Hub : Genes

MTCH2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.03 0.019 3.9e-03 -0.002 0.002 -0.001 0.003 -0.002 7.3e-01 1.6e-01 5.0e-01 1.1e-01 8.6e-01
2 GTEx Brain Cortex 0.21 0.086 1.8e-03 0.188 NA 0.154 NA 0.158 6.9e-06 NA 5.0e-05 NA 4.0e-05
3 GTEx Esophagus Muscularis 0.09 0.038 6.9e-04 0.035 NA 0.012 NA 0.021 3.3e-03 NA 6.0e-02 NA 1.8e-02
4 GTEx Muscle Skeletal 0.05 0.019 1.2e-04 0.032 NA 0.037 NA 0.030 4.2e-04 NA 1.5e-04 NA 5.6e-04
5 GTEx Testis 0.17 0.055 9.0e-07 0.160 NA 0.162 NA 0.163 1.3e-07 NA 1.2e-07 NA 1.0e-07
6 NTR Blood 0.02 0.008 1.8e-07 0.036 0.022 0.034 0.026 0.035 9.6e-12 8.0e-08 4.0e-11 8.0e-09 1.3e-11
7 ROSMAP Brain Pre-frontal Cortex 0.35 0.076 0.0e+00 0.401 0.367 0.405 0.404 0.398 3.3e-55 1.8e-49 4.7e-56 7.1e-56 9.5e-55

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Alzheimer’s Disease (in mother) 0.9 1.1 2.7 0.7 -1.0 -1.7 -1.0 -1.3 0.6 -0.6
Alzheimer’s Disease (in father) 1.1 1.2 3.3 -1.8 -1.2 -1.0 -1.0 -0.5 0.8 -0.9
Alzheimer’s Disease (including proxy) 10.1 14.2 22.9 -2.1 -3.8 -4.8 -3.7 -3.8 3.8 -3.8
Crohns Disease (2017) 0.7 1.5 2.5 -1.1 -1.5 -0.8 -1.6 -1.0 1.1 -1.2
Irritable Bowel Disease (IBD) 0.7 1.6 3.0 -1.6 -1.7 -0.7 -1.3 -1.4 0.9 -1.0
Ulcerative Colitis (UC) 0.5 0.9 2.0 -1.2 -1.4 -0.5 -1.0 -1.0 0.5 -0.6
Major Depression (MDD) 5.4 6.6 9.5 -3.1 -2.8 -2.7 -1.8 -2.6 2.4 -2.4
Reaction Time 0.5 0.9 2.4 1.6 0.3 1.3 -0.1 -0.9 -0.9 0.9
Verbal and Numeric Reasoning (VNR) 10.6 25.7 31.5 -3.7 -5.4 -4.5 -5.6 -4.9 5.5 -5.6
Breast Cancer 0.4 0.9 3.8 0.2 -0.8 -1.9 -0.8 -1.0 0.6 -0.4
Ovarian Cancer 0.3 0.4 1.3 -0.4 0.4 1.2 -0.0 0.7 -0.5 0.4
Prostate Cancer 5.6 7.9 12.3 -0.8 -2.2 -3.5 -3.2 -3.2 2.9 -2.9
Age at First Birth 0.6 0.8 1.7 1.3 0.9 0.9 0.9 0.6 -0.9 0.9
Bipolar Disorder 2.2 2.2 4.6 -0.2 -2.1 -1.4 -1.8 -1.1 1.5 -1.4
Body Mass Index (BMI) (2010) 19.8 27.7 33.8 3.9 4.5 5.8 5.6 5.4 -5.6 5.8
Coronary Artery Disease (CAD) 0.5 0.6 1.5 1.2 0.6 0.4 0.5 0.8 -0.6 0.8
Crohns Disease (2012) 3.0 4.9 5.5 2.0 2.2 2.0 2.3 2.2 -2.3 2.3
Mean Putamen Volume 2.0 2.3 4.9 2.2 1.1 1.0 1.2 1.1 -1.7 1.8
Fasting Glucose 1.6 1.9 7.7 1.0 0.5 2.8 0.1 1.4 -1.2 1.1
HbA1C 0.8 0.9 1.7 -0.8 -0.9 -0.8 -1.1 0.4 1.1 -1.3
HDL Cholesterol 21.2 34.9 62.1 -3.1 -6.9 -4.3 -7.9 -5.3 6.2 -6.2
LDL Cholesterol 1.1 1.7 2.9 0.4 -1.7 -1.3 -1.6 -0.6 1.4 -1.4
