1.3	-0.2	-1.0	-1.2	0.2
Type 2 Diabetes (T2D) (2018)	1.4	2.6	9.8	-0.3	0.8	0.4	-1.7	0.2	-3.1	-2.3	0.3	0.2	1.6	2.7
Lung FEV1/FVC ratio	0.5	2.3	8.2	1.7	-0.1	-1.0	-2.9	-2.3	-1.1	-0.9	0.2	-0.5	-2.1	0.8
Lung FVC	0.4	1.8	7.3	-0.5	1.8	-0.6	1.4	1.6	1.1	2.7	0.8	-1.0	0.3	-1.1
Neuroticism	0.4	1.0	3.4	-0.1	0.6	1.6	-0.7	-0.5	0.4	1.5	0.6	-1.9	-1.0	-0.3
Chronotype (morning person)	0.3	0.7	2.0	-0.3	0.7	0.7	-1.1	-0.7	-1.1	-0.8	-0.7	-0.9	0.4	1.4
Hair Pigment	0.0	0.5	1.4	0.2	0.4	1.0	1.1	-0.3	0.2	0.8	1.2	-0.9	0.5	0.5
Tanning	0.1	1.2	2.8	-0.6	1.5	1.7	-1.0	0.2	-1.6	-1.4	0.2	1.4	-0.2	0.8
Hand grip strength (left)	0.1	0.3	0.9	0.2	-0.3	-0.8	-0.1	-0.7	-0.2	0.6	0.6	-0.9	-0.4	-0.3
Number of treatments/medications taken	0.4	0.8	2.9	-0.3	-1.3	0.4	-1.1	0.3	0.5	-0.4	-1.7	0.9	-1.0	-0.4
Average weekly spirits intake	0.4	0.4	1.6	-0.6	-0.3	0.1	0.5	0.1	-1.3	-1.0	-0.8	0.6	-0.8	-0.1
Sensitivity / hurt feelings	1.0	1.7	4.4	1.5	1.0	-0.3	-1.9	-1.1	0.7	1.2	1.9	-2.1	-0.9	-0.2
Frequency of depressed mood in last 2 weeks	1.9	2.7	9.5	-0.4	0.8	1.6	-2.6	1.3	-1.9	1.8	-0.2	-3.1	-0.1	1.1
Hearing difficulty/problems: Yes	0.8	1.3	5.4	-0.8	0.4	-1.5	-0.5	-0.2	-0.2	0.2	2.0	-1.0	0.4	2.3
Relative age of first facial hair	0.7	1.5	5.5	-1.0	0.9	0.8	0.1	2.3	0.5	1.8	-1.4	-1.6	-0.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	6.2	-2.5	0.1	-0.4	-1.1	0.2	0.0	-0.1	0.3	0.4	-1.0	-0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.6	0.8	-1.5	-0.6	-0.5	0.7	1.3	-0.6	0.0	1.5	-1.9	-1.7
Ever had hysterectomy (womb removed)	0.9	1.0	3.7	-0.4	-0.3	0.2	-1.6	1.9	0.4	1.2	-0.4	-0.7	-1.2	0.6
Systolic blood pressure, automated reading	0.4	1.3	4.2	1.0	-2.0	0.6	0.2	-1.3	0.2	-1.5	-1.3	1.6	0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	8.2	0.3	2.0	-0.4	-1.9	0.6	-2.1	-0.6	1.8	-1.3	2.1	2.9
Angina	0.4	0.6	3.3	-0.5	-1.4	-0.3	0.0	1.8	0.3	0.1	0.1	0.6	0.1	-0.0
Medication for hormone replacement therapy	0.5	0.6	3.4	0.0	-0.3	0.1	0.5	1.8	0.4	0.4	-1.1	-0.1	-0.6	-0.8
Vitamin and mineral supplements	0.3	0.4	0.9	-0.1	-0.6	-0.0	0.7	-0.4	-0.9	-0.4	-0.2	0.7	-1.0	-0.8
Supplements: Zinc	1.3	1.4	6.1	-0.5	-0.9	-1.6	-1.5	-0.4	0.1	1.4	0.6	0.0	-2.5	-1.1
Medication: Co-codamol	2.6	3.0	8.5	2.5	-0.9	1.3	-0.1	-2.1	-0.9	-2.9	-1.1	-0.0	2.5	1.7
Medication: Metformin	0.8	1.1	3.8	0.3	-0.8	-0.1	-1.3	0.7	-1.9	-0.5	1.1	-0.4	0.6	2.0
Diabetes (father)	0.6	0.7	3.6	-0.1	0.4	1.9	-0.7	-0.1	-0.3	0.3	-0.4	-1.4	0.3	1.1
Diabetes (mother)	0.6	0.7	2.0	-1.4	-0.3	-1.3	-0.2	0.4	0.8	-0.8	0.0	1.3	-0.9	-0.4
Severe depression (siblings)	0.9	1.0	3.0	-1.3	1.7	-0.1	-0.2	0.9	-0.8	0.3	1.6	0.4	0.2	1.5
Pack years adult smoking proportion	0.7	1.1	2.9	1.6	-1.6	1.0	0.0	-1.7	1.1	0.1	-1.1	0.0	0.5	-0.5
Impedance of leg (right)	0.2	1.0	6.2	0.1	-1.0	-0.3	2.5	-1.1	-0.8	0.8	-0.3	-0.1	0.1	-1.1
Leg fat-free mass (left)	0.2	1.2	4.3	-0.6	0.4	-0.3	-2.1	0.4	0.3	-1.9	1.2	0.5	0.5	1.7
Trunk fat percentage	0.4	1.4	4.3	-0.1	0.1	0.1	-1.4	-1.7	-1.6	-0.6	1.6	-0.9	-0.3	2.1
Hand grip strength (right)	0.2	0.6	1.9	0.5	-0.4	-1.1	-0.4	-0.7	-0.4	1.2	0.6	-1.4	-0.7	-0.1
Townsend deprivation index at recruitment	0.7	1.0	2.8	0.2	-0.2	-0.2	-1.0	0.2	-1.6	0.6	1.7	-1.1	-0.9	1.3
Current tobacco smoking	0.2	0.4	1.0	-0.1	-0.7	0.3	0.9	-0.0	-0.7	-0.5	0.9	-0.2	0.6	1.0
Average weekly fortified wine intake	0.6	0.7	2.2	-0.0	0.7	-1.5	-0.0	-0.1	0.8	-0.8	0.7	1.4	-1.1	0.1
