Hub : Genes

MESP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2650	0.0930	1.2e-03	0.055	NA	0.049	NA	0.025	1.0e-02	NA	1.5e-02	NA	6.0e-02
2	GTEx	Esophagus Mucosa	0.1680	0.0430	6.8e-08	0.139	NA	0.136	NA	0.125	1.5e-09	NA	2.2e-09	NA	1.1e-08
3	GTEx	Testis	0.1220	0.0510	5.2e-03	0.036	NA	0.019	NA	0.022	1.1e-02	NA	4.8e-02	NA	3.5e-02
4	GTEx	Thyroid	0.1330	0.0440	1.2e-04	0.060	NA	0.008	NA	0.031	2.1e-05	NA	8.0e-02	NA	1.9e-03
5	TCGA	Prostate Adenocarcinoma	0.0674	0.0328	3.7e-08	0.075	0.069	0.060	NA	0.057	2.8e-08	9.5e-08	6.2e-07	NA	1.2e-06
6	TCGA	Thyroid Carcinoma	0.0780	0.0340	2.8e-13	0.135	0.140	0.137	NA	0.149	4.4e-13	1.6e-13	2.7e-13	NA	2.2e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.9	0.5	0.4	0.5	-0.1	0.6
Bipolar Disorder or Schizophrenia	0.7	1.7	2.9	0.0	1.1	1.6	1.4	-1.2	1.7
Depressed Affect (Nagel 2018)	1.1	2.4	4.4	-2.1	1.8	1.1	1.8	-0.7	1.4
Depression (Nagel 2018)	0.4	0.6	1.0	-1.0	0.9	0.3	0.9	-0.0	0.9
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.0	1.1	-1.4	-1.0	-1.1	1.3	-2.0
Neuroticism (Nagel 2018)	0.4	0.8	2.5	-1.6	1.4	0.3	0.4	0.2	0.4
Schizophrenia (2018)	0.9	1.9	2.9	0.7	1.0	1.7	1.4	-1.4	1.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.6	-0.2	0.0	-0.2	0.0	-0.3
Worry (Nagel 2018)	0.5	1.1	4.6	-2.1	1.0	0.3	0.7	0.1	0.4
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	-0.4	-0.4	-0.7	-0.9	0.3	-0.4
Alzheimer’s Disease (in father)	3.1	3.4	7.2	-0.5	-2.7	-1.6	-1.7	1.6	-2.2
Alzheimer’s Disease (including proxy)	2.2	3.2	5.3	-0.6	-2.3	-1.8	-2.0	1.4	-2.0
Crohns Disease (2017)	0.1	0.3	1.3	0.1	-0.6	-0.1	-1.1	-0.2	-0.4
Irritable Bowel Disease (IBD)	0.3	0.6	1.7	-0.2	0.0	1.0	0.5	-1.3	0.8
Ulcerative Colitis (UC)	1.3	2.4	4.1	-0.2	0.8	1.7	2.0	-1.9	1.8
Major Depression (MDD)	0.1	0.2	0.3	-0.4	-0.1	-0.5	0.5	0.5	-0.3
Reaction Time	0.8	1.5	3.2	1.8	-1.1	-1.2	-0.8	1.3	-1.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.1	0.1	0.4	-0.4	-0.1	-0.4
Breast Cancer	1.0	2.5	5.3	-1.5	1.5	2.3	1.3	-1.3	1.4
Ovarian Cancer	0.4	0.5	1.1	1.0	-0.6	-0.4	-1.0	0.4	-0.6
Prostate Cancer	3.8	5.3	9.8	-1.8	3.1	2.5	1.6	-2.4	2.1
Age at First Birth	0.8	1.2	3.0	-0.1	1.3	1.3	0.7	-0.8	1.7
Bipolar Disorder (2011)	0.9	0.8	3.0	-1.7	0.2	0.4	1.1	-0.3	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-1.0	-0.4	-0.1	0.7	-0.7	0.0
Coronary Artery Disease (CAD)	1.4	1.6	2.8	-1.2	1.4	1.7	1.4	-0.8	0.8
Crohns Disease (2012)	0.1	0.1	0.3	-0.0	-0.3	0.5	-0.4	0.0	-0.5
Mean Putamen Volume	0.9	1.1	1.8	0.5	-0.9	-1.4	-1.0	1.1	-1.2
Fasting Glucose	2.1	2.5	4.8	-0.0	-1.6	-1.7	-2.2	1.5	-1.6
HbA1C	5.3	5.9	7.1	-2.2	2.7	2.4	2.4	-2.4	2.4
HDL Cholesterol	0.2	0.4	1.2	1.1	0.2	0.2	0.6	-0.2	0.7
LDL Cholesterol	0.5	0.9	1.7	1.1	-0.6	-0.9	-0.5	0.9	-1.3
Lupus	0.4	0.7	2.1	0.3	0.7	0.5	1.4	-1.0	0.3
Neuroticism (2016)	0.1	0.2	0.8	-0.4	0.9	-0.1	0.3	0.2	0.2
Primary Biliary Cirrhosis	1.2	1.7	6.0	0.6	0.9	0.6	2.4	-0.7	1.5
Rheumatoid Arthritis	0.2	0.3	0.9	-0.3	-0.6	-0.7	0.3	0.2	-0.9
Schizophrenia (2014)	0.8	1.7	2.9	0.2	1.1	1.7	1.2	-1.3	1.7
