Hub : Genes

MPP6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.17 0.037 1.9e-08 0.076 0.072 0.071 0.091 0.079 1.4e-09 4.0e-09 5.6e-09 3.3e-11 6.9e-10
2 GTEx Adipose Subcutaneous 0.10 0.039 3.8e-03 0.026 NA 0.035 NA 0.033 2.9e-03 NA 7.3e-04 NA 9.5e-04
3 GTEx Artery Aorta 0.13 0.052 5.5e-03 0.088 NA 0.052 NA 0.067 1.4e-05 NA 8.0e-04 NA 1.4e-04
4 GTEx Artery Tibial 0.14 0.039 1.8e-05 0.035 NA 0.030 NA 0.037 8.8e-04 NA 1.9e-03 NA 6.3e-04
5 GTEx Cells Transformed fibroblasts 0.15 0.044 1.0e-05 0.062 NA 0.067 NA 0.086 2.1e-05 NA 9.1e-06 NA 5.0e-07
6 GTEx Esophagus Gastroesophageal Junction 0.50 0.108 3.4e-05 0.105 NA 0.143 NA 0.172 1.2e-04 NA 7.8e-06 NA 8.4e-07
7 GTEx Esophagus Muscularis 0.34 0.065 2.5e-09 0.221 NA 0.188 NA 0.195 1.5e-13 NA 1.4e-11 NA 5.5e-12
8 GTEx Lung 0.15 0.042 3.4e-06 0.068 NA 0.104 NA 0.098 6.2e-06 NA 2.5e-08 NA 6.4e-08
9 GTEx Muscle Skeletal 0.10 0.041 8.1e-04 0.081 NA 0.058 NA 0.070 2.4e-08 NA 2.1e-06 NA 2.2e-07
10 GTEx Nerve Tibial 0.30 0.061 5.1e-08 0.042 NA 0.098 NA 0.071 5.8e-04 NA 1.9e-07 NA 9.2e-06
11 GTEx Testis 0.53 0.066 2.5e-11 0.495 NA 0.427 NA 0.446 7.3e-25 NA 1.5e-20 NA 1.0e-21
12 METSIM Adipose 0.15 0.032 9.2e-15 0.136 0.106 0.129 0.133 0.135 8.4e-20 1.4e-15 9.9e-19 2.4e-19 1.1e-19
13 ROSMAP Brain Pre-frontal Cortex 0.07 0.024 2.4e-04 0.051 0.029 0.023 0.035 0.034 4.0e-07 9.4e-05 5.3e-04 2.2e-05 2.6e-05
14 YFS Blood 0.04 0.014 2.3e-07 0.013 0.024 0.020 0.029 0.030 3.3e-05 2.3e-08 2.6e-07 7.7e-10 4.4e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Alzheimer’s Disease (in mother) 0.4 0.4 1.2 0.2 0.3 -1.0 -1.1 0.5 -0.8 -0.6 -0.6 -0.6 -0.6 -0.2 -0.7 -0.4 0.4
Alzheimer’s Disease (in father) 0.6 0.7 2.2 -0.0 -0.4 1.1 1.0 0.5 -0.0 -1.0 -1.2 -0.7 1.1 -0.3 -0.7 -0.4 -1.5
Alzheimer’s Disease (including proxy) 0.2 0.2 1.2 0.1 0.7 -0.5 -0.6 -0.1 0.3 -0.2 -0.3 -1.1 -0.3 -0.4 -0.3 -0.8 -0.0
Crohns Disease (2017) 0.4 0.8 2.4 -0.9 1.5 -0.4 -0.2 -0.3 1.1 1.3 1.1 -0.4 0.8 -0.6 1.6 -0.5 0.0
Irritable Bowel Disease (IBD) 0.1 0.3 1.2 -0.4 0.6 0.3 0.2 -0.5 0.7 0.8 0.4 0.3 0.4 0.2 1.1 0.7 -0.1
Ulcerative Colitis (UC) 0.1 0.3 0.9 -0.2 0.0 0.9 0.7 -0.4 0.3 0.3 -0.2 0.9 0.2 0.4 0.5 0.9 -0.3
Major Depression (MDD) 2.1 2.6 5.5 -0.6 2.3 -2.3 -2.2 -0.9 0.8 1.5 2.1 -1.4 -2.1 -1.2 0.7 -1.6 1.2
Reaction Time 0.8 1.5 6.4 -1.1 1.1 -2.5 -2.3 0.3 -1.0 -1.1 0.1 -0.0 -0.9 -1.0 -1.2 -0.9 0.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.2 0.8 0.4 -1.5 -1.5 -0.2 -0.1 -0.3 0.4 1.3 -1.8 0.4 -0.6 0.4 1.1
Breast Cancer 1.0 2.5 6.6 -0.7 -1.2 -0.3 0.1 2.3 -2.2 -2.3 -1.7 -0.7 -0.8 -1.1 -2.2 -1.0 -2.6
Ovarian Cancer 1.8 2.3 5.2 0.1 0.1 1.5 1.3 -1.6 2.2 2.2 1.6 -2.2 0.4 1.2 2.3 0.9 1.4
Prostate Cancer 0.8 1.2 3.9 -1.2 -0.0 1.1 1.2 2.0 -1.0 -0.5 -0.3 0.8 1.9 -1.2 -0.2 -0.6 -1.1
Age at First Birth 0.7 1.0 2.4 1.0 -0.9 -0.1 0.0 1.3 -1.4 -1.6 -1.1 0.7 0.4 0.3 -1.5 1.0 0.7
Bipolar Disorder 2.7 2.7 6.8 0.1 2.0 -2.4 -2.6 -1.7 0.9 1.5 2.0 -2.0 -0.7 0.6 1.0 0.7 2.2
Body Mass Index (BMI) (2010) 1.2 1.7 6.2 2.0 -1.9 0.6 0.3 -0.7 -0.8 -0.9 -0.8 0.9 0.6 2.1 -0.5 2.5 0.7
Coronary Artery Disease (CAD) 1.3 1.6 4.3 1.4 -2.1 1.6 1.2 0.2 -0.9 -1.4 -1.4 -1.2 0.9 1.5 -0.9 1.2 -0.6
Crohns Disease (2012) 1.0 1.6 4.4 1.7 -2.1 1.1 0.8 -0.1 -1.4 -1.2 -1.2 0.5 -1.4 1.6 -1.2 1.5 0.3
Mean Putamen Volume 0.2 0.3 1.1 0.2 -0.3 0.5 0.3 -0.4 0.1 0.3 0.3 -0.1 0.5 0.8 -0.3 1.1 0.7
Fasting Glucose 0.5 0.6 2.4 -0.3 0.3 0.1 0.2 0.5 -0.8 -0.7 -0.9 1.1 0.9 -0.8 -0.4 -0.4 -1.6
HbA1C 0.6 0.7 1.7 -1.3 1.3 -0.3 -0.2 0.5 0.1 1.1 0.8 0.4 1.0 -0.9 0.9 -0.9 -0.0
HDL Cholesterol 0.6 0.9 2.7 -1.3 1.0 0.6 0.7 -0.1 1.1 0.9 0.9 -1.6 0.5 -0.8 0.9 -1.0 -1.1
LDL Cholesterol 2.1 3.2 7.3 -0.6 -2.4 2.7 2.7 1.9 -1.1 -1.3 -2.3 2.6 1.6 -0.5 -1.0 -0.4 -1.5
Lupus 0.8 1.2 4.3 0.3 0.7 -0.4 -0.7 -2.1 1.2 1.5 1.8 -0.4 -0.1 0.7 1.4 0.5 1.2
Neuroticism 3.0 4.5 12.1 -0.2 1.7 -0.9 -0.8 -2.8 3.0 3.2 3.5 -2.1 -0.9 0.5 3.1 -0.3 1.7
Primary Biliary Cirrhosis 0.5 0.7 3.9 0.9 -0.4 -0.3 -0.5 0.1 -0.7 -1.0 -0.5 2.0 0.4 0.7 -0.7 1.1 1.0
Rheumatoid Arthritis 0.6 0.8 2.0 0.2 1.0 -1.0 -1.2 -1.4 1.0 0.9 1.0 0.6 -0.1 0.5 0.8 0.4 1.2
Schizophrenia 2.0 4.4 8.9 0.8 2.4 -2.8 -3.0 -2.3 1.6 2.2 2.7 -1.9 -2.0 0.9 1.4 0.9 2.8
Triglycerides 2.3 3.7 9.0 -0.2 -2.1 1.2 1.3 3.0 -2.4 -2.6 -2.9 1.4 1.0 -0.9 -2.0 -0.8 -2.4
Type 2 Diabetes (T2D) 0.1 0.1 0.3 -0.0 -0.2 0.3 0.3 0.2 0.1 -0.0 -0.6 -0.2 0.4 -0.2 0.3 0.1 0.2
Ulcerative Colitis 0.2 0.3 1.1 -0.1 0.3 -0.9 -0.6 0.2 0.3 0.2 0.4 -0.6 -0.6 -0.4 0.1 -1.1 0.4
Blood Eosinophil Count 0.1 1.2 5.0 0.0 1.1 -0.7 -0.7 -0.8 1.4 1.4 0.9 -1.1 -0.3 0.4 1.6 0.2 2.2
