Hub : Genes

KIAA1328

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.09 0.029 8.2e-05 0.052 0.034 0.048 0.049 0.052 6.4e-07 4.4e-05 1.4e-06 1.2e-06 5.1e-07
2 YFS Blood 0.04 0.012 9.6e-13 0.023 0.048 0.040 0.048 0.046 2.9e-08 2.1e-15 5.8e-13 2.1e-15 7.8e-15
3 TCGA Breast Normal 0.04 0.019 7.8e-03 -0.001 0.005 -0.001 0.007 -0.001 9.9e-01 1.2e-02 6.3e-01 3.8e-03 9.6e-01
4 TCGA Prostate Tumor 0.05 0.022 5.1e-03 0.028 0.005 0.021 NA 0.024 1.7e-04 7.0e-02 9.7e-04 NA 4.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Alzheimer’s Disease (in mother) 0.5 0.5 1.5 -0.8 0.3 1.2 -0.1
Alzheimer’s Disease (in father) 0.4 0.4 1.5 -1.2 0.0 -0.3 0.3
Alzheimer’s Disease (including proxy) 0.7 1.0 1.8 -1.4 0.8 0.7 0.9
Crohns Disease (2017) 0.3 0.7 2.6 1.6 0.1 0.2 -0.2
Irritable Bowel Disease (IBD) 0.2 0.5 0.9 0.8 0.9 -0.6 -0.5
Ulcerative Colitis (UC) 0.5 0.9 1.6 -0.3 1.3 -1.3 -0.4
Major Depression (MDD) 2.0 2.5 7.9 -0.8 -1.1 -2.8 -0.5
Reaction Time 2.7 5.3 14.7 -2.5 -0.4 -0.0 3.8
Verbal and Numeric Reasoning (VNR) 1.1 2.7 6.8 1.0 1.3 2.6 1.2
Breast Cancer 0.2 0.5 0.9 0.9 0.2 -0.4 -0.9
Ovarian Cancer 0.8 1.0 2.6 1.6 -0.2 0.9 0.8
Prostate Cancer 1.0 1.4 4.8 -0.4 -2.2 -0.6 -0.3
Age at First Birth 0.3 0.4 0.7 0.3 0.5 0.8 0.8
Bipolar Disorder 1.1 1.1 2.7 -1.0 -0.6 1.6 -0.6
Body Mass Index (BMI) (2010) 1.1 1.6 3.6 0.6 1.9 1.3 0.8
Coronary Artery Disease (CAD) 1.8 2.2 7.7 -0.1 -1.1 -0.1 -2.8
Crohns Disease (2012) 0.6 0.9 2.5 -1.6 -0.9 -0.5 -0.2
Mean Putamen Volume 1.5 1.7 2.4 -1.6 -0.2 -1.5 1.4
Fasting Glucose 0.4 0.5 1.2 -0.0 -1.1 -0.6 0.8
HbA1C 1.6 1.8 5.0 0.4 -2.2 -0.8 -1.2
HDL Cholesterol 0.6 0.9 2.3 1.5 -1.0 -0.1 -0.6
LDL Cholesterol 0.5 0.8 2.6 0.2 1.6 -0.5 0.3
Lupus 0.1 0.2 0.3 0.6 0.4 0.3 -0.1
Neuroticism 4.4 6.5 15.7 -0.9 -2.3 -4.0 -2.1
Primary Biliary Cirrhosis 0.3 0.4 0.7 -0.8 -0.4 -0.4 -0.8
Rheumatoid Arthritis 0.2 0.2 0.6 -0.2 -0.2 -0.8 0.5
Schizophrenia 0.2 0.5 1.1 0.8 -0.3 -1.1 0.1
Triglycerides 0.9 1.4 2.6 0.2 -1.0 -1.4 -1.6
Type 2 Diabetes (T2D) 0.2 0.2 0.8 -0.1 0.9 0.1 0.3
Ulcerative Colitis 1.4 2.0 5.9 0.1 -2.4 -0.1 -1.5
Blood Eosinophil Count 0.3 2.2 5.7 1.4 -0.4 -0.9 -2.4
Blood Platelet Count 0.1 0.8 1.5 -0.8 1.2 0.9 -0.6
Blood Red Count 0.2 2.0 4.5 0.7 -1.6 -2.1 -0.9
Blood White Count 0.1 0.4 1.1 -0.3 -0.2 -1.0 0.7
Heel T-Score 0.1 0.6 2.0 0.3 -0.7 1.4 -0.0
BMI 0.5 2.8 5.6 2.4 1.7 1.6 -0.3
Height 0.4 8.8 26.1 0.8 1.1 5.1 2.7
Waist Hip Ratio (WHR) 2.3 10.5 34.7 -0.6 5.9 1.1 2.4
Systolic Blood Pressure 0.3 1.7 5.4 -2.3 -1.2 -0.3 -0.0
Smoking Status 0.5 1.3 3.1 1.4 -0.1 -0.1 -1.8
