Hub : Genes

ISOC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2694	0.1140	8.5e-03	0.021	NA	0.050	NA	0.047	6.0e-02	NA	6.9e-03	NA	8.7e-03
2	GTEx	Heart Atrial Appendage	0.1430	0.0570	1.5e-03	0.013	NA	0.027	NA	0.029	8.1e-02	NA	2.2e-02	NA	1.8e-02
3	GTEx	Lung	0.0691	0.0320	7.1e-03	0.039	NA	0.011	NA	0.008	5.5e-04	NA	4.2e-02	NA	7.7e-02
4	GTEx	Skin Sun Exposed Lower leg	0.0730	0.0360	5.6e-03	0.012	NA	-0.003	NA	0.001	3.3e-02	NA	6.3e-01	NA	2.4e-01
5	GTEx	Testis	0.2780	0.0620	8.8e-11	0.212	NA	0.232	NA	0.247	8.4e-10	NA	1.2e-10	NA	2.6e-11
6	ROSMAP	Brain Pre-frontal Cortex	0.0506	0.0252	1.0e-02	0.000	0.011	0.008	0.014	0.000	2.8e-01	1.3e-02	2.6e-02	5.4e-03	2.9e-01
7	YFS	Blood	0.2439	0.0329	0.0e+00	0.219	0.274	0.288	0.242	0.282	5.4e-70	7.7e-90	2.4e-95	4.3e-78	4.9e-93

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.3	-0.4	-0.5	-0.3	-0.9	-0.6	-1.1	0.6
Bipolar Disorder or Schizophrenia	0.3	0.6	1.1	0.5	-1.1	-0.5	-1.0	-0.5	-1.0	0.8
Depressed Affect (Nagel 2018)	0.3	0.7	2.7	-1.0	-0.5	0.6	-0.6	-0.2	-1.6	-0.3
Depression (Nagel 2018)	0.7	1.0	5.7	-0.4	0.1	2.4	0.9	0.4	0.4	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.6	1.3	-0.9	-0.9	-0.8	-1.0	0.4	1.0
Neuroticism (Nagel 2018)	0.2	0.5	2.3	-0.1	-0.0	1.5	0.1	0.1	-1.0	0.2
Schizophrenia (2018)	0.2	0.4	0.9	1.0	-1.0	-0.1	-0.6	-0.1	-0.4	0.5
Schizophrenia vs Biploar Disorder	1.1	1.5	3.8	-0.2	1.7	1.9	1.0	0.9	-0.9	-1.0
Worry (Nagel 2018)	0.6	1.2	3.4	-0.6	0.2	1.7	0.3	-0.5	-1.2	1.8
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.6	-0.5	-0.2	-0.9	0.3	0.2	-0.7
Alzheimer’s Disease (in father)	1.6	1.7	4.3	-0.8	-0.5	-0.9	1.2	-1.1	-1.9	2.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	-1.2	-0.6	-0.5	0.2	-0.4	-1.1	0.6
Crohns Disease (2017)	0.2	0.4	1.1	0.2	0.5	0.0	-0.1	-0.6	-1.1	1.0
Irritable Bowel Disease (IBD)	0.4	0.9	2.4	-0.6	1.4	0.8	0.3	0.9	-1.6	0.0
Ulcerative Colitis (UC)	1.7	3.3	5.9	-1.7	2.3	1.8	1.2	2.4	-1.8	-1.1
Major Depression (MDD)	0.6	0.7	2.0	-0.8	1.1	-0.2	1.4	0.1	1.0	-0.4
Reaction Time	0.3	0.6	2.2	1.1	-0.6	0.7	-0.3	-0.2	1.5	0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.6	2.1	-1.2	-1.4	-0.9	-1.9	-0.2	1.8
Breast Cancer	1.0	2.4	6.8	0.5	-2.6	-2.5	-1.7	-0.5	-0.4	0.2
Ovarian Cancer	0.4	0.5	1.4	-1.2	-0.8	0.1	1.2	-0.1	0.2	-0.6
Prostate Cancer	0.2	0.3	1.0	0.0	-0.3	0.2	-0.6	-0.3	-1.0	0.6
Age at First Birth	0.3	0.4	1.6	0.7	-0.2	-0.2	-0.5	0.9	-0.0	-1.3
Bipolar Disorder (2011)	0.3	0.3	0.7	0.4	-0.1	0.5	-0.9	0.1	-0.2	-0.7
Body Mass Index (BMI) (2010)	0.6	0.9	2.3	1.5	0.5	-1.0	-1.4	-0.7	-0.4	-0.0
Coronary Artery Disease (CAD)	0.5	0.5	1.4	-0.3	-0.7	-0.8	-1.2	0.2	-1.1	0.3
Crohns Disease (2012)	0.3	0.5	1.7	0.2	0.2	0.6	0.0	-0.9	0.9	1.3
Mean Putamen Volume	0.5	0.6	1.8	0.6	0.3	0.6	-0.7	-0.7	1.3	0.6
Fasting Glucose	0.7	0.8	2.7	-1.6	1.0	-1.0	-0.1	0.4	1.0	-0.1
HbA1C	0.5	0.5	1.8	-0.7	0.3	-0.8	0.2	-0.7	1.4	-0.1
HDL Cholesterol	2.2	3.7	5.1	-2.0	1.3	2.2	2.3	2.1	1.6	-1.8
LDL Cholesterol	0.1	0.2	0.6	0.7	0.3	-0.0	0.0	-0.8	0.1	0.4
Lupus	0.5	0.7	1.7	-0.5	0.9	-0.7	-1.2	0.2	-1.3	0.1
Neuroticism (2016)	0.2	0.3	0.7	-0.8	-0.8	0.5	0.2	-0.1	-0.3	0.4
Primary Biliary Cirrhosis	0.9	1.4	2.9	0.6	1.5	0.6	-0.6	0.8	-1.7	-1.6
Rheumatoid Arthritis	2.7	3.7	7.1	0.4	1.1	2.7	2.5	2.4	0.7	-2.1
Schizophrenia (2014)	0.4	0.9	1.9	0.4	-1.4	-0.8	-0.9	-1.1	-0.2	1.3
