Hub : Genes

HYOU1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0980	0.0430	0.0077	-0.004	NA	0.003	NA	-0.004	0.75000	NA	0.1900	NA	0.7500
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1030	0.0430	0.0035	0.005	NA	0.020	NA	0.012	0.16000	NA	0.0280	NA	0.0700
3	TCGA	Lung Adenocarcinoma	0.0643	0.0345	0.0074	0.026	0.01	0.020	NA	0.016	0.00049	0.023	0.0019	NA	0.0054

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.6	2.5	3.4	-1.1	1.7	1.8
Bipolar Disorder or Schizophrenia	2.1	5.0	10.4	-3.2	2.0	0.9
Depressed Affect (Nagel 2018)	0.7	1.5	2.9	-1.7	0.5	-1.2
Depression (Nagel 2018)	0.1	0.2	0.3	-0.2	0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.5	-1.2	0.7	-0.6
Neuroticism (Nagel 2018)	0.8	1.8	4.9	-0.6	0.1	-2.2
Schizophrenia (2018)	2.1	4.3	11.2	-3.4	1.2	-0.4
Schizophrenia vs Biploar Disorder	0.8	1.1	1.5	-1.1	0.9	-1.2
Worry (Nagel 2018)	1.1	2.4	5.1	0.1	-1.4	-2.3
Alzheimer’s Disease (in mother)	1.0	1.1	2.8	1.7	0.4	0.6
Alzheimer’s Disease (in father)	1.1	1.2	1.7	-0.4	-1.3	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	1.1	-0.3	0.0
Crohns Disease (2017)	0.4	0.8	1.4	1.2	0.6	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.6	0.8	0.1
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.4	0.4	-0.2
Major Depression (MDD)	0.2	0.3	0.9	-0.9	0.0	-0.2
Reaction Time	0.1	0.2	0.5	-0.3	-0.3	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-0.7	1.0	-0.3
Breast Cancer	1.7	4.0	5.7	1.3	2.1	2.4
Ovarian Cancer	0.1	0.2	0.3	0.5	-0.4	-0.2
Prostate Cancer	0.8	1.2	1.8	-0.8	1.4	1.0
Age at First Birth	0.2	0.3	0.6	-0.3	0.8	0.5
Bipolar Disorder (2011)	0.1	0.1	0.2	0.5	0.3	0.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.3	-0.2	0.8
Coronary Artery Disease (CAD)	1.7	2.0	3.7	1.5	0.0	1.9
Crohns Disease (2012)	0.2	0.3	0.7	-0.4	0.8	0.2
Mean Putamen Volume	1.6	1.8	3.0	0.4	1.7	1.5
Fasting Glucose	0.5	0.6	0.9	0.9	-0.5	-0.9
HbA1C	1.4	1.5	2.3	-1.5	0.2	-1.5
HDL Cholesterol	0.3	0.5	1.5	0.0	-0.4	-1.2
LDL Cholesterol	0.2	0.3	0.8	-0.9	0.3	0.3
Lupus	0.3	0.4	0.7	0.6	-0.9	-0.3
Neuroticism (2016)	0.2	0.3	0.4	0.5	0.4	-0.7
Primary Biliary Cirrhosis	0.4	0.6	1.1	-0.6	1.1	-0.6
Rheumatoid Arthritis	0.5	0.7	0.8	-0.9	0.7	-0.9
Schizophrenia (2014)	1.8	4.0	9.8	-3.1	1.5	0.1
Triglycerides	0.2	0.4	0.8	-0.1	0.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.3	-0.3	0.2
Ulcerative Colitis	0.2	0.3	0.8	-0.1	-0.1	-0.9
Blood Eosinophil Count	0.4	2.8	6.2	2.5	-1.4	0.5
Blood Platelet Count	4.1	48.1	73.3	-6.3	8.6	5.6
Blood Red Count	0.4	3.5	5.4	2.0	-1.1	2.3
Blood White Count	0.3	2.2	4.3	-2.1	1.3	0.7
Heel T-Score	0.3	2.3	5.6	1.1	2.4	0.3
BMI	0.1	0.6	1.1	0.9	-0.2	1.1
Height	0.2	4.6	13.2	0.7	3.6	0.4
Waist Hip Ratio (WHR)	0.3	1.3	2.3	-1.3	0.2	1.5
Systolic Blood Pressure	0.2	0.8	2.0	1.4	-0.5	0.2
