Hub : Genes

KIAA1598

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.28 0.065 3.2e-05 0.049 NA 0.038 NA 0.043 1.0e-03 NA 3.6e-03 NA 2.0e-03
2 GTEx Artery Tibial 0.07 0.031 7.5e-03 0.025 NA 0.009 NA 0.024 4.7e-03 NA 6.4e-02 NA 5.1e-03
3 GTEx Cells Transformed fibroblasts 0.20 0.048 3.2e-08 0.211 NA 0.215 NA 0.215 8.5e-16 NA 4.7e-16 NA 4.4e-16
4 GTEx Lung 0.10 0.037 2.1e-03 0.097 NA 0.087 NA 0.094 7.3e-08 NA 3.7e-07 NA 1.2e-07
5 GTEx Spleen 0.28 0.092 6.8e-03 -0.007 NA -0.003 NA -0.010 5.2e-01 NA 3.8e-01 NA 7.5e-01
6 GTEx Thyroid 0.08 0.031 3.0e-03 0.072 NA 0.032 NA 0.056 3.5e-06 NA 1.6e-03 NA 4.1e-05
7 GTEx Whole Blood 0.26 0.050 4.0e-12 0.219 NA 0.201 NA 0.208 6.3e-20 NA 2.8e-18 NA 5.7e-19
8 METSIM Adipose 0.07 0.016 1.5e-10 0.106 0.073 0.092 0.083 0.098 1.3e-15 5.1e-11 1.3e-13 2.0e-12 2.0e-14
9 NTR Blood 0.12 0.017 0.0e+00 0.196 0.150 0.186 0.143 0.190 4.5e-61 5.1e-46 8.1e-58 7.9e-44 3.3e-59
10 YFS Blood 0.39 0.028 0.0e+00 0.635 0.610 0.637 0.634 0.634 1.7e-278 4.9e-260 1.0e-279 1.9e-277 9.1e-278
11 TCGA Breast Normal 0.02 0.010 6.1e-04 0.013 0.011 0.009 NA 0.012 1.8e-04 5.7e-04 1.5e-03 NA 2.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Alzheimer’s Disease (in mother) 0.3 0.4 1.8 0.5 -0.2 -1.2 -0.4 -0.4 0.5 -0.3 -0.3 -0.3 -0.3 -1.3
Alzheimer’s Disease (in father) 3.2 3.5 5.7 -1.1 -1.7 -2.4 -1.7 -2.2 2.1 -1.7 -1.7 -1.8 -1.8 -2.0
Alzheimer’s Disease (including proxy) 2.6 3.7 6.8 -0.9 -1.7 -2.6 -1.8 -2.2 1.9 -1.8 -1.8 -1.8 -1.8 -2.3
Crohns Disease (2017) 2.4 5.3 6.3 1.6 2.5 2.3 2.4 2.3 -2.5 2.5 2.3 2.4 2.4 2.0
Irritable Bowel Disease (IBD) 2.7 6.5 9.1 1.7 2.8 2.3 2.6 3.0 -2.5 2.6 2.4 2.7 2.7 2.5
Ulcerative Colitis (UC) 1.9 3.6 5.4 1.1 2.2 1.6 1.9 2.3 -1.7 1.8 1.7 2.0 2.0 2.1
Major Depression (MDD) 0.5 0.6 1.9 0.4 0.8 0.9 0.8 0.7 -0.5 0.7 0.7 0.6 0.8 1.4
Reaction Time 0.1 0.1 0.9 1.0 -0.0 -0.5 -0.0 -0.2 0.1 0.0 -0.0 0.1 0.1 -0.0
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.3 -0.0 0.2 0.2 0.1 0.3 0.2 0.0 -0.1 0.2 -0.0 0.5
Breast Cancer 0.1 0.2 1.7 -1.3 -0.2 -0.4 0.1 -0.3 0.2 0.2 0.3 -0.1 0.1 -0.2
Ovarian Cancer 0.1 0.1 0.5 -0.4 -0.0 -0.2 -0.4 -0.7 -0.1 -0.3 -0.2 -0.2 -0.2 -0.3
Prostate Cancer 0.1 0.1 0.6 -0.0 -0.8 -0.2 -0.5 0.2 0.3 -0.4 -0.1 -0.5 -0.3 -0.1
Age at First Birth 8.1 11.9 15.3 -2.9 -3.7 -3.7 -3.4 -3.1 3.4 -3.2 -3.4 -3.7 -3.4 -3.9
Bipolar Disorder 0.6 0.6 1.1 -0.7 -0.9 -0.7 -0.9 -0.0 1.0 -1.0 -0.9 -0.8 -0.7 -0.1
Body Mass Index (BMI) (2010) 7.6 10.6 12.8 3.0 3.6 2.7 3.3 3.2 -3.3 3.3 3.1 3.5 3.4 3.3
Coronary Artery Disease (CAD) 0.1 0.1 0.3 0.0 0.1 0.3 0.1 -0.6 -0.2 0.1 0.2 0.3 0.1 -0.5
Crohns Disease (2012) 0.1 0.1 0.4 0.4 -0.3 0.1 0.0 -0.3 0.6 -0.2 -0.1 -0.2 -0.3 -0.2
Mean Putamen Volume 9.2 10.6 14.4 1.7 3.4 3.2 3.4 3.2 -3.2 3.2 3.1 3.6 3.4 3.8
Fasting Glucose 1.5 1.8 2.6 1.1 1.3 1.1 1.4 1.6 -1.2 1.4 1.5 1.4 1.3 1.2
HbA1C 0.8 0.9 1.6 -1.2 1.1 0.5 1.0 0.7 -0.7 1.0 1.1 1.2 0.9 0.0
HDL Cholesterol 5.5 9.1 12.6 -2.8 -2.9 -3.1 -3.0 -3.6 3.2 -3.0 -3.2 -2.9 -3.1 -2.5
LDL Cholesterol 0.9 1.4 3.4 1.0 1.0 1.2 1.1 1.8 -0.7 0.9 1.0 1.2 1.2 1.3
Lupus 1.9 2.9 4.2 -1.4 -2.1 -1.8 -1.9 -1.6 1.4 -1.5 -1.5 -1.8 -1.5 -2.0
Neuroticism 0.5 0.7 2.5 0.6 0.6 1.4 0.4 1.6 -0.4 0.3 0.4 0.4 0.3 1.3
Primary Biliary Cirrhosis 0.2 0.2 0.9 0.3 0.4 0.0 0.6 -0.1 -0.3 0.6 0.9 0.6 0.5 -0.0
Rheumatoid Arthritis 1.7 2.4 4.6 -1.4 -1.2 -1.4 -1.6 -2.1 1.3 -1.6 -1.4 -1.5 -1.7 -1.6
Schizophrenia 0.1 0.3 0.8 -0.0 0.2 0.5 0.5 0.6 -0.4 0.5 0.4 0.6 0.5 0.9
Triglycerides 2.2 3.6 4.8 1.4 1.9 2.2 2.1 1.1 -1.8 1.9 2.1 2.1 2.1 1.8
Type 2 Diabetes (T2D) 0.3 0.4 1.6 1.3 0.3 0.0 0.4 0.4 -0.6 0.5 0.3 0.1 0.4 1.0
Ulcerative Colitis 0.2 0.3 1.4 1.2 -0.3 0.0 -0.0 -1.1 0.0 0.0 0.2 -0.2 -0.1 -0.6
Blood Eosinophil Count 0.3 2.6 5.2 1.4 1.9 1.4 1.6 1.4 -1.3 1.6 1.5 1.4 1.6 2.3
Blood Platelet Count 0.0 0.1 0.3 0.2 0.1 -0.2 -0.1 -0.4 0.4 -0.1 -0.1 -0.1 -0.1 0.6
Blood Red Count 0.5 4.8 8.3 2.6 2.2 2.2 1.9 2.9 -2.2 1.9 1.9 1.9 2.0 2.2
Blood White Count 0.6 4.8 7.2 1.4 2.5 2.4 2.1 1.8 -2.4 2.0 2.0 2.1 2.3 2.7