Triglycerides	0.6	1.0	1.5	0.1	-1.2	-1.1	-1.1	-1.2	-1.2	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.5	-1.6	0.2	0.8	-0.4	1.4	-0.9	-1.4
Ulcerative Colitis	2.3	3.3	6.8	-1.2	2.6	1.7	-0.1	2.1	-2.6	-1.0
Blood Eosinophil Count	0.2	1.3	6.4	-1.4	0.2	-0.2	-0.7	-0.4	-2.5	0.3
Blood Platelet Count	0.4	4.3	14.9	0.8	-0.0	-0.6	0.9	-2.6	2.7	3.9
Blood Red Count	0.2	2.1	8.6	0.3	0.8	-1.8	1.0	-0.9	2.9	0.5
Blood White Count	0.5	3.3	6.2	0.9	-2.0	-2.2	-0.9	-2.5	2.0	1.5
Heel T-Score	1.0	8.1	20.4	-0.0	-2.9	-3.0	-2.2	-3.4	4.5	1.4
BMI	0.2	1.1	6.9	0.1	-0.1	-0.3	-0.0	-0.8	2.6	-0.2
Height	0.1	1.1	2.8	-1.7	-1.6	-1.4	0.1	0.4	-0.7	-0.0
Waist Hip Ratio (WHR)	0.6	2.5	8.6	1.3	-1.0	0.3	-0.5	-1.7	1.8	2.9
Systolic Blood Pressure	0.6	3.1	7.9	-1.3	-2.8	-2.8	-0.1	-0.4	-1.9	-0.6
Smoking Status	0.2	0.4	1.6	1.3	0.7	0.5	0.3	0.5	-0.3	-0.7
Allergy or Eczema	0.5	1.3	7.2	-2.7	1.1	-0.2	0.7	-0.1	0.1	0.3
Cardiovascular Disease	1.3	4.5	13.4	-0.3	-2.6	-3.7	-1.6	-2.0	-1.8	1.3
Hypothyroidism (self reported)	0.4	0.9	2.7	-1.2	-0.9	-0.8	-1.7	0.0	-0.3	-0.6
Respiratory disease	0.4	0.9	5.2	-2.3	0.7	-0.2	0.5	0.3	-0.5	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.9	-0.2	0.2	0.1	0.5	-0.8	-0.2	1.7
Lung FEV1/FVC ratio	1.1	5.6	15.5	-0.3	3.1	1.3	2.1	2.8	-0.3	-3.9
Lung FVC	0.4	2.2	4.7	1.1	2.1	2.0	0.7	0.2	-2.2	0.8
Neuroticism	0.4	0.9	2.4	-0.5	-0.5	0.7	-0.3	-1.3	-1.2	1.6
Chronotype (morning person)	1.2	2.8	11.4	0.7	0.0	0.9	2.4	0.9	3.4	-0.4
Hair Pigment	0.1	3.7	6.6	1.1	-1.4	-2.0	-2.6	-2.5	1.1	2.0
Tanning	0.1	0.9	2.4	0.6	-0.8	-1.5	-0.5	-0.8	1.2	0.8
Hand grip strength (left)	1.0	2.6	6.1	-0.4	1.3	2.3	2.5	1.4	1.6	0.1
Number of treatments/medications taken	0.9	1.7	4.7	-1.9	-0.3	-1.5	0.1	-0.5	-2.2	0.8
Average weekly spirits intake	0.8	1.0	2.4	-1.0	0.4	-1.4	0.6	-0.8	-0.2	1.5
Sensitivity / hurt feelings	0.9	1.5	4.6	-0.1	1.2	2.1	0.7	1.3	-0.7	-1.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	7.0	-0.4	0.6	2.7	0.9	0.7	-0.4	0.3
Hearing difficulty/problems: Yes	0.6	0.9	2.0	-0.1	-1.4	-1.2	-1.4	-0.5	-0.7	-0.8
Relative age of first facial hair	0.3	0.6	1.9	-1.4	-0.4	-1.2	-0.1	-0.3	0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.1	-1.4	-0.5	-0.8	-0.5	-0.3	-0.5	0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	-1.3	-0.5	-1.0	-0.6	-0.4	1.2	-0.7
Ever had hysterectomy (womb removed)	0.9	1.0	3.0	-1.7	-1.0	-1.1	-0.4	-0.4	-1.1	0.7
Systolic blood pressure, automated reading	0.4	1.2	4.1	-1.1	-2.0	-1.6	0.2	-0.1	0.9	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.8	0.3	0.2	-0.2	0.9	0.3	-0.9	-0.0
Angina	1.3	1.8	3.1	-1.7	-1.8	-1.8	-1.0	-1.2	0.1	0.9
Medication for hormone replacement therapy	0.3	0.3	1.4	-0.2	-0.1	0.1	0.6	-0.6	1.2	0.3
Vitamin and mineral supplements	1.0	1.4	3.8	1.6	-2.0	-1.1	-0.9	-0.9	0.6	-0.3
Supplements: Zinc	0.3	0.4	0.7	0.5	-0.4	0.4	-0.8	0.6	-0.6	-0.7
Medication: Co-codamol	0.0	0.1	0.3	-0.0	0.1	-0.1	-0.2	-0.1	-0.2	0.5
Medication: Metformin	0.4	0.6	1.1	-1.0	0.7	0.4	1.0	0.0	-0.6	0.9
Diabetes (father)	1.5	1.9	5.7	-0.1	-0.6	-2.4	-2.0	-1.2	-0.6	1.0
Diabetes (mother)	2.1	2.7	6.8	-1.1	-1.5	-2.6	-1.3	-1.9	0.4	1.7
Severe depression (siblings)	1.8	2.0	3.7	-1.5	1.6	1.1	1.1	1.6	-0.6	-1.9
Pack years adult smoking proportion	0.5	0.8	2.1	-0.1	1.2	0.9	1.0	-0.3	0.2	1.4
