Hub : Genes

LINGO1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.04 0.017 1.4e-04 0.043 0.022 0.038 0.022 0.039 5.6e-06 8.6e-04 1.7e-05 9.2e-04 1.3e-05
2 GTEx Artery Tibial 0.08 0.038 3.6e-03 0.041 NA 0.021 NA 0.028 3.4e-04 NA 8.7e-03 NA 2.7e-03
3 GTEx Brain Cerebellar Hemisphere 0.44 0.111 7.5e-04 0.109 NA 0.156 NA 0.237 9.8e-04 NA 8.2e-05 NA 9.2e-07
4 GTEx Brain Cerebellum 0.30 0.092 1.1e-03 0.061 NA 0.155 NA 0.176 7.3e-03 NA 2.5e-05 NA 6.7e-06
5 GTEx Brain Hypothalamus 0.18 0.068 1.9e-03 0.052 NA 0.075 NA 0.075 2.4e-02 NA 7.9e-03 NA 8.1e-03
6 GTEx Lung 0.10 0.038 2.0e-04 0.091 NA 0.047 NA 0.076 1.9e-07 NA 1.6e-04 NA 2.0e-06
7 GTEx Skin Sun Exposed Lower leg 0.07 0.034 4.6e-03 0.047 NA 0.072 NA 0.085 8.4e-05 NA 1.3e-06 NA 1.5e-07
8 GTEx Testis 0.20 0.086 8.1e-03 0.118 NA 0.061 NA 0.086 6.5e-06 NA 1.1e-03 NA 1.1e-04
9 TCGA Breast Normal 0.05 0.014 1.9e-09 0.025 0.030 0.029 0.028 0.030 2.2e-07 1.6e-08 2.1e-08 4.9e-08 1.2e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Alzheimer’s Disease (in mother) 0.7 0.9 2.3 -0.8 0.7 -1.0 -1.4 -1.5 -0.3 0.5 -0.4 -0.8
Alzheimer’s Disease (in father) 1.5 1.6 3.7 -1.3 0.9 0.2 0.6 -1.6 -1.9 0.1 -1.5 -1.7
Alzheimer’s Disease (including proxy) 0.3 0.5 1.2 -0.9 0.5 -0.1 0.3 -1.1 -0.8 -0.0 -0.9 -0.7
Crohns Disease (2017) 2.7 6.0 15.4 -1.0 3.3 0.2 0.5 -3.7 -1.5 3.0 -1.2 -3.9
Irritable Bowel Disease (IBD) 2.1 5.1 10.6 -0.9 2.9 0.1 0.9 -2.8 -1.6 2.7 -2.7 -3.3
Ulcerative Colitis (UC) 1.3 2.4 7.2 -0.3 2.0 -0.1 0.7 -1.0 -0.8 2.1 -2.7 -2.0
Major Depression (MDD) 0.8 1.0 5.1 0.4 -0.4 -0.7 -1.1 1.0 0.4 -0.5 2.3 0.9
Reaction Time 0.5 1.0 2.7 0.2 1.1 -1.5 -1.6 -0.7 -0.3 0.4 1.2 -0.5
Verbal and Numeric Reasoning (VNR) 1.3 3.1 9.2 -1.7 2.1 0.2 0.7 -1.6 -1.0 2.1 -1.8 -3.0
Breast Cancer 0.5 1.1 3.6 -1.3 -1.0 0.3 -0.2 -0.3 -0.8 -1.6 1.9 0.5
Ovarian Cancer 0.2 0.3 0.7 -0.8 0.5 0.4 -0.4 -0.6 -0.4 -0.2 0.8 -0.8
Prostate Cancer 1.7 2.4 5.3 -0.1 2.3 1.6 2.1 -1.1 -0.6 1.6 -1.3 -1.8
Age at First Birth 0.4 0.6 2.3 -0.3 -0.7 0.3 -0.3 -0.6 -0.6 -1.5 0.5 1.1
Bipolar Disorder 1.7 1.7 5.1 -2.1 0.7 0.0 0.5 -1.7 -2.3 -0.8 -0.6 -1.0
Body Mass Index (BMI) (2010) 1.4 2.0 5.3 0.6 1.3 -2.3 -1.5 0.3 1.7 1.2 -1.7 -0.7
Coronary Artery Disease (CAD) 1.4 1.7 3.7 -1.0 1.9 -0.3 -1.0 -1.8 -1.0 0.4 1.5 -1.6
Crohns Disease (2012) 1.8 2.9 6.2 0.7 -2.0 -1.0 -1.1 2.3 1.2 -2.3 1.0 2.5
Mean Putamen Volume 0.3 0.4 1.3 0.6 0.4 -0.5 0.5 -0.2 -0.1 -1.1 0.5 1.0
Fasting Glucose 1.6 1.9 8.4 1.4 0.7 -1.4 -0.5 1.1 2.9 1.7 -0.4 0.1
HbA1C 2.8 3.1 8.1 -0.3 2.8 0.0 -0.3 -2.0 0.7 2.2 -1.6 -2.8
HDL Cholesterol 0.3 0.5 1.4 -0.3 -1.2 0.8 0.7 0.8 -0.2 -0.9 -0.2 0.5
LDL Cholesterol 0.1 0.2 0.9 0.0 0.5 -0.8 -0.9 -0.1 0.0 -0.1 0.3 0.0
Lupus 2.1 3.2 9.4 0.8 -3.1 0.0 -0.1 2.6 1.4 -1.1 1.7 2.4
Neuroticism 1.6 2.3 15.1 0.9 0.7 -0.9 -1.7 0.2 0.6 -0.1 3.9 -0.1
Primary Biliary Cirrhosis 0.9 1.2 4.4 0.6 -2.1 -0.1 0.1 1.4 0.7 -0.8 0.7 1.6
Rheumatoid Arthritis 2.2 3.0 8.4 1.1 -2.6 0.0 -0.6 2.9 2.2 -0.5 1.3 1.9
Schizophrenia 0.8 1.9 4.4 -1.1 1.2 -2.1 -1.3 -0.9 -1.2 1.3 0.8 -1.9
Triglycerides 0.5 0.9 2.4 -0.6 1.0 -1.1 -1.5 -1.0 -1.0 0.3 0.3 -0.8
Type 2 Diabetes (T2D) 1.9 2.3 6.9 2.2 1.6 0.3 0.6 0.6 1.8 2.6 -1.4 -0.5
Ulcerative Colitis 1.4 2.1 7.1 0.4 -1.6 -0.7 -1.4 0.8 0.7 -2.0 2.7 1.4
Blood Eosinophil Count 0.4 3.1 10.7 1.9 3.3 -1.3 -0.9 -0.6 0.8 2.3 -1.4 -1.7
Blood Platelet Count 0.5 5.4 22.6 0.2 2.4 -3.4 -4.8 -1.9 0.1 1.7 1.2 -0.8
Blood Red Count 1.5 15.1 38.6 1.1 6.2 -4.9 -4.2 -2.4 1.1 4.8 -2.2 -4.4
Blood White Count 1.7 12.8 29.7 0.3 5.5 -3.8 -4.2 -3.4 -0.6 4.3 -2.3 -4.2