Heel T-Score 0.0 0.3 1.3 -1.0 -0.3 -0.6 -0.3 -1.2 0.4 -0.2 -0.5 -0.4 -0.4 -0.1
BMI 8.0 47.8 53.5 6.8 7.3 6.8 7.0 6.4 -7.1 6.9 6.6 7.0 7.1 7.0
Height 0.1 2.8 4.2 0.4 1.9 1.5 1.8 0.1 -1.9 1.9 2.0 1.9 2.0 1.7
Waist Hip Ratio (WHR) 0.3 1.4 13.5 -1.0 -0.1 0.3 0.1 -3.7 -0.2 0.2 0.1 0.0 0.3 1.0
Systolic Blood Pressure 0.3 1.3 2.6 -1.3 -1.6 -0.1 -1.3 -1.0 0.6 -1.2 -1.2 -1.3 -1.2 -1.2
Smoking Status 6.9 16.7 21.9 3.6 4.2 4.6 4.3 2.7 -4.1 4.2 3.9 4.2 4.2 4.7
Allergy or Eczema 0.2 0.4 0.8 -0.5 -0.7 -0.8 -0.7 -0.0 0.2 -0.6 -0.7 -0.7 -0.6 -0.9
Cardiovascular Disease 0.2 0.5 1.9 -0.1 0.8 1.4 0.7 0.3 -1.0 0.7 0.4 0.6 0.6 0.7
Hypothyroidism (self reported) 0.1 0.2 1.2 0.4 0.0 -0.9 -0.3 1.1 0.4 -0.2 0.0 -0.2 -0.2 -0.2
Respiratory disease 0.1 0.3 1.0 1.0 0.0 0.3 0.4 -0.1 -0.6 0.5 0.3 0.3 0.5 0.8
Type 2 Diabetes (T2D) 1.5 2.8 3.7 1.4 1.9 1.6 1.8 0.8 -1.6 1.8 1.8 1.8 1.7 1.9
Lung FEV1/FVC ratio 0.6 2.8 5.2 1.1 1.8 2.1 1.6 2.3 -1.6 1.6 1.2 1.6 1.4 1.6
Lung FVC 4.1 21.3 27.8 -2.8 -4.8 -4.7 -4.9 -3.0 5.3 -5.0 -4.8 -4.9 -5.0 -4.9
Neuroticism 0.3 0.6 6.2 -0.2 0.0 0.0 -0.2 2.5 0.3 -0.2 -0.2 -0.2 -0.1 0.6
Chronotype (morning person) 0.0 0.1 0.9 0.1 0.0 0.2 0.1 0.0 -0.3 0.1 0.1 0.1 -0.0 -1.0
Hair Pigment 0.0 0.6 4.0 0.2 0.7 0.1 0.3 -2.0 -0.9 0.5 0.6 0.4 0.6 0.4
Tanning 0.1 1.4 4.5 -2.1 -0.7 -1.2 -0.8 -0.9 1.2 -0.8 -1.1 -1.0 -1.1 -1.4
Hand grip strength (left) 2.4 6.4 10.4 2.6 2.1 2.5 2.5 2.1 -2.4 2.5 2.6 2.4 2.7 3.2
Number of treatments/medications taken 0.7 1.2 1.6 1.1 1.2 1.1 1.2 0.5 -1.1 1.1 1.2 1.3 1.3 1.0
Average weekly spirits intake 1.9 2.4 7.7 -0.3 -1.5 -1.7 -1.6 -0.8 1.1 -1.6 -1.5 -1.4 -1.6 -2.8
Sensitivity / hurt feelings 0.3 0.5 1.1 1.0 0.7 0.7 0.6 -0.1 -0.8 0.6 0.7 0.7 0.8 0.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 2.6 -0.1 0.1 0.6 0.0 -1.6 -0.1 -0.0 0.1 0.1 0.0 -0.2
Hearing difficulty/problems: Yes 1.4 2.1 3.4 -0.6 -1.8 -1.7 -1.4 -1.6 1.8 -1.4 -1.3 -1.5 -1.4 -1.1
Relative age of first facial hair 1.5 3.2 5.6 1.6 1.8 2.1 1.8 2.4 -1.9 1.7 1.5 1.7 1.7 1.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.6 1.6 1.2 0.7 1.1 0.9 -1.4 1.2 1.3 1.2 1.3 1.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.2 -0.7 -0.4 -0.2 -0.3 -1.1 0.3 -0.3 -0.4 -0.3 -0.3 0.2
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 0.1 0.4 0.3 0.4 0.1 -0.0 0.3 0.3 0.3 0.5 0.6
Systolic blood pressure, automated reading 0.1 0.3 1.0 -0.4 -0.3 -0.8 -0.5 -0.5 1.0 -0.6 -0.6 -0.4 -0.6 -0.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.8 0.4 -0.3 -0.2 -0.0 0.9 0.8 -0.2 -0.0 -0.2 -0.2 -0.3
Angina 0.4 0.5 1.1 0.4 0.8 1.0 0.7 -0.5 -0.8 0.5 0.8 0.7 0.6 0.3
Medication for hormone replacement therapy 0.0 0.0 0.1 0.0 -0.0 -0.1 -0.0 0.2 -0.1 -0.0 -0.1 0.0 0.1 -0.2
Vitamin and mineral supplements 2.0 2.8 4.4 0.4 2.1 1.6 1.9 1.0 -1.4 1.8 1.8 1.8 1.8 2.1
Supplements: Zinc 1.6 1.8 2.5 -1.4 -1.2 -1.5 -1.1 -1.5 1.6 -1.2 -1.1 -1.3 -1.3 -1.4
Medication: Co-codamol 0.3 0.3 0.8 0.4 -0.4 -0.6 -0.7 0.2 0.2 -0.5 -0.3 -0.6 -0.7 -0.9
Medication: Metformin 0.1 0.2 0.6 0.3 0.3 0.8 0.3 0.4 -0.8 0.3 0.3 0.4 0.3 -0.2
Diabetes (father) 0.9 1.1 2.2 -1.5 -0.6 -1.1 -1.0 -1.0 1.2 -1.1 -1.0 -1.0 -1.1 -0.9
Diabetes (mother) 0.7 0.9 2.3 0.2 -1.1 -1.1 -0.9 -0.6 1.0 -0.9 -0.8 -0.8 -0.9 -1.5
Severe depression (siblings) 0.8 0.9 2.3 1.2 0.3 1.5 0.6 1.1 -1.4 0.7 0.8 0.6 0.8 1.0
Pack years adult smoking proportion 0.5 0.7 1.6 -0.6 -0.8 -0.9 -0.8 -1.1 0.6 -0.8 -0.7 -0.7 -0.9 -1.3
Impedance of leg (right) 1.8 8.8 11.8 2.9 2.9 3.0 2.9 3.4 -3.0 2.8 2.7 2.9 2.9 3.1
Leg fat-free mass (left) 4.3 23.3 27.8 -4.6 -5.1 -4.8 -4.9 -4.1 5.3 -4.9 -4.8 -4.9 -5.0 -4.6
Trunk fat percentage 6.3 25.9 30.7 -4.8 -5.4 -4.7 -5.3 -3.8 5.5 -5.4 -5.2 -5.3 -5.4 -4.9
Hand grip strength (right) 1.3 3.7 9.3 1.5 1.5 2.2 1.9 1.6 -1.4 1.8 2.0 1.8 1.9 3.1
Townsend deprivation index at recruitment 3.2 4.5 7.5 -1.5 -2.3 -2.3 -2.2 -1.8 2.0 -2.1 -1.9 -2.1 -2.2 -2.7
Current tobacco smoking 1.2 2.0 3.9 -1.3 -1.4 -2.0 -1.5 -0.3 1.2 -1.3 -1.2 -1.3 -1.5 -1.9
