Hub : Genes

ITGA6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2290 0.0430 8.4e-11 0.065 0.110 0.129 0.127 0.136 2.5e-08 2.5e-13 2.0e-15 3.1e-15 3.2e-16
2 GTEx Adipose Subcutaneous 0.1990 0.0630 1.6e-03 0.023 NA 0.007 NA 0.026 5.1e-03 NA 8.7e-02 NA 3.2e-03
3 GTEx Artery Aorta 0.1750 0.0600 3.4e-03 0.047 NA 0.069 NA 0.047 1.3e-03 NA 1.2e-04 NA 1.4e-03
4 ROSMAP Brain Pre-frontal Cortex 0.1120 0.0351 1.6e-04 0.007 0.038 0.040 0.039 0.025 3.6e-02 1.1e-05 6.2e-06 7.2e-06 3.4e-04
5 YFS Blood 0.0286 0.0123 1.4e-03 0.002 0.010 0.003 0.010 0.004 6.2e-02 1.6e-04 3.4e-02 2.8e-04 1.1e-02
6 TCGA Prostate Adenocarcinoma 0.0994 0.0428 3.9e-06 0.048 0.038 0.039 NA 0.027 8.5e-06 7.6e-05 5.8e-05 NA 7.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.0 1.5 2.0 1.2 1.2 1.2 1.4 1.0 1.4
Bipolar Disorder or Schizophrenia 0.4 1.0 2.2 1.5 1.2 -0.3 1.0 1.1 0.2
Depressed Affect (Nagel 2018) 0.6 1.2 3.2 -1.8 -0.4 1.8 0.4 0.6 0.4
Depression (Nagel 2018) 0.2 0.3 0.9 -0.6 0.4 -0.4 0.6 0.2 -1.0
Intelligence (Savage-Jansen 2018) 0.1 0.2 1.2 1.1 0.2 0.1 -0.2 0.0 -0.3
Neuroticism (Nagel 2018) 0.4 1.0 2.9 -1.6 -0.5 1.7 -0.4 0.3 -0.1
Schizophrenia (2018) 0.3 0.7 1.7 1.0 0.6 -1.3 0.1 0.5 -0.9
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 0.3 -0.4 0.5 -0.4 0.2 -0.9
Worry (Nagel 2018) 0.2 0.4 0.9 -0.9 -0.9 0.8 -0.2 0.1 -0.3
Alzheimer’s Disease (in mother) 0.7 0.8 2.7 0.3 -1.6 -1.3 0.1 -0.6 0.3
Alzheimer’s Disease (in father) 0.6 0.7 1.9 -1.1 -1.4 -0.4 -0.5 0.4 -0.6
Alzheimer’s Disease (including proxy) 0.9 1.3 4.2 -0.8 -2.1 -1.4 -0.5 -0.4 -0.8
Crohns Disease (2017) 0.8 1.8 5.6 0.1 1.4 1.5 0.6 2.4 0.7
Irritable Bowel Disease (IBD) 0.2 0.4 1.4 -0.3 0.9 0.4 0.1 1.2 0.4
Ulcerative Colitis (UC) 0.1 0.2 0.5 -0.5 0.4 -0.7 -0.6 0.0 -0.3
Major Depression (MDD) 1.4 1.7 5.5 0.6 1.3 2.3 0.9 0.0 1.3
Reaction Time 0.5 0.9 3.4 -0.1 0.1 -1.0 0.7 0.8 -1.9
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.5 -0.4 -0.2 -0.0 -1.2 -0.7 -0.3
Breast Cancer 1.3 3.0 8.6 1.8 2.2 1.0 0.1 -0.9 -2.9
Ovarian Cancer 0.7 1.0 2.5 0.3 1.3 1.3 -0.1 -0.1 -1.6
Prostate Cancer 8.0 11.3 57.6 1.9 0.6 -0.0 2.5 0.1 7.6
Age at First Birth 1.0 1.5 2.0 -1.3 -1.4 -1.3 -1.3 -0.9 -1.0
Bipolar Disorder (2011) 0.7 0.7 1.4 1.2 1.2 1.1 0.1 0.5 -0.2
Body Mass Index (BMI) (2010) 0.7 0.9 5.3 0.1 -0.4 2.3 0.2 0.2 0.4
Coronary Artery Disease (CAD) 0.4 0.5 2.3 -0.2 -0.3 0.1 -1.5 0.3 -0.7
Crohns Disease (2012) 1.2 1.9 4.9 -0.3 1.2 2.2 0.4 2.2 -0.2
Mean Putamen Volume 1.1 1.3 4.5 0.5 0.1 0.2 0.5 -2.1 -1.6
Fasting Glucose 1.8 2.2 6.4 -1.3 0.5 2.5 0.7 1.6 1.3
HbA1C 1.1 1.3 3.4 -1.2 -1.2 -0.2 -0.7 1.9 -0.9
HDL Cholesterol 0.5 0.8 1.9 -0.6 -1.4 -1.3 -0.3 -0.8 0.2
LDL Cholesterol 0.2 0.4 1.1 0.1 1.0 0.7 -0.1 -0.7 -0.2
Lupus 0.2 0.3 1.2 -1.1 0.3 0.3 0.3 -0.5 0.4
Neuroticism (2016) 0.3 0.5 1.0 -0.5 0.4 1.0 0.9 0.2 0.7
Primary Biliary Cirrhosis 1.1 1.6 3.9 -0.0 2.0 1.7 1.1 1.3 -0.5
Rheumatoid Arthritis 0.9 1.2 3.0 1.3 0.5 1.4 0.1 -1.7 -0.7
Schizophrenia (2014) 0.4 0.8 1.7 1.3 1.1 -0.4 0.4 1.1 -0.6
