Hub : Genes

METTL13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.23 0.042 0.0e+00 0.234 0.244 0.245 0.274 0.270 4.5e-28 2.3e-29 1.6e-29 2.0e-33 8.0e-33
2 GTEx Brain Cerebellar Hemisphere 0.20 0.076 7.0e-03 0.180 NA 0.190 NA 0.157 2.2e-05 NA 1.3e-05 NA 7.7e-05
3 GTEx Brain Cerebellum 0.22 0.082 3.7e-03 -0.002 NA 0.048 NA 0.015 3.8e-01 NA 1.5e-02 NA 1.1e-01
4 GTEx Cells EBV-transformed lymphocytes 0.35 0.113 4.2e-03 0.000 NA 0.033 NA 0.023 3.3e-01 NA 3.0e-02 NA 5.9e-02
5 GTEx Esophagus Mucosa 0.09 0.042 4.5e-03 0.003 NA -0.004 NA -0.002 1.9e-01 NA 6.9e-01 NA 5.0e-01
6 GTEx Skin Sun Exposed Lower leg 0.11 0.033 2.2e-06 0.079 NA 0.122 NA 0.128 4.3e-07 NA 2.6e-10 NA 9.9e-11
7 GTEx Testis 0.29 0.088 6.8e-05 0.046 NA 0.030 NA 0.088 4.3e-03 NA 1.8e-02 NA 9.9e-05
8 METSIM Adipose 0.06 0.020 2.7e-06 0.047 0.042 0.037 0.042 0.039 1.2e-07 5.7e-07 2.4e-06 6.5e-07 1.4e-06
9 YFS Blood 0.11 0.021 0.0e+00 0.101 0.095 0.104 0.105 0.103 2.1e-31 1.7e-29 4.2e-32 1.5e-32 6.1e-32
10 TCGA Breast Normal 0.01 0.007 8.9e-03 0.007 0.002 0.007 0.004 0.008 4.3e-03 6.1e-02 4.1e-03 2.5e-02 1.8e-03
11 TCGA Prostate Tumor 0.02 0.012 7.8e-03 0.023 0.013 0.008 NA 0.012 4.9e-04 8.3e-03 3.1e-02 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Alzheimer’s Disease (in mother) 0.9 1.1 3.8 1.0 -1.1 0.8 0.3 1.9 1.3 0.0 0.8 -0.6 -0.8 -1.3
Alzheimer’s Disease (in father) 0.2 0.2 0.8 0.4 -0.4 -0.9 0.1 0.2 0.4 0.4 0.8 -0.3 -0.4 0.5
Alzheimer’s Disease (including proxy) 0.9 1.3 3.7 1.3 -1.4 -0.4 0.4 1.9 1.7 0.2 1.0 -0.9 -0.9 -0.9
Crohns Disease (2017) 0.1 0.2 0.5 -0.6 0.5 -0.7 0.6 -0.4 -0.2 -0.0 -0.0 0.4 -0.2 -0.4
Irritable Bowel Disease (IBD) 0.2 0.5 2.0 -0.8 -0.0 -0.9 0.5 0.2 0.6 -0.3 0.3 -0.2 -0.9 -1.4
Ulcerative Colitis (UC) 0.4 0.8 3.2 -0.7 -0.4 -0.6 0.1 0.5 1.2 -0.4 0.5 -0.6 -1.5 -1.8
Major Depression (MDD) 0.8 0.9 3.3 0.2 0.2 1.6 0.6 -0.1 -1.0 1.8 -1.2 0.2 1.0 0.8
Reaction Time 0.3 0.7 2.9 -0.2 0.1 1.7 1.1 0.1 0.4 -0.6 0.0 0.5 -1.2 -1.0
Verbal and Numeric Reasoning (VNR) 6.2 15.1 27.5 5.2 -5.0 -5.2 -3.8 3.7 3.5 4.1 1.6 -5.2 0.9 0.5
Breast Cancer 0.6 1.4 5.4 1.4 -0.2 0.9 -1.7 -0.4 -1.0 1.0 -0.7 -0.1 1.3 2.3
Ovarian Cancer 2.9 3.9 7.2 -2.3 2.4 1.9 -0.0 -2.7 -2.1 -1.3 -1.9 2.3 1.3 2.0
Prostate Cancer 1.1 1.6 3.3 1.8 -1.5 -0.1 -1.7 1.8 1.0 1.3 0.4 -1.1 -1.2 -0.1
Age at First Birth 0.7 1.0 5.4 -0.9 0.8 0.3 0.2 -0.5 -0.3 -0.7 1.4 1.1 2.3 0.6
Bipolar Disorder 0.2 0.2 0.9 -0.7 0.3 0.0 0.9 -0.0 0.1 -0.6 0.1 0.3 -0.6 -0.5
Body Mass Index (BMI) (2010) 1.0 1.3 2.2 1.1 -1.5 -0.4 0.3 1.4 1.4 0.9 0.4 -1.4 -1.5 -1.4
Coronary Artery Disease (CAD) 0.6 0.7 5.7 0.2 0.2 2.4 -0.6 0.1 -0.6 -0.1 -1.0 0.2 -0.4 0.3
Crohns Disease (2012) 0.2 0.3 0.8 -0.4 0.5 0.3 -0.5 -0.6 -0.8 0.1 -0.6 0.4 0.3 0.9
Mean Putamen Volume 1.3 1.5 2.8 -1.5 1.6 1.3 0.3 -1.6 -1.2 -1.5 -0.4 1.7 -0.1 0.1
Fasting Glucose 0.2 0.2 0.8 -0.6 0.5 0.2 0.4 -0.4 -0.6 -0.0 -0.3 0.3 0.1 -0.9
HbA1C 0.5 0.5 2.6 -0.0 0.1 0.6 -0.3 -0.5 -0.6 -0.0 -0.3 0.3 1.6 1.3
HDL Cholesterol 1.1 1.9 3.6 1.1 -1.3 -1.9 -1.4 1.7 1.5 0.4 0.7 -1.6 -1.1 -1.6
LDL Cholesterol 0.6 1.0 2.6 1.3 -1.2 -0.4 -1.6 1.4 0.8 0.3 -0.2 -0.9 -1.1 -0.3
Lupus 0.5 0.7 2.6 -0.6 0.8 -0.7 0.8 -0.9 -0.9 0.5 -1.1 0.4 1.6 0.3
Neuroticism 2.0 2.9 7.0 -1.3 1.8 2.4 0.5 -1.8 -2.5 1.1 -2.6 1.5 0.4 1.3
Primary Biliary Cirrhosis 1.4 1.9 4.3 1.3 -1.6 -1.1 0.2 1.6 1.9 0.8 0.7 -1.6 -2.1 -1.4
Rheumatoid Arthritis 1.0 1.4 8.2 -1.4 0.9 0.1 -0.3 -0.6 0.2 -2.9 0.6 1.0 -1.3 -1.2
Schizophrenia 1.1 2.4 6.5 -1.8 2.0 0.9 2.5 -2.2 -1.4 -0.5 0.4 2.0 -0.1 0.7
Triglycerides 0.4 0.6 1.6 -0.5 0.7 1.1 -0.5 -0.7 -1.0 -0.3 -1.3 0.6 0.5 1.0
Type 2 Diabetes (T2D) 0.2 0.3 1.1 0.5 -0.3 0.3 -0.7 0.8 0.0 1.1 -0.6 -0.1 -0.3 0.0
Ulcerative Colitis 0.1 0.1 0.5 0.4 0.1 0.5 0.4 -0.1 0.0 -0.5 0.7 0.4 0.2 -0.0
Blood Eosinophil Count 0.4 3.6 8.9 3.0 -1.7 -1.7 -2.7 0.8 0.8 2.5 -0.1 -2.3 -1.9 -0.4
Blood Platelet Count 8.3 96.5 210.2 4.8 -9.7 -5.4 -1.2 12.0 14.0 -8.6 14.5 -7.5 -7.7 -13.2
Blood Red Count 1.2 11.5 23.8 -4.1 3.9 4.9 3.0 -3.3 -3.2 -3.9 -1.2 4.7 1.2 0.5
