Hub : Genes

LRP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.04 0.021 8.1e-06 0.046 0.037 0.020 0.036 0.042 2.4e-06 2.4e-05 1.5e-03 2.8e-05 6.6e-06
2 GTEx Artery Tibial 0.06 0.034 9.2e-03 -0.004 NA -0.003 NA -0.003 9.9e-01 NA 6.4e-01 NA 6.4e-01
3 GTEx Cells EBV-transformed lymphocytes 0.68 0.092 2.9e-03 -0.003 NA -0.009 NA -0.005 4.2e-01 NA 8.8e-01 NA 5.0e-01
4 GTEx Nerve Tibial 0.28 0.063 0.0e+00 0.235 NA 0.295 NA 0.288 1.2e-16 NA 3.5e-21 NA 1.1e-20
5 GTEx Pancreas 0.11 0.043 1.9e-06 0.097 NA 0.139 NA 0.125 6.9e-05 NA 1.8e-06 NA 6.3e-06
6 GTEx Skin Not Sun Exposed Suprapubic 0.13 0.056 1.2e-03 0.004 NA 0.016 NA 0.018 1.8e-01 NA 4.3e-02 NA 3.5e-02
7 GTEx Spleen 0.15 0.083 7.2e-03 0.141 NA 0.059 NA 0.117 1.9e-04 NA 1.3e-02 NA 6.5e-04
8 GTEx Testis 0.17 0.076 8.0e-03 0.005 NA -0.006 NA -0.006 1.9e-01 NA 7.8e-01 NA 7.8e-01
9 ROSMAP Brain Pre-frontal Cortex 0.04 0.017 7.3e-06 0.058 0.051 0.051 0.050 0.049 6.2e-08 3.5e-07 3.9e-07 4.3e-07 6.5e-07
10 TCGA Breast Tumor 0.28 0.115 5.9e-03 0.011 0.080 0.038 NA 0.026 1.7e-01 6.8e-03 4.7e-02 NA 8.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Alzheimer’s Disease (in mother) 0.6 0.7 1.9 1.0 -0.5 -1.2 0.9 -0.0 -0.4 -1.4 -0.1 -0.0 -1.2
Alzheimer’s Disease (in father) 0.5 0.6 2.1 -0.0 1.2 0.4 0.7 -0.7 0.1 1.4 0.5 0.7 -0.0
Alzheimer’s Disease (including proxy) 0.4 0.5 2.2 0.6 0.7 -0.5 1.0 0.2 0.8 -0.1 0.4 0.0 -1.5
Crohns Disease (2017) 0.3 0.7 1.7 0.2 1.2 -0.7 1.3 -0.4 -0.4 0.8 0.5 1.1 -0.9
Irritable Bowel Disease (IBD) 0.1 0.3 1.4 0.1 0.8 0.0 0.5 -0.1 -0.1 0.5 -0.4 0.6 -1.2
Ulcerative Colitis (UC) 0.2 0.3 0.8 -0.3 0.7 0.9 -0.2 0.0 0.2 0.9 -0.7 0.1 -0.5
Major Depression (MDD) 1.3 1.6 4.6 -1.2 1.4 -1.4 -0.6 1.0 1.0 -0.6 2.1 -1.6 -0.6
Reaction Time 9.4 18.2 29.2 5.1 -4.1 -4.9 4.3 -4.9 3.0 -5.4 -3.8 3.1 3.2
Verbal and Numeric Reasoning (VNR) 2.4 5.8 20.0 -1.9 4.1 1.4 0.7 0.9 1.8 4.5 3.3 0.6 0.4
Breast Cancer 0.8 2.1 9.9 -1.4 1.4 0.1 -0.4 1.8 -1.5 0.2 0.1 -1.0 -3.1
Ovarian Cancer 1.0 1.3 4.6 0.8 0.1 2.2 0.4 -0.7 0.1 1.5 -0.3 1.9 0.8
Prostate Cancer 1.4 2.0 9.2 -1.1 0.6 2.0 -0.9 1.7 -0.2 0.9 -0.8 0.1 -3.0
Age at First Birth 0.6 0.9 2.5 -1.1 0.5 1.2 -0.9 1.1 -0.6 1.6 1.1 -0.7 -0.4
Bipolar Disorder 0.8 0.8 1.7 1.3 -0.1 -0.7 1.2 -1.0 1.2 -0.8 -0.3 1.0 0.7
Body Mass Index (BMI) (2010) 1.3 1.8 9.2 -0.3 -1.9 -0.3 -1.5 0.4 -3.0 -1.0 -0.2 -1.2 -0.4
Coronary Artery Disease (CAD) 0.2 0.2 0.5 0.3 -0.2 -0.4 -0.7 0.2 -0.1 -0.7 -0.2 -0.6 -0.3
Crohns Disease (2012) 0.4 0.7 3.0 0.4 -1.0 -0.3 -0.6 -0.2 0.1 -1.7 0.2 -0.7 1.3
Mean Putamen Volume 1.9 2.2 9.8 1.5 -1.9 -1.8 0.8 -1.0 -0.1 -3.1 -1.3 0.2 -0.2
Fasting Glucose 6.4 7.7 20.9 2.3 0.3 -0.5 3.1 -4.4 1.8 0.6 -0.7 4.1 4.6
HbA1C 0.5 0.5 2.0 -0.3 0.8 0.5 0.4 -0.4 1.2 1.4 0.0 0.6 0.4
HDL Cholesterol 13.9 23.0 60.0 4.1 2.2 0.4 6.9 -5.7 5.3 3.3 -2.5 7.7 4.9
LDL Cholesterol 2.7 4.3 10.7 -1.1 0.1 3.3 -2.5 3.0 -2.3 2.4 0.4 -1.0 -1.8
Lupus 1.5 2.3 9.3 -0.5 1.9 1.3 1.0 -0.8 1.5 3.0 -0.1 1.4 1.4
Neuroticism 5.2 7.7 14.9 -3.6 3.9 1.0 -1.9 3.0 0.5 3.4 3.2 -2.8 -2.3
Primary Biliary Cirrhosis 2.8 4.0 9.4 1.7 0.2 -2.8 2.6 -2.6 3.1 -1.4 -0.3 1.1 1.8
Rheumatoid Arthritis 1.5 2.1 5.9 -0.6 0.2 2.4 -1.6 1.5 -2.4 -0.0 0.9 -0.1 -1.7
Schizophrenia 4.0 8.9 34.5 2.1 -0.3 -5.9 3.2 -3.0 3.1 -4.3 -0.1 0.1 1.7
Triglycerides 4.5 7.5 15.8 -2.6 0.0 1.8 -3.2 4.0 -3.5 0.2 2.1 -3.0 -3.6
Type 2 Diabetes (T2D) 0.9 1.1 2.0 1.2 -1.2 -0.9 1.4 -1.4 -0.3 -1.1 -0.3 1.3 -0.3
Ulcerative Colitis 0.4 0.6 2.5 -0.3 -0.4 -0.1 -0.4 0.7 -1.6 -0.9 1.3 -0.4 0.0
Blood Eosinophil Count 0.3 2.1 8.4 1.1 -0.0 1.3 0.5 -0.3 -2.4 -0.5 -1.5 0.9 -2.9
Blood Platelet Count 2.6 30.0 121.0 -0.4 5.8 -6.8 6.3 -4.9 11.0 1.3 0.3 1.5 5.7
Blood Red Count 0.3 2.7 12.0 0.5 -0.2 1.6 1.0 -0.8 -1.7 1.4 -3.5 2.4 -0.0
Blood White Count 0.9 6.8 44.8 0.3 -1.8 0.4 -1.7 1.0 -6.7 -2.6 -0.3 -1.0 -2.8