Impedance of leg (right)	0.5	2.4	6.5	0.6	-2.5	-1.2	-1.7	-0.2	-2.3	0.8
Leg fat-free mass (left)	0.2	1.0	5.3	0.2	0.4	-0.4	0.1	-1.0	2.3	0.3
Trunk fat percentage	2.0	7.9	15.0	0.6	-3.1	-3.3	-2.6	-3.9	2.2	2.7
Hand grip strength (right)	0.4	1.1	2.4	0.8	1.3	1.5	0.9	0.6	1.3	0.5
Townsend deprivation index at recruitment	2.7	3.9	8.2	0.2	-2.2	-2.9	-2.5	-2.2	1.2	1.2
Current tobacco smoking	0.8	1.3	3.4	-0.1	1.4	1.8	1.2	1.1	-0.4	-1.0
Average weekly fortified wine intake	0.3	0.3	0.9	-0.0	-0.1	0.2	0.6	0.9	-0.9	-0.5
Maternal smoking around birth	0.6	0.8	3.0	0.7	-1.7	-0.7	-0.8	-1.0	0.2	0.2
Fed-up feelings	0.7	1.3	3.9	-1.1	-0.4	0.3	-0.6	-1.3	-1.3	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-1.5	-1.0	0.2	0.4	-0.3	0.8	0.7
Relative age voice broke	0.6	0.9	2.8	-1.4	0.5	0.2	0.1	1.0	-0.3	-1.7
Taking other prescription medications	1.4	2.1	4.0	-1.2	-1.3	-1.9	-1.0	-1.7	-0.5	2.0
Age when periods started (menarche)	0.5	1.1	2.4	1.2	0.6	1.1	0.4	1.2	-0.8	-1.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.7	-1.4	-0.2	-0.4	0.6	0.8	-1.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.9	-0.7	-1.3	-1.8	0.3	-1.6	2.0	0.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.1	1.8	-0.0	-0.9	-1.1	-1.5	0.3	1.2
Qualifications: CSEs or equivalent	1.0	1.3	5.9	-0.3	0.8	0.7	1.1	0.7	2.4	-0.4
Serious illness, injury or assault to yourself	0.4	0.5	2.1	0.9	-0.1	-0.0	-0.7	-0.6	-1.4	0.2
High blood pressure	1.5	4.3	15.8	-1.3	-2.5	-4.0	-1.0	-1.8	-0.0	1.5
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.7	-1.5	1.2	1.3	1.6	0.0	0.2	1.0
Multivitamins +/- minerals	0.7	0.8	1.9	-1.0	1.4	0.7	0.9	0.2	-1.1	0.7
Stomach or abdominal pain in last month	1.1	1.4	3.8	0.6	-0.8	-0.7	-0.9	-1.8	0.4	2.0
Supplements: Glucosamine	0.5	0.6	1.5	-0.5	1.2	0.0	0.8	0.7	-1.0	-0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.1	-1.5	-0.3	-0.4	0.4	-0.7	-0.3	0.7
Medication: Atenolol	2.3	2.8	6.2	-0.5	-2.1	-2.5	-0.5	-1.8	0.4	2.3
Medication: Levothyroxine sodium	0.4	0.7	2.6	-0.9	-0.3	0.2	0.5	0.6	1.6	-0.7
Sitting height	0.1	0.9	2.6	-0.2	-1.6	-0.9	-0.6	-1.1	-1.1	0.4
Chronic bronchitis/emphysema (father)	1.8	2.1	3.4	1.8	-1.4	-1.4	-1.5	-1.4	1.8	-0.3
High blood pressure (mother)	1.1	1.5	3.6	-0.1	-1.7	-1.9	-1.2	-0.4	-1.4	-0.7
Body mass index (BMI)	0.8	3.4	7.9	0.4	-1.1	-2.1	-1.8	-2.5	2.8	0.7
Impedance of leg (left)	0.5	2.2	6.9	-0.1	-2.4	-0.9	-1.2	0.0	-2.6	0.9
Leg predicted mass (left)	0.2	0.9	5.2	0.1	0.3	-0.5	0.0	-1.0	2.3	0.2
Trunk fat mass	1.5	6.2	11.4	0.2	-2.6	-3.1	-2.2	-3.4	2.5	2.2
Waist circumference	0.6	2.0	5.4	0.3	-0.9	-1.3	-1.1	-1.9	2.3	1.2
Number of incorrect matches in round	1.1	1.9	4.6	-2.1	1.6	1.2	0.6	1.4	1.1	-1.0
Past tobacco smoking	0.9	1.7	4.5	-1.2	2.1	1.6	0.9	1.3	-0.8	0.0
Alcohol usually taken with meals	0.1	0.2	0.5	0.4	-0.4	0.1	0.1	0.1	-0.7	0.5
Nervous feelings	0.8	1.5	4.7	-0.1	0.0	1.1	0.3	-0.6	-2.0	2.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	-1.3	0.8	0.8	0.4	0.9	-1.5	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.8	-0.1	-1.0	-1.0	-1.3	-0.2	-0.0	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.0	0.8	0.2	1.4	0.6	1.4	-1.2	-0.8
Had menopause	1.8	2.3	5.9	-1.6	1.8	0.2	1.1	1.6	0.4	-2.4
Had other major operations	1.9	2.3	8.5	-1.0	1.5	1.8	2.9	1.1	0.2	-0.3