Maternal smoking around birth	1.3	1.9	6.1	-0.6	2.5	0.0	-0.8	0.3	-1.7	0.5	1.8	-1.0	0.4	2.5
Fed-up feelings	1.1	1.9	6.9	-0.4	1.2	2.6	-2.2	0.2	-0.2	0.9	-0.5	-2.5	-0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	-0.8	0.4	1.8	-1.2	1.7	0.2	0.6	-0.8	-0.9	0.4	0.4
Relative age voice broke	0.3	0.5	2.0	-0.1	1.2	0.1	0.6	1.4	0.5	-0.2	0.2	-0.1	1.1	0.2
Taking other prescription medications	0.3	0.4	1.5	-1.2	0.1	-0.6	-0.7	0.2	-0.0	0.4	-0.2	0.7	-0.7	-1.0
Age when periods started (menarche)	1.0	2.4	5.6	-0.3	-1.3	-2.1	2.3	-0.6	2.0	0.4	0.8	1.8	-0.6	-2.4
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	6.2	2.1	-2.0	1.9	0.9	-0.4	2.5	-0.6	-1.3	0.5	-0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.4	-0.3	-0.7	-0.4	-0.6	-0.2	-1.0	-0.7	-0.3	1.6	-1.1	0.5
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	6.0	-0.2	-2.4	2.2	0.2	-0.8	1.3	-1.4	-2.4	1.8	0.6	-1.1
Qualifications: CSEs or equivalent	2.2	2.8	7.2	-2.6	2.7	-0.8	-0.2	0.1	-0.2	1.3	2.4	-1.3	0.8	2.5
Serious illness, injury or assault to yourself	0.7	0.9	4.8	-2.2	0.5	0.1	0.4	1.5	0.9	0.2	0.0	0.5	-0.8	-0.7
High blood pressure	0.2	0.6	3.9	-0.6	0.5	-0.1	-0.5	0.8	2.0	0.1	0.7	0.5	0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.4	0.0	1.6	-1.4	-0.7	1.0	0.6	-0.3	0.1	-0.1	-0.1	-1.4
Multivitamins +/- minerals	0.6	0.8	1.9	0.1	1.4	-0.3	-0.4	1.0	0.9	1.1	0.2	-1.4	1.1	-0.1
Stomach or abdominal pain in last month	0.7	0.8	1.9	1.1	1.0	-0.2	0.9	-0.8	1.0	0.0	0.7	-1.2	1.4	-0.3
Supplements: Glucosamine	0.6	0.7	2.2	-1.3	-0.2	-0.8	-1.5	0.7	0.7	0.3	0.2	0.6	-1.2	-0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	6.2	-2.5	0.4	-0.8	1.3	0.4	1.3	0.7	0.1	-0.3	0.5	-1.1
Medication: Atenolol	1.3	1.7	8.0	-0.6	-0.1	2.8	-1.0	1.1	1.3	0.8	-1.8	-0.7	0.8	1.1
Medication: Levothyroxine sodium	0.5	0.8	3.0	-0.5	0.2	-1.2	-1.1	1.7	-1.0	-0.4	1.1	0.2	-0.0	-0.2
Sitting height	0.2	1.3	3.5	-1.5	-0.3	-1.5	0.1	-0.6	-0.1	-1.9	1.9	1.6	-0.3	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	-0.7	0.8	-0.7	-0.2	0.9	-0.8	-0.4	1.3	-0.0	1.1	0.6
High blood pressure (mother)	0.4	0.5	1.7	-1.0	0.1	1.3	-0.6	-0.9	0.1	0.4	0.2	-0.6	0.2	1.3
Body mass index (BMI)	0.5	2.3	8.8	0.3	1.2	1.0	-2.7	-0.7	-1.1	-1.8	1.3	-0.4	-0.1	3.0
Impedance of leg (left)	0.2	1.0	4.9	-0.3	-0.7	-0.4	2.2	-0.4	-0.9	1.7	-0.1	-0.7	-0.2	-1.0
Leg predicted mass (left)	0.3	1.4	4.8	-0.5	0.4	-0.3	-2.2	0.3	0.3	-2.0	1.3	0.5	0.5	1.8
Trunk fat mass	0.3	1.4	5.0	-0.2	0.1	-0.0	-1.6	-1.3	-1.1	-1.3	1.8	-0.2	-0.1	2.2
Waist circumference	0.4	1.5	6.2	0.1	0.6	0.3	-1.6	-0.3	-0.7	-2.5	1.5	0.9	0.2	1.9
Number of incorrect matches in round	0.6	1.1	6.7	-0.9	-0.4	0.3	-1.1	1.1	-1.0	-0.1	-0.7	0.1	-2.6	0.1
Past tobacco smoking	0.3	0.5	2.9	1.7	0.1	0.1	0.9	-0.7	0.4	-0.3	0.0	0.5	0.5	-0.8
Alcohol usually taken with meals	0.7	1.1	2.2	-0.9	-1.4	-0.6	1.5	0.3	0.1	0.6	-1.5	1.2	-1.3	-0.9
Nervous feelings	1.5	2.8	10.7	-2.2	0.6	0.3	0.5	-0.9	1.3	3.3	0.6	-3.3	-0.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.9	-1.7	1.3	1.1	0.1	0.8	0.6	1.7	-0.9	-1.1	-0.7	-1.5
Hearing difficulty/problems with background noise	0.5	0.7	2.4	0.6	-1.4	-1.5	0.1	0.2	0.7	1.3	0.8	-0.7	0.1	-0.1
Hair/balding pattern: Pattern 2	0.7	0.9	3.8	-0.8	0.9	0.6	-1.9	1.0	-0.5	0.5	1.1	-0.7	-0.2	0.8
Had menopause	0.5	0.7	4.8	-0.3	-0.3	-0.3	0.5	-0.2	0.3	-1.2	-0.5	2.2	0.3	-0.2
Had other major operations	0.9	1.0	3.1	0.5	-0.4	0.8	-0.5	-1.8	-0.1	-1.5	-0.8	1.7	-1.1	-0.1
