Hub : Genes

MAP1LC3B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.19 0.059 8.7e-05 0.013 NA 0.027 NA 0.018 2.9e-02 NA 3.0e-03 NA 1.3e-02
2 METSIM Adipose 0.09 0.026 2.6e-06 0.071 0.031 0.060 0.055 0.056 7.1e-11 1.9e-05 2.1e-09 1.0e-08 8.5e-09
3 NTR Blood 0.05 0.015 4.4e-05 0.015 0.017 0.029 0.031 0.032 8.7e-06 2.9e-06 9.8e-10 2.1e-10 1.6e-10
4 YFS Blood 0.15 0.022 0.0e+00 0.076 0.114 0.102 0.100 0.098 9.2e-24 4.0e-35 1.1e-31 4.2e-31 2.6e-30
5 TCGA Breast Normal 0.11 0.038 4.3e-04 -0.001 0.016 0.015 0.026 -0.001 9.9e-01 2.3e-05 6.0e-05 9.5e-08 9.9e-01
6 TCGA Ovarian Tumor 0.12 0.050 8.6e-03 0.000 0.019 0.022 NA 0.003 2.9e-01 5.1e-03 2.5e-03 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Alzheimer’s Disease (in mother) 0.7 0.8 1.8 -0.8 -0.8 -0.1 -1.3 1.3 0.3
Alzheimer’s Disease (in father) 1.7 1.8 2.9 1.7 1.1 1.7 1.7 0.9 0.6
Alzheimer’s Disease (including proxy) 0.6 0.8 2.9 -0.1 -0.7 0.6 -0.0 1.7 1.0
Crohns Disease (2017) 0.7 1.6 7.7 0.4 0.3 -1.2 -0.5 0.3 2.8
Irritable Bowel Disease (IBD) 0.4 1.0 4.0 -0.5 0.2 -1.1 -0.4 0.5 2.0
Ulcerative Colitis (UC) 0.2 0.3 0.9 -0.2 1.0 -0.3 0.2 0.5 0.6
Major Depression (MDD) 0.5 0.6 1.5 -1.2 -0.7 -0.4 0.5 -1.0 -0.2
Reaction Time 5.0 9.7 16.6 -4.0 -4.1 -3.2 -3.8 -0.1 -1.0
Verbal and Numeric Reasoning (VNR) 4.0 9.8 19.1 3.1 4.1 4.4 2.8 -1.9 1.1
Breast Cancer 1.0 2.4 4.9 -0.6 -1.9 -0.8 0.3 2.1 -2.2
Ovarian Cancer 1.3 1.8 5.4 0.1 1.1 1.2 2.3 1.2 -1.0
Prostate Cancer 0.2 0.3 1.4 0.1 0.7 0.3 1.2 -0.0 -0.2
Age at First Birth 0.7 1.0 2.1 1.3 -0.5 -1.5 0.5 0.4 1.3
Bipolar Disorder 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 -0.5 0.1 -0.1 -0.1 0.3 -0.5
Coronary Artery Disease (CAD) 0.5 0.6 1.3 -1.1 -1.1 0.0 0.1 0.6 -0.7
Crohns Disease (2012) 0.5 0.8 1.9 -0.5 -1.4 -0.0 0.1 1.0 -1.4
Mean Putamen Volume 1.4 1.6 7.0 0.9 0.1 -0.2 1.1 -2.6 -0.7
Fasting Glucose 0.2 0.2 0.8 -0.5 0.9 -0.2 0.1 0.6 -0.1
HbA1C 1.3 1.4 7.6 -0.4 -0.2 -0.5 -0.4 -2.8 -0.6
HDL Cholesterol 1.5 2.4 6.5 -1.0 -1.6 -1.6 -2.5 -1.0 -0.9
LDL Cholesterol 1.0 1.6 4.4 0.8 1.1 1.4 0.8 -0.5 2.1
Lupus 0.4 0.5 1.8 -0.7 -1.3 -0.7 0.2 0.1 -0.6
Neuroticism 2.0 2.9 5.6 -2.0 -2.4 -2.1 -1.6 -0.7 -0.3
Primary Biliary Cirrhosis 0.9 1.3 3.6 -0.8 -0.8 0.0 -1.6 -1.9 0.4
Rheumatoid Arthritis 0.6 0.8 1.7 -1.3 -0.6 -1.3 -0.7 0.5 0.8
Schizophrenia 1.8 4.0 9.9 -2.2 -2.4 -3.1 -1.6 0.6 -0.6
Triglycerides 0.7 1.2 5.9 -0.6 0.0 0.1 0.9 -0.2 2.4
Type 2 Diabetes (T2D) 1.1 1.3 2.7 1.6 1.0 1.0 1.4 0.1 1.1
Ulcerative Colitis 0.2 0.3 0.5 -0.3 -0.7 0.5 -0.4 0.6 -0.6
Blood Eosinophil Count 0.3 2.3 4.5 -0.9 -1.1 -2.1 -1.6 -0.3 -2.1
Blood Platelet Count 0.3 3.5 9.0 -3.0 -2.1 -2.0 -1.1 -1.5 0.6
Blood Red Count 0.1 1.1 2.2 -1.5 -0.5 -0.2 0.7 -1.3 -1.2
Blood White Count 0.6 4.1 16.1 -4.0 -1.2 -1.6 -1.9 -1.1 -0.4
Heel T-Score 0.7 5.5 10.9 -2.0 -2.0 -2.0 -1.9 2.5 -3.3
BMI 0.3 1.9 7.4 -1.1 1.1 1.1 0.0 -0.7 -2.7
Height 0.3 5.3 14.7 3.8 3.0 2.0 0.8 -0.6 1.9
Waist Hip Ratio (WHR) 0.3 1.6 4.1 -0.7 -2.0 -1.4 -0.8 -0.1 1.5