Forced vital capacity (FVC)	0.2	0.7	1.9	1.4	0.4	0.8	0.3	-0.5	-0.5	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	6.8	-0.9	-1.1	-1.2	1.0	-1.3	2.6	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	-0.3	-0.9	0.8	0.0	0.6	0.7	-0.7
Qualifications: None of the above	1.2	2.5	6.8	-2.6	-2.0	-1.9	-1.0	-0.4	1.2	-0.8
Financial difficulties in last 2 years	0.3	0.4	1.4	0.7	-0.3	1.2	0.7	-0.5	0.6	0.2
Mouth/teeth dental problems	0.3	0.5	1.9	0.2	-0.4	0.7	0.8	-0.6	0.1	1.4
Heart attack	0.8	1.0	1.8	-1.2	-1.3	-0.9	-1.2	-0.2	-1.2	0.2
Allergy	1.1	2.5	6.9	2.6	-2.1	-1.5	-1.8	-1.1	0.2	-0.1
Pain all over the body in last month	2.4	2.5	8.7	-0.1	0.8	2.9	1.7	1.9	0.1	-1.3
Diabetes (self-reported)	0.7	1.1	3.8	-0.5	-0.5	-0.9	-0.1	-1.5	-0.8	2.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	3.4	-1.8	1.2	-0.0	0.5	0.2	0.4	0.2
Medication: Ramipril	3.4	4.4	11.2	1.5	-3.3	-2.0	-2.5	-2.2	-1.0	1.2
Medication: Simvastatin	0.6	0.9	2.4	-1.2	-0.6	-0.2	0.1	-0.9	-1.2	1.6
Fluid intelligence score	0.5	1.0	3.2	1.8	-1.2	-0.6	0.2	-1.0	0.5	0.9
Illnesses of siblings	1.6	2.3	5.3	0.2	2.0	2.3	1.7	1.6	-0.4	-1.2
Neuroticism score	0.7	1.5	4.4	-1.3	0.7	1.7	0.7	0.3	-2.1	0.4
Weight	0.5	2.3	5.2	0.1	-1.2	-1.9	-1.1	-2.0	2.3	0.7
Impedance of arm (right)	0.7	3.2	9.2	2.1	-2.5	0.6	0.3	-1.3	-0.2	3.0
Arm fat percentage (right)	1.8	6.9	13.8	0.7	-2.7	-2.4	-2.3	-3.7	3.1	2.6
Trunk fat-free mass	0.1	0.7	1.6	-1.1	0.3	-0.6	0.1	0.4	1.3	-1.1
Hip circumference	0.2	0.9	2.5	-0.1	-0.6	-1.6	-1.3	-1.0	0.5	-0.4
Time employed in main current job	1.8	2.1	4.2	2.0	-1.8	-0.9	-1.4	-1.2	1.5	1.1
Alcohol intake versus 10 years previously	0.2	0.2	1.2	0.3	-0.0	0.1	0.5	0.5	0.1	-1.1
Father’s age at death	0.4	0.5	1.5	1.2	-1.2	0.2	0.4	-0.2	0.4	0.0
Worrier / anxious feelings	0.6	1.2	2.8	-1.6	0.3	0.7	-0.6	-0.4	-1.7	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	-0.8	0.6	0.8	-0.2	0.0	-0.6	-0.1
Falls in the last year	0.8	1.0	1.8	1.3	-0.8	-1.1	-1.3	-1.1	-0.0	0.7
Hair/balding pattern: Pattern 3	0.8	1.2	4.7	-2.2	0.2	-0.8	-0.5	-0.7	-1.2	0.8
Number of live births	0.1	0.2	0.7	0.4	-0.2	-0.0	0.8	0.1	0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.7	1.2	1.2	1.6	1.3	0.7	-0.4	-0.0
Pulse rate	0.7	1.1	2.4	-0.9	1.4	-0.8	-0.5	-1.1	-0.9	1.6
Happiness	0.5	0.6	2.4	-1.5	0.5	0.9	0.4	0.2	-0.4	0.4
Noisy workplace	1.4	1.7	5.2	0.0	-1.5	-1.6	-2.3	-0.5	0.9	-1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	0.2	-1.2	0.1	-0.7	-0.8	-0.3	1.4
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.5	0.2	1.6	2.9	0.5	1.2	-1.2	-1.2
Mouth/teeth dental problems: Dentures	0.9	1.6	4.4	-1.8	0.2	-1.0	-0.0	1.4	-0.6	-2.1
Asthma	0.6	1.1	3.7	-1.9	0.3	0.5	0.6	0.4	-1.8	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.4	0.8	-0.1	-0.8	-0.1	-1.1	-0.5
Medication: Cholesterol lowering	1.1	1.7	3.4	-1.0	-0.9	-1.5	-0.8	-1.5	-1.2	1.9
Depression (self-reported)	0.4	0.5	1.7	-0.0	-1.3	-0.2	0.7	-0.9	0.2	0.5
Medication: Lansoprazole	0.5	0.6	1.7	-0.0	-1.3	-0.5	0.2	-0.9	-0.6	1.0
Prospective memory result	0.3	0.3	1.2	0.5	-1.1	0.4	-0.7	-0.2	-0.3	-0.1
Lung cancer (father)	1.1	1.3	2.1	-1.2	1.4	0.6	1.2	0.9	1.1	-1.4
Illnesses of mother	1.3	1.6	5.2	0.3	1.4	1.9	0.7	-0.3	0.1	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.1	1.5	0.5	1.2	0.6	-0.2	-0.5	0.6