Average weekly fortified wine intake 0.4 0.5 1.7 0.5 0.5 0.6 0.7 -0.3 -0.7 0.7 0.8 0.7 0.7 1.3
Maternal smoking around birth 0.6 0.9 1.6 0.5 0.8 1.3 0.8 1.2 -1.2 0.8 1.0 0.8 1.0 0.7
Fed-up feelings 0.8 1.5 4.4 -1.4 -1.1 -0.8 -1.1 -2.1 1.0 -1.2 -1.0 -1.0 -1.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.4 -0.7 -1.2 -1.1 -1.2 -1.4 1.2 -1.2 -1.1 -1.1 -1.2 -2.1
Relative age voice broke 1.9 3.0 6.0 0.9 1.7 2.4 1.7 1.5 -2.4 1.7 1.6 1.7 1.8 1.2
Taking other prescription medications 0.6 0.9 2.2 1.5 1.2 0.8 1.0 0.3 -1.0 1.0 0.8 1.0 1.0 0.5
Age when periods started (menarche) 2.2 5.3 8.5 2.9 2.2 2.4 2.4 1.3 -2.7 2.3 2.2 2.2 2.4 2.0
Bilateral oophorectomy (both ovaries removed) 5.4 6.2 9.2 1.6 2.5 3.0 2.7 1.4 -2.5 2.5 2.7 2.6 2.7 2.6
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.4 0.2 -0.2 -0.3 -0.2 -0.6 0.5 -0.2 -0.0 -0.2 -0.2 -0.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 -0.1 -0.4 -0.5 -0.4 -0.4 0.9 -0.6 -0.3 -0.4 -0.6 -0.2
Qualifications: CSEs or equivalent 0.2 0.2 1.0 -0.9 0.1 -0.6 0.0 -1.0 0.3 0.1 0.2 -0.1 0.0 0.4
Serious illness, injury or assault to yourself 0.8 1.0 1.6 0.6 1.3 0.5 1.1 0.7 -1.1 1.1 1.1 1.2 1.2 0.7
High blood pressure 0.0 0.1 0.7 0.4 -0.0 -0.2 0.0 0.8 0.3 -0.0 0.1 0.1 0.1 -0.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 -0.0 0.3 0.7 0.5 -0.1 -0.0 0.4 0.6 0.5 0.4 0.8
Multivitamins +/- minerals 4.9 6.2 8.5 -1.1 -2.8 -2.6 -2.7 -1.0 2.5 -2.8 -2.6 -2.6 -2.8 -2.9
Stomach or abdominal pain in last month 0.3 0.4 1.0 0.3 -0.9 -0.6 -0.7 -1.0 0.5 -0.5 -0.3 -0.7 -0.5 -0.2
Supplements: Glucosamine 0.5 0.7 1.6 -0.6 -0.6 -0.7 -0.8 -1.2 0.9 -0.8 -0.7 -0.8 -0.9 -0.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 2.4 -1.6 -0.4 -0.2 -0.4 -0.1 0.6 -0.6 -0.4 -0.5 -0.6 -0.4
Medication: Atenolol 0.1 0.2 0.8 0.9 -0.2 -0.8 -0.1 -0.3 0.3 -0.0 -0.0 -0.1 0.0 -0.4
Medication: Levothyroxine sodium 0.2 0.3 2.3 -0.4 -0.4 -0.1 -0.3 -1.5 0.1 -0.3 -0.5 -0.2 -0.3 -0.4
Sitting height 0.1 0.6 1.1 -0.3 -1.0 -0.7 -0.8 -0.4 1.0 -0.9 -0.9 -0.8 -0.9 -0.1
Chronic bronchitis/emphysema (father) 1.9 2.2 2.9 -1.6 -1.5 -1.7 -1.6 -0.8 1.3 -1.6 -1.7 -1.5 -1.4 -1.3
High blood pressure (mother) 0.7 0.9 1.8 0.4 1.3 0.2 1.1 0.3 -0.7 1.1 1.2 1.1 1.1 1.2
Body mass index (BMI) 8.3 36.5 41.1 -5.9 -6.4 -5.6 -6.2 -5.4 6.3 -6.1 -5.9 -6.1 -6.2 -6.1
Impedance of leg (left) 1.9 9.2 12.6 3.0 3.0 3.0 3.0 3.6 -3.1 2.9 2.8 2.9 2.9 3.1
Leg predicted mass (left) 4.2 22.6 27.1 -4.5 -5.0 -4.7 -4.8 -4.0 5.2 -4.8 -4.8 -4.8 -5.0 -4.5
Trunk fat mass 7.6 33.4 38.8 -5.4 -6.2 -5.4 -6.0 -4.4 6.2 -6.0 -5.9 -6.0 -6.1 -5.7
Waist circumference 9.3 34.8 39.7 -5.4 -6.3 -5.6 -6.2 -4.0 6.2 -6.2 -5.9 -6.1 -6.3 -6.3
Number of incorrect matches in round 3.3 5.6 6.8 2.1 2.6 2.4 2.6 1.2 -2.4 2.4 2.5 2.6 2.6 2.2
Past tobacco smoking 6.0 11.3 13.8 2.5 3.5 3.4 3.5 2.9 -3.4 3.5 3.4 3.5 3.4 3.7
Alcohol usually taken with meals 0.9 1.4 2.4 1.6 1.0 1.4 1.4 -0.1 -0.8 1.3 1.1 1.2 1.1 1.3
Nervous feelings 2.6 4.9 6.7 1.1 2.2 2.1 2.4 0.2 -2.6 2.5 2.6 2.4 2.6 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 3.1 -0.5 -0.6 -0.2 -0.4 -1.8 0.4 -0.5 -0.2 -0.5 -0.5 -1.3
Hearing difficulty/problems with background noise 0.1 0.1 0.5 0.7 -0.4 -0.2 0.1 -0.7 0.4 0.0 0.1 0.0 0.0 -0.4
Hair/balding pattern: Pattern 2 0.3 0.3 1.2 -0.5 -0.7 -0.3 -0.4 0.4 0.5 -0.5 -0.6 -0.5 -0.5 -1.1
Had menopause 0.2 0.2 1.0 1.0 0.2 0.4 0.2 0.1 -0.6 0.3 0.1 0.3 0.3 0.6
Had other major operations 0.9 1.1 2.0 0.1 1.2 0.5 1.2 0.1 -1.1 1.3 1.4 1.2 1.4 0.9
Forced vital capacity (FVC) 1.5 6.0 8.9 1.0 2.7 2.5 2.7 1.8 -2.4 2.6 2.5 2.6 2.7 3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.2 -0.6 -0.9 -0.7 -0.8 -0.2 1.1 -0.8 -0.6 -0.8 -0.8 -0.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 0.4 0.3 0.1 0.3 0.0 -0.4 0.2 0.4 0.4 0.3 -0.2
Qualifications: None of the above 1.8 3.8 6.8 -2.6 -1.9 -1.3 -2.0 -1.3 1.9 -2.1 -2.1 -1.9 -2.0 -2.0
Financial difficulties in last 2 years 6.0 8.1 14.9 -2.0 -3.0 -2.7 -3.0 -1.8 2.5 -2.9 -2.9 -3.0 -3.0 -3.9