Heel T-Score 18.6 148.9 295.8 15.5 -8.1 -8.7 13.5 -17.2 8.2 -9.1 -11.6 13.6 12.7
BMI 1.4 8.5 29.6 0.5 -3.9 -1.2 -2.8 0.4 -4.9 -5.4 -0.2 -2.5 -0.8
Height 2.3 45.1 169.0 2.5 3.9 -3.5 8.4 -6.9 13.0 2.3 -3.8 6.5 8.2
Waist Hip Ratio (WHR) 0.7 3.2 11.5 -0.3 2.6 0.2 2.2 -1.1 0.8 3.4 0.9 1.8 1.8
Systolic Blood Pressure 6.3 32.2 72.2 -8.0 7.4 -3.5 -2.5 5.7 3.2 2.2 5.2 -8.5 -6.1
Smoking Status 2.4 5.8 17.5 1.2 1.3 -4.2 3.2 -2.8 3.2 -1.4 -0.6 1.1 2.4
Allergy or Eczema 0.3 0.8 6.0 -0.5 0.6 0.3 0.2 1.0 -0.5 -0.3 0.3 0.1 -2.4
Cardiovascular Disease 3.9 12.9 40.2 -3.7 0.8 -3.6 -2.6 3.8 -0.8 -2.7 1.3 -6.3 -5.5
Hypothyroidism (self reported) 0.5 1.3 4.7 -0.6 -0.0 -2.2 0.4 -1.1 -1.4 -1.4 -0.6 -1.0 1.1
Respiratory disease 1.2 2.6 7.1 -2.5 2.7 -0.1 -0.6 1.7 0.4 1.6 1.5 -1.8 -1.3
Type 2 Diabetes (T2D) 0.6 1.1 7.1 -0.2 -0.4 -0.0 -0.8 0.7 -2.7 -1.1 -0.2 -0.4 -1.1
Lung FEV1/FVC ratio 0.3 1.8 7.0 1.4 -1.6 2.6 -0.6 0.3 -1.3 0.4 -1.3 1.4 -0.7
Lung FVC 1.3 6.8 12.8 3.6 -1.4 -0.6 3.2 -3.3 3.2 -0.5 -1.8 3.5 2.5
Neuroticism 6.9 17.0 38.9 -6.2 5.6 0.6 -2.7 4.9 0.5 4.0 3.9 -4.9 -3.5
Chronotype (morning person) 1.3 3.1 12.2 0.7 -2.5 -2.7 -0.1 -0.3 0.1 -3.5 -1.3 -1.4 -1.1
Hair Pigment 0.4 13.9 37.8 3.7 1.0 0.4 5.1 -5.2 3.0 1.8 -2.0 6.2 4.1
Tanning 0.3 3.4 10.5 1.3 -0.4 -2.6 2.2 -1.1 3.2 -2.4 -1.6 0.8 -0.3
Hand grip strength (left) 2.0 5.3 24.5 -1.2 -0.4 2.7 -2.8 2.0 -4.9 0.0 1.7 -1.2 -1.9
Number of treatments/medications taken 2.4 4.3 11.2 2.7 -1.0 -0.9 2.8 -2.8 0.7 -1.5 -1.9 3.4 1.1
Average weekly spirits intake 0.5 0.6 2.7 -0.1 0.6 0.7 -0.1 0.8 -0.6 -0.4 1.2 0.3 -1.7
Sensitivity / hurt feelings 2.9 5.2 11.6 2.4 -0.1 -2.8 3.3 -3.4 1.2 -1.3 -0.9 2.5 2.4
Frequency of depressed mood in last 2 weeks 5.5 7.8 14.1 3.5 -3.8 -1.0 1.8 -3.1 0.1 -3.5 -3.5 2.9 2.0
Hearing difficulty/problems: Yes 0.9 1.4 5.1 0.8 -2.3 -1.6 -0.1 0.0 0.3 -1.9 -1.1 -0.3 -0.1
Relative age of first facial hair 0.7 1.6 3.3 -1.2 -0.4 0.5 -1.8 1.6 -1.8 0.1 1.1 -1.5 -1.1
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 6.5 -0.2 -0.2 1.0 -0.7 1.1 -2.2 -0.8 -0.9 0.4 -2.6
Ever used hormone-replacement therapy (HRT) 2.2 2.8 6.1 1.8 -0.5 -1.5 2.5 -2.0 2.1 -1.2 -1.4 2.1 0.4
Ever had hysterectomy (womb removed) 2.4 2.7 6.6 0.9 -0.9 -2.6 1.5 -1.5 2.5 -2.3 -1.4 0.3 1.1
Systolic blood pressure, automated reading 4.4 13.0 39.1 5.3 -4.3 2.7 2.4 -3.2 -1.6 -0.9 -3.5 6.2 2.4
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 4.7 -1.0 2.2 1.1 0.2 0.3 1.4 1.9 2.1 0.2 -0.2
Angina 2.5 3.2 9.2 1.4 -1.2 -1.0 1.5 -2.1 3.0 -0.8 -2.1 1.6 2.0
Medication for hormone replacement therapy 1.9 2.1 5.0 -0.8 -0.7 1.5 -1.4 2.0 -2.2 0.1 -1.0 -0.9 -2.2
Vitamin and mineral supplements 0.4 0.5 2.4 0.4 -0.7 -0.1 0.3 -0.8 0.7 -0.2 -0.7 0.6 1.6
Supplements: Zinc 1.7 1.8 3.8 -1.0 0.5 1.8 -1.4 1.6 -2.0 1.4 -0.3 -0.8 -1.7
Medication: Co-codamol 1.0 1.2 5.1 0.5 -1.6 0.5 0.1 -0.4 0.5 -1.6 -2.2 0.8 -0.4
Medication: Metformin 0.9 1.3 3.0 -1.2 1.4 1.2 -0.3 0.8 1.7 1.6 0.9 -0.1 -1.0
Diabetes (father) 0.8 1.0 1.8 0.2 1.3 -1.3 1.2 -0.8 1.3 0.3 1.1 0.6 0.9
Diabetes (mother) 0.5 0.7 2.1 0.7 -0.9 -1.4 0.3 -0.4 0.9 -1.0 -0.3 -0.6 1.0
Severe depression (siblings) 2.7 3.0 6.9 -2.0 1.1 0.1 -1.9 1.8 -2.6 0.8 2.1 -2.3 -0.7
Pack years adult smoking proportion 1.4 2.2 7.2 0.1 -1.1 2.7 -1.2 1.3 -1.8 1.3 -1.4 0.9 -1.4
Impedance of leg (right) 1.1 5.3 15.2 1.6 -3.9 -0.5 -0.6 -2.2 1.7 -2.7 -2.6 0.1 3.6
Leg fat-free mass (left) 1.7 9.4 23.0 -2.2 2.7 2.0 -1.8 3.8 -4.1 2.4 3.3 -1.6 -4.8
Trunk fat percentage 1.4 5.7 30.5 0.6 1.8 0.8 2.3 -1.0 5.5 2.8 -0.5 2.4 1.5
Hand grip strength (right) 1.0 2.8 13.6 -0.1 -1.0 2.2 -2.0 1.2 -3.7 -0.6 1.5 -0.3 -0.9
Townsend deprivation index at recruitment 1.4 2.0 7.8 1.2 -1.7 1.1 -0.3 -0.5 -2.8 -1.4 -1.4 1.5 -0.5
