Hub : Genes

LA16c-349E10.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.138	0.0450	6.8e-04	0.095	NA	0.100	NA	0.092	3.2e-08	NA	1.4e-08	NA	5.9e-08
2	GTEx	Artery Aorta	0.204	0.0680	1.8e-04	0.134	NA	0.114	NA	0.127	8.2e-08	NA	8.2e-07	NA	1.8e-07
3	GTEx	Artery Tibial	0.105	0.0316	2.3e-05	0.108	NA	0.081	NA	0.104	8.1e-09	NA	6.6e-07	NA	1.7e-08
4	GTEx	Brain Cerebellar Hemisphere	0.343	0.1090	4.3e-04	0.132	NA	0.192	NA	0.208	3.0e-04	NA	1.1e-05	NA	4.7e-06
5	GTEx	Brain Cerebellum	0.178	0.0830	8.5e-03	0.212	NA	0.185	NA	0.187	6.8e-07	NA	3.8e-06	NA	3.4e-06
6	GTEx	Colon Sigmoid	0.182	0.0620	1.0e-03	0.186	NA	0.111	NA	0.176	3.8e-07	NA	9.6e-05	NA	8.3e-07
7	GTEx	Esophagus Mucosa	0.308	0.0780	4.9e-04	-0.003	NA	-0.004	NA	0.002	6.2e-01	NA	7.1e-01	NA	2.1e-01
8	GTEx	Esophagus Muscularis	0.242	0.0630	6.1e-05	0.067	NA	0.068	NA	0.095	6.4e-05	NA	6.3e-05	NA	2.2e-06
9	GTEx	Lung	0.118	0.0446	1.5e-03	0.011	NA	0.066	NA	0.060	4.3e-02	NA	9.2e-06	NA	2.4e-05
10	GTEx	Nerve Tibial	0.199	0.0544	6.9e-06	0.106	NA	0.169	NA	0.182	6.0e-08	NA	5.2e-12	NA	6.5e-13
11	GTEx	Skin Not Sun Exposed Suprapubic	0.223	0.0640	6.7e-04	0.071	NA	0.030	NA	0.055	9.9e-05	NA	9.1e-03	NA	5.5e-04
12	GTEx	Skin Sun Exposed Lower leg	0.122	0.0460	7.6e-03	0.124	NA	0.109	NA	0.121	2.0e-10	NA	2.7e-09	NA	3.1e-10
13	GTEx	Testis	0.310	0.0830	5.6e-04	0.124	NA	0.136	NA	0.130	3.8e-06	NA	1.3e-06	NA	2.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.0	0.1	0.3	0.1	0.4	0.1	0.1	-0.4	0.2	0.0	0.0	0.5	-0.0	-0.3	0.0	0.0
Bipolar Disorder or Schizophrenia	0.6	1.5	5.1	-1.7	1.1	0.8	-1.0	-2.3	0.8	-1.6	-0.5	-0.7	-0.9	-2.0	0.0	0.0
Depressed Affect (Nagel 2018)	0.7	1.4	3.6	-1.0	-1.7	-1.9	1.5	1.7	-1.5	0.5	-1.2	-1.1	-0.7	-0.3	-0.1	-0.4
Depression (Nagel 2018)	0.9	1.3	3.4	1.6	-0.4	-0.2	1.1	1.4	-0.2	1.8	0.5	0.5	1.3	1.6	1.7	0.7
Intelligence (Savage-Jansen 2018)	1.2	3.8	11.6	2.2	2.2	2.5	-1.4	-0.8	2.4	0.7	3.4	1.7	1.7	1.8	1.8	-1.2
Neuroticism (Nagel 2018)	0.3	0.6	2.2	1.0	-0.3	-0.2	0.3	0.7	0.4	1.5	0.5	0.4	1.4	0.9	1.0	0.0
Schizophrenia (2018)	1.1	2.3	6.7	-2.0	1.1	0.9	-1.4	-2.6	0.9	-2.3	-0.6	-1.3	-1.2	-2.4	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	1.0	2.2	5.7	1.2	1.6	1.8	-1.7	-0.9	2.4	1.2	1.8	1.4	2.1	0.9	0.7	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	-0.5	-0.8	-1.0	0.9	0.2	-0.9	-0.6	-1.0	-1.4	-0.8	-0.6	-0.3	-1.3
Alzheimer’s Disease (in father)	1.8	1.9	5.0	0.9	-1.7	-1.3	1.8	2.2	-1.5	1.8	-0.6	0.7	0.4	1.4	1.5	0.8
Alzheimer’s Disease (including proxy)	1.9	2.8	7.0	-0.0	-2.5	-2.4	2.6	2.1	-2.3	0.2	-2.1	-1.3	-1.1	-0.0	0.4	-0.7
Crohns Disease (2017)	0.1	0.1	0.7	0.6	-0.0	0.2	-0.1	-0.1	0.1	0.8	0.1	0.7	0.3	0.3	0.1	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	1.1	0.3	0.2	0.3	-0.1	-0.1	0.4	0.7	0.3	0.5	0.2	0.3	-0.1	1.0
Ulcerative Colitis (UC)	0.1	0.2	1.1	0.2	0.0	-0.0	0.2	0.4	0.2	0.6	0.3	0.4	0.1	0.4	0.2	1.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	2.0	3.7	13.2	0.9	2.4	2.5	-3.6	-2.3	2.3	-0.1	2.0	1.9	0.8	0.2	-0.3	1.9
Verbal and Numeric Reasoning (VNR)	1.5	3.7	9.5	1.8	2.4	2.6	-1.6	-1.1	2.5	0.7	3.1	1.9	1.9	1.7	1.6	-0.5
Breast Cancer	0.3	0.8	2.1	0.5	-0.5	-0.5	1.1	1.2	-0.9	1.1	0.3	-1.3	0.5	0.9	1.4	-0.0
Ovarian Cancer	0.4	0.6	2.5	-1.6	0.1	0.0	0.1	-0.6	-0.2	-0.9	-0.6	-0.7	-0.9	-0.9	-0.9	-0.7
Prostate Cancer	1.4	2.0	3.6	0.9	1.7	1.7	-1.9	-1.1	1.9	1.2	1.7	1.3	1.6	0.7	0.2	1.1
Age at First Birth	2.9	4.2	9.7	0.7	3.1	3.1	-2.3	-2.3	2.9	0.5	2.9	2.2	1.1	0.7	0.3	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.6	2.2	4.9	-2.2	-0.9	-1.3	0.6	-0.2	-1.2	-1.5	-1.9	-1.6	-1.8	-2.0	-1.9	-0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.7	1.1	2.1	1.0	1.3	1.5	-1.5	-1.0	1.4	0.0	0.0	1.4	1.1	0.7	0.0	0.0
Mean Putamen Volume	1.2	1.3	3.4	-0.5	-1.6	-1.8	1.8	1.4	-1.8	0.3	-1.1	-0.4	-0.8	-0.1	0.2	-0.4
Fasting Glucose	0.6	0.7	1.6	0.1	-0.5	-0.7	1.0	0.2	-1.1	-0.5	-1.1	-1.3	-1.1	-0.6	-0.7	0.9
HbA1C	1.4	1.6	4.1	-0.4	-2.0	-1.7	1.8	1.7	-1.7	0.4	-1.7	-1.0	-0.8	-0.0	0.2	0.1
HDL Cholesterol	0.9	1.4	4.6	1.1	1.1	1.2	-0.8	-0.5	1.0	0.7	1.5	2.1	0.9	1.0	0.6	1.8
LDL Cholesterol	0.9	1.4	4.0	0.1	-1.8	-1.7	2.0	1.9	-1.5	0.3	-1.0	-0.5	-0.0	0.3	0.7	0.6
Lupus	0.4	0.6	3.4	1.0	0.6	0.6	-1.1	-0.3	0.3	0.2	0.6	-0.6	0.2	0.3	0.3	1.9
Neuroticism (2016)	0.6	0.8	1.7	1.2	0.7	0.7	-0.5	-0.0	1.1	1.0	1.1	0.0	1.2	0.9	0.8	1.3
Primary Biliary Cirrhosis	0.3	0.4	1.0	1.0	-0.5	-0.5	0.6	1.0	-0.4	0.4	-0.3	0.4	0.4	0.6	0.9	0.6
Rheumatoid Arthritis	0.4	0.6	1.9	-1.4	0.1	0.0	0.2	-0.8	-0.4	-1.2	-0.2	-0.0	-1.1	-1.0	-1.2	0.0