Mouth/teeth dental problems 1.3 2.0 2.6 1.0 1.5 1.2 1.6 1.0 -1.4 1.6 1.6 1.5 1.5 1.4
Heart attack 1.5 1.9 2.9 0.9 1.3 0.6 1.6 1.0 -1.4 1.6 1.6 1.6 1.7 1.3
Allergy 0.1 0.1 0.3 0.5 -0.3 -0.3 -0.4 0.6 -0.3 -0.2 -0.4 -0.3 -0.2 -0.3
Pain all over the body in last month 1.3 1.4 2.2 -0.3 -1.1 -1.0 -1.4 0.0 1.2 -1.5 -1.4 -1.4 -1.5 -1.4
Diabetes (self-reported) 0.6 1.0 1.6 -0.7 -1.2 -1.2 -1.2 -0.2 0.8 -1.0 -1.0 -1.1 -0.9 -1.2
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 5.2 -2.3 -1.3 -1.2 -1.4 -1.7 1.3 -1.4 -1.2 -1.4 -1.4 -0.9
Medication: Ramipril 0.0 0.0 0.2 -0.1 -0.1 -0.1 -0.1 -0.3 0.5 -0.2 -0.1 -0.1 -0.2 0.0
Medication: Simvastatin 0.9 1.2 3.4 0.4 0.8 0.5 1.2 1.9 -0.6 1.2 1.1 1.1 1.2 1.4
Fluid intelligence score 0.1 0.1 0.5 0.6 -0.0 -0.3 -0.0 0.4 -0.2 0.1 0.1 -0.1 -0.0 -0.7
Illnesses of siblings 0.6 0.8 1.1 -1.1 -1.0 -0.9 -1.0 -0.8 0.9 -1.0 -0.9 -0.9 -0.9 -0.6
Neuroticism score 0.2 0.5 2.4 0.1 0.5 0.5 0.6 -1.6 -0.6 0.6 0.7 0.6 0.5 0.2
Weight 7.6 38.2 43.3 -5.9 -6.5 -5.8 -6.3 -5.2 6.6 -6.4 -6.2 -6.3 -6.5 -6.1
Impedance of arm (right) 1.5 7.1 10.4 3.2 2.8 2.3 2.6 3.1 -2.3 2.5 2.2 2.6 2.5 2.8
Arm fat percentage (right) 7.8 31.7 35.8 -5.0 -6.0 -5.2 -5.9 -4.7 6.0 -5.9 -5.7 -5.8 -5.9 -5.7
Trunk fat-free mass 2.8 16.7 19.5 -3.8 -4.4 -4.1 -4.1 -3.2 4.4 -4.1 -4.1 -4.1 -4.2 -4.1
Hip circumference 8.0 35.5 38.8 -6.1 -6.2 -5.4 -6.0 -5.9 6.2 -6.1 -5.9 -6.0 -6.0 -5.6
Time employed in main current job 2.8 3.2 5.5 1.6 1.7 2.3 1.8 0.2 -1.8 1.7 1.9 1.7 1.7 2.3
Alcohol intake versus 10 years previously 4.8 7.3 8.6 -2.2 -2.6 -2.8 -2.8 -2.1 2.6 -2.8 -2.9 -2.8 -2.8 -2.9
Father’s age at death 0.2 0.3 1.8 0.6 -0.3 0.2 -0.2 -1.3 0.1 -0.3 -0.9 -0.3 -0.3 0.2
Worrier / anxious feelings 6.2 11.8 15.8 3.0 3.5 3.2 3.8 1.2 -3.5 3.9 4.0 3.8 3.8 3.4
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 5.6 -1.7 -1.7 -1.6 -1.5 -2.4 1.8 -1.5 -1.3 -1.6 -1.6 -1.9
Falls in the last year 0.1 0.2 0.6 0.6 0.3 0.5 0.2 -0.3 -0.8 0.3 0.3 0.3 0.3 -0.0
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 -0.3 -0.1 -0.5 -0.2 -0.5 0.5 -0.3 -0.2 -0.1 -0.2 0.4
Number of live births 16.7 23.8 28.5 -3.5 -5.3 -4.6 -5.1 -4.4 4.9 -5.1 -5.1 -5.2 -5.1 -5.0
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 6.7 0.5 1.9 1.8 2.0 0.8 -1.7 2.0 1.9 1.9 2.1 2.6
Pulse rate 1.7 2.9 5.6 -1.7 -1.6 -1.8 -1.5 -2.4 1.5 -1.6 -1.6 -1.4 -1.6 -1.8
Happiness 0.2 0.3 0.7 0.5 0.5 0.2 0.5 0.5 -0.6 0.5 0.8 0.5 0.5 0.3
Noisy workplace 0.6 0.8 4.0 -1.4 -0.7 -0.3 -0.7 -2.0 0.1 -0.7 -0.5 -0.5 -0.6 -0.3
Qualifications: A levels/AS levels or equivalent 4.5 10.1 12.0 3.3 3.1 2.6 3.2 3.5 -3.0 3.1 3.3 3.1 3.2 3.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.9 0.9 -0.1 0.5 -0.3 0.3 -0.2 -0.3 -0.2 -0.1 -0.2 -0.9
Mouth/teeth dental problems: Dentures 0.1 0.2 1.1 -0.0 0.2 0.2 0.4 1.0 -0.4 0.5 0.5 0.4 0.4 -0.2
Asthma 0.1 0.2 0.7 -0.8 -0.1 -0.4 -0.4 -0.6 0.5 -0.4 -0.1 -0.3 -0.4 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.6 1.6 0.4 0.7 0.4 0.2 -0.9 0.5 0.7 0.5 0.6 0.5
Medication: Cholesterol lowering 1.9 2.9 3.6 1.5 1.6 1.7 1.8 1.8 -1.9 1.8 1.9 1.8 1.8 1.3
Depression (self-reported) 0.4 0.5 1.1 1.0 0.4 0.8 0.7 -0.6 -0.6 0.7 0.8 0.6 0.6 0.9
Medication: Lansoprazole 0.5 0.6 2.0 0.4 0.9 1.4 0.7 0.4 -1.0 0.5 0.6 0.7 0.7 0.7
Prospective memory result 1.5 1.9 2.6 -0.6 -1.3 -1.2 -1.5 -1.6 1.6 -1.4 -1.2 -1.4 -1.4 -1.5
Lung cancer (father) 3.4 4.0 6.2 -1.5 -1.9 -1.5 -2.1 -2.5 1.7 -2.2 -2.1 -2.1 -2.1 -2.0
Illnesses of mother 0.6 0.7 1.2 -0.8 -0.7 -0.9 -0.7 -0.1 1.1 -0.8 -0.7 -0.8 -0.9 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 6.3 1.3 2.2 1.9 2.2 1.4 -1.9 2.2 2.1 2.1 2.2 2.5
Pulse wave Arterial Stiffness index 1.0 1.2 1.6 -1.0 -0.4 -1.3 -1.2 -0.2 1.2 -1.3 -1.1 -1.2 -1.2 -1.1
Impedance of arm (left) 2.0 9.6 12.5 3.1 3.4 2.9 3.2 3.1 -2.9 3.0 2.8 3.1 3.1 3.5
Arm fat mass (right) 8.6 36.6 41.8 -5.7 -6.5 -5.6 -6.3 -5.0 6.4 -6.3 -6.1 -6.2 -6.4 -6.0
Trunk predicted mass 2.8 16.3 19.2 -3.7 -4.4 -4.0 -4.1 -3.2 4.4 -4.1 -4.0 -4.1 -4.2 -4.1