Blood White Count 0.1 0.6 1.5 -0.5 0.7 1.2 -0.1 -0.6 -0.8 -0.8 -1.2 0.7 -0.7 -0.4
Heel T-Score 0.4 3.4 19.5 -1.4 1.6 -2.2 4.4 -1.4 -0.9 1.9 -0.3 0.7 -0.5 -1.4
BMI 0.7 3.9 27.4 -0.2 0.6 2.5 -1.6 -0.8 -1.4 1.1 -5.2 -0.2 -1.4 0.6
Height 2.4 47.7 240.2 7.1 -3.5 -9.8 -4.1 0.2 -0.9 15.5 -4.5 -6.4 3.4 6.0
Waist Hip Ratio (WHR) 0.3 1.6 3.6 -0.9 1.1 1.9 0.5 -1.2 -1.1 -0.6 0.1 1.8 1.7 1.5
Systolic Blood Pressure 0.7 3.7 9.2 2.2 -2.1 -3.0 -1.3 1.8 1.2 2.3 -0.7 -2.6 -1.5 -1.0
Smoking Status 1.3 3.1 7.7 -0.2 1.2 1.4 -0.6 -1.1 -2.3 1.9 -2.8 1.1 2.0 2.8
Allergy or Eczema 0.9 2.4 6.2 1.8 -1.9 -0.5 0.1 2.5 2.0 2.1 1.8 -1.2 -0.3 -0.4
Cardiovascular Disease 0.9 2.8 9.6 1.4 -1.1 -2.0 -1.6 0.7 0.2 2.3 -3.1 -1.9 -1.3 -0.3
Hypothyroidism (self reported) 0.6 1.3 3.4 -1.5 1.5 1.2 1.9 -1.4 -0.9 -0.3 -0.5 1.1 -0.9 -0.6
Respiratory disease 0.3 0.7 1.4 0.9 -0.5 -0.6 -1.2 0.3 -0.1 1.0 -1.2 -0.5 1.2 1.0
Type 2 Diabetes (T2D) 0.8 1.6 8.1 -0.1 -0.5 0.3 0.3 0.7 1.5 -0.3 -0.3 -0.9 -2.8 -2.2
Lung FEV1/FVC ratio 0.5 2.7 7.3 2.7 -1.9 0.3 -0.0 1.5 0.4 2.3 -0.9 -1.6 0.6 2.5
Lung FVC 0.3 1.5 6.4 -0.5 -0.1 -0.4 2.5 0.6 1.0 -1.5 1.4 0.1 -0.7 -1.9
Neuroticism 6.9 16.9 42.4 -4.4 4.8 6.5 4.9 -4.4 -4.5 -0.2 -1.4 5.1 1.8 2.5
Chronotype (morning person) 0.9 2.0 4.3 -0.3 1.1 2.1 0.7 -1.1 -1.9 1.7 -2.1 1.2 0.2 1.7
Hair Pigment 0.1 3.4 11.9 -2.3 1.6 3.5 2.5 -0.8 -0.6 -2.4 0.6 2.0 0.3 -0.5
Tanning 0.2 2.1 5.2 -0.5 1.2 1.6 -0.1 -1.2 -1.7 0.1 -1.4 1.5 2.2 2.3
Hand grip strength (left) 0.2 0.5 1.5 -0.5 0.6 0.9 0.5 -0.2 -0.7 -0.3 0.8 1.2 0.7 -0.3
Number of treatments/medications taken 0.2 0.4 1.2 0.1 -0.0 -0.9 -1.1 -0.0 -0.4 -0.7 -0.2 -0.3 0.9 1.0
Average weekly spirits intake 1.3 1.6 5.1 0.7 -1.1 -1.1 0.2 1.4 1.4 -0.8 2.3 -1.1 -1.4 -1.3
Sensitivity / hurt feelings 4.3 7.5 24.4 2.8 -3.2 -4.9 -2.0 3.0 2.9 0.5 1.1 -3.5 -0.8 -2.1
Frequency of depressed mood in last 2 weeks 1.0 1.4 4.8 0.8 -1.0 -2.2 -1.6 1.0 1.2 -1.0 1.2 -1.0 0.0 -0.6
Hearing difficulty/problems: Yes 0.8 1.2 2.3 1.3 -1.3 -1.0 -1.3 1.3 0.6 1.3 0.2 -1.1 1.5 0.4
Relative age of first facial hair 0.4 0.9 3.4 -0.9 1.0 0.9 0.5 -0.9 -1.1 0.0 -1.8 0.8 0.6 -0.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 3.5 -0.4 0.8 1.9 0.2 -1.1 -1.0 0.6 0.6 0.9 1.6 1.1
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.0 0.5 -0.4 0.6 -1.0 0.8 0.4 -0.4 -0.0 0.3 -0.8 0.1
Ever had hysterectomy (womb removed) 0.5 0.6 3.9 0.5 -0.6 -0.0 -2.0 0.9 0.6 -0.5 0.6 -0.3 -0.3 -0.1
Systolic blood pressure, automated reading 0.1 0.3 1.1 -0.3 0.3 0.9 -0.6 -0.1 -0.2 -1.1 0.1 0.4 -0.0 0.2
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 4.4 0.4 0.5 -0.5 -0.7 -1.1 -1.7 1.9 -1.1 0.2 1.9 2.1
Angina 0.2 0.3 1.6 0.2 -0.3 -0.3 -0.2 -0.2 0.3 -0.2 0.8 -0.3 1.3 0.5
Medication for hormone replacement therapy 0.3 0.3 0.9 0.9 -0.8 0.1 -0.9 0.3 0.7 0.2 0.2 -0.6 0.3 0.4
Vitamin and mineral supplements 0.6 0.8 1.9 -0.6 1.0 1.4 1.1 -0.7 -0.9 0.5 -0.4 1.4 0.9 0.4
Supplements: Zinc 2.0 2.2 8.2 -1.0 -0.0 -0.1 1.3 0.4 1.2 -2.0 2.0 -0.2 -1.9 -2.9
Medication: Co-codamol 1.6 1.8 3.5 1.9 -1.7 -1.0 -0.5 1.9 1.2 1.9 0.9 -1.7 0.2 -0.5
Medication: Metformin 0.9 1.2 3.7 -0.8 1.1 0.4 0.7 -0.9 -1.5 -0.4 0.1 1.3 1.9 1.6
Diabetes (father) 0.8 1.0 2.0 1.4 -0.9 0.2 0.4 1.3 0.5 1.4 0.8 -0.5 1.3 1.3
Diabetes (mother) 0.9 1.1 6.3 1.6 -0.8 -0.5 -0.5 0.6 -0.1 2.5 -0.7 -0.8 0.0 0.8
Severe depression (siblings) 0.7 0.8 2.2 0.4 -0.7 -1.3 0.0 1.1 0.9 -0.6 0.9 -0.8 -0.8 -1.5
Pack years adult smoking proportion 0.6 0.9 4.3 0.3 -0.6 0.0 0.1 0.8 1.1 -1.0 1.2 -0.3 -2.1 -0.8
Impedance of leg (right) 0.3 1.7 6.8 1.1 -1.2 0.2 -1.8 1.4 1.0 0.5 -1.2 -1.1 -2.6 -0.2
Leg fat-free mass (left) 1.4 7.5 34.0 -2.5 1.2 2.3 3.1 -0.1 0.6 -5.8 3.5 2.3 1.2 -2.5
Trunk fat percentage 0.6 2.5 10.9 0.8 -1.2 -0.5 1.0 1.8 2.0 -1.7 3.3 -0.4 -0.9 -1.4
Hand grip strength (right) 0.5 1.5 3.6 -1.5 1.4 0.9 1.5 -1.0 -1.0 -1.2 0.7 1.9 1.1 -0.2
Townsend deprivation index at recruitment 0.5 0.6 1.8 0.4 -0.6 -1.2 -1.3 0.0 0.7 -0.5 1.1 -1.1 -0.4 -0.4