Systolic Blood Pressure 0.4 1.9 4.7 -1.5 -0.2 2.0 2.2 0.3 -0.2
Smoking Status 4.5 10.8 22.2 -3.5 -4.7 -4.3 -3.1 0.8 0.9
Allergy or Eczema 0.3 0.9 2.7 -1.1 -0.0 0.3 0.7 1.6 1.0
Cardiovascular Disease 0.5 1.8 4.6 -0.5 1.5 2.1 1.4 0.1 -1.3
Hypothyroidism (self reported) 0.6 1.4 3.6 -1.3 -0.1 -1.2 -0.6 1.9 1.0
Respiratory disease 0.3 0.6 1.8 -1.2 -0.2 -0.3 -0.1 1.3 0.2
Type 2 Diabetes (T2D) 0.4 0.7 1.5 -1.1 0.7 -0.7 -0.3 0.8 -1.2
Lung FEV1/FVC ratio 0.7 3.5 6.8 1.2 2.6 2.2 2.1 -1.9 0.3
Lung FVC 0.2 0.8 3.6 1.9 0.2 -0.3 0.7 -0.2 0.9
Neuroticism 7.1 17.4 31.1 -4.9 -5.2 -5.6 -4.6 -0.3 0.5
Chronotype (morning person) 0.2 0.4 1.2 -0.5 -0.1 -1.0 -0.0 -1.1 -0.4
Hair Pigment 0.6 19.3 43.7 3.5 5.0 5.1 6.6 -1.8 2.5
Tanning 0.8 10.9 23.0 -1.7 -4.8 -4.6 -3.1 2.9 -0.7
Hand grip strength (left) 0.8 2.1 4.7 -0.0 1.5 2.2 1.7 1.0 -1.4
Number of treatments/medications taken 0.3 0.6 2.4 1.6 -0.1 -0.1 0.6 -0.7 0.5
Average weekly spirits intake 0.4 0.5 1.0 1.0 0.7 -0.1 -0.4 -1.0 0.3
Sensitivity / hurt feelings 3.9 6.9 13.9 2.4 3.7 3.7 2.8 0.2 -0.0
Frequency of depressed mood in last 2 weeks 2.1 3.0 7.8 2.8 1.6 1.8 1.4 1.0 -1.1
Hearing difficulty/problems: Yes 0.8 1.2 1.9 -0.8 -1.2 0.2 1.2 1.3 -1.4
Relative age of first facial hair 2.1 4.4 9.8 -1.8 -3.1 -3.0 -1.5 -0.4 -1.4
Other serious medical condition/disability diagnosed by doctor 2.1 2.7 7.8 -0.3 -0.6 -1.7 -1.9 -2.8 -1.1
Ever used hormone-replacement therapy (HRT) 0.9 1.1 4.0 2.0 1.1 -0.2 0.5 -0.5 0.9
Ever had hysterectomy (womb removed) 1.8 2.0 5.2 -0.7 -1.0 -2.0 -2.3 0.6 -1.2
Systolic blood pressure, automated reading 0.4 1.0 2.9 0.6 -0.3 -1.7 -1.1 0.9 -0.9
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.4 1.5 1.2 1.6 0.6 -0.4 0.3
Angina 0.1 0.2 0.7 -0.8 0.3 0.1 -0.1 0.4 -0.2
Medication for hormone replacement therapy 1.8 2.0 3.9 1.6 2.0 1.7 1.3 -0.7 0.5
Vitamin and mineral supplements 0.4 0.5 1.6 0.3 -0.1 -0.8 0.6 -0.7 1.2
Supplements: Zinc 1.5 1.6 3.2 1.0 0.6 1.7 1.0 -1.8 -1.1
Medication: Co-codamol 0.5 0.5 1.6 -0.5 -0.8 -1.3 -0.3 -0.8 -0.2
Medication: Metformin 0.3 0.4 1.5 1.2 0.2 -0.3 0.5 -0.7 0.5
Diabetes (father) 1.8 2.3 6.5 -0.4 -1.4 -2.6 -0.6 -1.5 -1.6
Diabetes (mother) 0.5 0.7 2.1 0.8 0.2 0.9 1.4 0.3 0.6
Severe depression (siblings) 1.3 1.5 3.9 1.6 2.0 1.6 0.4 -0.1 0.2
Pack years adult smoking proportion 1.2 1.8 4.4 1.1 2.1 1.3 1.2 1.4 -0.5
Impedance of leg (right) 0.4 2.0 4.2 -1.6 -0.7 -2.0 -2.0 0.0 -0.6
Leg fat-free mass (left) 0.3 1.4 5.3 -0.8 -2.3 -1.0 -0.1 0.3 1.1
Trunk fat percentage 1.4 5.7 12.7 -1.9 -3.6 -3.4 -1.9 1.1 1.5
Hand grip strength (right) 0.1 0.3 0.7 0.1 0.5 0.8 0.4 -0.6 -0.7
Townsend deprivation index at recruitment 1.1 1.6 3.5 -1.9 -1.2 -1.7 -1.3 -0.1 0.0
Current tobacco smoking 2.7 4.4 11.1 2.3 3.3 2.7 1.5 -0.3 -0.7
Average weekly fortified wine intake 0.9 1.1 1.5 -1.1 -0.7 -1.0 -0.9 1.2 1.2
Maternal smoking around birth 1.2 1.8 4.7 0.6 2.2 1.9 0.4 -0.4 -1.3
