Hub : Genes

IGSF9B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.13 0.048 1.4e-03 0.009 NA 0.034 NA 0.040 5.3e-02 NA 7.7e-04 NA 3.0e-04
2 GTEx Spleen 0.27 0.093 6.0e-03 0.012 NA -0.007 NA -0.009 1.5e-01 NA 5.4e-01 NA 6.3e-01
3 GTEx Testis 0.19 0.074 6.1e-03 0.087 NA 0.068 NA 0.100 1.0e-04 NA 6.1e-04 NA 3.4e-05
4 GTEx Thyroid 0.28 0.060 1.3e-06 0.202 NA 0.218 NA 0.216 2.3e-15 NA 1.2e-16 NA 1.8e-16
5 GTEx Whole Blood 0.11 0.035 4.6e-04 0.032 NA 0.056 NA 0.042 5.3e-04 NA 7.2e-06 NA 9.3e-05
6 YFS Blood 0.06 0.016 3.8e-07 0.027 0.025 0.025 0.032 0.029 1.9e-09 9.4e-09 1.3e-08 1e-10 6.3e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Alzheimer’s Disease (in mother) 1.0 1.2 2.1 0.3 1.2 1.4 1.5 0.9 -0.8
Alzheimer’s Disease (in father) 0.3 0.3 1.2 0.0 0.2 0.5 0.4 1.1 -0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.3 -0.0 0.5 0.4 0.4 -0.1
Crohns Disease (2017) 1.5 3.4 5.7 1.0 -2.2 -2.4 -2.4 -1.1 1.4
Irritable Bowel Disease (IBD) 1.4 3.3 5.8 0.4 -2.4 -2.0 -2.1 -0.9 2.1
Ulcerative Colitis (UC) 1.1 2.0 4.5 -0.4 -2.1 -1.3 -1.6 -0.6 1.6
Major Depression (MDD) 0.2 0.3 1.0 0.2 0.2 -1.0 -0.6 -0.3 -0.5
Reaction Time 3.1 6.0 10.2 -0.2 -3.2 -2.7 -3.1 -3.0 -0.1
Verbal and Numeric Reasoning (VNR) 1.2 3.0 6.8 0.0 1.0 2.4 2.6 2.1 -0.1
Breast Cancer 0.3 0.8 2.4 -0.9 0.0 0.6 0.6 1.0 1.6
Ovarian Cancer 0.1 0.2 0.4 0.5 -0.4 -0.0 -0.3 -0.1 0.6
Prostate Cancer 1.5 2.2 3.7 0.5 -1.9 -1.6 -1.7 -1.6 -0.9
Age at First Birth 0.9 1.3 6.1 -2.5 -0.4 0.1 -0.0 0.9 0.9
Bipolar Disorder 4.1 4.0 21.6 -4.7 0.1 0.1 -0.4 -0.5 -1.4
Body Mass Index (BMI) (2010) 0.8 1.1 3.6 -0.7 0.9 1.0 0.9 1.9 -0.2
Coronary Artery Disease (CAD) 0.2 0.3 0.9 1.0 -0.2 -0.4 -0.1 -0.3 -0.7
Crohns Disease (2012) 0.9 1.4 3.1 -0.7 1.2 1.8 1.6 1.0 -0.1
Mean Putamen Volume 0.7 0.8 2.2 1.3 -0.4 -0.2 -0.3 0.8 1.5
Fasting Glucose 0.6 0.7 2.6 -1.6 -0.0 -0.3 -0.1 -1.1 -0.3
HbA1C 0.2 0.2 0.7 -0.5 0.1 0.2 -0.0 0.8 0.2
HDL Cholesterol 0.4 0.7 1.5 -1.2 -1.1 -0.4 -0.4 0.4 1.1
LDL Cholesterol 0.7 1.1 1.9 0.7 1.1 1.1 1.1 1.4 -0.7
Lupus 2.2 3.3 8.3 0.1 1.8 1.6 1.9 2.9 -1.4
Neuroticism 3.0 4.4 6.9 -1.8 -2.3 -2.5 -2.3 -2.6 0.4
Primary Biliary Cirrhosis 1.5 2.1 5.9 -2.4 0.8 1.3 1.2 1.3 -1.1
Rheumatoid Arthritis 1.7 2.3 4.0 0.0 -1.4 -1.9 -2.0 -1.8 1.0
Schizophrenia 10.2 22.8 43.0 -1.2 -4.2 -6.6 -6.3 -6.0 0.6
Triglycerides 0.1 0.2 0.5 -0.6 -0.2 0.7 0.3 0.7 -0.0
Type 2 Diabetes (T2D) 3.3 3.8 8.3 -2.5 1.4 1.9 1.6 2.9 0.5
Ulcerative Colitis 0.8 1.2 2.0 -0.0 1.4 1.2 1.2 0.7 -1.2
Blood Eosinophil Count 0.4 3.3 5.7 -2.3 1.8 1.3 1.1 1.6 -2.4
Blood Platelet Count 0.1 1.0 5.0 -0.6 -0.1 -0.2 -0.5 -0.1 -2.2
Blood Red Count 0.1 1.3 2.8 1.4 0.7 1.0 1.0 1.7 0.8
Blood White Count 0.1 0.9 1.6 0.7 1.3 1.2 0.9 0.6 -0.8
Heel T-Score 0.1 1.0 5.3 -2.3 -0.6 -0.6 -0.1 0.0 0.1
BMI 0.1 0.8 1.8 0.0 1.3 0.7 0.1 1.3 0.9
Height 0.0 0.5 1.1 0.8 -0.6 -0.4 -0.4 -1.0 -1.0
Waist Hip Ratio (WHR) 0.4 1.8 6.9 2.6 -0.7 1.5 0.8 -0.2 0.4