Current tobacco smoking 2.0 3.3 9.8 0.9 -3.1 2.8 -2.1 0.9 -2.7 -0.6 -0.8 0.2 -1.0
Average weekly fortified wine intake 0.5 0.6 2.1 0.7 -0.7 -0.6 0.5 -0.4 0.8 -0.5 -1.4 0.3 -0.8
Maternal smoking around birth 1.6 2.4 12.1 0.9 -0.8 3.5 -0.6 0.1 -0.9 1.9 -1.3 1.8 0.2
Fed-up feelings 10.3 19.0 41.4 6.4 -5.7 -1.3 3.6 -4.9 1.1 -4.2 -4.2 5.2 3.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.3 9.1 2.7 -3.0 -0.7 1.4 -1.9 -1.4 -2.9 -2.0 2.4 0.5
Relative age voice broke 1.1 1.7 3.3 -1.8 0.7 0.0 -1.5 1.8 -1.2 0.4 1.3 -1.8 -1.1
Taking other prescription medications 0.4 0.6 3.0 -0.1 -0.2 1.2 -0.6 1.0 0.1 -0.1 -0.5 0.4 -1.7
Age when periods started (menarche) 0.7 1.6 5.7 -0.2 -0.4 -1.9 -0.7 -1.0 -1.1 -2.4 1.0 -1.4 0.7
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 6.7 1.4 -1.7 -0.3 1.0 -1.4 0.6 -1.0 -2.6 1.6 0.9
Heel bone mineral density (BMD) T-score, automated (left) 13.5 30.6 60.2 -7.0 4.0 3.7 -5.8 7.8 -4.3 4.1 5.2 -6.0 -5.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 0.6 -0.5 -0.3 0.2 -0.5 0.0 -0.5 0.2 0.5 0.9
Qualifications: CSEs or equivalent 0.3 0.4 2.1 0.7 -0.4 -0.2 0.7 -0.4 0.3 -0.1 -1.4 0.6 0.7
Serious illness, injury or assault to yourself 0.2 0.2 1.1 -0.2 -0.2 -0.7 -0.1 0.1 0.4 -0.3 -1.0 -0.1 -0.1
High blood pressure 7.8 22.1 64.0 5.4 -1.7 2.0 4.5 -6.2 2.4 1.5 -2.8 8.0 6.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 4.2 0.4 -0.5 0.2 -0.1 -1.1 0.5 0.2 -0.7 0.4 2.0
Multivitamins +/- minerals 0.4 0.6 1.3 1.1 -1.2 -0.3 -0.0 -0.4 -0.9 -1.1 -0.3 0.3 -0.8
Stomach or abdominal pain in last month 0.7 0.8 1.7 -1.3 0.4 0.5 -1.2 1.2 -1.0 0.3 1.2 -0.9 -0.1
Supplements: Glucosamine 2.1 2.7 4.6 -2.0 1.2 0.0 -1.3 2.1 -1.4 1.1 1.8 -2.0 -2.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.9 -0.0 -1.1 -0.9 -0.5 0.7 0.8 -1.4 -0.0 -1.2 -0.2
Medication: Atenolol 1.2 1.4 6.1 -1.4 0.8 2.5 -1.1 0.4 -0.8 1.8 0.3 0.6 -0.1
Medication: Levothyroxine sodium 0.5 0.9 3.3 0.8 0.5 0.6 1.2 -0.3 1.8 0.5 0.2 1.7 -0.3
Sitting height 2.9 20.7 84.5 -2.2 -0.8 4.2 -5.4 5.3 -9.2 0.9 2.7 -3.3 -4.7
Chronic bronchitis/emphysema (father) 0.9 1.1 3.5 -0.1 -0.7 1.9 -1.1 0.9 -1.7 0.3 -0.5 0.4 -1.0
High blood pressure (mother) 2.4 3.4 7.5 2.5 -1.0 -0.9 2.3 -2.5 0.1 -0.4 -0.1 2.7 2.7
Body mass index (BMI) 1.2 5.2 18.0 -0.2 3.2 0.6 2.5 -0.3 4.2 3.4 0.4 2.3 0.3
Impedance of leg (left) 1.1 5.6 17.0 1.8 -4.1 -0.3 -0.7 -2.1 1.8 -2.5 -2.7 0.1 3.7
Leg predicted mass (left) 1.7 9.1 22.2 -2.2 2.8 1.9 -1.7 3.8 -3.9 2.4 3.4 -1.6 -4.7
Trunk fat mass 0.6 2.8 9.8 -0.2 2.0 1.3 1.1 0.3 3.1 3.0 0.6 1.4 -0.1
Waist circumference 0.5 1.9 10.4 0.5 1.2 -0.2 1.7 -0.3 3.2 1.0 -0.3 1.5 -0.6
Number of incorrect matches in round 3.0 5.0 11.9 -3.2 2.7 -1.0 -1.6 2.3 1.1 1.2 2.8 -3.4 -1.0
Past tobacco smoking 1.2 2.2 8.1 0.1 0.5 -2.9 1.1 -1.7 1.9 -1.3 0.4 -0.4 2.1
Alcohol usually taken with meals 2.0 3.2 10.6 0.8 -0.9 -3.2 0.8 -1.0 2.6 -2.4 0.6 -1.2 2.0
Nervous feelings 2.8 5.3 16.8 2.2 -1.1 -0.7 1.9 -3.8 0.9 -0.7 -1.9 2.6 4.1
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 6.4 1.9 -2.5 0.4 0.4 -1.8 -0.9 -1.6 -2.1 2.0 1.2
Hearing difficulty/problems with background noise 7.3 11.7 22.6 4.8 -3.8 -2.3 3.0 -4.0 1.5 -3.7 -3.6 3.8 2.4
Hair/balding pattern: Pattern 2 1.6 2.1 6.6 -1.0 0.0 1.7 -1.9 1.8 -2.6 0.3 0.7 -1.0 -1.5
Had menopause 0.4 0.5 1.7 -0.0 -1.3 0.7 -0.7 0.7 -0.6 -0.4 -0.4 -0.2 -1.1
Had other major operations 0.7 0.8 2.6 0.2 -1.2 -1.2 -0.8 -0.1 0.6 -1.6 0.2 -1.2 0.5
Forced vital capacity (FVC) 3.4 13.3 36.8 -3.1 -0.3 0.7 -4.6 4.3 -6.1 -1.5 2.0 -4.8 -4.1
Heel bone mineral density (BMD) T-score, automated (right) 15.2 34.9 64.1 -7.7 4.4 3.4 -6.3 8.0 -4.7 3.9 5.6 -6.6 -6.5
Ever unenthusiastic/disinterested for a whole week 2.6 3.3 6.9 -1.8 0.4 1.8 -2.5 2.3 -2.6 0.6 1.5 -1.5 -1.6
Qualifications: None of the above 0.6 1.3 3.8 1.0 -1.1 1.7 -0.2 -0.9 0.4 0.6 -0.5 1.7 2.0