Triglycerides	0.1	0.2	0.9	0.2	0.2	0.6	0.3	-1.0	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.7	0.3	0.8	0.6	-0.5	-0.4	0.3
Ulcerative Colitis	0.9	1.3	2.7	0.4	0.5	1.1	1.6	-1.4	1.3
Blood Eosinophil Count	0.6	4.8	7.1	2.1	-1.5	-2.0	-2.7	2.2	-2.5
Blood Platelet Count	0.9	10.6	26.9	0.2	-5.2	-2.8	-2.4	3.1	-3.7
Blood Red Count	0.1	0.9	2.0	0.8	-0.4	-1.4	-0.0	1.4	-0.9
Blood White Count	0.4	3.0	10.0	3.2	-1.4	-0.3	-0.7	1.7	-1.5
Heel T-Score	0.8	6.3	14.2	0.6	-1.8	-2.6	-3.8	2.3	-2.8
BMI	0.2	1.4	2.5	-1.6	0.2	0.6	1.6	-0.9	1.4
Height	0.1	1.9	7.8	0.2	-2.8	-1.2	-0.5	0.2	-1.5
Waist Hip Ratio (WHR)	0.1	0.2	0.7	-0.4	0.4	0.2	0.8	0.4	-0.4
Systolic Blood Pressure	0.4	1.8	6.6	2.6	-0.5	-0.4	-1.5	0.6	-1.0
Smoking Status	0.1	0.2	1.0	1.0	0.1	0.2	-0.3	0.0	-0.1
Allergy or Eczema	0.1	0.3	0.8	0.9	-0.1	-0.4	-0.1	0.3	-0.8
Cardiovascular Disease	0.1	0.2	0.5	0.6	0.3	-0.3	-0.7	0.1	-0.1
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.8	-0.1	-0.1	-0.1	-0.5	0.3
Respiratory disease	1.8	3.9	6.3	-0.2	1.6	2.0	2.4	-2.4	2.5
Type 2 Diabetes (T2D) (2018)	0.7	1.4	5.3	1.4	2.3	-0.7	-0.6	0.2	0.1
Lung FEV1/FVC ratio	0.2	0.8	2.6	-1.0	0.9	0.3	-1.6	0.3	0.2
Lung FVC	1.6	8.1	12.7	-0.2	-3.3	-3.6	-2.5	3.1	-3.0
Neuroticism	0.1	0.3	1.0	-0.4	0.5	-0.4	0.1	1.0	-0.3
Chronotype (morning person)	0.1	0.3	1.0	-1.0	0.2	0.2	0.5	-0.4	0.7
Hair Pigment	0.0	1.4	3.5	-0.9	1.9	1.2	0.8	-0.8	1.2
Tanning	0.5	6.1	7.3	2.0	-2.7	-2.3	-2.5	2.6	-2.7
Hand grip strength (left)	0.6	1.7	3.9	0.6	-2.0	-1.1	-0.9	1.1	-1.6
Number of treatments/medications taken	0.2	0.3	1.7	1.3	-0.0	0.1	0.4	-0.0	-0.4
Average weekly spirits intake	0.1	0.1	0.3	-0.4	-0.2	0.4	0.3	-0.3	0.5
Sensitivity / hurt feelings	1.8	3.1	4.1	1.5	-1.4	-1.9	-2.0	2.0	-1.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	0.1	0.9	-0.0	0.3	0.2	0.6
Hearing difficulty/problems: Yes	0.4	0.6	3.1	-1.8	-0.3	0.0	-0.3	0.3	-0.1
Relative age of first facial hair	0.1	0.2	0.4	-0.6	-0.0	0.3	0.6	-0.2	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.4	1.2	-0.3	0.0	-0.4	-0.3	0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.6	2.3	-1.5	-0.1	-0.9	0.2	0.2	-0.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.3	-0.4	-0.2	0.8	-0.1	-0.4
Systolic blood pressure, automated reading	0.2	0.7	1.3	0.9	-0.5	-0.8	-1.1	0.6	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.4	0.5	-0.1	-0.8	0.2	-0.1
Angina	0.1	0.1	0.4	-0.1	-0.4	0.1	-0.6	-0.1	-0.4
Medication for hormone replacement therapy	0.5	0.6	1.8	-1.3	0.9	0.4	0.5	-0.7	0.2
Vitamin and mineral supplements	0.1	0.1	0.3	-0.1	0.6	0.1	0.0	-0.1	0.4
Supplements: Zinc	1.8	1.9	3.8	0.7	-1.8	-2.0	-0.6	1.1	-1.5
Medication: Co-codamol	1.8	2.0	3.7	-0.5	-1.6	-1.5	-0.9	1.9	-1.7
Medication: Metformin	1.3	1.9	3.5	1.9	1.3	-1.7	-1.2	1.3	-0.6
Diabetes (father)	0.8	1.0	5.0	-0.1	2.2	0.5	-0.2	-0.5	0.8
Diabetes (mother)	1.1	1.4	3.2	-1.1	1.8	0.9	0.8	-0.7	1.4
Severe depression (siblings)	0.8	0.8	1.6	-0.4	1.1	1.2	0.5	-0.8	1.0
Pack years adult smoking proportion	0.5	0.8	2.9	-0.3	-1.7	-0.6	0.6	0.2	-0.8
Impedance of leg (right)	0.0	0.1	0.4	0.6	-0.1	-0.1	-0.0	0.1	-0.6