Lupus 1.8 2.8 4.0 -1.7 -1.7 -1.0 -1.6 -1.4 2.0 -2.0
Neuroticism 13.8 20.2 30.1 -4.6 -4.0 -5.5 -3.5 -4.2 4.7 -4.7
Primary Biliary Cirrhosis 2.2 3.1 4.5 -1.7 -1.6 -1.4 -1.7 -1.6 2.1 -2.1
Rheumatoid Arthritis 3.6 4.9 5.7 1.8 2.4 2.3 2.1 2.1 -2.4 2.3
Schizophrenia 1.0 2.3 4.7 -1.0 -1.7 -1.7 -1.1 -2.2 1.5 -1.2
Triglycerides 1.0 1.6 3.6 0.5 0.9 0.7 1.9 1.6 -1.3 1.2
Type 2 Diabetes (T2D) 0.2 0.3 0.7 0.8 0.3 0.0 0.2 0.3 -0.6 0.7
Ulcerative Colitis 2.9 4.2 7.9 2.8 2.3 1.6 1.6 2.2 -1.8 1.8
Blood Eosinophil Count 1.1 8.9 16.0 3.2 4.0 0.2 3.0 2.1 -3.3 3.4
Blood Platelet Count 6.6 77.1 98.6 -9.3 -7.3 -7.7 -7.7 -9.9 9.3 -9.8
Blood Red Count 1.6 15.3 28.9 2.4 3.7 5.4 3.0 4.9 -3.7 3.5
Blood White Count 15.5 114.0 141.6 9.1 11.9 9.4 11.1 10.7 -11.3 11.0
Heel T-Score 0.9 7.5 23.9 4.9 2.0 3.0 -2.3 0.1 -2.5 2.1
BMI 19.7 116.9 141.6 7.8 10.0 11.4 11.7 10.7 -11.6 11.9
Height 10.3 203.6 256.0 -13.7 -16.0 -11.3 -14.4 -12.5 15.8 -15.5
Waist Hip Ratio (WHR) 0.4 2.0 5.5 -0.8 -2.3 0.4 -1.7 -1.1 1.5 -1.3
Systolic Blood Pressure 10.4 52.8 112.4 -6.5 -5.6 -10.6 -3.6 -6.7 8.0 -7.8
Smoking Status 6.0 14.4 20.8 -1.7 -4.3 -3.6 -4.6 -3.8 4.0 -3.9
Allergy or Eczema 0.5 1.3 3.1 -0.3 -1.2 -1.8 -0.9 -1.2 1.0 -0.9
Cardiovascular Disease 0.6 2.0 8.5 -0.3 0.5 -2.9 1.8 -1.2 0.4 -0.1
Hypothyroidism (self reported) 7.2 16.7 25.0 1.8 3.5 4.8 4.0 5.0 -4.3 4.3
Respiratory disease 0.5 1.1 3.2 -1.8 -1.1 -1.0 0.0 -0.5 1.1 -1.0
Type 2 Diabetes (T2D) 4.2 8.0 10.7 2.7 2.0 2.9 2.4 3.3 -3.1 3.2
Lung FEV1/FVC ratio 0.0 0.2 0.8 0.9 0.1 -0.2 -0.6 0.1 0.4 -0.4
Lung FVC 0.9 4.5 7.2 -1.3 -1.7 -2.3 -2.7 -2.4 2.1 -2.3
Neuroticism 13.9 34.1 46.9 -5.7 -5.8 -6.8 -4.5 -5.2 6.3 -6.2
Chronotype (morning person) 3.6 8.4 18.2 1.2 2.4 2.6 4.3 2.2 -3.1 3.4
Hair Pigment 0.3 8.6 25.1 1.1 -2.8 -2.2 -5.0 -2.4 2.7 -2.9
Tanning 1.2 15.9 25.4 -3.0 -3.3 -4.9 -3.2 -5.0 4.0 -4.0
Hand grip strength (left) 13.7 36.4 44.5 6.7 5.5 6.0 5.7 5.6 -6.2 6.4
Number of treatments/medications taken 0.4 0.8 2.2 -1.2 -0.6 -0.2 -1.5 -0.5 0.7 -0.9
Average weekly spirits intake 1.0 1.3 2.2 0.1 -1.2 -1.5 -1.0 -1.3 1.1 -1.1
Sensitivity / hurt feelings 0.5 0.9 1.5 0.7 0.9 1.2 0.2 0.9 -1.1 1.0
Frequency of depressed mood in last 2 weeks 12.2 17.2 24.3 3.3 4.3 4.9 3.9 3.5 -4.5 4.4
Hearing difficulty/problems: Yes 0.1 0.2 0.7 0.9 -0.6 0.1 -0.3 0.3 0.2 -0.0