Forced vital capacity (FVC)	0.4	1.6	3.4	-1.2	1.7	-1.4	0.7	1.4	-0.2	1.8	1.8	-1.4	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	-0.3	-0.7	-0.4	-0.3	-0.3	-0.6	-0.2	-1.1	1.2	-0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.8	-0.8	0.2	0.5	-1.6	-0.1	-0.2	1.1	-0.2	-0.7	-1.7	-0.3
Qualifications: None of the above	0.0	0.1	0.3	0.1	0.3	0.5	-0.1	0.3	0.4	-0.4	0.1	-0.0	0.2	0.6
Financial difficulties in last 2 years	1.1	1.5	2.8	1.2	1.0	1.5	-0.4	1.1	0.4	1.6	0.8	-1.7	1.1	1.6
Mouth/teeth dental problems	1.3	2.0	7.2	-0.0	1.4	-2.2	-0.3	0.7	-1.5	2.7	0.5	-2.3	-0.4	0.2
Heart attack	1.1	1.4	5.9	-0.9	0.9	0.6	-1.1	2.4	-1.1	0.6	0.3	-1.4	-0.1	1.8
Allergy	0.4	1.0	5.6	0.7	-0.9	2.4	-0.1	-0.9	0.0	-0.4	-0.9	0.2	0.4	1.4
Pain all over the body in last month	0.7	0.7	1.8	0.3	0.2	1.2	0.4	0.0	0.1	-1.3	-1.3	1.1	0.9	-1.0
Diabetes (self-reported)	1.2	1.9	6.0	0.9	-0.2	-0.2	-1.8	0.5	-2.1	-1.9	1.0	0.6	1.2	2.5
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	13.0	-1.5	3.6	-2.4	-0.9	-1.9	-0.3	0.1	1.2	-1.3	0.1	-0.0
Medication: Ramipril	0.6	0.8	2.2	-0.8	0.7	-0.3	-0.7	0.9	1.5	-0.8	0.9	0.2	1.4	0.8
Medication: Simvastatin	0.8	1.1	3.8	0.6	-1.3	1.1	-1.1	-0.7	-0.7	-1.9	-0.9	0.7	0.9	1.2
Fluid intelligence score	1.1	2.3	10.2	1.5	-1.4	-0.1	0.2	0.5	1.7	2.5	-0.6	-0.4	-1.1	-3.2
Illnesses of siblings	1.5	2.0	6.1	1.0	-2.5	-0.3	1.9	-0.5	-0.2	-0.8	-1.8	1.4	-0.7	-2.2
Neuroticism score	1.2	2.5	10.9	-0.2	1.5	2.4	-1.2	-0.5	0.7	2.4	0.4	-3.3	-1.2	0.2
Weight	0.4	1.7	6.1	-0.4	0.8	0.2	-2.2	-0.3	-0.6	-1.9	1.9	0.2	-0.0	2.5
Impedance of arm (right)	0.3	1.5	3.3	0.7	-1.3	-0.9	1.7	-1.0	-0.4	1.8	0.2	-1.4	-0.9	-1.8
Arm fat percentage (right)	0.5	1.9	6.2	0.6	0.7	0.5	-2.2	-1.4	-1.5	-1.3	1.3	-1.0	-0.1	2.5
Trunk fat-free mass	0.2	1.3	5.5	-0.5	0.3	-0.3	-1.4	0.4	0.8	-2.4	1.1	1.1	0.8	1.7
Hip circumference	0.4	1.7	6.0	0.2	0.6	0.9	-2.2	-1.1	-0.5	-1.9	1.2	0.2	0.6	2.5
Time employed in main current job	0.6	0.7	4.2	0.4	0.1	0.4	-0.2	0.5	-0.2	-0.6	-1.3	0.1	2.1	0.3
Alcohol intake versus 10 years previously	0.4	0.6	1.7	-0.8	0.5	0.8	-1.0	1.3	-0.1	-1.1	-0.9	0.6	0.5	-0.2
Father’s age at death	0.5	0.7	3.7	0.2	0.1	0.3	0.7	-0.2	0.6	-1.2	-1.9	0.7	0.6	-0.7
Worrier / anxious feelings	1.7	3.2	13.2	-0.7	0.9	3.6	0.9	-0.9	1.4	2.1	-1.9	-2.6	-0.8	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	5.7	0.6	0.6	-0.2	-0.9	-0.1	0.2	1.6	1.3	-2.4	0.4	-0.3
Falls in the last year	0.9	1.2	4.1	-2.0	1.3	0.4	0.9	0.5	1.6	-0.3	0.1	1.5	0.4	-0.9
Hair/balding pattern: Pattern 3	1.3	1.9	5.6	-1.2	2.4	1.3	1.7	-2.0	0.2	-0.1	-0.9	-0.2	2.1	0.2
Number of live births	0.7	1.0	3.4	1.7	0.2	0.3	0.7	-1.9	0.1	-1.2	-0.2	0.4	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.8	2.1	-1.0	1.4	-1.4	-0.2	0.2	-0.6	0.9	1.2	-1.1	-0.1	0.5
Pulse rate	0.8	1.3	9.0	0.5	0.4	0.2	0.9	0.5	0.8	-1.2	0.3	0.2	3.0	1.3
Happiness	0.4	0.5	2.0	-0.5	-0.3	-1.0	-0.2	0.2	0.2	0.7	1.4	-0.4	-1.2	-0.4
Noisy workplace	0.4	0.4	2.3	-1.5	0.5	0.1	-0.2	0.8	0.5	0.0	0.6	0.2	0.4	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	1.3	-1.5	-0.6	1.4	0.0	0.2	0.4	-0.6	0.3	0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	5.1	-1.2	0.3	-0.5	0.1	-0.4	0.3	2.3	1.4	-1.7	-0.5	-0.3
Mouth/teeth dental problems: Dentures	0.7	1.2	3.8	0.8	-2.0	0.7	-0.7	-0.1	0.9	-1.8	0.0	1.4	-0.9	-1.0
Asthma	0.4	0.7	1.9	-1.0	0.5	-0.9	-0.9	0.3	-0.6	1.4	0.1	-1.3	-1.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	5.8	-0.7	0.5	2.4	-0.6	0.2	-1.2	-0.3	-0.7	-1.2	1.6	1.5