Standing height 0.1 0.9 1.9 -0.4 -0.9 -1.1 -0.9 0.1 1.4 -1.1 -1.2 -1.0 -1.1 -0.5
Length of working week for main job 3.1 3.4 4.6 1.8 1.8 1.5 2.0 1.6 -1.4 2.0 2.1 1.9 1.9 2.0
Exposure to tobacco smoke at home 1.9 2.1 3.8 -1.9 -1.4 -1.3 -1.4 -1.6 1.3 -1.3 -1.2 -1.3 -1.3 -1.9
Breastfed as a baby 3.0 3.7 6.0 -0.8 -2.4 -1.8 -2.0 -1.8 2.1 -2.0 -2.1 -2.0 -2.1 -1.6
Tense / ‘highly strung’ 2.4 4.0 5.6 1.7 2.1 1.9 2.3 0.4 -2.3 2.3 2.4 2.2 2.3 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.9 -1.1 -0.8 -0.1 -0.5 -1.7 0.2 -0.6 -0.5 -0.5 -0.6 -1.2
Hair/balding pattern: Pattern 4 0.2 0.6 4.8 -0.3 0.4 0.6 0.3 -2.2 -0.6 0.4 0.6 0.3 0.5 0.3
Birth weight of first child 0.5 0.9 2.3 -0.1 -0.9 -1.2 -0.9 -0.8 1.5 -0.9 -1.0 -0.9 -1.0 -0.7
Peak expiratory flow (PEF) 0.1 0.3 1.7 0.0 0.5 0.4 0.6 -0.2 -0.2 0.4 0.4 0.6 0.6 1.3
Pulse wave reflection index 0.1 0.2 0.7 0.3 0.2 -0.4 -0.3 0.8 0.3 -0.3 -0.2 -0.4 -0.2 -0.5
Ever highly irritable/argumentative for 2 days 1.3 1.6 2.4 -0.6 -1.5 -1.2 -1.3 -1.3 1.2 -1.3 -1.0 -1.3 -1.3 -1.6
Loud music exposure frequency 1.2 1.3 2.2 -0.4 -1.4 -1.5 -1.0 -0.8 1.2 -1.0 -1.1 -1.1 -1.0 -1.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 2.8 1.7 1.0 0.7 0.9 0.6 -0.9 0.8 0.8 0.9 0.9 0.6
Mouth/teeth dental problems: Bleeding gums 4.4 5.6 7.8 -0.7 -2.4 -2.5 -2.7 -1.2 2.6 -2.7 -2.8 -2.5 -2.5 -2.4
Blood clot in the leg (DVT) 0.2 0.2 0.7 0.7 -0.1 -0.6 -0.2 0.6 0.8 -0.4 -0.4 -0.3 -0.3 -0.0
Medication: Paracetamol 0.1 0.2 1.7 -0.3 0.1 0.5 0.1 -1.3 -0.5 0.0 0.4 0.1 0.2 0.1
Headache pain in last month 0.2 0.3 3.0 -0.4 -0.3 0.7 -0.1 -1.7 -0.1 -0.1 -0.1 -0.2 -0.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.4 -0.8 -0.9 -0.7 -1.1 -0.8 1.1 -1.1 -1.2 -1.1 -1.1 -0.8
Glaucoma (self-reported) 0.8 0.9 2.2 1.5 0.9 0.6 1.0 0.8 -0.6 0.9 1.0 1.1 1.0 1.0
Gout (self-reported) 0.3 0.5 1.5 0.1 0.5 1.0 0.6 1.2 -0.8 0.5 0.5 0.5 0.6 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 1.0 0.1 0.3 1.0 0.4 -0.5 -0.7 0.4 0.2 0.5 0.4 0.3
Medication: Amlodipine 0.0 0.0 0.3 -0.2 0.0 -0.5 0.1 0.2 -0.1 0.1 0.2 0.2 0.2 -0.2
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.3 -1.4 -0.5 -1.1 -0.7 -0.6 0.6 -0.7 -0.6 -0.7 -0.7 -1.5
Birth weight 0.1 0.3 1.3 0.2 -0.4 -0.3 -0.4 -1.1 0.5 -0.3 -0.4 -0.5 -0.5 -0.1
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 -0.5 -0.5 -0.0 -0.4 -0.4 0.2 -0.6 -0.3 -0.5 -0.4 -0.5
High blood pressure (siblings) 0.3 0.4 2.0 1.4 0.5 0.7 0.5 0.4 -0.7 0.5 0.5 0.4 0.5 0.5
Forced vital capacity (FVC), Best measure 1.8 6.9 9.6 1.4 2.9 2.4 2.8 2.3 -2.6 2.8 2.7 2.7 2.8 3.1
Body fat percentage 7.8 31.6 36.2 -5.2 -6.0 -5.1 -5.9 -4.4 6.0 -5.9 -5.7 -5.8 -6.0 -5.6
Leg fat percentage (right) 9.8 36.1 43.2 -5.4 -6.6 -5.3 -6.3 -4.9 6.2 -6.3 -6.1 -6.2 -6.4 -6.2
Arm fat-free mass (right) 3.6 18.6 22.1 -4.3 -4.7 -4.1 -4.4 -3.8 4.5 -4.4 -4.2 -4.4 -4.5 -4.1
Exposure to tobacco smoke outside home 5.3 7.1 8.3 -2.9 -2.6 -2.2 -2.7 -2.8 2.7 -2.7 -2.6 -2.7 -2.7 -2.7
Comparative body size at age 10 0.3 0.7 2.4 1.6 0.9 0.2 0.7 0.8 -1.0 0.9 0.8 0.7 0.8 -0.2
Number of full brothers 2.4 3.1 4.7 -0.6 -2.1 -1.6 -2.1 -0.8 1.7 -2.0 -1.9 -2.2 -2.0 -1.6
Worry too long after embarrassment 2.2 3.7 5.2 1.2 2.1 1.9 2.3 -0.1 -1.7 2.2 2.3 2.1 2.1 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.2 0.5 0.3 0.6 0.2 -0.6 0.7 0.9 0.7 0.6 -0.0
Wheeze or whistling in the chest in last year 4.4 7.8 11.1 -2.5 -2.7 -2.7 -2.7 -3.3 2.8 -2.7 -2.5 -2.6 -2.8 -3.3
Number of children fathered 0.8 0.9 2.2 -1.4 -0.7 -0.3 -1.0 -1.5 0.6 -0.8 -0.8 -0.8 -0.9 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 7.1 8.2 11.4 3.3 2.7 3.4 2.8 1.8 -3.1 2.8 2.9 2.9 2.9 2.7
Age at first live birth 11.4 20.5 23.8 3.7 4.8 4.3 4.8 3.5 -4.7 4.9 4.6 4.7 4.8 4.9
Pulse wave peak to peak time 0.8 0.9 1.3 0.9 0.3 1.1 1.1 0.2 -1.1 1.1 1.0 1.1 1.0 1.0
Health satisfaction 0.6 0.8 2.5 -1.6 -0.8 -0.7 -0.8 -0.5 0.7 -0.9 -0.8 -0.7 -0.7 -1.3
Shortness of breath walking on level ground 0.9 1.1 5.4 -2.3 -0.9 -0.6 -0.6 -1.5 0.3 -0.7 -0.6 -0.7 -0.6 -1.2