Systolic Blood Pressure 0.6 3.0 13.8 3.7 1.9 0.1 0.4 -0.6 -0.4
Smoking Status 0.9 2.2 5.9 -0.5 -0.2 -0.9 -1.1 -2.2 -2.4
Allergy or Eczema 0.0 0.1 0.4 0.1 -0.3 0.1 -0.1 0.6 -0.1
Cardiovascular Disease 1.2 4.1 12.6 1.0 -1.2 -2.1 -2.2 -3.5 -0.5
Hypothyroidism (self reported) 0.6 1.4 1.9 -1.3 -1.4 -1.3 -1.2 -0.6 1.2
Respiratory disease 2.6 5.7 13.8 -2.2 2.0 2.4 1.9 3.7 -1.4
Type 2 Diabetes (T2D) 1.0 1.9 4.1 -1.2 1.4 2.0 1.5 1.0 0.7
Lung FEV1/FVC ratio 0.1 0.5 1.5 0.6 1.2 0.6 0.9 0.2 -0.1
Lung FVC 0.7 3.6 6.7 0.1 2.6 1.7 2.2 1.5 -2.2
Neuroticism 8.5 20.8 33.5 -2.3 -5.8 -5.2 -5.4 -4.7 2.8
Chronotype (morning person) 0.2 0.5 1.8 0.3 -0.8 -0.5 -0.5 -1.3 0.1
Hair Pigment 0.1 2.3 4.3 -0.3 -1.2 -1.8 -2.1 -1.7 -1.1
Tanning 0.0 0.2 1.0 1.0 -0.1 0.1 0.1 0.4 -0.5
Hand grip strength (left) 5.4 14.4 25.1 -0.1 -5.0 -4.6 -4.7 -2.9 3.0
Number of treatments/medications taken 0.2 0.4 0.8 -0.5 -0.4 -0.7 -0.4 -0.9 -0.8
Average weekly spirits intake 1.9 2.3 4.6 1.4 -2.2 -1.3 -1.4 -0.4 1.9
Sensitivity / hurt feelings 5.9 10.4 16.5 1.0 3.6 4.0 3.8 4.1 -1.3
Frequency of depressed mood in last 2 weeks 5.0 7.1 11.9 0.6 3.5 3.4 3.3 2.5 -1.3
Hearing difficulty/problems: Yes 1.1 1.7 3.7 1.9 0.4 1.3 1.0 1.2 1.4
Relative age of first facial hair 1.2 2.5 7.3 0.1 1.6 1.4 1.6 2.7 0.8
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 6.7 2.6 -0.6 -0.4 -0.1 -0.2 0.8
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.3 0.5 0.7 0.6 0.4 1.1 -1.8
Ever had hysterectomy (womb removed) 0.2 0.3 1.2 -0.3 0.6 0.1 0.2 0.0 -1.1
Systolic blood pressure, automated reading 0.8 2.5 11.8 -3.4 -1.4 -0.1 -0.0 1.0 0.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 0.5 -0.8 0.1 0.1 0.9 -0.3
Angina 0.1 0.2 0.8 0.9 -0.0 -0.1 -0.0 0.4 -0.4
Medication for hormone replacement therapy 0.2 0.3 1.3 -0.3 0.2 0.1 -0.1 -0.5 -1.1
Vitamin and mineral supplements 0.9 1.2 4.5 1.1 -0.9 -0.6 -0.7 -0.3 2.1
Supplements: Zinc 1.2 1.3 2.3 1.3 -1.1 -0.9 -1.0 -1.5 -1.0
Medication: Co-codamol 1.6 1.9 2.9 -1.4 1.3 1.4 1.7 1.7 -0.5
Medication: Metformin 0.4 0.6 1.3 1.2 -0.2 -0.3 -0.2 1.1 -0.8
Diabetes (father) 0.9 1.1 1.7 -0.6 -1.3 -1.2 -0.8 -0.9 1.1
Diabetes (mother) 0.5 0.7 2.1 1.4 -1.2 -0.4 -0.3 -0.6 0.2
Severe depression (siblings) 0.3 0.3 1.0 -0.1 0.3 1.0 0.7 0.4 -0.4
Pack years adult smoking proportion 2.1 3.2 5.5 0.0 1.8 1.9 2.3 2.1 -1.6
Impedance of leg (right) 0.2 0.9 2.1 -1.5 -0.3 -0.9 -1.1 -0.1 1.1
Leg fat-free mass (left) 0.0 0.2 1.0 0.0 -0.5 -0.1 0.1 -0.4 -1.0
Trunk fat percentage 0.2 0.9 2.5 -0.3 -1.1 -1.6 -0.9 -1.0 -0.2
Hand grip strength (right) 3.5 9.6 16.4 0.6 -4.0 -3.2 -3.6 -2.6 3.2
Townsend deprivation index at recruitment 0.3 0.4 0.9 -0.6 0.2 1.0 0.9 0.4 -0.4
Current tobacco smoking 0.6 1.0 4.2 0.9 -0.2 0.1 0.3 0.9 2.0
Average weekly fortified wine intake 1.2 1.4 4.0 2.0 -0.8 -0.6 -0.6 -0.2 1.7
Maternal smoking around birth 3.9 5.7 11.8 -0.3 2.6 3.1 3.4 1.6 -1.9