Blood Platelet Count 0.9 11.0 25.1 -0.7 -3.8 4.5 5.0 4.3 -2.1 -3.1 -4.4 2.7 1.9 -1.8 -2.1 -1.7 -4.5
Blood Red Count 0.4 4.4 9.9 -0.3 -1.9 1.4 1.6 2.8 -2.2 -3.1 -3.1 0.6 1.2 -1.2 -2.8 -0.9 -3.0
Blood White Count 0.8 5.6 17.0 -0.1 -3.0 3.7 4.1 2.6 -1.2 -1.7 -2.8 2.1 2.8 -0.8 -0.5 -0.4 -2.5
Heel T-Score 0.8 6.2 11.3 -3.2 1.0 2.7 3.1 0.7 2.5 2.6 1.5 0.4 1.7 -3.4 3.1 -3.3 -2.5
BMI 1.2 6.8 25.5 -0.5 -2.0 3.3 3.5 2.5 -0.9 -1.9 -2.3 5.0 3.7 -0.8 -1.2 -0.1 -3.2
Height 0.6 11.9 32.9 2.9 1.3 -5.2 -5.7 -2.9 -0.5 -0.1 2.7 -3.1 -5.6 3.2 -1.4 2.8 4.4
Waist Hip Ratio (WHR) 0.6 2.9 8.5 0.6 -2.2 0.8 1.1 2.4 -2.9 -2.5 -2.9 1.1 0.2 -0.6 -1.7 0.0 -0.9
Systolic Blood Pressure 1.6 8.3 38.7 -0.3 -3.9 6.1 6.2 1.7 0.3 -0.7 -2.2 2.0 2.5 0.4 1.2 0.6 -2.1
Smoking Status 1.6 3.8 10.4 -2.2 -0.7 0.7 1.6 3.2 -1.8 -0.7 -1.1 1.1 0.9 -3.2 -0.1 -2.9 -2.9
Allergy or Eczema 1.0 2.7 10.0 -1.3 2.1 -1.5 -1.2 0.8 0.3 1.0 1.1 -3.2 -0.4 -2.3 0.8 -2.9 -0.7
Cardiovascular Disease 0.8 2.7 9.5 -0.1 -1.7 2.9 3.1 1.0 0.1 -0.7 -0.9 2.3 2.1 -0.1 0.2 0.2 -2.1
Hypothyroidism (self reported) 1.5 3.5 10.7 0.1 2.4 -3.2 -3.3 -2.1 1.3 1.7 1.9 -1.2 -2.3 0.3 0.3 0.1 1.7
Respiratory disease 1.1 2.4 4.7 -2.1 1.6 0.2 0.6 0.6 1.5 2.0 1.5 -1.8 1.3 -2.1 1.6 -2.2 -0.5
Type 2 Diabetes (T2D) 1.5 2.8 12.4 -0.9 1.1 1.7 1.6 -0.1 2.3 2.2 1.0 1.5 3.5 -0.1 2.4 0.2 0.8
Lung FEV1/FVC ratio 0.8 3.9 9.4 2.1 -2.3 0.2 -0.2 1.3 -2.5 -3.1 -3.0 0.8 0.6 1.4 -2.8 1.6 -2.3
Lung FVC 0.2 0.8 2.8 -0.6 0.7 -0.4 -0.4 -1.7 1.5 1.0 1.1 -0.9 -0.7 -0.0 0.9 -1.0 0.3
Neuroticism 3.8 9.4 25.6 -0.9 2.6 -1.1 -0.9 -3.8 4.5 4.8 4.9 -2.9 -1.7 0.2 5.1 -1.2 1.3
Chronotype (morning person) 1.0 2.4 6.1 0.1 -1.8 2.5 2.3 1.9 -0.8 -1.1 -1.7 2.4 1.4 0.0 -1.3 0.5 -1.2
Hair Pigment 0.1 1.8 8.0 -0.2 1.1 -1.8 -1.8 -0.1 0.2 1.3 1.6 -2.8 -1.1 -0.1 0.3 -0.3 1.8
Tanning 0.0 0.6 2.4 -0.7 -0.4 1.5 1.5 0.0 0.6 0.3 -0.8 1.1 0.8 -0.1 0.6 0.0 -0.5
Hand grip strength (left) 1.0 2.6 5.5 -0.5 -0.5 0.2 0.5 2.1 -2.1 -1.8 -2.3 1.1 1.4 -1.9 -1.6 -2.2 -1.9
Number of treatments/medications taken 1.3 2.4 7.8 1.5 0.8 -2.5 -2.8 -1.0 -0.6 -0.5 0.7 -0.6 -2.4 1.2 -1.0 1.2 2.2
Average weekly spirits intake 4.0 5.0 13.9 0.3 2.3 -1.4 -1.6 -3.7 3.5 2.9 3.0 -1.0 -0.4 0.8 2.5 0.5 2.8
Sensitivity / hurt feelings 1.2 2.1 7.2 -0.0 -1.0 0.8 0.6 1.3 -1.9 -2.1 -2.7 1.8 0.7 -0.2 -2.5 0.4 -0.6
Frequency of depressed mood in last 2 weeks 1.4 2.0 5.2 0.8 -1.7 0.8 0.7 1.3 -1.9 -2.3 -2.3 0.1 0.9 0.7 -2.3 1.2 -0.3
Hearing difficulty/problems: Yes 0.2 0.2 1.7 -0.3 -0.1 0.1 0.1 -0.2 0.5 -0.2 -0.4 1.3 -0.5 0.1 -0.4 0.1 0.8
Relative age of first facial hair 0.6 1.2 3.0 -1.6 0.4 0.7 0.9 1.0 -0.6 -0.6 -1.1 1.7 1.4 -1.1 -0.6 -0.7 -1.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.3 0.5 -0.3 0.6 0.3 -0.5 0.6 0.1 0.2 1.5 -0.0 0.9 0.0 1.2 0.3
Ever used hormone-replacement therapy (HRT) 0.9 1.1 4.7 1.8 -0.9 0.1 -0.3 -1.0 -0.3 0.0 0.3 -0.2 -0.6 2.2 -0.0 2.0 1.2
Ever had hysterectomy (womb removed) 1.0 1.2 3.3 -1.2 0.3 1.0 1.0 -1.0 1.2 1.3 1.8 -1.2 -0.5 -0.7 1.5 -0.8 0.6
Systolic blood pressure, automated reading 2.6 7.6 31.9 -0.0 3.5 -5.6 -5.6 -1.8 -0.2 0.7 2.1 -2.5 -3.3 -0.5 -1.0 -0.8 2.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.4 -0.9 0.4 -0.2 -0.1 0.4 0.1 0.4 0.5 -0.2 -0.8 -1.1 -0.1 -1.2 -0.5
Angina 0.8 1.1 2.9 0.1 1.7 -1.3 -1.6 -1.4 0.3 0.9 1.2 0.1 -1.2 0.1 0.7 0.2 1.1
Medication for hormone replacement therapy 1.1 1.2 6.2 0.7 0.1 -0.8 -1.2 -1.3 -0.2 0.2 0.6 0.3 -1.5 1.3 -0.3 1.6 2.5
Vitamin and mineral supplements 1.3 1.7 5.0 -2.2 0.3 0.9 1.2 1.7 0.6 0.1 -0.0 -1.2 1.8 -2.2 0.1 -1.9 -0.8
Supplements: Zinc 0.4 0.4 2.4 0.5 0.4 0.6 0.4 -0.7 0.7 0.7 0.2 1.6 -0.1 0.3 0.6 0.5 0.4
Medication: Co-codamol 1.0 1.1 5.9 1.2 -0.5 -1.2 -1.4 -0.4 -0.8 -0.6 0.0 -0.5 -2.4 0.9 -0.6 0.6 1.2
Medication: Metformin 2.1 3.0 20.2 0.1 -0.3 -1.9 -1.7 0.2 -2.1 -1.4 0.0 -1.8 -4.5 -0.7 -1.8 -1.1 -0.6
Diabetes (father) 0.5 0.6 2.6 -0.6 -0.8 1.6 1.6 0.8 -0.5 -0.0 -0.3 -0.6 0.8 -0.3 0.4 0.0 -0.3
Diabetes (mother) 2.1 2.7 11.0 0.4 -0.9 -1.6 -1.5 0.8 -3.3 -2.5 -1.6 -0.7 -1.6 -0.4 -3.0 -0.1 -0.1
Severe depression (siblings) 0.8 0.9 3.8 -1.4 -0.0 0.4 0.7 0.4 0.4 -0.1 -0.2 1.0 -0.3 -1.3 -0.4 -1.5 -2.0
Pack years adult smoking proportion 2.0 3.0 7.2 -1.3 2.7 -2.4 -2.2 -1.1 1.3 2.0 2.0 -2.1 -1.0 -1.3 1.0 -1.8 0.6
Impedance of leg (right) 0.3 1.5 5.6 0.8 0.0 -0.9 -1.1 0.1 -1.0 -1.7 -1.0 2.4 0.6 0.4 -2.2 0.5 -1.4
Leg fat-free mass (left) 0.3 1.6 9.1 -1.7 0.2 0.1 0.4 0.4 0.3 1.0 0.3 -3.0 -0.5 -1.5 1.5 -1.9 0.6
Trunk fat percentage 2.2 8.9 19.0 -0.0 3.1 -4.1 -4.4 -3.2 1.8 2.7 3.7 -4.2 -3.4 0.9 1.8 0.2 3.4
Hand grip strength (right) 0.6 1.6 4.6 -0.1 -0.3 0.7 0.8 1.4 -1.3 -1.2 -2.1 1.1 1.3 -1.4 -1.1 -1.3 -2.0