Heel T-Score 1.2 9.7 25.3 3.2 -4.7 -0.1 -0.9 4.2 2.4 -2.0 1.4 5.0
BMI 0.9 5.5 20.9 1.7 2.9 -1.5 -2.0 0.0 1.0 4.6 -2.6 -1.8
Height 1.9 37.3 118.8 0.5 -10.9 1.4 1.5 8.5 1.4 -7.0 3.3 8.9
Waist Hip Ratio (WHR) 0.6 2.7 9.0 -0.3 1.8 -1.5 -1.3 -1.2 -0.5 3.0 1.2 -2.3
Systolic Blood Pressure 0.5 2.4 7.6 -0.6 2.2 0.6 0.7 -0.7 -0.7 1.7 -2.8 -2.0
Smoking Status 2.6 6.4 12.5 -1.2 2.6 -3.5 -3.5 -2.6 -1.7 2.3 0.3 -3.0
Allergy or Eczema 0.6 1.6 6.6 -1.6 -0.8 -0.6 -0.4 -0.9 -1.6 -2.6 0.7 0.5
Cardiovascular Disease 1.6 5.4 19.5 0.0 4.4 -0.5 -0.6 -2.0 -1.0 3.4 -0.0 -3.4
Hypothyroidism (self reported) 0.2 0.4 1.1 0.7 -0.9 -0.2 0.0 0.6 0.5 -0.2 0.9 1.0
Respiratory disease 0.7 1.6 5.1 0.4 -0.8 -2.3 -2.0 1.2 0.6 -0.3 1.1 1.0
Type 2 Diabetes (T2D) 3.2 6.0 15.4 3.9 2.6 0.0 -0.9 1.8 3.8 3.6 0.1 -0.7
Lung FEV1/FVC ratio 3.4 17.1 37.1 -3.4 6.0 1.8 2.5 -5.6 -3.3 2.6 -3.2 -6.1
Lung FVC 0.6 2.9 7.7 -2.5 0.9 0.4 0.9 -2.7 -2.8 -0.6 -0.4 -1.8
Neuroticism 2.0 4.9 26.2 2.8 -0.3 1.1 -0.1 1.7 1.8 0.9 5.1 1.4
Chronotype (morning person) 1.3 3.1 11.2 1.3 -1.6 0.8 1.1 2.0 2.2 -0.6 -3.3 1.3
Hair Pigment 0.1 4.5 13.5 2.0 -3.0 1.1 1.3 3.7 1.0 -0.4 0.6 3.0
Tanning 0.1 1.5 5.6 -2.4 0.2 -0.3 0.6 -0.9 -2.0 -0.8 -1.1 -0.8
Hand grip strength (left) 2.0 5.4 22.5 2.8 2.0 -1.1 -1.4 -0.5 2.4 2.3 4.7 -0.2
Number of treatments/medications taken 2.1 3.7 9.6 -0.3 -1.8 2.3 3.1 0.4 0.2 -2.1 -3.0 1.4
Average weekly spirits intake 1.0 1.2 6.5 0.6 0.9 1.1 2.5 0.2 0.5 -0.5 -1.3 0.3
Sensitivity / hurt feelings 1.0 1.7 5.3 -1.7 0.9 -0.8 -0.6 -1.1 -1.4 -1.3 -2.3 -0.6
Frequency of depressed mood in last 2 weeks 1.1 1.5 6.0 -1.2 0.9 0.0 0.2 -1.5 -1.5 -1.0 -2.5 -0.3
Hearing difficulty/problems: Yes 1.5 2.3 6.3 1.8 -0.2 1.6 2.5 1.4 1.6 0.2 -1.6 1.2
Relative age of first facial hair 2.5 5.2 10.6 2.1 -2.0 -2.1 -2.3 3.2 3.0 -0.3 1.7 2.4
Other serious medical condition/disability diagnosed by doctor 2.6 3.4 7.2 2.3 -1.4 0.9 0.9 2.7 2.7 -0.7 -1.5 2.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.1 -0.5 -1.0 0.9 0.9 0.2 -0.3 -1.3 -1.8 0.7
Ever had hysterectomy (womb removed) 0.8 0.9 1.9 -1.4 -0.3 1.0 0.6 -0.7 -1.2 0.1 -1.2 -1.1
Systolic blood pressure, automated reading 0.2 0.5 1.5 0.4 -1.1 -0.2 -0.1 0.0 0.9 -0.5 1.2 0.8
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 4.5 -1.3 -0.1 2.1 2.1 -0.7 -1.8 0.2 -0.1 -0.9
Angina 0.5 0.7 1.1 1.0 -0.4 1.1 0.9 0.8 0.8 -0.8 -0.7 0.8
Medication for hormone replacement therapy 0.8 0.8 3.3 -1.5 -1.8 0.9 0.3 0.3 -0.7 -0.4 -0.3 0.6
Vitamin and mineral supplements 1.7 2.3 5.5 -1.5 2.3 0.9 1.5 -1.1 -1.2 1.0 -1.2 -2.3
Supplements: Zinc 0.9 1.0 2.8 -0.6 -0.6 -1.2 -1.7 -0.9 -1.5 -0.7 -0.1 0.2
Medication: Co-codamol 2.1 2.4 5.4 -1.7 2.3 0.0 0.1 -1.8 -1.6 1.3 -0.9 -2.3
Medication: Metformin 2.4 3.4 9.1 -2.8 -1.6 -0.5 0.8 -1.1 -2.8 -3.0 -0.4 0.5
Diabetes (father) 0.2 0.2 1.2 0.1 -0.3 0.3 0.3 -0.1 -0.2 -0.8 -0.1 1.1
Diabetes (mother) 1.7 2.2 7.8 -1.7 -0.8 0.9 2.8 0.0 -1.3 -1.1 -2.2 0.2
Severe depression (siblings) 0.2 0.2 1.0 0.1 0.6 -0.5 -0.3 -0.6 -0.1 0.2 -1.0 -0.3
Pack years adult smoking proportion 1.2 1.9 4.5 -1.7 -0.7 1.7 0.5 -0.7 -1.4 -2.1 1.9 0.2
Impedance of leg (right) 2.8 13.9 35.5 -2.3 6.0 -1.2 -0.9 -4.7 -3.6 3.0 -3.5 -5.1
Leg fat-free mass (left) 0.3 1.6 5.3 -0.6 -1.2 1.3 0.9 -1.0 0.1 -2.3 1.8 0.5
Trunk fat percentage 1.8 7.3 14.8 -3.9 1.2 2.6 2.6 -3.7 -3.3 -2.3 -0.0 -2.5
Hand grip strength (right) 2.6 7.2 20.6 2.4 2.6 -2.4 -3.0 -1.2 2.5 2.7 4.5 -1.1
Townsend deprivation index at recruitment 2.5 3.5 8.0 -1.4 -1.5 2.5 2.7 0.1 -1.6 -2.8 -1.2 1.5
Current tobacco smoking 1.8 2.9 6.9 -1.0 -1.6 2.4 2.6 0.7 -0.5 -2.5 -1.1 1.4