Smoking Status	0.4	0.9	1.4	-0.5	1.2	1.0
Allergy or Eczema	2.4	6.3	14.9	-3.9	-0.9	-1.8
Cardiovascular Disease	1.0	3.2	6.8	0.8	-2.6	1.5
Hypothyroidism (self reported)	0.7	1.6	2.0	-1.4	-1.1	-1.2
Respiratory disease	1.0	2.3	5.6	-0.7	-1.0	-2.4
Type 2 Diabetes (T2D) (2018)	1.5	2.8	5.1	2.3	1.1	1.5
Lung FEV1/FVC ratio	1.5	7.8	17.3	-1.8	4.2	1.7
Lung FVC	0.4	1.9	2.1	-1.3	-1.4	-1.4
Neuroticism	0.7	1.7	3.9	-1.1	-0.1	-2.0
Chronotype (morning person)	0.1	0.3	0.6	0.3	0.8	0.5
Hair Pigment	0.2	5.4	12.5	-0.3	1.9	3.5
Tanning	0.0	0.1	0.1	-0.1	0.2	-0.4
Hand grip strength (left)	1.4	3.6	8.2	-1.5	0.7	-2.9
Number of treatments/medications taken	1.2	2.2	5.4	-1.0	-2.3	-0.4
Average weekly spirits intake	1.7	2.1	5.7	-0.3	-0.8	-2.4
Sensitivity / hurt feelings	0.9	1.5	3.6	-0.9	-0.4	-1.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	0.8	0.1	-1.2
Hearing difficulty/problems: Yes	1.2	1.8	4.1	-2.0	-1.1	0.3
Relative age of first facial hair	1.0	2.1	3.7	-1.7	1.9	-0.1
Other serious medical condition/disability diagnosed by doctor	4.9	6.3	9.6	-3.1	-1.9	-2.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.1	-0.7	-0.9	-1.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.1	-0.5	-0.0
Systolic blood pressure, automated reading	0.1	0.3	0.9	0.9	-0.1	0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	1.3	-0.0	1.0
Angina	0.7	0.9	2.4	-0.4	-0.3	1.5
Medication for hormone replacement therapy	0.4	0.4	1.0	-0.4	-0.4	-1.0
Vitamin and mineral supplements	0.3	0.4	0.7	-0.7	0.3	-0.9
Supplements: Zinc	1.8	2.0	3.1	-1.8	-1.6	0.3
Medication: Co-codamol	2.5	2.9	6.0	1.3	-2.5	-1.0
Medication: Metformin	1.1	1.6	4.4	0.5	0.2	2.1
Diabetes (father)	1.0	1.2	2.7	0.7	-1.6	-0.8
Diabetes (mother)	0.2	0.2	0.6	0.8	-0.3	-0.1
Severe depression (siblings)	1.4	1.6	2.7	-1.7	-0.4	1.4
Pack years adult smoking proportion	0.0	0.1	0.2	0.4	-0.0	0.1
Impedance of leg (right)	0.7	3.2	7.3	0.2	2.7	1.5
Leg fat-free mass (left)	0.1	0.6	1.1	0.8	-0.1	-1.1
Trunk fat percentage	0.4	1.7	2.7	1.6	0.5	1.4
Hand grip strength (right)	0.8	2.3	2.9	-1.7	1.3	-1.5
Townsend deprivation index at recruitment	2.3	3.2	8.2	-1.1	-2.9	-0.0
Current tobacco smoking	0.6	1.0	1.6	-1.3	0.8	0.8
Average weekly fortified wine intake	0.8	0.9	1.7	0.5	-1.3	-0.9
Maternal smoking around birth	0.5	0.7	1.2	-1.1	0.9	0.5
Fed-up feelings	0.5	0.9	2.2	-0.6	-0.4	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	-1.0	1.2	-0.4
Relative age voice broke	2.3	3.5	7.9	-1.3	2.8	0.9
Taking other prescription medications	4.2	6.4	10.9	-3.3	-2.2	-1.9
Age when periods started (menarche)	1.2	2.8	4.8	0.6	2.2	-1.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	1.1	0.2	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.5	0.8	1.2	-0.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	1.9	0.8	-1.4	1.0