Townsend deprivation index at recruitment 0.5 0.7 2.4 -0.8 1.4 0.1 -0.1 0.1 0.7 1.0 0.4 -1.6 1.2 -0.7 0.7 -0.7 -0.6
Current tobacco smoking 0.6 1.0 4.0 0.6 0.6 0.3 -0.2 -2.0 1.6 1.1 0.7 -0.6 0.7 1.3 0.8 1.2 0.7
Average weekly fortified wine intake 1.1 1.3 2.7 -1.1 1.6 -1.2 -1.1 -1.3 1.1 1.2 1.5 -0.2 1.0 -0.6 0.9 -0.5 1.3
Maternal smoking around birth 2.1 3.0 6.4 0.8 1.0 -1.9 -2.0 -2.4 1.9 1.4 1.7 -1.6 -2.5 1.3 1.1 0.7 2.5
Fed-up feelings 2.4 4.5 15.3 1.0 -1.4 -0.1 -0.4 2.3 -3.5 -3.3 -3.4 1.9 -0.3 0.2 -3.9 0.8 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.7 12.1 1.5 -2.8 1.1 0.8 2.1 -3.2 -3.5 -3.4 0.4 0.9 1.1 -3.2 1.7 -0.6
Relative age voice broke 0.2 0.3 0.9 -0.9 0.2 0.2 0.4 0.9 -0.4 -0.5 -0.3 -0.0 0.7 -0.5 -0.3 -0.6 -0.9
Taking other prescription medications 0.6 0.9 2.6 1.4 -0.4 -0.7 -0.9 -0.7 -0.2 -0.7 0.0 -0.0 -1.5 1.4 -0.7 1.6 1.1
Age when periods started (menarche) 0.5 1.1 4.2 -1.0 1.2 -2.0 -1.8 0.3 -0.7 -0.5 0.8 -0.1 -1.3 -1.3 -1.0 -0.7 0.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.5 -1.0 0.4 0.5 0.4 -0.7 1.0 0.9 1.1 -0.8 1.2 -0.2 0.8 -0.4 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.4 1.2 -0.2 -0.6 -0.7 -0.3 -0.4 -0.5 -0.3 -0.7 -1.6 1.5 -0.5 1.4 1.0
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.8 1.4 -0.9 0.6 0.4 -0.0 -0.3 -0.6 -0.9 0.5 0.1 1.6 -0.4 1.7 1.1
Qualifications: CSEs or equivalent 0.1 0.2 1.0 -0.0 -0.5 0.6 0.6 -0.4 0.0 -0.1 -0.4 -1.0 -0.2 0.0 -0.2 0.0 0.0
Serious illness, injury or assault to yourself 0.2 0.2 1.4 -0.3 -0.1 0.4 0.2 -0.3 0.2 -0.1 -0.1 0.7 -1.2 0.2 -0.2 0.4 0.1
High blood pressure 1.1 3.2 11.8 0.2 1.6 -3.3 -3.4 -0.3 -1.2 -0.3 0.3 -2.4 -2.9 -0.2 -1.3 -0.4 1.3
Hayfever, allergic rhinitis or eczema 0.5 1.1 8.1 0.1 -0.9 1.2 1.0 -0.5 0.8 -0.3 -0.2 2.9 0.1 0.9 -0.3 1.5 0.4
Multivitamins +/- minerals 0.6 0.8 2.6 1.5 -0.1 -0.4 -0.6 -1.4 -0.6 0.3 0.2 0.7 -0.7 1.6 0.4 1.4 0.6
Stomach or abdominal pain in last month 1.9 2.4 4.3 0.4 -1.6 1.6 1.5 1.5 -1.8 -2.0 -2.1 1.9 1.7 0.7 -1.9 1.1 -0.4
Supplements: Glucosamine 0.8 1.1 4.6 1.3 0.2 -1.3 -1.5 -0.9 -0.3 0.0 0.6 -0.3 -2.1 1.2 0.1 0.7 1.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.8 -0.1 0.6 -1.0 -1.1 -0.5 -0.1 0.0 0.1 1.4 -0.6 0.3 0.3 0.3 0.9
Medication: Atenolol 1.8 2.2 5.3 -1.0 2.2 -1.2 -1.0 -1.4 1.2 1.9 2.3 -2.0 -0.8 -1.0 2.0 -0.8 0.8
Medication: Levothyroxine sodium 0.6 1.0 3.9 -0.1 -0.7 1.9 2.0 0.8 0.3 -0.4 -0.7 1.4 1.5 -0.4 0.3 -0.2 -0.3
Sitting height 0.7 4.8 8.4 -2.1 -1.1 1.9 2.3 2.8 -1.5 -1.6 -2.8 1.1 2.9 -2.7 -0.7 -2.5 -2.9
Chronic bronchitis/emphysema (father) 1.5 1.8 10.5 -0.2 1.4 -0.4 -0.5 -1.2 1.6 1.6 1.4 -3.2 -1.1 -0.1 1.3 -0.4 0.6
High blood pressure (mother) 1.6 2.3 9.4 0.4 0.8 -2.6 -2.6 -0.4 -1.0 -0.9 -0.3 -1.6 -3.1 -0.3 -1.5 -0.5 0.9
Body mass index (BMI) 2.1 9.0 25.5 0.5 2.4 -4.3 -4.4 -2.7 1.0 2.0 3.0 -5.1 -4.1 1.1 1.3 0.5 4.0
Impedance of leg (left) 0.2 1.1 7.4 0.2 0.3 -0.2 -0.3 0.2 -0.3 -0.9 -0.6 2.7 1.4 -0.1 -1.3 0.1 -1.6
Leg predicted mass (left) 0.3 1.6 9.1 -1.7 0.3 -0.0 0.3 0.4 0.2 0.9 0.3 -3.0 -0.5 -1.6 1.4 -2.0 0.6
Trunk fat mass 1.6 7.2 19.4 -0.3 2.6 -3.6 -3.7 -2.6 1.6 2.5 3.3 -4.4 -3.1 0.4 1.9 -0.3 3.0
Waist circumference 1.9 7.1 18.7 -0.7 2.9 -3.1 -3.2 -2.7 2.4 2.7 3.5 -4.3 -2.6 0.3 2.1 -0.5 2.9
Number of incorrect matches in round 0.6 1.0 3.0 1.0 -0.8 -0.6 -0.7 0.8 -1.7 -1.4 -1.3 -0.9 0.0 0.3 -1.6 0.2 -0.1
Past tobacco smoking 1.5 2.7 6.4 -2.0 -0.6 0.9 1.5 2.5 -1.6 -0.6 -1.1 1.5 1.6 -2.4 0.0 -2.3 -2.3
Alcohol usually taken with meals 2.3 3.7 16.0 -0.1 -1.5 1.7 1.9 2.1 -2.2 -2.1 -2.5 4.0 1.0 -0.6 -1.7 -0.5 -1.7
Nervous feelings 1.0 2.0 8.2 0.2 0.3 -1.4 -1.5 1.4 -2.1 -2.0 -1.6 0.9 -1.1 -0.5 -2.9 0.3 -0.2
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.1 8.3 1.4 -2.7 2.6 2.3 1.7 -2.0 -2.2 -2.9 2.1 2.0 1.3 -1.8 1.4 -1.1
Hearing difficulty/problems with background noise 0.9 1.5 6.2 -0.2 -0.3 1.8 1.6 -0.7 1.6 0.8 0.0 2.5 1.0 0.7 0.9 0.7 1.6
Hair/balding pattern: Pattern 2 0.7 0.9 3.5 0.3 -0.7 0.9 0.6 0.7 -1.2 -1.0 -1.3 1.1 0.8 0.4 -0.6 0.6 -1.9
Had menopause 2.3 2.9 9.7 0.7 1.1 -0.7 -1.1 -2.5 1.8 2.1 2.6 0.2 -1.0 1.4 1.6 1.4 3.1
Had other major operations 1.2 1.4 5.4 0.2 -0.7 0.5 0.5 1.3 -1.1 -1.9 -1.6 2.3 0.7 -0.1 -1.9 0.1 -0.6
Forced vital capacity (FVC) 1.1 4.4 11.8 -0.5 -2.0 2.2 2.3 3.4 -2.5 -2.4 -3.2 1.2 1.4 -1.0 -1.8 -0.5 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.3 0.9 -0.6 -0.2 -0.2 0.2 -0.8 -1.1 -1.0 0.1 -1.0 1.1 -1.0 1.1 0.5
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 8.5 0.6 -2.3 2.1 1.9 1.6 -1.6 -1.8 -2.9 1.5 1.0 0.6 -1.7 0.7 -0.7