Schizophrenia (2014)	1.1	2.4	7.2	-2.2	0.6	0.4	-0.9	-2.2	0.4	-2.7	-1.1	-0.8	-1.9	-2.7	0.0	0.0
Triglycerides	0.2	0.3	0.9	0.6	-0.6	-0.6	0.5	1.0	-0.1	0.3	-0.6	-0.0	0.4	0.3	0.6	-0.9
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.3	-0.4	-0.1	-0.2	-0.1	0.6	0.3	0.5	0.0	0.4	0.5	0.4	0.0	0.0
Blood Eosinophil Count	0.6	5.0	13.7	1.1	2.6	2.8	-2.8	-2.2	2.9	0.2	2.3	3.7	1.6	0.9	0.2	2.3
Blood Platelet Count	1.9	22.0	49.8	-1.0	-7.0	-7.1	6.8	6.4	-7.0	0.7	-4.9	-4.0	-2.5	-0.2	1.3	0.5
Blood Red Count	0.2	2.1	6.9	0.1	1.4	1.8	-1.8	-1.4	2.0	-0.3	0.6	0.7	2.2	0.3	-0.2	2.6
Blood White Count	0.2	1.7	3.7	-0.3	-1.6	-1.9	0.8	1.2	-1.9	-0.5	-1.9	-1.7	-0.7	-0.6	-0.1	1.7
Heel T-Score	0.3	2.6	8.5	2.1	-1.5	-1.5	1.9	2.3	-1.3	0.4	-0.8	0.2	0.2	1.3	1.8	-2.9
BMI	0.8	4.8	8.6	-2.8	-2.1	-2.7	1.8	0.7	-2.8	-1.5	-2.9	-2.1	-2.6	-2.3	-1.9	0.5
Height	4.8	92.5	204.5	3.1	13.5	14.3	-12.8	-11.3	14.2	1.1	10.7	11.4	7.4	3.2	0.7	1.2
Waist Hip Ratio (WHR)	0.1	0.6	1.5	-1.0	-0.1	-0.3	-0.4	-0.6	-0.4	-1.0	-1.0	-0.7	-0.8	-1.2	-1.1	0.8
Systolic Blood Pressure	0.3	1.5	4.2	-0.3	2.0	1.9	-1.4	-2.1	1.6	-0.7	0.8	0.4	0.7	-0.4	-1.0	0.5
Smoking Status	7.1	17.0	41.2	-2.2	-6.2	-6.4	5.6	4.7	-6.0	-0.3	-5.1	-3.1	-2.7	-1.3	-0.5	-1.4
Allergy or Eczema	0.6	1.5	3.9	-1.8	-1.4	-1.7	1.3	0.8	-2.0	-0.3	-1.2	-0.6	-1.6	-0.9	-0.6	0.3
Cardiovascular Disease	0.6	2.0	7.3	0.4	1.8	1.5	-1.7	-1.5	1.8	0.2	0.8	1.5	1.1	0.1	-0.4	2.7
Hypothyroidism (self reported)	0.2	0.5	1.0	0.3	-0.7	-0.6	0.8	1.0	-0.7	0.6	0.7	0.7	-0.1	0.8	0.5	0.9
Respiratory disease	2.6	5.9	15.1	1.6	-2.3	-1.9	2.8	3.9	-2.3	3.2	-0.2	1.8	1.0	2.7	3.1	2.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.6	1.5	-0.1	-0.0	0.8	1.2	-0.0	2.1	0.3	0.6	1.8	1.6	1.6	2.1
Lung FEV1/FVC ratio	0.3	1.5	3.4	-0.8	0.8	0.3	-0.9	-1.6	0.4	-1.8	-1.0	-1.7	-0.9	-1.8	-1.8	-0.6
Lung FVC	1.2	6.2	19.8	0.4	-3.9	-3.5	4.5	3.7	-3.5	1.1	-1.8	-0.9	-1.0	0.6	1.0	0.1
Neuroticism	0.4	0.9	3.6	0.9	-0.0	0.1	0.2	0.9	0.6	1.9	0.6	-0.7	1.6	0.9	1.0	1.1
Chronotype (morning person)	0.1	0.3	0.9	0.2	0.6	0.4	-0.5	-0.7	0.9	-0.3	-0.1	-0.9	0.4	-0.4	-0.4	0.9
Hair Pigment	0.1	3.4	10.2	-1.4	2.4	1.9	-2.3	-3.2	1.6	-1.7	0.5	-0.8	-0.8	-1.9	-2.4	1.3
Tanning	0.0	0.4	1.6	-1.3	0.6	0.4	-0.1	-0.7	0.7	-0.6	-0.2	0.6	0.1	-0.4	-0.5	-0.7
Hand grip strength (left)	0.3	0.8	6.4	-0.6	0.5	0.3	-0.3	-1.0	0.1	-0.8	0.1	0.7	-0.9	-0.6	-0.6	-2.5
Number of treatments/medications taken	0.5	0.9	8.1	0.7	-0.5	-0.5	0.1	0.7	-0.4	0.7	-0.2	0.7	0.3	0.4	0.4	2.9
Average weekly spirits intake	2.5	3.1	6.5	1.0	2.3	2.4	-1.7	-1.1	2.4	1.2	2.6	1.2	2.2	1.3	1.0	1.0
Sensitivity / hurt feelings	1.2	2.1	5.3	1.2	1.9	2.0	-1.9	-1.4	2.3	0.4	1.6	1.0	1.7	0.6	0.4	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.6	1.3	0.1	0.2	0.0	0.5	-0.1	0.8	0.5	-0.5	0.8	0.8	1.1	0.3
Hearing difficulty/problems: Yes	1.5	2.3	6.6	1.6	0.2	0.5	-0.0	1.2	0.7	1.8	1.4	0.9	2.3	2.2	2.6	1.6
Relative age of first facial hair	0.4	0.8	2.9	0.1	0.7	0.9	-0.5	-0.1	1.0	0.8	1.3	1.7	1.0	0.9	0.8	-0.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	4.1	1.0	-1.1	-0.7	0.9	2.0	-0.6	2.0	0.3	1.3	1.2	1.9	2.0	1.4
Ever used hormone-replacement therapy (HRT)	2.6	3.3	7.2	2.3	-0.2	0.1	1.3	2.0	-0.0	2.6	1.2	1.4	2.4	2.6	2.7	1.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	-0.8	1.0	0.8	-0.9	-1.3	1.0	-0.6	0.3	-1.1	0.1	-1.0	-1.1	0.7
Systolic blood pressure, automated reading	0.2	0.4	2.2	-0.0	0.8	0.7	-0.7	-0.8	0.5	-0.3	0.1	0.7	0.6	-0.0	-0.3	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	0.8	0.8	0.7	-1.0	-0.2	0.9	0.4	1.0	0.4	0.9	0.6	0.4	1.4
Angina	0.8	1.0	2.7	-1.4	0.7	0.5	-1.0	-1.6	0.4	-0.8	-0.4	-0.7	-0.8	-1.4	-1.6	0.4
Medication for hormone replacement therapy	0.5	0.5	1.9	0.1	0.3	0.4	0.1	0.5	0.5	0.9	0.4	1.4	1.3	1.0	0.7	0.6
Vitamin and mineral supplements	1.8	2.4	5.1	-1.1	-1.9	-2.0	1.1	0.6	-1.9	-1.2	-2.2	-0.8	-1.5	-1.6	-1.2	-1.9
Supplements: Zinc	0.2	0.2	0.5	-0.5	-0.3	-0.6	0.5	0.5	-0.6	0.3	-0.0	-0.3	-0.7	-0.0	-0.1	0.6
Medication: Co-codamol	1.8	2.0	4.3	-1.5	-2.0	-2.1	1.7	1.3	-1.8	-0.4	-1.8	-1.4	-0.7	-0.8	-0.9	1.0
Medication: Metformin	1.9	2.6	7.9	1.4	0.8	1.0	0.1	1.0	1.2	2.4	1.3	1.3	2.8	2.2	2.1	1.3
Diabetes (father)	1.3	1.6	4.8	0.8	-1.9	-1.7	1.7	2.2	-1.8	0.8	-0.8	0.0	-0.2	0.6	0.9	0.8
Diabetes (mother)	0.3	0.4	2.2	0.4	-0.2	-0.1	-0.1	0.3	-0.2	-0.4	0.1	1.5	0.2	0.3	0.4	1.5
Severe depression (siblings)	1.5	1.6	3.8	-0.1	-1.9	-1.9	1.1	1.4	-1.9	-0.5	-1.6	-1.4	-1.3	-0.5	-0.1	-0.5
Pack years adult smoking proportion	0.9	1.3	3.7	-1.9	-1.1	-1.4	1.5	0.6	-1.3	-0.2	-1.7	-0.3	-0.9	-0.9	-0.9	-0.7