Triglycerides 0.5 0.9 2.8 1.0 1.7 0.7 0.2 1.0 -0.3
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.5 -0.1 -0.4 0.5 0.7 0.6 -0.6
Ulcerative Colitis 0.3 0.4 1.1 0.6 1.1 -0.5 0.5 -0.5 -0.3
Blood Eosinophil Count 0.5 4.2 7.0 -1.5 -2.5 -0.5 -2.0 2.3 -2.6
Blood Platelet Count 1.5 17.7 33.5 3.0 3.6 3.3 5.8 5.6 3.0
Blood Red Count 0.1 1.0 1.9 0.4 0.9 1.4 1.2 1.0 1.0
Blood White Count 0.1 0.8 2.7 -0.7 -0.9 -0.3 0.5 1.6 -0.7
Heel T-Score 0.0 0.4 1.0 0.1 -0.2 0.0 -1.0 -0.6 -1.0
BMI 0.1 0.7 2.1 0.4 0.0 1.3 1.5 0.5 0.1
Height 0.0 0.6 2.8 0.8 -0.0 1.7 0.3 0.2 -0.2
Waist Hip Ratio (WHR) 0.8 3.4 7.8 2.8 2.1 1.2 2.4 1.0 -0.4
Systolic Blood Pressure 0.5 2.5 4.5 -1.7 -1.9 -2.1 -1.9 0.4 -0.3
Smoking Status 0.2 0.5 1.4 -0.4 0.6 1.2 0.5 0.4 0.9
Allergy or Eczema 0.8 2.1 4.3 1.7 0.6 -2.1 0.5 -2.0 1.0
Cardiovascular Disease 0.7 2.3 7.4 -1.0 -1.2 -1.7 -0.5 0.8 -2.7
Hypothyroidism (self reported) 0.1 0.2 0.8 0.5 -0.9 -0.6 0.2 0.0 -0.2
Respiratory disease 0.5 1.0 3.8 0.4 0.7 -0.3 0.2 1.3 -1.9
Type 2 Diabetes (T2D) (2018) 1.1 2.0 8.2 0.0 -1.8 -0.4 0.3 -0.7 -2.9
Lung FEV1/FVC ratio 0.3 1.6 4.6 0.6 0.9 1.0 -0.3 2.1 1.7
Lung FVC 0.1 0.4 0.8 -0.2 0.6 0.7 -0.9 -0.7 -0.5
Neuroticism 0.4 1.1 3.6 -0.7 0.2 1.9 1.1 0.4 0.8
Chronotype (morning person) 0.4 1.0 4.0 -0.6 -2.0 -0.6 -0.5 1.0 -0.1
Hair Pigment 0.1 3.8 9.6 -2.6 -3.1 -0.1 -2.1 1.4 -0.2
Tanning 0.1 0.8 3.6 -0.6 -0.4 1.9 0.5 -0.0 0.8
Hand grip strength (left) 0.1 0.3 0.8 0.2 -0.1 0.8 0.1 0.6 -0.9
Number of treatments/medications taken 0.4 0.8 3.0 0.1 -1.7 -0.2 -0.4 1.0 -0.8
Average weekly spirits intake 0.3 0.3 1.4 -0.2 0.4 1.2 0.2 0.4 0.4
Sensitivity / hurt feelings 0.7 1.2 3.3 -1.8 -0.2 1.4 -0.5 -0.2 -1.2
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.9 -0.3 0.3 0.4 0.5 -1.0 -0.1
Hearing difficulty/problems: Yes 0.8 1.2 4.7 0.3 -0.3 -1.0 -1.0 0.4 -2.2
Relative age of first facial hair 0.6 1.2 2.2 1.2 1.5 0.8 1.4 0.4 -1.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.0 1.3 -0.2 0.2 0.1 0.2 -1.4
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.5 -0.2 -0.1 0.2 0.7 -0.6 -0.4
Ever had hysterectomy (womb removed) 2.0 2.2 6.9 -0.8 -1.4 -2.6 -1.0 -0.7 -1.5
Systolic blood pressure, automated reading 1.2 3.4 11.1 -3.3 -1.2 -1.3 -2.2 0.8 1.0
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.8 -0.5 -1.1 -0.4 -1.5 -0.3 -2.0
Angina 0.5 0.7 2.1 -0.2 -1.4 0.3 -0.2 0.3 -1.3
Medication for hormone replacement therapy 2.3 2.6 11.4 -0.2 1.0 1.6 -0.9 0.0 -3.4
Vitamin and mineral supplements 0.8 1.1 2.8 1.2 0.9 -0.8 1.7 0.5 -0.6
Supplements: Zinc 0.3 0.3 0.7 -0.4 -0.7 -0.4 -0.8 -0.6 -0.4
Medication: Co-codamol 0.3 0.3 1.3 0.6 1.1 0.3 0.5 -0.1 0.3
Medication: Metformin 0.7 1.0 1.7 1.3 -0.6 -0.5 1.1 -1.0 -1.1
Diabetes (father) 0.4 0.5 1.3 0.1 -1.0 0.2 0.7 1.2 0.7
Diabetes (mother) 0.4 0.5 1.9 -0.6 -0.2 0.3 0.1 -0.9 1.4
Severe depression (siblings) 0.8 0.9 1.9 -0.8 -0.7 -0.2 -1.1 -0.9 -1.4
Pack years adult smoking proportion 1.6 2.4 8.8 -1.9 0.2 3.0 1.0 -0.3 1.0
Impedance of leg (right) 0.1 0.5 1.8 0.3 -0.3 -1.3 0.5 -0.8 0.3