Medication: Cholesterol lowering	0.2	0.4	1.9	0.1	-0.3	1.4	-0.8	0.2	-0.2	-0.8	-0.3	-0.0	0.3	0.7
Depression (self-reported)	1.3	1.5	3.5	1.6	-1.9	-0.1	-0.5	-1.1	1.5	0.5	1.1	0.7	-1.9	-1.2
Medication: Lansoprazole	0.3	0.3	1.4	0.7	-1.2	0.0	-0.4	-0.0	0.6	0.1	-1.0	-0.4	-0.2	0.2
Prospective memory result	0.3	0.3	1.8	0.3	0.2	-0.2	-0.6	0.9	0.5	0.1	0.2	-0.3	0.3	1.3
Lung cancer (father)	1.6	1.8	3.9	-0.8	0.8	1.0	-1.0	1.9	-1.2	1.8	-0.4	-2.0	-1.5	1.5
Illnesses of mother	1.1	1.4	4.0	1.5	-0.7	-1.4	1.2	-0.2	0.8	-1.0	-0.9	1.6	0.4	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	2.2	-0.0	0.6	-1.5	-0.1	0.6	0.6	0.7	1.0	-0.3	-0.3	0.1
Pulse wave Arterial Stiffness index	0.9	1.0	3.1	-0.5	0.5	1.4	-0.9	0.1	0.1	-1.6	-0.3	1.8	1.2	0.9
Impedance of arm (left)	0.5	2.1	6.1	0.3	-1.2	-0.8	2.4	-1.1	-0.2	2.5	-0.2	-1.5	-0.6	-2.3
Arm fat mass (right)	0.4	1.8	7.5	0.2	0.6	0.6	-2.4	-1.0	-0.9	-1.7	1.1	-0.5	0.1	2.7
Trunk predicted mass	0.2	1.3	5.4	-0.5	0.3	-0.2	-1.4	0.3	0.8	-2.3	1.0	1.0	0.8	1.7
Standing height	0.1	1.2	3.5	-1.4	-1.0	-1.9	0.7	0.5	1.0	-0.5	1.7	1.1	0.0	-0.7
Length of working week for main job	1.0	1.1	4.0	-0.1	-0.4	-2.0	-0.1	-0.5	-1.9	-1.6	1.1	0.3	0.1	0.4
Exposure to tobacco smoke at home	0.9	1.0	3.1	1.2	-0.9	1.5	0.0	-1.8	-0.5	-1.0	0.3	1.0	-0.0	0.7
Breastfed as a baby	1.2	1.5	5.7	-0.5	-0.6	-1.0	1.5	0.6	1.6	-1.0	1.1	2.4	0.7	-1.1
Tense / ‘highly strung’	1.2	2.0	6.9	-0.2	1.6	0.4	-0.2	-0.0	1.9	2.6	0.6	-1.9	-1.8	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	6.2	0.1	-0.4	1.9	-0.6	-2.5	0.2	0.2	-1.9	-2.1	0.7	0.2
Hair/balding pattern: Pattern 4	1.1	2.5	5.1	1.6	-2.3	-2.2	1.7	0.9	0.2	-1.7	1.8	1.6	1.3	1.1
Birth weight of first child	0.5	0.9	4.1	0.2	1.2	-0.9	-0.4	0.9	2.0	0.4	1.6	-0.1	-0.1	-0.3
Peak expiratory flow (PEF)	0.9	2.2	8.1	-0.6	1.3	-2.9	-1.5	-1.5	-1.2	1.0	1.7	-1.6	-1.0	0.5
Pulse wave reflection index	1.1	1.4	6.9	-2.6	0.7	1.4	-1.1	0.8	0.3	-0.1	-1.2	1.4	-0.2	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	6.3	-0.6	0.6	2.5	-0.3	0.3	0.3	1.5	-0.6	-1.4	-0.8	0.0
Loud music exposure frequency	1.2	1.3	4.5	-0.2	1.9	-0.1	-2.1	0.8	-0.0	0.9	1.0	-1.6	-0.6	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	0.4	-0.5	0.3	0.7	0.2	0.8	0.9	-1.2	-0.9	-0.2	-1.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.9	0.5	0.3	1.3	1.0	-1.4	0.7	-1.2	0.7	0.6	2.2	1.2
Blood clot in the leg (DVT)	0.6	0.7	3.7	-0.3	-0.5	-1.9	0.4	0.2	1.0	-0.4	1.2	0.7	0.9	0.0
Medication: Paracetamol	0.4	0.6	1.6	-1.3	0.9	0.1	1.2	-0.2	0.2	-0.7	-0.3	0.6	1.3	-0.6
Headache pain in last month	0.2	0.3	1.2	-0.0	1.1	0.9	-0.2	-0.5	0.6	-0.4	-0.2	-0.8	0.3	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.5	-0.1	1.2	-0.2	0.3	0.5	-1.0	0.2	0.0	-0.1	-0.4	0.2
Glaucoma (self-reported)	0.9	1.0	3.7	1.6	0.8	-0.0	-0.8	-0.8	1.9	-0.8	-0.7	0.5	0.4	-1.4
Gout (self-reported)	0.7	1.0	3.5	1.9	-0.5	0.9	0.4	0.9	0.6	0.7	-0.7	0.1	-0.6	-1.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	4.0	-0.2	-0.1	-2.0	-0.4	0.9	-0.9	-0.8	1.2	1.5	-0.6	-0.8
Medication: Amlodipine	1.7	2.3	7.7	2.2	-0.9	1.8	-0.7	1.4	-0.3	1.8	-1.2	-2.8	0.6	1.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	6.1	-2.5	0.0	-2.4	-0.6	-0.2	-0.7	0.8	0.4	0.1	-2.2	-1.1
Birth weight	0.7	1.5	6.1	-0.6	2.5	0.4	0.5	-0.2	0.3	1.5	1.7	-1.6	-0.4	1.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.1	-1.4	0.2	0.2	0.8	-0.9	0.7	1.4	0.2	-0.6	0.0	-0.3