Impedance of leg (right)	0.5	2.2	6.1	0.6	-2.2	-1.9	2.1	2.5	-1.4	0.8	-1.1	-0.4	0.3	0.8	1.1	-1.8
Leg fat-free mass (left)	2.0	10.5	27.6	-1.6	4.8	4.5	-4.9	-5.2	4.2	-1.0	2.6	2.8	0.6	-1.0	-1.8	0.7
Trunk fat percentage	0.2	0.7	1.6	-1.2	-0.8	-1.1	0.8	0.9	-0.8	0.9	-0.9	0.6	0.3	0.1	0.2	1.1
Hand grip strength (right)	0.5	1.5	11.1	-1.1	-0.1	-0.1	0.1	-0.8	-0.4	-1.3	-0.4	0.2	-1.4	-1.1	-1.0	-3.3
Townsend deprivation index at recruitment	2.6	3.7	8.9	0.2	-2.8	-2.7	2.8	2.2	-3.0	-0.9	-2.2	-1.4	-1.7	-0.6	0.0	-0.3
Current tobacco smoking	3.7	6.0	14.7	-1.4	-3.8	-3.8	3.0	2.8	-3.7	-0.3	-3.2	-1.2	-1.7	-0.9	-0.4	0.7
Average weekly fortified wine intake	0.1	0.1	0.4	0.0	0.1	0.1	-0.1	0.1	0.3	0.1	0.4	-0.7	0.4	0.2	0.4	0.1
Maternal smoking around birth	1.4	2.0	4.6	-0.5	-1.5	-1.6	1.7	0.7	-2.1	-0.6	-1.6	-1.9	-2.1	-1.1	-0.7	-0.9
Fed-up feelings	2.5	4.6	7.9	-2.4	-2.2	-2.6	1.5	1.0	-2.5	-1.5	-2.5	-2.8	-2.5	-2.1	-1.7	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.1	1.2	-1.2	-1.1	1.3	1.4	-1.0	0.8	-0.3	-0.3	0.1	0.7	1.0	1.1
Relative age voice broke	0.2	0.4	1.4	-0.4	0.6	0.5	-0.5	-0.7	0.9	-0.5	0.4	1.2	0.2	-0.2	-0.3	-0.6
Taking other prescription medications	0.7	1.1	5.6	0.1	-1.0	-1.1	0.8	1.2	-0.9	1.4	-0.7	0.9	0.3	0.6	0.4	2.4
Age when periods started (menarche)	0.6	1.3	2.8	-0.7	-1.5	-1.6	0.9	0.9	-1.5	0.1	-1.3	-1.7	-1.3	-0.7	-0.5	-1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	-0.1	1.0	0.7	-0.9	-0.7	1.2	0.3	0.5	0.4	0.7	-0.0	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	0.1	-1.1	-1.3	1.0	0.8	-1.2	-0.9	-1.1	-1.1	-1.0	-0.4	-0.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.5	0.6	0.7	-0.4	-0.2	0.7	0.7	0.9	0.0	0.8	0.6	0.6	1.1
Qualifications: CSEs or equivalent	0.9	1.2	2.9	-0.6	-0.9	-1.2	0.9	0.6	-1.3	-0.7	-1.4	-1.7	-1.4	-1.0	-0.9	1.1
Serious illness, injury or assault to yourself	1.4	1.7	6.7	0.8	-1.0	-0.8	1.7	1.6	-0.8	1.4	-0.1	1.2	0.8	1.2	1.3	2.6
High blood pressure	2.1	5.9	12.9	1.5	3.3	3.2	-3.2	-2.5	3.3	0.3	2.2	1.9	2.1	0.6	0.0	3.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	-1.4	-0.6	-0.9	0.8	0.3	-1.2	-0.3	-0.8	-0.1	-1.3	-0.8	-0.8	0.8
Multivitamins +/- minerals	1.2	1.5	3.2	0.1	1.8	1.8	-1.4	-0.8	1.7	0.8	1.5	0.7	1.2	0.9	0.5	1.4
Stomach or abdominal pain in last month	1.2	1.5	3.9	-0.5	-1.7	-1.7	1.5	1.4	-2.0	0.3	-1.2	-0.5	-0.8	-0.2	0.1	1.8
Supplements: Glucosamine	0.9	1.2	3.8	-0.2	-1.6	-1.5	1.8	1.9	-1.5	0.4	-0.6	0.3	-0.5	0.5	0.7	0.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.2	1.0	-0.0	0.4	1.4	1.5	0.2	1.6	1.2	1.4	1.6	2.2	2.3	-0.5
Medication: Atenolol	0.4	0.5	1.4	-0.2	0.8	0.7	-1.1	-1.2	0.5	-0.7	-0.3	0.3	0.0	-0.7	-0.9	0.9
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.3	-0.8	-0.7	0.6	0.8	-0.8	0.4	0.0	0.4	-0.0	0.5	0.3	0.5
Sitting height	4.1	29.2	64.2	1.7	7.4	8.0	-7.2	-6.0	7.8	1.1	6.3	6.6	4.3	2.1	0.8	0.5
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	-0.8	-1.2	-1.4	1.0	0.7	-1.3	-0.3	-1.4	-0.6	-1.0	-0.8	-0.7	-0.2
High blood pressure (mother)	0.7	1.0	1.8	1.0	1.3	1.3	-0.7	-0.3	1.3	0.6	1.2	-0.2	1.2	1.0	0.9	1.1
Body mass index (BMI)	0.7	3.1	6.1	-2.2	-1.9	-2.3	1.5	0.9	-2.5	-0.9	-2.5	-1.7	-1.8	-1.5	-1.1	1.1
Impedance of leg (left)	0.5	2.6	6.8	0.5	-2.5	-2.2	2.3	2.6	-1.7	0.8	-1.5	-0.5	0.0	0.6	0.8	-1.8
Leg predicted mass (left)	2.0	10.3	27.2	-1.6	4.8	4.5	-4.9	-5.2	4.2	-1.1	2.5	2.8	0.6	-1.0	-1.8	0.7
Trunk fat mass	0.2	0.7	2.2	-1.3	0.9	0.6	-0.9	-0.9	0.7	0.4	0.1	1.5	0.5	-0.1	-0.3	1.0
Waist circumference	0.2	0.8	4.4	-1.3	0.6	0.3	-0.8	-1.0	0.1	-0.2	-0.4	0.9	-0.2	-0.7	-0.7	2.1
Number of incorrect matches in round	3.3	5.4	12.3	1.5	3.0	3.0	-3.1	-2.1	3.5	0.9	2.6	2.8	2.1	1.1	0.6	1.8
Past tobacco smoking	5.8	10.6	19.8	2.6	4.0	4.4	-3.3	-2.1	4.2	1.6	3.8	4.1	3.4	2.4	1.8	2.8
Alcohol usually taken with meals	1.7	2.7	7.7	-0.4	2.1	2.0	-2.6	-2.8	1.9	-1.2	0.8	0.7	-0.3	-1.1	-1.5	-1.2
Nervous feelings	0.5	1.0	2.3	1.2	1.0	1.1	-1.4	-0.7	1.5	0.6	0.8	1.0	1.3	0.5	0.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.0	0.8	0.6	0.6	-0.5	0.3	0.9	1.4	1.2	0.6	1.5	1.2	1.2	1.7
Hearing difficulty/problems with background noise	1.9	3.0	8.4	2.5	-0.6	-0.3	0.7	2.0	-0.1	2.6	1.0	0.6	2.1	2.4	2.9	1.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.5	0.4	1.6	1.5	-0.9	-1.1	1.5	-0.3	1.2	0.5	0.7	0.3	0.1	1.0
Had menopause	1.1	1.4	2.6	1.3	0.9	1.3	-1.0	-0.2	1.1	0.9	1.6	1.3	1.4	1.3	1.3	1.3
Had other major operations	1.8	2.3	6.1	1.9	-0.9	-0.7	0.8	1.8	-0.5	1.8	0.7	1.1	1.2	1.9	2.1	2.5