Leg fat-free mass (left) 0.2 1.0 1.7 -1.0 -0.7 1.3 -0.5 1.2 -1.1
Trunk fat percentage 0.1 0.5 1.7 -0.2 -0.9 0.3 0.3 1.3 0.6
Hand grip strength (right) 0.4 1.0 2.0 0.4 1.0 1.2 0.4 1.0 -1.4
Townsend deprivation index at recruitment 2.0 2.8 8.6 1.8 1.4 2.9 1.4 0.4 0.9
Current tobacco smoking 0.8 1.2 2.8 -1.1 0.9 1.7 0.1 1.2 1.2
Average weekly fortified wine intake 1.8 2.1 7.5 0.7 2.1 0.1 0.4 0.0 2.7
Maternal smoking around birth 0.8 1.2 3.3 -0.7 1.8 1.0 0.6 0.6 1.2
Fed-up feelings 0.6 1.2 3.2 -1.8 0.0 1.6 0.3 1.0 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 0.2 0.7 -0.0 1.0 -0.7 0.6
Relative age voice broke 0.5 0.7 1.6 -0.2 -0.9 -0.7 -1.3 0.0 -1.1
Taking other prescription medications 0.2 0.3 0.9 -0.3 -1.0 -0.0 -0.1 0.7 -0.7
Age when periods started (menarche) 0.5 1.3 4.4 2.1 1.4 -0.4 1.1 0.3 0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 -0.8 -0.9 0.7 -0.4 0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.9 -0.7 -0.8 0.7 -0.6 -1.0 -0.2
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.6 0.9 0.5 1.3 0.6 -1.1 1.2
Qualifications: CSEs or equivalent 0.8 1.1 2.1 -1.4 -1.4 1.4 -0.6 -0.4 0.1
Serious illness, injury or assault to yourself 0.2 0.3 1.0 0.1 0.7 0.1 1.0 -0.3 0.5
High blood pressure 0.8 2.1 5.4 -2.3 -2.1 -0.6 -1.0 0.7 -1.1
Hayfever, allergic rhinitis or eczema 0.8 1.7 4.2 1.6 0.7 -1.5 0.5 -2.0 0.2
Multivitamins +/- minerals 1.0 1.2 2.6 -1.6 -0.1 0.7 -1.3 -1.0 1.3
Stomach or abdominal pain in last month 0.2 0.2 0.8 0.1 0.1 0.2 0.9 -0.1 -0.5
Supplements: Glucosamine 0.8 1.0 3.1 0.4 0.0 -0.9 0.6 -1.3 1.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.0 1.0 0.2 -0.5 0.2 0.6 -0.2
Medication: Atenolol 1.0 1.3 4.7 -0.7 -2.2 -0.6 -0.6 -1.0 0.9
Medication: Levothyroxine sodium 0.9 1.5 2.8 -1.5 -1.5 -1.3 -1.7 -0.1 -0.2
Sitting height 0.1 0.6 1.6 -0.6 0.2 1.3 -0.0 0.5 -1.0
Chronic bronchitis/emphysema (father) 2.7 3.2 5.7 0.4 2.1 2.4 1.7 -2.3 0.7
High blood pressure (mother) 0.8 1.1 2.7 1.1 -1.2 -1.6 -0.1 -1.1 0.1
Body mass index (BMI) 0.1 0.5 1.3 -0.9 -0.4 1.1 0.5 0.8 0.3
Impedance of leg (left) 0.2 1.0 2.3 1.0 -0.1 -0.9 0.9 -1.5 1.0
Leg predicted mass (left) 0.2 1.0 1.7 -1.0 -0.7 1.3 -0.4 1.1 -1.1
Trunk fat mass 0.1 0.5 1.3 -0.5 -0.8 0.8 0.4 1.2 0.2
Waist circumference 0.1 0.4 1.0 -0.2 0.1 0.7 1.0 0.7 0.2
Number of incorrect matches in round 0.6 0.9 1.9 1.1 1.4 -0.5 0.9 -0.8 -0.8
Past tobacco smoking 0.8 1.5 2.8 -0.9 -1.4 -1.4 -1.7 0.3 -1.1
Alcohol usually taken with meals 1.1 1.8 5.3 0.5 -0.8 -2.3 -0.9 -1.9 0.5
Nervous feelings 0.1 0.3 0.6 0.6 0.2 -0.5 0.5 -0.8 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.4 0.4 -0.5 0.1 0.1 -0.5 0.6
Hearing difficulty/problems with background noise 0.6 0.9 3.6 -0.2 -0.7 -1.9 -0.9 -0.4 -0.6
Hair/balding pattern: Pattern 2 1.7 2.1 8.9 -0.1 0.7 0.2 0.8 3.0 1.7
Had menopause 0.4 0.5 1.7 -0.1 -0.3 -1.0 0.4 -0.1 1.3
Had other major operations 0.3 0.4 1.1 -0.0 -1.0 -0.3 -1.0 -0.5 -0.0