Qualifications: CSEs or equivalent	0.8	1.1	3.1	-1.8	0.3	-0.0
Serious illness, injury or assault to yourself	0.3	0.3	0.6	-0.8	-0.4	-0.5
High blood pressure	1.2	3.3	9.5	0.6	-3.1	0.5
Hayfever, allergic rhinitis or eczema	1.6	3.4	5.2	-2.3	-0.7	-2.1
Multivitamins +/- minerals	0.7	0.8	1.4	1.2	-0.9	0.5
Stomach or abdominal pain in last month	1.7	2.1	2.8	0.9	1.6	1.7
Supplements: Glucosamine	0.1	0.1	0.2	-0.4	-0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.9	0.3	0.1
Medication: Atenolol	3.9	4.9	11.5	0.9	-3.4	-1.5
Medication: Levothyroxine sodium	1.4	2.4	4.2	-1.5	-2.0	-0.8
Sitting height	0.1	0.9	1.4	-0.3	1.2	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.9	0.5	-0.6
High blood pressure (mother)	0.6	0.8	2.2	0.5	-1.5	-0.2
Body mass index (BMI)	0.2	0.7	1.5	0.7	-1.2	0.4
Impedance of leg (left)	0.8	3.9	7.5	0.8	2.7	1.9
Leg predicted mass (left)	0.1	0.7	1.3	0.8	-0.1	-1.2
Trunk fat mass	0.4	1.6	3.1	1.8	0.9	1.0
Waist circumference	0.1	0.5	1.1	0.6	-0.1	1.1
Number of incorrect matches in round	0.3	0.6	1.6	-1.3	0.1	0.2
Past tobacco smoking	0.0	0.1	0.1	0.1	-0.2	-0.3
Alcohol usually taken with meals	1.5	2.4	3.5	1.8	1.9	0.6
Nervous feelings	1.2	2.2	3.1	0.6	-1.8	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.0	-0.4	0.1
Hearing difficulty/problems with background noise	0.6	0.9	1.8	-1.3	-0.5	0.9
Hair/balding pattern: Pattern 2	1.3	1.6	4.6	-0.2	2.1	0.4
Had menopause	0.2	0.2	0.3	-0.2	0.5	0.6
Had other major operations	0.9	1.1	1.7	1.3	1.0	0.8
Forced vital capacity (FVC)	0.2	0.9	2.1	0.7	0.3	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.4	1.4	1.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.6	-0.7	-0.2	-1.6
Qualifications: None of the above	2.1	4.4	10.3	1.5	-3.2	0.8
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.3	-0.4	0.1
Mouth/teeth dental problems	1.3	1.9	3.9	-1.1	-0.9	-2.0
Heart attack	0.2	0.2	0.6	-0.8	-0.2	0.3
Allergy	1.8	4.1	6.2	2.3	1.0	2.5
Pain all over the body in last month	0.2	0.2	0.5	-0.1	0.4	0.7
Diabetes (self-reported)	1.0	1.5	2.2	1.5	0.5	1.4
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.7	-2.4	0.0	-0.6
Medication: Ramipril	1.2	1.5	2.0	-0.9	-1.4	1.4
Medication: Simvastatin	0.9	1.4	2.7	1.0	0.7	1.7
Fluid intelligence score	0.4	0.9	1.4	-1.2	1.2	0.1
Illnesses of siblings	0.1	0.2	0.4	0.1	-0.1	-0.7
Neuroticism score	1.0	2.0	4.7	-1.0	-0.6	-2.2
Weight	0.1	0.5	1.4	1.2	0.4	0.2
Impedance of arm (right)	0.4	1.7	3.0	1.1	1.7	1.0
Arm fat percentage (right)	0.3	1.3	3.0	1.7	-0.4	0.9
Trunk fat-free mass	0.1	0.5	1.1	0.4	0.6	-1.0
Hip circumference	0.1	0.3	1.0	1.0	0.0	0.2
Time employed in main current job	0.4	0.5	0.9	-0.3	-0.9	-0.7
Alcohol intake versus 10 years previously	0.9	1.3	3.0	0.9	-1.7	0.4