Forced vital capacity (FVC)	0.8	3.0	7.1	0.5	2.4	2.5	-1.8	-2.0	2.7	0.8	2.1	2.4	1.1	0.6	-0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.2	-0.6	-1.8	-2.0	1.7	1.3	-2.0	-1.0	-1.7	-1.2	-1.6	-0.6	-0.3	-1.2
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	9.1	1.4	-0.9	-0.7	1.0	1.8	-0.3	2.1	0.3	1.4	1.4	1.5	1.4	3.0
Qualifications: None of the above	4.4	9.5	20.9	-1.8	-4.2	-4.5	3.8	3.1	-4.6	-0.4	-4.2	-3.0	-2.3	-1.6	-1.1	0.5
Financial difficulties in last 2 years	0.5	0.7	2.4	-0.3	-1.1	-1.1	0.9	0.8	-1.1	-0.0	-0.9	-0.3	-0.6	-0.3	-0.0	1.5
Mouth/teeth dental problems	0.4	0.6	2.2	-1.3	0.9	0.6	0.1	-0.7	0.3	-0.4	0.2	-1.0	-0.4	-0.6	-0.9	-1.5
Heart attack	0.2	0.3	0.9	0.6	-0.4	-0.4	0.6	0.7	-0.5	0.8	0.1	-0.4	0.0	0.3	0.5	0.9
Allergy	0.8	1.9	4.4	0.5	1.7	1.8	-1.8	-2.0	2.1	-1.2	1.0	-0.6	0.7	-0.3	-0.4	-1.8
Pain all over the body in last month	0.7	0.7	2.3	0.6	-1.1	-0.9	1.1	1.5	-0.8	0.6	-0.9	-0.5	0.5	0.7	0.9	0.2
Diabetes (self-reported)	3.5	5.4	10.6	2.8	1.5	1.8	-0.2	0.6	1.6	3.0	2.1	2.7	3.2	2.9	2.6	2.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	3.0	-1.7	-0.5	-0.5	0.7	0.3	-0.6	0.1	-0.4	0.0	-0.3	-0.2	-0.4	-0.6
Medication: Ramipril	0.6	0.8	1.9	0.6	1.1	1.2	-0.8	-0.6	1.4	0.9	1.3	0.4	1.1	0.6	0.5	0.0
Medication: Simvastatin	0.6	0.9	4.5	1.2	0.2	0.3	-0.2	0.5	0.3	1.3	0.4	0.5	1.1	1.0	0.9	2.1
Fluid intelligence score	2.4	4.9	13.4	2.1	2.8	3.1	-1.8	-1.5	3.1	0.8	3.7	1.6	2.1	1.8	1.6	0.1
Illnesses of siblings	1.0	1.4	3.1	0.3	-1.7	-1.7	1.1	1.4	-1.7	0.7	-1.2	0.0	-0.9	-0.1	0.3	-1.8
Neuroticism score	0.1	0.2	0.6	0.5	-0.1	-0.1	-0.3	0.2	0.4	0.7	-0.1	-0.5	0.8	0.0	0.1	0.3
Weight	0.7	3.5	8.4	-1.3	2.7	2.5	-2.8	-2.9	2.3	-0.3	1.3	2.0	0.6	-0.4	-0.8	1.4
Impedance of arm (right)	0.7	3.4	8.4	1.7	0.0	0.6	0.5	1.8	1.0	2.6	1.8	2.3	2.4	2.9	2.5	-0.2
Arm fat percentage (right)	0.8	3.2	7.1	-1.6	-2.4	-2.7	2.4	2.1	-2.7	0.1	-2.1	-1.1	-1.1	-0.4	0.1	1.2
Trunk fat-free mass	2.4	13.9	35.5	-0.9	5.5	5.4	-5.7	-6.0	4.9	-1.4	3.1	3.5	0.7	-1.0	-1.9	0.7
Hip circumference	0.5	2.1	4.8	-0.7	1.9	1.9	-2.0	-1.8	1.7	0.4	1.2	2.2	0.9	0.3	0.0	1.4
Time employed in main current job	0.8	0.9	3.4	-0.6	1.3	1.0	-1.1	-1.3	0.9	-0.4	0.6	0.9	0.2	-0.3	-0.5	1.9
Alcohol intake versus 10 years previously	2.4	3.5	9.6	-1.0	-2.6	-2.8	3.1	2.0	-2.8	0.1	-1.9	-1.4	-1.7	-0.6	-0.3	0.1
Father’s age at death	2.6	3.5	6.8	1.7	1.6	2.1	-1.1	-0.1	1.8	2.4	2.2	2.3	2.6	2.3	1.8	0.4
Worrier / anxious feelings	0.9	1.7	5.2	2.3	1.1	1.5	-1.4	-0.8	1.8	0.9	1.5	1.0	1.5	0.8	0.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	9.0	0.9	-2.6	-2.6	2.7	3.0	-2.3	1.3	-1.5	-0.9	0.1	0.8	1.3	1.4
Falls in the last year	0.9	1.3	3.1	-1.6	-1.3	-1.5	0.6	0.3	-1.1	0.2	-1.8	-0.3	-1.2	-1.2	-1.2	0.8
Hair/balding pattern: Pattern 3	1.9	2.8	6.6	-1.8	-0.1	-0.4	-1.0	-1.5	-0.1	-2.4	-1.3	-0.8	-2.0	-2.4	-2.6	-2.3
Number of live births	0.3	0.4	1.5	-0.8	-0.4	-0.4	0.4	0.1	-0.6	-0.3	-0.1	-1.2	-0.8	-0.7	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.3	0.4	2.1	2.2	-1.5	-2.0	2.3	0.3	1.5	1.6	0.7	0.1	-0.4	-0.4
Pulse rate	1.8	3.1	8.9	0.4	-1.8	-1.6	3.0	2.9	-1.8	1.7	-0.2	-0.1	0.9	1.6	2.0	1.9
Happiness	4.3	5.3	11.2	2.7	2.5	2.9	-2.0	-1.3	2.6	0.9	3.0	3.3	2.2	1.9	1.5	1.5
Noisy workplace	0.4	0.6	1.3	-0.8	-0.9	-1.1	0.4	0.6	-0.8	-0.6	-1.1	-0.4	-0.7	-0.5	-0.4	0.9
Qualifications: A levels/AS levels or equivalent	3.3	7.3	18.1	1.8	3.1	3.7	-2.0	-1.3	3.4	1.9	4.3	2.8	3.0	2.6	2.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.1	1.5	0.5	0.8	-0.3	-0.1	0.8	0.6	0.7	0.7	0.9	0.9	0.8	0.8
Mouth/teeth dental problems: Dentures	0.7	1.2	3.0	-1.7	-0.0	-0.4	-1.4	-1.2	-0.0	-1.3	-1.4	-0.2	-0.9	-1.6	-1.6	0.2
Asthma	1.1	2.1	6.7	0.6	-1.8	-1.6	1.7	2.6	-1.7	1.8	-0.5	0.6	0.1	1.3	1.5	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.7	0.3	1.2	1.1	-0.3	-1.1	0.7	-0.2	1.2	0.5	-0.3	-0.1	-0.1	1.3
Medication: Cholesterol lowering	0.1	0.1	0.5	0.6	0.5	0.2	-0.2	-0.2	0.4	0.5	-0.2	0.0	0.5	0.3	0.1	0.7
Depression (self-reported)	0.2	0.3	0.7	-0.0	0.7	0.6	-0.8	-0.6	0.7	-0.4	0.0	0.8	0.6	0.1	0.1	0.2
Medication: Lansoprazole	1.0	1.2	7.4	1.0	0.5	0.6	-0.2	0.1	0.5	1.4	0.8	1.0	1.1	0.9	0.6	2.7
Prospective memory result	1.0	1.3	6.2	0.4	0.7	0.5	-0.9	-1.6	0.4	-0.9	-0.5	-2.5	-0.5	-1.5	-1.6	-0.1
Lung cancer (father)	0.4	0.5	2.1	-1.5	0.4	0.2	-0.4	-0.6	0.5	0.0	-0.1	-0.9	0.0	-0.7	-0.8	-1.0
Illnesses of mother	0.3	0.3	0.7	-0.8	-0.7	-0.6	0.5	0.1	-0.4	0.2	-0.4	-0.2	-0.5	-0.6	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.4	0.6	2.0	2.1	-1.3	-1.8	2.1	0.3	1.6	1.1	0.7	0.2	-0.3	0.1