Financial difficulties in last 2 years 0.6 0.8 2.7 0.8 -0.8 0.5 0.4 -0.5 -1.3 -0.7 -0.5 1.7 -0.7
Mouth/teeth dental problems 2.0 3.1 12.7 0.9 -1.1 -2.4 1.1 -0.3 -1.5 -3.6 -0.5 0.0 -2.6
Heart attack 0.4 0.5 2.2 0.8 -1.5 0.7 -0.5 0.2 -0.5 -1.0 -0.3 0.5 -0.1
Allergy 0.3 0.7 3.7 -0.8 1.0 -0.1 0.2 0.8 -0.4 0.2 0.5 -0.3 -1.9
Pain all over the body in last month 0.2 0.3 0.6 0.6 -0.6 0.8 0.1 0.4 -0.0 0.0 -0.6 0.7 -0.6
Diabetes (self-reported) 0.3 0.4 1.9 -0.2 0.7 0.2 0.7 -0.2 1.4 0.7 0.1 0.6 -0.5
Hayfever/allergic rhinitis (self-reported) 4.2 5.5 12.6 3.5 -2.7 -0.7 1.7 -2.5 2.2 -1.8 -2.9 2.2 1.9
Medication: Ramipril 1.0 1.3 4.3 0.5 0.4 1.4 0.6 -0.8 -0.9 1.8 -0.1 2.1 1.1
Medication: Simvastatin 1.1 1.6 5.2 1.9 -0.5 0.7 1.4 -1.3 1.3 -0.5 -0.7 2.3 0.4
Fluid intelligence score 2.1 4.3 13.7 1.0 -3.6 -1.1 -1.1 -0.5 -1.7 -3.7 -2.9 -1.2 -0.0
Illnesses of siblings 1.6 2.3 7.3 -0.3 -0.5 -2.7 -0.2 0.3 -0.8 -2.6 0.8 -2.2 -1.6
Neuroticism score 5.2 11.2 23.1 4.8 -4.8 -0.5 2.1 -4.0 -0.9 -3.5 -2.8 3.9 3.1
Weight 0.6 2.8 6.5 -1.1 1.9 1.6 -0.5 2.2 -0.7 2.3 1.8 -0.2 -2.5
Impedance of arm (right) 0.2 0.7 2.8 0.1 -0.3 0.8 -0.5 -0.9 1.7 0.3 -0.7 0.1 1.5
Arm fat percentage (right) 1.8 7.5 32.4 -0.1 3.2 0.8 2.6 -0.8 5.7 3.9 0.0 2.6 1.2
Trunk fat-free mass 3.1 18.3 57.3 -3.2 1.4 1.9 -4.1 5.2 -7.6 1.0 3.9 -3.7 -6.0
Hip circumference 0.8 3.7 10.4 1.1 1.6 -0.8 3.2 -1.4 3.2 1.5 -0.7 2.6 0.4
Time employed in main current job 2.0 2.3 6.9 -2.6 1.4 0.1 -2.0 1.7 -0.8 0.7 0.5 -2.4 -0.8
Alcohol intake versus 10 years previously 0.8 1.2 2.9 -1.5 1.7 0.5 -0.4 0.4 1.5 1.4 1.3 -0.7 0.2
Father’s age at death 1.5 2.0 5.4 0.7 0.3 -1.4 1.7 -2.1 2.3 -0.6 -1.1 1.0 1.4
Worrier / anxious feelings 0.4 0.7 3.5 0.7 -0.4 0.4 0.3 -1.2 -0.5 0.2 -0.6 1.0 1.9
Frequency of tiredness / lethargy in last 2 weeks 3.9 6.4 12.9 3.6 -3.0 -1.1 2.0 -3.2 -0.9 -3.0 -2.5 2.9 1.5
Falls in the last year 1.7 2.3 7.8 0.9 -1.8 1.9 -0.3 0.2 -2.8 -0.1 -1.9 1.6 -1.2
Hair/balding pattern: Pattern 3 2.3 3.4 7.4 0.8 1.2 -1.3 2.7 -2.4 2.4 0.9 -1.4 2.0 2.2
Number of live births 1.5 2.1 6.8 -1.4 0.8 2.6 -1.7 1.8 -0.7 2.1 1.0 -0.4 -0.3
Forced expiratory volume in 1-second (FEV1) 2.3 8.0 18.2 -2.8 0.5 -1.0 -3.2 2.9 -4.2 -1.9 2.3 -4.3 -2.7
Pulse rate 0.8 1.4 5.6 -0.4 -0.5 -0.7 -0.5 1.6 -1.0 -1.2 0.6 -1.5 -2.4
Happiness 1.8 2.2 5.4 2.3 -1.9 -0.2 1.3 -1.5 -0.2 -1.0 -1.8 2.1 -0.2
Noisy workplace 1.5 1.8 3.9 -0.8 0.2 1.9 -1.5 1.6 -1.5 1.3 2.0 -0.3 -0.9
Qualifications: A levels/AS levels or equivalent 1.7 3.7 16.3 1.3 -0.8 -4.0 1.9 -1.5 1.4 -3.2 -0.6 -0.5 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.3 0.3 0.5 -1.5 1.0 -1.3 0.4 -0.3 0.4 0.3 1.1
Mouth/teeth dental problems: Dentures 0.5 0.8 2.6 -0.7 -1.0 1.0 -1.6 1.3 0.2 -0.2 0.4 -1.1 -0.4
Asthma 1.7 3.4 7.1 2.7 -1.8 -0.7 1.6 -2.3 0.6 -1.5 -1.9 2.4 1.6
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 9.4 0.9 -2.0 -2.9 0.4 -1.0 1.0 -3.1 -0.9 -1.1 1.3
Medication: Cholesterol lowering 0.5 0.7 2.6 1.0 -0.4 1.5 0.3 -0.2 -0.1 0.5 -0.9 1.6 -0.1
Depression (self-reported) 1.2 1.5 4.6 1.1 -1.7 0.3 -0.1 0.1 -2.1 -1.4 -1.0 0.8 -1.5
Medication: Lansoprazole 0.8 0.9 2.5 0.8 0.1 -0.3 1.0 -1.1 1.6 -0.3 -1.6 1.0 0.6
Prospective memory result 2.4 3.0 13.8 -0.9 2.2 2.7 0.1 0.7 -1.0 3.7 0.2 1.2 -0.2
Lung cancer (father) 2.2 2.6 6.1 -1.6 -0.2 1.6 -2.4 1.9 -2.5 0.5 1.3 -1.5 -1.1
Illnesses of mother 1.1 1.3 4.9 -1.5 1.2 -0.3 -0.7 1.1 0.1 -0.1 -0.5 -1.6 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 3.2 10.3 25.0 -3.4 0.7 -0.8 -3.7 3.5 -4.7 -1.4 2.6 -5.0 -2.9
Pulse wave Arterial Stiffness index 0.6 0.7 2.3 1.5 -1.5 0.2 0.4 -0.7 -0.0 -0.7 -0.6 1.0 -0.2
Impedance of arm (left) 0.2 1.1 4.3 0.7 -0.8 0.7 -0.1 -1.0 2.1 0.0 -1.1 0.3 1.7
Arm fat mass (right) 0.9 3.8 12.1 -0.6 3.0 1.2 1.5 0.3 3.1 3.5 0.8 1.6 -0.3