Average weekly fortified wine intake 2.7 3.1 7.6 -1.6 2.3 0.4 0.9 -2.3 -0.7 2.2 -1.2 -2.7
Maternal smoking around birth 1.5 2.2 6.9 -1.9 -2.0 1.1 1.2 -0.4 -0.5 -2.6 1.3 0.9
Fed-up feelings 1.5 2.7 17.2 -1.1 -0.3 0.8 2.2 -0.4 -0.5 -0.4 -4.2 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 10.7 -0.8 1.1 0.1 0.9 -0.8 -0.5 0.4 -3.3 -0.7
Relative age voice broke 0.3 0.5 1.3 -0.1 -0.7 -0.9 -1.1 0.7 0.5 0.6 0.6 0.3
Taking other prescription medications 1.5 2.3 5.3 -2.1 -0.4 0.2 0.5 -1.9 -1.6 -1.9 -2.3 -0.5
Age when periods started (menarche) 2.1 5.0 13.5 2.5 2.8 -1.3 -0.3 0.4 2.7 3.7 -2.7 -1.1
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 3.0 -1.4 -0.5 -1.2 -1.7 -0.6 -0.8 -1.5 -0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 5.2 -2.3 1.8 -0.8 -0.2 -2.0 -1.7 0.5 -0.1 -2.2
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.5 0.7 -0.4 -1.6 -1.5 0.2 -0.6 -1.1 -0.8 1.1
Qualifications: CSEs or equivalent 0.3 0.4 1.0 -1.0 0.3 0.4 0.0 -0.4 -1.0 0.0 -0.1 -0.9
Serious illness, injury or assault to yourself 0.3 0.3 1.4 -0.0 -0.1 0.8 1.2 0.3 0.0 -0.2 0.4 0.6
High blood pressure 1.4 4.1 18.4 -0.4 -4.3 0.6 0.6 1.7 1.4 -2.4 -0.7 2.6
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.5 1.9 -0.4 0.7 0.6 1.9 1.9 1.1 -1.0 0.9
Multivitamins +/- minerals 1.4 1.7 4.3 0.6 -2.1 -0.2 -0.7 1.4 0.7 -1.1 1.7 2.0
Stomach or abdominal pain in last month 0.4 0.5 1.4 0.7 0.2 0.7 1.2 -0.2 0.7 -0.9 -0.5 0.7
Supplements: Glucosamine 1.1 1.4 3.3 1.8 -0.6 -1.5 -1.8 0.6 1.0 0.6 -1.2 0.9
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 5.7 0.6 1.2 0.9 0.8 -0.3 0.6 -0.0 -2.4 0.2
Medication: Atenolol 0.7 0.9 1.6 0.8 -0.6 1.1 1.1 1.3 1.1 0.3 -1.1 0.5
Medication: Levothyroxine sodium 0.4 0.7 4.3 -0.1 -0.5 -0.0 0.1 1.0 0.3 -0.8 -2.1 0.4
Sitting height 0.2 1.7 3.8 1.9 0.3 1.9 1.5 0.2 1.9 1.2 -0.1 0.2
Chronic bronchitis/emphysema (father) 1.0 1.2 4.8 -0.6 -0.2 1.7 2.2 -0.4 -1.3 -0.9 -0.0 0.1
High blood pressure (mother) 1.7 2.4 6.9 0.7 -2.6 1.2 1.1 1.9 0.4 -1.3 1.7 1.9
Body mass index (BMI) 1.7 7.2 24.6 -3.3 -2.8 2.4 2.5 -1.1 -1.9 -5.0 1.8 1.0
Impedance of leg (left) 2.9 14.4 39.3 -1.9 6.3 -0.9 -0.9 -4.5 -3.2 3.6 -3.6 -5.3
Leg predicted mass (left) 0.3 1.6 5.3 -0.5 -1.3 1.3 0.9 -0.9 0.2 -2.3 1.8 0.6
Trunk fat mass 1.4 6.3 13.6 -3.5 0.9 2.5 2.3 -3.7 -2.8 -2.4 0.4 -2.2
Waist circumference 1.5 5.5 19.6 -3.1 -1.5 2.2 2.2 -1.9 -2.0 -4.4 0.8 0.2
Number of incorrect matches in round 0.6 1.1 4.3 -0.5 -1.4 -0.1 -0.5 0.2 -0.8 -2.1 0.8 1.2
Past tobacco smoking 1.8 3.4 6.8 -2.6 0.8 -2.0 -1.5 -2.3 -2.6 0.3 0.3 -2.3
Alcohol usually taken with meals 0.7 1.1 5.4 -0.3 0.4 -1.7 -2.3 -0.8 -0.6 0.3 0.7 -0.4
Nervous feelings 1.4 2.6 15.6 -1.4 1.2 -0.6 -0.4 -1.3 -0.8 -0.1 -4.0 -1.3
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 6.1 -1.4 -1.0 -0.4 -0.1 -0.3 -1.4 -2.5 -1.7 1.4
Hearing difficulty/problems with background noise 0.6 1.0 3.2 0.6 -1.2 1.0 1.4 0.4 0.4 -0.5 -1.8 1.0
Hair/balding pattern: Pattern 2 1.0 1.3 2.7 0.9 -1.7 -1.2 -1.3 1.5 1.2 -0.2 -0.7 0.7
Had menopause 1.1 1.3 3.0 0.2 -1.5 1.2 1.4 1.7 0.6 -0.6 -1.5 0.8
Had other major operations 0.2 0.2 0.5 -0.4 -0.7 -0.5 -0.6 -0.1 -0.1 -0.5 0.1 0.6
Forced vital capacity (FVC) 0.8 3.1 8.3 2.9 2.0 -0.7 -1.2 0.5 2.5 2.5 0.6 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.6 12.0 -2.4 2.5 -0.7 0.2 -3.5 -2.3 0.8 -0.9 -3.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.9 -1.1 0.1 0.3 0.6 -0.9 -1.0 0.0 -1.4 -0.5
Qualifications: None of the above 0.7 1.5 6.8 -0.5 0.3 1.8 2.6 -0.5 -0.4 -0.2 -1.7 -0.3
Financial difficulties in last 2 years 1.1 1.5 4.2 -2.1 -0.4 -1.3 -0.9 -1.7 -1.6 -1.0 0.0 -0.5