Current tobacco smoking 0.5 0.8 2.4 -0.6 0.0 -0.5 0.6 0.0 0.7 -1.3 1.0 0.0 -1.5 -1.3
Average weekly fortified wine intake 0.4 0.5 3.0 0.5 -0.4 0.1 -0.8 0.5 -0.3 1.7 -0.5 -0.2 0.9 0.5
Maternal smoking around birth 2.3 3.3 7.5 2.7 -2.3 -1.2 -0.9 2.1 1.5 2.7 1.6 -2.0 0.2 0.0
Fed-up feelings 3.1 5.7 14.4 1.0 -2.1 -3.8 -1.0 2.5 3.1 -2.0 3.0 -2.0 -1.1 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 11.2 1.7 -2.1 -3.3 -1.8 2.0 2.1 -0.8 0.9 -2.0 -1.5 -1.1
Relative age voice broke 0.7 1.1 2.6 -0.6 1.2 0.8 0.1 -1.3 -1.5 0.8 -1.6 0.8 1.2 0.4
Taking other prescription medications 0.4 0.6 2.5 0.6 -0.2 -0.8 -1.2 0.1 -0.6 -0.1 -0.7 -0.2 0.9 1.6
Age when periods started (menarche) 1.2 3.0 7.1 -1.9 2.3 2.7 1.4 -1.9 -2.0 0.2 -0.5 2.3 1.0 0.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.8 -0.4 -0.2 0.4 -0.9 -0.1 0.3 -0.9 -0.1 -0.3 0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.5 1.3 -1.6 -0.3 -1.9 1.6 1.6 -0.8 1.5 -0.9 0.5 0.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.1 1.1 -1.0 -0.8 -0.0 0.3 0.6 1.5 -0.8 -1.0 -0.3 -0.0
Qualifications: CSEs or equivalent 1.0 1.3 7.1 0.7 -0.6 -1.6 1.1 0.3 0.6 1.0 0.9 -0.7 2.7 0.1
Serious illness, injury or assault to yourself 0.4 0.4 1.8 0.6 -0.6 -0.3 -0.5 0.5 0.9 -1.4 0.7 -0.1 -0.5 0.1
High blood pressure 0.3 0.9 2.5 -0.1 0.2 1.6 0.1 -0.0 0.1 -1.6 1.5 0.9 1.3 0.7
Hayfever, allergic rhinitis or eczema 0.7 1.5 5.2 -1.5 1.4 1.1 0.2 -1.6 -1.2 -2.3 -0.9 1.2 0.3 0.0
Multivitamins +/- minerals 1.4 1.8 3.0 1.2 -1.6 -1.6 -1.0 1.5 1.7 -0.0 1.5 -1.7 -1.1 -0.9
Stomach or abdominal pain in last month 0.1 0.1 0.8 0.4 -0.2 -0.1 -0.1 0.2 0.1 -0.1 0.4 -0.3 0.9 -0.5
Supplements: Glucosamine 0.3 0.4 1.8 0.7 -0.5 0.9 0.1 0.7 0.4 0.7 0.1 -0.2 -1.4 -0.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 4.2 -0.7 0.7 2.1 0.7 -0.5 -0.6 -0.3 0.6 1.1 0.4 -0.1
Medication: Atenolol 0.7 0.9 2.2 -0.9 0.7 1.3 1.1 -0.5 0.1 -1.5 1.2 1.1 0.8 0.1
Medication: Levothyroxine sodium 0.7 1.3 4.3 1.5 -0.9 -0.2 -0.8 0.8 -0.2 1.5 -0.2 -0.5 2.1 1.6
Sitting height 2.2 15.7 92.7 -3.9 1.3 4.0 3.2 0.2 1.2 -9.6 3.1 2.8 -0.8 -4.2
Chronic bronchitis/emphysema (father) 0.3 0.3 2.0 0.0 0.1 0.4 0.4 -0.6 -0.4 0.4 -0.5 0.1 -1.4 -0.5
High blood pressure (mother) 0.3 0.4 1.7 0.3 0.1 0.2 -1.0 -0.1 -0.7 0.3 -0.8 0.1 1.3 0.9
Body mass index (BMI) 0.6 2.8 13.8 1.1 -1.3 -2.4 0.7 1.5 1.8 -0.4 3.7 -0.9 0.7 -1.0
Impedance of leg (left) 0.4 2.1 6.4 1.5 -1.6 -0.3 -1.8 1.5 1.2 1.1 -1.2 -1.7 -2.5 -0.3
Leg predicted mass (left) 1.4 7.6 34.7 -2.5 1.2 2.4 3.1 -0.1 0.6 -5.9 3.6 2.3 1.2 -2.5
Trunk fat mass 0.9 3.8 15.8 -0.0 -0.9 0.1 1.7 1.7 2.1 -3.3 4.0 0.1 -0.4 -2.1
Waist circumference 0.8 2.8 10.9 0.5 -1.1 -1.0 0.8 1.9 2.1 -2.0 3.3 -0.5 -0.1 -2.3
Number of incorrect matches in round 1.0 1.7 9.1 1.8 -0.9 -1.1 -3.0 0.6 0.0 0.3 -1.1 -0.7 -0.9 1.0
Past tobacco smoking 0.7 1.3 3.1 -1.3 1.5 1.8 0.8 -1.0 -1.2 -0.9 -0.9 1.6 0.4 0.6
Alcohol usually taken with meals 1.3 2.1 9.2 -0.5 1.2 3.0 0.9 -1.1 -1.6 1.1 -1.3 1.6 0.6 1.5
Nervous feelings 2.5 4.7 11.0 2.5 -2.5 -3.3 -2.5 2.2 2.0 0.8 -1.1 -2.9 -1.7 -0.3
Frequency of tenseness / restlessness in last 2 weeks 5.0 7.9 13.1 3.0 -3.6 -3.3 -3.4 3.4 3.5 -0.3 1.8 -3.4 -1.3 -1.5
Hearing difficulty/problems with background noise 1.0 1.7 3.7 1.3 -1.4 -1.7 -1.4 1.9 1.3 0.4 0.8 -1.3 -0.2 -1.2
Hair/balding pattern: Pattern 2 1.5 1.9 5.5 1.4 -0.6 -1.9 -1.2 0.0 -0.6 2.3 -0.9 -1.2 1.6 1.6
Had menopause 0.3 0.4 2.9 0.2 -0.2 0.2 -1.7 0.6 0.1 -0.8 0.1 -0.2 -0.6 -0.4
Had other major operations 0.5 0.6 2.1 0.1 -0.5 1.0 1.3 0.8 0.8 -1.4 0.5 0.1 -0.6 -0.1
Forced vital capacity (FVC) 1.1 4.2 14.8 -2.4 1.4 3.7 1.3 -0.9 -0.2 -3.9 1.1 2.2 -0.5 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 3.2 1.5 -1.6 -0.5 -1.8 1.5 1.4 -0.4 1.4 -1.1 0.9 0.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.2 -0.2 -0.2 -1.0 -0.1 0.3 0.1 -0.2 0.1 -0.3 1.1 0.3
Qualifications: None of the above 1.0 2.2 7.5 1.3 -1.2 -2.7 -1.5 1.0 1.2 -0.1 2.2 -1.6 -0.2 -1.0