Fed-up feelings 1.0 1.8 6.3 2.5 0.7 -0.1 1.3 -0.7 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.0 1.4 0.9 1.4 0.5 -0.6 -1.0
Relative age voice broke 0.2 0.3 0.6 -0.7 -0.2 -0.8 -0.8 -0.4 -0.0
Taking other prescription medications 2.0 3.1 6.1 -0.7 -2.5 -2.3 -1.9 -1.3 1.1
Age when periods started (menarche) 0.3 0.8 1.7 -0.8 0.2 0.1 1.0 -1.3 1.3
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.7 0.1 -0.8 -1.0 -1.6 1.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.5 1.9 1.7 1.3 1.5 -0.8 0.2
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 5.2 -2.3 -1.8 0.4 -0.9 0.9 -1.3
Qualifications: CSEs or equivalent 0.9 1.2 3.9 -1.4 -0.2 -0.5 -0.6 -0.8 2.0
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.4 -0.7 0.5 -0.7 -0.9 -0.7
High blood pressure 0.4 1.1 2.5 1.6 -0.9 -1.2 -0.1 0.3 1.4
Hayfever, allergic rhinitis or eczema 0.8 1.7 5.1 1.0 -0.1 -0.4 -0.9 -2.3 -1.8
Multivitamins +/- minerals 0.6 0.8 1.6 -1.1 -0.6 -0.3 -1.3 1.2 -0.2
Stomach or abdominal pain in last month 1.1 1.3 3.5 -1.6 -1.3 -0.4 -1.9 -0.2 0.3
Supplements: Glucosamine 0.8 1.1 3.9 -2.0 -0.6 -0.9 -0.3 -0.3 1.1
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.2 -1.1 -1.8 -1.4 -0.5 -1.0 0.8
Medication: Atenolol 0.4 0.5 1.9 0.1 -0.1 0.3 -0.5 -0.7 1.4
Medication: Levothyroxine sodium 0.2 0.3 0.8 0.9 0.0 0.7 0.2 0.5 0.0
Sitting height 1.6 11.6 29.3 -4.2 -5.4 -3.7 -2.2 1.5 -1.5
Chronic bronchitis/emphysema (father) 1.0 1.1 3.1 1.8 0.6 1.0 1.2 -0.8 -0.3
High blood pressure (mother) 1.1 1.6 3.5 -0.6 -1.9 -1.7 -1.4 -0.9 0.2
Body mass index (BMI) 0.4 1.8 3.2 -0.1 -1.8 -1.8 -0.3 1.2 1.8
Impedance of leg (left) 0.4 2.1 4.5 -1.7 -0.9 -1.9 -2.1 -0.3 -0.7
Leg predicted mass (left) 0.3 1.4 5.3 -0.8 -2.3 -1.0 -0.0 0.2 1.1
Trunk fat mass 1.3 5.7 13.3 -1.9 -3.6 -3.1 -1.6 1.4 1.8
Waist circumference 0.5 2.0 4.1 -0.5 -1.9 -2.0 -0.3 1.1 1.6
Number of incorrect matches in round 3.1 5.2 10.2 1.6 3.0 3.2 2.8 -1.1 0.2
Past tobacco smoking 1.8 3.4 5.5 -1.7 -2.3 -2.0 -2.0 2.1 -0.3
Alcohol usually taken with meals 0.2 0.3 0.9 0.2 -0.5 -0.6 -0.2 0.1 -0.9
Nervous feelings 3.4 6.4 12.5 3.2 3.3 3.5 2.0 -1.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 7.6 2.8 2.2 1.9 1.5 -1.1 -0.1
Hearing difficulty/problems with background noise 1.0 1.6 4.2 -0.9 -1.4 0.1 2.0 0.9 -1.2
Hair/balding pattern: Pattern 2 0.5 0.7 2.3 0.6 0.1 -0.1 1.5 -1.0 -0.5
Had menopause 0.2 0.3 0.9 0.2 0.4 -1.0 -0.6 0.2 -0.3
Had other major operations 1.8 2.3 7.6 -0.7 -1.5 -2.8 -1.3 -0.4 -1.2
Forced vital capacity (FVC) 0.3 1.2 4.5 -2.1 -1.1 -0.8 -0.6 0.1 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.5 1.1 1.0 0.7 0.5 -0.0 1.2
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.6 0.4 -0.1 0.8 0.2 -0.1 -0.3
Qualifications: None of the above 1.5 3.2 6.2 1.2 2.1 2.2 2.5 0.8 -1.2
Financial difficulties in last 2 years 0.4 0.5 1.0 1.0 0.5 1.0 0.7 0.2 0.5
Mouth/teeth dental problems 0.5 0.7 2.1 -1.4 -1.1 -0.6 -0.7 0.2 -0.3