Trunk predicted mass 3.1 18.0 56.1 -3.2 1.4 1.9 -4.0 5.2 -7.5 1.1 3.8 -3.7 -6.0
Standing height 2.9 29.4 110.2 -2.5 -2.2 2.8 -6.9 5.8 -10.5 -1.4 3.6 -5.6 -6.2
Length of working week for main job 0.9 1.0 3.3 -0.9 0.0 0.2 -0.9 1.8 -1.5 -0.1 0.4 -1.1 -1.4
Exposure to tobacco smoke at home 1.0 1.1 2.7 0.0 1.1 0.2 1.2 -0.8 1.1 1.6 -0.0 1.2 1.6
Breastfed as a baby 2.7 3.3 11.4 -1.0 -0.2 0.3 -1.7 2.3 -3.4 -0.3 1.8 -2.2 -2.0
Tense / ‘highly strung’ 1.0 1.7 7.2 1.1 -0.7 0.6 0.7 -1.8 0.5 0.3 -0.5 1.7 2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.3 14.0 2.3 -2.2 2.2 0.6 -1.3 -2.1 -0.6 -3.7 2.8 0.1
Hair/balding pattern: Pattern 4 2.4 6.1 13.5 3.7 -2.5 -0.5 3.1 -2.5 2.9 -1.4 -1.8 3.1 1.5
Birth weight of first child 1.3 2.4 8.0 -1.2 0.0 -2.4 -1.0 1.1 -0.4 -1.8 1.2 -2.8 -1.4
Peak expiratory flow (PEF) 1.1 2.5 9.7 -1.0 0.1 -0.7 -1.3 1.2 -3.1 -1.7 1.1 -2.0 -1.8
Pulse wave reflection index 0.5 0.7 1.9 0.9 -0.5 0.3 0.8 -1.0 1.0 0.2 -0.4 1.4 0.8
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.6 0.1 -1.6 0.4 -1.0 1.3 -1.6 -1.3 0.4 -0.5 -1.4
Loud music exposure frequency 1.1 1.2 3.1 -0.6 1.8 -0.5 0.5 0.0 1.6 1.4 1.5 0.0 1.3
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 5.2 1.7 -1.1 -2.3 1.4 -1.6 1.5 -1.8 -1.1 0.0 0.8
Mouth/teeth dental problems: Bleeding gums 5.0 6.4 26.4 -1.0 3.3 1.8 0.4 -1.1 2.0 5.1 1.0 1.1 3.9
Blood clot in the leg (DVT) 3.2 4.1 11.4 -1.4 -2.0 1.6 -3.4 2.9 -1.4 -0.6 -0.5 -3.1 -0.9
Medication: Paracetamol 0.7 1.2 6.0 0.6 -1.4 -1.7 0.1 -0.0 0.6 -2.4 -0.1 -0.7 0.1
Headache pain in last month 1.3 2.2 8.6 0.4 -1.6 -2.2 0.0 -1.2 1.2 -2.9 -0.4 -0.8 1.5
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 13.4 -2.3 0.8 -1.9 -1.5 1.7 0.1 -0.7 1.8 -3.7 -1.5
Glaucoma (self-reported) 2.3 2.8 6.9 -1.2 -1.2 -1.5 -1.8 1.3 -1.5 -2.5 1.0 -2.6 -1.2
Gout (self-reported) 0.4 0.5 1.9 0.9 -0.5 1.4 0.2 -0.3 -0.4 0.6 0.3 1.4 0.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 3.6 1.1 -0.0 1.3 0.8 -0.2 1.8 0.7 -0.3 1.9 0.2
Medication: Amlodipine 3.5 5.0 18.1 2.4 -0.8 2.9 1.6 -2.2 -0.2 1.8 -1.9 4.3 1.6
Medication: Ventolin 100micrograms inhaler 0.9 1.1 4.3 1.3 -2.1 0.5 -0.1 -0.4 -0.1 -1.1 -1.6 0.9 0.4
Birth weight 1.4 3.1 11.5 -0.7 -0.9 -0.2 -1.7 1.5 -3.4 -1.6 1.7 -1.7 -2.2
Chronic bronchitis/emphysema (mother) 1.5 1.8 7.0 -0.3 -1.1 2.6 -1.9 1.4 -1.3 1.2 0.3 -0.3 -0.7
High blood pressure (siblings) 1.4 2.1 6.7 0.8 0.1 2.0 0.3 -0.8 0.7 1.9 0.1 2.1 2.6
Forced vital capacity (FVC), Best measure 4.6 17.4 45.7 -4.1 0.3 0.8 -5.3 4.8 -6.8 -0.8 3.1 -5.7 -4.1
Body fat percentage 1.7 7.0 35.8 0.8 1.8 0.9 2.6 -1.3 6.0 3.0 -0.7 2.8 1.9
Leg fat percentage (right) 2.1 7.9 38.2 1.0 1.4 0.4 3.0 -2.0 6.2 2.5 -1.2 3.1 2.7
Arm fat-free mass (right) 1.6 8.3 26.7 -1.6 0.3 1.5 -2.7 3.8 -5.2 0.6 2.4 -2.3 -4.3
Exposure to tobacco smoke outside home 1.7 2.3 6.2 1.3 -0.1 -0.9 1.7 -1.8 1.5 0.8 -1.7 1.5 2.5
Comparative body size at age 10 1.1 3.0 12.0 -0.5 2.4 1.6 1.1 1.5 1.6 3.5 1.2 1.1 -1.1
Number of full brothers 0.8 1.1 3.2 -0.0 0.3 1.8 -0.4 0.7 -1.8 1.5 0.6 0.8 -0.4
Worry too long after embarrassment 0.3 0.5 1.6 0.9 -0.6 0.8 0.2 -0.8 -1.3 0.0 -0.2 1.1 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.5 -0.1 -0.5 1.0 -0.6 0.5 -1.9 -0.3 -1.1 0.4 -1.6
Wheeze or whistling in the chest in last year 0.7 1.2 5.2 1.0 -1.8 2.3 -1.0 0.3 0.2 0.6 -0.4 1.1 0.4
Number of children fathered 2.6 3.0 6.7 -2.5 1.9 1.3 -1.4 1.7 -0.0 2.6 1.8 -1.7 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 3.8 -0.1 0.5 2.0 0.2 0.4 -1.0 1.2 0.4 1.0 -1.4
Age at first live birth 1.8 3.3 13.4 1.4 -1.5 -2.8 1.4 -1.3 0.9 -3.7 -1.4 0.3 -0.9
Pulse wave peak to peak time 0.7 0.8 2.3 -1.5 1.3 -0.0 -0.8 0.9 -0.6 0.6 0.7 -1.3 -0.1
Health satisfaction 0.7 0.9 2.5 1.3 -1.6 0.8 0.1 -0.7 -1.1 -0.5 -0.1 1.2 0.9