Forced vital capacity (FVC) 0.0 0.1 0.4 -0.0 -0.1 0.5 0.3 -0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.0 -0.9 -0.9 1.4 -0.9 -0.4 0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.2 -0.3 -1.1 -0.2 -1.5 0.6 -1.0
Qualifications: None of the above 0.3 0.6 1.4 -0.8 0.6 1.2 0.0 0.7 -0.9
Financial difficulties in last 2 years 1.3 1.7 4.0 -0.1 0.7 1.8 0.6 -1.6 2.0
Mouth/teeth dental problems 0.7 1.0 3.3 0.9 0.3 -1.3 0.4 -0.2 -1.8
Heart attack 0.6 0.8 2.5 0.6 0.2 1.3 0.2 0.5 -1.6
Allergy 0.8 1.8 4.0 -2.0 -1.8 1.1 -1.3 0.8 0.1
Pain all over the body in last month 0.3 0.3 0.8 -0.8 -0.9 0.1 -0.3 0.2 -0.2
Diabetes (self-reported) 2.2 3.4 15.5 -0.9 -1.8 -0.6 -0.4 -0.2 -3.9
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 3.8 1.1 0.7 -1.5 -0.3 -1.9 0.7
Medication: Ramipril 2.0 2.5 12.0 0.3 -0.6 -1.5 -0.7 0.3 -3.5
Medication: Simvastatin 0.6 0.8 1.6 1.1 0.8 -0.6 1.0 -0.1 -1.3
Fluid intelligence score 0.4 0.9 4.1 0.9 0.4 -0.6 0.0 -2.0 0.3
Illnesses of siblings 0.5 0.6 1.6 1.2 -0.8 0.2 1.0 -0.1 -0.7
Neuroticism score 0.6 1.2 4.6 -1.1 -0.1 2.1 0.5 0.6 1.1
Weight 0.1 0.6 1.6 -1.0 -0.6 1.2 0.3 0.7 -0.3
Impedance of arm (right) 0.1 0.4 1.4 1.2 -0.3 -1.0 -0.2 0.2 0.2
Arm fat percentage (right) 0.1 0.5 2.1 -0.7 -0.7 0.3 0.1 1.4 0.2
Trunk fat-free mass 0.1 0.6 1.8 -1.3 0.0 1.3 -0.2 0.2 -0.5
Hip circumference 0.1 0.5 1.9 -1.4 -0.8 0.3 -0.5 0.3 -0.1
Time employed in main current job 0.1 0.1 0.3 0.1 -0.3 -0.0 0.2 0.4 -0.5
Alcohol intake versus 10 years previously 0.3 0.4 1.1 0.2 0.3 1.0 1.0 -0.5 -0.4
Father’s age at death 0.5 0.7 2.5 -0.1 -0.4 -0.0 0.1 -1.6 -1.3
Worrier / anxious feelings 0.4 0.8 1.8 -1.0 -0.9 1.3 1.0 0.1 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.9 -0.3 -0.6 1.0 0.3 0.4 0.5
Falls in the last year 0.1 0.1 0.2 -0.3 0.5 0.0 0.2 -0.4 0.4
Hair/balding pattern: Pattern 3 0.9 1.3 3.3 0.3 -0.1 0.6 -0.9 -1.8 -1.8
Number of live births 0.2 0.2 0.9 -0.9 0.1 -0.1 -0.6 0.3 -0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.8 0.4 -0.2 0.8 0.0 0.9 -0.6
Pulse rate 0.9 1.5 3.6 -1.4 -1.5 -1.9 -0.8 0.6 0.4
Happiness 0.7 0.8 1.4 -0.3 1.2 0.8 1.0 -0.7 1.1
Noisy workplace 1.2 1.5 2.9 0.9 1.4 1.7 1.5 1.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.8 0.6 -0.8 -1.3 -0.5 -1.1 -1.1
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 5.2 0.6 -1.3 -2.3 -1.0 -1.7 0.8
Mouth/teeth dental problems: Dentures 1.4 2.3 8.3 -2.9 0.1 1.3 -1.1 0.3 1.6
Asthma 0.9 1.8 3.6 1.9 1.7 -0.0 1.5 0.8 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 2.2 -1.1 -1.5 -0.3 -0.6 0.7 1.4
Medication: Cholesterol lowering 0.7 1.0 3.2 0.4 0.9 -0.1 1.8 1.1 -1.0
Depression (self-reported) 0.6 0.7 3.1 -0.0 0.7 -0.3 -0.1 0.8 -1.8
Medication: Lansoprazole 0.5 0.6 1.1 1.0 -0.8 -0.5 0.8 -0.2 0.9
Prospective memory result 0.4 0.5 2.1 -0.2 -0.4 -0.2 -0.4 0.9 1.4
Lung cancer (father) 0.6 0.7 2.0 -1.0 0.5 0.3 -0.2 -0.8 -1.4
Illnesses of mother 0.8 1.0 2.2 0.1 1.2 1.5 0.4 1.1 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.0 0.6 0.3 1.0 0.2 0.0 -0.7
Pulse wave Arterial Stiffness index 1.1 1.2 3.7 0.7 -0.7 -1.2 1.0 -1.9 0.5