Mouth/teeth dental problems 0.7 1.1 2.2 0.4 -1.2 -1.1 -1.3 1.4 0.4 -0.3 1.1 1.5
Heart attack 2.1 2.7 6.6 2.4 -0.2 1.0 1.4 2.0 2.6 1.9 -0.8 0.9
Allergy 0.4 0.9 1.7 -1.3 0.2 -1.1 -0.9 -0.9 -1.3 -0.6 1.2 -0.6
Pain all over the body in last month 1.1 1.1 4.2 -1.2 0.4 0.7 0.3 -1.1 -1.5 -0.7 -2.0 -0.6
Diabetes (self-reported) 2.0 3.1 8.9 -2.9 -1.5 0.0 0.4 -1.4 -2.3 -3.0 0.1 0.7
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 9.8 0.8 3.1 0.3 0.9 -1.4 0.4 1.9 -2.9 -1.8
Medication: Ramipril 0.2 0.3 0.7 -0.3 -0.5 0.3 0.5 -0.3 0.6 -0.9 0.5 0.6
Medication: Simvastatin 1.2 1.8 4.1 0.8 -2.0 1.1 1.0 1.2 0.6 -1.7 -0.8 1.9
Fluid intelligence score 1.8 3.7 9.6 0.5 -2.6 0.8 0.2 1.6 -0.2 -3.0 2.2 3.1
Illnesses of siblings 1.5 2.2 6.6 1.0 1.9 -2.4 -2.6 -0.3 0.2 1.1 0.8 -0.4
Neuroticism score 2.7 5.8 26.5 -3.3 0.9 -0.9 0.2 -2.3 -2.0 -0.7 -5.2 -1.8
Weight 0.9 4.5 9.0 -2.9 -0.1 2.3 2.1 -3.0 -2.0 -2.7 0.7 -1.2
Impedance of arm (right) 1.7 8.3 22.9 0.6 4.8 1.1 1.7 -1.6 -0.9 4.4 -3.1 -3.8
Arm fat percentage (right) 1.4 5.5 11.0 -3.0 -1.2 2.9 3.0 -1.8 -2.3 -3.3 1.4 -0.3
Trunk fat-free mass 0.1 0.6 2.3 -0.1 -0.5 0.5 -0.0 -1.5 0.5 -0.9 1.4 0.1
Hip circumference 1.5 6.4 14.9 -3.6 1.4 1.9 2.1 -3.9 -3.0 -2.2 1.2 -2.3
Time employed in main current job 1.3 1.5 6.8 1.8 -0.5 0.6 0.7 1.3 2.6 0.4 -0.3 0.6
Alcohol intake versus 10 years previously 2.7 4.1 10.8 -1.6 2.2 0.8 0.8 -3.3 -2.1 2.1 -0.2 -2.8
Father’s age at death 0.6 0.8 2.2 1.4 0.1 -1.5 -1.1 0.3 0.7 1.0 0.3 0.3
Worrier / anxious feelings 2.5 4.7 24.6 -2.2 1.2 -0.6 0.9 -2.0 -1.9 -0.1 -5.0 -1.7
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 12.8 -2.0 1.3 0.8 1.8 -2.0 -2.5 -1.0 -3.6 -1.2
Falls in the last year 0.9 1.3 4.4 1.2 -0.5 0.3 0.9 1.1 1.5 -0.2 -2.1 1.0
Hair/balding pattern: Pattern 3 0.5 0.7 3.0 -0.4 1.7 -0.3 -0.4 -0.6 -0.3 1.0 -0.5 -1.2
Number of live births 0.5 0.7 2.0 -0.5 1.1 -0.0 -0.4 -0.9 -0.2 1.4 -0.3 -1.2
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 8.1 2.8 0.7 -1.1 -1.6 1.2 2.7 1.6 1.6 0.4
Pulse rate 0.4 0.7 2.4 -1.6 -1.1 0.7 -0.1 -0.2 -0.7 -1.1 0.7 0.4
Happiness 1.0 1.2 4.0 -1.0 0.0 2.0 1.7 0.1 -0.3 0.1 -1.5 -0.6
Noisy workplace 0.6 0.8 3.0 0.0 0.2 -0.0 0.3 0.2 1.2 1.2 -1.7 -1.0
Qualifications: A levels/AS levels or equivalent 0.4 0.8 3.3 0.4 1.2 0.7 -0.5 -0.4 -0.3 1.1 1.8 -0.5
Serious illness, injury or assault of a close relative in last 2 years 2.7 3.2 8.8 -0.0 -3.0 -1.0 -1.4 2.1 0.5 -2.1 1.1 2.5
Mouth/teeth dental problems: Dentures 0.7 1.1 3.3 -0.1 1.0 0.6 1.2 -1.4 0.5 1.2 -0.6 -1.8
Asthma 0.8 1.6 4.9 -1.2 1.6 0.6 -0.1 -2.2 -1.4 0.1 -0.9 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 3.8 -0.7 -0.1 -0.6 -0.1 -0.2 -0.7 -1.9 0.0 0.9
Medication: Cholesterol lowering 0.8 1.2 4.2 0.8 -1.5 0.3 0.4 0.9 1.3 -0.1 -2.1 0.9
Depression (self-reported) 0.4 0.5 1.7 0.9 1.1 -0.8 0.1 -0.2 0.4 0.1 -1.3 -0.0
Medication: Lansoprazole 1.2 1.3 5.7 -1.2 -0.9 0.4 1.1 -0.5 -1.4 -2.4 -0.4 0.6
Prospective memory result 1.2 1.5 3.9 -1.3 -0.1 1.7 2.0 -0.6 -0.6 -0.4 -1.8 -0.8
Lung cancer (father) 2.0 2.3 8.0 -2.8 0.1 0.1 0.2 -1.1 -2.8 -1.4 1.0 -0.9
Illnesses of mother 5.2 6.5 23.2 -0.2 3.0 -3.5 -4.8 -1.8 0.4 2.1 0.6 -2.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 5.5 2.3 1.2 -0.6 -0.6 0.8 2.3 1.9 0.4 -0.1
Pulse wave Arterial Stiffness index 1.8 2.1 5.9 0.2 -2.4 1.7 1.1 1.9 1.4 -1.0 -0.5 1.6
Impedance of arm (left) 2.3 10.8 33.2 0.2 5.8 0.9 1.3 -2.1 -1.1 4.9 -3.1 -4.7
Arm fat mass (right) 1.3 5.6 13.1 -2.9 -1.1 2.8 2.7 -2.3 -2.1 -3.6 1.5 -0.4