Fed-up feelings 1.5 2.8 5.5 0.6 1.9 2.0 2.3 1.8 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 7.6 10.2 17.5 1.6 4.2 3.8 3.8 2.8 -2.2
Relative age voice broke 0.9 1.4 3.4 0.2 1.8 1.2 1.2 1.0 -1.1
Taking other prescription medications 1.0 1.6 2.4 0.4 1.5 1.3 1.5 1.5 -0.9
Age when periods started (menarche) 0.4 1.1 3.6 -1.9 -0.1 -0.6 -0.8 0.0 1.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.7 -0.0 0.6 -0.1 -0.1 -0.5 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.3 0.2 0.8 1.1 0.8 0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.5 -0.7 0.4 0.1 -0.1 -0.0 0.3
Qualifications: CSEs or equivalent 1.6 2.1 5.3 0.9 0.7 2.3 2.2 1.1 0.2
Serious illness, injury or assault to yourself 0.4 0.5 1.5 -1.2 -0.3 -0.7 -0.6 -0.3 -0.7
High blood pressure 0.5 1.3 4.0 -1.6 0.1 0.9 0.9 2.0 0.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 0.3 0.8 0.2 0.4 -0.7 -0.1
Multivitamins +/- minerals 1.1 1.4 4.5 -1.6 0.1 -0.8 -0.8 -0.5 -2.1
Stomach or abdominal pain in last month 1.3 1.6 5.3 1.1 -1.3 -0.8 -0.7 -0.1 2.3
Supplements: Glucosamine 1.4 1.9 3.7 -0.2 -1.8 -1.7 -1.9 -1.2 -0.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.8 0.8 -1.4 -0.5 -0.6 0.4 0.8
Medication: Atenolol 0.9 1.1 3.0 1.2 0.8 0.7 0.9 1.7 -0.1
Medication: Levothyroxine sodium 1.5 2.6 5.4 -0.1 1.6 1.6 1.8 1.2 -2.3
Sitting height 0.1 0.4 1.1 1.0 0.5 0.7 0.4 0.7 -0.1
Chronic bronchitis/emphysema (father) 0.4 0.4 0.8 -0.3 -0.8 -0.8 -0.9 -0.5 -0.0
High blood pressure (mother) 2.1 2.9 4.9 0.4 -2.2 -2.1 -2.1 -1.8 0.9
Body mass index (BMI) 0.2 1.0 1.9 0.6 -1.4 -1.2 -0.6 -1.0 -1.0
Impedance of leg (left) 0.1 0.5 1.0 -1.0 0.2 -0.8 -0.8 -0.0 1.0
Leg predicted mass (left) 0.0 0.2 0.9 0.0 -0.5 -0.1 0.1 -0.4 -1.0
Trunk fat mass 0.2 0.8 1.7 -0.4 -1.1 -1.3 -0.6 -0.9 -0.5
Waist circumference 0.1 0.3 0.6 -0.6 -0.6 -0.8 0.0 -0.2 -0.5
Number of incorrect matches in round 2.0 3.3 6.4 0.2 1.6 2.3 2.5 2.1 -1.0
Past tobacco smoking 0.7 1.3 2.5 -0.4 -0.3 -1.1 -1.3 -1.6 -1.5
Alcohol usually taken with meals 0.3 0.5 2.3 0.5 -0.3 -0.1 -0.5 -0.0 1.5
Nervous feelings 3.3 6.3 10.3 1.3 2.6 3.0 3.2 2.9 -1.2
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.6 1.5 1.4 1.6 1.6 1.1 -0.1
Hearing difficulty/problems with background noise 2.9 4.7 8.8 1.5 2.3 3.0 2.8 2.0 -0.2
Hair/balding pattern: Pattern 2 0.7 0.9 2.9 1.7 -0.5 -0.9 -0.7 -0.5 0.8
Had menopause 0.5 0.7 2.0 -0.4 1.0 -0.1 0.1 1.4 -1.0
Had other major operations 0.2 0.3 0.5 0.1 -0.6 -0.7 -0.4 0.5 0.7
Forced vital capacity (FVC) 0.8 3.1 5.9 -1.1 -2.4 -1.5 -1.8 -1.1 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.7 1.3 0.3 0.6 0.2 0.3 -0.3
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.2 0.5 1.2 2.0 2.0 2.0 0.0
Qualifications: None of the above 1.2 2.6 3.4 -1.8 1.5 1.5 1.8 1.4 -1.6
Financial difficulties in last 2 years 0.5 0.6 2.4 0.6 0.2 0.4 0.5 0.7 1.6
Mouth/teeth dental problems 2.1 3.2 8.8 -0.6 -1.1 -2.3 -1.8 -3.0 0.7
Heart attack 0.4 0.5 1.1 1.0 0.6 0.6 0.7 0.9 0.5
Allergy 0.7 1.5 6.1 -1.6 0.3 0.6 0.3 2.5 -0.3