Leg fat-free mass (left)	0.0	0.2	0.7	-0.7	-0.8	-0.3	0.1	-0.0	0.0
Trunk fat percentage	0.0	0.2	0.3	-0.5	-0.5	-0.6	0.5	0.0	0.0
Hand grip strength (right)	0.4	1.2	2.5	0.8	-1.6	-0.8	-1.2	0.8	-1.1
Townsend deprivation index at recruitment	0.3	0.4	1.3	-0.7	0.3	1.1	-0.1	-0.3	0.5
Current tobacco smoking	0.2	0.3	0.8	0.4	0.5	0.1	0.9	-0.8	0.2
Average weekly fortified wine intake	2.3	2.7	4.5	-1.9	1.2	2.1	1.4	-1.3	1.7
Maternal smoking around birth	0.0	0.1	0.1	-0.2	0.3	0.3	-0.1	0.2	-0.2
Fed-up feelings	0.4	0.7	2.5	-1.6	0.8	-0.5	0.6	0.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	0.2	-0.6	-0.9	-0.3	1.1	-0.4
Relative age voice broke	0.0	0.0	0.1	-0.1	0.2	0.1	-0.3	0.1	0.1
Taking other prescription medications	0.7	1.1	4.6	2.1	-0.8	0.0	0.3	0.7	-0.7
Age when periods started (menarche)	0.1	0.2	0.5	0.4	-0.4	-0.1	-0.7	0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	0.0	0.2	-0.8	-1.0	0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	1.1	-1.1	-0.9	-1.4	0.4	-1.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.1	-1.8	0.5	0.1	1.1	-1.2	0.9
Qualifications: CSEs or equivalent	1.8	2.3	4.4	-1.5	1.2	1.2	2.1	-1.3	1.6
Serious illness, injury or assault to yourself	0.5	0.6	2.0	-0.3	0.3	0.5	0.5	-1.4	0.9
High blood pressure	0.4	1.2	3.8	1.9	-0.5	-0.9	-0.9	0.6	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.5	0.9	-0.7	-0.9	-0.6	0.9	-1.2
Multivitamins +/- minerals	1.4	1.7	3.8	0.9	-1.9	-1.1	-1.1	1.1	-1.5
Stomach or abdominal pain in last month	0.2	0.3	0.4	0.7	-0.6	-0.6	0.2	0.6	-0.4
Supplements: Glucosamine	0.2	0.2	0.9	1.0	-0.4	0.3	0.5	-0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.1	1.5	0.6	0.6	1.2	-0.8	0.8
Medication: Atenolol	0.3	0.3	0.6	0.3	-0.7	-0.8	0.5	0.3	-0.5
Medication: Levothyroxine sodium	0.6	1.1	2.9	-0.4	0.4	0.5	1.0	-1.7	1.4
Sitting height	0.0	0.1	0.2	-0.1	-0.3	-0.5	-0.3	-0.4	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.4	0.3	-0.3	0.1	0.0	0.0
High blood pressure (mother)	0.3	0.5	1.0	0.6	-0.6	-0.1	-1.0	0.9	-0.4
Body mass index (BMI)	0.3	1.5	3.6	-1.9	0.5	0.8	1.2	-1.1	1.3
Impedance of leg (left)	0.1	0.5	0.9	0.9	-0.5	-0.8	-0.4	0.6	-0.8
Leg predicted mass (left)	0.0	0.2	0.8	-0.7	-0.9	-0.2	0.1	-0.0	0.0
Trunk fat mass	0.1	0.3	1.0	-1.0	-0.4	-0.2	0.6	-0.4	0.4
Waist circumference	0.5	1.9	5.9	-2.4	0.3	0.8	1.6	-1.1	1.1
Number of incorrect matches in round	3.4	5.6	8.0	2.1	-2.0	-2.3	-2.6	2.8	-2.3
Past tobacco smoking	0.8	1.4	4.5	-1.5	0.4	0.6	2.1	-0.9	0.6
Alcohol usually taken with meals	0.1	0.2	0.7	0.3	-0.4	-0.2	-0.5	0.2	-0.9
Nervous feelings	0.2	0.4	1.5	-0.6	1.2	0.4	0.5	0.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.3	-0.4	1.1	-0.7	-0.1	0.5	0.1
Hearing difficulty/problems with background noise	0.2	0.4	1.8	-1.3	-0.2	-0.2	-0.6	0.2	-0.2
Hair/balding pattern: Pattern 2	0.4	0.6	2.6	-0.3	0.2	0.8	1.6	-0.0	0.3
Had menopause	0.5	0.6	1.3	-1.0	-0.6	-1.1	-0.4	0.6	-0.8
Had other major operations	2.4	2.9	5.7	1.2	-1.5	-2.4	-0.6	1.8	-2.1