Heart attack 1.2 1.5 4.5 -0.4 1.4 1.6 2.1 -0.4 0.1
Allergy 1.2 2.7 6.6 -0.5 1.1 0.7 1.2 2.4 2.6
Pain all over the body in last month 0.2 0.3 0.5 0.7 0.2 0.7 0.4 0.1 0.6
Diabetes (self-reported) 0.4 0.6 2.6 1.6 -0.2 0.2 0.3 -0.5 0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 1.8 -0.1 -0.2 0.1 -1.3 -0.6 -0.7
Medication: Ramipril 0.4 0.5 2.1 0.3 0.4 -1.4 -0.4 -0.8 0.4
Medication: Simvastatin 0.5 0.7 2.4 0.7 -0.8 -0.5 0.4 1.5 -0.3
Fluid intelligence score 1.1 2.2 3.6 -1.8 -1.9 -1.7 -0.6 1.7 -0.3
Illnesses of siblings 0.5 0.7 2.8 -0.9 0.1 -0.6 0.1 -1.7 -0.1
Neuroticism score 6.1 13.1 22.0 4.7 4.2 4.6 4.2 -0.4 0.2
Weight 0.8 4.0 10.2 -1.6 -3.2 -2.5 -1.0 1.2 1.6
Impedance of arm (right) 0.6 2.9 6.5 -1.7 -1.8 -1.7 -2.5 -0.0 -1.3
Arm fat percentage (right) 0.7 2.9 5.6 -0.4 -2.4 -2.3 -1.3 1.6 1.4
Trunk fat-free mass 0.1 0.6 2.1 -0.8 -1.4 -0.2 0.6 0.7 0.3
Hip circumference 1.4 6.0 16.1 -1.0 -4.0 -3.5 -1.0 1.7 1.6
Time employed in main current job 0.9 1.0 2.9 -0.3 0.2 1.0 0.9 1.7 -1.0
Alcohol intake versus 10 years previously 1.6 2.4 11.7 -0.3 0.6 1.3 -0.5 0.7 3.4
Father’s age at death 0.4 0.5 1.7 -0.1 0.0 0.1 -0.5 -1.0 -1.3
Worrier / anxious feelings 2.4 4.6 9.9 3.1 3.0 2.2 1.7 -0.6 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.0 1.2 0.6 1.7 0.8 -0.7 1.3
Falls in the last year 0.4 0.6 2.8 0.3 -0.3 -0.1 -1.7 0.1 -0.6
Hair/balding pattern: Pattern 3 2.4 3.6 10.7 1.7 3.3 2.6 0.4 0.9 0.0
Number of live births 0.4 0.6 1.3 1.0 0.2 -1.1 -0.6 0.0 -0.9
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 9.0 -3.0 -2.4 -1.6 -1.5 0.5 -0.9
Pulse rate 0.1 0.2 0.5 0.4 -0.7 -0.3 -0.5 -0.5 0.2
Happiness 0.4 0.5 1.2 0.7 -0.0 -0.8 -0.0 0.8 -1.1
Noisy workplace 1.5 1.8 4.1 1.7 1.6 2.0 -0.5 1.0 0.4
Qualifications: A levels/AS levels or equivalent 2.5 5.6 9.7 -2.2 -3.1 -3.0 -2.7 0.3 -1.5
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 10.0 1.5 -0.2 0.4 0.4 -0.7 3.2
Mouth/teeth dental problems: Dentures 0.4 0.7 1.4 1.2 1.2 0.8 0.0 0.8 -0.7
Asthma 0.6 1.1 2.0 1.0 -1.2 -0.3 0.6 -1.4 -1.4
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.2 6.5 2.6 2.2 2.5 2.2 -1.2 1.1
Medication: Cholesterol lowering 0.4 0.6 1.6 1.2 0.6 1.0 0.5 0.7 0.3
Depression (self-reported) 0.6 0.7 1.6 1.3 -0.8 -0.4 0.7 -0.9 0.8
Medication: Lansoprazole 1.5 1.7 4.4 -2.1 -0.8 -0.6 -0.9 -1.5 1.4
Prospective memory result 3.2 3.9 10.3 3.2 2.8 2.0 1.1 -0.4 0.7
Lung cancer (father) 1.0 1.2 5.5 0.5 0.0 -0.3 -0.6 1.0 -2.3
Illnesses of mother 0.3 0.3 0.8 -0.3 0.9 0.4 0.0 0.6 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 6.5 -2.5 -1.8 -1.1 -1.4 0.3 -0.8
Pulse wave Arterial Stiffness index 0.7 0.8 1.3 -0.1 -0.8 -0.7 -1.1 1.0 1.1
Impedance of arm (left) 0.7 3.2 7.0 -2.1 -2.0 -1.7 -2.6 -0.6 -0.9
Arm fat mass (right) 0.7 2.9 5.6 -0.8 -2.4 -2.2 -0.8 1.6 1.7
Trunk predicted mass 0.1 0.6 2.1 -0.8 -1.4 -0.3 0.6 0.7 0.3
Standing height 0.5 5.0 12.0 -3.4 -3.5 -1.9 -1.6 0.5 -0.4
Length of working week for main job 0.5 0.6 1.7 0.9 0.2 -0.4 -0.1 -1.3 1.0