Impedance of arm (left) 0.2 0.8 2.4 1.4 -0.1 -1.6 -0.5 0.5 -0.1
Arm fat mass (right) 0.2 0.9 2.7 -1.0 -0.8 0.9 -0.0 1.6 -0.1
Trunk predicted mass 0.1 0.6 1.8 -1.4 -0.0 1.3 -0.2 0.1 -0.5
Standing height 0.0 0.3 1.2 -0.2 -0.2 0.4 -0.3 -0.2 -1.1
Length of working week for main job 1.0 1.1 2.2 -0.9 -1.2 0.7 -1.1 -1.5 0.0
Exposure to tobacco smoke at home 0.9 1.0 2.7 -0.5 1.5 0.5 -0.6 0.2 1.6
Breastfed as a baby 2.5 3.1 8.8 -0.1 0.2 -1.8 -3.0 -2.0 -1.5
Tense / ‘highly strung’ 0.7 1.1 3.8 0.8 0.1 1.9 1.3 0.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.0 -0.7 -0.1 0.4 -0.1 0.5
Hair/balding pattern: Pattern 4 0.6 1.4 4.7 1.0 -0.6 0.4 -0.7 -2.2 -1.4
Birth weight of first child 0.6 1.1 2.2 -0.9 -1.5 -1.3 -0.8 -0.2 -1.1
Peak expiratory flow (PEF) 0.6 1.3 2.9 1.3 0.6 1.4 0.9 1.7 -0.3
Pulse wave reflection index 1.1 1.4 4.0 1.2 0.3 -0.5 1.7 -2.0 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.3 -0.9 -1.1 1.0 -1.1 0.2 -0.6
Loud music exposure frequency 0.8 0.8 2.0 1.4 1.3 0.0 0.7 -0.2 -0.8
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 3.7 1.8 0.3 -0.0 1.9 -1.2 1.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.8 0.2 -0.3 1.4 -0.2 -0.4 0.9
Blood clot in the leg (DVT) 0.5 0.7 3.0 -0.7 0.6 -0.3 0.2 1.7 0.3
Medication: Paracetamol 1.2 2.0 4.4 1.8 0.6 2.1 1.7 -0.3 1.0
Headache pain in last month 0.5 0.8 4.6 -0.2 -0.0 0.1 0.4 0.2 -2.1
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.0 1.2 1.3 1.6 0.2 -1.7 1.4
Glaucoma (self-reported) 1.4 1.6 5.5 -0.1 -0.4 1.9 0.6 -0.2 2.3
Gout (self-reported) 1.6 2.2 5.7 -2.4 -1.5 -0.4 -1.6 0.2 -1.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.6 -0.7 -0.6 -0.5 -0.6 -0.2 -0.7
Medication: Amlodipine 0.1 0.2 0.5 0.0 -0.1 -0.6 -0.4 -0.1 0.7
Medication: Ventolin 100micrograms inhaler 1.5 1.9 4.1 1.6 1.8 1.3 2.0 -0.2 -0.2
Birth weight 0.6 1.4 7.4 -0.8 0.4 0.0 0.2 2.7 -0.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.7 -0.3 0.9 0.6 0.1 -0.1 0.0
High blood pressure (siblings) 0.9 1.4 3.8 -2.0 -0.1 -0.8 -1.7 -0.4 0.6
Forced vital capacity (FVC), Best measure 0.1 0.3 0.7 0.2 0.2 0.6 0.2 -0.7 -0.8
Body fat percentage 0.1 0.5 1.1 -0.7 -1.1 0.3 0.2 1.0 0.5
Leg fat percentage (right) 0.1 0.5 1.5 -1.2 -1.0 0.1 0.4 0.2 0.3
Arm fat-free mass (right) 0.1 0.7 1.9 -1.2 -0.7 1.4 -0.0 0.3 0.0
Exposure to tobacco smoke outside home 1.9 2.5 4.2 1.7 2.1 1.7 1.9 -1.0 0.8
Comparative body size at age 10 0.1 0.4 0.6 -0.8 -0.7 0.5 -0.5 0.3 -0.8
Number of full brothers 0.8 1.0 1.8 -0.6 1.1 1.1 -1.3 0.4 -1.1
Worry too long after embarrassment 0.3 0.6 2.2 -0.8 -0.2 -0.2 -1.5 0.2 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.5 0.9 0.4 0.2 0.8 -0.2 0.9 -1.0
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 0.5 -0.2 -1.0 0.7 0.6 0.6
Number of children fathered 1.5 1.6 3.1 -1.1 -1.0 -1.4 -1.4 1.8 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.6 -0.2 -1.6 -1.1 -0.8 0.1 0.6
Age at first live birth 0.5 0.8 2.0 -1.0 -1.4 -0.4 -0.7 0.5 -1.0
Pulse wave peak to peak time 1.2 1.4 4.0 -0.7 0.9 1.4 -0.9 2.0 -0.7