Qualifications: College or University degree 2.4 7.8 10.4 3.0 2.4 2.8 2.7 2.3 -3.0 2.8 2.8 2.7 2.9 3.2
Eye problems/disorders: None of the above 3.2 3.8 6.0 -2.5 -1.8 -1.2 -2.0 -1.8 1.8 -2.0 -2.2 -2.1 -2.1 -1.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.8 -0.9 -0.7 -0.7 -0.8 -0.7 0.9 -0.8 -0.7 -0.8 -0.8 -0.6
Emphysema/chronic bronchitis 0.3 0.4 2.3 -1.5 -0.1 -0.1 0.0 -1.2 0.3 -0.1 0.0 -0.1 -0.2 -0.4
Medication for pain relief, constipation, heartburn 0.2 0.4 1.0 -1.0 -0.6 -0.6 -0.5 0.8 0.8 -0.5 -0.8 -0.5 -0.7 -0.3
Neck or shoulder pain in last month 0.4 0.5 1.1 -0.0 -0.6 -1.1 -0.7 -0.9 0.8 -0.7 -0.4 -0.7 -0.7 -0.8
Medication: Blood pressure 0.6 1.0 1.5 0.1 1.0 0.7 1.1 0.9 -1.0 1.1 1.2 1.1 1.2 1.0
Angina (self-reported) 0.3 0.4 1.1 0.2 0.8 1.1 0.7 -0.5 -0.7 0.5 0.8 0.7 0.6 0.4
Migraine (self-reported) 0.0 0.0 0.2 0.1 0.1 0.1 -0.0 0.2 0.2 0.0 -0.3 -0.0 -0.2 0.4
Medication: Ibuprofen 0.9 1.1 3.2 1.8 0.8 1.1 0.8 0.7 -1.3 0.8 1.0 0.9 1.0 0.8
Medication: Allopurinol 0.1 0.2 0.4 -0.4 -0.4 0.0 -0.4 0.2 0.3 -0.5 -0.5 -0.5 -0.4 -0.6
Medication: Omeprazole 0.1 0.1 0.2 -0.2 0.5 0.2 0.3 -0.4 -0.3 0.2 0.4 0.2 0.3 0.3
Medication: Seretide 50 evohaler 0.1 0.1 0.6 -0.6 0.1 -0.7 -0.1 -0.1 0.3 0.0 0.2 -0.0 -0.1 -0.6
Mean time to correctly identify matches 0.0 0.1 0.6 -0.8 0.0 0.3 0.0 0.2 -0.1 -0.1 -0.1 -0.0 -0.1 -0.1
Heart disease (mother) 1.5 1.8 4.6 2.1 1.2 1.6 1.1 0.8 -1.5 1.1 1.2 1.2 1.2 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.0 1.0 1.2 1.1 1.1 0.7 -1.4 1.2 1.0 1.1 1.2 0.9
Whole body fat mass 9.3 39.7 45.6 -5.8 -6.8 -5.8 -6.6 -5.1 6.6 -6.6 -6.4 -6.5 -6.6 -6.3
Leg fat mass (right) 10.6 42.0 49.2 -6.1 -7.0 -6.0 -6.7 -5.4 6.7 -6.7 -6.5 -6.7 -6.8 -6.5
Arm predicted mass (right) 3.6 18.6 22.0 -4.2 -4.7 -4.1 -4.4 -3.7 4.6 -4.4 -4.3 -4.4 -4.5 -4.1
Pulse rate, automated reading 1.4 4.5 6.1 -2.2 -2.5 -2.3 -2.1 -1.8 2.0 -2.1 -2.0 -2.0 -2.2 -2.1
Alcohol intake frequency. 1.6 3.8 6.1 -2.1 -1.9 -1.8 -1.8 -1.6 1.9 -1.9 -1.9 -2.0 -2.1 -2.5
Comparative height size at age 10 0.6 3.3 6.9 -2.2 -1.4 -2.6 -1.7 -1.0 2.2 -1.7 -1.7 -1.5 -1.8 -1.7
Number of full sisters 1.6 1.9 2.7 -1.4 -1.7 -1.3 -1.4 -1.0 1.2 -1.4 -1.5 -1.4 -1.3 -1.6
Suffer from ‘nerves’ 1.6 2.5 3.7 1.1 1.7 1.3 1.7 -1.1 -1.9 1.7 1.9 1.8 1.9 1.1
Overall health rating 2.1 4.6 5.5 -1.9 -2.3 -2.2 -2.2 -1.9 2.2 -2.2 -2.0 -2.2 -2.1 -2.2
Chest pain or discomfort 0.6 0.9 4.9 -1.3 -0.6 -0.8 -0.7 -2.2 0.6 -0.6 -0.3 -0.5 -0.6 -0.8
Had major operations 0.0 0.1 0.2 0.4 0.1 -0.1 0.2 0.3 -0.1 0.2 0.1 0.3 0.3 0.1
Age at last live birth 3.2 4.7 5.7 1.6 2.2 1.5 2.1 2.3 -2.4 2.4 2.2 2.3 2.3 2.3
Family relationship satisfaction 0.4 0.5 1.5 1.2 0.4 0.4 0.6 1.1 -0.6 0.5 0.6 0.5 0.6 0.3
Leg pain on walking 0.8 1.1 1.5 -1.0 -1.2 -0.3 -1.1 -1.0 0.9 -1.2 -1.0 -1.1 -1.1 -1.2
Qualifications: NVQ or HND or HNC or equivalent 9.8 11.9 14.4 -3.7 -3.7 -3.8 -3.6 -2.1 3.6 -3.6 -3.2 -3.5 -3.5 -3.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.5 0.0 0.4 0.0 0.4 -0.4 0.1 0.1 0.0 0.1 -0.0
Illness, injury, bereavement, stress in last 2 years 4.9 6.0 9.8 1.9 2.2 2.4 2.7 1.7 -2.3 2.6 2.5 2.5 2.6 3.1
Medication: Aspirin 0.2 0.3 0.5 -0.2 -0.7 -0.4 -0.6 -0.3 0.3 -0.6 -0.6 -0.7 -0.6 -0.5
Supplements: Vitamin C 0.1 0.1 0.4 0.3 -0.4 0.3 -0.2 -0.6 0.1 -0.3 -0.3 -0.3 -0.3 -0.3
Knee pain experienced in last month 0.3 0.4 0.8 0.9 0.5 0.2 0.7 0.2 -0.3 0.8 0.8 0.8 0.7 0.7
Hypertension (Self-reported) 0.0 0.1 0.7 0.4 0.1 -0.0 0.1 0.8 0.3 0.1 0.3 0.2 0.2 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.5 0.1 -0.1 0.3 0.3 0.6 0.0 0.2 0.1 0.0 0.3
Illnesses of father: Heart disease 0.2 0.2 0.5 0.6 0.5 -0.3 0.5 -0.3 -0.4 0.5 0.7 0.6 0.5 0.1
Illnesses of siblings: Diabetes 0.2 0.3 1.6 1.0 -0.1 -0.5 -0.0 1.3 0.0 0.2 0.2 0.0 0.0 -0.5
Smoking status: Previous 5.6 8.5 9.5 -2.2 -3.0 -2.8 -3.0 -2.8 3.1 -3.1 -2.9 -3.1 -2.9 -3.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.6 -0.0 -0.8 -0.5 -0.6 0.4 0.6 -0.7 -0.6 -0.6 -0.6 -0.1