Forced vital capacity (FVC)	0.8	3.0	5.3	-0.4	-2.3	-2.1	-1.4	1.8	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.9	1.4	-0.7	-1.2	-1.7	0.6	-1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.6	1.3	-0.1	-0.1	0.1	0.6	-0.4
Qualifications: None of the above	0.1	0.1	0.2	-0.4	0.5	-0.2	-0.4	0.2	0.5
Financial difficulties in last 2 years	0.5	0.6	1.4	1.2	-0.1	-0.2	-1.2	0.8	-0.6
Mouth/teeth dental problems	0.5	0.8	1.1	-1.0	0.9	0.7	0.6	-1.0	0.9
Heart attack	0.5	0.7	1.4	-0.5	-0.6	-1.1	-1.2	0.7	-0.7
Allergy	0.2	0.5	1.3	-0.3	-0.4	-0.7	-1.1	0.7	-0.6
Pain all over the body in last month	1.2	1.2	5.2	0.3	-0.1	0.8	2.3	-0.8	0.9
Diabetes (self-reported)	1.0	1.6	5.2	2.3	1.0	-1.1	-1.0	0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.0	-0.0	-1.0	-0.9	-0.9	0.5	-0.8
Medication: Ramipril	1.1	1.4	4.6	2.1	-0.4	-1.4	-0.4	1.0	-0.8
Medication: Simvastatin	0.5	0.7	1.6	1.3	-0.3	-0.4	-0.1	1.1	-1.1
Fluid intelligence score	0.4	0.7	1.3	1.1	-0.6	-0.3	-1.0	0.7	-1.1
Illnesses of siblings	0.2	0.2	0.7	-0.1	-0.8	-0.4	0.4	0.1	-0.7
Neuroticism score	0.7	1.5	4.0	-0.1	-0.4	-1.6	-1.0	2.0	-1.2
Weight	0.2	0.9	2.8	-1.7	-0.3	0.4	1.1	-0.9	0.8
Impedance of arm (right)	0.7	3.2	6.4	2.5	-1.0	-1.8	-1.1	1.8	-2.0
Arm fat percentage (right)	0.1	0.6	1.3	-1.1	0.3	0.5	1.0	-0.6	0.8
Trunk fat-free mass	0.1	0.4	0.8	-0.9	-0.8	0.7	0.3	-0.6	0.4
Hip circumference	0.6	2.7	7.2	-2.7	0.5	1.1	1.4	-1.7	1.7
Time employed in main current job	0.5	0.6	0.9	0.2	0.9	0.9	0.7	-0.8	0.8
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	-0.5	0.2	-0.7	0.5	-0.3
Father’s age at death	1.5	2.0	2.8	-1.4	1.3	1.7	0.8	-1.4	1.7
Worrier / anxious feelings	0.4	0.7	1.7	-0.4	-0.6	-1.0	-0.1	1.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	0.1	-0.8	-1.2	-0.9	1.3	-0.9
Falls in the last year	0.6	0.8	1.3	0.8	-1.2	0.1	-1.0	1.0	-0.9
Hair/balding pattern: Pattern 3	1.0	1.5	3.9	-2.0	1.1	0.8	0.7	-1.3	1.2
Number of live births	0.2	0.3	1.7	-1.3	-0.2	-0.1	-0.0	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1)	1.2	3.9	5.0	-0.7	-2.2	-2.2	-2.1	2.2	-1.9
Pulse rate	0.5	0.8	2.1	0.4	-0.9	-1.3	-1.4	0.3	-0.4
Happiness	0.5	0.6	1.4	-0.5	1.2	0.7	0.7	-0.1	0.8
Noisy workplace	0.2	0.2	0.8	-0.6	-0.9	-0.0	0.4	0.2	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.3	1.8	-0.5	0.4	-1.0	0.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.0	0.3	-1.4	-0.6	-0.8	0.4	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.4	0.1	0.7	0.3	-0.4	0.5
Asthma	2.0	3.9	5.8	-0.3	1.5	2.4	2.4	-2.2	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	-0.0	-1.0	-0.8	-0.4	0.6	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.6	1.2	0.3	-0.6	-0.7	0.9	-0.8
Depression (self-reported)	0.4	0.5	1.0	1.0	-0.3	-1.0	-0.1	0.9	-0.2
Medication: Lansoprazole	0.3	0.3	0.9	1.0	-0.7	-0.1	-0.2	0.1	-0.5
Prospective memory result	0.1	0.2	0.4	0.7	-0.1	-0.6	-0.3	0.3	0.0
Lung cancer (father)	0.3	0.3	1.6	1.2	0.0	-0.5	0.4	0.1	0.1
Illnesses of mother	0.1	0.1	0.3	0.5	-0.1	-0.3	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	5.5	0.0	-2.3	-2.0	-1.7	2.2	-2.0
Pulse wave Arterial Stiffness index	1.0	1.2	1.8	0.7	1.3	0.5	1.2	-1.2	1.3