Allergy or Eczema 0.7 1.7 3.3 -1.7 -1.8 -0.5 -0.6
Cardiovascular Disease 1.4 4.6 11.9 -2.4 -0.8 -0.0 -3.4
Hypothyroidism (self reported) 0.5 1.2 3.2 1.8 -0.7 -0.1 -1.0
Respiratory disease 0.0 0.1 0.2 -0.5 0.0 -0.4 0.0
Type 2 Diabetes (T2D) 1.2 2.2 5.5 -0.2 1.3 -2.4 -1.1
Lung FEV1/FVC ratio 0.2 1.1 2.6 0.9 0.5 1.6 -0.9
Lung FVC 0.8 4.2 7.1 2.0 -2.7 0.1 -2.4
Neuroticism 4.5 11.0 29.6 -0.6 -3.2 -5.4 -1.9
Chronotype (morning person) 0.6 1.4 2.3 -1.1 1.5 -1.5 -0.2
Hair Pigment 0.0 0.5 1.3 -0.1 -1.1 -0.8 0.0
Tanning 0.1 1.7 3.4 1.4 -1.8 0.1 -1.2
Hand grip strength (left) 1.0 2.8 6.8 -2.6 0.9 -0.6 1.7
Number of treatments/medications taken 0.3 0.5 1.8 0.5 0.3 1.3 0.0
Average weekly spirits intake 0.5 0.7 1.3 0.1 -0.8 1.1 -0.8
Sensitivity / hurt feelings 3.1 5.5 15.9 1.0 2.0 4.0 1.1
Frequency of depressed mood in last 2 weeks 3.5 4.9 14.6 -1.2 3.8 1.7 0.8
Hearing difficulty/problems: Yes 0.4 0.6 2.1 -0.1 0.5 1.4 -0.4
Relative age of first facial hair 0.7 1.5 2.6 -0.9 -1.6 0.7 -1.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 0.0 -0.8 -0.6 -0.5
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.4 -1.8 -0.1 1.5 0.6
Ever had hysterectomy (womb removed) 0.7 0.8 2.8 -1.7 -0.4 -0.5 0.1
Systolic blood pressure, automated reading 0.1 0.4 1.7 1.3 0.0 -0.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.5 0.5 0.3 1.9 -0.2
Angina 0.3 0.4 1.4 0.5 -0.1 1.2 0.2
Medication for hormone replacement therapy 1.5 1.7 2.4 -1.4 1.0 1.6 1.2
Vitamin and mineral supplements 2.0 2.7 10.9 -0.2 -3.3 -0.1 -0.2
Supplements: Zinc 2.0 2.2 5.3 0.8 2.3 1.6 0.4
Medication: Co-codamol 0.9 1.0 2.0 -0.7 0.6 1.1 -1.4
Medication: Metformin 0.3 0.5 1.7 0.0 -0.5 1.3 0.1
Diabetes (father) 0.7 0.9 2.0 1.4 0.2 1.2 -0.2
Diabetes (mother) 0.3 0.3 0.8 0.2 -0.1 -0.7 0.9
Severe depression (siblings) 0.3 0.3 1.2 0.1 0.1 1.1 0.0
Pack years adult smoking proportion 0.6 0.9 1.9 -0.5 -1.1 1.4 0.3
Impedance of leg (right) 0.6 3.1 5.3 2.3 1.6 2.1 -0.2
Leg fat-free mass (left) 0.7 3.7 9.9 -2.2 -0.4 -3.1 0.2
Trunk fat percentage 0.6 2.3 4.0 -0.7 -2.0 -1.4 -1.7
Hand grip strength (right) 1.4 3.8 12.3 -3.5 0.8 -1.3 0.8
Townsend deprivation index at recruitment 0.3 0.4 0.7 0.0 0.6 0.9 0.7
Current tobacco smoking 0.4 0.6 1.3 -0.4 0.4 1.2 1.0
Average weekly fortified wine intake 0.9 1.1 2.2 1.5 -0.5 -1.4 0.1
Maternal smoking around birth 3.1 4.4 13.5 -3.7 -0.3 0.7 1.9
Fed-up feelings 4.1 7.7 18.1 -1.9 2.2 4.3 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 10.4 -0.2 3.2 1.1 0.4