Trunk predicted mass 0.1 0.6 2.0 0.1 -0.5 0.5 0.0 -1.4 0.6 -0.9 1.4 0.2
Standing height 1.1 11.1 33.5 0.5 5.8 0.1 -0.5 -4.5 -0.3 4.2 -2.3 -4.8
Length of working week for main job 3.3 3.7 11.6 -3.4 1.0 -0.4 -0.6 -2.9 -2.4 0.2 -0.5 -2.4
Exposure to tobacco smoke at home 1.0 1.2 2.8 -1.4 1.3 -0.6 0.6 -0.5 -0.7 0.4 -1.7 -1.5
Breastfed as a baby 1.9 2.4 5.4 2.0 -0.7 -2.0 -1.9 1.5 2.3 0.9 -0.1 0.7
Tense / ‘highly strung’ 0.6 1.0 4.4 -1.0 -0.4 -0.1 -0.1 -0.3 -0.6 -1.6 -2.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 4.1 0.0 0.8 -1.6 -0.7 -0.2 0.5 0.7 -2.0 -0.2
Hair/balding pattern: Pattern 4 0.6 1.4 4.8 0.2 -0.4 1.8 2.2 -0.8 -0.3 -1.5 -0.1 1.1
Birth weight of first child 0.5 0.8 2.6 1.3 -0.6 1.0 1.6 0.2 0.6 -0.5 -0.5 1.1
Peak expiratory flow (PEF) 2.3 5.4 15.1 3.9 0.3 -0.6 -1.3 1.9 3.9 1.9 2.8 1.3
Pulse wave reflection index 0.2 0.3 0.5 -0.1 -0.5 0.6 -0.0 0.7 0.4 -0.7 -0.6 0.7
Ever highly irritable/argumentative for 2 days 1.8 2.2 7.2 -0.9 -0.8 2.7 2.6 -0.8 -1.4 -1.1 0.6 0.3
Loud music exposure frequency 0.7 0.8 4.1 -0.3 -0.2 -1.2 -0.6 -0.0 -0.8 -0.5 2.0 0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 -0.3 0.3 -0.9 -0.9 0.5 -0.2 -0.4 0.8 0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 -0.5 1.1 -0.2 -0.6 -0.8 -1.1 0.1 0.3 -1.1
Blood clot in the leg (DVT) 0.3 0.4 1.2 0.1 -0.6 -0.6 -0.2 -0.3 -0.2 -1.1 -0.8 0.9
Medication: Paracetamol 1.7 2.9 7.3 -1.7 0.9 1.0 2.1 -2.0 -2.1 -0.5 -2.7 -1.0
Headache pain in last month 0.8 1.5 4.5 -2.1 0.5 0.0 0.7 -1.7 -1.8 -1.1 0.1 -0.7
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 4.7 -1.1 2.2 -1.0 -1.1 -1.1 -1.5 1.1 1.6 -2.0
Glaucoma (self-reported) 0.3 0.3 0.7 0.5 -0.2 0.8 0.7 0.2 0.8 -0.1 -0.8 0.0
Gout (self-reported) 0.3 0.5 2.6 0.4 -0.4 1.6 0.6 -0.4 0.7 0.3 0.4 0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 1.1 -0.3 -0.0 0.3 0.1 0.2 0.1 -0.1 -1.0 -0.4
Medication: Amlodipine 1.3 1.8 5.5 1.0 -2.3 0.1 -0.0 1.9 2.1 0.1 0.5 1.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.0 0.1 -0.2 0.3 -0.4 -0.5 -0.1 -0.5 -0.3
Birth weight 1.3 2.7 6.6 2.4 2.1 0.1 0.9 0.2 2.3 2.6 0.5 -1.3
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.0 -1.8 0.2 0.4 0.4 -1.5 -2.0 -1.4 0.9 0.1
High blood pressure (siblings) 0.9 1.4 4.6 -0.1 -2.2 1.4 1.4 1.0 1.0 -0.8 -0.2 0.9
Forced vital capacity (FVC), Best measure 0.7 2.8 8.2 1.9 2.9 -0.3 -0.2 -0.4 1.7 2.7 -0.8 -1.3
Body fat percentage 1.9 7.5 16.6 -4.1 0.5 2.6 2.5 -3.6 -3.4 -3.0 0.4 -1.9
Leg fat percentage (right) 2.5 9.3 24.7 -5.0 -0.0 1.9 1.9 -3.9 -4.3 -3.9 0.1 -1.7
Arm fat-free mass (right) 0.3 1.5 4.5 -0.9 -0.8 0.3 -0.4 -1.9 -0.1 -2.1 1.8 0.2
Exposure to tobacco smoke outside home 1.1 1.5 4.5 -1.6 0.7 -1.0 0.4 -2.1 -1.5 -0.6 0.7 -1.3
Comparative body size at age 10 0.4 1.2 2.1 1.3 -0.6 1.4 1.4 0.8 1.0 -0.9 1.2 0.8
Number of full brothers 0.8 1.0 3.1 -1.8 -0.1 0.0 -0.2 -1.5 -1.5 -0.6 0.9 -0.6
Worry too long after embarrassment 3.4 5.8 13.3 -3.4 0.8 -2.4 -1.3 -2.6 -2.7 -1.5 -3.6 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 10.8 1.5 0.5 0.5 1.3 0.8 1.8 0.7 -3.3 0.3
Wheeze or whistling in the chest in last year 0.6 1.1 2.5 -0.6 0.8 1.1 1.6 -1.5 -1.3 -0.7 -0.9 -0.5
Number of children fathered 0.4 0.4 2.0 0.8 0.0 0.1 1.0 0.2 0.3 1.4 -0.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.6 0.6 -0.2 -1.1 -1.3 -0.1 0.1 -0.8 0.8 0.6
Age at first live birth 0.7 1.3 4.2 2.0 1.0 -1.2 -1.2 0.4 1.5 1.0 -0.1 0.1
Pulse wave peak to peak time 2.4 2.8 7.8 -0.2 2.8 -1.9 -1.4 -2.3 -1.5 1.1 0.4 -1.8
Health satisfaction 1.1 1.4 4.1 -2.0 -0.7 1.4 0.8 -0.2 -0.8 -2.0 -0.8 0.0