Pain all over the body in last month 1.2 1.2 2.9 -0.7 1.7 0.8 1.0 0.8 -1.3
Diabetes (self-reported) 0.6 0.9 3.8 1.0 -0.0 -0.5 -0.3 0.5 -1.9
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 6.4 0.1 1.4 2.4 2.5 1.7 0.2
Medication: Ramipril 0.7 0.9 4.5 -2.1 0.1 0.3 0.7 0.3 -0.5
Medication: Simvastatin 0.3 0.4 1.5 1.2 -0.5 -0.2 0.1 0.5 -0.2
Fluid intelligence score 0.4 0.9 2.6 -0.6 0.1 -1.4 -1.6 -0.7 -0.0
Illnesses of siblings 1.0 1.4 4.1 -1.4 1.0 0.8 0.7 -0.5 -2.0
Neuroticism score 6.3 13.4 20.2 1.2 4.3 4.4 4.5 4.2 -2.0
Weight 0.1 0.4 1.0 0.2 -0.8 -0.7 -0.2 -0.5 -1.0
Impedance of arm (right) 0.0 0.2 0.7 -0.6 0.8 -0.3 -0.3 -0.0 0.3
Arm fat percentage (right) 0.3 1.1 2.3 0.2 -1.3 -1.5 -0.8 -1.1 -0.9
Trunk fat-free mass 0.1 0.3 1.7 -0.2 -0.1 0.3 0.4 0.0 -1.3
Hip circumference 0.2 1.0 1.8 0.1 -1.0 -1.2 -0.5 -1.3 -1.2
Time employed in main current job 3.0 3.5 6.1 0.2 -2.1 -2.4 -2.5 -1.8 1.1
Alcohol intake versus 10 years previously 0.9 1.4 2.8 -1.6 1.0 0.8 1.1 0.2 -1.7
Father’s age at death 1.1 1.5 5.2 2.3 -0.1 0.3 0.3 0.8 1.7
Worrier / anxious feelings 10.6 20.2 33.0 0.6 5.1 5.7 5.6 5.3 -1.7
Frequency of tiredness / lethargy in last 2 weeks 3.0 4.9 6.5 2.3 2.5 2.3 2.5 2.3 -0.9
Falls in the last year 0.4 0.6 1.1 0.6 0.0 0.7 0.7 1.0 1.1
Hair/balding pattern: Pattern 3 0.9 1.4 4.5 -2.1 1.1 1.0 0.8 0.9 0.1
Number of live births 1.4 2.0 4.3 -0.8 -0.5 -2.1 -1.6 -1.9 -0.9
Forced expiratory volume in 1-second (FEV1) 1.2 4.1 9.1 -0.5 -3.0 -1.7 -2.1 -1.3 2.4
Pulse rate 0.2 0.3 1.3 0.1 -0.2 -0.2 -0.0 -0.7 1.2
Happiness 0.3 0.3 1.4 -1.2 0.1 0.2 0.4 -0.0 0.6
Noisy workplace 0.9 1.1 2.2 0.2 0.5 1.2 1.3 1.5 -0.9
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.7 0.6 -0.5 -1.1 -1.3 -1.3 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.8 -0.3 0.2 -0.3 -0.3 -0.6 -1.3
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 0.8 -0.7 0.4 -0.2 0.6 0.6
Asthma 3.2 6.2 15.8 1.7 -2.2 -2.8 -2.3 -4.0 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.9 -0.7 0.2 -0.4 0.0 -1.7 -0.3
Medication: Cholesterol lowering 0.2 0.2 0.4 -0.4 -0.6 -0.3 -0.2 0.5 -0.6
Depression (self-reported) 2.2 2.6 5.2 -0.1 2.0 2.1 2.3 1.4 -0.0
Medication: Lansoprazole 0.5 0.5 2.5 0.3 0.1 -0.6 -0.3 -0.4 -1.6
Prospective memory result 2.6 3.1 5.1 -0.1 2.3 1.9 2.1 2.2 -0.9
Lung cancer (father) 0.4 0.5 1.7 -0.1 -0.8 -0.5 -0.5 -0.4 1.3
Illnesses of mother 0.5 0.6 2.6 -0.1 1.6 0.5 0.6 0.2 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 9.8 -0.6 -3.1 -2.0 -2.4 -1.8 1.8
Pulse wave Arterial Stiffness index 3.7 4.3 6.3 1.8 -2.0 -2.5 -2.5 -1.5 2.0
Impedance of arm (left) 0.1 0.4 1.6 -0.1 0.9 0.0 -0.0 0.2 1.3
Arm fat mass (right) 0.2 0.8 1.4 0.0 -1.1 -1.1 -0.4 -1.0 -1.2
Trunk predicted mass 0.1 0.3 1.5 -0.1 -0.1 0.3 0.4 0.1 -1.2
Standing height 0.1 0.6 1.4 -1.0 1.2 0.7 0.6 0.6 -0.4
Length of working week for main job 0.6 0.7 1.2 1.1 -0.6 -0.7 -0.7 -1.0 -0.6