Pulse wave Arterial Stiffness index	3.0	3.5	12.0	0.4	2.1	2.0	-1.5	-0.9	2.0	1.7	2.0	3.5	2.1	1.5	0.9	1.7
Impedance of arm (left)	1.0	4.4	9.5	2.0	0.7	1.3	-0.1	1.3	1.8	3.0	2.4	2.5	3.0	3.1	2.6	0.1
Arm fat mass (right)	0.2	0.7	3.2	-1.8	-0.4	-0.7	0.3	-0.0	-0.8	-0.3	-1.0	-0.1	-0.8	-0.8	-0.6	1.2
Trunk predicted mass	2.5	14.4	36.2	-0.8	5.6	5.5	-5.8	-6.0	5.0	-1.4	3.2	3.6	0.8	-0.9	-1.8	0.7
Standing height	5.0	49.3	110.2	1.2	10.0	10.5	-9.7	-8.8	10.3	0.8	7.9	8.0	4.8	1.8	-0.2	0.5
Length of working week for main job	0.6	0.6	1.6	0.2	-1.2	-1.1	0.9	1.3	-1.2	0.7	-0.7	0.5	-0.2	0.3	0.3	0.4
Exposure to tobacco smoke at home	1.5	1.7	4.0	-0.1	-1.7	-2.0	1.8	1.5	-1.7	0.6	-1.4	-1.7	-0.7	-0.3	-0.1	1.2
Breastfed as a baby	2.0	2.5	6.1	1.1	2.2	2.5	-2.4	-1.8	1.9	-0.0	2.2	0.6	1.0	0.5	0.4	0.8
Tense / ‘highly strung’	1.8	2.9	7.5	0.2	2.5	2.4	-2.6	-2.3	2.7	-0.2	1.5	1.1	1.3	-0.0	-0.5	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.8	1.5	-0.4	-0.1	1.1	1.5	-0.0	1.6	0.8	1.2	1.7	1.9	2.0	0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.6	1.0	0.7	0.7	-0.4	-0.1	0.6	1.1	1.0	1.6	1.1	0.8	0.5	0.9
Birth weight of first child	0.2	0.3	0.8	-0.5	0.6	0.7	-0.6	-0.5	0.5	0.8	0.9	0.4	0.1	0.2	-0.0	-0.4
Peak expiratory flow (PEF)	0.8	1.8	4.1	-0.3	1.9	2.0	-1.7	-1.8	2.0	0.4	1.4	1.6	0.9	0.2	-0.1	-0.7
Pulse wave reflection index	0.8	1.0	4.1	0.3	1.1	1.1	-1.3	-0.8	1.1	0.8	1.1	2.0	0.8	0.5	0.1	0.4
Ever highly irritable/argumentative for 2 days	1.8	2.2	6.0	0.7	-2.0	-1.9	2.2	2.2	-1.8	0.7	-1.1	-0.2	0.1	0.3	0.6	2.4
Loud music exposure frequency	4.7	5.1	12.0	0.4	-3.4	-3.2	3.3	3.1	-3.5	0.7	-2.1	-1.9	-1.2	0.1	0.9	-1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.0	-0.8	1.1	1.1	-1.0	-1.7	0.9	-1.3	0.5	0.1	-0.9	-0.7	-1.0	-1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	5.1	2.3	0.4	0.9	-0.3	0.3	0.8	0.9	1.2	1.4	1.3	1.4	1.5	1.1
Blood clot in the leg (DVT)	0.8	1.0	3.2	-0.3	-1.4	-1.5	0.9	1.2	-1.8	-0.2	-1.1	-0.4	-1.4	-0.7	-0.4	0.2
Medication: Paracetamol	0.5	0.9	8.7	0.6	-0.1	-0.2	0.2	0.1	-0.4	0.7	-0.1	-1.1	-0.0	-0.0	0.1	3.0
Headache pain in last month	1.4	2.3	10.1	1.9	-1.4	-1.4	1.4	1.9	-1.2	1.6	-0.7	0.1	0.4	1.0	1.2	3.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.0	-0.6	-0.4	0.4	0.8	-0.5	0.2	0.1	0.3	-0.1	0.3	0.5	-0.5
Glaucoma (self-reported)	0.2	0.2	0.7	-0.6	0.7	0.5	-0.8	-0.5	0.8	0.3	0.4	0.3	0.3	-0.0	-0.3	0.3
Gout (self-reported)	3.1	4.2	7.6	2.0	2.7	2.7	-1.6	-1.1	2.6	1.2	2.8	1.5	2.3	1.9	1.8	1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	-0.4	-0.9	-1.0	0.6	0.7	-0.9	0.1	-0.0	0.6	-0.6	0.1	-0.1	-0.0
Medication: Amlodipine	1.3	1.9	4.8	0.4	2.2	1.9	-1.9	-1.6	1.9	0.8	1.0	1.3	1.1	0.3	-0.1	1.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.7	0.0	-1.3	-1.2	1.5	1.6	-1.5	1.2	-0.5	0.5	-0.5	0.5	0.7	-0.1
Birth weight	0.2	0.4	1.2	-0.5	-0.4	-0.5	0.6	-0.2	-0.5	-0.3	-0.6	-1.1	-0.8	-0.8	-0.7	-1.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.4	-1.1	-0.9	-0.9	0.9	0.2	-1.2	-0.8	-1.4	-1.2	-1.5	-1.0	-0.8	-1.6
High blood pressure (siblings)	1.1	1.6	3.8	-0.5	1.7	1.8	-1.4	-2.0	1.7	-1.1	1.0	-0.1	0.7	-0.4	-0.8	1.4
Forced vital capacity (FVC), Best measure	0.7	2.6	6.2	0.6	2.3	2.4	-1.8	-2.0	2.5	0.5	2.1	1.8	0.9	0.4	-0.2	0.1
Body fat percentage	0.5	2.0	5.0	-1.6	-1.9	-2.2	1.6	1.6	-2.0	0.4	-2.0	-0.5	-0.6	-0.4	-0.1	0.9
Leg fat percentage (right)	1.7	6.0	13.9	-1.8	-3.4	-3.7	2.7	2.4	-3.7	-0.5	-3.6	-2.1	-1.8	-1.3	-0.5	0.6
Arm fat-free mass (right)	1.8	9.4	26.9	-1.3	4.5	4.2	-4.7	-5.2	3.9	-1.4	2.1	2.5	0.3	-1.3	-2.0	0.3
Exposure to tobacco smoke outside home	1.2	1.6	4.2	0.4	-1.6	-1.5	1.9	1.6	-1.6	1.3	-1.1	0.1	0.2	0.2	0.2	2.0
Comparative body size at age 10	1.8	5.0	11.6	-0.8	-3.2	-3.3	3.3	2.7	-3.4	-0.0	-2.5	-1.9	-1.8	-0.6	-0.1	-0.0
Number of full brothers	0.9	1.2	5.5	0.0	-1.3	-1.1	1.1	1.6	-0.5	1.4	-0.5	-0.1	0.8	0.5	0.4	2.4
Worry too long after embarrassment	0.2	0.3	0.7	0.8	-0.1	0.2	-0.8	0.0	0.6	0.8	0.1	-0.8	0.8	0.3	0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.7	1.3	-0.4	-0.5	1.2	1.7	-0.3	1.7	0.5	-0.0	1.9	1.9	2.2	1.3
Wheeze or whistling in the chest in last year	2.1	3.7	8.7	0.3	-2.8	-3.0	2.7	2.9	-2.7	0.8	-2.4	-1.1	-0.8	0.0	0.6	-0.2
Number of children fathered	0.8	0.9	2.0	-0.1	-1.3	-1.3	1.4	1.0	-1.4	-0.4	-1.4	-0.7	-0.7	-0.2	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.5	-1.4	-0.5	-1.0	0.6	0.2	-0.7	-0.6	-1.0	-1.6	-0.8	-0.7	-0.6	-0.5
Age at first live birth	3.6	6.4	15.4	1.1	3.8	3.8	-3.4	-3.1	3.9	-0.0	2.8	2.2	1.5	0.5	-0.0	-0.9