Father’s age at death	1.8	2.5	3.3	-1.8	-0.9	-1.8
Worrier / anxious feelings	1.0	1.8	2.9	0.6	-1.5	-1.7
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	6.0	-1.0	-2.4	-2.0
Falls in the last year	2.5	3.3	5.4	-1.9	-2.3	-1.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	-1.3	0.1	0.7
Number of live births	1.0	1.4	3.1	-0.9	0.6	1.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	-0.1	0.7	-0.7
Pulse rate	0.1	0.2	0.5	-0.7	0.3	-0.0
Happiness	2.0	2.5	6.6	0.1	0.9	-2.6
Noisy workplace	0.1	0.1	0.2	-0.4	-0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.6	1.1	-0.3	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.6	1.0	0.5	-1.9
Mouth/teeth dental problems: Dentures	1.3	2.1	5.3	-0.8	0.6	2.3
Asthma	0.6	1.2	2.9	-0.2	-1.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.7	-1.2	-0.1	-1.6
Medication: Cholesterol lowering	0.7	1.1	3.3	0.1	0.2	1.8
Depression (self-reported)	0.4	0.5	1.3	0.1	-1.1	-0.5
Medication: Lansoprazole	0.9	1.0	1.8	1.3	-0.9	0.8
Prospective memory result	0.7	0.8	2.3	1.5	-0.3	-0.3
Lung cancer (father)	0.1	0.1	0.3	0.5	0.4	0.0
Illnesses of mother	1.0	1.3	3.2	-0.8	-0.1	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.4	-0.9	1.9	-0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.9	-0.1	0.4
Impedance of arm (left)	0.2	0.8	1.3	0.6	1.1	0.8
Arm fat mass (right)	0.2	0.6	1.5	1.2	-0.5	0.4
Trunk predicted mass	0.1	0.6	1.2	0.3	0.6	-1.1
Standing height	0.4	3.6	8.8	1.1	3.0	-0.8
Length of working week for main job	0.7	0.7	1.2	-0.7	1.1	0.7
Exposure to tobacco smoke at home	0.5	0.5	1.0	1.0	0.4	0.6
Breastfed as a baby	0.4	0.5	1.2	-1.1	0.6	-0.1
Tense / ‘highly strung’	0.4	0.6	0.9	-0.2	0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	0.3	-1.1	-1.4
Hair/balding pattern: Pattern 4	0.7	1.7	4.1	2.0	-0.8	-0.7
Birth weight of first child	1.7	3.2	9.2	3.0	0.6	0.0
Peak expiratory flow (PEF)	0.5	1.1	1.8	-1.3	0.5	-1.2
Pulse wave reflection index	0.8	0.9	2.0	1.4	0.8	0.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.0	1.1	-0.8	-1.4
Loud music exposure frequency	0.2	0.2	0.3	0.3	0.5	0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.3	0.6	-0.5	-2.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	0.5	0.2	0.8
Blood clot in the leg (DVT)	1.9	2.5	3.0	-1.4	-1.5	-1.7
Medication: Paracetamol	0.1	0.1	0.2	-0.4	-0.4	0.2
Headache pain in last month	0.1	0.2	0.5	-0.4	0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.3	0.6	1.1	-1.5
Glaucoma (self-reported)	1.4	1.6	4.1	0.7	0.5	2.0
Gout (self-reported)	1.0	1.3	2.3	-1.5	0.5	-1.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.9	-1.7	-1.1	-1.0
Medication: Amlodipine	0.0	0.0	0.1	-0.1	0.3	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.2	-0.3	1.1	1.0
Birth weight	0.7	1.5	4.2	0.5	2.0	0.2