Relative age of first facial hair 1.5 3.2 3.9 1.2 1.7 1.9 1.8 1.8 -2.0 2.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.2 1.1 0.6 -0.2 0.1 0.0 -0.5 0.5
Ever used hormone-replacement therapy (HRT) 10.5 13.4 16.0 -2.1 -3.9 -4.0 -4.0 -3.7 3.8 -3.8
Ever had hysterectomy (womb removed) 4.9 5.5 7.2 -1.4 -2.5 -2.2 -2.5 -2.7 2.4 -2.4
Systolic blood pressure, automated reading 1.7 5.2 13.3 2.7 1.1 3.6 -0.3 1.8 -2.3 2.3
Eye problems/disorders: Diabetes related eye disease 8.9 9.7 10.8 -2.7 -3.1 -3.3 -3.1 -3.3 3.1 -3.2
Angina 2.2 2.8 6.4 -2.5 -1.6 -0.8 -1.3 -1.9 1.5 -1.6
Medication for hormone replacement therapy 0.4 0.5 1.2 -0.5 -0.9 -1.1 -0.2 0.2 0.7 -0.7
Vitamin and mineral supplements 0.8 1.1 2.5 0.6 0.8 1.6 0.9 0.8 -1.2 1.2
Supplements: Zinc 1.2 1.3 2.2 1.4 1.0 0.8 1.0 1.5 -1.0 1.1
Medication: Co-codamol 0.2 0.2 0.5 -0.0 -0.5 -0.1 -0.2 -0.5 0.6 -0.7
Medication: Metformin 8.3 11.7 17.0 -1.7 -2.5 -4.1 -3.3 -4.1 3.6 -3.9
Diabetes (father) 4.5 5.6 8.3 -1.8 -1.8 -2.4 -2.9 -2.6 2.4 -2.5
Diabetes (mother) 0.2 0.2 0.7 -0.3 0.5 0.1 0.9 -0.4 -0.4 0.3
Severe depression (siblings) 5.8 6.5 9.9 2.4 2.5 2.3 2.2 3.1 -2.5 2.6
Pack years adult smoking proportion 2.5 3.8 5.7 1.1 2.0 2.2 1.9 2.4 -2.0 1.9
Impedance of leg (right) 2.8 13.6 26.0 1.1 2.9 5.1 4.2 3.6 -3.8 3.9
Leg fat-free mass (left) 0.3 1.4 4.3 1.8 0.9 -2.1 -0.7 -0.7 0.2 -0.4
Trunk fat percentage 23.2 95.1 112.4 -8.4 -8.7 -10.2 -10.3 -9.5 10.3 -10.6
Hand grip strength (right) 8.8 24.0 31.7 5.6 4.6 5.0 4.4 4.5 -5.0 5.1
Townsend deprivation index at recruitment 9.9 14.0 17.9 2.7 3.7 4.0 3.4 4.2 -4.0 3.9
Current tobacco smoking 12.2 19.9 23.7 3.4 4.5 4.7 4.5 4.2 -4.9 4.9
Average weekly fortified wine intake 0.2 0.2 0.6 0.5 0.0 -0.5 -0.1 -0.8 -0.3 0.4
Maternal smoking around birth 0.5 0.8 2.8 0.5 -0.9 -0.2 -1.7 0.1 0.7 -0.9
Fed-up feelings 5.0 9.2 16.1 3.6 2.8 4.0 1.8 2.3 -3.2 3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 7.2 9.7 11.8 2.6 3.4 3.4 2.8 2.9 -3.3 3.3
Relative age voice broke 0.7 1.2 1.9 0.1 1.1 1.3 1.4 0.9 -1.1 1.2
Taking other prescription medications 3.0 4.6 6.5 -1.9 -1.6 -2.2 -2.4 -2.5 2.0 -2.2