Pulse wave peak to peak time	1.9	2.2	8.8	-0.4	-1.4	-1.4	0.9	0.3	-1.3	-1.7	-1.5	-3.0	-1.7	-1.4	-0.9	-1.7
Health satisfaction	3.3	4.3	12.3	2.6	0.9	1.2	-0.3	0.8	1.2	2.1	1.7	3.0	2.2	2.4	2.3	3.5
Shortness of breath walking on level ground	2.0	2.4	6.7	1.2	-2.0	-1.9	1.9	2.3	-1.5	1.2	-1.1	-0.8	0.2	0.5	0.7	2.6
Qualifications: College or University degree	4.0	12.6	27.2	2.4	4.8	5.2	-4.3	-2.9	5.1	1.5	5.0	3.0	2.9	2.4	1.8	-0.3
Eye problems/disorders: None of the above	0.3	0.4	0.9	-0.8	0.1	0.0	0.3	-0.5	-0.4	-0.3	-0.2	-0.7	-0.8	-0.8	-0.9	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.9	1.2	-0.2	-0.2	0.4	1.3	-0.4	1.5	0.9	0.5	0.5	1.5	1.7	0.8
Emphysema/chronic bronchitis	0.5	0.5	1.4	-0.3	-1.1	-1.2	0.8	0.8	-1.1	-0.4	-0.9	-0.5	-0.5	-0.3	-0.2	0.5
Medication for pain relief, constipation, heartburn	0.6	1.1	4.6	0.2	0.2	0.7	0.2	0.6	0.4	0.7	0.8	1.9	0.9	1.3	1.2	-2.1
Neck or shoulder pain in last month	1.4	2.1	6.7	0.5	-1.9	-1.9	2.6	2.0	-2.0	1.0	-1.1	-0.8	-0.2	0.3	0.9	1.0
Medication: Blood pressure	1.1	1.9	4.9	-0.1	2.2	1.9	-1.9	-2.0	2.1	-0.0	1.2	0.6	1.0	-0.1	-0.6	1.0
Angina (self-reported)	0.9	1.2	3.2	-1.4	0.8	0.7	-1.2	-1.7	0.7	-0.9	-0.3	-0.7	-0.8	-1.5	-1.8	0.4
Migraine (self-reported)	0.7	0.8	4.6	1.5	0.3	0.5	0.1	0.5	0.4	0.9	0.6	0.0	0.8	0.9	0.8	2.2
Medication: Ibuprofen	0.1	0.2	1.0	0.4	0.3	0.2	0.2	-0.1	0.0	0.3	0.5	0.7	-0.2	0.2	0.3	1.0
Medication: Allopurinol	2.4	3.2	5.9	2.0	2.2	2.4	-1.9	-1.2	2.3	1.0	2.1	1.7	1.9	1.4	1.1	1.3
Medication: Omeprazole	1.0	1.2	2.7	-1.6	-0.9	-1.0	0.5	-0.2	-0.7	-0.9	-1.5	-1.6	-0.8	-1.5	-1.5	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.6	-0.1	-0.2	0.1	0.2	-0.4	0.1	-0.2	0.5	-0.2	0.0	0.1	0.5
Mean time to correctly identify matches	2.5	4.7	10.4	2.2	2.1	2.4	-3.1	-1.2	2.2	1.0	2.3	2.8	1.7	1.4	1.0	3.2
Heart disease (mother)	1.7	2.0	6.6	0.7	2.0	2.0	-2.6	-1.8	1.9	-0.7	1.3	1.0	0.8	0.2	0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.5	0.7	1.8	1.9	-1.5	-1.4	1.7	-0.1	1.4	0.8	0.9	0.2	-0.2	1.1
Whole body fat mass	0.1	0.5	2.8	-1.7	0.1	-0.3	-0.3	-0.4	-0.1	0.1	-0.7	0.8	-0.2	-0.5	-0.6	1.1
Leg fat mass (right)	0.4	1.5	4.7	-2.2	-1.0	-1.4	0.5	0.0	-1.4	-0.8	-2.0	-0.7	-1.2	-1.4	-1.1	0.6
Arm predicted mass (right)	2.0	10.2	29.9	-1.5	4.6	4.3	-5.0	-5.5	4.0	-1.6	2.1	2.5	0.2	-1.5	-2.3	0.1
Pulse rate, automated reading	1.7	5.6	15.4	0.1	-3.3	-3.3	3.9	3.7	-3.4	1.0	-2.0	-1.0	-0.5	0.7	1.4	0.9
Alcohol intake frequency.	2.4	5.5	13.4	-1.1	-3.5	-3.4	3.7	3.0	-3.5	0.5	-2.4	-2.0	-1.3	-0.4	0.3	0.1
Comparative height size at age 10	4.2	23.2	51.0	-0.4	7.0	7.1	-6.9	-6.6	7.1	-0.6	5.0	5.1	2.6	0.4	-1.1	0.2
Number of full sisters	0.6	0.7	1.7	-0.4	-1.3	-1.3	1.0	1.1	-1.1	0.2	-1.1	0.3	-0.5	-0.1	-0.0	0.7
Suffer from ‘nerves’	0.6	0.9	3.3	-0.7	-1.0	-1.0	0.2	0.1	-0.5	-0.3	-1.5	-1.8	-0.4	-1.0	-0.9	-1.2
Overall health rating	0.9	1.9	4.0	-0.9	-1.6	-2.0	1.2	0.9	-1.7	-0.7	-2.0	-0.6	-1.2	-1.1	-0.9	2.0
Chest pain or discomfort	1.6	2.2	5.1	0.0	-2.0	-2.0	2.3	1.7	-2.0	0.2	-1.4	-1.5	-1.0	-0.2	-0.0	2.1
Had major operations	2.5	2.9	6.9	-0.9	-2.6	-2.6	1.9	2.3	-2.6	0.4	-2.5	-0.6	-0.9	-0.3	0.1	-0.4
Age at last live birth	2.0	2.9	6.1	1.6	2.3	2.5	-1.7	-1.5	2.3	1.2	2.2	1.5	1.7	0.9	0.5	0.5
Family relationship satisfaction	0.1	0.1	1.0	1.0	0.2	0.3	0.4	-0.0	0.1	-0.1	0.2	0.1	0.2	0.3	0.3	0.0
Leg pain on walking	0.7	0.9	7.6	0.7	0.5	0.5	-0.7	-0.1	0.8	0.2	0.4	-0.0	1.0	0.5	0.3	2.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.6	0.4	-1.9	-2.0	2.1	1.9	-2.1	0.6	-1.6	-0.7	-0.3	0.4	0.9	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.7	-0.1	-0.1	-0.0	0.2	0.5	-0.2	0.5	0.1	1.3	0.1	0.3	0.2	0.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.4	0.7	1.5	1.6	-1.3	-1.1	1.3	0.4	1.4	0.4	1.1	0.6	0.1	0.5
Medication: Aspirin	0.2	0.3	1.5	0.6	-0.3	-0.4	-0.5	-0.0	0.0	-0.4	-0.4	-0.8	-0.1	-0.4	-0.4	1.2
Supplements: Vitamin C	0.7	0.8	2.1	0.5	1.3	1.4	-0.9	-0.9	1.0	0.3	1.3	0.1	0.3	0.3	0.0	1.4
Knee pain experienced in last month	3.9	6.1	14.2	-0.9	-3.7	-3.8	2.5	2.6	-3.6	-0.7	-3.3	-2.4	-1.9	-1.3	-0.6	1.0
Hypertension (Self-reported)	2.1	5.8	13.5	1.6	3.1	3.0	-3.0	-2.2	3.2	0.8	2.2	2.1	2.3	0.8	0.2	3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.4	-0.6	-1.2	-1.1	1.6	0.7	-1.2	-0.2	-1.2	-0.5	-0.3	-0.2	-0.3	1.2
Illnesses of father: Heart disease	2.1	3.0	6.8	2.6	1.5	1.6	-0.7	-0.4	2.1	0.9	1.7	1.7	2.2	1.5	1.3	2.5
Illnesses of siblings: Diabetes	0.9	1.1	1.9	-1.2	-1.1	-1.2	0.6	0.5	-1.3	-1.1	-1.2	-1.4	-0.9	-0.8	-0.5	1.4