Exposure to tobacco smoke at home 0.6 0.7 2.3 -1.1 0.3 -0.4 0.1 1.5 -0.5
Breastfed as a baby 1.5 1.9 5.2 -1.2 -0.9 -1.5 -2.3 0.7 0.9
Tense / ‘highly strung’ 2.8 4.7 8.5 2.0 2.2 2.9 2.0 -0.9 2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 7.0 0.3 -0.2 0.1 -0.2 -2.6 -0.0
Hair/balding pattern: Pattern 4 1.0 2.5 5.8 0.6 1.0 2.4 2.3 0.9 1.4
Birth weight of first child 0.7 1.2 3.4 -1.1 -0.5 -0.4 -1.5 0.2 -1.8
Peak expiratory flow (PEF) 3.1 7.2 14.8 -3.8 -3.9 -2.9 -2.1 0.6 -1.1
Pulse wave reflection index 0.6 0.7 1.7 -0.2 -1.1 -1.3 -1.0 -0.0 0.4
Ever highly irritable/argumentative for 2 days 1.8 2.1 3.8 1.0 1.5 1.5 1.9 -1.9 -0.0
Loud music exposure frequency 0.5 0.5 1.8 -0.4 0.3 -0.2 0.0 1.0 1.3
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 4.7 -1.4 -1.8 -2.2 -1.0 -0.9 0.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.0 0.9 0.2 -0.1 0.8 -0.4 1.4
Blood clot in the leg (DVT) 0.7 0.9 4.6 2.2 0.2 -0.2 0.1 0.9 -0.2
Medication: Paracetamol 0.5 0.9 2.9 0.9 -0.7 -0.9 -0.2 -1.7 -0.6
Headache pain in last month 0.7 1.1 3.7 -0.6 -1.9 -0.6 -0.3 -0.8 1.3
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 4.3 -2.1 -0.9 -0.9 -1.2 -0.6 -1.0
Glaucoma (self-reported) 1.2 1.4 3.7 -0.4 -1.9 -0.9 -1.0 1.4 0.7
Gout (self-reported) 1.6 2.2 6.3 -1.0 -1.0 -1.1 -1.8 0.5 -2.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.0 1.7 0.2 1.0 1.0 -1.5 -0.8
Medication: Amlodipine 0.1 0.2 0.6 0.0 0.3 0.0 0.5 -0.1 0.8
Medication: Ventolin 100micrograms inhaler 1.7 2.1 7.0 0.5 -0.2 -0.3 0.6 -2.6 -2.3
Birth weight 2.8 6.0 11.5 -2.5 -2.6 -2.0 -3.4 -1.9 -1.9
Chronic bronchitis/emphysema (mother) 1.6 1.9 10.4 0.2 0.5 0.3 -0.6 -0.1 -3.2
High blood pressure (siblings) 0.3 0.4 1.0 -0.6 -1.0 -0.7 -0.6 0.2 0.2
Forced vital capacity (FVC), Best measure 0.3 1.3 5.1 -2.2 -0.9 -0.7 -0.5 0.0 -0.9
Body fat percentage 1.2 5.0 10.3 -1.5 -3.1 -3.2 -1.8 1.3 1.8
Leg fat percentage (right) 0.8 3.1 7.5 -0.6 -2.0 -2.7 -1.0 1.8 1.6
Arm fat-free mass (right) 0.2 0.8 2.5 -0.8 -1.6 -0.5 0.6 0.4 1.1
Exposure to tobacco smoke outside home 2.1 2.7 9.8 3.1 2.2 0.6 1.1 0.1 0.8
Comparative body size at age 10 0.8 2.3 3.8 -0.3 1.8 1.1 1.5 -1.7 1.9
Number of full brothers 1.2 1.6 3.3 -1.1 -1.8 -0.8 -0.7 0.7 -1.8
Worry too long after embarrassment 1.3 2.2 4.5 1.5 1.9 2.1 1.5 0.2 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.1 0.4 0.2 1.2 -0.3 -1.8 0.8
Wheeze or whistling in the chest in last year 2.0 3.6 7.7 2.8 1.5 1.5 2.2 -0.8 -2.0
Number of children fathered 1.3 1.4 3.1 1.5 0.4 -0.3 -1.8 1.3 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.5 1.0 1.6 0.9 0.4 0.1 -0.2
Age at first live birth 0.5 0.9 2.3 -0.5 0.4 1.0 -0.0 1.5 -1.4
Pulse wave peak to peak time 0.5 0.6 1.2 -0.1 0.5 0.6 1.0 -1.0 -1.1
Health satisfaction 0.4 0.6 1.7 -0.1 0.0 -0.7 -0.4 -1.3 1.0
Shortness of breath walking on level ground 1.9 2.3 6.6 0.7 1.9 2.6 1.6 0.7 0.6