Age when periods started (menarche) 11.1 26.8 33.1 3.7 5.5 5.4 5.8 4.7 -5.3 5.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.7 0.4 -0.5 -0.2 -0.8 -0.3 0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 4.7 -2.2 -0.5 -1.4 1.0 0.4 0.9 -0.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.2 0.2 0.5 1.5 0.5 0.8 -0.9 0.9
Qualifications: CSEs or equivalent 0.8 1.1 1.7 1.2 1.3 1.2 0.9 0.5 -1.0 1.0
Serious illness, injury or assault to yourself 0.8 1.0 2.1 -1.5 -1.0 -0.4 -0.8 -1.0 1.0 -1.1
High blood pressure 0.9 2.5 9.5 0.4 -1.4 3.1 -2.3 0.7 -0.1 -0.2
Hayfever, allergic rhinitis or eczema 1.1 2.3 5.3 0.4 1.4 2.3 1.4 1.7 -1.5 1.4
Multivitamins +/- minerals 0.1 0.2 1.0 1.0 0.3 -0.3 -0.0 0.3 -0.0 0.1
Stomach or abdominal pain in last month 5.1 6.4 9.4 2.2 2.5 3.1 2.5 2.7 -2.4 2.3
Supplements: Glucosamine 1.2 1.6 3.7 0.1 -1.2 -1.9 -1.0 -0.8 1.5 -1.4
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 2.2 -1.4 -1.0 -1.5 -0.8 -1.5 1.1 -1.1
Medication: Atenolol 0.3 0.4 0.8 0.4 -0.8 0.8 -0.4 0.9 0.3 -0.3
Medication: Levothyroxine sodium 6.1 10.3 15.0 -1.8 -3.1 -3.2 -3.2 -3.9 3.5 -3.4
Sitting height 13.5 97.1 110.2 9.6 10.5 9.5 9.3 9.1 -10.5 10.4
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 0.1 0.3 -0.1 -0.1 0.6 -0.2 0.1
High blood pressure (mother) 1.1 1.5 4.0 1.3 0.7 2.0 0.2 1.4 -1.2 1.1
Body mass index (BMI) 18.6 81.3 97.4 -6.8 -8.4 -9.4 -9.6 -9.0 9.6 -9.9
Impedance of leg (left) 2.3 11.1 23.0 0.7 2.7 4.8 3.7 3.3 -3.4 3.4
Leg predicted mass (left) 0.3 1.4 4.7 1.7 0.8 -2.2 -0.8 -0.8 0.2 -0.5
Trunk fat mass 13.0 57.4 69.9 -6.0 -6.3 -8.4 -8.1 -7.6 7.9 -8.3
Waist circumference 11.2 42.0 56.7 -4.9 -5.2 -7.5 -6.8 -6.9 6.7 -7.0
Number of incorrect matches in round 3.6 6.0 9.5 -1.9 -2.3 -3.1 -1.7 -2.3 2.9 -2.8
Past tobacco smoking 1.6 2.9 4.0 -1.6 -2.0 -1.4 -1.8 -1.5 1.8 -1.8
Alcohol usually taken with meals 0.6 1.0 2.7 -0.8 -0.8 -0.8 -0.7 -1.6 1.1 -1.0
Nervous feelings 7.5 14.2 24.6 2.4 3.9 5.0 3.1 3.8 -4.0 3.9
Frequency of tenseness / restlessness in last 2 weeks 8.2 12.9 18.4 2.7 3.7 4.3 3.2 3.3 -3.9 3.8
Hearing difficulty/problems with background noise 1.8 2.9 7.3 2.7 0.8 2.2 0.6 1.3 -1.6 1.7
Hair/balding pattern: Pattern 2 4.2 5.4 7.5 1.6 2.3 2.6 2.1 2.7 -2.4 2.4
Had menopause 0.1 0.1 0.4 0.6 -0.1 -0.4 0.3 0.1 -0.1 0.1
Had other major operations 0.5 0.6 1.4 -1.2 -0.5 -0.8 -0.3 -1.0 0.7 -0.7