Smoking status: Previous	4.0	6.0	13.0	-1.6	-3.0	-3.3	2.8	1.7	-3.0	-0.9	-2.6	-3.6	-2.4	-1.6	-1.2	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	12.0	0.6	3.1	3.2	-3.5	-2.5	3.4	0.3	2.5	1.8	1.3	0.8	0.2	-0.1
Whole body fat-free mass	2.3	13.3	34.0	-1.2	5.4	5.2	-5.5	-5.8	4.8	-1.3	3.0	3.4	0.7	-1.0	-1.9	0.8
Leg fat-free mass (right)	2.2	11.6	29.4	-1.4	5.1	4.8	-5.2	-5.4	4.5	-1.0	2.9	3.1	0.7	-0.8	-1.8	0.9
Arm fat percentage (left)	0.7	2.6	6.0	-1.7	-2.1	-2.4	2.1	1.9	-2.3	0.2	-2.0	-1.1	-1.0	-0.5	-0.1	1.1
Average weekly red wine intake	0.3	0.4	2.1	-0.7	-0.2	-0.0	-0.5	-0.5	-0.0	-0.8	-0.3	-0.9	-0.4	-0.6	-0.3	-1.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.3	0.4	-0.0	0.0	-0.3	0.6	0.2	0.8	0.3	1.1	0.6	0.8	0.6	0.2
Mood swings	0.1	0.3	1.3	-0.2	-0.4	-0.6	0.5	0.5	-0.2	-0.1	-0.5	-0.8	0.1	-0.2	-0.2	1.1
Loneliness, isolation	0.7	0.9	2.3	-0.2	-1.0	-1.3	0.6	1.2	-1.5	0.1	-1.3	-1.1	-0.6	-0.3	0.1	1.3
Long-standing illness, disability or infirmity	3.2	4.9	14.5	1.6	-2.3	-2.0	2.7	3.8	-1.9	2.7	-0.2	1.0	1.2	2.4	2.7	2.0
Ever had bowel cancer screening	0.4	0.5	1.8	-0.3	-1.0	-1.0	1.3	0.6	-0.9	0.4	-0.8	-0.1	-0.4	-0.2	-0.3	0.4
Diabetes diagnosed by doctor	4.4	7.2	14.3	3.3	1.4	1.7	-0.3	0.9	1.7	3.6	2.4	2.6	3.8	3.3	3.1	3.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.6	-0.7	-0.8	-1.2	1.2	0.2	-0.9	-0.6	-0.8	-1.0	-1.0	-0.9	-0.9	-0.4
Friendships satisfaction	2.1	2.7	4.4	2.1	1.6	2.1	-0.9	-0.5	1.6	0.6	2.0	2.1	1.6	1.7	1.6	1.7
Qualifications: nursing, teaching	0.6	0.9	3.6	-0.2	1.0	1.3	-1.0	-0.8	1.3	0.3	1.1	0.7	0.4	0.5	0.3	-1.9
Commuting to job workplace: Walk	0.4	0.5	2.3	0.0	-0.9	-0.9	0.5	0.6	-0.7	-0.1	-0.7	-0.4	-0.2	-0.0	0.3	-1.5
Eye problems/disorders: Cataract	0.2	0.3	0.9	-0.0	0.6	0.5	-1.0	-0.6	0.8	-0.4	0.1	0.6	0.3	-0.1	-0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.3	0.5	-2.3	-2.0	1.5	1.7	-2.0	0.2	-1.5	-1.2	-1.0	-0.1	0.3	1.0
Medication for cholesterol	0.9	1.3	2.7	-0.3	-1.3	-1.5	1.4	0.7	-1.5	-0.6	-1.1	-1.2	-1.4	-0.7	-0.5	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.2	4.8	-1.5	-1.6	-1.9	1.0	0.3	-1.9	-1.0	-2.2	-0.3	-2.0	-1.6	-1.4	-0.7
Back pain experienced in last month	2.7	4.0	11.5	0.2	-3.4	-3.2	2.3	2.4	-2.8	0.4	-2.6	-1.2	-0.9	-0.4	-0.0	1.2
Mineral and other dietary supplements	0.2	0.3	0.9	-0.1	0.3	0.1	-0.4	-0.8	0.1	-0.8	-0.5	-0.4	-0.3	-0.9	-0.9	-0.3
Breast cancer (self-reported)	1.8	2.2	4.0	1.7	1.5	1.6	-1.5	-0.6	1.8	1.1	2.0	1.8	1.4	1.4	1.2	1.1
Asthma (self-reported)	1.4	2.7	8.5	0.8	-2.0	-1.7	1.9	2.9	-1.9	2.0	-0.5	0.8	0.2	1.6	1.8	1.2
Osteoporosis (self-reported)	1.0	1.2	3.2	1.3	-0.8	-0.5	1.0	1.7	-0.3	1.8	0.1	0.9	0.9	1.3	1.4	0.8
Osteoarthritis (self-reported)	2.6	3.3	8.3	-0.5	-2.6	-2.6	2.9	2.2	-2.8	-0.7	-1.9	-1.0	-1.4	-0.3	0.1	1.2
Medication: Aspirin	0.3	0.3	2.0	1.0	0.2	0.1	-0.7	-0.1	0.5	0.1	0.0	-0.4	0.6	-0.0	-0.0	1.4
Medication: Gliclazide	0.4	0.5	1.5	0.4	0.2	0.2	0.3	0.6	0.0	0.9	0.8	-0.3	1.0	1.0	1.2	0.6
Illnesses of father: None of the above (group 1)	1.7	2.1	7.5	-2.7	-0.0	-0.2	-0.6	-1.0	-0.4	-1.1	-0.5	-2.1	-1.4	-1.5	-1.3	-2.5
Smoking status: Current	3.2	5.1	12.8	-1.5	-3.4	-3.6	2.8	2.5	-3.4	-0.2	-3.1	-0.9	-1.6	-0.9	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.6	1.6	0.4	0.6	0.3	0.6	0.5	1.2	1.3	1.4	1.2	1.4	1.5	1.1
Whole body water mass	2.2	12.3	32.6	-1.3	5.2	5.0	-5.3	-5.7	4.5	-1.4	2.8	3.1	0.5	-1.1	-1.9	0.7
Leg predicted mass (right)	2.1	11.4	29.2	-1.4	5.0	4.7	-5.1	-5.4	4.5	-1.0	2.8	3.0	0.7	-0.9	-1.8	0.8
Arm fat mass (left)	0.2	0.8	3.7	-1.9	-0.4	-0.8	0.3	-0.2	-0.8	-0.4	-1.1	-0.3	-0.9	-1.0	-0.8	0.9
Number of self-reported non-cancer illnesses	1.4	2.4	8.8	1.7	-0.6	-0.5	0.9	1.8	-0.5	2.1	0.2	1.5	1.4	1.8	1.6	3.0
Average weekly champagne plus white wine intake	4.4	6.1	14.2	0.9	3.6	3.8	-3.4	-3.1	3.6	0.2	3.0	2.1	1.7	0.6	-0.2	0.1
Miserableness	1.5	2.5	6.2	0.5	-2.5	-2.5	2.3	2.3	-2.2	0.4	-1.6	-0.9	-0.6	-0.1	0.4	1.1
Guilty feelings	0.7	1.1	2.7	1.6	-0.7	-0.5	0.6	1.5	-0.0	1.7	0.4	0.4	1.2	1.2	1.3	0.8
Wears glasses or contact lenses	2.9	3.4	6.1	1.2	2.3	2.3	-2.4	-1.3	2.4	1.1	2.5	2.0	1.9	1.2	1.1	1.2
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.1	-0.6	-0.5	0.9	0.8	-0.8	-0.7	-0.0	-0.7	-0.7	0.0	0.4	-0.2
Hearing aid user	2.3	2.6	6.1	-0.6	-2.2	-2.3	2.5	2.3	-2.4	0.2	-1.5	-1.2	-1.1	0.2	0.6	-0.1
Mother’s age at death	0.3	0.4	1.9	-0.5	-0.9	-0.8	0.7	0.7	-0.9	0.2	-0.3	-0.2	-0.3	0.1	0.1	-1.4
Financial situation satisfaction	1.2	1.5	4.0	0.3	-1.9	-1.7	2.0	1.5	-2.0	0.1	-1.1	0.2	-1.2	-0.2	0.0	0.4