High blood pressure (siblings)	0.8	1.2	4.7	-0.6	1.5	0.6	-1.2	-0.4	-0.7	0.1	1.2	-1.2	0.6	2.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.4	-0.3	0.3	-1.1	0.7	1.2	0.9	1.6	1.4	-0.4	-0.3	0.1
Body fat percentage	0.5	1.9	7.2	0.1	0.4	0.6	-1.9	-1.4	-1.7	-1.2	1.6	-0.6	0.0	2.7
Leg fat percentage (right)	0.6	2.1	7.9	0.7	0.4	0.9	-2.2	-1.0	-1.7	-1.9	1.2	-0.1	-0.1	2.8
Arm fat-free mass (right)	0.2	1.1	2.9	-1.0	0.6	-0.3	-1.5	0.6	0.3	-1.7	1.0	0.7	0.8	1.7
Exposure to tobacco smoke outside home	1.0	1.4	4.8	1.4	-1.4	1.2	-0.1	-2.2	1.5	-0.2	0.4	-0.1	1.3	0.9
Comparative body size at age 10	0.6	1.5	6.3	1.2	0.6	2.3	-0.5	1.2	1.3	-0.0	-2.5	-0.3	-0.2	-0.1
Number of full brothers	1.9	2.3	13.6	0.7	-0.2	-1.4	-1.5	-1.4	1.5	0.3	3.7	0.0	-1.6	0.7
Worry too long after embarrassment	1.1	1.9	6.9	1.4	0.0	-0.3	-0.6	-2.6	1.0	1.3	1.1	-1.5	-2.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	3.1	0.6	-0.5	1.5	0.1	-1.0	1.1	0.2	-0.7	-0.7	-1.8	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.7	-0.5	-0.4	-0.4	0.5	-1.3	-0.1	0.6	-0.2	-0.8	0.3	-0.9
Number of children fathered	0.5	0.6	2.3	1.5	-1.1	0.8	-0.7	-0.3	0.3	-0.4	0.5	-0.5	0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.3	-0.3	0.3	0.6	1.1	-0.8	0.1	0.8	-1.4	-0.9	0.4	-1.8
Age at first live birth	0.2	0.4	1.4	0.0	-0.1	-1.1	-0.6	0.2	-0.5	0.4	1.2	-0.6	-0.3	0.1
Pulse wave peak to peak time	0.9	1.1	2.9	0.4	-0.3	-1.7	0.8	0.1	-0.2	1.5	0.6	-1.6	-1.4	-1.0
Health satisfaction	0.6	0.7	2.6	-0.9	-1.6	0.9	0.8	-0.3	1.1	-0.8	-0.5	1.0	0.1	-0.3
Shortness of breath walking on level ground	1.3	1.5	5.5	-1.1	-1.2	0.4	0.1	-0.9	2.4	-1.3	0.6	2.2	0.8	0.2
Qualifications: College or University degree	0.2	0.5	2.3	0.7	-0.4	-0.9	-0.3	-0.4	-1.1	0.1	0.1	0.4	-1.5	-0.2
Eye problems/disorders: None of the above	0.7	0.8	3.4	0.3	0.2	0.4	-0.3	0.9	-0.4	1.2	-0.6	-1.4	-1.8	-0.2
Mouth/teeth dental problems: Loose teeth	2.1	2.4	7.0	0.7	-1.3	-1.3	2.2	-1.4	1.2	-2.2	0.1	2.6	0.2	-1.6
Emphysema/chronic bronchitis	0.5	0.6	2.5	-0.9	-0.8	-1.2	-0.6	-0.0	-1.6	-0.7	-0.4	0.1	-0.5	-0.2
Medication for pain relief, constipation, heartburn	1.1	1.8	3.8	1.9	-0.7	-1.5	-1.3	-1.4	0.2	1.1	1.8	-1.5	-1.7	0.3
Neck or shoulder pain in last month	0.9	1.3	4.7	-2.2	0.4	-0.1	1.4	-0.7	2.0	-0.3	-0.4	1.4	0.8	-0.8
Medication: Blood pressure	0.3	0.6	2.6	0.4	-1.6	0.0	0.0	-0.9	1.4	0.2	-0.2	-0.2	0.4	-0.8
Angina (self-reported)	0.5	0.6	4.3	-0.5	-1.3	-0.2	-0.1	2.1	0.3	0.2	0.0	0.6	0.1	0.1
Migraine (self-reported)	0.8	1.0	4.5	-0.6	-0.9	0.0	-0.5	-2.1	0.7	-0.3	-1.8	-0.3	-0.8	-0.6
Medication: Ibuprofen	0.9	1.1	6.3	-1.4	0.1	2.5	-0.1	-0.3	-0.4	-0.3	-0.6	-0.6	1.3	1.1
Medication: Allopurinol	0.4	0.5	1.8	1.2	-0.2	0.6	-0.6	0.2	-0.3	0.5	-0.5	-0.4	-1.3	-0.8
Medication: Omeprazole	0.8	0.9	3.4	-1.8	1.4	0.2	0.6	1.1	0.3	1.2	-0.6	-0.6	0.1	0.7
Medication: Seretide 50 evohaler	0.7	0.8	3.0	-1.0	-0.6	-1.7	-0.8	-0.1	-1.3	0.1	0.8	0.2	-1.1	-0.1
Mean time to correctly identify matches	0.5	1.0	3.9	0.4	0.1	-1.0	0.7	-0.4	-0.5	-1.4	0.9	2.0	-1.0	-1.1
Heart disease (mother)	0.7	0.9	4.4	0.3	-0.6	1.2	0.2	2.1	1.1	0.2	1.1	0.9	0.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.9	1.0	-0.4	-0.4	1.2	-0.7	0.1	-0.3	-1.3	0.5	-0.1	-1.4
Whole body fat mass	0.4	1.7	6.5	-0.0	0.2	0.5	-2.2	-0.9	-1.2	-1.8	1.4	-0.0	0.0	2.6
Leg fat mass (right)	0.6	2.1	7.5	0.3	0.5	0.7	-2.5	-0.8	-1.2	-2.2	1.4	0.2	0.1	2.7