Shortness of breath walking on level ground 0.6 0.7 2.5 -1.1 -0.1 1.0 1.0 -0.6 -0.4 -1.6 0.3 -0.2
Qualifications: College or University degree 0.1 0.5 3.2 0.2 0.2 0.5 0.2 0.4 -0.4 0.4 -1.8 0.4
Eye problems/disorders: None of the above 0.3 0.4 1.1 -0.2 -0.9 -0.4 -1.0 -0.4 -0.6 -0.4 0.8 0.3
Mouth/teeth dental problems: Loose teeth 0.0 0.1 0.3 -0.1 -0.1 -0.0 0.1 0.2 0.1 -0.2 -0.6 0.1
Emphysema/chronic bronchitis 0.9 1.0 2.6 0.2 -0.7 0.9 0.9 0.2 -0.2 -1.6 1.4 1.4
Medication for pain relief, constipation, heartburn 0.9 1.6 4.7 1.0 1.5 -0.5 -1.2 0.0 0.8 2.2 1.7 -1.2
Neck or shoulder pain in last month 1.0 1.4 3.9 0.0 -2.0 1.0 1.3 0.9 1.0 -1.3 0.4 1.4
Medication: Blood pressure 1.5 2.7 7.0 1.5 -2.6 1.2 1.4 1.6 1.7 -0.7 -0.6 2.3
Angina (self-reported) 0.7 0.9 1.4 1.0 -0.5 1.2 1.1 1.0 0.8 -0.9 -0.6 0.9
Migraine (self-reported) 0.3 0.4 1.1 -1.0 -0.5 0.5 0.5 -0.1 -0.8 -0.9 0.1 0.0
Medication: Ibuprofen 1.0 1.2 5.2 -1.1 -0.2 -1.0 -0.3 -0.6 -1.3 -2.3 -0.4 0.9
Medication: Allopurinol 0.2 0.2 0.7 0.0 -0.5 0.1 -0.7 0.1 0.8 0.3 0.8 0.1
Medication: Omeprazole 1.6 1.9 6.5 -1.6 0.7 1.3 1.3 -0.7 -1.6 0.0 -2.5 -1.0
Medication: Seretide 50 evohaler 1.6 1.9 4.4 1.5 -2.1 1.4 0.9 1.4 1.1 -0.8 0.3 1.8
Mean time to correctly identify matches 1.3 2.5 4.8 0.4 -1.9 2.0 2.0 1.6 1.2 -0.5 -2.2 1.0
Heart disease (mother) 1.5 1.8 6.4 -0.5 -0.6 2.1 2.5 0.3 0.1 -0.9 -2.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 8.3 2.5 1.0 -0.9 -1.4 0.3 2.9 1.4 1.5 0.2
Whole body fat mass 1.4 6.2 12.3 -3.5 0.1 2.6 2.3 -3.4 -2.7 -3.2 0.7 -1.4
Leg fat mass (right) 1.7 6.8 14.7 -3.8 -0.5 2.2 2.0 -3.4 -3.1 -3.8 0.9 -1.0
Arm predicted mass (right) 0.3 1.8 5.7 -1.1 -0.8 -0.1 -0.8 -2.1 -0.4 -2.4 1.8 0.2
Pulse rate, automated reading 1.1 3.5 10.2 0.4 -3.2 0.9 0.5 2.6 0.7 -2.0 0.8 2.8
Alcohol intake frequency. 4.5 10.7 24.4 -4.5 2.6 0.7 1.8 -4.2 -4.9 1.6 -0.9 -4.5
Comparative height size at age 10 0.9 4.9 14.4 -0.5 3.8 1.3 1.6 -2.9 -1.1 1.4 -2.0 -3.1
Number of full sisters 2.5 3.0 11.4 -2.7 -0.3 0.0 0.1 -2.1 -3.4 -1.1 1.6 -0.3
Suffer from ‘nerves’ 2.0 3.2 14.9 -1.4 1.6 -1.6 -1.0 -1.8 -0.9 0.1 -3.9 -1.3
Overall health rating 2.3 4.9 16.3 -0.5 -0.8 3.1 4.0 0.3 -0.0 -2.2 -3.4 0.7
Chest pain or discomfort 0.3 0.4 1.5 0.3 0.0 0.3 0.7 0.2 -0.2 -0.9 -1.2 0.8
Had major operations 0.5 0.6 1.2 -1.0 0.8 -1.1 -1.1 -1.0 -0.4 -0.5 0.2 -0.3
Age at last live birth 1.0 1.5 4.6 -0.5 2.2 -1.4 -1.3 -1.2 -0.3 1.1 0.2 -1.5
Family relationship satisfaction 0.6 0.8 1.5 -1.0 -0.8 1.2 1.0 0.1 -0.9 -0.8 1.2 0.1
Leg pain on walking 0.3 0.4 1.3 0.7 0.1 -0.0 -0.1 0.3 1.1 0.8 -1.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.2 -1.1 0.1 0.1 -0.3 -1.3 -0.7 0.1 0.5 -1.5
Commuting to job workplace: Car/motor vehicle 0.6 0.7 4.0 -0.2 0.4 -1.0 -2.0 -0.3 -0.4 -0.1 0.9 -0.3
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 4.6 0.7 2.2 0.8 0.7 -0.8 0.7 1.4 -0.4 -1.7
Medication: Aspirin 3.8 5.0 9.5 2.4 -3.0 0.9 1.2 3.1 2.4 -1.6 -0.9 3.1
Supplements: Vitamin C 0.5 0.5 2.3 0.5 -0.5 -1.3 -1.5 0.0 0.3 0.0 0.4 0.3
Knee pain experienced in last month 0.4 0.5 1.4 0.5 -0.2 -0.9 -1.2 0.3 0.4 0.9 -1.1 -0.3
Hypertension (Self-reported) 1.4 3.9 16.8 0.1 -4.1 0.6 0.8 1.8 1.7 -2.0 -0.6 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.8 -1.7 -0.9 0.4 0.4 -0.3 -0.7 -2.0 -0.1 0.2
Illnesses of father: Heart disease 2.1 2.9 6.4 1.6 -2.4 -1.1 -1.3 2.4 1.4 -0.9 -0.1 2.5
Illnesses of siblings: Diabetes 1.6 2.0 5.2 -1.7 -1.3 2.0 2.3 -0.4 -1.7 -0.9 0.0 -0.0
Smoking status: Previous 1.7 2.5 6.9 2.5 -0.7 1.4 0.7 2.0 2.6 0.7 -0.4 1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 0.8 0.8 -0.7 -1.2 0.7 1.3 1.3 -0.3 -0.6