Relative age voice broke 0.1 0.1 0.3 0.2 -0.2 -0.2 -0.6
Taking other prescription medications 0.2 0.4 1.2 0.3 -0.0 1.1 -0.5
Age when periods started (menarche) 0.6 1.3 2.7 1.6 -0.1 -0.2 -1.6
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 3.0 -1.7 -0.5 1.0 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.6 -0.8 0.5 0.4 0.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.2 0.6 1.1 0.7 -0.9
Qualifications: CSEs or equivalent 1.6 2.1 6.0 2.4 0.2 0.3 -1.5
Serious illness, injury or assault to yourself 0.8 1.0 1.9 -0.2 -1.4 -0.7 -1.2
High blood pressure 0.8 2.2 4.7 2.0 -0.1 -0.2 2.2
Hayfever, allergic rhinitis or eczema 1.4 3.1 6.1 2.2 2.5 0.8 1.0
Multivitamins +/- minerals 2.2 2.8 10.5 -0.3 3.2 0.2 0.6
Stomach or abdominal pain in last month 1.6 1.9 4.1 2.0 0.3 0.6 -1.8
Supplements: Glucosamine 0.7 0.9 2.1 -0.5 -0.8 0.6 -1.5
Diverticular disease/diverticulitis (self-reported) 2.4 2.9 6.3 -2.5 2.1 0.3 0.7
Medication: Atenolol 0.4 0.5 1.5 0.5 0.5 -1.2 -0.2
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.7 0.2 0.3 -0.3
Sitting height 0.5 3.7 10.0 1.0 3.2 -1.6 1.1
Chronic bronchitis/emphysema (father) 1.2 1.4 2.1 -0.7 1.3 1.2 1.4
High blood pressure (mother) 1.6 2.2 4.9 1.4 2.2 0.8 1.2
Body mass index (BMI) 0.5 2.3 5.7 -2.4 -1.1 -1.5 -0.3
Impedance of leg (left) 0.6 2.9 5.6 2.4 1.4 1.9 -0.7
Leg predicted mass (left) 0.7 3.7 9.9 -2.1 -0.4 -3.1 0.2
Trunk fat mass 0.5 2.4 4.8 -1.4 -1.3 -2.2 -1.1
Waist circumference 0.7 2.8 4.5 -1.9 -2.1 -1.6 -0.7
Number of incorrect matches in round 1.7 2.8 4.1 1.9 2.0 1.3 1.3
Past tobacco smoking 0.8 1.5 2.3 0.8 1.2 1.3 -1.5
Alcohol usually taken with meals 1.2 2.0 5.9 2.4 0.4 -0.1 -1.3
Nervous feelings 1.3 2.5 4.7 1.5 1.8 2.2 -0.1
Frequency of tenseness / restlessness in last 2 weeks 2.8 4.5 12.2 0.5 3.5 2.2 0.7
Hearing difficulty/problems with background noise 0.8 1.2 3.2 0.9 0.8 -0.6 -1.8
Hair/balding pattern: Pattern 2 1.6 2.0 3.6 1.8 -0.1 -1.1 -1.9
Had menopause 0.2 0.2 0.4 0.1 -0.6 -0.3 -0.6
Had other major operations 1.6 2.0 5.2 0.2 -1.6 -0.0 -2.3
Forced vital capacity (FVC) 0.3 1.3 1.6 -1.2 0.9 -1.1 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 -0.9 -0.1 -0.1 -0.5
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.2 -0.1 1.5 1.4 0.0
Qualifications: None of the above 1.6 3.5 11.9 1.1 0.9 3.5 0.2
Financial difficulties in last 2 years 1.5 2.0 3.7 1.0 1.9 1.9 -0.1
Mouth/teeth dental problems 0.7 1.1 3.7 -0.1 -0.7 -1.9 -0.4
Heart attack 0.3 0.3 0.6 -0.1 0.8 -0.8 0.3
Allergy 0.9 2.1 3.9 -2.0 -1.7 -1.2 -0.5