Financial difficulties in last 2 years 1.0 1.4 5.7 0.0 -0.8 -0.3 0.3 1.0 1.6 -2.4 2.0 -0.4 -0.9 -0.9
Mouth/teeth dental problems 0.5 0.8 3.3 -0.1 -0.3 -0.2 1.4 0.8 1.0 -0.2 0.7 -0.3 -1.0 -1.8
Heart attack 1.0 1.3 5.2 -1.3 0.7 0.2 0.2 -0.1 0.2 -2.3 2.3 1.0 0.9 -0.5
Allergy 0.4 1.0 5.4 1.2 -1.0 -0.5 -0.1 1.2 0.5 2.3 0.2 -0.8 0.3 0.4
Pain all over the body in last month 1.8 1.9 4.2 -1.3 1.0 1.3 1.0 -0.3 0.3 -2.1 2.0 1.3 -1.2 -2.0
Diabetes (self-reported) 1.1 1.6 8.1 0.1 0.5 0.2 -1.2 -0.8 -1.7 0.4 -0.4 0.4 2.8 2.0
Hayfever/allergic rhinitis (self-reported) 3.7 4.8 8.0 -2.5 2.8 2.6 1.8 -2.7 -2.5 -2.1 -1.0 2.7 1.4 1.0
Medication: Ramipril 2.6 3.4 6.1 -1.7 2.0 2.0 1.2 -1.8 -1.9 -0.9 -0.6 2.5 2.4 2.2
Medication: Simvastatin 0.3 0.5 1.6 -0.4 0.4 0.0 0.6 -0.9 -0.7 -0.4 -0.2 0.4 1.3 1.2
Fluid intelligence score 5.6 11.8 23.1 -4.8 4.4 4.3 3.4 -3.7 -3.0 -3.8 -1.4 4.2 -1.1 -1.0
Illnesses of siblings 0.4 0.5 2.7 0.3 -0.0 0.5 -0.1 -0.3 -0.3 1.2 -1.6 -0.2 0.1 0.9
Neuroticism score 7.1 15.2 39.7 3.8 -4.5 -6.3 -4.2 4.4 4.6 -0.3 1.5 -4.7 -1.8 -2.8
Weight 1.2 6.0 26.4 -1.4 0.2 1.0 2.3 0.9 1.6 -5.1 4.3 1.3 0.3 -2.7
Impedance of arm (right) 0.4 2.0 7.1 -0.5 0.9 2.4 -0.8 -0.8 -1.3 0.5 -2.7 0.9 -1.4 1.4
Arm fat percentage (right) 0.5 2.1 10.8 0.9 -1.2 -1.8 0.8 1.5 1.7 -0.4 3.3 -0.6 0.0 -0.6
Trunk fat-free mass 1.5 8.6 45.4 -2.9 1.2 2.4 2.5 -0.1 0.8 -6.7 3.1 2.2 1.2 -3.3
Hip circumference 0.8 3.6 13.9 -1.0 0.2 1.5 1.8 0.6 1.2 -3.7 3.4 1.4 0.3 -1.8
Time employed in main current job 0.7 0.8 2.3 -1.1 0.9 -0.3 1.5 -1.1 -0.7 -0.2 -0.9 0.3 1.1 -0.5
Alcohol intake versus 10 years previously 0.8 1.2 2.8 0.9 -1.3 -1.1 -0.6 1.0 1.7 -1.3 1.2 -1.2 -1.1 -0.4
Father’s age at death 0.7 0.9 2.3 -0.2 0.8 1.5 -1.1 -1.0 -1.4 1.0 -1.0 0.6 -0.6 0.7
Worrier / anxious feelings 5.6 10.7 18.7 3.5 -4.2 -4.2 -2.3 4.2 4.3 -0.1 1.7 -4.1 -1.9 -2.3
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.9 3.9 1.6 -1.4 -2.0 -2.0 1.1 1.3 -0.2 1.7 -1.3 0.7 -0.1
Falls in the last year 2.7 3.7 8.5 -2.2 1.4 1.6 2.8 -0.3 0.4 -2.9 2.0 2.0 -1.3 -2.2
Hair/balding pattern: Pattern 3 0.6 0.9 2.8 -0.6 -0.4 0.7 1.1 0.3 1.1 -1.7 1.2 -0.6 -0.2 -1.1
Number of live births 0.7 0.9 4.6 0.8 -0.3 -0.1 -1.2 0.2 -0.5 0.8 -0.8 -0.3 2.1 1.4
Forced expiratory volume in 1-second (FEV1) 1.1 3.9 14.4 -2.7 1.6 2.7 1.2 -1.0 -0.2 -3.8 1.4 2.2 -0.1 -1.4
Pulse rate 1.8 3.1 8.7 -0.7 1.5 0.8 0.3 -2.2 -2.0 1.6 -2.2 1.1 2.0 3.0
Happiness 1.9 2.4 6.1 0.8 -1.5 -2.5 -0.8 1.6 2.1 -0.3 1.2 -1.6 -1.4 -1.8
Noisy workplace 3.7 4.6 9.3 3.0 -2.7 -3.1 -0.3 2.1 1.6 2.5 2.0 -2.7 0.4 -0.2
Qualifications: A levels/AS levels or equivalent 1.7 3.8 16.5 -2.3 1.9 4.1 1.9 -1.0 -1.1 -1.6 -1.0 2.3 -1.4 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.9 0.1 0.1 0.4 -1.3 -0.2 -0.8 0.9 -1.7 -0.2 -0.3 0.5
Mouth/teeth dental problems: Dentures 1.0 1.7 6.9 0.9 -0.1 0.0 -2.3 -0.4 -1.2 0.9 -1.1 -0.3 1.1 2.6
Asthma 0.7 1.3 2.8 -1.4 1.1 1.1 1.7 -0.8 -0.2 -1.6 1.3 1.1 -0.5 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.0 0.4 -0.0 -0.4 -1.4 -0.1 -0.3 0.1 -1.2 -0.4 -1.2 -0.3
Medication: Cholesterol lowering 0.3 0.4 2.1 0.5 -0.6 -0.3 0.8 0.4 0.6 -0.2 1.4 -0.3 0.3 -0.3
Depression (self-reported) 2.4 2.8 9.7 0.5 -1.3 -1.6 0.2 1.8 2.2 -1.1 2.1 -1.0 -1.5 -3.1
Medication: Lansoprazole 1.6 1.8 5.7 -0.5 1.1 0.3 -0.7 -1.7 -1.7 0.5 -1.7 0.8 1.7 2.4
Prospective memory result 2.8 3.4 9.3 3.1 -2.6 -1.4 -0.8 2.8 2.0 1.5 0.7 -1.7 -1.3 0.1
Lung cancer (father) 0.2 0.2 0.5 0.6 -0.7 -0.3 -0.7 0.3 0.4 0.4 0.1 -0.5 -0.5 0.2
Illnesses of mother 1.0 1.3 3.3 -0.7 -0.1 -0.5 1.0 0.2 1.3 -1.8 1.4 0.2 -1.8 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 9.8 -2.1 1.3 2.7 0.4 -0.7 -0.3 -3.1 0.9 2.0 0.4 -0.9
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 -1.0 0.8 0.2 0.9 -0.6 -0.6 -0.5 -0.9 0.7 -0.4 0.0
Impedance of arm (left) 0.6 2.7 9.3 -1.2 1.4 3.0 0.2 -1.2 -1.6 -0.0 -2.6 1.5 -1.7 1.2
Arm fat mass (right) 0.7 2.8 15.1 0.1 -0.8 -0.8 1.2 1.2 1.8 -2.4 3.9 -0.0 0.4 -1.5