Qualifications: None of the above 4.0 8.6 30.4 0.3 3.4 -5.5 -5.5 -1.5 0.3 0.8 2.8 -4.0 -4.0 -0.3 -0.2 -0.7 2.3
Financial difficulties in last 2 years 1.3 1.7 3.7 -0.5 -1.8 1.7 1.9 1.9 -0.6 -1.6 -1.8 0.5 0.7 -0.2 -1.1 0.2 -1.4
Mouth/teeth dental problems 1.8 2.8 9.2 -1.5 -0.3 2.2 2.4 1.7 -0.2 -0.2 -1.1 1.0 3.0 -1.6 0.1 -1.5 -2.6
Heart attack 0.5 0.6 1.4 0.4 -0.1 -1.0 -1.2 0.8 -1.1 -1.1 -0.5 0.5 -0.9 0.2 -1.1 0.4 -0.1
Allergy 0.7 1.7 5.7 -1.1 0.9 -0.3 0.1 1.4 -0.6 0.6 0.1 -2.4 0.8 -1.8 0.5 -2.4 -1.9
Pain all over the body in last month 0.9 1.0 3.1 1.1 -0.6 -0.7 -0.9 -1.3 -0.1 -0.8 0.1 -0.3 -1.5 1.5 -0.6 1.8 0.6
Diabetes (self-reported) 1.4 2.2 9.2 -0.4 1.1 -2.3 -2.2 -0.3 -1.2 -0.4 0.8 -2.1 -3.0 -0.9 -1.1 -1.0 -0.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.1 0.5 -1.4 0.5 0.5 -0.6 0.5 -0.2 -0.4 0.6 -0.3 1.0 -0.3 1.0 0.8
Medication: Ramipril 3.0 3.8 10.8 1.7 0.3 -2.6 -3.1 -1.6 -1.1 -0.5 0.2 0.2 -3.3 2.1 -0.6 2.1 3.2
Medication: Simvastatin 1.2 1.7 6.3 0.3 1.5 -2.3 -2.5 -1.2 -0.4 0.1 1.0 -1.2 -1.7 0.3 -0.4 0.2 1.6
Fluid intelligence score 0.5 1.1 4.2 -0.8 -1.1 2.0 2.0 0.4 0.2 0.1 -0.7 -1.2 0.4 -0.5 0.2 -0.4 -1.5
Illnesses of siblings 0.8 1.1 3.3 0.3 -1.1 1.8 1.6 0.6 -1.0 -1.0 -1.3 1.4 0.8 0.5 -0.6 1.3 0.0
Neuroticism score 3.2 6.7 21.5 0.8 -1.8 0.2 -0.0 3.0 -4.0 -4.1 -4.4 2.0 0.8 -0.3 -4.6 0.8 -1.2
Weight 0.7 3.7 16.5 -1.0 1.7 -2.3 -2.2 -1.2 1.0 1.7 1.9 -4.1 -2.0 -0.5 1.5 -1.1 2.2
Impedance of arm (right) 0.7 3.2 8.6 0.7 -1.5 1.2 1.1 1.3 -1.9 -2.4 -1.8 2.9 2.3 0.3 -2.6 0.7 -1.8
Arm fat percentage (right) 1.8 7.2 21.1 0.9 1.9 -4.3 -4.6 -2.1 -0.0 0.9 2.3 -4.6 -3.6 1.3 -0.1 0.7 3.1
Trunk fat-free mass 0.4 2.3 8.2 -2.2 -0.4 1.1 1.6 1.6 -0.1 0.3 -0.9 -1.6 0.9 -2.5 1.1 -2.9 -0.9
Hip circumference 0.7 3.2 11.6 -1.1 1.8 -2.2 -2.1 -1.0 0.9 1.4 1.6 -3.4 -2.2 -0.7 1.3 -1.1 2.2
Time employed in main current job 0.9 1.1 5.3 0.5 -0.1 -0.5 -0.6 -0.9 -0.2 0.2 0.4 2.3 -0.8 0.8 0.2 1.0 2.3
Alcohol intake versus 10 years previously 0.5 0.8 2.3 0.8 -1.4 1.5 1.3 0.1 -0.4 0.0 -0.1 -0.8 0.6 1.3 0.5 1.1 -0.1
Father’s age at death 0.1 0.2 0.5 0.4 -0.2 0.3 0.3 -0.3 0.5 0.3 0.3 0.7 -0.6 0.2 0.4 0.0 0.4
Worrier / anxious feelings 3.7 7.0 20.9 1.4 -2.1 0.0 -0.2 3.1 -4.3 -4.4 -4.2 1.8 0.5 0.2 -4.6 1.1 -1.1
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 5.4 1.2 -2.2 1.6 1.3 1.2 -1.5 -2.1 -2.3 1.5 0.1 1.3 -2.1 1.7 0.1
Falls in the last year 1.0 1.3 3.8 0.4 -1.8 1.0 1.0 1.2 -1.2 -1.9 -1.5 1.2 -0.5 0.2 -1.6 0.1 -0.4
Hair/balding pattern: Pattern 3 0.4 0.6 1.7 -0.5 1.3 -0.7 -0.5 -0.3 1.2 1.0 1.2 -0.4 -0.1 -0.8 0.2 -0.9 0.1
Number of live births 1.0 1.4 3.8 -1.0 1.2 -1.3 -1.0 1.4 -0.6 -0.5 0.0 -0.7 0.3 -2.0 -0.7 -1.9 -1.8
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 7.5 -0.6 -1.4 1.7 1.9 2.7 -2.2 -1.8 -2.5 1.1 0.8 -1.1 -1.4 -0.5 -1.2
Pulse rate 1.0 1.8 4.1 1.9 -1.6 -0.1 -0.4 -0.5 -0.9 -1.8 -1.2 1.0 -0.3 2.0 -1.7 1.7 1.2
Happiness 1.6 1.9 5.9 0.8 -0.9 0.4 0.0 1.0 -1.8 -1.9 -2.4 2.1 0.0 0.8 -2.2 1.1 -0.2
Noisy workplace 0.1 0.2 1.3 0.2 -0.4 0.4 0.4 -0.3 -0.1 -0.1 -0.0 1.1 -0.0 0.4 -0.1 0.2 -0.4
Qualifications: A levels/AS levels or equivalent 4.0 9.0 32.9 0.1 -3.9 5.7 5.7 1.8 -0.1 -1.1 -2.8 3.2 3.6 0.5 0.3 0.6 -3.0
Serious illness, injury or assault of a close relative in last 2 years 2.9 3.3 7.2 -0.6 -2.2 2.4 2.7 2.4 -1.4 -1.8 -2.2 2.5 1.3 -0.5 -0.9 -0.3 -1.8
Mouth/teeth dental problems: Dentures 1.8 3.0 6.3 -0.4 1.9 -2.5 -2.4 -1.6 1.5 1.7 2.2 -1.1 -2.2 -0.4 0.8 -0.6 2.5
Asthma 0.3 0.5 1.4 0.3 0.3 -0.6 -0.8 -1.2 1.1 0.3 0.7 0.7 -1.1 0.9 0.3 0.6 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.4 0.4 -0.6 -0.8 -0.8 1.4 -1.6 -1.8 -1.1 1.0 0.5 0.0 -1.8 0.2 0.5
Medication: Cholesterol lowering 2.2 3.4 11.5 0.2 2.3 -3.3 -3.4 -1.6 0.3 0.8 1.5 -2.1 -3.0 -0.1 0.1 -0.5 0.6
Depression (self-reported) 0.9 1.1 4.2 -0.5 -1.5 2.0 2.0 1.2 -0.2 -0.3 -1.0 0.3 0.8 -0.2 -0.1 -0.1 -1.0
Medication: Lansoprazole 1.2 1.4 3.2 -0.6 0.9 -1.5 -1.3 1.4 -1.5 -1.2 -0.3 -0.2 0.4 -1.4 -1.5 -1.3 -1.8
Prospective memory result 1.3 1.5 5.7 -0.9 0.8 -1.1 -0.9 2.4 -1.7 -1.1 -1.0 2.1 0.2 -1.0 -1.2 -0.4 0.4
Lung cancer (father) 2.9 3.4 11.9 1.7 1.4 -1.0 -1.3 -2.6 1.9 1.8 1.9 -3.5 -0.8 1.5 1.9 1.2 1.7
Illnesses of mother 0.8 1.0 2.8 -1.0 -0.2 1.6 1.7 1.3 0.4 0.5 -0.2 0.7 1.2 -0.8 0.8 -1.1 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 11.8 -1.7 -0.8 1.1 1.5 3.4 -2.3 -1.4 -2.0 1.2 0.3 -2.2 -1.3 -1.4 -1.1
Pulse wave Arterial Stiffness index 1.0 1.2 3.7 -0.6 1.9 -1.3 -1.3 -1.0 1.1 1.4 1.2 0.4 -0.5 -0.3 1.1 0.2 1.6
Impedance of arm (left) 0.4 2.0 8.8 0.6 -0.8 1.2 0.9 0.5 -1.0 -1.4 -1.1 3.0 2.2 0.6 -1.6 0.9 -1.5