Pain all over the body in last month 0.8 0.8 2.2 -0.2 -0.8 -0.7 -1.5
Diabetes (self-reported) 0.4 0.6 1.6 -0.1 -0.3 1.3 1.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.4 1.5 0.6 0.5 0.1
Medication: Ramipril 1.0 1.3 4.3 0.8 -0.2 2.1 0.2
Medication: Simvastatin 0.7 1.0 3.5 0.4 0.3 0.6 1.9
Fluid intelligence score 0.7 1.4 4.4 -0.5 0.3 -2.1 -0.9
Illnesses of siblings 1.1 1.5 2.7 -1.6 -1.6 -0.9 -0.1
Neuroticism score 4.2 8.9 22.6 0.6 3.0 4.8 2.0
Weight 0.8 4.1 9.7 -2.4 -0.6 -3.1 -0.6
Impedance of arm (right) 1.4 6.5 15.1 3.9 -1.9 0.6 -2.7
Arm fat percentage (right) 0.6 2.3 4.1 -0.8 -2.0 -1.5 -1.5
Trunk fat-free mass 0.9 5.4 9.3 -3.0 1.5 -3.0 0.9
Hip circumference 0.3 1.2 3.0 -1.7 0.4 -1.2 -0.4
Time employed in main current job 0.5 0.6 1.5 -1.2 -0.8 0.5 0.1
Alcohol intake versus 10 years previously 2.2 3.2 8.7 -2.9 -0.1 0.2 2.1
Father’s age at death 2.5 3.4 8.5 1.3 -1.7 -0.5 -2.9
Worrier / anxious feelings 3.1 5.8 17.7 0.9 1.7 4.2 1.4
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 7.7 -0.9 1.7 2.8 0.1
Falls in the last year 0.8 1.1 3.1 0.6 0.3 -0.9 -1.8
Hair/balding pattern: Pattern 3 0.6 0.9 1.8 0.7 1.2 1.4 0.2
Number of live births 1.8 2.6 4.2 -0.1 1.7 2.1 1.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.3 -1.1 0.4 -1.5 0.9
Pulse rate 2.2 3.7 12.4 -0.2 1.4 -0.5 3.5
Happiness 0.4 0.4 1.4 0.2 0.5 1.2 -0.2
Noisy workplace 0.6 0.7 2.4 0.3 -0.6 1.6 -0.1
Qualifications: A levels/AS levels or equivalent 1.1 2.6 5.7 -0.1 -1.7 -2.4 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.6 -0.9 1.6 -0.7 0.4
Mouth/teeth dental problems: Dentures 1.6 2.8 7.3 -1.6 0.2 2.7 1.2
Asthma 0.1 0.2 0.8 0.2 0.1 0.9 -0.1
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.9 4.2 -1.2 1.1 0.6 2.1
Medication: Cholesterol lowering 0.8 1.3 2.1 1.5 0.8 0.8 1.3
Depression (self-reported) 0.6 0.7 1.5 0.5 0.2 0.9 -1.2
Medication: Lansoprazole 2.5 2.8 9.2 -3.0 -0.6 -0.1 -1.3
Prospective memory result 0.9 1.1 3.2 1.8 -0.1 1.2 0.1
Lung cancer (father) 0.6 0.7 1.7 -0.3 -0.1 1.3 1.0
Illnesses of mother 0.5 0.6 1.3 -0.9 -1.1 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.3 -1.1 0.2 -1.5 0.5
Pulse wave Arterial Stiffness index 2.2 2.5 5.1 -0.1 2.1 0.7 2.3
Impedance of arm (left) 1.2 5.5 9.6 3.1 -2.1 0.5 -2.8
Arm fat mass (right) 0.5 2.1 4.0 -2.0 -0.9 -1.8 -0.6
Trunk predicted mass 0.9 5.3 9.0 -3.0 1.6 -3.0 0.9
Standing height 0.3 3.2 11.8 -0.3 0.8 -3.4 -0.6
Length of working week for main job 1.8 2.0 3.3 -0.7 1.6 -1.2 1.8
Exposure to tobacco smoke at home 0.9 1.1 2.7 -0.3 0.2 1.2 1.6
Breastfed as a baby 0.5 0.6 1.6 1.3 0.5 -0.3 -0.7