Arm predicted mass (right)	0.3	1.4	4.0	-1.0	0.6	-0.3	-1.5	0.7	0.3	-1.7	1.4	0.7	1.1	2.0
Pulse rate, automated reading	0.3	1.0	3.0	0.7	1.1	-1.4	-0.2	-0.3	-0.3	-1.7	1.4	0.4	1.3	0.6
Alcohol intake frequency.	0.1	0.3	1.0	0.7	0.0	-0.1	-1.0	-0.2	-0.6	0.1	-0.2	-0.9	-0.7	0.2
Comparative height size at age 10	0.1	0.5	1.5	-0.0	-1.0	-1.2	0.0	-0.3	-0.1	-0.3	0.5	1.1	-0.7	-1.1
Number of full sisters	0.3	0.4	1.2	-0.2	-0.5	-0.7	1.1	-0.0	0.4	0.6	1.0	-0.3	0.7	0.0
Suffer from ‘nerves’	0.4	0.6	2.4	-0.4	0.4	0.1	-0.1	-0.2	1.4	1.0	1.6	-0.5	-0.8	0.3
Overall health rating	0.3	0.7	2.2	-0.5	-0.3	-1.1	-0.4	-1.0	1.0	0.5	1.5	-0.6	-0.4	-0.7
Chest pain or discomfort	0.3	0.5	2.2	-1.5	0.2	-1.0	-0.0	0.4	-0.3	0.8	0.7	-0.8	-0.1	-0.3
Had major operations	0.9	1.0	4.1	-2.0	0.8	-0.9	0.3	1.9	-1.1	0.1	-0.8	0.4	0.6	0.2
Age at last live birth	0.3	0.4	1.4	0.2	0.2	-0.3	-0.8	-0.4	-1.2	-0.5	1.2	-0.1	-0.3	0.1
Family relationship satisfaction	0.5	0.7	2.8	0.1	-0.4	-0.7	-1.7	0.5	-0.4	-0.6	1.1	0.7	-1.1	-0.1
Leg pain on walking	0.6	0.7	4.0	-0.1	-0.6	2.0	-1.1	0.6	0.4	-0.5	-0.9	0.1	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.6	1.3	0.1	-1.2	-1.9	0.5	-1.8	0.5	0.7	-1.9	-1.1	1.4
Commuting to job workplace: Car/motor vehicle	2.0	2.3	7.1	2.4	-0.9	2.7	-1.3	-1.4	0.6	-0.9	-1.9	-0.8	1.2	0.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.6	0.4	-0.4	0.7	0.9	-0.2	0.2	-0.1	-1.9	0.7	1.0	-0.3
Medication: Aspirin	0.7	0.9	4.1	-0.4	-1.1	1.3	-0.5	2.0	-0.7	0.0	-1.4	0.3	-0.3	0.5
Supplements: Vitamin C	0.6	0.7	2.1	-0.4	-0.4	0.1	-1.2	-0.2	1.3	-0.2	-0.8	1.5	-1.3	-0.5
Knee pain experienced in last month	0.7	1.0	4.0	0.7	-1.8	0.3	0.2	-0.8	0.1	-2.0	-0.6	1.3	0.7	-0.4
Hypertension (Self-reported)	0.1	0.4	2.3	-0.4	0.6	0.1	-0.9	0.4	1.5	0.0	0.7	0.1	0.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.2	-2.0	0.9	0.9	0.7	-0.2	-0.4	1.2	-0.9	-0.1	-1.3	-0.0
Illnesses of father: Heart disease	0.2	0.3	1.0	0.3	-0.2	1.0	-0.5	-0.7	-0.5	0.9	-0.4	-0.1	-0.5	-0.4
Illnesses of siblings: Diabetes	0.7	0.9	2.9	-0.6	-0.6	0.0	-1.6	0.6	1.0	-0.9	0.7	0.7	1.7	0.7
Smoking status: Previous	0.2	0.3	0.7	-0.6	-0.3	-0.8	-0.9	0.1	-0.3	0.3	-0.3	-0.2	-0.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	-0.9	-0.6	0.9	0.4	1.6	1.4	0.7	-0.7	0.0	0.7	-0.3
Whole body fat-free mass	0.2	1.4	4.3	-0.7	0.4	-0.3	-1.8	0.5	0.6	-2.1	1.2	0.7	0.7	1.9
Leg fat-free mass (right)	0.2	1.2	5.0	-0.9	0.5	-0.5	-2.2	0.5	0.2	-1.3	1.3	0.2	0.3	1.7
Arm fat percentage (left)	0.4	1.7	6.2	0.5	0.8	0.8	-1.9	-1.6	-1.4	-1.0	1.1	-1.1	0.3	2.5
Average weekly red wine intake	1.6	2.4	9.6	-0.3	-1.3	-0.1	1.8	0.8	1.4	-1.3	-2.0	3.1	0.6	-1.6
Handedness (chirality/laterality): Left-handed	2.4	2.9	7.8	-1.1	0.2	0.9	2.0	1.7	2.8	-0.2	-1.8	1.8	1.3	-2.7
Mood swings	0.4	0.8	2.6	-0.3	1.2	0.7	-1.4	-0.3	-0.9	0.2	-0.3	-0.9	-1.6	-0.1
Loneliness, isolation	1.2	1.7	9.2	-0.6	1.3	1.0	0.3	1.1	0.7	2.1	0.2	-3.0	0.2	0.0
Long-standing illness, disability or infirmity	1.0	1.5	13.2	-3.6	-0.2	-1.0	0.0	-1.1	0.6	0.5	0.5	-0.6	0.1	-0.3
Ever had bowel cancer screening	0.5	0.6	3.2	0.1	0.3	-1.0	0.5	1.8	-0.4	0.2	0.5	0.0	-1.1	-0.1
Diabetes diagnosed by doctor	1.3	2.1	7.4	0.1	-0.2	0.4	-1.9	0.2	-2.0	-2.0	1.0	0.7	1.4	2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	-1.4	-1.1	0.9	0.6	0.3	-0.3	0.9	-1.1	-0.8	-1.2	-0.7
Friendships satisfaction	0.3	0.4	1.4	0.2	-0.8	-0.5	0.6	0.9	-0.2	-0.3	0.2	1.2	0.1	-0.6