Pulse wave Arterial Stiffness index	1.0	1.2	3.7	-1.9	1.5	0.3	-0.4	0.7	-1.0	-0.8
Impedance of arm (left)	0.9	3.9	12.6	2.0	-2.8	-0.1	-0.1	-1.8	-0.1	3.5
Arm fat mass (right)	1.3	5.3	9.9	0.4	-2.1	-2.5	-2.2	-3.1	2.9	1.7
Trunk predicted mass	0.1	0.7	1.9	-1.1	0.3	-0.5	0.1	0.4	1.4	-1.1
Standing height	0.1	0.5	1.3	-0.7	-0.8	-0.0	1.2	0.7	-0.9	0.2
Length of working week for main job	0.2	0.2	0.4	0.3	-0.7	-0.6	0.0	0.3	0.4	-0.6
Exposure to tobacco smoke at home	3.2	3.6	9.3	0.6	-1.0	-3.1	-3.0	-2.1	1.0	0.4
Breastfed as a baby	1.6	2.0	6.0	0.1	0.9	-1.4	-0.6	-2.1	0.5	2.5
Tense / ‘highly strung’	1.2	2.0	5.4	-1.6	0.6	1.8	1.1	1.3	-2.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.7	-0.4	-1.9	-1.8	-1.9	-1.1	-0.1	-0.2
Hair/balding pattern: Pattern 4	0.6	1.4	3.4	-0.4	1.8	0.8	-0.2	1.4	-0.7	-1.8
Birth weight of first child	0.5	0.8	2.7	0.4	0.8	1.6	0.0	-0.1	0.9	1.2
Peak expiratory flow (PEF)	0.2	0.5	1.3	0.7	-1.2	0.9	0.5	0.4	0.3	0.0
Pulse wave reflection index	0.7	0.9	3.8	-0.8	-0.2	-0.7	-0.1	-1.1	2.0	0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.6	0.6	0.9	0.5	1.1	0.8	-0.6
Loud music exposure frequency	1.8	2.0	6.4	1.5	-1.4	-0.5	0.2	-1.3	1.2	2.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.5	-0.4	1.1	1.6	1.3	0.5	-1.1	0.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.0	1.7	1.4	1.6	1.7	1.0	1.4	-1.2
Blood clot in the leg (DVT)	0.7	1.0	2.3	-1.5	1.2	0.8	0.9	0.9	-0.7	0.1
Medication: Paracetamol	0.2	0.4	1.2	0.2	0.2	-0.8	-0.3	-0.9	1.1	0.2
Headache pain in last month	1.0	1.7	4.2	1.5	-1.3	0.2	-0.5	-1.9	0.2	2.1
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	6.9	0.1	1.8	2.6	1.2	2.0	2.5	-2.4
Glaucoma (self-reported)	0.8	0.9	2.7	-0.9	-1.1	-0.6	-0.9	-0.4	-1.6	0.5
Gout (self-reported)	0.8	1.1	2.7	-1.1	-1.6	-1.5	-0.1	-0.7	-0.6	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.4	-0.4	-1.2	-0.7	-0.9	0.3	0.6	-0.5
Medication: Amlodipine	2.8	4.0	12.5	-1.2	-2.1	-3.5	-0.2	-2.1	-0.9	2.0
Medication: Ventolin 100micrograms inhaler	1.4	1.9	9.4	-1.0	-0.6	0.0	-1.4	-0.5	-3.1	-0.3
Birth weight	0.2	0.5	2.4	1.5	-0.9	0.7	-0.1	-0.2	-0.2	0.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.1	-0.1	0.4	0.3	1.2	1.4	0.4	-1.8
High blood pressure (siblings)	0.6	0.8	2.4	-0.1	-1.4	-1.5	-1.0	-0.5	0.5	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.1	1.3	-0.1	0.8	0.0	-0.8	-0.6	1.4
Body fat percentage	2.0	7.8	14.3	0.5	-3.0	-3.4	-2.9	-3.8	2.3	2.4
Leg fat percentage (right)	1.9	6.8	12.7	0.4	-2.6	-3.5	-3.6	-3.2	2.0	1.1
Arm fat-free mass (right)	0.2	1.0	2.6	-1.1	0.2	-1.6	-1.1	-0.4	1.1	-0.9
Exposure to tobacco smoke outside home	0.8	1.0	2.0	-1.3	0.1	-1.4	-1.4	-0.9	0.8	0.3
Comparative body size at age 10	0.9	2.5	4.6	0.1	-1.6	-1.1	-1.1	-2.2	2.1	1.8
Number of full brothers	0.4	0.6	2.0	1.4	-0.5	0.8	0.4	0.2	-0.8	-0.5
Worry too long after embarrassment	0.2	0.4	1.0	0.9	0.6	1.0	0.2	0.1	-0.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.1	-1.0	-0.1	-0.4	0.5	-0.4	-0.8
Wheeze or whistling in the chest in last year	0.8	1.3	3.7	-1.9	0.9	-0.4	0.3	0.7	-1.8	-1.0
Number of children fathered	1.0	1.1	2.5	0.5	1.2	1.6	1.2	1.1	0.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-1.7	0.2	-0.1	-0.4	0.2	-0.9	-1.3
Age at first live birth	0.3	0.6	2.2	0.4	0.5	-0.4	-0.7	-0.8	-0.4	1.5