Forced vital capacity (FVC) 9.2 36.3 44.0 5.7 6.4 5.0 6.6 5.6 -6.3 6.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.8 -2.2 -0.4 -1.5 1.2 0.5 0.8 -0.7
Ever unenthusiastic/disinterested for a whole week 2.6 3.1 4.3 2.0 1.8 1.4 1.6 1.5 -2.1 1.9
Qualifications: None of the above 0.2 0.4 1.1 1.1 0.3 0.8 -0.4 0.6 -0.3 0.3
Financial difficulties in last 2 years 4.6 6.2 7.9 2.8 2.1 2.8 2.1 2.3 -2.6 2.6
Mouth/teeth dental problems 0.2 0.3 0.7 0.7 0.2 -0.8 0.1 -0.4 -0.5 0.5
Heart attack 0.1 0.1 0.5 0.4 0.7 0.2 0.2 0.1 -0.4 0.3
Allergy 0.8 1.7 3.7 -0.5 -1.2 -1.9 -1.0 -1.4 1.4 -1.2
Pain all over the body in last month 2.1 2.2 3.1 -0.2 -1.8 -1.7 -1.5 -1.6 1.5 -1.6
Diabetes (self-reported) 2.7 4.2 6.7 -2.0 -1.6 -2.3 -1.4 -2.6 2.0 -2.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.4 0.0 -0.9 -0.4 -0.8 -1.2 0.7 -0.7
Medication: Ramipril 1.9 2.5 7.0 0.8 1.2 2.6 0.4 1.8 -1.7 1.5
Medication: Simvastatin 1.2 1.8 2.4 -1.1 -1.4 -1.3 -1.6 -1.4 1.2 -1.3
Fluid intelligence score 12.1 25.5 32.3 3.4 5.6 4.9 5.7 4.8 -5.3 5.3
Illnesses of siblings 1.9 2.7 5.5 0.9 1.8 0.7 2.3 0.9 -1.9 2.0
Neuroticism score 16.3 34.7 48.6 5.6 5.9 7.0 4.9 5.3 -6.2 6.1
Weight 2.1 10.7 20.0 -1.3 -1.9 -4.5 -3.7 -3.6 3.2 -3.5
Impedance of arm (right) 0.5 2.6 6.7 -2.6 -1.6 -1.3 -1.4 -0.7 1.4 -1.5
Arm fat percentage (right) 29.8 120.5 144.0 -9.2 -10.2 -11.4 -11.6 -10.5 11.7 -12.0
Trunk fat-free mass 5.7 33.0 45.4 6.6 6.7 3.9 5.6 4.8 -6.0 5.9
Hip circumference 8.6 38.2 50.0 -3.9 -5.2 -6.6 -7.1 -6.8 6.4 -6.6
Time employed in main current job 0.4 0.4 1.1 -1.0 0.8 0.4 0.6 0.7 -0.3 0.3
Alcohol intake versus 10 years previously 5.3 7.9 10.1 -2.5 -2.4 -3.2 -2.7 -2.5 3.2 -3.1
Father’s age at death 0.7 0.9 2.0 -0.7 -1.1 -1.0 -0.8 -1.4 0.8 -0.7
Worrier / anxious feelings 3.7 7.1 11.1 1.8 2.6 3.3 2.1 3.0 -2.8 2.8
Frequency of tiredness / lethargy in last 2 weeks 9.6 15.7 21.5 4.6 4.4 3.8 2.8 3.2 -4.3 4.2
Falls in the last year 3.8 5.2 7.9 2.0 1.7 2.8 1.4 2.7 -2.5 2.3
Hair/balding pattern: Pattern 3 2.9 4.4 8.1 -0.8 -2.2 -1.9 -2.8 -1.9 2.2 -2.2
Number of live births 0.3 0.4 1.1 0.2 -1.1 -0.3 -0.9 -0.2 0.6 -0.5
Forced expiratory volume in 1-second (FEV1) 6.3 21.8 28.1 4.1 4.9 4.0 5.3 4.3 -5.0 5.0
Pulse rate 0.2 0.3 1.2 -0.4 0.3 -1.1 0.0 -0.8 -0.1 -0.0
Happiness 0.7 0.8 1.2 0.8 1.1 0.7 0.8 0.8 -1.1 1.0