Arm fat mass (right) 1.3 5.6 21.6 0.0 2.0 -3.4 -3.5 -1.9 0.6 1.6 2.4 -4.7 -2.9 0.5 0.9 -0.3 2.8
Trunk predicted mass 0.4 2.4 8.1 -2.2 -0.4 1.1 1.7 1.6 -0.1 0.3 -0.9 -1.7 0.9 -2.5 1.1 -2.9 -0.9
Standing height 0.9 8.7 21.0 -3.1 -1.5 4.0 4.6 3.1 -0.2 -0.7 -2.4 1.8 4.3 -3.5 0.6 -3.5 -3.2
Length of working week for main job 0.5 0.6 1.8 -1.3 -0.2 0.7 0.9 0.5 -0.0 -0.3 -0.4 -0.5 0.4 -1.2 -0.1 -1.3 -1.1
Exposure to tobacco smoke at home 1.5 1.7 4.7 -1.6 0.4 1.2 1.3 1.1 0.3 0.5 -0.1 -0.9 1.2 -2.0 1.0 -2.2 -2.0
Breastfed as a baby 4.0 5.0 13.3 -2.0 -0.9 3.3 3.6 1.7 0.1 -0.4 -1.5 3.1 3.2 -2.0 -0.2 -1.7 -2.9
Tense / ‘highly strung’ 1.9 3.3 7.8 1.9 -1.9 0.5 0.3 1.8 -2.5 -2.7 -2.8 1.0 0.6 1.3 -2.8 1.8 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.7 13.7 -0.1 -2.1 0.8 0.8 2.9 -2.9 -3.3 -3.7 1.4 1.2 -0.1 -3.3 0.6 -2.1
Hair/balding pattern: Pattern 4 0.3 0.7 2.8 0.9 -0.5 -0.4 -0.4 -0.1 -0.1 0.3 0.6 -1.6 -1.5 0.5 0.6 0.5 1.7
Birth weight of first child 2.5 4.5 15.9 -1.6 -0.7 0.7 1.1 4.0 -2.5 -2.3 -2.4 0.2 0.3 -2.7 -2.5 -2.5 -2.3
Peak expiratory flow (PEF) 0.4 0.8 2.4 -1.2 0.2 -0.5 -0.2 1.6 -1.2 -0.7 -0.9 -0.0 -0.2 -1.4 -0.9 -1.4 0.0
Pulse wave reflection index 0.5 0.6 3.2 0.1 1.1 -1.1 -1.0 -0.2 -0.0 0.8 0.7 -1.8 -0.2 -0.4 0.5 -0.2 0.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.9 1.0 -0.9 1.0 0.7 0.4 -1.0 -0.9 -1.4 0.0 0.9 0.7 -0.9 0.7 -0.5
Loud music exposure frequency 0.6 0.6 1.8 0.0 0.5 0.2 0.1 -0.7 1.4 1.3 1.3 -0.5 -0.7 0.7 1.0 0.1 0.6
Qualifications: O levels/GCSEs or equivalent 2.4 3.8 18.1 -0.9 -2.7 4.2 4.2 1.1 0.2 -0.0 -1.4 2.2 0.8 -0.3 0.4 -0.1 -0.8
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 6.4 1.7 -0.7 -1.4 -1.8 -0.6 -1.7 -1.3 -0.6 0.5 -2.5 1.6 -1.4 1.8 1.5
Blood clot in the leg (DVT) 0.4 0.5 1.3 0.2 -1.1 0.1 0.0 0.2 -0.7 -1.2 -0.6 0.6 -0.9 0.3 -0.7 0.5 0.9
Medication: Paracetamol 1.6 2.7 8.4 0.8 -2.1 0.0 -0.1 1.4 -2.3 -2.9 -2.0 0.9 -1.3 0.8 -2.9 0.8 -0.7
Headache pain in last month 5.7 10.1 23.8 0.9 -3.3 1.3 1.2 4.3 -4.4 -4.8 -4.9 3.8 -0.8 0.5 -4.7 1.3 -1.2
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 9.1 -0.3 -1.9 2.9 3.0 0.7 0.4 -0.2 -0.7 1.4 2.4 0.2 0.4 0.5 0.0
Glaucoma (self-reported) 0.6 0.7 4.1 -0.9 0.7 -0.0 0.2 0.6 -0.5 -0.4 -0.3 -0.1 0.3 -1.5 -0.3 -1.3 -2.0
Gout (self-reported) 1.8 2.5 7.8 -1.5 1.6 0.6 0.5 -1.2 2.7 2.8 2.2 0.1 0.4 -0.4 2.8 -0.7 -0.0
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 11.3 -0.1 -1.8 3.3 3.4 1.5 -0.1 -0.6 -1.2 1.7 2.0 -0.0 0.7 0.2 -1.4
Medication: Amlodipine 0.8 1.1 4.6 0.4 1.5 -1.9 -2.1 -0.4 -0.2 0.3 0.5 -2.1 -0.6 0.1 -0.3 0.0 0.1
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.5 0.1 0.6 -0.7 -0.9 -1.1 0.8 0.5 0.9 -1.2 -0.9 0.5 0.6 0.6 1.1
Birth weight 1.8 4.0 12.1 -2.0 -0.8 2.4 2.9 3.5 -1.1 -1.2 -1.4 -0.1 2.7 -2.3 -0.3 -2.1 -2.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.3 0.6 -0.1 -0.4 -0.4 -1.1 0.2 0.0 0.2 -0.0 -0.3 0.5 -0.1 0.3 0.5
High blood pressure (siblings) 0.9 1.3 4.5 -0.1 1.2 -2.1 -1.9 -0.6 0.5 0.5 0.8 -1.9 -0.7 -0.6 0.0 -1.2 -1.1
Forced vital capacity (FVC), Best measure 1.4 5.3 19.2 -1.8 -1.3 1.6 2.0 4.4 -2.9 -2.2 -2.8 1.7 0.9 -2.5 -1.8 -1.7 -2.4
Body fat percentage 2.6 10.6 26.6 0.5 3.1 -4.9 -5.2 -3.3 1.4 2.4 3.7 -4.7 -4.0 1.3 1.3 0.5 3.7
Leg fat percentage (right) 3.2 11.8 35.5 1.3 2.7 -5.7 -6.0 -3.1 0.6 1.4 3.3 -4.8 -4.9 1.7 0.4 0.8 3.8
Arm fat-free mass (right) 0.4 2.3 7.8 -2.0 0.9 -0.1 0.3 -0.1 1.3 1.8 0.8 -2.8 -0.6 -1.8 2.3 -2.4 0.5
Exposure to tobacco smoke outside home 0.4 0.5 1.8 0.8 -0.5 0.1 0.1 0.0 -0.0 -0.6 -1.3 1.3 -0.4 0.3 -0.8 0.3 -1.1
Comparative body size at age 10 0.3 0.8 8.6 -0.2 0.0 0.5 0.5 0.3 0.3 0.3 0.2 -2.9 -0.6 -0.5 -0.0 -1.0 -0.1
Number of full brothers 0.5 0.7 2.5 0.2 -0.8 -0.2 -0.3 0.4 -1.1 -1.6 -1.3 -0.6 -0.1 0.1 -1.4 0.2 -0.7
Worry too long after embarrassment 2.8 4.7 11.6 -0.6 -2.1 2.1 2.2 2.5 -2.0 -2.5 -3.4 1.8 2.7 -1.3 -2.4 -1.0 -2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 4.3 5.5 11.5 -0.7 -2.6 3.3 3.2 3.4 -1.8 -2.2 -3.3 2.1 2.5 -0.7 -1.7 -0.3 -2.1
Wheeze or whistling in the chest in last year 1.2 2.2 8.0 2.6 -1.4 -0.3 -0.8 -1.5 -0.1 -0.8 -0.1 0.5 -1.2 2.8 -0.6 2.6 1.0
Number of children fathered 0.4 0.4 1.3 -0.3 0.9 0.0 0.1 0.1 0.5 0.9 1.0 0.7 0.1 -0.6 1.2 -0.6 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.6 -0.8 0.7 -0.6 -0.5 0.7 -0.2 0.6 0.5 -0.4 -0.8 -1.1 0.3 -1.3 0.2
Age at first live birth 2.2 3.9 9.7 -2.1 -0.9 2.7 3.1 1.7 0.1 -0.4 -1.4 3.1 2.9 -1.8 0.1 -1.2 -2.3
Pulse wave peak to peak time 1.6 1.9 5.2 0.3 -2.3 1.7 1.8 1.5 -1.4 -1.6 -1.5 -0.1 0.6 -0.1 -1.2 -0.6 -2.0