Trunk predicted mass 1.5 8.6 44.5 -2.9 1.2 2.5 2.5 -0.1 0.8 -6.7 3.1 2.3 1.2 -3.3
Standing height 2.3 23.0 110.2 -5.3 2.9 7.1 3.7 -0.9 -0.1 -10.5 1.8 4.5 -0.9 -4.1
Length of working week for main job 0.9 0.9 2.1 0.9 -1.1 -0.7 0.9 1.2 1.4 -0.7 1.5 -0.7 0.0 -0.8
Exposure to tobacco smoke at home 0.3 0.4 1.3 0.7 -0.4 -1.1 -0.6 0.2 0.3 0.7 0.9 -0.5 0.1 -0.1
Breastfed as a baby 0.9 1.1 2.8 -1.2 0.9 1.4 1.2 -0.5 0.0 -1.6 0.3 1.7 -0.3 -0.3
Tense / ‘highly strung’ 5.3 8.9 14.8 3.2 -3.5 -3.9 -3.5 3.6 3.5 -0.4 0.5 -3.6 -2.6 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 6.1 0.9 -1.6 -1.8 1.2 1.9 2.5 -1.2 1.5 -0.8 -1.3 -1.4
Hair/balding pattern: Pattern 4 0.3 0.7 3.2 0.3 0.2 -0.1 -0.5 -0.5 -0.3 0.6 -1.8 -0.1 -1.7 -0.4
Birth weight of first child 1.7 3.1 9.1 -0.8 -0.3 0.4 1.4 0.9 1.6 -2.6 2.0 0.4 -2.7 -3.0
Peak expiratory flow (PEF) 1.1 2.7 8.0 -1.7 0.6 0.4 2.4 0.2 0.9 -2.2 2.1 0.8 -1.3 -2.8
Pulse wave reflection index 0.4 0.5 1.8 0.1 -0.2 -1.0 0.4 1.0 0.5 0.3 0.5 0.0 -1.3 -1.0
Ever highly irritable/argumentative for 2 days 1.2 1.5 6.4 0.5 -1.0 0.6 1.1 1.5 1.4 -1.2 2.5 -0.1 -0.6 -0.9
Loud music exposure frequency 0.3 0.3 2.2 0.2 0.1 -0.1 -1.5 0.1 -0.2 0.7 0.7 0.1 -0.1 -0.3
Qualifications: O levels/GCSEs or equivalent 2.5 4.0 9.9 -3.0 1.9 2.5 2.1 -1.0 -0.2 -3.1 0.1 1.9 -1.1 -2.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.0 0.8 -1.0 -0.8 -0.4 1.0 1.0 0.3 -0.2 -0.8 -0.2 -0.2
Blood clot in the leg (DVT) 2.1 2.6 5.4 1.6 -2.1 -1.5 -0.2 1.9 2.3 -0.4 1.9 -1.8 -1.2 -1.4
Medication: Paracetamol 0.5 0.9 5.2 0.6 -0.7 -2.3 -0.5 0.7 0.5 0.2 -0.8 -1.0 -0.9 -0.7
Headache pain in last month 0.4 0.6 3.9 0.4 -0.0 -2.0 -0.5 -0.5 -0.1 0.3 -1.3 -0.8 -0.1 -0.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 8.1 -0.5 0.7 0.1 -1.3 -0.8 -1.2 1.1 -2.9 0.2 -0.1 0.6
Glaucoma (self-reported) 0.7 0.8 2.2 -1.0 1.1 1.5 0.3 -1.2 -0.9 -1.3 -0.2 0.7 0.4 -0.0
Gout (self-reported) 1.6 2.2 4.6 -2.1 1.7 1.8 1.7 -1.2 -0.7 -2.0 0.4 1.9 -1.1 -0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.4 1.2 -1.1 -0.4 -1.4 0.9 0.5 0.2 0.5 -0.6 1.6 0.7
Medication: Amlodipine 0.1 0.1 0.3 0.3 0.1 -0.5 -0.1 -0.4 -0.6 0.6 -0.3 -0.0 0.1 0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 0.4 -0.2 0.3 -0.5 0.3 0.2 -0.0 -0.2 -0.3 -0.5 -0.5
Birth weight 0.3 0.7 3.6 -0.3 -0.3 0.4 -0.1 1.0 0.5 -0.8 -0.9 0.0 -1.9 -1.1
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.5 0.7 -0.2 -0.4 -0.0 0.4 -0.1 0.7 0.4 -0.3 1.2 0.5
High blood pressure (siblings) 0.4 0.6 2.0 -0.4 0.7 0.0 0.0 -0.6 -0.7 -0.5 0.9 1.1 1.4 0.5
Forced vital capacity (FVC), Best measure 0.7 2.6 9.7 -1.9 1.1 3.1 0.4 -0.8 -0.5 -3.0 0.4 2.0 0.6 -0.3
Body fat percentage 0.7 2.8 11.2 1.3 -1.6 -1.4 0.6 2.2 2.2 -0.8 3.3 -0.9 -0.8 -1.1
Leg fat percentage (right) 0.9 3.5 10.7 1.8 -2.0 -2.6 -0.1 2.3 2.3 -0.1 3.3 -1.5 -0.3 -0.8
Arm fat-free mass (right) 1.3 6.6 32.5 -1.5 0.0 1.5 2.2 0.9 1.6 -5.7 3.8 1.1 0.8 -3.4
Exposure to tobacco smoke outside home 0.5 0.7 4.5 0.6 -0.5 -2.1 0.3 -0.0 0.5 -0.0 0.7 -0.9 0.8 -0.1
Comparative body size at age 10 1.5 4.1 8.1 2.3 -2.3 -2.8 -1.4 2.6 1.8 2.2 0.3 -2.2 -2.0 -0.5
Number of full brothers 1.4 1.8 4.8 1.3 -1.4 -2.2 0.0 1.4 1.1 1.4 1.5 -1.6 1.0 -0.5
Worry too long after embarrassment 1.3 2.1 7.6 1.3 -1.3 -2.7 -2.2 1.0 1.1 0.9 -0.4 -1.8 0.6 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.1 1.0 -1.1 -1.4 0.2 1.1 1.3 -0.2 1.1 -1.0 0.3 -0.5
Wheeze or whistling in the chest in last year 2.3 4.1 12.5 1.0 -1.8 -0.8 -0.0 2.1 2.9 -1.5 3.5 -1.5 -1.9 -2.6
Number of children fathered 0.5 0.5 1.7 -0.6 0.7 1.3 0.3 -0.4 -0.3 -0.9 0.5 0.8 -1.0 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.9 0.7 -0.7 -1.7 -0.9 1.2 0.9 -0.6 0.1 -0.7 -1.0 -1.1
Age at first live birth 0.8 1.4 3.6 -1.5 1.2 1.9 1.6 -0.9 -0.7 -0.7 -0.8 1.4 -1.3 -0.1
Pulse wave peak to peak time 0.3 0.3 1.6 0.6 -0.6 0.4 -0.5 0.5 0.6 -0.3 1.2 -0.4 0.5 -0.3
Health satisfaction 0.5 0.7 2.3 -0.4 0.5 0.6 0.6 -0.2 0.2 -1.2 0.7 0.8 -1.1 -1.5