Whole body fat-free mass 0.2 1.0 3.1 -0.3 -0.9 0.7 0.2 -1.3 0.3 -1.7 1.8 0.4
Leg fat-free mass (right) 0.3 1.4 3.8 -0.1 -1.3 1.4 0.8 -0.6 0.6 -1.9 2.0 0.7
Arm fat percentage (left) 1.4 5.8 11.2 -3.3 -0.7 2.9 3.0 -2.2 -2.5 -3.1 1.3 -0.9
Average weekly red wine intake 0.1 0.1 0.5 -0.7 -0.1 0.2 -0.1 -0.6 -0.5 -0.2 0.0 -0.2
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 0.4 0.6 -0.9 0.5 -0.2 0.0 0.2 0.1 0.4
Mood swings 1.1 2.0 11.4 -1.5 -0.8 0.3 1.3 -0.7 -0.6 -0.9 -3.4 -0.2
Loneliness, isolation 1.0 1.3 6.8 -0.3 -0.1 1.2 1.7 0.0 0.6 0.4 -2.6 -0.3
Long-standing illness, disability or infirmity 1.3 2.0 4.5 0.0 -1.0 2.1 2.0 0.3 0.1 -1.7 -2.0 1.3
Ever had bowel cancer screening 1.1 1.3 5.9 1.4 0.0 -1.1 -0.9 -0.0 1.1 0.2 -2.4 0.7
Diabetes diagnosed by doctor 2.6 4.3 12.5 -3.5 -1.6 -0.0 0.6 -1.9 -3.1 -3.1 -0.2 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.2 -0.1 -0.4 0.2 0.1 -0.2 0.4 1.1 -0.9 -0.5
Friendships satisfaction 0.7 0.8 2.0 -0.8 -0.7 1.4 0.8 -0.1 -1.2 -1.3 0.2 0.5
Qualifications: nursing, teaching 0.3 0.4 1.4 1.2 -0.8 0.0 -0.3 0.8 0.3 0.3 0.6 0.8
Commuting to job workplace: Walk 0.3 0.3 1.3 0.2 0.6 -0.6 -0.2 -0.0 -0.3 0.2 -1.1 0.5
Eye problems/disorders: Cataract 1.1 1.2 4.7 1.3 0.4 -1.3 -0.4 1.5 2.2 0.3 -0.0 0.8
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 4.3 -1.0 1.9 1.2 1.0 -1.7 -1.5 0.2 -2.1 -1.5
Medication for cholesterol 1.8 2.7 8.1 1.7 2.7 -1.5 -1.0 -0.4 0.9 2.8 -0.3 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.9 -0.4 0.4 0.9 -0.1 -0.3 -0.1 0.7 -0.1 -1.0
Back pain experienced in last month 1.5 2.1 6.9 -1.7 0.0 0.9 1.4 -1.7 -1.8 0.1 -2.6 -0.8
Mineral and other dietary supplements 0.7 1.0 2.3 -1.5 0.4 0.9 1.5 -1.0 -0.6 -0.3 0.7 -1.2
Breast cancer (self-reported) 0.3 0.3 0.8 -0.3 -0.7 -0.6 0.1 0.8 0.4 -0.9 0.1 0.6
Asthma (self-reported) 0.6 1.2 3.8 -0.8 1.5 0.8 0.2 -2.0 -1.1 0.2 -0.8 -1.3
Osteoporosis (self-reported) 1.2 1.5 5.5 1.5 0.3 -2.0 -2.3 0.6 0.8 0.3 0.7 0.2
Osteoarthritis (self-reported) 0.6 0.8 5.5 -0.2 -1.0 0.3 0.1 0.2 -0.3 -0.9 -2.4 -0.1
Medication: Aspirin 4.3 5.7 12.0 2.9 -3.0 0.7 1.1 3.5 2.9 -1.3 -0.2 3.2
Medication: Gliclazide 0.4 0.5 1.2 0.3 -0.7 -0.9 0.0 -0.1 -0.2 -0.9 -1.1 1.0
Illnesses of father: None of the above (group 1) 1.1 1.3 4.3 -0.1 2.1 0.0 -0.5 -2.0 -0.4 0.5 -0.6 -1.5
Smoking status: Current 1.5 2.4 5.4 -0.7 -1.4 2.2 2.3 0.8 -0.2 -2.2 -0.9 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 1.0 -0.2 -1.5 -1.4 0.5 0.4 -1.0 0.5 1.1
Whole body water mass 0.2 1.1 3.3 -0.4 -1.0 0.8 0.2 -1.3 0.3 -1.7 1.8 0.4
Leg predicted mass (right) 0.2 1.3 3.6 -0.2 -1.2 1.3 0.8 -0.6 0.5 -1.8 1.9 0.6
Arm fat mass (left) 1.4 5.7 11.6 -3.3 -0.7 2.7 2.6 -2.6 -2.3 -3.4 1.4 -0.9
Number of self-reported non-cancer illnesses 1.3 2.3 6.1 -1.4 -1.6 1.2 1.4 -0.6 -0.7 -2.5 -2.1 0.9
Average weekly champagne plus white wine intake 1.2 1.6 4.5 -0.7 1.6 -0.3 -1.1 -2.1 -1.0 0.2 1.5 -1.5
Miserableness 1.8 3.2 26.0 -0.4 0.6 0.3 1.3 -0.2 0.0 -0.1 -5.1 -0.4
Guilty feelings 2.4 3.7 27.5 -1.1 1.2 -0.8 0.1 -1.1 -0.5 -0.5 -5.2 -0.9
Wears glasses or contact lenses 1.9 2.1 6.6 1.6 -1.2 -1.3 -1.2 1.7 2.6 -0.3 0.5 1.5
Ever taken oral contraceptive pill 0.9 0.9 3.4 -0.1 1.5 -1.1 -1.8 -0.3 -0.0 0.6 1.1 -0.2
Hearing aid user 0.8 0.9 2.7 1.0 -0.1 0.6 1.6 0.7 1.4 0.7 -0.8 0.5
Mother’s age at death 0.5 0.7 3.2 0.9 0.4 -1.8 -1.1 0.6 0.2 0.5 -0.1 0.3
Financial situation satisfaction 3.3 4.1 13.9 -3.7 0.0 0.1 0.8 -2.5 -3.4 -1.4 -0.5 -1.3
Tinnitus: Yes, now most or all of the time 2.0 2.3 4.9 2.2 -0.8 0.3 0.8 2.2 2.2 -0.4 -1.3 1.9