Qualifications: College or University degree 2.6 8.3 21.9 -2.8 -4.7 -3.5 -2.7 0.6 -0.2
Eye problems/disorders: None of the above 0.9 1.1 4.3 -2.1 0.9 0.4 -0.1 1.0 -0.2
Mouth/teeth dental problems: Loose teeth 1.4 1.7 3.1 1.6 1.8 1.7 1.1 -0.6 -0.3
Emphysema/chronic bronchitis 0.5 0.6 1.9 -1.2 -0.4 -0.1 -1.4 -0.4 0.1
Medication for pain relief, constipation, heartburn 0.7 1.2 1.6 -1.1 -0.8 -1.2 -1.2 0.8 -1.3
Neck or shoulder pain in last month 1.0 1.4 3.6 0.2 0.9 1.1 1.9 -1.6 -0.6
Medication: Blood pressure 0.9 1.5 3.9 2.0 0.3 0.8 1.4 0.8 1.4
Angina (self-reported) 0.2 0.2 0.7 -0.8 0.3 0.1 -0.2 0.7 -0.3
Migraine (self-reported) 0.8 0.9 2.1 -0.4 -1.4 -0.1 -0.7 -1.4 -1.0
Medication: Ibuprofen 1.3 1.6 3.0 1.4 1.1 1.2 1.7 -1.2 0.8
Medication: Allopurinol 0.6 0.8 2.4 -0.5 -0.8 -0.7 -0.8 0.5 -1.5
Medication: Omeprazole 0.7 0.9 2.3 0.6 0.7 0.8 1.1 -1.5 0.5
Medication: Seretide 50 evohaler 1.3 1.5 3.6 1.0 0.3 0.6 0.9 -1.8 -1.9
Mean time to correctly identify matches 6.0 11.5 22.1 4.4 4.7 3.5 3.8 0.0 1.2
Heart disease (mother) 0.9 1.1 2.9 1.2 -0.5 -0.5 -0.8 -1.2 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.0 0.4 0.9 0.7 1.4 -0.8 1.4
Whole body fat mass 1.0 4.2 9.1 -1.3 -3.0 -2.7 -1.2 1.4 1.9
Leg fat mass (right) 0.9 3.6 7.1 -0.9 -2.5 -2.7 -1.1 1.5 2.0
Arm predicted mass (right) 0.2 0.9 2.3 -1.0 -1.5 -0.5 0.7 0.1 1.1
Pulse rate, automated reading 0.1 0.4 1.6 1.3 0.3 0.1 -0.3 0.2 0.8
Alcohol intake frequency. 0.4 0.9 3.6 1.3 -0.2 0.4 -0.0 -0.1 1.9
Comparative height size at age 10 0.2 1.0 2.2 -1.2 -1.5 -1.0 -1.0 -0.1 -0.4
Number of full sisters 0.8 0.9 3.1 -1.3 -1.8 -0.2 -0.8 0.6 -0.1
Suffer from ‘nerves’ 3.1 5.0 14.6 2.5 2.5 3.8 1.7 0.3 -0.3
Overall health rating 0.4 0.8 2.3 1.1 -0.4 -1.5 -0.5 -1.0 -0.2
Chest pain or discomfort 0.2 0.2 0.9 0.9 0.3 0.6 -0.2 -0.2 0.2
Had major operations 0.2 0.3 0.8 0.2 -0.0 0.9 0.7 -0.6 -0.2
Age at last live birth 0.6 0.9 2.8 0.7 0.5 -0.2 -0.4 1.2 -1.7
Family relationship satisfaction 1.0 1.2 2.0 -0.1 -1.0 -1.2 -1.4 1.3 -1.1
Leg pain on walking 0.9 1.1 4.7 0.6 0.3 0.6 0.2 -1.0 2.2
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.4 1.0 0.6 0.7 0.6 -1.6 1.1
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.3 0.5 1.1 0.8 0.7 1.1 -0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.0 -0.2 -0.0 -0.7 1.4 0.2 -0.6
Medication: Aspirin 0.2 0.3 1.4 -0.3 0.0 0.2 0.0 1.2 -0.1
Supplements: Vitamin C 1.0 1.2 3.3 0.3 0.2 1.8 0.7 -1.1 -1.4
Knee pain experienced in last month 0.8 1.2 4.2 0.7 2.0 0.9 1.1 -0.7 0.4
Hypertension (Self-reported) 0.4 1.0 2.2 1.2 -0.9 -1.5 -0.3 0.1 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 3.0 -0.1 -1.0 0.1 0.1 -1.0 1.7
Illnesses of father: Heart disease 0.7 0.9 2.4 1.6 0.7 0.0 1.2 -0.9 0.5
Illnesses of siblings: Diabetes 0.8 1.0 2.8 -0.5 -1.7 -0.0 0.9 1.2 0.6
Smoking status: Previous 0.9 1.4 3.3 0.8 1.4 1.2 1.1 -1.8 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.7 0.8 -0.6 0.0 0.6 -0.7 0.2
Whole body fat-free mass 0.1 0.8 3.1 -0.8 -1.8 -0.4 0.5 0.5 0.7