Pulse wave peak to peak time	1.1	1.4	4.3	2.1	-1.6	-0.2	0.4	-0.7	1.1	0.8
Health satisfaction	0.4	0.6	2.7	-0.7	0.0	0.4	-0.5	0.4	-1.6	-0.6
Shortness of breath walking on level ground	0.9	1.1	2.9	-1.7	0.2	-0.7	-0.9	0.9	-1.1	-1.1
Qualifications: College or University degree	1.0	3.0	18.1	0.2	1.0	1.1	0.2	0.4	-4.2	0.8
Eye problems/disorders: None of the above	0.6	0.7	2.5	0.9	0.5	1.3	0.3	0.1	1.6	-0.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.0	0.5	1.4	0.6	0.8	0.9	-0.9	-1.4
Emphysema/chronic bronchitis	1.2	1.3	3.3	-1.8	1.6	0.9	0.1	0.9	1.2	-0.5
Medication for pain relief, constipation, heartburn	0.7	1.2	2.6	0.4	1.0	1.6	0.8	1.3	-0.6	-1.3
Neck or shoulder pain in last month	2.5	3.6	7.3	1.1	-1.8	-2.1	-2.7	-2.4	-1.2	1.4
Medication: Blood pressure	2.0	3.5	8.5	-0.1	-2.5	-2.9	-0.5	-1.7	-1.6	1.9
Angina (self-reported)	1.2	1.6	3.3	-1.6	-1.8	-1.8	-0.9	-1.2	0.0	0.7
Migraine (self-reported)	1.3	1.6	5.0	-0.2	0.1	1.2	2.2	0.3	-2.1	0.2
Medication: Ibuprofen	1.0	1.1	4.6	0.7	0.6	-0.9	-2.1	-0.7	-1.1	-0.2
Medication: Allopurinol	0.8	1.0	3.9	-1.3	-0.7	0.1	2.0	0.7	-0.5	0.4
Medication: Omeprazole	0.8	0.9	2.4	-0.2	-1.3	-1.6	-0.4	-0.6	1.3	-0.0
Medication: Seretide 50 evohaler	1.0	1.1	5.6	-0.4	-2.4	-0.9	-0.4	-0.5	0.6	-0.7
Mean time to correctly identify matches	0.1	0.2	0.9	0.5	-0.3	-0.3	-0.3	-0.5	0.9	0.4
Heart disease (mother)	0.6	0.7	2.7	-0.2	-0.1	0.5	1.6	0.6	1.1	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	3.0	-0.4	0.3	0.3	1.7	0.1	0.0	-0.5
Whole body fat mass	1.3	5.6	9.8	0.1	-2.3	-3.0	-2.4	-3.1	2.5	1.8
Leg fat mass (right)	1.3	5.0	8.4	0.1	-1.8	-2.9	-2.8	-2.8	2.6	1.1
Arm predicted mass (right)	0.2	0.9	2.1	-1.0	0.4	-1.5	-0.9	-0.4	1.3	-0.8
Pulse rate, automated reading	1.5	4.7	9.6	-1.4	1.0	-2.4	-2.3	-3.1	0.2	3.0
Alcohol intake frequency.	0.3	0.7	3.0	-1.0	-0.2	-0.7	-0.6	-0.0	-1.7	0.2
Comparative height size at age 10	0.3	1.7	3.9	-1.6	0.5	0.2	2.0	1.6	-1.6	-0.4
Number of full sisters	0.8	1.0	1.6	-1.3	0.3	-0.7	-0.9	-1.3	-1.2	1.0
Suffer from ‘nerves’	0.5	0.8	2.9	0.5	-0.6	0.5	-0.2	-0.4	-1.7	1.3
Overall health rating	0.3	0.6	2.3	-1.5	-0.2	-0.8	-0.9	-0.3	-0.7	-0.1
Chest pain or discomfort	0.2	0.2	0.9	-0.6	-0.5	-0.2	0.0	0.1	-0.9	-0.2
Had major operations	2.6	3.1	8.2	0.7	-1.7	-2.2	-0.4	-2.1	2.9	1.0
Age at last live birth	0.7	1.0	3.2	1.0	1.2	-0.2	-0.1	-1.0	-0.3	1.8
Family relationship satisfaction	0.3	0.4	1.1	0.6	-1.0	0.2	-0.6	0.3	-0.9	-0.5
Leg pain on walking	0.8	1.0	3.0	-1.4	-0.2	-0.1	-0.9	-0.3	-1.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	5.1	2.2	0.3	0.8	0.1	0.5	2.2	-0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.3	-0.4	-0.9	0.1	-0.3	0.3	-1.5	-0.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	6.4	-0.5	-0.1	-2.5	-1.3	-0.3	0.5	0.1
Medication: Aspirin	0.9	1.2	5.0	-0.7	-0.3	-0.1	-0.6	-1.5	-0.7	2.2
Supplements: Vitamin C	0.4	0.5	2.3	0.4	-0.1	0.8	0.4	-0.4	1.5	0.5
Knee pain experienced in last month	0.6	1.0	3.0	0.4	1.0	0.5	-0.3	1.1	-1.7	-1.1
Hypertension (Self-reported)	1.7	4.7	17.4	-1.2	-2.4	-4.2	-1.4	-1.9	-0.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	6.5	2.6	-1.6	1.0	0.9	0.1	0.3	0.8
Illnesses of father: Heart disease	1.2	1.7	2.3	-1.0	1.4	1.4	0.8	1.5	-1.3	-1.4
Illnesses of siblings: Diabetes	0.7	0.9	4.4	-2.1	0.2	-0.6	-0.4	-0.1	-0.6	0.8