Commuting to job workplace: Public transport 1.2 1.4 5.8 0.8 -0.4 2.4 2.1 0.9 0.4 0.5 -0.4 0.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.8 0.6 0.3 1.4 1.0 0.0 0.9 0.2 -0.9 -0.4
Medication: Blood pressure 0.7 1.4 5.8 -1.2 -2.4 0.6 0.3 0.6 -0.1 -1.9 0.2 0.9
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.0 -0.2 0.0 -1.1 -0.7 -0.4 -0.2 1.4 -0.7 -1.1
Supplements: Fish oil (including cod liver oil) 1.3 1.7 4.5 1.7 -1.4 -0.3 -0.2 2.1 1.3 0.0 -0.5 2.1
High cholesterol (Self-reported) 0.7 1.2 2.2 0.7 -1.5 0.8 1.0 0.9 0.4 -1.0 -1.4 1.5
Medication: Bendroflumethiazide 0.6 0.9 2.7 0.4 -1.6 -0.3 0.3 1.0 0.9 -0.3 -1.2 1.1
Medication: Paracetamol 2.6 4.0 7.5 -1.9 1.1 1.8 2.7 -2.6 -2.2 -0.2 -2.7 -1.4
Medication: Lisinopril 2.5 3.2 7.1 1.7 -2.0 1.6 1.6 2.0 1.4 -1.8 0.4 2.7
Medication: Atorvastatin 0.4 0.5 1.4 -0.8 0.1 0.7 0.6 -0.8 -0.8 -0.1 -1.2 -0.5
Illnesses of father: High blood pressure 0.6 0.7 1.7 0.1 -1.3 -0.3 -0.8 0.9 0.8 1.0 1.2 0.0
Alcohol drinker status: Never 4.3 5.1 11.7 -3.0 1.8 -0.8 0.2 -3.4 -3.1 0.9 -1.4 -3.0
Ever smoked 1.3 2.4 5.1 1.8 -0.7 1.9 1.6 1.3 1.5 -1.1 -1.1 2.3
Basal metabolic rate 0.3 1.5 3.9 -0.9 -0.7 1.2 0.7 -1.8 -0.3 -2.0 1.6 -0.0
Leg fat percentage (left) 2.2 8.2 21.5 -4.6 -0.1 2.1 1.8 -3.6 -4.0 -3.7 0.2 -1.6
Arm fat-free mass (left) 0.4 2.1 7.7 -1.3 -1.3 0.5 -0.0 -1.9 -0.6 -2.8 1.7 0.6
Number of operations (self-reported) 0.3 0.5 2.2 -0.6 0.2 -0.8 -1.5 -0.4 -0.1 -0.6 -0.3 0.8
Average weekly beer plus cider intake 0.5 0.7 3.4 -0.6 -0.7 -0.7 -1.0 0.3 0.2 -0.5 1.8 -0.1
Irritability 1.2 2.1 4.7 -1.8 -1.4 1.8 2.2 -0.1 -1.7 -1.0 -1.5 0.2
Risk taking 0.4 0.6 1.5 -1.0 -0.2 1.0 0.1 -0.8 -0.1 -1.2 1.2 0.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.5 0.2 0.7 -0.2 -0.5 0.1 0.5 0.0 0.4 0.2
Fractured/broken bones in last 5 years 0.8 1.1 5.1 0.9 1.3 -1.2 -2.3 -0.2 0.3 -0.3 0.3 0.5
Age started oral contraceptive pill 1.9 2.4 7.3 0.6 2.6 -0.1 0.2 -1.4 -0.3 1.5 -2.7 -1.7
Diastolic blood pressure, automated reading 1.1 3.5 12.4 -0.6 -3.5 0.9 -0.0 1.4 0.4 -2.3 2.2 2.3
Ever depressed for a whole week 0.6 0.7 1.7 -0.5 -0.9 0.7 1.3 0.7 -0.3 -0.7 -1.3 0.7
Unable to work because of sickness or disability 0.7 0.9 2.8 -0.6 -0.0 1.6 1.7 -1.0 -1.1 -0.5 -0.7 0.1
Commuting to job workplace: Cycle 0.7 0.8 4.1 1.1 0.6 0.4 0.2 0.3 0.8 2.0 -0.8 -0.5
Myopia 0.3 0.4 1.0 -0.9 -1.0 0.3 0.5 0.2 -0.8 -0.4 0.8 0.3
Vascular/heart problems diagnosed by doctor 1.2 3.4 14.5 -0.0 3.8 -0.9 -0.8 -1.6 -1.7 1.8 0.9 -2.2
Cholesterol lowering medication 1.2 1.7 6.8 -0.3 -1.6 1.1 1.0 0.7 -0.4 -2.6 0.6 1.6
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 5.3 -1.6 0.5 0.9 1.1 -0.9 -1.9 -0.4 -2.3 -0.7
Pain experienced in last month 0.3 0.4 1.5 0.9 -0.1 0.0 -0.5 1.0 0.6 0.2 1.2 0.3
Supplements: Calcium 0.5 0.6 1.7 1.3 0.1 1.0 0.0 0.1 -0.1 1.0 -1.2 -0.1
Basal cell carcinoma (self-reported) 1.8 2.2 7.7 1.4 -0.8 2.8 2.5 0.9 0.4 0.4 -0.9 0.8
Heart attack/myocardial infarction (self-reported) 2.3 3.0 7.8 2.4 -0.2 1.0 1.3 2.1 2.8 2.1 -0.9 0.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.2 0.3 -0.7 -0.6 -0.3 -0.3 -0.2 -1.1 -0.4 1.1
Heart disease (siblings) 0.5 0.6 1.5 0.7 -0.7 0.2 0.2 0.9 1.2 -0.3 -1.1 0.7
Alcohol drinker status: Previous 0.1 0.1 0.5 -0.7 -0.3 0.0 0.4 -0.1 -0.4 -0.2 0.5 -0.1
Pack years of smoking 1.3 2.0 4.7 -1.6 -0.9 1.8 0.5 -0.6 -1.2 -2.2 1.9 0.3
Impedance of whole body 2.2 11.3 36.1 -0.7 6.0 -0.3 0.1 -3.2 -2.2 4.0 -3.2 -4.8
Leg fat mass (left) 1.6 6.5 14.3 -3.7 -0.6 2.3 1.9 -3.3 -2.9 -3.8 1.0 -1.0
Arm predicted mass (left) 0.4 2.0 7.4 -1.3 -1.3 0.5 -0.0 -1.9 -0.6 -2.7 1.7 0.6