Health satisfaction 1.6 2.1 8.1 -0.2 1.2 -2.7 -2.9 -0.3 -1.0 -1.1 -0.4 1.0 -1.9 -0.2 -2.1 0.3 1.0
Shortness of breath walking on level ground 2.6 3.1 6.8 1.8 -0.1 -2.4 -2.6 -1.6 -0.3 -1.0 -0.6 -0.9 -2.6 2.2 -1.7 2.1 2.0
Qualifications: College or University degree 2.9 9.4 29.1 -1.9 -3.4 4.9 5.4 2.9 -0.8 -1.5 -2.8 3.7 3.5 -1.2 -0.4 -1.3 -3.9
Eye problems/disorders: None of the above 0.1 0.2 0.5 0.4 -0.7 0.4 0.3 -0.4 -0.1 -0.2 -0.1 -0.3 -0.4 0.4 -0.2 0.4 0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.0 3.6 0.0 1.1 -1.5 -1.4 -0.5 0.5 0.6 1.1 -1.2 -1.9 -0.3 0.3 -0.6 0.9
Emphysema/chronic bronchitis 0.3 0.4 1.6 1.3 -0.2 0.1 -0.2 -1.0 -0.2 -0.4 -0.4 0.3 0.7 0.8 -0.2 0.9 0.3
Medication for pain relief, constipation, heartburn 1.3 2.2 7.1 -1.1 -0.4 2.4 2.7 0.2 1.7 1.6 0.2 -0.1 1.8 -0.6 2.1 -0.7 -1.5
Neck or shoulder pain in last month 0.2 0.2 1.1 -0.4 1.0 -0.1 -0.3 0.4 0.2 0.5 0.9 0.6 0.4 -0.3 0.5 -0.1 0.1
Medication: Blood pressure 1.2 2.1 6.4 1.3 0.6 -2.3 -2.5 -0.5 -1.6 -0.9 -0.7 -1.7 -2.5 0.6 -1.3 0.5 0.0
Angina (self-reported) 0.5 0.7 2.0 0.0 1.4 -0.9 -1.2 -1.0 0.3 0.9 1.1 0.4 -1.0 0.1 0.8 0.1 0.9
Migraine (self-reported) 4.8 6.0 13.7 1.7 -3.4 1.6 1.4 2.7 -3.6 -3.7 -3.5 1.9 0.5 1.3 -3.0 1.6 -1.2
Medication: Ibuprofen 1.3 1.6 4.5 0.7 -0.9 -0.3 -0.3 2.0 -2.0 -2.1 -1.7 1.4 0.8 -0.0 -1.9 0.4 0.1
Medication: Allopurinol 2.6 3.4 10.1 -1.3 1.7 0.1 -0.0 -1.7 2.6 3.0 3.0 -1.7 0.3 -0.6 3.2 -1.1 0.1
Medication: Omeprazole 2.1 2.5 5.6 2.1 0.4 -2.0 -2.4 -1.8 -0.3 -0.8 0.5 -1.6 -1.8 1.9 -0.8 1.9 1.5
Medication: Seretide 50 evohaler 0.9 1.0 2.7 0.8 -1.3 0.0 -0.0 0.6 -1.3 -1.6 -1.4 1.4 -0.3 0.6 -1.5 0.7 -0.6
Mean time to correctly identify matches 0.8 1.6 4.5 0.9 0.3 1.5 1.2 -1.5 2.1 2.1 1.4 -0.6 -0.2 0.7 1.9 0.5 -0.1
Heart disease (mother) 1.1 1.3 3.6 -0.4 1.7 -0.9 -0.9 -1.3 1.6 1.5 1.9 -1.0 -0.5 -0.1 1.4 -0.1 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.0 3.6 10.9 3.1 -0.6 -1.2 -1.8 -2.0 -0.4 -0.6 -0.4 -1.4 -1.1 3.2 -0.8 3.3 2.3
Whole body fat mass 1.8 7.8 22.9 -0.2 2.7 -4.1 -4.2 -2.4 1.2 2.2 3.1 -4.8 -3.5 0.3 1.4 -0.5 2.9
Leg fat mass (right) 2.0 7.8 24.3 0.2 2.3 -4.5 -4.5 -1.9 0.5 1.4 2.7 -4.9 -4.0 0.5 0.8 -0.4 2.9
Arm predicted mass (right) 0.6 2.9 7.5 -2.4 1.2 -0.1 0.4 0.0 1.4 2.1 1.0 -2.6 -0.7 -2.2 2.5 -2.7 0.3
Pulse rate, automated reading 0.6 1.9 4.8 1.9 -0.8 -0.9 -1.4 -1.6 -0.2 -0.7 -0.0 -1.1 -1.9 2.2 -1.2 1.6 1.7
Alcohol intake frequency. 0.1 0.2 1.0 -0.3 -0.1 -0.1 -0.1 0.5 -0.5 -0.6 -0.6 -0.6 -0.1 -0.3 -1.0 0.4 -0.5
Comparative height size at age 10 0.6 3.4 8.1 -2.1 -0.4 2.4 2.9 0.5 2.0 1.5 -0.2 0.9 2.3 -2.1 2.4 -2.5 -0.7
Number of full sisters 0.3 0.4 1.7 -0.3 -0.5 0.6 0.7 -0.2 0.8 0.4 0.1 -1.3 0.9 0.0 0.6 -0.4 -0.0
Suffer from ‘nerves’ 2.4 3.9 14.2 1.2 -1.3 -1.0 -1.1 1.6 -3.3 -3.1 -3.2 0.5 -0.5 0.1 -3.8 0.7 0.2
Overall health rating 1.5 3.4 13.2 0.2 1.3 -3.4 -3.6 -0.7 -0.7 -0.8 0.4 -0.2 -3.6 0.2 -1.8 0.3 1.5
Chest pain or discomfort 0.8 1.1 2.5 1.6 -1.5 -0.4 -0.4 0.4 -1.3 -1.5 -1.5 0.2 -1.0 0.9 -1.4 0.9 0.2
Had major operations 1.1 1.3 3.9 -1.3 1.8 -1.6 -1.2 0.0 0.0 -0.1 0.8 1.1 -0.6 -2.0 -0.2 -1.6 0.6
Age at last live birth 2.9 4.3 11.1 -1.7 -0.9 2.8 3.0 2.1 -0.6 -0.8 -1.9 3.3 3.0 -1.5 -0.5 -1.0 -2.7
Family relationship satisfaction 0.2 0.3 1.1 0.5 -0.0 0.4 0.1 -0.4 0.5 0.0 -0.5 0.6 1.0 1.1 -0.1 0.8 0.0
Leg pain on walking 2.5 3.1 8.0 1.0 1.3 -2.6 -2.8 -2.1 0.2 0.4 1.2 -2.4 -2.8 1.2 -0.5 0.9 2.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 3.4 -0.2 -1.3 1.7 1.8 1.6 -0.0 -0.1 -0.8 0.1 -0.1 -0.2 -0.1 0.0 -1.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 0.5 0.2 -0.1 -0.2 -0.5 0.6 0.8 0.9 0.2 0.8 0.3 1.1 0.1 -0.3
Illness, injury, bereavement, stress in last 2 years 2.6 3.1 7.0 1.0 2.3 -2.3 -2.6 -2.6 1.0 1.7 2.0 -2.6 -0.6 0.4 0.8 0.3 1.7
Medication: Aspirin 2.4 3.2 8.1 -0.9 2.8 -2.2 -2.4 -1.6 1.6 1.9 2.3 -0.4 -1.6 -0.9 1.2 -0.7 2.3
Supplements: Vitamin C 0.5 0.6 1.8 0.0 0.5 1.1 1.0 -0.3 0.9 1.1 0.8 1.3 0.0 0.1 1.1 -0.1 -1.0
Knee pain experienced in last month 1.6 2.5 8.4 1.2 1.0 -2.7 -2.9 -1.0 -0.5 -0.3 0.7 -1.9 -2.6 1.0 -0.7 0.7 1.9
Hypertension (Self-reported) 1.5 4.2 15.6 0.2 1.8 -3.8 -3.9 -0.6 -1.2 -0.3 0.6 -2.8 -3.2 -0.3 -1.3 -0.5 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.5 1.2 0.5 -1.5 -1.7 -0.8 -0.6 -0.8 0.0 -1.9 -1.5 1.3 -0.6 1.3 0.3
Illnesses of father: Heart disease 0.3 0.4 2.0 -0.2 0.9 -0.6 -0.7 0.1 -0.2 0.5 0.2 0.9 0.2 0.0 -0.1 0.1 1.4
Illnesses of siblings: Diabetes 0.9 1.1 3.7 -0.5 1.2 -0.5 -0.5 -0.6 1.0 1.7 1.9 -0.9 -0.4 -0.2 1.7 -0.9 1.1