Exposure to tobacco smoke at home 1.0 1.2 3.1 -1.8 1.0 0.8 0.4 0.2 -1.4
Breastfed as a baby 0.5 0.6 1.2 1.0 0.1 -0.8 -0.7 -1.1 0.4
Tense / ‘highly strung’ 3.0 5.0 9.4 0.4 2.3 2.6 2.9 3.1 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 6.1 9.3 17.7 1.0 3.6 4.2 4.2 2.1 -1.6
Hair/balding pattern: Pattern 4 0.1 0.2 0.7 0.9 0.1 0.0 0.3 0.2 -0.3
Birth weight of first child 0.2 0.4 1.1 -1.1 0.8 0.7 0.4 0.2 -0.3
Peak expiratory flow (PEF) 2.0 4.7 8.3 0.9 -2.9 -1.7 -2.2 -2.1 2.7
Pulse wave reflection index 1.8 2.2 4.6 1.5 -1.2 -1.3 -1.6 -0.8 2.1
Ever highly irritable/argumentative for 2 days 2.2 2.6 5.6 -2.3 1.2 1.3 1.3 2.4 -0.3
Loud music exposure frequency 0.2 0.2 0.5 0.7 -0.3 0.0 0.5 0.5 0.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.3 -0.4 0.2 0.5 0.2 0.3 0.3
Mouth/teeth dental problems: Bleeding gums 4.4 5.6 8.5 1.0 2.5 2.9 2.9 2.9 -1.2
Blood clot in the leg (DVT) 0.4 0.5 1.9 1.4 -0.0 0.2 0.4 -0.6 0.7
Medication: Paracetamol 0.4 0.8 2.7 1.1 -0.2 -0.6 -0.3 -0.3 1.6
Headache pain in last month 0.9 1.5 5.1 1.7 0.2 0.4 0.6 0.8 2.3
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 2.7 1.6 0.1 0.0 0.0 -1.0 1.4
Glaucoma (self-reported) 1.5 1.8 3.3 1.7 0.6 1.8 1.5 1.3 0.8
Gout (self-reported) 1.7 2.3 3.4 -1.0 1.6 1.7 1.8 1.2 -1.5
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 4.9 1.0 1.6 1.9 1.8 1.6 -2.2
Medication: Amlodipine 0.4 0.6 1.4 -0.9 -0.9 -0.6 -0.5 -1.2 0.0
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 -1.0 0.2 -0.6 -0.2 -1.1 -1.0
Birth weight 0.2 0.5 1.1 1.1 -0.3 -0.5 -0.7 -1.0 0.5
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 0.8 0.1 0.5 0.6 0.7 0.3
High blood pressure (siblings) 0.8 1.2 3.7 1.4 -0.8 -0.5 -0.7 0.4 1.9
Forced vital capacity (FVC), Best measure 0.8 3.1 6.0 -1.1 -2.5 -1.5 -1.9 -1.4 1.9
Body fat percentage 0.3 1.3 3.2 -0.2 -1.4 -1.8 -1.1 -1.1 -0.4
Leg fat percentage (right) 0.8 2.8 5.7 0.2 -2.3 -2.4 -1.8 -1.5 -0.6
Arm fat-free mass (right) 0.0 0.2 0.6 -0.4 -0.3 0.2 0.4 0.1 -0.8
Exposure to tobacco smoke outside home 0.3 0.4 1.5 1.2 -0.8 -0.2 -0.2 -0.4 -0.2
Comparative body size at age 10 1.2 3.3 8.0 0.7 -2.8 -2.1 -1.9 -1.9 0.2
Number of full brothers 1.2 1.5 2.8 1.6 -1.1 -0.6 -0.6 -1.7 1.2
Worry too long after embarrassment 3.8 6.3 13.1 1.1 2.7 2.8 2.7 3.6 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.4 6.0 -0.1 2.4 2.4 2.5 1.8 -0.5
Wheeze or whistling in the chest in last year 0.5 1.0 2.2 1.2 0.8 1.2 1.5 0.2 0.3
Number of children fathered 1.6 1.8 2.8 0.4 -1.5 -1.4 -1.7 -1.7 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.7 0.0 -0.3 0.3 0.2 0.8 0.7
Age at first live birth 0.5 0.9 1.8 0.7 -0.9 -0.8 -1.4 -0.7 1.0
Pulse wave peak to peak time 3.9 4.7 6.5 -1.8 2.2 2.5 2.6 1.7 -2.1
Health satisfaction 2.0 2.6 7.2 -2.7 1.0 1.3 1.5 1.7 -0.8
Shortness of breath walking on level ground 1.1 1.3 2.2 -0.4 1.5 1.3 1.5 1.1 -0.7
Qualifications: College or University degree 1.1 3.4 5.4 2.1 -1.5 -1.6 -2.1 -1.2 2.3