Leg fat-free mass (right) 0.2 1.0 4.6 -0.6 -2.1 -0.6 0.2 0.1 0.8
Arm fat percentage (left) 0.8 3.5 7.4 -0.8 -2.7 -2.5 -1.5 1.2 1.7
Average weekly red wine intake 0.3 0.5 0.8 -0.6 -0.8 -0.6 0.5 0.7 -0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 0.7 0.3 -0.9 -0.3 0.9 0.2
Mood swings 8.7 16.1 28.8 4.4 4.3 5.4 5.0 -1.9 1.1
Loneliness, isolation 0.6 0.9 2.3 1.5 -0.1 1.1 0.3 1.2 -0.5
Long-standing illness, disability or infirmity 1.4 2.1 5.2 1.4 -0.6 -1.1 -1.2 -2.3 -1.7
Ever had bowel cancer screening 1.1 1.2 6.0 -2.5 -0.4 -0.3 -0.8 -0.5 0.6
Diabetes diagnosed by doctor 0.3 0.6 1.6 1.2 -0.1 0.3 0.3 -1.2 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.4 -0.3 -0.6 -0.3 -0.1 0.0 0.1
Friendships satisfaction 0.5 0.6 2.4 0.2 -0.6 -0.3 -0.9 1.5 0.0
Qualifications: nursing, teaching 1.5 2.4 6.3 -1.0 -2.1 -1.5 -2.5 0.7 0.2
Commuting to job workplace: Walk 0.3 0.4 1.3 -0.4 0.1 0.4 -0.2 0.8 -1.1
Eye problems/disorders: Cataract 1.8 2.1 10.1 1.1 0.5 0.0 0.4 -3.2 0.8
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.1 -0.2 -0.1 0.1 1.4 0.9 -0.8
Medication for cholesterol 0.4 0.6 1.8 0.2 0.3 1.4 0.3 1.0 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 5.7 -0.1 0.3 2.4 1.4 0.6 0.5
Back pain experienced in last month 0.6 1.0 1.5 0.9 0.9 0.9 0.8 1.2 1.1
Mineral and other dietary supplements 1.0 1.3 3.5 1.9 1.5 0.9 0.9 -0.1 0.5
Breast cancer (self-reported) 1.9 2.3 6.3 -0.4 -0.6 -1.4 -0.6 2.1 -2.5
Asthma (self-reported) 0.6 1.1 1.8 0.9 -1.2 -0.2 0.7 -1.3 -1.3
Osteoporosis (self-reported) 2.3 2.9 8.8 -3.0 -1.4 -0.9 -1.8 1.5 -0.5
Osteoarthritis (self-reported) 2.1 2.8 6.9 -0.0 2.6 2.0 2.3 -0.8 -0.3
Medication: Aspirin 0.4 0.6 1.8 0.2 0.6 0.7 0.8 1.3 -0.3
Medication: Gliclazide 1.4 1.5 2.7 0.6 -0.9 -1.7 -1.5 -1.6 -0.7
Illnesses of father: None of the above (group 1) 0.7 0.8 2.4 -1.5 -0.5 -0.0 -1.0 0.9 0.7
Smoking status: Current 2.6 4.2 9.5 2.3 3.1 2.6 1.4 -0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 3.7 -1.2 -0.0 -0.6 -0.7 1.9 -1.8
Whole body water mass 0.1 0.8 3.3 -0.7 -1.8 -0.4 0.5 0.5 0.7
Leg predicted mass (right) 0.2 1.1 4.9 -0.7 -2.2 -0.6 0.1 0.1 0.8
Arm fat mass (left) 0.8 3.4 8.0 -1.0 -2.8 -2.3 -1.1 1.3 1.8
Number of self-reported non-cancer illnesses 1.1 1.9 5.9 0.1 -2.0 -0.8 -0.8 -2.4 0.1
Average weekly champagne plus white wine intake 0.5 0.7 1.8 1.0 0.9 0.4 0.2 -0.7 1.4
Miserableness 1.1 2.0 5.6 1.3 0.8 1.8 2.4 -0.8 -0.5
Guilty feelings 3.6 5.5 11.6 3.4 2.5 2.7 2.6 0.1 0.8
Wears glasses or contact lenses 0.6 0.7 1.4 0.8 -0.5 -1.1 0.7 1.2 -0.5
Ever taken oral contraceptive pill 0.4 0.4 1.6 -0.2 0.7 0.6 -0.0 0.4 -1.3
Hearing aid user 0.7 0.8 2.9 0.4 0.9 0.1 1.0 1.7 0.2
Mother’s age at death 1.3 1.7 6.3 -0.4 0.1 1.5 -0.6 1.0 -2.5
Financial situation satisfaction 1.3 1.7 3.0 1.7 1.7 0.4 -0.1 -1.4 1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 -0.8 -1.1 -0.9 -0.9 -0.3 -0.3
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.1 -0.3 -0.4 0.5 -0.4 0.4