Tense / ‘highly strung’ 1.4 2.4 4.0 2.0 1.4 1.9 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 5.5 -0.3 0.5 2.4 1.9
Hair/balding pattern: Pattern 4 1.6 4.0 12.9 -1.1 -3.6 -1.2 -0.4
Birth weight of first child 1.6 2.8 6.1 2.2 -0.7 0.2 -2.5
Peak expiratory flow (PEF) 0.5 1.2 2.4 -1.5 -0.3 -1.3 0.8
Pulse wave reflection index 0.7 0.9 1.7 -0.1 0.9 1.1 1.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.8 -0.9 -0.3 -0.5 0.5
Loud music exposure frequency 1.5 1.7 4.1 2.0 0.4 -1.4 -0.6
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.8 -0.4 -0.2 -0.5 -1.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 0.6 0.4 0.2 0.4
Blood clot in the leg (DVT) 0.2 0.2 0.6 0.8 -0.1 0.1 -0.5
Medication: Paracetamol 1.1 1.8 4.3 -0.3 -0.2 1.7 -2.1
Headache pain in last month 0.5 0.9 3.2 0.3 0.3 1.8 -0.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.2 2.7 -1.2 -1.0 -0.2 -1.6
Glaucoma (self-reported) 0.3 0.3 1.1 -0.2 -1.1 -0.1 0.2
Gout (self-reported) 0.9 1.2 3.2 -1.8 -0.4 0.3 1.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.9 -1.4 0.8 0.7 0.7
Medication: Amlodipine 0.2 0.3 0.6 -0.3 -0.7 -0.8 0.1
Medication: Ventolin 100micrograms inhaler 1.8 2.3 5.5 1.9 2.4 0.2 0.3
Birth weight 0.2 0.5 1.4 -0.5 0.5 0.2 1.2
Chronic bronchitis/emphysema (mother) 1.6 1.9 4.9 1.0 -1.0 0.9 -2.2
High blood pressure (siblings) 1.6 2.3 3.3 1.4 1.8 1.0 1.8
Forced vital capacity (FVC), Best measure 0.2 0.9 1.8 -0.7 0.8 -1.3 0.8
Body fat percentage 0.4 1.7 3.1 -0.9 -1.7 -1.1 -1.3
Leg fat percentage (right) 0.2 0.7 2.0 -1.4 -0.4 -0.7 -0.1
Arm fat-free mass (right) 1.1 5.5 11.2 -3.3 1.6 -2.6 1.1
Exposure to tobacco smoke outside home 0.5 0.7 1.5 -1.0 0.1 -0.4 -1.2
Comparative body size at age 10 2.4 6.8 12.9 -3.2 1.8 -0.8 3.6
Number of full brothers 0.5 0.6 0.8 0.6 0.8 0.9 -0.9
Worry too long after embarrassment 1.6 2.6 6.8 1.2 -0.3 2.6 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.1 0.6 -0.7 1.4 0.7
Wheeze or whistling in the chest in last year 0.8 1.5 3.5 1.3 -1.9 0.8 0.4
Number of children fathered 0.7 0.7 1.5 -0.9 -1.2 -0.3 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 1.5 1.1 -0.2 -0.4 1.2
Age at first live birth 1.1 1.9 4.1 2.0 -0.4 -1.8 -0.6
Pulse wave peak to peak time 2.4 2.8 5.9 -0.1 -2.1 -1.1 -2.4
Health satisfaction 0.3 0.4 0.7 0.6 0.8 0.8 -0.4
Shortness of breath walking on level ground 0.4 0.5 0.8 -0.4 -0.4 0.8 -0.9
Qualifications: College or University degree 1.6 5.1 19.8 0.4 -0.7 -4.5 0.0
Eye problems/disorders: None of the above 0.4 0.5 0.9 -1.0 0.9 0.2 -0.0