Noisy workplace 0.2 0.3 0.6 0.8 -0.4 0.2 -0.8 0.8 0.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.0 0.0 0.6 -0.2 1.0 0.1 -0.5 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.6 0.7 1.2 1.6 1.0 1.2 -1.1 1.1
Mouth/teeth dental problems: Dentures 0.4 0.7 2.1 0.5 0.9 0.7 1.4 0.7 -0.7 0.8
Asthma 0.3 0.5 1.2 0.9 0.6 1.1 -0.3 0.2 -0.8 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.4 -1.6 -0.6 -0.2 -0.1 -0.3 0.4 -0.3
Medication: Cholesterol lowering 0.1 0.2 0.9 -0.3 -0.4 -0.4 -0.9 -0.3 0.1 -0.3
Depression (self-reported) 4.5 5.4 8.8 1.7 3.0 2.0 1.8 2.0 -2.8 2.6
Medication: Lansoprazole 0.2 0.2 0.9 -1.0 -0.4 0.0 -0.2 -0.5 0.1 -0.3
Prospective memory result 1.4 1.7 4.9 0.3 -1.6 -0.9 -2.2 -0.3 1.2 -1.3
Lung cancer (father) 9.9 11.6 14.6 2.6 3.1 3.5 3.8 3.7 -3.5 3.5
Illnesses of mother 2.3 2.8 6.2 -1.1 -1.2 -2.5 -1.3 -2.0 1.6 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 7.7 25.0 32.8 3.8 5.1 4.2 5.7 4.8 -5.4 5.5
Pulse wave Arterial Stiffness index 0.7 0.8 1.7 -0.1 -0.7 -1.1 -1.3 -0.9 0.7 -0.8
Impedance of arm (left) 0.8 3.9 7.4 -2.7 -2.0 -1.9 -2.0 -1.4 1.7 -1.9
Arm fat mass (right) 15.7 66.4 80.1 -6.0 -7.2 -8.9 -8.8 -8.1 8.6 -8.9
Trunk predicted mass 5.5 32.0 44.1 6.6 6.6 3.8 5.5 4.7 -5.9 5.8
Standing height 13.3 135.2 169.0 11.2 13.0 9.6 11.6 10.4 -12.7 12.5
Length of working week for main job 0.1 0.1 0.3 -0.1 -0.2 0.2 0.2 0.6 -0.2 0.2
Exposure to tobacco smoke at home 0.7 0.8 2.1 0.0 -1.1 -0.2 -1.5 -0.2 0.9 -1.0
Breastfed as a baby 9.4 11.6 16.7 2.0 3.7 2.9 4.1 3.6 -3.6 3.6
Tense / ‘highly strung’ 2.2 3.7 10.1 1.1 1.6 3.2 1.4 1.9 -1.9 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 8.6 13.2 15.5 3.3 3.8 3.8 2.8 3.9 -3.9 3.9
Hair/balding pattern: Pattern 4 3.2 7.9 11.9 -2.5 -2.9 -2.9 -2.7 -3.5 2.6 -2.6
Birth weight of first child 0.3 0.6 1.8 0.7 1.2 -0.2 1.3 0.1 -0.6 0.6
Peak expiratory flow (PEF) 5.9 13.8 19.0 2.8 3.8 3.3 4.4 3.8 -3.8 3.9
Pulse wave reflection index 2.0 2.4 4.0 -0.1 -1.9 -1.3 -2.0 -1.3 1.8 -1.7
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.3 1.0 1.1 0.5 0.7 0.2 -1.1 1.0
Loud music exposure frequency 7.8 8.5 12.0 -2.0 -2.8 -2.5 -3.3 -2.6 3.4 -3.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.8 -0.7 0.6 -0.6 0.5 -0.9 -0.1 0.0
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.4 -1.6 -0.9 0.7 -1.2 0.2 1.0 -1.2