Eye problems/disorders: Glaucoma 1.2 1.5 5.2 -0.7 -1.6 -0.2 0.3 2.3 0.5
Medication: Blood pressure 0.9 1.7 6.6 -0.7 -0.8 -2.6 -1.4 -0.1 0.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.3 1.5 1.2 1.0 0.8 -0.8 -1.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.5 -1.2 -1.0 -1.2 -1.0 -0.6 -0.1
High cholesterol (Self-reported) 0.1 0.2 0.4 -0.4 -0.4 -0.1 -0.5 0.5 -0.6
Medication: Bendroflumethiazide 0.8 1.3 4.1 -0.5 -1.1 -1.4 -0.5 0.1 2.0
Medication: Paracetamol 0.4 0.6 1.9 1.1 -0.1 -0.4 -0.0 -1.4 -0.3
Medication: Lisinopril 0.6 0.7 2.1 0.6 -1.5 -0.6 0.2 1.2 -0.4
Medication: Atorvastatin 0.7 0.9 2.6 -0.0 1.6 1.3 1.0 -0.1 -0.2
Illnesses of father: High blood pressure 0.8 1.0 2.4 1.6 1.3 0.7 0.9 -0.7 -0.1
Alcohol drinker status: Never 1.1 1.3 3.8 -0.5 -1.8 -2.0 -0.6 0.1 0.3
Ever smoked 2.0 3.5 6.0 1.9 2.2 1.8 1.6 -2.4 0.7
Basal metabolic rate 0.3 1.4 5.0 -1.0 -2.2 -1.0 0.1 0.7 0.9
Leg fat percentage (left) 0.9 3.2 7.5 -0.6 -2.2 -2.7 -1.1 1.7 1.6
Arm fat-free mass (left) 0.1 0.6 1.6 -0.6 -1.3 -0.3 0.8 0.9 0.6
Number of operations (self-reported) 1.3 2.0 3.5 0.7 -1.1 -1.9 -1.7 -1.9 -0.5
Average weekly beer plus cider intake 0.8 1.2 3.6 -0.4 0.0 0.4 1.5 1.9 -1.1
Irritability 2.0 3.4 6.3 1.7 2.5 1.8 2.4 -1.1 0.9
Risk taking 0.8 1.1 3.0 -1.5 -1.7 0.3 -0.8 -0.7 -0.4
Ever had prostate specific antigen (PSA) test 1.8 2.0 6.8 1.2 1.2 1.2 2.6 0.4 0.9
Fractured/broken bones in last 5 years 0.7 0.9 2.4 -0.4 -0.7 -1.1 -1.6 0.5 0.9
Age started oral contraceptive pill 1.7 2.1 8.4 -1.3 0.1 0.2 0.3 2.9 -1.6
Diastolic blood pressure, automated reading 2.0 6.2 12.8 -2.0 -3.6 -3.5 -2.8 0.7 -0.2
Ever depressed for a whole week 0.1 0.2 0.4 0.3 0.0 0.5 -0.6 0.3 -0.5
Unable to work because of sickness or disability 0.4 0.5 2.7 1.7 0.4 0.1 -0.1 0.1 0.6
Commuting to job workplace: Cycle 0.4 0.5 1.9 -0.2 -1.4 -0.8 -0.1 0.2 -0.7
Myopia 0.4 0.6 1.4 -0.2 0.4 0.9 -0.5 -1.2 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.8 -1.3 0.3 0.7 -0.4 0.0 -1.4
Cholesterol lowering medication 0.2 0.4 0.6 -0.4 0.3 -0.6 0.8 0.8 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 3.3 -0.0 0.9 0.8 0.5 -1.8 0.7
Pain experienced in last month 1.4 2.3 4.2 -1.8 -1.3 -1.6 -2.0 1.5 -0.5
Supplements: Calcium 1.8 2.0 4.4 -2.1 -1.6 -0.8 -1.8 -0.5 0.9
Basal cell carcinoma (self-reported) 1.1 1.4 4.5 -0.7 -1.2 -0.5 -1.3 0.2 -2.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.6 -0.5 1.1 1.3 1.9 -0.2 0.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 5.7 2.4 0.5 -0.2 0.2 1.0 -0.6
Heart disease (siblings) 1.5 1.8 8.2 -0.2 -1.1 -0.1 -0.2 2.9 1.1
Alcohol drinker status: Previous 0.3 0.3 0.9 0.9 -0.4 -0.6 0.4 -0.4 0.1
Pack years of smoking 2.0 2.9 6.0 1.5 2.4 1.8 1.8 1.7 -0.2
Impedance of whole body 0.5 2.7 6.0 -1.9 -1.4 -1.9 -2.5 -0.5 -0.8
Leg fat mass (left) 1.0 4.0 7.9 -1.0 -2.8 -2.8 -1.2 1.4 2.0
Arm predicted mass (left) 0.2 0.9 2.2 -1.1 -1.5 -0.6 0.3 0.8 0.7