Mouth/teeth dental problems: Loose teeth 1.8 2.1 8.0 0.4 -2.8 0.3 -0.6
Emphysema/chronic bronchitis 1.1 1.3 1.9 1.4 -1.3 0.1 -1.2
Medication for pain relief, constipation, heartburn 0.6 1.0 3.5 0.5 -0.5 -1.9 0.5
Neck or shoulder pain in last month 0.4 0.5 1.5 0.4 0.3 1.2 -0.6
Medication: Blood pressure 0.6 1.0 1.7 1.3 0.8 -0.5 1.2
Angina (self-reported) 0.4 0.5 1.4 0.6 -0.1 1.2 0.3
Migraine (self-reported) 0.4 0.5 0.6 -0.6 -0.5 0.8 0.7
Medication: Ibuprofen 1.9 2.3 4.7 -1.0 1.6 0.8 2.2
Medication: Allopurinol 0.5 0.7 1.9 -0.8 -1.4 -0.1 0.1
Medication: Omeprazole 0.9 1.0 3.6 0.5 -0.3 1.9 -0.2
Medication: Seretide 50 evohaler 0.8 0.9 1.7 1.3 -1.0 0.2 -1.0
Mean time to correctly identify matches 4.2 8.0 21.7 3.2 -0.5 0.2 -4.7
Heart disease (mother) 0.6 0.8 2.8 -1.7 0.5 0.1 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.9 -1.7 0.4 0.1 0.9
Whole body fat mass 0.5 2.0 3.7 -1.6 -1.1 -1.9 -0.7
Leg fat mass (right) 0.4 1.5 3.7 -1.9 -0.3 -1.6 0.1
Arm predicted mass (right) 1.0 5.2 11.4 -3.4 1.4 -2.6 0.9
Pulse rate, automated reading 2.6 8.5 26.3 -0.1 2.5 -1.3 5.1
Alcohol intake frequency. 0.3 0.8 1.7 0.6 -1.3 -0.1 -1.1
Comparative height size at age 10 0.7 4.1 15.5 -0.5 0.7 -3.9 0.2
Number of full sisters 0.3 0.3 1.0 1.0 0.1 -0.3 -0.4
Suffer from ‘nerves’ 3.2 5.0 13.5 1.2 2.2 3.7 -0.5
Overall health rating 1.6 3.5 8.3 1.5 -0.3 1.8 -2.9
Chest pain or discomfort 2.1 3.1 5.9 1.8 -1.7 0.8 -2.4
Had major operations 1.4 1.7 2.8 -1.1 1.6 -0.5 1.7
Age at last live birth 0.7 1.1 3.2 1.8 -0.9 -0.3 0.4
Family relationship satisfaction 0.7 0.8 2.5 0.4 0.7 1.6 -0.0
Leg pain on walking 0.8 1.0 1.7 0.8 -1.2 0.4 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.6 -1.0 -0.2 -0.4 -1.3
Commuting to job workplace: Car/motor vehicle 2.6 3.0 4.5 -2.1 1.1 1.4 2.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.4 1.2 -0.1 0.3 0.2
Medication: Aspirin 1.9 2.5 7.6 0.9 0.9 2.8 0.9
Supplements: Vitamin C 2.4 2.8 9.9 3.1 1.1 -0.2 -0.5
Knee pain experienced in last month 0.2 0.3 0.6 -0.3 -0.4 0.6 0.7
Hypertension (Self-reported) 0.8 2.4 5.7 1.9 0.2 0.3 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.7 1.3 -1.2 -0.1 -0.8
Illnesses of father: Heart disease 0.5 0.6 1.1 -1.1 0.8 -0.4 0.7
Illnesses of siblings: Diabetes 2.0 2.5 5.0 0.3 2.2 2.1 0.5
Smoking status: Previous 0.8 1.3 2.1 -0.3 -1.1 -1.3 1.5
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 6.6 -0.8 -1.0 -2.6 -0.9
Whole body fat-free mass 0.8 4.7 9.9 -2.8 1.0 -3.1 0.6
Leg fat-free mass (right) 0.7 4.0 11.8 -2.0 -0.5 -3.4 -0.1