Blood clot in the leg (DVT) 1.7 2.1 4.0 1.8 1.3 0.9 2.0 1.2 -1.4 1.3
Medication: Paracetamol 1.3 2.2 4.2 -2.0 -1.5 -1.3 -1.3 -1.4 1.4 -1.4
Headache pain in last month 0.4 0.7 1.6 -1.3 0.7 1.1 0.7 0.8 -0.6 0.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 1.5 -0.4 -0.1 -1.2 0.6 -0.7 0.6 -0.4
Glaucoma (self-reported) 4.8 5.6 9.4 0.9 3.0 1.8 3.1 2.1 -2.5 2.4
Gout (self-reported) 0.9 1.2 1.9 1.4 1.2 1.2 0.6 1.0 -1.1 1.1
Hypothyroidism/myxoedema (self-reported) 5.0 9.8 14.9 -1.6 -2.8 -3.2 -3.2 -3.9 3.4 -3.3
Medication: Amlodipine 0.5 0.6 2.2 0.6 0.0 1.5 -0.8 1.1 -0.3 0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.2 1.0 1.0 0.3 0.4 -0.3 0.1 -0.4 0.3
Birth weight 9.2 19.9 23.7 3.9 4.6 4.1 4.7 4.2 -4.9 4.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 0.6 0.1 0.2 0.3 0.1 -0.3 0.3
High blood pressure (siblings) 0.7 1.0 2.2 0.4 -1.4 0.9 -1.5 0.2 1.0 -1.0
Forced vital capacity (FVC), Best measure 11.7 43.9 52.7 5.5 6.8 5.7 7.3 6.6 -7.0 7.2
Body fat percentage 24.6 99.5 121.0 -8.5 -9.1 -10.1 -10.5 -9.8 10.6 -11.0
Leg fat percentage (right) 19.8 73.2 89.1 -7.6 -8.2 -8.1 -8.9 -8.4 9.2 -9.4
Arm fat-free mass (right) 2.5 13.1 22.5 4.7 4.5 2.1 3.3 2.5 -3.8 3.6
Exposure to tobacco smoke outside home 0.1 0.2 0.7 -0.2 0.1 0.4 -0.8 -0.5 0.3 -0.4
Comparative body size at age 10 18.0 50.6 62.2 -5.2 -6.5 -7.9 -7.4 -7.0 7.5 -7.8
Number of full brothers 1.0 1.2 3.6 0.8 0.1 1.3 0.4 1.9 -1.0 1.1
Worry too long after embarrassment 3.9 6.6 9.0 3.0 2.6 2.6 1.9 2.1 -2.8 2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 3.1 4.1 5.1 0.8 2.3 2.1 2.1 2.1 -2.2 2.2
Wheeze or whistling in the chest in last year 0.2 0.3 1.2 1.1 0.5 0.7 -0.2 -0.1 -0.4 0.3
Number of children fathered 1.8 2.1 3.5 -1.8 -1.9 -1.3 -1.0 -0.8 1.5 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.3 1.1 0.5 0.3 0.2 0.5 -0.5 0.5
Age at first live birth 1.0 1.9 3.7 -1.0 -1.2 -1.9 -0.9 -1.8 1.3 -1.1
Pulse wave peak to peak time 2.5 3.0 4.9 1.0 1.7 1.9 2.2 1.7 -1.7 1.7
Health satisfaction 3.2 4.1 6.9 1.5 2.0 2.6 1.3 2.2 -2.2 2.0
Shortness of breath walking on level ground 0.2 0.3 0.7 0.7 0.3 0.9 -0.3 0.4 -0.6 0.4
Qualifications: College or University degree 0.4 1.3 2.4 -1.6 -1.4 -1.2 -0.9 -1.2 0.8 -0.7
Eye problems/disorders: None of the above 4.3 5.0 6.9 1.6 2.2 2.6 2.0 2.1 -2.4 2.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.0 0.2 0.4 1.0 0.1 0.5 -0.1 0.1