Eye problems/disorders: None of the above 1.1 1.3 2.4 -1.4 -0.4 -1.1 -1.4 -1.6 -0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 2.3 1.5 -0.1 0.6 0.6 -0.2 -0.1
Emphysema/chronic bronchitis 0.2 0.2 0.6 0.5 -0.3 0.3 0.4 -0.8 -0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 1.8 1.3 -0.7 -0.3 -0.5 -0.2 -0.0
Neck or shoulder pain in last month 2.4 3.4 5.8 -1.1 2.4 1.7 1.9 1.8 -2.0
Medication: Blood pressure 0.6 1.0 3.2 -1.8 -0.3 -0.6 -0.4 0.1 -1.4
Angina (self-reported) 0.1 0.2 0.5 0.7 0.2 0.2 0.2 0.5 -0.3
Migraine (self-reported) 0.3 0.3 0.5 -0.2 -0.2 -0.7 -0.6 -0.7 0.7
Medication: Ibuprofen 0.6 0.7 3.6 -0.2 -0.2 -0.7 -0.4 -1.9 0.2
Medication: Allopurinol 0.6 0.8 1.2 -0.7 0.6 0.9 1.1 0.8 -1.0
Medication: Omeprazole 0.4 0.5 1.5 -1.2 0.1 -0.6 -0.7 0.7 0.0
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.8 -0.1 0.5 0.3 0.1 -0.2
Mean time to correctly identify matches 2.7 5.2 10.4 0.8 2.6 2.4 2.7 3.2 0.5
Heart disease (mother) 0.1 0.1 0.2 -0.5 0.2 0.3 0.2 -0.3 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 3.0 -0.7 0.5 1.7 1.7 1.1 1.4
Whole body fat mass 0.2 0.9 1.9 -0.5 -1.2 -1.4 -0.7 -0.9 -0.7
Leg fat mass (right) 0.5 1.8 3.7 -0.2 -1.9 -1.9 -1.3 -1.2 -0.6
Arm predicted mass (right) 0.0 0.2 0.5 -0.4 -0.3 0.5 0.6 0.3 -0.7
Pulse rate, automated reading 0.8 2.6 4.1 -1.8 -1.5 -2.0 -1.8 -1.4 0.8
Alcohol intake frequency. 1.2 2.7 7.5 0.2 1.6 1.7 1.6 0.8 -2.7
Comparative height size at age 10 0.9 4.9 8.8 -0.9 2.4 3.0 2.9 2.1 -0.9
Number of full sisters 1.2 1.5 2.6 0.4 1.2 1.4 1.6 1.1 -1.1
Suffer from ‘nerves’ 1.1 1.7 4.2 -0.9 1.5 0.9 1.1 0.9 -2.0
Overall health rating 1.5 3.3 5.0 -1.1 2.0 1.8 2.2 2.2 -1.0
Chest pain or discomfort 0.4 0.5 1.7 1.3 -0.0 0.4 0.6 -0.1 0.9
Had major operations 0.6 0.7 2.3 -0.3 -1.0 -0.1 -0.4 0.9 1.5
Age at last live birth 0.2 0.2 0.5 0.3 -0.5 -0.3 -0.7 -0.4 0.6
Family relationship satisfaction 0.4 0.6 0.8 0.8 0.9 0.7 0.9 0.8 -0.0
Leg pain on walking 0.8 1.0 1.7 -1.1 -1.3 -1.2 -1.1 -0.5 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 2.0 1.4 -0.3 -0.1 -0.1 -0.6 0.1
Commuting to job workplace: Car/motor vehicle 0.6 0.6 1.4 -1.2 0.4 0.4 0.4 0.8 -1.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 1.4 1.2 -0.1 -0.1 -0.1 -0.6 -0.2
Medication: Aspirin 0.4 0.5 1.3 0.1 0.2 0.8 0.9 1.1 -0.3
Supplements: Vitamin C 0.3 0.4 1.1 -0.3 0.1 1.1 0.9 0.0 -0.2
Knee pain experienced in last month 2.2 3.5 7.8 -0.3 1.4 2.3 2.4 2.8 0.1
Hypertension (Self-reported) 0.6 1.6 4.8 -1.4 0.1 1.2 1.1 2.2 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 0.0 -0.4 -0.3 -0.4 0.5 -0.5
Illnesses of father: Heart disease 0.6 0.8 3.8 2.0 -0.7 0.2 -0.1 0.4 0.4
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.9 -0.7 -0.7 -0.4 0.2 1.0
Smoking status: Previous 0.2 0.3 1.2 -0.2 0.0 0.6 0.7 1.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 3.4 -1.8 0.9 1.4 1.5 1.5 -0.4
Whole body fat-free mass 0.0 0.3 1.5 0.0 -0.3 0.1 0.2 -0.2 -1.2