Smoking status: Previous 1.9 2.8 7.4 2.3 0.0 -0.8 -1.4 -2.4 1.3 0.4 1.0 -0.9 -2.0 2.7 0.1 2.4 2.2
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.9 8.3 -1.4 -1.7 2.6 2.9 2.5 -1.0 -1.5 -2.6 1.4 2.0 -1.8 -1.1 -1.5 -2.3
Whole body fat-free mass 0.3 2.0 6.7 -2.1 -0.2 0.8 1.3 1.0 0.3 0.8 -0.3 -2.3 0.3 -2.1 1.6 -2.6 -0.3
Leg fat-free mass (right) 0.4 1.9 6.7 -2.0 0.0 0.9 1.2 0.6 0.5 1.2 0.1 -2.6 0.2 -1.8 1.8 -2.2 0.3
Arm fat percentage (left) 1.9 8.0 21.0 0.9 2.2 -4.3 -4.6 -2.6 0.5 1.5 2.7 -4.5 -3.9 1.5 0.6 0.8 3.4
Average weekly red wine intake 0.4 0.5 2.6 0.1 -0.4 0.7 0.8 -0.2 0.9 0.9 0.4 -0.7 -1.6 0.2 0.9 -0.1 0.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.1 -0.3 0.2 0.4 0.6 1.4 -0.9 0.0 0.1 1.1 0.8 -1.0 0.5 -1.1 -0.0
Mood swings 3.4 6.2 15.9 0.7 -2.1 1.3 1.2 3.4 -4.0 -3.7 -3.8 1.9 0.9 -0.5 -3.6 0.2 -2.2
Loneliness, isolation 2.9 4.1 11.8 3.2 -1.8 -0.1 -0.7 -0.2 -2.3 -2.3 -2.1 0.8 -0.1 2.9 -2.5 3.4 0.9
Long-standing illness, disability or infirmity 1.2 1.8 4.1 1.6 -1.3 -0.1 -0.6 0.1 -1.4 -2.0 -1.7 1.0 -1.2 1.6 -1.9 1.6 0.4
Ever had bowel cancer screening 0.9 1.0 3.7 0.5 0.7 -0.8 -1.0 -1.0 0.8 0.9 1.3 0.3 -1.2 0.9 0.8 1.0 1.9
Diabetes diagnosed by doctor 1.3 2.2 9.7 -0.4 0.2 -1.8 -1.7 0.2 -1.8 -1.1 0.1 -2.2 -3.1 -0.9 -1.6 -1.1 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 4.5 -0.7 -0.0 1.0 1.0 2.1 -0.8 -1.0 -1.3 0.9 2.1 -1.2 -0.9 -1.1 -2.1
Friendships satisfaction 0.7 0.8 4.0 -1.2 2.0 -0.8 -0.8 -0.3 0.8 0.7 0.6 0.2 0.3 -1.2 0.1 -1.2 -0.7
Qualifications: nursing, teaching 1.8 2.9 9.0 -0.5 -1.4 2.8 2.8 0.6 0.4 -0.3 -1.4 2.9 3.0 0.0 0.8 0.1 -1.2
Commuting to job workplace: Walk 2.8 3.0 9.4 0.8 -1.5 -0.3 -0.3 1.2 -3.0 -3.0 -3.1 0.9 0.7 0.5 -2.8 1.0 -0.5
Eye problems/disorders: Cataract 0.3 0.4 1.0 0.5 0.0 -0.7 -0.8 1.0 -0.8 -0.7 -0.6 -0.2 -0.4 0.1 -0.8 -0.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 10.4 2.6 -1.3 -0.2 -0.6 -1.7 0.4 -0.2 0.4 -0.2 -1.3 3.2 0.0 3.2 1.6
Medication for cholesterol 2.0 3.0 11.7 -0.4 -1.5 2.5 2.9 1.9 0.4 -0.3 -1.4 0.6 2.2 -0.8 0.6 -0.9 -3.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.5 0.1 1.2 -0.4 -0.5 -1.5 2.1 2.0 1.8 -1.8 -0.2 0.7 1.8 -0.3 1.4
Back pain experienced in last month 0.4 0.6 2.9 -0.5 -0.1 -0.2 -0.1 1.7 -1.2 -1.0 -0.7 1.0 -0.1 -0.7 -1.0 -0.5 0.5
Mineral and other dietary supplements 0.9 1.3 4.6 -1.9 0.4 0.6 0.9 1.2 0.3 -0.1 -0.2 -0.7 2.1 -1.6 -0.0 -1.5 -1.2
Breast cancer (self-reported) 2.7 3.2 13.7 -2.5 1.4 -0.7 -0.0 2.1 0.2 0.2 -0.1 -0.6 -0.1 -3.1 -0.1 -3.7 -2.9
Asthma (self-reported) 0.4 0.7 2.1 0.5 0.2 -0.7 -0.9 -1.3 1.1 0.2 0.7 0.7 -1.4 1.1 0.4 0.8 0.9
Osteoporosis (self-reported) 0.3 0.4 1.3 0.2 -0.3 1.1 1.1 0.0 0.8 0.2 0.2 -0.7 0.6 -0.0 0.5 -0.2 -1.0
Osteoarthritis (self-reported) 1.1 1.4 3.2 0.0 1.3 -1.1 -1.2 -1.1 1.3 1.5 1.8 0.4 -1.5 0.2 1.1 -0.2 1.7
Medication: Aspirin 1.7 2.3 6.0 -0.8 2.4 -1.9 -2.1 -1.3 1.3 1.6 2.0 -0.6 -1.2 -0.8 0.9 -0.7 1.9
Medication: Gliclazide 0.7 0.7 3.8 0.3 -1.2 0.1 0.1 0.1 -0.6 -0.7 0.1 -2.0 -1.8 -0.1 -0.4 -0.7 -0.6
Illnesses of father: None of the above (group 1) 0.4 0.5 1.7 0.5 -1.1 0.9 0.9 0.4 -0.1 -0.7 -0.4 1.0 -0.3 0.4 -0.4 0.2 -1.3
Smoking status: Current 0.6 0.9 3.5 0.4 0.8 0.2 -0.2 -1.9 1.7 0.9 0.7 -0.6 0.6 1.1 0.7 1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.8 -0.1 -0.1 0.3 0.4 1.1 -1.0 0.4 0.1 1.7 -0.7 0.1 0.5 0.5 0.5
Whole body water mass 0.3 2.0 6.8 -2.1 -0.1 0.8 1.2 1.1 0.2 0.8 -0.3 -2.5 0.3 -2.2 1.5 -2.6 -0.2
Leg predicted mass (right) 0.4 1.9 6.9 -2.1 0.1 0.7 1.1 0.7 0.4 1.1 0.1 -2.6 0.1 -1.9 1.8 -2.2 0.2
Arm fat mass (left) 1.4 5.7 21.0 -0.1 2.0 -3.4 -3.5 -2.0 0.8 1.7 2.3 -4.6 -3.0 0.5 1.0 -0.3 2.8
Number of self-reported non-cancer illnesses 1.0 1.7 6.8 1.4 -0.8 -0.7 -1.1 -0.8 -0.5 -0.8 -0.3 1.5 -2.6 1.6 -1.0 1.8 1.6
Average weekly champagne plus white wine intake 0.8 1.2 2.4 0.2 -0.9 1.2 1.2 1.2 -1.2 -1.4 -1.5 1.6 1.4 -0.0 -0.8 0.2 -0.8
Miserableness 1.3 2.3 5.6 1.0 -1.5 0.9 0.7 1.8 -2.2 -2.3 -2.4 0.7 -0.0 0.7 -2.3 1.1 -0.7
Guilty feelings 2.2 3.3 8.3 1.0 -1.9 0.9 0.9 1.9 -2.4 -2.6 -2.9 1.4 2.2 0.4 -2.5 0.7 -1.4
Wears glasses or contact lenses 0.7 0.8 1.9 -0.9 0.6 -0.4 -0.0 -0.2 1.2 1.0 1.4 -0.5 -0.9 -1.1 1.1 -1.2 0.6
Ever taken oral contraceptive pill 1.5 1.7 4.9 -0.0 -1.4 1.6 1.6 1.4 -1.2 -1.5 -2.2 1.0 1.6 -0.3 -1.3 0.1 -0.8
Hearing aid user 0.2 0.2 0.7 -0.7 0.4 0.1 0.2 0.2 0.3 0.6 0.7 -0.0 -0.7 -0.5 0.8 -0.5 -0.0
Mother’s age at death 0.8 1.0 3.0 -0.2 -0.6 1.7 1.6 0.9 -0.2 -0.4 -0.5 1.7 1.4 -0.0 -0.2 -0.1 -1.2
Financial situation satisfaction 2.0 2.4 5.7 2.4 -0.8 -1.3 -1.8 -0.6 -1.5 -1.4 -1.2 -0.4 -1.5 2.3 -1.9 2.0 1.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 -0.9 0.2 0.6 0.9 0.7 0.2 0.5 0.3 0.3 -0.4 -1.1 0.6 -1.1 -1.1