Health satisfaction 0.4 0.5 1.4 0.1 -0.0 0.7 1.2 0.8 0.8
Shortness of breath walking on level ground 0.3 0.3 1.9 0.2 -0.2 -0.2 0.1 -1.4 -0.1
Qualifications: College or University degree 0.6 1.9 7.2 0.8 -0.9 -2.7 -1.1 0.3 -1.3
Eye problems/disorders: None of the above 0.2 0.3 1.0 -1.0 -0.1 -0.4 0.3 0.4 -0.4
Mouth/teeth dental problems: Loose teeth 0.6 0.8 3.8 -0.2 -0.4 0.6 -0.4 0.3 1.9
Emphysema/chronic bronchitis 0.8 0.9 3.9 -0.5 -2.0 -0.4 -0.7 0.7 -0.4
Medication for pain relief, constipation, heartburn 0.9 1.5 3.9 -0.9 0.2 -1.1 -1.7 -0.5 -2.0
Neck or shoulder pain in last month 0.8 1.1 2.5 1.6 1.0 1.1 1.4 0.2 -0.3
Medication: Blood pressure 1.9 3.4 6.9 -2.1 -2.6 -1.6 -0.8 1.5 -1.8
Angina (self-reported) 0.4 0.6 1.8 -0.3 -1.4 0.2 -0.2 0.2 -1.1
Migraine (self-reported) 2.0 2.5 7.0 -1.3 -2.6 0.5 -1.0 0.1 -2.3
Medication: Ibuprofen 1.1 1.3 3.4 -1.5 -1.8 -0.4 -0.9 0.6 0.7
Medication: Allopurinol 0.9 1.2 2.9 -1.6 -0.9 -0.9 -1.7 0.3 -0.1
Medication: Omeprazole 2.3 2.8 4.6 1.7 2.1 1.9 2.1 -0.8 -0.6
Medication: Seretide 50 evohaler 1.4 1.6 5.0 1.0 -0.5 2.2 0.7 1.6 0.4
Mean time to correctly identify matches 0.4 0.7 2.1 -0.7 0.9 -0.5 0.3 1.5 -0.7
Heart disease (mother) 0.4 0.5 1.5 -0.5 0.5 0.8 -0.2 -1.2 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.3 0.5 -0.1 -1.2 0.3 -0.6 -1.0
Whole body fat mass 0.1 0.6 1.5 -0.8 -1.0 0.7 0.2 1.2 0.2
Leg fat mass (right) 0.2 0.7 2.0 -1.4 -1.1 0.5 0.1 0.8 -0.4
Arm predicted mass (right) 0.1 0.6 1.7 -1.1 -0.5 1.3 0.2 0.5 -0.2
Pulse rate, automated reading 0.7 2.2 4.2 -1.6 -1.7 -2.0 -1.2 0.6 1.2
Alcohol intake frequency. 0.3 0.6 1.4 -0.3 0.8 1.2 -0.1 0.5 -1.2
Comparative height size at age 10 0.2 0.9 4.7 -0.3 -0.1 0.2 -0.7 0.4 -2.2
Number of full sisters 0.3 0.4 1.2 -0.6 0.5 0.5 -0.3 0.5 -1.1
Suffer from ‘nerves’ 0.2 0.3 0.9 0.5 -0.6 -0.0 0.4 1.0 0.0
Overall health rating 0.4 0.9 2.7 -0.8 -0.2 1.2 1.7 0.2 0.4
Chest pain or discomfort 1.4 2.0 4.7 2.1 -0.4 -0.6 1.5 -2.2 0.4
Had major operations 0.1 0.1 0.4 0.0 0.3 -0.1 0.1 0.3 -0.7
Age at last live birth 0.4 0.5 1.4 -1.2 -1.1 0.1 -0.1 0.3 -0.6
Family relationship satisfaction 0.1 0.1 0.6 0.0 0.1 -0.2 -0.3 -0.2 0.8
Leg pain on walking 0.4 0.5 1.0 0.2 1.0 1.0 -0.0 0.5 1.0
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.8 4.6 2.1 0.9 1.6 1.9 0.8 2.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.5 -1.2 -0.4 0.8 -1.1 -1.1 0.2
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 4.7 0.1 -0.3 -0.5 -0.4 2.2 -1.2
Medication: Aspirin 0.8 1.1 1.9 -1.0 -1.3 -0.2 -0.3 1.4 -1.2
Supplements: Vitamin C 0.2 0.3 0.5 0.1 -0.6 0.5 -0.7 -0.0 0.6
Knee pain experienced in last month 0.3 0.4 1.1 0.6 -0.0 -0.8 0.2 0.6 -1.0
Hypertension (Self-reported) 0.5 1.5 3.6 -1.9 -1.7 -0.9 -0.6 0.4 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 3.8 1.9 1.4 -0.6 1.3 0.5 1.7
Illnesses of father: Heart disease 1.8 2.5 5.7 1.2 0.1 1.1 1.6 -2.4 2.0
Illnesses of siblings: Diabetes 0.8 1.0 2.7 -1.1 -0.4 -1.6 -0.9 1.0 -0.0