Chronic bronchitis/emphysema (mother)	2.4	2.8	4.7	2.2	1.0	1.6
High blood pressure (siblings)	0.1	0.2	0.3	-0.5	-0.1	0.5
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	-0.3	1.3	-1.1
Body fat percentage	0.4	1.7	2.6	1.6	0.4	1.5
Leg fat percentage (right)	0.3	0.9	1.6	1.1	0.4	1.2
Arm fat-free mass (right)	0.1	0.5	1.0	0.2	0.6	-1.0
Exposure to tobacco smoke outside home	0.7	0.9	2.6	1.6	0.2	-0.1
Comparative body size at age 10	0.5	1.3	2.4	0.1	-1.6	-1.3
Number of full brothers	1.9	2.4	4.6	-0.7	2.1	1.4
Worry too long after embarrassment	0.6	1.1	2.0	-0.7	-0.8	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	0.6	-1.1	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.5	0.8	0.3
Number of children fathered	0.0	0.0	0.1	0.0	-0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.4	-1.9	0.9	-1.7
Age at first live birth	0.4	0.7	1.5	0.3	1.2	-0.6
Pulse wave peak to peak time	0.4	0.4	0.8	-0.9	0.2	-0.7
Health satisfaction	0.8	1.0	1.9	-1.4	-0.9	-0.4
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.1	-0.4	-0.1
Qualifications: College or University degree	0.3	0.8	1.4	1.2	0.1	-1.0
Eye problems/disorders: None of the above	0.6	0.7	0.9	-0.9	1.0	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.2	0.7	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.5	-0.1	1.2	0.5
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.2	0.3	0.2
Neck or shoulder pain in last month	0.7	1.0	1.8	0.9	-0.6	-1.3
Medication: Blood pressure	0.8	1.4	2.9	-0.5	-0.9	1.7
Angina (self-reported)	0.7	0.9	2.2	-0.6	-0.3	1.5
Migraine (self-reported)	0.5	0.6	1.2	0.4	-0.6	-1.1
Medication: Ibuprofen	0.6	0.8	1.3	-1.1	0.1	-1.0
Medication: Allopurinol	2.6	3.5	7.8	-2.8	0.5	-1.6
Medication: Omeprazole	0.3	0.4	0.7	0.9	-0.5	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.4	-0.4	0.5	0.7
Mean time to correctly identify matches	0.3	0.6	1.6	-0.3	0.3	1.3
Heart disease (mother)	1.0	1.2	3.6	-1.9	0.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.8	0.1	-0.8	-1.7
Whole body fat mass	0.4	1.8	3.7	1.9	0.7	1.1
Leg fat mass (right)	0.2	0.9	2.3	1.5	0.2	0.7
Arm predicted mass (right)	0.1	0.4	1.0	0.2	0.3	-1.0
Pulse rate, automated reading	0.3	0.8	1.7	-0.0	1.3	0.8
Alcohol intake frequency.	2.7	6.2	13.2	3.6	-1.5	1.7
Comparative height size at age 10	0.1	0.4	0.8	0.9	0.6	0.3
Number of full sisters	1.2	1.5	1.9	-1.2	1.0	1.4
Suffer from ‘nerves’	1.4	2.2	4.5	-0.7	-1.3	-2.1
Overall health rating	0.7	1.4	4.2	-0.4	-2.0	0.1
Chest pain or discomfort	0.5	0.7	2.2	-0.2	0.1	1.5
Had major operations	0.6	0.7	1.8	1.4	0.4	-0.0
Age at last live birth	0.5	0.7	1.8	0.2	-0.3	-1.3
Family relationship satisfaction	0.6	0.7	1.2	-0.4	1.1	0.9