Qualifications: nursing, teaching	0.4	0.6	2.8	-0.8	0.9	0.4	-0.8	-0.5	-0.3	0.4	0.8	0.3	-1.7	0.4
Commuting to job workplace: Walk	2.0	2.2	5.5	-0.5	1.9	-2.3	0.7	2.1	0.1	1.6	1.6	-0.5	-2.2	-0.3
Eye problems/disorders: Cataract	0.6	0.7	1.6	-0.7	-0.5	-0.8	1.0	-1.3	0.0	-0.8	1.0	1.1	0.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.7	0.0	0.1	-0.2	-0.7	-0.3	1.3	-0.9	-0.3	0.6	0.1	-0.4
Medication for cholesterol	0.6	1.0	3.3	0.4	1.4	-0.2	0.6	-1.8	-1.0	0.6	1.4	-1.1	0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	5.8	1.5	-1.8	0.9	0.2	1.5	0.8	-1.0	-1.4	2.4	-0.9	-2.0
Back pain experienced in last month	0.8	1.2	5.4	0.8	-1.1	-1.3	-1.0	0.3	1.0	-2.3	-0.1	1.0	-0.5	-0.8
Mineral and other dietary supplements	0.5	0.7	3.2	-0.1	-0.5	1.3	1.8	0.1	-0.4	-0.5	-0.7	-0.1	1.2	0.1
Breast cancer (self-reported)	1.0	1.2	5.5	-1.0	0.3	0.1	0.2	0.8	-0.1	2.4	0.1	-2.1	0.9	0.3
Asthma (self-reported)	0.3	0.6	1.9	-0.7	-0.0	-1.1	-0.7	0.7	-0.3	1.4	0.4	-1.0	-0.9	-0.5
Osteoporosis (self-reported)	1.3	1.7	6.2	-2.5	2.4	-0.7	0.7	1.3	0.4	0.9	1.0	0.6	-0.6	-1.0
Osteoarthritis (self-reported)	0.6	0.8	2.7	-0.4	-1.1	-0.7	1.6	0.3	1.2	0.2	0.0	0.5	1.6	-0.6
Medication: Aspirin	0.7	1.0	4.0	-0.8	-1.0	1.0	-0.8	2.0	-1.0	-0.2	-1.2	0.5	-0.6	0.6
Medication: Gliclazide	0.6	0.7	3.2	1.8	0.7	0.7	-1.2	0.5	0.1	-0.1	0.3	-0.4	0.1	1.3
Illnesses of father: None of the above (group 1)	2.2	2.7	9.9	-0.7	1.1	-3.1	0.4	1.0	0.3	2.3	1.6	-1.3	-2.6	-0.8
Smoking status: Current	0.3	0.5	1.4	-0.4	-0.4	1.1	0.8	0.2	-0.7	-0.1	0.7	-0.5	0.5	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.2	1.0	-0.2	1.0	0.1	1.5	0.7	0.8	-0.9	0.1	-0.3	0.0
Whole body water mass	0.2	1.4	4.2	-0.7	0.5	-0.3	-1.8	0.5	0.5	-2.1	1.3	0.7	0.7	2.0
Leg predicted mass (right)	0.2	1.2	5.2	-0.8	0.5	-0.5	-2.3	0.5	0.2	-1.4	1.3	0.2	0.3	1.8
Arm fat mass (left)	0.4	1.6	6.5	0.2	0.6	0.7	-2.2	-0.9	-0.8	-1.6	1.2	-0.4	0.2	2.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-1.2	0.6	-0.8	-1.1	-0.3	1.1	0.2	0.8	0.2	0.1	0.2
Average weekly champagne plus white wine intake	0.6	0.8	5.8	-0.9	-0.2	0.7	0.1	0.6	-2.4	-0.3	-0.3	-0.3	0.8	0.6
Miserableness	1.7	2.9	10.3	-1.8	1.5	1.8	-2.1	0.4	-0.9	2.2	0.5	-3.2	-0.1	1.7
Guilty feelings	1.4	2.1	11.6	-0.2	2.0	0.7	-0.2	-1.1	-1.0	1.7	0.5	-3.4	0.6	1.2
Wears glasses or contact lenses	0.6	0.7	3.1	-1.1	0.7	-0.8	-0.2	1.8	-1.0	0.2	0.4	-0.4	-0.3	0.4
Ever taken oral contraceptive pill	1.0	1.1	3.8	1.0	-2.0	0.0	-1.0	-0.3	-1.4	0.2	-1.2	-1.1	-0.9	-0.9
Hearing aid user	1.2	1.4	4.1	0.2	-0.2	-1.6	-1.1	0.7	-0.9	1.2	2.0	-0.9	-0.9	1.7
Mother’s age at death	0.6	0.7	3.1	0.3	1.1	0.2	-0.2	-0.6	0.5	-1.1	-0.8	-0.7	1.8	0.6
Financial situation satisfaction	0.5	0.6	2.7	0.0	-0.2	1.6	0.5	0.3	0.7	0.5	-0.3	-0.9	1.1	0.6
Tinnitus: Yes, now most or all of the time	1.0	1.1	5.0	-1.7	0.8	0.3	-0.2	2.2	0.7	1.5	0.3	-0.7	0.8	-0.2
Commuting to job workplace: Public transport	0.7	0.8	4.3	-0.3	-0.8	0.4	0.8	0.7	0.8	-0.7	-0.5	2.1	-0.6	-1.0
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	1.6	0.2	0.5	-0.6	-0.8	1.6	-1.0	-0.9	0.8	0.9	-0.8
Medication: Blood pressure	0.6	1.2	4.8	0.1	-0.6	1.3	-1.9	2.2	0.4	-0.0	-1.2	0.2	-1.1	0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.2	-0.4	-0.8	0.8	0.5	1.6	1.1	-1.2	0.0	0.7	2.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.4	0.7	-0.3	-0.8	0.4	0.6	-0.0	0.3	0.1	0.6	0.5
High cholesterol (Self-reported)	0.5	0.8	2.7	0.1	0.6	1.4	-0.1	-1.6	0.2	-1.1	-0.6	0.3	0.9	1.3