Smoking status: Previous	1.0	1.5	4.7	1.0	-2.2	-1.4	-0.8	-1.1	1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	0.2	-1.1	-1.0	-0.8	-0.6	-0.1	0.6
Whole body fat-free mass	0.1	0.6	2.8	-0.8	0.5	-0.6	0.0	-0.1	1.7	-0.7
Leg fat-free mass (right)	0.1	0.8	4.2	-0.2	0.7	-0.0	0.4	-0.7	2.0	0.1
Arm fat percentage (left)	1.9	7.7	15.7	0.6	-2.7	-2.6	-2.4	-4.0	3.1	2.9
Average weekly red wine intake	0.4	0.6	1.8	0.5	-1.1	-0.8	0.2	-0.4	1.3	0.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.0	-0.1	-1.6	-0.7	0.2	-0.5	2.0	0.8
Mood swings	0.5	0.8	1.8	-0.9	0.3	0.9	0.0	0.8	-1.4	-1.2
Loneliness, isolation	0.5	0.7	2.0	0.1	-1.4	0.7	-0.8	-0.8	-1.0	0.5
Long-standing illness, disability or infirmity	1.2	1.8	3.6	-1.6	-1.9	-1.4	-1.0	-1.5	0.3	1.2
Ever had bowel cancer screening	0.9	1.0	2.1	-0.6	-0.1	-1.4	-0.6	-1.4	-0.8	1.3
Diabetes diagnosed by doctor	0.5	0.8	2.7	-1.1	-0.1	-0.4	-0.2	-1.0	-0.6	1.6
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	4.5	-1.6	-1.4	-1.9	-0.9	-1.3	-2.1	1.5
Friendships satisfaction	0.3	0.4	1.0	-0.1	0.3	1.0	1.0	0.7	-0.5	-0.2
Qualifications: nursing, teaching	1.0	1.5	2.9	-0.6	-1.3	-0.7	-1.7	-1.3	-1.0	1.5
Commuting to job workplace: Walk	0.7	0.7	1.6	-0.4	0.6	0.8	0.7	-1.2	0.4	1.2
Eye problems/disorders: Cataract	1.0	1.2	4.0	0.1	-1.0	-2.0	-1.3	-0.9	-0.8	0.5
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.7	1.2	-1.9	-1.5	-2.2	-2.6	0.1	2.1
Medication for cholesterol	0.6	0.9	2.3	1.2	0.8	1.5	0.3	0.6	-0.1	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	6.2	0.1	-2.5	-2.3	-1.9	-1.7	1.3	1.0
Back pain experienced in last month	0.7	1.1	2.6	0.2	-1.1	-1.1	-1.6	-0.9	1.2	0.1
Mineral and other dietary supplements	1.6	2.1	7.7	2.8	-1.9	0.2	-1.5	-1.0	0.2	0.1
Breast cancer (self-reported)	0.8	0.9	2.5	0.4	-1.6	-1.0	-0.1	-0.9	-0.2	1.4
Asthma (self-reported)	0.4	0.9	3.2	-1.8	0.2	0.3	0.5	0.1	-1.5	0.6
Osteoporosis (self-reported)	0.1	0.2	0.4	0.3	-0.3	0.5	0.5	0.7	-0.0	0.0
Osteoarthritis (self-reported)	0.6	0.8	3.3	0.8	0.0	-0.2	-1.8	-0.5	-1.2	-0.5
Medication: Aspirin	0.7	0.9	3.3	-0.9	0.1	-0.1	-0.4	-1.1	-0.9	1.8
Medication: Gliclazide	0.3	0.3	1.0	0.1	-0.4	-0.4	0.6	-0.7	-0.4	1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.7	-1.4	0.1	0.9	1.2	0.8	1.7	-0.3
Smoking status: Current	0.6	0.9	2.1	-0.1	1.3	1.4	0.9	0.9	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.9	0.1	2.2	1.3	1.3	0.2	-0.3	0.1
Whole body water mass	0.1	0.6	2.6	-0.8	0.5	-0.6	0.1	-0.2	1.6	-0.6
Leg predicted mass (right)	0.1	0.8	4.2	-0.2	0.6	-0.1	0.4	-0.8	2.1	0.2
Arm fat mass (left)	1.2	4.8	8.6	0.2	-2.1	-2.5	-2.2	-2.9	2.8	1.6
Number of self-reported non-cancer illnesses	1.9	3.4	5.7	-1.5	-2.4	-2.4	-0.7	-1.9	-0.7	2.3
Average weekly champagne plus white wine intake	0.5	0.7	2.1	1.1	-1.0	-0.3	0.0	-0.2	-1.5	0.3
Miserableness	0.3	0.5	1.0	-1.0	-0.8	-0.5	-0.6	-0.5	-1.0	0.3
Guilty feelings	0.3	0.5	2.4	-0.3	-0.3	1.5	0.9	0.2	0.0	0.4
Wears glasses or contact lenses	0.9	1.1	4.0	-0.4	-1.4	-2.0	-0.1	-1.0	-0.5	-0.2
Ever taken oral contraceptive pill	2.8	3.2	7.2	2.7	-2.0	-2.0	-1.6	-1.9	0.6	0.6
Hearing aid user	0.8	0.9	2.0	-1.4	-0.7	-1.3	-1.0	-0.7	-0.3	-0.3
Mother’s age at death	0.5	0.6	2.9	0.6	-0.1	-0.2	-0.3	-0.7	1.7	0.3
Financial situation satisfaction	0.7	0.9	3.0	-1.7	0.7	0.6	0.4	0.1	1.1	0.9