Impedance of arm (left)	0.9	4.0	5.5	2.4	-1.1	-2.0	-1.6	2.3	-2.3
Arm fat mass (right)	0.2	0.8	2.4	-1.6	-0.0	0.3	1.1	-0.8	0.8
Trunk predicted mass	0.1	0.4	0.7	-0.8	-0.7	0.7	0.2	-0.6	0.4
Standing height	0.1	0.8	2.6	0.1	-1.6	-0.8	-0.4	0.5	-1.1
Length of working week for main job	0.2	0.2	0.3	0.6	-0.3	0.6	-0.5	-0.1	0.6
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.3	0.5	-0.1	-0.4	0.1	-0.1
Breastfed as a baby	0.8	1.0	2.1	-0.6	0.8	0.6	1.1	-1.5	1.2
Tense / ‘highly strung’	0.4	0.6	3.0	-1.7	0.6	0.1	-0.1	0.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.4	0.6	1.4	0.7	1.5	-0.7	0.9
Hair/balding pattern: Pattern 4	0.1	0.4	0.9	0.2	0.2	0.1	-0.9	0.9	-0.6
Birth weight of first child	0.8	1.5	4.7	-2.2	1.3	0.4	0.7	-0.9	1.0
Peak expiratory flow (PEF)	1.0	2.3	4.3	-0.6	-1.3	-1.4	-2.1	1.8	-1.4
Pulse wave reflection index	0.9	1.1	2.0	-0.5	1.4	0.9	1.0	-1.1	1.3
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.1	-0.3	-1.0	-1.5	-1.8	1.2	-1.3
Loud music exposure frequency	0.2	0.3	0.4	-0.2	-0.6	-0.6	-0.4	0.5	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	0.1	-0.1	-0.9	-0.5	0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.4	-0.4	0.6	1.4	1.6	-1.2	1.2
Blood clot in the leg (DVT)	1.6	2.1	3.0	-1.7	0.8	1.7	1.7	-1.2	1.4
Medication: Paracetamol	0.4	0.6	3.7	-1.9	0.1	-0.2	0.0	0.1	-0.1
Headache pain in last month	0.2	0.3	0.8	-0.6	-0.0	0.1	0.0	0.9	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.6	-1.3	-0.5	-0.3	0.0	0.3	-0.1
Glaucoma (self-reported)	0.1	0.1	0.2	0.3	-0.0	-0.3	0.2	0.5	-0.4
Gout (self-reported)	0.3	0.3	0.9	0.8	-0.2	0.3	1.0	-0.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.2	1.1	-0.8	-0.6	-0.7	-0.0	-0.4
Medication: Amlodipine	0.3	0.4	2.3	1.5	-0.3	-0.1	0.1	-0.2	-0.1
Medication: Ventolin 100micrograms inhaler	2.5	3.2	4.9	-1.6	1.2	1.8	2.0	-2.2	1.7
Birth weight	0.1	0.2	0.5	-0.7	-0.4	-0.2	-0.0	0.5	-0.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.0	-0.3	0.3	1.3	1.7	-1.2	0.8
High blood pressure (siblings)	0.3	0.4	0.7	-0.8	0.8	0.4	-0.2	-0.4	0.7
Forced vital capacity (FVC), Best measure	0.8	2.8	5.5	0.1	-2.4	-1.8	-1.0	1.9	-1.8
Body fat percentage	0.1	0.3	0.9	-1.0	-0.1	0.1	0.8	-0.4	0.5
Leg fat percentage (right)	0.5	1.8	3.2	-1.8	0.5	1.1	1.5	-1.4	1.4
Arm fat-free mass (right)	0.1	0.5	1.5	-1.2	-0.8	0.3	0.1	-0.5	0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.4	0.2	-0.5	-0.4	-0.0	0.3
Comparative body size at age 10	0.1	0.2	0.5	0.5	0.4	0.4	0.7	-0.3	0.6
Number of full brothers	1.2	1.5	2.8	0.9	-1.7	-0.6	-1.5	0.9	-1.4
Worry too long after embarrassment	0.3	0.5	1.1	0.4	-0.2	-0.5	-0.9	1.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.2	0.1	-0.1	0.1	-0.2	0.5	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.5	-0.1	-1.2	0.3	-0.1	0.3	-0.7
Number of children fathered	2.8	3.1	5.6	2.4	-1.5	-0.9	-1.5	1.8	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.1	-0.6	-0.7	0.0	-0.2	-0.3
Age at first live birth	0.2	0.4	1.2	0.3	-0.4	-0.0	-1.1	1.0	-0.3
Pulse wave peak to peak time	1.2	1.4	2.4	-0.5	-1.6	-0.5	-1.3	1.3	-1.4