Smoking status: Previous 1.4 2.1 4.8 1.3 1.6 1.1 2.2 -0.9 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.5 0.4 0.4 1.4 1.6 -1.3 -0.1
Whole body fat-free mass 0.1 0.7 1.8 -1.3 -0.4 1.3 -0.4 0.4 -0.5
Leg fat-free mass (right) 0.1 0.8 2.2 -0.7 -0.7 1.5 -0.4 0.9 -0.8
Arm fat percentage (left) 0.1 0.5 2.6 -0.4 -0.6 0.1 0.1 1.6 0.3
Average weekly red wine intake 1.4 2.1 5.1 0.5 0.2 -2.3 0.3 -1.8 1.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.8 0.8 -0.2 -0.5 1.1 1.3 0.7
Mood swings 0.7 1.2 2.0 -1.4 -0.9 1.2 -0.1 1.3 1.1
Loneliness, isolation 1.4 1.9 7.0 -0.5 0.7 1.6 1.1 0.2 2.6
Long-standing illness, disability or infirmity 0.7 1.1 2.9 1.5 -1.0 -0.2 1.7 -0.4 0.0
Ever had bowel cancer screening 0.4 0.5 2.0 0.0 -0.1 -0.7 -0.1 0.6 1.4
Diabetes diagnosed by doctor 1.9 3.1 13.7 0.1 -1.9 -0.7 0.2 -0.9 -3.7
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 3.1 -0.1 -1.8 0.9 0.7 0.9 -0.6
Friendships satisfaction 0.4 0.5 2.1 -1.4 -0.1 -0.3 -1.0 0.0 0.0
Qualifications: nursing, teaching 1.7 2.6 5.2 -1.5 -2.0 -2.3 -1.4 -1.2 -0.8
Commuting to job workplace: Walk 2.9 3.1 5.6 1.6 1.8 0.6 2.4 1.8 2.0
Eye problems/disorders: Cataract 0.3 0.3 1.5 0.3 0.3 -0.2 0.3 -1.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.1 0.4 -0.9 0.4 0.5 0.5 1.0
Medication for cholesterol 0.5 0.8 2.0 -0.3 -0.1 -1.1 1.2 -0.0 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.4 1.1 0.8 -0.5 1.2 -0.5 0.5
Back pain experienced in last month 0.2 0.3 1.2 0.7 -0.3 1.1 0.1 -0.2 -0.5
Mineral and other dietary supplements 0.7 1.0 3.1 0.5 0.1 0.8 1.2 1.8 -0.7
Breast cancer (self-reported) 0.2 0.2 0.6 -0.2 -0.3 -0.6 -0.5 0.2 0.8
Asthma (self-reported) 1.0 2.1 4.6 2.1 1.7 -0.2 1.6 0.7 -1.3
Osteoporosis (self-reported) 0.4 0.4 1.1 -0.3 0.5 0.8 -1.0 -0.4 -0.7
Osteoarthritis (self-reported) 0.2 0.2 0.8 0.3 -0.3 0.1 0.2 -0.5 -0.9
Medication: Aspirin 1.0 1.3 2.2 -1.2 -1.5 -0.4 -0.5 1.5 -1.3
Medication: Gliclazide 1.3 1.4 5.7 0.1 -1.4 -2.4 -0.1 -0.9 -0.4
Illnesses of father: None of the above (group 1) 0.8 1.0 2.6 0.0 0.3 -0.9 -1.3 1.0 -1.6
Smoking status: Current 0.9 1.4 2.4 -1.2 1.0 1.6 0.0 1.5 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.4 -0.6 0.6 0.9 0.1 1.3 -1.6
Whole body water mass 0.1 0.7 1.9 -1.3 -0.4 1.4 -0.3 0.5 -0.5
Leg predicted mass (right) 0.1 0.7 2.1 -0.6 -0.7 1.5 -0.3 0.8 -0.8
Arm fat mass (left) 0.2 0.8 3.2 -0.7 -0.6 0.8 0.0 1.8 -0.2
Number of self-reported non-cancer illnesses 0.6 1.1 3.8 0.5 -0.8 -1.2 0.4 0.3 -1.9
Average weekly champagne plus white wine intake 1.0 1.3 4.3 -0.9 -2.1 -0.1 -0.9 1.3 -0.6
Miserableness 0.7 1.2 4.4 -1.0 -0.0 2.1 0.5 -0.2 1.1
Guilty feelings 0.9 1.3 2.2 -1.0 -0.8 0.7 -1.5 1.2 1.4
Wears glasses or contact lenses 1.1 1.3 3.5 -0.9 0.1 -1.1 -1.9 0.8 -1.3
Ever taken oral contraceptive pill 0.8 0.9 2.4 -0.8 -0.2 0.6 0.7 1.6 -1.2
Hearing aid user 0.7 0.8 3.1 0.7 1.8 0.3 0.7 0.1 -0.8
Mother’s age at death 0.5 0.7 1.6 -1.1 -0.9 -0.4 -1.3 -0.1 0.5
Financial situation satisfaction 1.2 1.5 2.4 0.5 1.5 1.2 1.6 -0.4 1.5