Leg pain on walking	1.6	2.0	3.0	-1.5	-1.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.2	-1.8	1.2	0.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.2	-0.9	1.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.3	0.1	0.8
Medication: Aspirin	0.9	1.1	1.9	-0.2	-1.4	-1.2
Supplements: Vitamin C	1.1	1.3	2.7	0.3	1.6	1.1
Knee pain experienced in last month	0.5	0.8	2.4	0.2	-1.6	-0.2
Hypertension (Self-reported)	1.1	3.1	9.1	-0.2	-3.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.7	-0.5	-1.6	-0.9
Illnesses of father: Heart disease	0.7	0.9	1.9	-0.6	-0.7	-1.4
Illnesses of siblings: Diabetes	0.4	0.4	1.0	0.5	-0.2	1.0
Smoking status: Previous	0.1	0.2	0.4	0.4	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.2	0.1	0.4
Whole body fat-free mass	0.1	0.5	1.2	0.4	0.4	-1.1
Leg fat-free mass (right)	0.1	0.8	1.1	1.1	-0.3	-1.1
Arm fat percentage (left)	0.3	1.1	2.2	1.5	-0.7	0.7
Average weekly red wine intake	1.2	1.8	2.6	-0.8	1.6	-1.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.7	-0.3	-1.6	-0.3
Mood swings	0.3	0.5	0.9	-0.7	-0.5	-0.9
Loneliness, isolation	1.5	2.1	5.3	-2.3	0.8	-0.5
Long-standing illness, disability or infirmity	4.5	6.9	11.4	-3.4	-2.8	-1.3
Ever had bowel cancer screening	0.7	0.9	1.9	-1.4	0.3	0.8
Diabetes diagnosed by doctor	1.3	2.2	2.7	1.7	1.1	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.1	0.1	-0.0	0.2	-0.3
Friendships satisfaction	0.2	0.3	0.5	-0.4	0.7	0.3
Qualifications: nursing, teaching	0.6	1.0	2.5	0.4	-0.4	-1.6
Commuting to job workplace: Walk	0.4	0.4	1.2	0.3	-1.1	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.1	-0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.0	1.4	0.6	-1.1
Medication for cholesterol	1.2	1.8	3.5	-0.9	1.9	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	0.1	-1.0	0.3
Back pain experienced in last month	1.7	2.4	4.7	-1.6	-2.2	-0.1
Mineral and other dietary supplements	0.2	0.2	0.6	0.1	-0.1	-0.8
Breast cancer (self-reported)	0.3	0.4	1.0	-1.0	0.2	-0.2
Asthma (self-reported)	0.7	1.4	2.7	-0.5	-1.6	-1.1
Osteoporosis (self-reported)	0.6	0.7	1.1	-0.8	-0.7	-1.0
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.6	-0.4	0.9
Medication: Aspirin	0.6	0.8	1.1	-0.2	-1.1	-1.1
Medication: Gliclazide	0.3	0.3	0.5	0.4	0.6	0.7
Illnesses of father: None of the above (group 1)	0.9	1.1	2.4	1.0	0.4	1.5
Smoking status: Current	0.7	1.1	2.0	-1.4	0.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-0.6	0.3	-1.1
Whole body water mass	0.1	0.6	1.5	0.5	0.4	-1.2
Leg predicted mass (right)	0.1	0.7	1.1	1.0	-0.2	-1.0
Arm fat mass (left)	0.2	0.7	1.7	1.3	-0.6	0.2
Number of self-reported non-cancer illnesses	2.0	3.5	7.0	-1.0	-2.6	-1.6
Average weekly champagne plus white wine intake	0.6	0.8	2.1	-0.2	1.5	-0.4
Miserableness	0.4	0.8	0.9	-1.0	-0.8	-0.9
Guilty feelings	0.4	0.7	1.5	-0.6	1.2	-0.5