Health satisfaction	0.3	0.4	0.9	-1.0	-0.2	-0.3	-0.9	0.6	-0.2
Shortness of breath walking on level ground	0.8	0.9	1.9	1.4	-1.1	-1.2	-0.4	0.7	-0.6
Qualifications: College or University degree	0.3	0.8	2.2	1.4	0.4	1.5	-0.7	-0.1	0.1
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.4	0.1	0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.3	0.7	0.6	-0.6	-0.4	0.3
Emphysema/chronic bronchitis	0.8	0.9	1.8	1.3	1.0	0.6	1.3	-0.6	0.6
Medication for pain relief, constipation, heartburn	0.4	0.6	1.5	0.4	0.7	0.9	0.6	-0.8	1.2
Neck or shoulder pain in last month	0.8	1.1	1.7	-0.5	-1.2	-1.3	-0.8	1.1	-1.3
Medication: Blood pressure	0.2	0.3	1.5	1.2	0.2	0.0	-0.0	-0.3	0.2
Angina (self-reported)	0.0	0.1	0.1	-0.3	-0.4	0.1	-0.2	-0.3	-0.2
Migraine (self-reported)	0.8	1.0	2.3	0.8	-0.8	-0.7	-0.9	1.5	-1.2
Medication: Ibuprofen	0.6	0.7	1.2	-0.6	-1.1	-1.0	-0.7	0.6	-1.0
Medication: Allopurinol	0.2	0.3	1.5	1.2	-0.1	-0.3	0.0	-0.1	-0.1
Medication: Omeprazole	0.2	0.2	0.8	-0.2	-0.4	-0.0	-0.3	0.9	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	3.0	-1.7	-0.4	-0.4	-0.2	0.3	-0.1
Mean time to correctly identify matches	0.4	0.7	2.5	1.6	-0.4	-0.7	-0.6	0.6	-0.5
Heart disease (mother)	0.3	0.4	1.1	-0.0	-1.0	-0.8	0.4	0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	-0.1	0.9	0.4	1.4	-1.0	0.9
Whole body fat mass	0.1	0.4	1.5	-1.2	-0.3	0.0	0.7	-0.5	0.5
Leg fat mass (right)	0.3	1.1	3.1	-1.8	-0.1	0.4	1.1	-1.0	1.0
Arm predicted mass (right)	0.1	0.6	1.8	-1.4	-0.5	0.5	0.4	-0.8	0.7
Pulse rate, automated reading	0.4	1.2	1.9	0.8	-1.3	-1.4	-1.0	0.4	-1.3
Alcohol intake frequency.	0.0	0.1	0.2	-0.3	0.3	0.3	0.1	-0.4	0.5
Comparative height size at age 10	0.1	0.8	1.6	1.1	-1.2	-0.6	-0.2	0.6	-1.0
Number of full sisters	0.5	0.6	1.9	1.4	-0.7	-0.6	-0.5	0.5	-0.4
Suffer from ‘nerves’	1.3	2.0	6.0	-2.4	1.8	1.0	0.6	-0.3	1.2
Overall health rating	0.0	0.1	0.4	-0.2	0.2	-0.6	-0.3	-0.0	-0.0
Chest pain or discomfort	0.1	0.1	0.7	-0.8	0.2	-0.1	0.1	0.0	0.4
Had major operations	0.6	0.7	1.0	-1.0	-0.4	0.9	1.0	-0.9	0.6
Age at last live birth	0.2	0.2	0.6	-0.3	-0.4	-0.0	-0.8	0.7	-0.2
Family relationship satisfaction	0.1	0.1	0.5	-0.2	0.7	0.4	-0.1	0.2	0.3
Leg pain on walking	0.1	0.2	0.3	0.3	-0.6	0.2	-0.3	0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.6	-0.5	-0.5	-0.0	0.5	-0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	-0.6	0.8	0.6	0.8	-0.9	1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.5	0.7	-0.5	-0.4	0.6	0.7	-0.4
Medication: Aspirin	0.8	1.0	1.6	1.1	-0.4	-1.0	-1.2	0.9	-1.3
Supplements: Vitamin C	0.1	0.1	0.3	-0.2	0.0	0.1	0.6	-0.3	0.5
Knee pain experienced in last month	3.1	4.8	6.3	1.9	-2.5	-1.6	-2.1	2.5	-2.3
Hypertension (Self-reported)	0.1	0.4	1.1	1.1	-0.1	-0.7	-0.4	0.3	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.1	0.6	-1.0	-1.0	-0.8	0.9	-0.5
Illnesses of father: Heart disease	0.1	0.1	0.5	0.4	0.7	0.2	-0.5	0.0	-0.0
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.4	1.1	0.9	0.1	-0.7	0.7