Medication: Bendroflumethiazide	0.4	0.6	2.6	0.4	-1.2	1.1	-1.6	-0.0	0.0	-0.5	-0.7	0.0	-0.1	0.6
Medication: Paracetamol	0.4	0.6	2.0	-0.9	0.4	0.4	1.0	-0.3	0.6	-0.5	-0.6	0.8	1.4	-0.7
Medication: Lisinopril	0.7	0.9	3.8	0.4	0.3	1.9	-0.1	1.3	-0.4	0.0	-1.4	-0.1	1.3	0.3
Medication: Atorvastatin	0.8	1.0	3.1	-1.4	0.7	0.2	0.8	1.4	1.6	0.1	-0.0	0.5	1.8	-0.2
Illnesses of father: High blood pressure	0.9	1.1	2.2	-0.8	-0.6	1.4	1.1	-1.0	-0.4	-1.4	-0.2	0.9	1.2	1.5
Alcohol drinker status: Never	0.5	0.6	1.9	1.4	0.8	0.6	-1.4	0.0	-0.8	-0.1	-0.7	-0.9	-0.5	0.3
Ever smoked	0.3	0.4	3.7	-1.9	-0.5	-0.4	-0.4	-0.1	0.3	0.3	0.0	-0.3	-0.5	0.4
Basal metabolic rate	0.3	1.4	4.6	-0.7	0.5	-0.2	-1.9	0.2	0.2	-2.0	1.5	0.5	0.5	2.1
Leg fat percentage (left)	0.5	2.0	7.9	0.6	0.7	0.9	-2.3	-0.5	-1.7	-1.4	1.2	-0.4	-0.3	2.8
Arm fat-free mass (left)	0.3	1.5	5.1	-0.9	0.6	0.1	-1.8	0.7	0.0	-2.1	1.1	0.6	0.9	2.2
Number of operations (self-reported)	0.6	0.9	4.5	-2.1	-0.0	-0.1	0.7	-0.2	0.7	-0.9	-0.8	1.8	0.0	-0.0
Average weekly beer plus cider intake	0.9	1.3	4.1	0.0	1.3	0.1	-1.7	1.4	-0.6	1.4	0.8	-2.0	-0.3	0.4
Irritability	0.7	1.1	2.8	0.8	0.5	1.7	-1.7	0.9	-0.0	0.3	-1.7	-0.4	-1.3	-0.6
Risk taking	0.5	0.8	6.5	-0.5	-0.1	-0.9	0.4	2.6	-0.3	-0.1	0.3	0.9	-0.0	0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.9	0.9	1.6	0.2	-0.2	0.5	-0.7	-0.9	1.2	-0.6	0.5	1.7
Fractured/broken bones in last 5 years	0.8	1.1	5.1	-0.6	0.4	-2.3	0.4	0.5	0.7	-0.7	0.7	1.7	-0.1	-1.2
Age started oral contraceptive pill	0.6	0.7	2.5	0.4	0.2	-1.6	-0.6	-0.1	0.5	-0.2	1.6	0.1	-1.4	-0.1
Diastolic blood pressure, automated reading	0.3	1.0	3.4	1.3	-0.7	0.1	-0.8	-1.7	-0.2	-1.9	-0.4	1.1	0.6	0.8
Ever depressed for a whole week	0.9	1.1	3.2	0.5	-0.2	1.5	-0.1	-0.2	0.2	-0.1	-1.1	1.6	-1.6	-1.8
Unable to work because of sickness or disability	0.4	0.6	1.4	0.7	-1.0	1.0	-0.7	-0.8	0.3	-1.2	0.1	0.7	-0.7	0.4
Commuting to job workplace: Cycle	1.3	1.6	4.5	-1.1	0.9	-2.1	1.9	0.2	-0.7	-0.8	1.3	2.1	0.4	-0.6
Myopia	0.5	0.7	2.8	0.5	-0.6	-1.7	0.9	0.2	-0.5	0.8	1.3	-0.2	-0.6	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	4.9	0.9	-0.4	0.0	0.4	-0.9	-2.2	-0.3	-0.9	-0.6	-0.0	0.7
Cholesterol lowering medication	0.6	0.9	3.8	-0.6	-0.3	0.8	-0.5	0.3	-0.2	-1.8	-0.6	1.9	0.7	0.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	4.3	-2.1	1.0	0.2	0.7	1.6	0.8	1.2	-0.8	-0.2	0.1	-0.0
Pain experienced in last month	0.9	1.4	4.1	1.1	-0.2	-1.4	-0.7	1.0	-1.6	2.0	0.6	-0.5	-2.0	-0.5
Supplements: Calcium	0.7	0.8	3.1	-1.0	0.2	-1.4	-0.1	0.6	0.4	-0.3	0.4	1.8	-0.9	-1.2
Basal cell carcinoma (self-reported)	0.7	0.8	6.2	0.8	0.6	0.2	-0.0	2.5	-0.0	0.2	-0.2	-0.3	-1.1	0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.5	-1.0	1.2	0.8	-0.9	2.1	-1.0	0.6	0.1	-1.5	0.3	1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.0	-0.2	-0.7	-1.4	0.3	0.6	0.8	-0.6	0.8	0.8	0.5	0.0
Heart disease (siblings)	0.6	0.7	2.0	-0.4	1.3	0.7	-0.3	0.6	0.2	0.7	0.6	-1.0	1.4	1.1
Alcohol drinker status: Previous	0.2	0.3	0.9	-0.8	0.5	0.2	-0.4	0.3	-0.1	0.9	-0.5	-0.7	-0.2	0.3
Pack years of smoking	0.8	1.2	3.9	2.0	-1.7	0.8	-0.2	-1.9	1.1	-0.3	-0.9	0.1	0.0	-0.5
Impedance of whole body	0.3	1.7	4.8	-0.1	-1.2	-1.1	2.1	-1.1	-0.8	2.2	0.1	-1.4	-0.5	-1.7
Leg fat mass (left)	0.5	2.0	7.4	0.3	0.8	0.7	-2.6	-0.3	-1.2	-1.9	1.3	-0.0	-0.0	2.7
Arm predicted mass (left)	0.3	1.5	5.2	-1.0	0.7	0.0	-1.7	0.7	0.3	-2.0	1.2	0.6	0.8	2.3