Shortness of breath walking on level ground 0.3 0.3 2.2 0.2 -0.2 0.1 -0.7 0.2 0.2 0.1 0.9 0.1 1.5 0.2
Qualifications: College or University degree 1.2 3.7 11.4 -0.5 1.2 3.4 -0.5 -1.3 -2.3 1.3 -3.3 1.1 0.7 2.5
Eye problems/disorders: None of the above 1.8 2.1 6.6 1.0 -1.5 -2.6 0.6 1.8 1.6 1.5 0.0 -1.5 -0.9 -1.5
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.9 -1.6 1.4 1.3 0.9 -1.7 -0.7 -1.5 0.4 1.4 0.6 -0.6
Emphysema/chronic bronchitis 1.5 1.7 4.0 -1.4 1.8 1.4 0.4 -1.2 -1.8 -0.2 -0.9 2.0 0.4 1.3
Medication for pain relief, constipation, heartburn 1.0 1.8 4.2 -1.2 1.1 2.1 1.8 -1.0 -0.9 0.6 0.3 1.6 1.9 1.0
Neck or shoulder pain in last month 1.2 1.7 4.4 2.1 -1.7 -1.0 -0.6 1.7 1.6 0.4 0.7 -1.0 -1.6 -0.3
Medication: Blood pressure 0.7 1.3 6.1 -0.3 0.0 0.6 1.8 0.2 0.7 -1.8 2.5 0.6 0.1 -0.2
Angina (self-reported) 0.2 0.3 2.0 0.3 -0.3 -0.1 -0.3 -0.2 0.1 0.0 0.7 -0.2 1.4 0.7
Migraine (self-reported) 0.7 0.9 2.1 -1.5 1.4 -0.7 0.6 -1.2 -0.7 -0.7 -0.6 1.3 -0.4 0.3
Medication: Ibuprofen 0.8 0.9 2.1 1.2 -0.8 -1.3 -1.4 0.6 0.1 1.0 -1.2 -1.2 -0.6 -0.0
Medication: Allopurinol 2.2 2.9 6.3 -2.4 2.5 1.4 0.4 -1.8 -1.9 -1.8 -0.9 2.5 -1.0 -0.2
Medication: Omeprazole 0.2 0.3 0.9 0.3 -0.4 -0.9 0.0 0.4 0.3 0.4 0.9 -0.5 0.6 0.1
Medication: Seretide 50 evohaler 0.8 1.0 2.0 1.2 -1.3 -0.2 -0.8 1.4 1.0 1.1 0.7 -1.3 -0.4 0.3
Mean time to correctly identify matches 0.5 0.9 3.3 0.6 -0.2 -1.8 -1.6 -0.4 -0.7 0.5 -0.8 -0.8 0.8 1.2
Heart disease (mother) 0.5 0.6 2.3 -0.2 0.4 -0.3 0.4 -0.6 -0.9 0.4 -0.9 0.2 1.5 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.9 1.1 -1.1 -1.7 -0.7 1.1 0.9 0.4 0.7 -1.2 -0.6 -0.5
Whole body fat mass 0.9 3.7 17.2 0.4 -1.2 -0.5 1.5 1.9 2.2 -2.6 4.2 -0.2 -0.1 -1.9
Leg fat mass (right) 1.1 4.2 18.2 1.0 -1.8 -1.4 0.9 2.4 2.6 -2.1 4.3 -0.9 -0.1 -1.9
Arm predicted mass (right) 1.3 6.8 33.1 -1.7 0.2 1.6 2.2 0.8 1.4 -5.8 3.9 1.4 0.9 -3.3
Pulse rate, automated reading 0.1 0.3 0.9 -0.5 0.4 0.9 0.3 -0.1 -0.3 -0.0 -0.9 0.4 0.6 1.0
Alcohol intake frequency. 0.7 1.7 11.4 0.8 -0.5 -0.9 -0.6 -0.1 0.3 -0.5 1.5 -0.5 3.4 1.5
Comparative height size at age 10 4.1 23.1 94.9 -4.6 1.8 4.7 4.4 0.7 1.9 -9.7 5.6 3.6 -2.4 -6.3
Number of full sisters 0.5 0.6 1.8 0.9 -0.6 -1.0 -0.7 -0.1 -0.1 1.3 -1.1 -0.9 -0.1 0.7
Suffer from ‘nerves’ 2.0 3.2 8.5 2.2 -2.1 -2.9 -2.0 1.8 1.8 0.4 -0.9 -2.2 -0.9 -0.3
Overall health rating 0.8 1.7 4.8 0.8 -1.0 -2.2 -1.5 1.0 1.5 -1.4 1.5 -1.0 0.0 -1.3
Chest pain or discomfort 0.1 0.2 0.8 0.0 -0.2 -0.4 0.2 -0.0 0.3 -0.2 0.9 -0.3 0.7 -0.3
Had major operations 0.2 0.2 1.1 0.2 -0.2 0.3 0.4 0.4 0.7 -0.0 0.2 0.4 -1.1 -0.1
Age at last live birth 0.3 0.4 1.2 0.1 -0.2 1.1 1.0 0.2 0.4 0.7 -0.2 -0.1 -1.1 0.1
Family relationship satisfaction 1.6 2.0 6.3 1.5 -1.3 -2.5 -0.7 1.6 1.3 1.1 1.4 -1.1 -0.9 -1.2
Leg pain on walking 0.3 0.4 0.8 0.7 -0.7 -0.2 0.5 0.9 0.6 -0.4 0.9 -0.0 -0.9 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.6 1.0 -1.3 -1.9 1.9 0.9 1.4 0.8 0.9 -1.1 1.1 -0.1
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.9 -1.4 1.0 1.0 0.8 -0.6 -0.4 -1.0 -0.1 1.2 -0.4 -0.2
Illness, injury, bereavement, stress in last 2 years 2.5 3.1 5.9 -1.7 2.1 1.0 0.6 -2.2 -2.4 0.8 -1.6 1.7 2.4 1.6
Medication: Aspirin 0.2 0.3 1.2 0.4 -0.2 0.1 -0.5 0.1 -0.2 -1.0 -0.0 -0.3 1.1 0.5
Supplements: Vitamin C 0.8 1.0 3.6 -0.8 0.5 1.7 0.5 -0.3 0.3 -1.9 1.1 0.5 -0.6 -1.0
Knee pain experienced in last month 0.3 0.5 1.5 0.5 -0.6 -0.5 -0.6 0.8 0.8 -0.9 1.2 -0.3 -0.7 -0.1
Hypertension (Self-reported) 0.3 0.9 2.5 -0.2 0.4 1.6 0.2 -0.4 -0.2 -1.2 1.1 1.0 1.5 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.7 1.0 -0.7 -0.8 -1.1 0.9 0.4 0.4 -0.2 -0.8 -1.6 -0.2
Illnesses of father: Heart disease 0.7 1.0 2.5 -0.6 1.0 0.2 0.2 -1.5 -1.5 -0.1 -0.1 1.0 1.6 1.3
Illnesses of siblings: Diabetes 0.2 0.2 0.8 -0.1 0.1 0.4 0.9 -0.1 -0.3 0.6 0.7 -0.1 0.4 0.1
Smoking status: Previous 0.8 1.2 3.0 1.3 -1.4 -1.7 -0.9 1.0 1.1 1.0 0.8 -1.5 0.4 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 15.8 -2.1 1.1 2.7 1.9 -0.8 0.2 -4.0 1.1 1.8 0.5 -1.3