Whole body fat-free mass 3.4 19.7 23.2 -4.2 -4.8 -4.3 -4.5 -3.7 4.8 -4.5 -4.4 -4.5 -4.6 -4.3
Leg fat-free mass (right) 3.6 19.6 23.8 -4.2 -4.7 -4.4 -4.5 -3.8 4.9 -4.5 -4.4 -4.5 -4.6 -4.2
Arm fat percentage (left) 7.2 29.4 33.3 -5.2 -5.8 -4.9 -5.6 -4.6 5.8 -5.6 -5.5 -5.5 -5.7 -5.4
Average weekly red wine intake 3.8 5.6 7.3 2.6 2.4 2.2 2.5 1.8 -2.3 2.5 2.3 2.4 2.5 2.7
Handedness (chirality/laterality): Left-handed 3.3 4.0 5.4 -1.2 -1.8 -2.2 -2.2 -1.0 2.1 -2.1 -2.0 -2.1 -2.2 -2.3
Mood swings 0.1 0.2 1.3 -0.6 0.3 -0.1 0.2 -1.2 0.1 0.1 0.3 0.2 0.1 -0.4
Loneliness, isolation 2.8 3.9 5.4 -1.3 -2.2 -2.3 -2.0 -1.7 2.1 -2.0 -2.0 -2.0 -2.1 -1.7
Long-standing illness, disability or infirmity 3.0 4.6 6.5 2.5 2.3 1.7 2.1 1.5 -2.5 2.2 2.4 2.2 2.3 1.3
Ever had bowel cancer screening 6.4 7.4 10.8 3.3 2.8 2.2 2.9 1.6 -2.6 2.9 2.7 2.9 3.0 2.6
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.5 -0.4 -0.5 -0.6 -0.1 0.3 -0.5 -0.4 -0.5 -0.4 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.7 4.0 -1.3 -1.5 -1.8 -1.6 -2.0 1.7 -1.6 -1.6 -1.7 -1.7 -1.4
Friendships satisfaction 0.7 0.9 2.4 1.6 0.6 0.7 0.8 1.4 -0.8 0.8 1.0 0.8 0.9 0.7
Qualifications: nursing, teaching 1.6 2.5 4.7 1.9 1.1 1.6 1.7 0.8 -1.3 1.6 1.7 1.5 1.5 2.2
Commuting to job workplace: Walk 0.1 0.1 0.9 -0.3 -0.2 0.2 0.1 1.0 -0.1 0.1 0.1 0.2 0.2 0.6
Eye problems/disorders: Cataract 0.1 0.1 0.6 0.5 -0.2 -0.8 -0.3 -0.1 0.2 -0.2 -0.0 -0.1 -0.2 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.8 -1.0 -0.7 -0.4 -1.2 -2.0 0.7 -1.2 -1.0 -1.1 -1.0 -0.7
Medication for cholesterol 0.0 0.1 0.4 -0.2 -0.2 0.0 -0.1 -0.4 -0.1 -0.0 -0.1 -0.1 -0.2 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.6 0.3 -0.1 0.4 0.1 -0.1 0.5 0.3 0.5 0.5 0.1
Back pain experienced in last month 0.5 0.7 2.1 -1.3 -0.6 -0.6 -0.6 -1.4 0.4 -0.6 -0.5 -0.6 -0.7 -1.2
Mineral and other dietary supplements 1.0 1.3 2.6 0.7 0.9 1.2 0.9 1.6 -1.2 0.9 1.2 0.9 1.1 1.4
Breast cancer (self-reported) 3.1 3.7 6.6 -2.4 -1.6 -1.8 -1.7 -2.6 2.2 -1.7 -1.7 -1.7 -1.8 -1.7
Asthma (self-reported) 0.1 0.2 0.5 -0.7 0.2 -0.2 -0.2 -0.6 0.3 -0.2 0.1 -0.1 -0.2 -0.6
Osteoporosis (self-reported) 3.9 4.8 6.3 1.9 2.5 1.5 2.4 2.1 -2.1 2.5 2.0 2.3 2.3 2.5
Osteoarthritis (self-reported) 0.2 0.3 0.8 0.9 0.8 -0.0 0.6 0.1 -0.5 0.6 0.6 0.7 0.5 -0.0
Medication: Aspirin 0.0 0.0 0.1 0.4 -0.0 0.2 0.0 0.1 -0.3 0.0 0.1 -0.0 0.1 0.2
Medication: Gliclazide 1.3 1.5 2.1 -0.4 -1.3 -1.1 -1.4 -0.0 1.1 -1.4 -1.4 -1.4 -1.4 -1.4
Illnesses of father: None of the above (group 1) 0.2 0.2 0.8 0.6 0.2 0.9 0.3 0.4 -0.1 0.2 0.2 0.2 0.1 0.7
Smoking status: Current 1.5 2.3 4.6 -1.2 -1.5 -2.1 -1.6 -0.3 1.4 -1.5 -1.3 -1.5 -1.6 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.0 0.3 1.9 1.6 1.6 0.5 -1.7 1.6 2.0 1.7 1.9 2.2
Whole body water mass 3.4 19.6 23.0 -4.2 -4.7 -4.3 -4.5 -3.7 4.8 -4.5 -4.4 -4.5 -4.6 -4.3
Leg predicted mass (right) 3.6 19.5 23.7 -4.2 -4.6 -4.4 -4.4 -3.8 4.9 -4.5 -4.4 -4.5 -4.6 -4.2
Arm fat mass (left) 8.6 36.4 41.9 -5.8 -6.4 -5.6 -6.2 -5.0 6.5 -6.2 -6.0 -6.2 -6.3 -6.0
Number of self-reported non-cancer illnesses 0.8 1.4 2.0 1.2 1.2 0.5 1.3 1.1 -0.7 1.3 1.3 1.3 1.2 1.4
Average weekly champagne plus white wine intake 0.7 1.0 1.4 1.0 1.0 1.1 1.2 0.4 -0.8 1.0 1.1 1.0 1.0 0.8
Miserableness 0.2 0.4 2.0 -0.2 -0.2 -1.0 -0.3 -1.4 0.6 -0.3 -0.3 -0.3 -0.5 -0.7
Guilty feelings 0.3 0.5 3.7 -0.8 -0.6 -0.1 -0.3 -1.9 -0.1 -0.2 -0.2 -0.2 -0.2 -0.6
Wears glasses or contact lenses 0.1 0.2 0.8 0.0 -0.2 0.1 -0.3 -0.9 0.1 -0.4 -0.5 -0.4 -0.4 -0.2
Ever taken oral contraceptive pill 0.9 1.0 3.5 -0.9 -0.9 -1.1 -0.9 -1.9 0.8 -0.8 -0.8 -0.9 -0.9 -0.9
Hearing aid user 0.1 0.1 0.7 0.3 0.2 -0.5 0.2 0.8 -0.1 0.3 0.4 0.2 0.4 0.2
Mother’s age at death 0.4 0.5 0.9 0.9 0.9 0.6 0.6 0.0 -0.9 0.7 0.8 0.7 0.7 0.8
Financial situation satisfaction 0.4 0.5 2.1 -1.4 -0.4 -0.7 -0.5 -0.4 -0.0 -0.4 -0.5 -0.5 -0.4 -1.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.3 0.0 1.1 1.1 1.1 -0.0 -0.7 0.9 0.9 1.1 1.0 1.1