Shortness of breath walking on level ground 2.6 3.1 7.7 2.4 -2.3 0.3 1.2 -1.7 0.7 -1.1 -2.8 2.1 1.2
Qualifications: College or University degree 0.5 1.6 6.2 1.0 -0.9 -1.7 1.1 -0.2 -0.1 -2.5 -1.5 0.3 -1.2
Eye problems/disorders: None of the above 0.7 0.8 2.4 0.9 -0.8 -1.0 0.7 -1.0 0.2 -0.9 -0.7 0.1 1.6
Mouth/teeth dental problems: Loose teeth 1.1 1.3 5.3 0.6 -0.7 2.3 -0.5 0.3 0.0 1.4 -1.7 1.1 0.5
Emphysema/chronic bronchitis 0.4 0.4 1.8 0.4 -0.6 0.8 -0.7 0.2 -1.3 0.7 0.5 0.2 0.1
Medication for pain relief, constipation, heartburn 0.7 1.3 3.1 -0.8 0.6 1.5 -0.9 1.1 -1.8 1.1 0.5 -0.4 -1.7
Neck or shoulder pain in last month 1.3 1.8 7.7 1.5 -2.8 -0.5 0.1 -0.6 -0.3 -2.5 -1.0 0.5 0.1
Medication: Blood pressure 3.7 6.5 24.6 3.0 -1.2 2.0 2.3 -2.8 0.0 0.7 -2.2 5.0 2.8
Angina (self-reported) 2.0 2.6 8.6 1.1 -1.1 -0.9 1.3 -1.8 2.9 -0.8 -1.9 1.3 1.8
Migraine (self-reported) 2.8 3.5 12.2 0.1 -2.4 -1.6 -1.4 0.8 -2.5 -3.5 -0.1 -2.0 -1.6
Medication: Ibuprofen 1.7 2.1 8.0 0.5 -1.2 -2.8 0.9 -1.2 0.9 -2.4 -0.5 -0.8 1.3
Medication: Allopurinol 0.7 1.0 4.0 1.3 -0.4 0.7 1.0 -0.8 -0.6 0.3 -0.9 2.0 0.5
Medication: Omeprazole 0.5 0.6 1.3 -1.1 1.2 -0.4 -0.1 0.7 0.6 -0.1 1.0 -0.4 -1.1
Medication: Seretide 50 evohaler 0.7 0.8 2.2 -0.3 -0.4 1.4 -0.9 0.7 -1.5 0.8 0.4 0.4 -1.0
Mean time to correctly identify matches 11.2 21.6 35.6 -5.6 4.4 5.2 -4.7 5.2 -3.6 6.0 4.3 -3.4 -3.2
Heart disease (mother) 0.8 1.0 3.3 -0.3 1.1 1.6 -0.6 0.1 -0.1 1.8 1.1 0.6 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 3.4 1.4 -1.9 0.2 0.6 -1.1 1.8 -0.8 -1.8 1.7 1.0
Whole body fat mass 0.7 3.1 10.8 -0.1 2.1 1.3 1.3 0.2 3.3 3.0 0.6 1.6 0.1
Leg fat mass (right) 0.7 2.8 10.8 0.0 1.8 1.1 1.5 0.0 3.3 2.7 0.2 1.8 0.2
Arm predicted mass (right) 1.7 8.7 26.2 -1.7 0.4 1.5 -2.8 4.0 -5.1 0.6 2.6 -2.5 -4.4
Pulse rate, automated reading 1.0 3.3 17.5 -0.8 -0.7 -1.1 -0.5 2.1 -0.9 -2.0 0.0 -1.8 -4.2
Alcohol intake frequency. 0.9 2.2 9.1 -1.1 0.4 -2.0 -0.4 1.1 3.0 -0.7 1.4 -1.9 0.0
Comparative height size at age 10 3.5 19.6 50.5 -2.9 -1.2 2.9 -5.9 5.6 -7.1 0.2 3.3 -4.6 -5.4
Number of full sisters 0.7 0.8 1.9 -0.8 0.7 1.2 -0.8 0.7 -1.0 1.2 1.4 -0.4 0.2
Suffer from ‘nerves’ 5.1 8.1 17.1 3.7 -4.1 -0.8 1.3 -3.2 -1.4 -3.7 -3.6 2.4 1.7
Overall health rating 2.3 4.9 12.4 3.1 -3.5 1.5 0.8 -1.2 -1.0 -2.0 -2.7 3.3 -0.0
Chest pain or discomfort 1.5 2.2 12.6 1.0 -3.5 1.2 -1.4 -0.0 -1.1 -1.2 -1.1 0.2 0.7
Had major operations 2.4 2.8 6.9 2.2 -2.0 -1.2 1.2 -1.8 0.1 -1.8 -2.6 1.4 0.9
Age at last live birth 0.5 0.8 4.1 0.4 -1.0 -0.8 -0.0 0.1 -0.7 -2.0 -0.2 -0.4 -1.2
Family relationship satisfaction 0.6 0.7 2.8 0.7 -1.0 1.2 -0.8 0.5 -1.7 0.4 0.4 0.2 -0.1
Leg pain on walking 1.1 1.4 4.6 1.1 -2.1 1.0 -0.8 -0.2 -1.1 -1.4 -1.4 1.0 0.5
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.6 10.2 -3.2 2.4 -0.0 -1.3 1.8 -0.2 1.4 2.3 -2.5 -1.0
Commuting to job workplace: Car/motor vehicle 2.7 3.1 8.2 -2.8 1.6 -0.1 -1.9 2.0 -0.3 1.2 1.5 -2.9 -1.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 2.4 -0.1 0.5 0.4 -0.1 0.2 1.5 0.4 0.2 -0.3 -0.2
Medication: Aspirin 0.8 1.0 4.0 1.1 -0.8 1.5 0.3 -0.4 0.2 0.8 -1.1 2.0 0.0
Supplements: Vitamin C 1.0 1.2 3.4 -1.7 1.0 -0.3 -1.3 1.1 0.3 0.8 0.6 -1.8 -0.6
Knee pain experienced in last month 0.9 1.4 3.2 -1.4 -0.5 -1.0 -1.3 0.8 -1.6 -0.6 0.4 -1.8 -1.2
Hypertension (Self-reported) 7.4 20.8 62.7 5.0 -1.5 2.5 4.2 -5.7 2.3 2.2 -2.8 7.9 6.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.4 -0.7 -0.0 -0.8 -1.0 0.1 -0.8 -0.5 1.4 -1.5 0.3
Illnesses of father: Heart disease 0.8 1.2 3.6 1.7 -0.8 0.3 1.2 -1.1 -0.5 -0.3 -1.1 1.9 0.4
Illnesses of siblings: Diabetes 0.6 0.8 2.2 -0.3 1.4 -0.2 0.8 -0.2 1.5 1.5 0.3 0.5 0.5
Smoking status: Previous 0.8 1.2 2.8 -1.0 1.1 1.4 -0.4 1.4 -0.8 1.7 0.2 -0.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 3.8 7.9 20.7 -2.3 0.6 0.3 -3.1 3.2 -4.5 -0.6 2.6 -3.5 -3.8