Wears glasses or contact lenses	0.6	0.7	1.3	-0.8	-0.6	-1.1
Ever taken oral contraceptive pill	0.4	0.5	0.9	0.1	0.7	1.0
Hearing aid user	3.0	3.4	9.2	-0.7	-3.0	-0.6
Mother’s age at death	0.2	0.2	0.3	0.6	-0.5	0.2
Financial situation satisfaction	0.7	0.9	2.3	-0.4	-0.5	-1.5
Tinnitus: Yes, now most or all of the time	2.6	3.0	4.5	-2.1	-0.9	-1.9
Commuting to job workplace: Public transport	0.9	1.1	2.1	0.8	-1.5	-0.8
Eye problems/disorders: Glaucoma	0.7	0.9	2.6	0.1	-0.2	1.6
Medication: Blood pressure	1.8	3.4	9.2	0.4	-3.0	-0.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.9	-0.1	-2.2	-1.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	1.3	-0.1	-0.1
High cholesterol (Self-reported)	0.2	0.4	1.0	0.3	0.0	1.0
Medication: Bendroflumethiazide	1.4	2.1	5.8	0.7	-2.4	-0.0
Medication: Paracetamol	0.4	0.6	1.1	-0.7	0.3	1.0
Medication: Lisinopril	0.4	0.6	1.3	0.5	-1.2	0.4
Medication: Atorvastatin	0.7	0.8	2.3	-0.1	-1.5	0.5
Illnesses of father: High blood pressure	2.9	3.6	7.4	0.1	-1.8	-2.7
Alcohol drinker status: Never	1.2	1.5	3.1	1.8	-0.8	0.8
Ever smoked	0.1	0.2	0.6	-0.1	0.7	0.3
Basal metabolic rate	0.1	0.4	0.7	0.7	0.4	-0.8
Leg fat percentage (left)	0.4	1.3	1.9	1.4	0.4	1.4
Arm fat-free mass (left)	0.1	0.5	1.1	0.1	0.6	-1.1
Number of operations (self-reported)	0.2	0.4	0.9	0.2	0.9	-0.4
Average weekly beer plus cider intake	0.8	1.2	2.4	-1.6	0.3	1.0
Irritability	0.4	0.6	1.3	-0.2	0.7	-1.1
Risk taking	1.7	2.4	5.1	-1.4	2.3	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	-0.6	0.7	0.4
Fractured/broken bones in last 5 years	1.2	1.6	4.0	-2.0	-0.3	0.8
Age started oral contraceptive pill	1.0	1.3	3.2	-0.5	1.8	-0.5
Diastolic blood pressure, automated reading	0.5	1.6	3.3	-1.1	1.8	0.3
Ever depressed for a whole week	0.5	0.6	1.7	0.1	0.3	-1.3
Unable to work because of sickness or disability	0.7	0.9	2.5	-0.6	-0.2	1.6
Commuting to job workplace: Cycle	1.0	1.2	1.8	-0.8	1.0	1.3
Myopia	0.4	0.6	0.8	0.7	-0.8	-0.9
Vascular/heart problems diagnosed by doctor	1.1	3.1	9.0	0.1	3.0	-0.4
Cholesterol lowering medication	0.4	0.6	1.4	0.7	-1.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.1	-0.5	0.2
Pain experienced in last month	1.0	1.7	3.6	0.6	1.9	1.0
Supplements: Calcium	2.4	2.6	6.1	-2.5	0.4	1.3
Basal cell carcinoma (self-reported)	2.2	2.6	4.2	-0.3	1.9	2.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.5	0.0	0.6
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	2.9	-1.2	-1.6	-1.7
Heart disease (siblings)	0.3	0.3	0.8	0.5	0.9	0.0
Alcohol drinker status: Previous	0.3	0.3	0.7	0.4	0.8	0.4
Pack years of smoking	0.0	0.0	0.0	0.1	-0.2	0.0
Impedance of whole body	0.5	2.5	5.0	0.5	2.2	1.5
Leg fat mass (left)	0.3	1.3	3.0	1.7	0.5	0.9
Arm predicted mass (left)	0.1	0.6	1.2	0.5	0.6	-1.1