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.9	-0.4	-0.9	0.3	-0.6	-0.5	0.1	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.6	0.0	-0.1	0.2	0.3	0.4	-0.1
Eye problems/disorders: Glaucoma	0.7	0.9	3.5	-1.3	-0.3	-0.1	-0.6	-0.2	-1.9	0.5
Medication: Blood pressure	0.5	0.9	2.7	-1.3	-0.1	-1.6	-0.3	0.4	-1.4	0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	-0.5	-0.6	-0.8	-1.0	-0.0	-1.0	-0.9
Supplements: Fish oil (including cod liver oil)	1.3	1.7	5.0	-1.7	2.2	-0.1	1.4	1.3	-0.8	-0.5
High cholesterol (Self-reported)	1.0	1.8	5.7	-0.3	-1.0	-1.2	-0.9	-1.9	0.2	2.4
Medication: Bendroflumethiazide	1.1	1.7	9.4	-0.2	0.7	0.0	1.1	0.7	-3.1	-0.2
Medication: Paracetamol	0.1	0.2	0.4	0.5	0.4	-0.4	-0.3	-0.6	0.6	0.1
Medication: Lisinopril	1.0	1.3	4.3	0.1	-1.0	-2.1	-0.6	-1.0	-1.0	1.1
Medication: Atorvastatin	1.1	1.4	3.9	0.4	-0.6	-1.2	-0.8	-1.1	2.0	1.4
Illnesses of father: High blood pressure	0.9	1.1	5.4	-1.2	-0.1	-0.3	0.9	0.4	-2.3	-0.2
Alcohol drinker status: Never	1.3	1.6	5.6	-1.6	0.4	-1.3	-0.2	-1.1	0.1	2.4
Ever smoked	0.7	1.2	2.8	1.7	-1.4	-0.9	-0.4	-0.8	1.4	-0.3
Basal metabolic rate	0.1	0.7	3.5	-0.5	0.1	-0.8	-0.3	-0.6	1.9	-0.3
Leg fat percentage (left)	1.8	6.5	12.5	0.2	-2.5	-3.5	-3.4	-3.3	1.7	1.3
Arm fat-free mass (left)	0.2	0.8	1.6	-1.0	0.4	-1.1	-0.7	-0.0	1.1	-1.3
Number of operations (self-reported)	0.6	0.9	1.9	-0.5	0.0	-0.8	0.7	-1.4	1.1	1.3
Average weekly beer plus cider intake	1.0	1.4	3.1	0.0	1.5	1.2	1.1	-0.0	1.8	1.2
Irritability	0.3	0.4	1.2	-0.2	0.5	-0.9	-0.0	0.3	-1.1	-0.8
Risk taking	0.3	0.5	1.2	-0.7	-1.0	-0.3	-0.4	0.3	1.1	-0.4
Ever had prostate specific antigen (PSA) test	2.2	2.6	8.7	0.1	0.4	-0.4	-0.5	1.8	-2.9	-2.3
Fractured/broken bones in last 5 years	0.8	1.0	5.0	0.2	-0.5	-0.8	-2.2	-0.9	-0.6	0.0
Age started oral contraceptive pill	0.4	0.5	1.3	-0.5	1.1	0.4	0.2	1.1	0.3	-0.9
Diastolic blood pressure, automated reading	0.4	1.4	4.6	-0.1	-0.6	-2.1	-1.2	-1.5	0.9	0.5
Ever depressed for a whole week	0.4	0.4	1.7	-0.3	-0.8	-0.3	-1.3	0.4	-0.1	-0.6
Unable to work because of sickness or disability	1.1	1.5	4.4	-1.5	0.6	2.1	1.2	1.2	0.6	0.1
Commuting to job workplace: Cycle	0.7	0.9	2.8	-1.3	1.7	0.6	1.1	0.4	0.3	0.2
Myopia	0.3	0.5	1.0	0.2	1.0	0.3	0.9	0.8	0.6	-0.8
Vascular/heart problems diagnosed by doctor	1.7	4.6	15.5	1.5	2.8	3.9	1.2	1.7	0.2	-1.4
Cholesterol lowering medication	0.3	0.5	1.0	-0.5	-0.9	-1.0	-0.3	-0.3	0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.7	-0.2	-1.5	-1.1	0.3	-0.6	1.9	0.3
Pain experienced in last month	1.0	1.7	3.1	-1.0	1.3	0.9	1.5	1.7	1.0	-1.4
Supplements: Calcium	0.3	0.3	0.9	-0.4	0.5	0.4	0.9	0.6	0.6	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.3	-0.3	0.2	-0.5	-1.1	-0.2	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.9	-1.2	-1.4	-0.9	-1.1	-0.3	-1.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	-1.4	1.1	0.6	0.8	0.7	-0.6	0.3
Heart disease (siblings)	1.5	1.9	4.7	-0.5	-2.1	-2.2	-1.3	-1.2	0.2	0.2
Alcohol drinker status: Previous	1.4	1.5	4.4	-0.1	0.5	1.7	2.1	1.1	-1.5	0.1
Pack years of smoking	0.6	0.9	3.3	-0.3	0.9	0.6	1.0	-0.6	0.5	1.8
Impedance of whole body	0.5	2.5	7.1	1.0	-2.7	-0.3	-0.5	-0.9	-1.6	2.4
Leg fat mass (left)	1.2	4.8	8.4	0.0	-1.7	-2.9	-2.7	-2.9	2.4	1.1
Arm predicted mass (left)	0.2	0.8	1.8	-1.1	0.2	-1.1	-0.5	0.0	1.2	-1.3