Whole body fat-free mass 2.4 13.9 38.2 -2.8 1.9 1.9 -3.1 4.7 -6.2 1.6 3.7 -2.9 -5.5
Leg fat-free mass (right) 1.8 9.8 24.1 -2.2 2.7 1.9 -1.8 4.0 -4.3 2.3 3.4 -1.8 -4.9
Arm fat percentage (left) 2.0 8.3 37.0 0.3 3.1 0.7 3.1 -1.1 6.1 3.8 -0.2 2.9 1.4
Average weekly red wine intake 0.1 0.2 0.6 -0.1 0.6 -0.5 0.7 -0.1 -0.6 -0.3 0.5 -0.0 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 0.0 0.5 0.5 0.5 -0.7 -0.9 0.8 -0.8 0.5 0.4
Mood swings 4.8 8.9 17.8 3.8 -3.2 0.2 2.1 -4.1 -0.0 -1.7 -2.6 4.0 4.2
Loneliness, isolation 4.7 6.5 16.9 3.6 -4.1 0.2 0.7 -2.5 -2.1 -3.1 -2.6 2.4 1.5
Long-standing illness, disability or infirmity 1.2 1.9 5.2 -0.1 -1.0 2.2 -1.3 1.2 -1.8 0.3 -1.0 0.5 -2.3
Ever had bowel cancer screening 0.6 0.7 1.7 -1.1 1.1 -0.4 -0.3 0.8 1.2 0.7 0.1 -1.3 -0.2
Diabetes diagnosed by doctor 0.3 0.5 1.7 -0.6 0.5 0.4 -0.0 0.6 1.1 0.5 0.5 -0.1 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.9 -0.6 0.7 -0.1 -0.7 0.3 0.4 0.0 1.7 -1.0 0.6
Friendships satisfaction 1.5 1.9 5.8 1.3 -2.4 1.2 -0.8 0.6 -1.8 -1.4 -1.3 0.6 -1.4
Qualifications: nursing, teaching 0.8 1.2 3.8 1.6 0.1 -0.0 1.8 -1.1 -0.0 -0.3 -0.4 1.9 -0.8
Commuting to job workplace: Walk 2.4 2.6 5.8 2.4 -2.3 -0.4 0.9 -1.6 -0.1 -2.0 -2.0 1.6 1.1
Eye problems/disorders: Cataract 0.6 0.7 4.1 0.1 -0.0 1.2 -0.1 1.0 0.3 0.6 -0.3 0.4 -2.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.4 -0.9 1.4 0.9 -0.5 0.7 -0.8 2.1 0.2 -0.0 0.3
Medication for cholesterol 1.6 2.4 7.6 -1.3 -0.3 -1.5 -1.4 1.5 -0.5 -1.7 0.7 -2.8 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 9.8 -1.8 3.1 1.1 -0.2 0.9 0.1 3.1 1.2 -0.2 0.1
Back pain experienced in last month 2.8 4.1 12.8 2.0 -2.8 -2.2 1.2 -2.2 0.5 -3.6 -1.6 1.1 1.1
Mineral and other dietary supplements 0.2 0.3 0.7 -0.0 -0.9 0.9 -0.6 0.4 -0.6 -0.3 -0.2 -0.1 -0.1
Breast cancer (self-reported) 0.3 0.4 1.2 -0.9 1.1 0.3 -0.4 0.4 0.2 0.6 0.9 -0.2 -0.4
Asthma (self-reported) 1.5 3.0 6.5 2.5 -1.9 -0.5 1.4 -2.1 0.4 -1.4 -1.9 2.3 1.4
Osteoporosis (self-reported) 3.9 4.8 9.5 2.7 -2.0 -1.9 1.9 -2.4 1.2 -3.1 -2.8 1.7 1.3
Osteoarthritis (self-reported) 0.6 0.7 2.1 0.9 -1.0 -0.6 0.4 -0.5 -1.4 -1.4 -0.3 0.7 -0.3
Medication: Aspirin 0.5 0.7 2.7 0.5 -0.1 1.6 0.1 -0.1 -0.2 1.2 -0.4 1.6 -0.3
Medication: Gliclazide 0.8 0.9 2.7 -0.7 0.6 1.6 -0.4 1.0 0.6 1.7 -0.4 0.1 -1.2
Illnesses of father: None of the above (group 1) 1.8 2.2 8.6 -2.0 0.8 -0.6 -1.6 1.8 0.2 0.6 1.3 -2.9 -0.4
Smoking status: Current 2.0 3.2 10.3 0.9 -3.2 2.8 -2.1 0.9 -2.5 -0.4 -0.9 0.1 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.7 8.3 -2.9 2.1 -0.7 -1.4 1.1 0.2 1.2 1.5 -2.5 0.4
Whole body water mass 2.4 13.9 38.3 -2.7 1.8 1.8 -3.2 4.7 -6.2 1.4 3.7 -2.9 -5.5
Leg predicted mass (right) 1.8 10.0 24.0 -2.3 2.7 1.9 -1.9 4.0 -4.3 2.4 3.5 -1.8 -4.9
Arm fat mass (left) 0.8 3.5 11.1 -0.6 2.8 1.1 1.4 0.5 3.1 3.3 0.8 1.4 -0.6
Number of self-reported non-cancer illnesses 4.0 6.9 16.1 4.0 -3.7 0.5 1.4 -2.6 -0.5 -2.6 -3.1 3.6 1.1
Average weekly champagne plus white wine intake 0.6 0.8 2.9 -0.8 -0.5 -0.1 -1.2 0.2 0.4 0.7 -0.2 -1.4 1.7
Miserableness 8.9 15.7 31.2 5.6 -4.4 -0.8 3.2 -5.5 1.1 -3.0 -3.0 5.0 4.6
Guilty feelings 3.0 4.5 11.1 2.5 -3.3 2.2 0.3 -1.5 -2.3 -0.6 -2.2 3.0 0.9
Wears glasses or contact lenses 0.4 0.4 1.3 -0.5 0.4 0.8 0.0 0.4 -0.8 0.9 1.1 0.4 -0.6
Ever taken oral contraceptive pill 1.9 2.1 7.8 0.4 -0.8 -2.8 0.6 -0.5 -1.5 -2.8 -0.1 -0.9 -1.0
Hearing aid user 0.8 0.9 2.9 -0.2 0.7 0.6 0.7 -0.3 1.7 1.7 -0.6 1.0 0.4
Mother’s age at death 0.9 1.2 4.0 0.1 0.3 -2.0 1.2 -1.4 1.1 -0.8 -0.5 0.2 1.5
Financial situation satisfaction 0.3 0.4 1.5 0.6 -0.7 -0.0 -0.3 0.3 -1.2 -0.9 -0.1 0.0 -0.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.2 -0.2 -0.1 0.8 -0.6 -0.1 0.6 0.4 1.1 -0.1 0.9