Smoking status: Previous	0.8	1.2	3.4	1.3	-0.5	-0.5	-1.8	1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.7	0.5	-0.1	0.5	1.3	-0.9	0.3
Whole body fat-free mass	0.1	0.3	0.9	-0.9	-0.8	0.3	0.2	-0.4	0.3
Leg fat-free mass (right)	0.0	0.2	0.8	-0.6	-0.9	-0.5	0.0	0.1	0.0
Arm fat percentage (left)	0.1	0.5	1.5	-1.2	0.2	0.4	0.7	-0.4	0.6
Average weekly red wine intake	0.1	0.2	0.4	-0.1	0.6	0.5	-0.7	-0.2	0.2
Handedness (chirality/laterality): Left-handed	1.1	1.4	2.4	-0.5	1.5	0.7	1.2	-1.1	1.5
Mood swings	0.2	0.4	1.7	-1.3	0.7	-0.1	0.1	0.5	0.2
Loneliness, isolation	0.3	0.5	1.0	-0.7	1.0	0.8	0.3	-0.3	0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.5	0.7	0.2	-0.1	0.3	0.1	-0.1
Ever had bowel cancer screening	0.3	0.4	1.4	1.2	0.4	0.9	0.1	0.1	-0.2
Diabetes diagnosed by doctor	0.9	1.4	6.7	1.1	2.6	-0.1	-0.3	-0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.1	-2.0	1.7	1.0	1.1	-1.0	1.1
Friendships satisfaction	1.2	1.5	3.3	-1.8	1.8	1.2	0.4	-0.4	0.9
Qualifications: nursing, teaching	0.1	0.2	0.4	0.6	-0.1	0.3	-0.5	0.4	-0.6
Commuting to job workplace: Walk	0.4	0.4	1.6	-0.6	-0.0	1.3	-0.4	-0.4	0.3
Eye problems/disorders: Cataract	0.1	0.2	0.6	-0.2	0.2	0.1	0.8	-0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	3.3	5.3	7.8	0.6	-2.2	-2.8	-2.4	2.7	-2.5
Medication for cholesterol	0.3	0.5	2.2	1.5	-0.0	0.4	-0.4	-0.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.7	-1.4	0.5	1.7	0.7	-1.0	0.6
Back pain experienced in last month	0.2	0.3	0.9	-0.7	1.0	0.2	-0.3	-0.3	0.3
Mineral and other dietary supplements	0.2	0.3	0.9	0.2	-0.1	-0.9	-0.8	0.3	-0.3
Breast cancer (self-reported)	0.3	0.4	1.0	0.3	0.2	0.6	1.0	-0.6	0.6
Asthma (self-reported)	2.0	4.0	5.8	-0.0	1.8	2.4	2.4	-2.2	2.1
Osteoporosis (self-reported)	1.2	1.4	2.4	-1.3	0.1	1.4	1.6	-1.2	1.0
Osteoarthritis (self-reported)	0.5	0.6	2.2	-0.0	1.0	0.6	1.5	-0.4	0.5
Medication: Aspirin	0.7	0.9	1.8	0.9	-0.3	-0.9	-1.4	0.9	-1.1
Medication: Gliclazide	3.2	3.6	7.8	0.3	2.8	1.1	2.2	-1.8	2.1
Illnesses of father: None of the above (group 1)	0.1	0.2	0.7	-0.0	-0.3	0.1	0.8	-0.3	0.4
Smoking status: Current	0.2	0.3	0.7	0.1	0.5	0.2	0.8	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	5.4	0.3	-1.9	-2.1	-1.8	2.3	-1.9
Whole body water mass	0.1	0.4	1.1	-1.0	-0.6	0.4	0.2	-0.5	0.4
Leg predicted mass (right)	0.0	0.2	0.7	-0.6	-0.8	-0.4	0.0	0.1	0.1
Arm fat mass (left)	0.2	0.7	3.1	-1.7	-0.2	0.3	0.8	-0.6	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	3.9	2.0	-0.4	-0.5	0.1	0.9	-0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.5	-0.3	-1.2	-0.9	-0.0	0.7	-0.7
Miserableness	0.1	0.3	0.7	-0.8	0.7	0.2	0.5	0.1	0.3
Guilty feelings	0.7	1.0	1.8	1.0	0.7	-1.0	-1.2	1.3	-0.6
Wears glasses or contact lenses	0.1	0.1	0.4	-0.2	-0.4	-0.6	0.1	0.1	-0.5
Ever taken oral contraceptive pill	0.6	0.6	1.3	-0.5	-1.1	-1.0	-0.3	0.7	-0.8
Hearing aid user	0.5	0.6	0.9	-0.7	0.5	0.8	0.6	-1.0	1.0
Mother’s age at death	0.1	0.2	0.4	0.6	0.2	0.2	-0.3	0.5	-0.2
Financial situation satisfaction	0.5	0.7	1.2	-0.8	0.7	0.6	1.1	-0.6	1.0