Whole body fat-free mass 1.4 8.1 40.9 -2.6 1.0 2.3 2.7 0.0 0.8 -6.4 3.4 2.2 1.3 -3.1
Leg fat-free mass (right) 1.3 7.0 30.4 -2.6 1.3 2.4 3.0 -0.4 0.4 -5.5 3.2 2.3 1.5 -2.4
Arm fat percentage (left) 0.5 1.9 10.1 0.8 -1.1 -1.6 1.1 1.4 1.6 -0.3 3.2 -0.5 0.1 -0.4
Average weekly red wine intake 0.2 0.4 2.4 0.4 -0.1 0.1 0.3 0.4 0.0 0.5 -0.4 0.1 -1.5 -0.8
Handedness (chirality/laterality): Left-handed 1.9 2.4 6.4 2.0 -1.4 -2.2 -2.5 0.9 0.2 1.9 -0.6 -1.7 -0.4 1.1
Mood swings 3.9 7.2 25.6 2.4 -3.0 -5.1 -2.8 2.8 3.2 -0.3 1.1 -3.1 -0.5 -1.5
Loneliness, isolation 1.3 1.8 6.9 0.9 -1.2 -2.6 -2.0 1.1 1.3 -1.0 0.8 -1.1 -0.0 0.1
Long-standing illness, disability or infirmity 0.5 0.7 2.8 0.9 -0.2 0.7 -1.2 -0.1 -0.5 -0.4 0.8 0.1 1.3 1.7
Ever had bowel cancer screening 0.2 0.2 1.0 -0.3 0.1 0.0 1.0 0.1 0.2 -0.7 -0.1 0.5 -0.7 -0.5
Diabetes diagnosed by doctor 1.5 2.4 9.7 0.0 0.8 -0.6 -1.5 -1.2 -2.0 0.6 -0.6 0.6 3.1 2.7
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.5 0.7 -0.3 -0.3 -0.3 0.0 -0.1 0.5 -0.1 -0.4 -0.6 0.2
Friendships satisfaction 0.3 0.4 0.8 -0.2 0.2 -0.8 -0.7 0.2 0.5 -0.7 0.8 0.4 -0.7 -0.9
Qualifications: nursing, teaching 1.2 1.9 5.6 -1.6 1.2 2.4 0.7 -1.0 -0.9 -1.4 -1.3 1.0 -1.9 -0.8
Commuting to job workplace: Walk 0.4 0.5 2.7 0.6 -0.2 0.9 0.9 0.5 -0.2 1.7 0.6 0.2 0.1 0.4
Eye problems/disorders: Cataract 0.6 0.7 2.2 -0.8 0.9 1.5 -0.5 -1.1 -0.8 -0.9 -0.4 0.8 -0.2 0.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.7 -0.4 0.1 -0.8 -0.5 0.0 0.2 -0.5 -0.2 -0.1 -0.2 -0.8
Medication for cholesterol 0.9 1.3 6.0 -0.0 -0.3 -0.1 1.7 0.4 0.7 0.6 0.2 -0.5 -2.4 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 3.5 0.7 -0.9 -1.0 0.5 1.2 1.5 -0.3 1.9 -0.1 -0.6 -0.5
Back pain experienced in last month 1.2 1.7 6.6 -0.1 -0.4 0.0 0.8 1.2 1.2 -2.3 2.6 -0.1 -0.6 -1.7
Mineral and other dietary supplements 0.3 0.4 1.4 0.5 -0.5 -0.0 -0.5 1.1 0.5 1.2 0.1 -0.1 -0.3 -0.5
Breast cancer (self-reported) 0.8 1.0 4.5 -1.4 1.1 0.7 2.1 -0.5 -0.6 -0.3 0.1 1.2 -0.2 -0.2
Asthma (self-reported) 0.6 1.3 2.9 -1.1 0.7 0.9 1.7 -0.3 0.2 -1.6 1.7 0.8 -0.7 -1.4
Osteoporosis (self-reported) 0.6 0.7 1.9 -0.7 1.0 -0.4 -0.6 -1.1 -1.4 0.5 -1.3 0.2 0.6 0.8
Osteoarthritis (self-reported) 1.0 1.2 3.5 -0.5 0.1 1.6 0.8 0.5 0.7 -1.5 1.9 0.7 -1.3 -1.3
Medication: Aspirin 0.2 0.2 1.0 -0.1 0.2 0.1 -0.1 -0.4 -0.4 -1.0 -0.2 -0.1 1.0 0.4
Medication: Gliclazide 0.8 1.0 3.2 0.6 -0.9 -1.8 -1.2 0.6 0.8 -0.7 1.0 -1.3 0.7 -0.4
Illnesses of father: None of the above (group 1) 1.0 1.3 2.2 0.8 -1.1 -1.2 0.4 1.3 1.5 0.5 1.5 -1.2 -0.8 -1.4
Smoking status: Current 0.7 1.0 3.1 -0.5 -0.2 -0.8 0.6 0.2 0.9 -1.5 1.3 -0.1 -1.8 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.9 -0.3 0.9 1.3 -2.0 -1.3 -1.5 1.2 -1.2 0.8 1.1 1.9
Whole body water mass 1.4 8.2 41.8 -2.6 1.1 2.3 2.7 -0.0 0.8 -6.5 3.4 2.2 1.2 -3.1
Leg predicted mass (right) 1.3 7.1 30.0 -2.6 1.3 2.4 3.1 -0.4 0.4 -5.5 3.2 2.2 1.5 -2.4
Arm fat mass (left) 0.6 2.6 13.9 0.3 -0.9 -0.9 1.3 1.4 1.7 -2.2 3.7 -0.2 0.4 -1.3
Number of self-reported non-cancer illnesses 1.2 2.1 11.5 -0.7 0.5 1.1 -0.0 -0.1 0.4 -3.4 2.8 1.1 -0.6 -0.8
Average weekly champagne plus white wine intake 0.5 0.7 1.4 1.2 -0.7 0.2 -1.0 0.8 0.1 0.9 -1.2 -0.6 0.3 0.9
Miserableness 3.8 6.7 23.6 2.4 -2.9 -4.9 -2.0 2.6 2.9 0.7 1.4 -3.3 -0.3 -1.6
Guilty feelings 4.5 6.9 20.1 2.9 -3.0 -4.5 -3.5 2.4 2.5 0.8 0.4 -3.6 -0.1 -0.8
Wears glasses or contact lenses 0.5 0.6 4.5 0.7 -0.1 -0.2 -0.4 0.2 -0.4 0.6 -0.2 0.1 2.1 1.0
Ever taken oral contraceptive pill 1.0 1.1 3.1 1.8 -1.2 0.4 -1.6 0.6 0.4 1.3 -0.4 -1.2 0.4 0.9
Hearing aid user 1.2 1.4 4.0 0.8 -0.0 0.0 -1.1 -0.5 -1.3 2.0 -1.9 -0.6 1.1 1.6
Mother’s age at death 0.6 0.8 4.0 1.0 -0.3 0.3 -0.9 0.4 -0.4 2.0 -1.2 -0.1 0.7 0.7
Financial situation satisfaction 0.8 1.0 3.5 1.3 -0.8 -1.0 -1.2 0.7 0.3 1.9 -0.3 -1.1 -0.5 -0.6
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.1 -0.2 -0.1 0.2 0.2 -0.1 0.3 -1.1 0.5 -0.2 0.2 -0.4