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.2 0.1 -0.5 0.1 0.2 0.6 0.0 -0.1 0.1 -0.2 0.0
Eye problems/disorders: Glaucoma 0.8 0.9 2.0 1.4 0.8 0.6 0.8 1.2 -0.7 0.8 1.0 1.0 1.0 0.9
Medication: Blood pressure 0.0 0.1 0.3 -0.0 -0.3 -0.2 -0.2 -0.2 0.5 -0.3 -0.1 -0.2 -0.2 0.4
Pain type(s) experienced in last month: Hip pain 1.7 2.1 5.0 -1.8 -1.1 -1.4 -1.3 -2.2 1.4 -1.3 -1.2 -1.3 -1.3 -1.3
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.0 -0.9 -0.8 -1.0 -1.0 -1.1 1.2 -1.1 -1.4 -1.0 -1.3 -1.4
High cholesterol (Self-reported) 0.0 0.1 0.6 0.0 -0.2 0.1 0.1 0.7 0.0 0.1 0.2 0.1 0.2 0.4
Medication: Bendroflumethiazide 1.2 1.8 3.2 -1.8 -1.7 -1.3 -1.4 -0.5 1.3 -1.4 -1.3 -1.3 -1.3 -1.2
Medication: Paracetamol 0.2 0.2 0.6 -0.3 0.5 0.8 0.4 -0.3 -0.6 0.4 0.7 0.4 0.5 0.5
Medication: Lisinopril 0.1 0.1 0.3 -0.2 0.1 0.5 -0.0 0.4 0.1 -0.1 -0.3 -0.1 -0.1 0.4
Medication: Atorvastatin 0.1 0.1 0.3 -0.5 -0.3 0.4 -0.2 -0.5 -0.2 -0.3 -0.3 -0.2 -0.2 -0.2
Illnesses of father: High blood pressure 0.1 0.2 0.4 0.3 0.5 -0.1 0.4 0.1 -0.7 0.4 0.5 0.4 0.4 -0.4
Alcohol drinker status: Never 0.5 0.6 1.1 0.7 0.6 0.3 0.9 0.6 -0.5 0.9 1.1 0.9 0.8 0.9
Ever smoked 7.0 12.5 15.8 -2.7 -3.7 -3.9 -3.6 -3.2 3.6 -3.5 -3.4 -3.6 -3.6 -4.0
Basal metabolic rate 4.4 24.9 29.3 -4.8 -5.3 -4.8 -5.1 -4.2 5.4 -5.1 -5.0 -5.1 -5.2 -4.8
Leg fat percentage (left) 9.7 35.9 42.9 -5.4 -6.5 -5.3 -6.3 -4.9 6.2 -6.2 -6.0 -6.2 -6.3 -6.2
Arm fat-free mass (left) 4.7 24.5 28.6 -4.5 -5.3 -4.8 -5.0 -4.3 5.3 -5.0 -4.9 -5.1 -5.2 -4.8
Number of operations (self-reported) 2.1 3.2 4.2 1.6 1.9 1.5 2.0 1.4 -1.7 1.9 2.0 1.9 2.0 1.7
Average weekly beer plus cider intake 0.5 0.7 1.0 -0.9 -1.0 -1.0 -0.8 -0.2 1.0 -0.9 -0.8 -0.8 -0.8 0.4
Irritability 0.6 1.1 2.0 -0.5 -1.1 -1.1 -0.9 -1.0 1.0 -1.0 -0.9 -0.9 -1.1 -1.4
Risk taking 2.0 3.0 4.2 -0.9 -1.7 -1.3 -1.9 -0.9 1.9 -2.0 -2.0 -2.0 -2.0 -1.7
Ever had prostate specific antigen (PSA) test 7.3 8.3 10.8 3.3 3.1 2.7 3.2 1.8 -2.5 3.0 3.1 3.1 2.9 2.8
Fractured/broken bones in last 5 years 0.9 1.1 2.0 0.6 1.4 0.5 1.1 1.1 -1.0 1.2 1.3 1.2 1.1 0.9
Age started oral contraceptive pill 0.2 0.2 0.4 0.2 0.3 0.1 0.4 0.7 -0.6 0.5 0.3 0.4 0.5 0.7
Diastolic blood pressure, automated reading 0.3 0.8 1.6 -1.3 -0.9 -1.2 -0.8 -1.0 1.0 -0.8 -0.8 -0.7 -0.8 -0.6
Ever depressed for a whole week 0.0 0.0 0.1 0.1 0.2 -0.0 0.0 -0.0 -0.4 0.1 0.1 0.2 0.1 -0.3
Unable to work because of sickness or disability 0.1 0.1 0.4 -0.1 -0.5 -0.4 -0.3 -0.3 0.1 -0.2 -0.2 -0.2 -0.2 -0.6
Commuting to job workplace: Cycle 2.3 2.8 5.7 1.5 1.7 2.4 1.7 0.8 -1.7 1.5 1.5 1.6 1.8 1.7
Myopia 0.3 0.5 1.7 1.3 0.4 0.6 0.4 0.9 -0.7 0.5 0.6 0.4 0.5 0.9
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.7 -0.6 -0.2 0.1 -0.2 -0.9 -0.0 -0.2 -0.3 -0.3 -0.3 -0.1
Cholesterol lowering medication 0.1 0.2 0.5 -0.5 -0.2 -0.7 -0.2 0.7 0.7 -0.2 -0.3 -0.4 -0.1 0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.3 0.7 0.2 0.5 -0.3 -0.2 0.4 0.6 0.4 0.5 0.5
Pain experienced in last month 1.1 1.9 5.8 0.9 1.3 1.0 1.4 2.4 -1.2 1.4 0.9 1.3 1.3 1.3
Supplements: Calcium 0.2 0.2 1.3 -0.7 -0.0 -0.5 -0.0 -1.1 -0.3 0.1 -0.1 0.0 -0.1 -0.3
Basal cell carcinoma (self-reported) 0.6 0.7 1.5 1.2 0.4 1.2 0.7 1.0 -0.7 0.5 0.6 0.6 0.7 1.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 2.4 0.9 1.2 0.4 1.4 0.9 -1.3 1.4 1.4 1.5 1.6 1.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.5 0.2 -0.5 -1.0 -0.7 0.0 1.2 -0.9 -0.8 -0.8 -0.8 -0.4
Heart disease (siblings) 0.2 0.2 1.2 1.1 0.1 -0.1 0.2 0.9 -0.1 0.1 0.3 0.1 0.1 -0.3
Alcohol drinker status: Previous 0.0 0.0 0.2 -0.1 0.1 -0.0 0.1 0.5 -0.3 0.1 0.1 0.0 0.1 -0.2
Pack years of smoking 0.2 0.3 0.8 -0.3 -0.5 -0.5 -0.5 -0.8 0.3 -0.5 -0.5 -0.4 -0.6 -0.9
Impedance of whole body 2.5 12.9 16.1 3.7 3.7 3.4 3.6 3.8 -3.4 3.4 3.3 3.5 3.5 4.0
Leg fat mass (left) 10.6 42.6 50.0 -6.1 -7.1 -6.0 -6.8 -5.4 6.8 -6.8 -6.6 -6.7 -6.9 -6.6
Arm predicted mass (left) 4.3 22.5 26.0 -4.3 -5.1 -4.6 -4.9 -3.9 5.1 -4.8 -4.7 -4.9 -5.0 -4.7