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.1	-0.4	0.0	1.0	-0.1	0.2	-0.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.2	-0.7	-1.1	-0.8	0.9	-1.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	1.2	-0.2	-0.6	-0.3	1.0	-0.8
Medication: Blood pressure	0.2	0.4	0.8	0.9	-0.1	-0.9	0.2	0.4	-0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	0.5	-0.1	-0.1	-0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.6	0.2	0.5	0.8	0.2	-0.2	0.2
High cholesterol (Self-reported)	0.2	0.3	1.0	1.0	0.4	0.7	-0.0	0.5	-0.4
Medication: Bendroflumethiazide	0.4	0.7	1.3	0.7	-0.6	-0.7	-1.1	0.7	-1.0
Medication: Paracetamol	0.5	0.8	3.6	-1.9	0.8	0.1	0.0	-0.2	0.5
Medication: Lisinopril	1.5	1.9	2.7	-1.2	1.3	1.4	1.6	-1.5	1.1
Medication: Atorvastatin	0.6	0.7	1.6	1.3	-0.3	-0.8	-0.7	1.0	-0.6
Illnesses of father: High blood pressure	0.4	0.5	1.8	-1.4	0.7	0.5	-0.4	-0.1	0.6
Alcohol drinker status: Never	0.9	1.0	2.5	-0.1	0.9	1.6	1.1	-0.9	0.9
Ever smoked	1.6	2.8	7.5	2.7	-0.5	-1.0	-2.4	1.2	-0.8
Basal metabolic rate	0.1	0.4	1.2	-1.1	-0.6	0.3	0.5	-0.6	0.5
Leg fat percentage (left)	0.4	1.4	2.9	-1.7	0.3	0.7	1.3	-1.2	1.2
Arm fat-free mass (left)	0.1	0.7	1.8	-1.3	-0.7	0.4	0.6	-0.8	0.7
Number of operations (self-reported)	0.1	0.2	0.3	-0.2	-0.6	-0.4	-0.2	0.5	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.8	0.9	-0.0	-0.4	0.3	0.5	-0.1
Irritability	0.2	0.3	1.0	-0.1	0.4	-1.0	-0.4	0.7	-0.1
Risk taking	0.1	0.2	0.5	-0.6	0.2	0.7	-0.4	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.0	1.0	0.6	-0.8	-0.5	0.7
Fractured/broken bones in last 5 years	0.7	1.0	3.1	-1.2	-1.8	-0.9	0.3	0.3	-0.4
Age started oral contraceptive pill	0.6	0.7	1.0	1.0	-0.8	-0.7	-0.6	0.9	-0.9
Diastolic blood pressure, automated reading	1.6	5.1	10.7	1.1	-2.5	-3.3	-1.7	2.3	-2.1
Ever depressed for a whole week	0.6	0.8	1.6	1.2	1.0	0.6	1.2	-0.2	0.2
Unable to work because of sickness or disability	0.4	0.5	0.9	0.9	0.9	0.3	0.8	-0.6	0.5
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.0	0.9	1.1	0.6	-0.4	0.8
Myopia	0.6	0.9	1.5	-1.1	0.9	0.8	1.2	-0.7	0.8
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.6	-1.2	0.2	0.5	0.8	-0.3	0.7
Cholesterol lowering medication	0.3	0.5	1.0	-0.5	-0.6	-0.6	0.5	1.0	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.2	-0.8	-0.6	-0.5	1.1	-0.9
Pain experienced in last month	0.6	1.0	2.2	-0.5	0.6	1.1	0.8	-1.5	1.2
Supplements: Calcium	2.3	2.6	4.0	-1.5	1.2	1.9	1.2	-2.0	1.6
Basal cell carcinoma (self-reported)	1.3	1.6	2.2	-1.3	0.9	1.1	1.5	-1.4	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.2	-0.2	-0.7	-1.1	-1.1	0.7	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.1	-1.4	0.4	1.2	1.4	-0.8	1.0
Heart disease (siblings)	0.2	0.2	0.4	-0.4	0.1	0.2	-0.5	0.6	-0.6
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.2	0.4	-0.1	-0.4	0.1	0.5
Pack years of smoking	0.6	0.8	3.3	-0.1	-1.8	-0.7	0.6	0.3	-0.9
Impedance of whole body	0.4	2.1	3.8	1.9	-0.8	-1.4	-1.2	1.5	-1.6
Leg fat mass (left)	0.2	0.8	2.7	-1.6	-0.3	0.1	0.9	-0.7	0.8
Arm predicted mass (left)	0.2	0.9	1.9	-1.4	-0.3	0.8	0.9	-1.1	1.0