Leg fat-free mass (right) 0.0 0.2 0.8 0.4 -0.4 0.0 0.3 -0.4 -0.9
Arm fat percentage (left) 0.3 1.1 2.3 0.3 -1.4 -1.5 -0.8 -1.1 -0.5
Average weekly red wine intake 1.5 2.3 7.3 1.7 -1.5 -0.3 -0.7 -0.8 2.7
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.4 0.4 -1.4 -1.8 -1.8 -1.5 0.1
Mood swings 2.7 4.9 8.5 1.7 1.9 2.6 2.9 2.7 -0.6
Loneliness, isolation 0.8 1.0 1.9 0.5 1.4 1.1 1.4 1.0 -0.2
Long-standing illness, disability or infirmity 0.2 0.4 0.7 0.1 -0.6 -0.8 -0.6 -0.5 -0.8
Ever had bowel cancer screening 0.8 0.9 1.7 1.3 -0.8 -1.0 -0.9 -1.3 0.2
Diabetes diagnosed by doctor 0.4 0.7 2.2 1.5 -0.7 -0.6 -0.3 0.8 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.4 -0.1 -0.2 -0.1 -0.4 0.3
Friendships satisfaction 0.5 0.6 1.5 0.8 1.2 0.6 0.8 0.9 -0.2
Qualifications: nursing, teaching 1.1 1.7 7.2 2.7 -0.8 -0.8 -0.9 -0.8 0.7
Commuting to job workplace: Walk 0.3 0.3 0.7 0.8 0.1 0.6 0.4 0.2 0.7
Eye problems/disorders: Cataract 1.0 1.1 2.4 1.6 0.3 0.9 1.1 1.2 0.8
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.5 0.6 1.6 1.6 1.6 2.1 -0.8
Medication for cholesterol 0.3 0.4 1.2 -1.1 0.6 0.2 0.2 -0.1 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.6 1.3 0.5 0.5 0.6 -0.2 -0.3
Back pain experienced in last month 1.4 2.0 3.5 0.9 0.9 1.5 1.6 1.9 1.4
Mineral and other dietary supplements 0.4 0.5 0.8 -0.6 -0.4 -0.9 -0.6 -0.8 0.8
Breast cancer (self-reported) 2.0 2.5 4.1 0.3 1.4 1.9 1.9 2.0 1.2
Asthma (self-reported) 3.2 6.3 16.0 1.6 -2.1 -2.9 -2.5 -4.0 0.6
Osteoporosis (self-reported) 2.1 2.6 5.1 1.0 1.4 2.3 2.2 1.3 -1.1
Osteoarthritis (self-reported) 2.1 2.7 4.8 -0.3 1.8 1.9 2.2 2.0 -0.7
Medication: Aspirin 0.3 0.3 0.8 0.0 -0.0 0.5 0.8 0.9 -0.5
Medication: Gliclazide 0.3 0.4 1.5 0.8 0.5 -0.2 -0.0 -0.1 -1.2
Illnesses of father: None of the above (group 1) 0.1 0.1 0.4 -0.6 0.4 -0.2 0.0 -0.5 0.1
Smoking status: Current 0.5 0.8 3.9 0.5 0.3 0.3 0.5 0.7 2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.0 8.6 18.9 -0.5 -4.4 -3.0 -3.4 -1.9 2.9
Whole body water mass 0.1 0.3 1.6 -0.0 -0.2 0.3 0.5 -0.0 -1.2
Leg predicted mass (right) 0.0 0.2 0.9 0.4 -0.3 -0.0 0.2 -0.5 -0.9
Arm fat mass (left) 0.1 0.6 1.0 0.3 -0.9 -1.0 -0.3 -0.9 -1.0
Number of self-reported non-cancer illnesses 0.6 1.1 2.3 1.0 0.6 1.4 1.5 1.0 0.2
Average weekly champagne plus white wine intake 3.6 5.0 9.2 -0.1 -2.5 -3.0 -3.0 -2.3 0.7
Miserableness 2.9 5.1 10.7 0.3 3.3 2.1 2.6 2.0 -2.2
Guilty feelings 4.7 7.1 14.4 -0.2 2.5 3.2 3.1 3.8 -1.6
Wears glasses or contact lenses 1.8 2.1 6.6 2.6 1.2 1.2 1.1 1.5 -0.1
Ever taken oral contraceptive pill 0.7 0.8 1.5 -0.1 -1.2 -1.0 -0.8 -1.2 0.2
Hearing aid user 0.7 0.8 1.2 0.4 1.1 1.0 1.1 1.0 -0.6
Mother’s age at death 1.1 1.3 2.5 0.5 -0.8 -1.4 -1.6 -1.5 0.5
Financial situation satisfaction 0.7 0.9 2.0 -0.5 0.8 1.2 1.4 1.0 -0.3
Tinnitus: Yes, now most or all of the time 1.0 1.2 5.1 2.3 -0.1 -0.1 0.0 1.1 0.8
Commuting to job workplace: Public transport 0.6 0.7 2.7 -1.7 0.1 -0.8 -0.7 -0.7 -0.0