Commuting to job workplace: Public transport 0.7 0.8 1.9 1.3 -0.5 0.1 0.9 -0.9 -0.6 -1.0 -0.8 1.4 0.5
Eye problems/disorders: Glaucoma 3.1 3.7 8.5 -1.0 -1.8 -0.8 -2.3 1.8 -1.9 -2.7 0.4 -2.9 -1.9
Medication: Blood pressure 3.9 7.6 22.1 2.3 0.3 1.3 2.4 -3.5 2.1 2.6 -0.7 4.1 4.7
Pain type(s) experienced in last month: Hip pain 0.7 0.8 2.9 1.0 -1.4 0.2 0.4 -0.4 -0.8 -1.7 -0.0 0.9 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 5.0 -1.3 2.2 -0.5 0.5 0.4 0.0 1.6 1.1 -0.4 -1.0
High cholesterol (Self-reported) 1.2 2.1 6.6 2.1 -0.8 1.8 0.9 -1.3 0.8 0.5 -1.1 2.6 1.2
Medication: Bendroflumethiazide 3.8 5.8 18.1 2.7 -0.9 1.2 2.0 -3.3 1.1 0.9 -0.5 3.6 4.3
Medication: Paracetamol 0.5 0.8 3.6 0.2 -1.1 -1.4 -0.1 0.5 0.3 -1.9 -0.1 -1.1 -0.4
Medication: Lisinopril 4.2 5.5 13.5 2.7 -1.5 0.6 1.9 -3.0 1.8 -0.0 -2.3 3.3 3.7
Medication: Atorvastatin 0.5 0.6 1.5 -0.4 1.1 1.2 0.2 0.4 -0.4 1.1 0.3 1.0 -0.5
Illnesses of father: High blood pressure 1.2 1.5 4.8 0.6 -0.4 2.2 -0.5 -0.8 -0.9 1.4 -0.2 1.6 1.9
Alcohol drinker status: Never 1.1 1.3 9.1 0.1 -0.3 -0.8 0.7 -0.5 3.0 0.0 -0.8 -0.2 1.2
Ever smoked 0.9 1.7 5.9 0.5 -1.2 2.4 -1.2 1.3 -1.9 0.6 -0.4 0.2 -1.4
Basal metabolic rate 1.8 10.2 23.4 -2.4 2.0 1.8 -2.5 4.1 -4.8 1.8 3.3 -2.3 -4.8
Leg fat percentage (left) 2.1 7.7 37.8 0.8 1.6 0.6 2.8 -1.7 6.1 2.9 -1.1 3.1 2.4
Arm fat-free mass (left) 1.6 8.1 24.7 -1.8 0.9 1.4 -2.5 3.6 -5.0 0.8 2.6 -2.2 -4.4
Number of operations (self-reported) 0.5 0.7 1.8 -0.0 -0.5 -1.3 -0.5 0.1 0.9 -0.9 -1.3 -1.1 -0.4
Average weekly beer plus cider intake 2.8 4.1 10.9 -1.6 -0.2 3.2 -2.5 2.2 -3.3 1.7 -0.1 -0.8 -1.5
Irritability 0.6 0.9 2.3 1.0 -1.5 -0.6 0.4 -1.0 -0.2 -1.5 -0.8 0.7 1.2
Risk taking 2.2 3.2 10.7 -1.5 0.8 1.6 -1.6 2.1 -3.3 0.7 0.8 -0.9 -2.7
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.6 1.8 -1.2 -0.5 1.5 -1.3 0.3 -0.8 -1.9 1.5 -0.6
Fractured/broken bones in last 5 years 1.6 2.1 5.9 1.6 -1.1 -0.8 0.9 -2.0 -0.9 -1.2 -2.4 1.5 1.0
Age started oral contraceptive pill 0.7 0.8 2.1 1.1 -0.0 -0.9 0.8 -1.3 1.4 -0.2 0.1 0.4 1.5
Diastolic blood pressure, automated reading 2.2 6.9 22.6 3.5 -2.7 2.4 1.5 -2.4 -0.1 0.2 -2.0 4.7 3.0
Ever depressed for a whole week 0.7 0.9 3.6 -0.6 0.5 1.2 -0.8 0.9 -1.9 0.3 0.1 -0.3 -1.0
Unable to work because of sickness or disability 1.6 2.1 10.2 0.3 -1.2 1.9 -0.8 0.9 -3.2 0.3 -0.4 0.8 -1.8
Commuting to job workplace: Cycle 0.5 0.6 1.7 0.0 1.3 -0.1 1.2 -0.5 0.5 0.3 1.0 0.8 -0.5
Myopia 2.2 3.2 9.3 -1.0 -1.4 2.0 -2.4 1.9 -3.0 0.5 -0.6 -1.7 -1.8
Vascular/heart problems diagnosed by doctor 7.0 19.4 57.2 -5.2 2.0 -2.2 -4.0 5.6 -2.2 -1.4 2.9 -7.6 -6.3
Cholesterol lowering medication 1.8 2.6 7.4 1.8 -0.1 -0.0 1.7 -2.0 2.7 -0.2 0.1 2.1 2.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.5 -1.1 0.9 -0.7 -0.0 0.5 1.2 -0.1 0.2 -0.5 -0.6
Pain experienced in last month 2.3 3.8 8.6 -1.9 2.4 2.4 -1.3 2.3 -1.6 2.9 1.5 -0.7 -1.5
Supplements: Calcium 1.0 1.1 3.9 1.1 -1.1 -0.6 0.2 -0.4 -0.9 -1.6 -2.0 0.3 -1.1
Basal cell carcinoma (self-reported) 1.1 1.3 4.7 1.2 0.5 1.0 1.2 -1.2 0.2 1.3 -1.0 2.2 0.2
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.4 0.8 -1.8 1.1 -0.9 0.5 -0.9 -1.0 -0.5 0.5 -0.4
Deep venous thrombosis (DVT) (self-reported) 3.4 4.3 12.5 -1.7 -1.5 1.8 -3.5 3.0 -1.5 -0.1 -0.2 -3.1 -1.1
Heart disease (siblings) 1.0 1.2 2.4 -1.3 0.6 1.5 -1.5 1.4 -0.6 1.2 0.4 -0.8 -0.9
Alcohol drinker status: Previous 1.0 1.2 3.2 1.5 -1.2 1.1 0.4 -0.4 0.3 -0.6 -1.8 1.6 -0.2
Pack years of smoking 1.8 2.6 9.0 0.1 -1.2 3.0 -1.3 1.5 -1.9 1.5 -1.5 0.9 -1.7
Impedance of whole body 0.8 4.0 11.4 1.7 -2.8 -0.1 -0.1 -2.1 2.6 -1.7 -2.0 0.4 3.4
Leg fat mass (left) 0.7 2.9 9.5 -0.3 2.0 1.5 1.2 0.5 3.1 3.1 0.3 1.5 -0.1
Arm predicted mass (left) 1.4 7.3 21.9 -1.7 0.8 1.3 -2.4 3.5 -4.7 0.7 2.5 -2.1 -4.1