Commuting to job workplace: Public transport 1.2 1.5 5.5 0.3 -1.8 2.4 2.3 0.7 -0.5 -0.9 -1.4 1.1 1.0 0.4 -0.7 0.7 -0.4
Eye problems/disorders: Glaucoma 0.4 0.4 2.2 -0.7 0.7 -0.1 0.1 0.2 0.2 0.0 0.1 -0.1 0.7 -1.1 0.2 -1.0 -1.5
Medication: Blood pressure 1.2 2.3 9.7 0.4 1.4 -2.9 -3.1 -1.3 -1.0 0.0 1.0 -0.8 -1.9 0.4 -0.4 0.2 2.0
Pain type(s) experienced in last month: Hip pain 1.7 2.1 5.4 2.0 -1.7 -0.6 -0.9 0.5 -2.2 -1.6 -1.2 0.7 -2.3 1.3 -1.6 1.2 1.1
Supplements: Fish oil (including cod liver oil) 0.9 1.1 2.8 1.7 0.4 -1.0 -1.3 -1.4 -0.0 0.3 0.4 1.4 -1.1 1.3 0.1 1.4 1.2
High cholesterol (Self-reported) 1.7 3.0 6.3 0.6 1.9 -2.2 -2.5 -2.1 1.2 1.7 2.2 -1.6 -2.1 0.8 0.9 0.4 2.0
Medication: Bendroflumethiazide 0.7 1.1 2.9 -0.2 1.7 -1.2 -1.3 -1.0 1.4 1.4 1.4 -0.6 -0.5 -0.2 1.3 -0.5 -0.2
Medication: Paracetamol 1.1 1.8 5.8 0.1 -1.9 0.6 0.6 1.4 -1.8 -2.4 -1.7 0.7 -1.1 0.4 -2.1 0.6 -0.5
Medication: Lisinopril 1.7 2.2 8.0 0.9 1.3 -2.6 -2.8 -0.2 -1.3 -0.6 0.1 -2.4 -1.7 -0.0 -1.4 -0.2 -0.2
Medication: Atorvastatin 1.7 2.1 5.4 -0.2 0.7 -0.5 -0.5 -1.3 2.1 1.9 1.9 -2.2 -2.3 0.1 1.4 -0.5 1.6
Illnesses of father: High blood pressure 0.9 1.2 3.6 0.0 -0.3 -0.7 -0.6 1.2 -1.6 -1.9 -1.8 1.2 0.7 -0.2 -1.6 0.5 0.3
Alcohol drinker status: Never 0.2 0.2 0.7 -0.2 -0.3 0.9 0.7 0.7 -0.2 0.1 -0.2 0.2 0.5 0.2 -0.1 0.4 -0.4
Ever smoked 0.7 1.2 3.8 0.8 0.8 -0.3 -0.8 -1.9 1.5 0.7 0.8 -0.2 -0.4 1.4 -0.1 1.6 1.7
Basal metabolic rate 0.3 1.9 8.3 -2.0 0.4 0.0 0.5 0.6 0.4 1.0 0.2 -2.9 -0.2 -2.0 1.6 -2.5 0.3
Leg fat percentage (left) 2.9 10.7 28.8 1.0 2.7 -5.1 -5.4 -3.1 1.0 2.0 3.5 -4.7 -4.3 1.5 1.1 0.8 3.9
Arm fat-free mass (left) 0.4 2.1 7.7 -2.1 0.5 -0.1 0.4 0.6 0.7 1.2 0.4 -2.8 -0.2 -2.1 1.8 -2.7 0.2
Number of operations (self-reported) 0.4 0.6 1.3 -0.2 0.6 -1.0 -0.8 0.6 -0.6 -0.8 0.0 1.1 -0.2 -1.1 -1.1 -0.9 -0.2
Average weekly beer plus cider intake 0.7 1.0 4.3 0.9 -0.1 -1.7 -1.6 -0.8 -0.0 -0.5 0.3 -0.8 -2.1 0.8 -0.6 0.7 0.9
Irritability 0.6 1.0 3.8 0.0 0.1 -0.6 -0.8 1.2 -1.8 -1.6 -1.2 0.4 0.7 -0.3 -1.9 0.4 -0.2
Risk taking 1.8 2.6 7.1 1.5 -2.7 2.3 2.2 -0.2 -0.8 -1.2 -1.3 1.9 0.6 1.9 -0.5 2.0 0.7
Ever had prostate specific antigen (PSA) test 0.3 0.3 2.7 0.0 -0.0 0.6 0.6 0.1 0.7 0.4 -0.2 1.6 -0.6 -0.3 0.2 0.3 0.0
Fractured/broken bones in last 5 years 2.2 2.8 6.3 -0.1 1.8 -1.1 -1.3 -2.4 2.4 2.1 2.5 -0.2 0.3 0.2 2.2 0.4 2.3
Age started oral contraceptive pill 2.6 3.3 9.1 -0.2 2.2 -0.2 -0.2 -2.0 3.0 3.0 2.6 -0.7 0.9 0.1 3.0 -0.7 1.3
Diastolic blood pressure, automated reading 1.3 4.2 18.7 0.7 2.3 -4.1 -4.3 -2.1 0.1 0.4 1.2 -1.8 -1.5 0.4 -0.9 0.3 2.0
Ever depressed for a whole week 1.9 2.4 6.1 -1.1 -1.1 1.4 1.5 2.1 -1.4 -1.8 -2.5 1.3 1.0 -1.1 -1.6 -0.9 -1.8
Unable to work because of sickness or disability 0.5 0.6 3.5 -0.5 0.4 -0.4 -0.5 -0.7 1.4 0.6 0.4 -0.4 -0.9 0.6 0.4 0.5 1.9
Commuting to job workplace: Cycle 1.5 1.8 5.4 -0.5 0.2 2.0 2.0 -0.6 1.9 1.9 0.9 0.2 1.8 -0.1 2.3 -0.3 0.3
Myopia 0.2 0.3 1.1 0.3 -0.7 0.2 0.2 -0.9 0.4 0.0 0.7 -1.1 -0.1 0.6 0.3 0.2 -0.3
Vascular/heart problems diagnosed by doctor 1.0 2.7 11.0 0.0 -1.9 3.1 3.3 0.6 0.9 -0.1 -0.4 1.8 2.2 0.1 0.9 0.1 -1.7
Cholesterol lowering medication 0.8 1.2 7.4 0.2 0.6 -1.0 -1.2 -1.2 0.6 0.8 1.1 -0.8 -1.1 0.6 0.4 0.7 2.7
Medication: Omeprazole (e.g. Zanprol) 0.9 1.0 3.8 1.2 0.7 -1.8 -1.9 -0.9 -0.4 -0.6 0.5 -1.2 -1.0 0.8 -0.6 0.7 0.5
Pain experienced in last month 0.8 1.4 3.9 -1.0 -0.1 1.1 1.5 -0.7 1.5 1.4 0.5 -1.3 0.8 -0.9 2.0 -1.2 -1.0
Supplements: Calcium 1.0 1.1 6.0 1.1 0.2 -1.3 -1.4 -0.7 0.3 0.2 0.9 -1.2 -2.5 1.0 0.0 0.4 0.4
Basal cell carcinoma (self-reported) 0.4 0.5 1.2 0.8 -0.4 1.1 1.1 0.3 0.5 0.4 -0.3 1.1 0.7 0.4 0.7 0.5 -0.4
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.6 0.4 -0.3 -0.9 -1.0 0.9 -1.2 -1.2 -0.6 0.6 -0.8 0.1 -1.2 0.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.8 0.0 -1.1 0.0 0.0 0.2 -0.6 -1.1 -0.6 0.5 -1.4 0.1 -0.8 0.3 1.0
Heart disease (siblings) 0.2 0.3 0.9 0.5 0.4 -0.9 -0.9 -0.4 0.7 0.2 0.3 -0.6 -0.2 0.4 0.1 0.2 0.6
Alcohol drinker status: Previous 0.6 0.7 2.5 1.3 -1.1 0.3 0.1 -0.7 0.2 -0.8 -0.8 -0.9 0.3 1.4 -0.4 1.6 -0.2
Pack years of smoking 2.1 3.1 7.5 -0.8 2.5 -2.7 -2.5 -1.4 1.1 1.7 1.9 -2.5 -1.3 -1.0 0.7 -1.5 0.7
Impedance of whole body 0.3 1.7 9.6 0.5 -0.5 0.6 0.4 0.4 -0.9 -1.5 -1.1 3.1 1.8 0.4 -1.7 0.8 -1.5
Leg fat mass (left) 1.9 7.4 24.4 0.1 2.3 -4.2 -4.2 -2.0 0.7 1.7 2.8 -4.9 -3.6 0.5 1.1 -0.3 2.9
Arm predicted mass (left) 0.4 1.9 6.9 -2.0 0.6 -0.2 0.3 0.5 0.6 1.2 0.2 -2.6 -0.1 -2.0 1.7 -2.5 0.2