Eye problems/disorders: Glaucoma 1.7 2.0 7.8 2.8 0.1 1.2 1.1 1.1 0.4
Medication: Blood pressure 0.0 0.1 0.4 0.2 0.0 0.1 0.1 0.6 -0.0
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.7 -1.6 1.3 1.0 1.2 1.0 -0.9
Supplements: Fish oil (including cod liver oil) 1.4 1.9 3.7 0.3 1.4 1.9 1.7 1.4 -0.8
High cholesterol (Self-reported) 1.4 2.5 5.3 0.8 1.5 1.7 1.9 2.3 -0.7
Medication: Bendroflumethiazide 0.3 0.4 1.9 -0.1 0.5 -0.1 0.1 1.4 -0.4
Medication: Paracetamol 1.0 1.6 4.0 1.4 -1.2 -1.2 -0.8 -0.4 2.0
Medication: Lisinopril 1.0 1.3 2.2 -1.5 -0.6 -1.2 -1.4 -0.7 -1.1
Medication: Atorvastatin 0.7 0.8 2.0 -0.4 1.4 0.7 1.0 1.1 -0.0
Illnesses of father: High blood pressure 2.2 2.7 4.9 -0.2 2.0 1.9 1.5 2.2 -1.3
Alcohol drinker status: Never 0.1 0.1 0.2 -0.4 0.0 0.5 0.3 -0.0 -0.3
Ever smoked 1.2 2.2 4.8 0.2 1.0 1.7 1.9 2.2 1.0
Basal metabolic rate 0.1 0.3 1.5 -0.0 -0.4 -0.1 0.2 -0.3 -1.2
Leg fat percentage (left) 0.6 2.2 4.7 0.4 -2.0 -2.2 -1.5 -1.4 -0.6
Arm fat-free mass (left) 0.1 0.6 2.4 -0.2 0.0 0.5 0.7 0.3 -1.6
Number of operations (self-reported) 1.3 1.9 4.1 -2.0 -1.6 -1.3 -1.2 -0.0 1.3
Average weekly beer plus cider intake 0.6 0.8 1.8 0.4 1.3 1.0 1.3 0.4 -0.5
Irritability 3.4 5.8 10.2 1.8 2.6 3.0 3.2 2.4 -0.1
Risk taking 0.3 0.4 1.8 1.3 0.1 -0.3 -0.3 0.3 0.6
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.9 -0.9 -0.6 -0.3 -0.5 -0.1 0.3
Fractured/broken bones in last 5 years 0.1 0.1 0.5 -0.7 -0.2 0.3 0.1 0.1 0.1
Age started oral contraceptive pill 0.6 0.7 2.9 0.8 0.3 -0.3 -0.3 0.8 1.7
Diastolic blood pressure, automated reading 0.9 2.9 6.8 -2.6 -2.0 -1.7 -1.7 -0.7 0.1
Ever depressed for a whole week 0.8 1.0 2.1 0.6 0.5 1.4 1.1 1.5 0.3
Unable to work because of sickness or disability 0.5 0.7 0.9 -0.7 0.9 0.7 0.9 0.9 -0.8
Commuting to job workplace: Cycle 0.2 0.3 1.0 0.1 0.3 -0.4 -0.6 -0.2 -1.0
Myopia 0.2 0.3 1.0 0.3 0.3 -0.5 -0.7 -0.2 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.9 1.2 0.2 -0.4 -0.5 -1.7 -0.4
Cholesterol lowering medication 1.1 1.6 5.3 2.3 1.0 0.9 1.1 0.9 0.7
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.7 -0.4 0.7 -0.0 -0.1 0.9 -0.4
Pain experienced in last month 1.3 2.3 4.0 -0.3 -1.5 -1.6 -2.0 -2.0 -1.0
Supplements: Calcium 0.4 0.4 1.6 -0.1 -0.8 0.0 -0.0 0.6 1.3
Basal cell carcinoma (self-reported) 0.4 0.5 2.2 1.5 -0.3 0.1 0.1 0.5 -0.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 0.7 0.6 0.6 0.6 0.9 0.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.2 1.5 -0.1 -0.1 0.2 -1.0 0.6
Heart disease (siblings) 1.2 1.5 3.5 -1.9 -1.4 -1.0 -0.9 -1.4 -0.4
Alcohol drinker status: Previous 2.4 2.8 4.2 2.0 -1.8 -1.9 -1.9 -1.3 0.5
Pack years of smoking 1.9 2.8 4.4 -0.1 1.8 1.7 2.1 2.0 -1.6
Impedance of whole body 0.1 0.6 1.8 -0.9 0.5 -0.5 -0.6 0.1 1.4
Leg fat mass (left) 0.4 1.4 3.0 -0.1 -1.7 -1.7 -1.1 -1.1 -0.6
Arm predicted mass (left) 0.1 0.5 2.3 -0.4 -0.0 0.3 0.6 0.2 -1.5