Tinnitus: Yes, now most or all of the time	3.3	3.9	7.2	-2.1	-1.8	-2.2	1.0	0.3	-2.4	-2.1	-2.7	-2.1	-2.7	-2.1	-1.5	-1.2
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.6	0.1	0.4	0.5	0.3	0.3	0.6	1.0	-0.1	0.6	0.9	1.0	0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	0.2	0.7	0.8	-1.1	-0.4	1.1	0.4	1.0	0.8	0.7	0.5	0.5	0.2
Medication: Blood pressure	2.7	5.1	11.0	1.1	3.3	3.3	-3.1	-2.6	3.1	0.1	2.3	1.8	1.8	0.5	0.1	2.1
Pain type(s) experienced in last month: Hip pain	2.6	3.2	8.0	0.1	-2.8	-2.7	2.7	2.7	-2.6	0.4	-1.8	-0.6	-0.6	0.4	0.8	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	-0.3	-1.0	-1.0	0.6	0.8	-0.9	-0.3	-0.7	-0.3	-0.5	-0.1	0.2	0.5
High cholesterol (Self-reported)	0.6	1.0	2.3	1.5	0.1	0.3	-0.5	0.6	0.4	1.3	0.5	0.7	1.5	1.3	1.2	1.5
Medication: Bendroflumethiazide	1.5	2.3	6.2	-0.2	2.3	1.7	-2.4	-2.5	1.8	-1.4	0.4	-0.2	-0.3	-1.3	-1.5	0.6
Medication: Paracetamol	0.3	0.5	5.7	0.2	-0.1	-0.2	-0.2	-0.0	-0.2	0.7	-0.1	-0.4	-0.1	-0.1	0.1	2.4
Medication: Lisinopril	2.4	3.1	8.3	2.1	1.9	2.0	-2.1	-1.0	2.0	1.0	1.6	1.6	1.7	1.0	0.6	2.9
Medication: Atorvastatin	0.2	0.2	1.6	0.5	-0.1	-0.2	-0.5	-0.1	0.3	0.1	-0.4	1.3	0.2	-0.0	-0.2	0.5
Illnesses of father: High blood pressure	0.6	0.8	3.4	1.5	0.5	0.7	-0.4	-0.1	0.6	0.3	0.7	1.0	0.5	0.8	0.7	1.9
Alcohol drinker status: Never	0.3	0.3	0.8	-0.6	0.6	0.5	-0.7	-0.9	0.2	-0.7	0.0	0.6	-0.3	-0.7	-0.8	-0.2
Ever smoked	6.3	11.0	24.8	-2.1	-4.8	-5.0	4.0	3.4	-4.7	-0.4	-4.0	-3.6	-2.6	-1.5	-0.8	-1.7
Basal metabolic rate	1.8	10.0	26.9	-1.4	4.6	4.4	-4.8	-5.2	4.1	-1.2	2.4	2.8	0.5	-1.1	-1.8	0.7
Leg fat percentage (left)	1.5	5.5	13.0	-1.8	-3.1	-3.6	2.5	2.2	-3.5	-0.5	-3.5	-1.9	-1.8	-1.4	-0.7	0.8
Arm fat-free mass (left)	1.4	7.4	22.5	-1.5	3.8	3.5	-4.2	-4.7	3.1	-1.6	1.6	2.0	-0.2	-1.5	-2.1	0.5
Number of operations (self-reported)	1.5	2.2	6.5	0.7	-2.2	-2.0	1.9	2.5	-1.7	1.2	-1.2	-0.6	0.3	1.0	1.3	0.5
Average weekly beer plus cider intake	0.7	1.0	1.7	1.1	0.6	0.6	-0.6	0.2	0.7	1.1	1.0	1.3	1.3	1.2	1.3	1.0
Irritability	0.4	0.6	2.6	0.9	-0.7	-0.5	1.6	1.0	-0.2	0.8	0.1	0.3	0.8	0.8	0.8	-0.2
Risk taking	0.9	1.3	2.9	0.4	-0.7	-0.5	1.6	1.7	-0.9	1.7	0.2	0.9	0.9	1.4	1.5	1.2
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.4	1.0	-0.8	-0.6	0.9	1.2	-0.3	0.8	0.2	-0.1	0.4	0.8	1.1	0.4
Fractured/broken bones in last 5 years	1.0	1.2	3.3	-1.0	-1.2	-1.4	0.5	0.3	-1.3	-1.2	-1.8	-0.1	-1.2	-1.2	-1.1	-0.9
Age started oral contraceptive pill	0.2	0.3	1.8	0.1	0.4	0.6	-0.8	-0.3	0.3	0.1	0.2	1.4	0.4	0.4	0.2	-0.6
Diastolic blood pressure, automated reading	0.3	0.8	2.8	0.6	0.7	0.5	-1.0	-1.2	0.4	-1.4	-0.7	0.0	-0.3	-0.9	-1.0	1.7
Ever depressed for a whole week	1.7	2.0	4.6	1.7	0.1	0.6	0.1	1.0	0.5	1.7	1.4	1.8	1.7	1.8	1.9	2.1
Unable to work because of sickness or disability	2.2	2.8	6.0	0.1	-2.1	-2.4	2.4	2.4	-2.3	1.0	-1.8	-0.5	-0.5	0.4	0.5	2.1
Commuting to job workplace: Cycle	2.6	3.1	6.9	2.6	1.7	2.0	-1.4	-0.4	1.8	1.3	2.3	2.0	2.0	1.9	1.6	0.4
Myopia	0.6	0.8	3.7	-1.8	-0.0	-0.2	0.1	-0.5	-0.3	-0.3	-0.7	-0.1	-0.9	-0.9	-1.2	-1.9
Vascular/heart problems diagnosed by doctor	1.5	4.0	13.9	-1.1	-2.6	-2.5	2.6	2.1	-2.6	-0.0	-1.6	-1.3	-1.5	-0.2	0.3	-3.7
Cholesterol lowering medication	0.7	1.0	4.5	1.1	-0.6	-0.5	0.3	1.3	-0.2	1.4	-0.2	0.5	1.0	1.0	1.1	2.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	6.1	-2.1	-1.4	-1.8	0.9	0.1	-1.5	-1.4	-2.4	-2.5	-1.4	-1.9	-1.8	0.0
Pain experienced in last month	2.6	4.4	10.5	0.2	3.2	3.2	-2.5	-2.5	2.9	-0.4	2.8	2.2	1.0	0.7	0.2	-0.7
Supplements: Calcium	0.2	0.3	1.4	-0.4	-0.3	-0.4	0.5	0.1	-0.4	0.1	-0.3	-1.2	-0.6	-0.4	-0.4	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	2.4	-0.6	-0.6	-0.5	0.7	0.4	-0.3	0.2	-0.6	0.2	-0.1	-0.1	-0.0	-1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.3	0.5	-0.6	-0.6	0.6	0.7	-0.7	0.6	-0.2	-0.7	-0.1	0.1	0.3	1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.5	-0.2	-1.7	-1.8	1.2	1.6	-2.1	-0.1	-1.1	-0.3	-1.4	-0.5	-0.1	0.5
Heart disease (siblings)	0.5	0.6	1.5	0.6	-0.7	-0.7	1.1	1.2	-0.7	0.7	-0.1	0.4	0.4	0.9	1.0	0.5
Alcohol drinker status: Previous	1.5	1.7	4.5	0.6	-1.2	-0.9	1.6	2.0	-0.8	2.1	0.2	0.6	0.9	1.6	1.9	0.5
Pack years of smoking	0.4	0.6	3.0	-1.7	-0.5	-0.7	0.9	0.1	-0.8	0.1	-1.1	0.2	-0.6	-0.8	-0.9	-0.3
Impedance of whole body	0.4	1.8	4.0	1.4	-0.5	-0.0	0.6	1.7	0.6	1.9	0.8	1.3	1.8	2.0	1.8	-1.1
Leg fat mass (left)	0.4	1.5	5.0	-2.2	-0.9	-1.3	0.4	-0.1	-1.3	-0.8	-2.0	-0.7	-1.2	-1.5	-1.3	0.5
Arm predicted mass (left)	1.5	7.8	23.8	-1.6	3.9	3.6	-4.3	-4.9	3.2	-1.8	1.6	2.3	-0.3	-1.6	-2.2	0.3