Arm fat percentage (left) 0.7 2.8 4.8 -1.2 -2.2 -1.7 -1.5
Average weekly red wine intake 1.5 2.3 4.5 1.0 -2.1 -1.1 -1.5
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.8 0.9 0.6 -0.2 0.3
Mood swings 2.1 3.9 7.1 -0.8 1.7 2.7 2.3
Loneliness, isolation 0.6 0.9 2.4 -1.6 0.6 -0.8 0.2
Long-standing illness, disability or infirmity 0.4 0.6 1.1 -0.2 -1.1 -0.5 -0.9
Ever had bowel cancer screening 0.2 0.3 0.5 -0.0 -0.7 0.5 -0.6
Diabetes diagnosed by doctor 0.4 0.7 1.2 0.5 -0.8 0.8 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.5 0.7 -0.5 -0.6 -0.6
Friendships satisfaction 0.5 0.7 1.2 -0.3 -0.8 1.1 -0.8
Qualifications: nursing, teaching 1.0 1.6 3.9 -0.5 -1.0 -2.0 -1.1
Commuting to job workplace: Walk 0.6 0.6 1.3 0.6 1.1 0.3 -0.8
Eye problems/disorders: Cataract 1.3 1.6 3.9 0.8 -2.0 -0.8 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.7 0.8 0.0 0.6 -0.2
Medication for cholesterol 0.4 0.6 1.3 0.5 -0.5 -0.8 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.4 -2.1 1.1 1.2 0.5
Back pain experienced in last month 0.3 0.5 1.2 0.3 0.6 1.1 -0.4
Mineral and other dietary supplements 0.9 1.2 2.9 -0.3 -1.7 -1.1 0.9
Breast cancer (self-reported) 0.3 0.3 1.0 -0.4 -0.2 -0.4 -1.0
Asthma (self-reported) 0.1 0.2 0.5 0.3 -0.0 0.7 -0.5
Osteoporosis (self-reported) 1.1 1.4 2.3 1.5 1.2 -1.4 -0.0
Osteoarthritis (self-reported) 0.7 0.9 1.6 -0.9 -0.8 0.6 -1.3
Medication: Aspirin 2.0 2.6 7.8 0.8 1.2 2.8 0.7
Medication: Gliclazide 0.6 0.6 1.1 -1.1 0.5 1.1 -0.3
Illnesses of father: None of the above (group 1) 1.0 1.2 1.9 -1.3 -0.3 -1.1 -1.4
Smoking status: Current 0.4 0.7 1.1 -0.7 0.3 1.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.3 -1.4 -0.4 -0.7 1.5
Whole body water mass 0.8 4.6 9.7 -2.7 1.0 -3.1 0.6
Leg predicted mass (right) 0.7 4.0 11.8 -1.9 -0.6 -3.4 -0.1
Arm fat mass (left) 0.5 2.3 3.6 -1.9 -1.1 -1.9 -0.8
Number of self-reported non-cancer illnesses 0.5 0.9 1.8 1.2 -0.2 0.6 1.3
Average weekly champagne plus white wine intake 0.5 0.7 1.3 0.8 0.8 0.5 1.2
Miserableness 1.0 1.8 6.6 -0.5 0.3 2.6 0.3
Guilty feelings 3.2 4.9 14.5 -0.0 1.7 3.8 1.4
Wears glasses or contact lenses 1.4 1.6 2.6 1.4 -1.6 -1.0 -1.0
Ever taken oral contraceptive pill 0.2 0.2 0.5 0.7 0.5 0.3 0.2
Hearing aid user 0.9 1.0 2.6 -1.0 0.5 1.6 0.4
Mother’s age at death 0.1 0.1 0.5 0.0 0.7 -0.1 -0.1
Financial situation satisfaction 2.7 3.3 7.3 0.5 1.9 2.7 -1.4
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.1 1.5 -0.9 0.9 0.4
Commuting to job workplace: Public transport 1.1 1.4 5.2 0.4 0.3 -2.3 -0.2