Tinnitus: Yes, now most or all of the time 2.6 3.1 10.6 -0.8 -1.3 -3.2 -1.7 -1.3 -0.9
Commuting to job workplace: Public transport 0.8 1.0 3.1 1.4 1.8 0.2 0.5 0.5 0.2
Eye problems/disorders: Glaucoma 1.7 2.0 5.5 0.6 -0.2 2.3 0.7 0.6 2.3
Medication: Blood pressure 0.2 0.3 0.9 0.4 -0.5 0.6 -0.9 0.2 -0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.7 -0.9 0.1 0.6 -0.3 0.1 0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.0 -0.5 0.1 0.1 -0.9 -1.0 -0.1
High cholesterol (Self-reported) 1.2 2.2 6.5 1.6 2.5 0.6 1.8 -0.3 -0.5
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.1 -0.6 0.1 -0.2 0.0 -0.3
Medication: Paracetamol 1.6 2.4 5.5 2.4 0.9 2.0 1.7 -0.4 1.0
Medication: Lisinopril 2.4 3.1 7.3 -0.3 -2.1 -2.7 -1.8 1.1 -1.6
Medication: Atorvastatin 0.5 0.6 1.7 0.2 1.1 0.9 0.2 1.3 0.0
Illnesses of father: High blood pressure 0.5 0.6 2.3 0.6 -1.5 0.2 0.6 0.7 0.3
Alcohol drinker status: Never 0.8 1.0 2.8 -0.7 -0.8 -1.7 -1.1 0.5 -0.6
Ever smoked 0.8 1.4 4.3 1.0 0.8 2.1 1.4 -0.5 0.6
Basal metabolic rate 0.1 0.7 1.9 -1.1 -0.5 1.4 -0.2 0.6 -0.6
Leg fat percentage (left) 0.1 0.4 0.6 -0.7 -0.7 0.5 0.8 -0.0 0.8
Arm fat-free mass (left) 0.1 0.7 2.1 -1.5 -0.7 1.3 0.1 0.1 -0.2
Number of operations (self-reported) 0.2 0.3 0.9 0.9 0.6 0.3 0.3 0.1 -0.6
Average weekly beer plus cider intake 0.5 0.7 2.0 -0.6 -0.2 1.3 1.4 0.1 0.1
Irritability 0.4 0.7 2.6 -0.7 0.3 0.6 -0.1 0.7 1.6
Risk taking 0.2 0.4 1.1 -0.4 -0.7 -1.0 -0.5 0.1 0.5
Ever had prostate specific antigen (PSA) test 1.2 1.3 5.6 1.2 2.4 0.0 0.6 -0.6 0.5
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.1 0.9 0.7 0.6 0.6 -0.4
Age started oral contraceptive pill 0.5 0.6 1.6 0.8 -1.0 -1.3 -0.8 -0.4 0.0
Diastolic blood pressure, automated reading 1.4 4.3 14.6 -3.8 -1.6 -0.9 -2.1 1.1 1.4
Ever depressed for a whole week 0.6 0.7 2.0 -0.6 -0.4 0.0 -1.1 -1.4 0.8
Unable to work because of sickness or disability 0.3 0.4 1.2 0.1 -0.4 0.4 1.0 -0.1 -1.1
Commuting to job workplace: Cycle 1.1 1.4 3.4 0.9 1.0 -1.6 0.3 0.6 -1.8
Myopia 0.2 0.3 1.2 0.1 -0.4 0.6 0.0 0.6 1.1
Vascular/heart problems diagnosed by doctor 1.2 3.2 6.7 2.6 2.4 1.1 1.6 -1.1 1.4
Cholesterol lowering medication 0.1 0.1 0.4 0.3 0.0 0.3 -0.7 -0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 4.5 1.6 2.0 1.1 2.1 -1.1 -0.3
Pain experienced in last month 0.4 0.7 2.7 -0.3 0.3 -1.0 -0.4 0.2 1.6
Supplements: Calcium 0.4 0.5 1.3 0.6 1.1 -0.0 -0.0 -1.0 0.3
Basal cell carcinoma (self-reported) 1.2 1.5 4.9 0.9 1.7 0.1 0.3 -2.2 0.0
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.9 0.4 0.0 1.1 -0.2 0.8 -2.0
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.5 -1.0 0.6 0.1 -0.0 1.9 0.4
Heart disease (siblings) 0.7 0.9 3.9 0.8 2.0 0.6 0.1 -0.3 0.3
Alcohol drinker status: Previous 0.8 0.9 2.9 0.6 1.7 0.9 0.7 0.7 -0.0
Pack years of smoking 1.8 2.6 9.2 -2.1 -0.1 3.0 0.9 0.0 1.2
Impedance of whole body 0.1 0.7 1.9 1.3 -0.3 -1.4 0.2 -0.5 0.3
Leg fat mass (left) 0.2 0.6 1.3 -1.1 -1.0 0.8 0.4 0.7 -0.1
Arm predicted mass (left) 0.2 0.8 2.5 -1.3 -0.6 1.6 0.2 0.2 -0.1