Commuting to job workplace: Public transport 0.9 1.0 4.5 0.8 -0.2 0.5 -1.1 -0.0 -0.5 0.8 -2.1 -0.2 1.0 1.6
Eye problems/disorders: Glaucoma 0.2 0.3 1.5 -0.4 0.3 0.5 0.5 -0.3 0.1 -1.2 0.5 0.0 -0.3 -0.6
Medication: Blood pressure 1.0 2.0 4.9 -0.8 1.0 1.1 -1.4 -1.1 -1.2 -1.6 -0.8 1.3 2.2 2.2
Pain type(s) experienced in last month: Hip pain 0.9 1.1 5.7 0.5 0.2 1.3 -0.6 -0.6 -0.9 0.7 -1.0 0.3 1.1 2.4
Supplements: Fish oil (including cod liver oil) 0.8 1.1 3.0 -1.2 1.2 0.7 0.4 -1.7 -1.2 -1.7 -0.1 0.8 0.5 0.6
High cholesterol (Self-reported) 0.1 0.1 0.3 -0.2 0.3 -0.6 -0.1 -0.3 -0.5 -0.2 0.4 0.3 0.2 0.3
Medication: Bendroflumethiazide 0.8 1.2 6.2 1.3 -0.9 -0.3 -2.5 0.7 0.3 -0.4 -0.7 -0.8 -0.3 1.4
Medication: Paracetamol 0.8 1.3 6.0 0.9 -1.0 -2.4 -0.9 1.1 0.7 0.5 -0.4 -1.3 -0.7 -1.0
Medication: Lisinopril 0.5 0.7 3.3 0.4 -0.2 1.8 0.0 0.6 0.3 -0.6 1.5 0.7 0.2 0.5
Medication: Atorvastatin 0.2 0.2 1.3 -0.1 0.0 0.4 0.0 0.4 0.2 -0.1 1.2 0.1 -0.1 -0.7
Illnesses of father: High blood pressure 0.9 1.1 3.1 -0.8 0.9 1.1 -0.4 -1.2 -1.1 -1.0 -1.1 0.5 1.8 1.2
Alcohol drinker status: Never 0.3 0.4 1.9 0.2 0.3 0.7 -0.3 -0.0 -0.4 -0.3 0.3 0.7 1.4 0.8
Ever smoked 0.6 1.1 4.2 0.1 -0.7 -1.1 -0.4 0.3 1.1 -0.3 0.4 -1.0 -2.1 -1.9
Basal metabolic rate 1.4 8.2 40.8 -2.5 0.9 2.0 2.8 0.3 1.1 -6.4 3.8 2.0 1.0 -3.2
Leg fat percentage (left) 1.0 3.8 11.7 1.9 -2.1 -2.7 0.0 2.3 2.4 0.2 3.4 -1.7 -0.3 -0.9
Arm fat-free mass (left) 1.2 6.4 32.8 -1.5 0.1 1.3 1.9 0.9 1.6 -5.7 3.8 1.2 0.8 -3.2
Number of operations (self-reported) 0.3 0.4 1.7 -0.3 0.0 0.2 0.9 0.2 0.5 -1.3 0.4 0.6 -0.9 -0.6
Average weekly beer plus cider intake 0.5 0.8 3.4 0.3 -0.7 -1.9 0.2 0.4 0.7 0.2 1.3 -1.0 0.2 -1.1
Irritability 1.7 2.9 9.2 1.4 -1.6 -3.0 -2.7 1.5 1.4 0.8 -0.5 -2.0 -0.5 -1.2
Risk taking 1.3 1.9 9.0 1.7 -1.0 -0.6 -1.1 1.0 0.2 3.0 0.4 -0.5 1.5 1.7
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.8 0.6 -1.0 -1.0 1.7 1.1 1.0 0.6 0.5 -0.8 -0.3 -0.6
Fractured/broken bones in last 5 years 0.5 0.6 2.2 0.5 -0.5 0.8 0.6 1.2 0.5 0.9 -0.6 -0.2 -1.5 -0.4
Age started oral contraceptive pill 1.8 2.3 6.4 1.7 -1.5 -0.1 -2.4 1.6 1.1 0.9 -0.7 -1.5 -2.5 -0.6
Diastolic blood pressure, automated reading 0.5 1.7 5.8 -1.1 0.5 1.1 1.0 0.2 0.7 -2.4 1.9 0.8 -0.4 -2.1
Ever depressed for a whole week 0.1 0.2 0.9 0.2 -0.4 -0.9 0.0 0.4 0.4 -0.2 0.1 -0.4 -0.3 0.2
Unable to work because of sickness or disability 0.2 0.3 1.6 -0.2 0.0 -0.3 0.1 -0.3 0.5 -1.2 0.8 0.2 -0.4 -0.8
Commuting to job workplace: Cycle 0.4 0.5 1.5 0.6 -0.2 0.6 -0.6 -0.1 -0.5 1.2 -0.5 -0.4 1.1 0.7
Myopia 0.8 1.2 4.4 -1.3 1.1 -1.0 0.5 -1.2 -0.7 -2.1 -0.0 0.7 1.6 -0.3
Vascular/heart problems diagnosed by doctor 0.4 1.2 4.6 0.2 -0.1 -1.2 0.2 -0.0 -0.4 2.1 -2.0 -0.8 -1.2 -0.3
Cholesterol lowering medication 1.0 1.5 3.8 -1.1 1.3 1.1 -0.4 -1.3 -1.6 -0.2 -0.6 1.3 1.5 2.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.7 0.6 -0.8 -0.9 0.3 0.9 1.0 -0.1 1.3 -0.8 -0.1 -0.4
Pain experienced in last month 0.7 1.1 4.2 1.0 -1.0 -0.2 -0.5 0.5 0.3 2.1 -1.0 -1.2 0.8 1.5
Supplements: Calcium 0.9 1.0 2.7 -1.6 1.2 -0.1 0.7 -0.7 -0.5 -1.4 -0.5 0.9 -0.8 -1.3
Basal cell carcinoma (self-reported) 0.6 0.7 2.6 -0.8 0.2 0.0 -0.0 0.2 0.4 -1.6 0.5 0.1 -1.6 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 4.6 -1.2 0.7 0.2 0.1 -0.1 0.1 -2.1 2.1 1.0 0.9 -0.4
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 5.4 1.6 -2.1 -1.4 -0.5 2.1 2.3 -0.6 1.8 -2.0 -1.3 -1.7
Heart disease (siblings) 0.2 0.2 1.0 -0.6 0.4 0.0 -0.2 -0.2 -0.2 -1.0 0.8 0.6 -0.2 -0.2
Alcohol drinker status: Previous 0.7 0.8 5.0 -0.5 0.7 -0.3 -0.3 -1.2 -0.9 -0.4 -0.3 0.1 2.2 0.4
Pack years of smoking 0.5 0.8 3.8 0.5 -0.7 -0.0 -0.1 0.9 1.0 -0.5 1.1 -0.4 -1.9 -0.7
Impedance of whole body 0.3 1.4 5.2 0.3 -0.2 1.8 -1.1 0.2 -0.2 0.7 -2.2 -0.1 -2.3 0.6
Leg fat mass (left) 1.1 4.3 18.9 1.0 -1.8 -1.5 1.1 2.3 2.7 -1.9 4.3 -1.0 -0.2 -2.0
Arm predicted mass (left) 1.2 6.5 33.9 -1.7 0.3 1.3 1.9 0.7 1.4 -5.8 3.7 1.3 0.8 -3.2