Eye problems/disorders: Glaucoma 0.2 0.3 0.4 0.4 -0.4 0.6 0.7
Medication: Blood pressure 0.4 0.7 1.4 1.2 -1.1 -0.1 0.7
Pain type(s) experienced in last month: Hip pain 1.7 2.2 5.5 -0.5 -2.3 -1.7 -0.6
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.3 -1.0 1.2 0.5 -0.2
High cholesterol (Self-reported) 0.3 0.5 2.0 0.0 0.2 -0.3 1.4
Medication: Bendroflumethiazide 0.6 0.9 1.5 -1.1 0.3 0.9 1.2
Medication: Paracetamol 0.8 1.2 3.0 -0.0 -0.1 1.4 -1.7
Medication: Lisinopril 1.3 1.7 4.1 0.7 -0.8 -1.3 2.0
Medication: Atorvastatin 0.5 0.6 1.2 -0.7 0.2 -0.8 -1.1
Illnesses of father: High blood pressure 0.5 0.6 1.3 0.7 0.3 0.6 1.2
Alcohol drinker status: Never 0.1 0.1 0.1 -0.2 -0.4 0.3 0.1
Ever smoked 0.2 0.4 0.8 0.5 -0.2 -0.9 0.7
Basal metabolic rate 0.8 4.4 9.9 -2.7 0.6 -3.2 0.5
Leg fat percentage (left) 0.2 0.7 1.8 -1.3 -0.5 -0.6 -0.5
Arm fat-free mass (left) 0.8 4.3 6.9 -2.6 1.7 -2.6 0.9
Number of operations (self-reported) 0.2 0.3 0.8 -0.4 -0.3 -0.3 0.9
Average weekly beer plus cider intake 0.7 1.1 3.7 -1.9 0.3 -0.2 0.7
Irritability 3.2 5.4 11.1 -0.7 2.5 1.9 3.3
Risk taking 0.7 1.0 2.7 -0.2 -0.1 -1.1 1.6
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.1 -0.2 -0.6 -0.4
Fractured/broken bones in last 5 years 0.7 0.9 2.1 0.0 1.2 0.1 1.4
Age started oral contraceptive pill 0.3 0.3 0.7 0.8 0.4 0.2 -0.6
Diastolic blood pressure, automated reading 0.6 1.8 5.5 0.1 -1.0 -2.3 0.9
Ever depressed for a whole week 2.5 3.2 6.6 0.6 2.6 1.8 1.5
Unable to work because of sickness or disability 0.3 0.4 1.2 -1.1 -0.6 0.5 -0.2
Commuting to job workplace: Cycle 1.3 1.5 3.9 -1.3 0.6 -2.0 -0.4
Myopia 0.9 1.3 2.4 -1.5 -1.6 -0.6 0.3
Vascular/heart problems diagnosed by doctor 1.0 2.7 5.3 -2.3 -0.3 -0.2 -2.3
Cholesterol lowering medication 0.2 0.3 0.5 -0.5 -0.6 0.4 0.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 0.3 -0.8 1.0 -0.6
Pain experienced in last month 1.4 2.3 6.8 -0.8 0.8 1.1 2.6
Supplements: Calcium 0.3 0.4 0.6 0.7 -0.6 0.7 -0.2
Basal cell carcinoma (self-reported) 0.7 0.9 1.2 -0.4 1.1 1.1 1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.9 -0.4 0.8 -0.9 0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.2 1.1 -0.2 0.3 -0.0
Heart disease (siblings) 0.6 0.8 1.9 -0.3 0.9 1.4 0.4
Alcohol drinker status: Previous 0.6 0.7 1.4 0.5 -0.7 1.2 -0.8
Pack years of smoking 0.7 1.1 2.5 -0.3 -1.3 1.6 0.1
Impedance of whole body 0.9 4.5 11.2 3.3 -0.7 1.5 -2.0
Leg fat mass (left) 0.4 1.5 3.4 -1.8 -0.4 -1.6 -0.1
Arm predicted mass (left) 0.9 4.4 8.0 -2.8 1.8 -2.4 0.9