Emphysema/chronic bronchitis 0.6 0.7 1.7 0.4 1.3 0.6 0.1 0.9 -1.0 0.8
Medication for pain relief, constipation, heartburn 1.8 3.1 8.1 2.8 1.7 0.9 1.6 1.1 -1.8 1.8
Neck or shoulder pain in last month 0.9 1.3 1.8 1.1 1.3 1.2 0.8 0.8 -1.3 1.3
Medication: Blood pressure 1.0 1.8 7.3 1.1 0.3 2.7 -0.4 1.3 -1.1 1.0
Angina (self-reported) 2.4 3.1 7.2 -2.7 -1.7 -0.9 -1.3 -2.0 1.6 -1.7
Migraine (self-reported) 4.2 5.3 7.3 0.7 2.2 2.3 2.7 2.3 -2.5 2.7
Medication: Ibuprofen 0.3 0.4 1.4 -1.2 -0.6 -0.4 -0.1 -0.3 0.7 -0.6
Medication: Allopurinol 1.0 1.4 3.2 1.8 0.8 1.3 -0.0 1.0 -1.2 1.3
Medication: Omeprazole 1.1 1.4 2.8 -1.7 -0.8 -1.1 -0.8 -0.8 1.4 -1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.5 0.6 0.4 0.1 -0.3 0.7 -0.4 0.2
Mean time to correctly identify matches 0.4 0.8 2.9 -1.1 0.3 -0.8 0.5 1.7 0.4 -0.3
Heart disease (mother) 0.3 0.4 0.9 -0.6 -1.0 0.3 -0.6 0.8 0.5 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.3 -1.3 -0.9 -0.4 -1.2 -1.8 0.7 -0.7
Whole body fat mass 13.3 57.1 69.2 -5.9 -6.5 -8.2 -8.1 -7.6 8.0 -8.3
Leg fat mass (right) 12.6 50.1 61.2 -5.5 -6.4 -7.3 -7.5 -7.1 7.5 -7.8
Arm predicted mass (right) 2.2 11.6 21.5 4.6 4.2 1.8 3.1 2.4 -3.5 3.3
Pulse rate, automated reading 0.4 1.3 3.5 -1.9 0.5 -1.7 1.1 -1.0 -0.1 0.0
Alcohol intake frequency. 13.5 31.9 37.7 -5.6 -5.3 -6.0 -4.8 -5.7 6.0 -6.1
Comparative height size at age 10 5.5 30.9 40.9 5.9 6.4 3.8 5.5 4.8 -6.1 6.0
Number of full sisters 0.3 0.4 0.8 0.7 0.2 0.9 0.1 0.9 -0.4 0.4
Suffer from ‘nerves’ 33.1 52.6 61.8 5.4 7.8 7.9 7.4 6.2 -7.9 7.8
Overall health rating 1.1 2.4 4.7 2.2 1.5 1.7 0.5 1.1 -1.7 1.6
Chest pain or discomfort 6.7 9.7 12.4 2.4 3.1 3.5 3.0 3.2 -3.3 3.1
Had major operations 0.7 0.9 1.4 0.4 0.9 1.1 0.7 0.7 -1.2 1.2
Age at last live birth 1.2 1.7 3.6 0.8 1.3 1.1 1.9 0.8 -1.4 1.5
Family relationship satisfaction 3.4 4.1 5.2 1.9 2.3 2.0 1.8 2.1 -2.1 2.0
Leg pain on walking 1.4 1.8 3.8 1.1 0.9 1.9 0.7 1.6 -1.4 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.2 -1.1 -0.0 -0.1 0.8 0.0 0.2 -0.4
Commuting to job workplace: Car/motor vehicle 1.2 1.4 5.3 -2.3 -0.8 -0.9 0.0 -0.8 1.1 -1.1
Illness, injury, bereavement, stress in last 2 years 6.2 7.5 12.2 -1.7 -2.6 -3.5 -2.7 -2.8 2.8 -2.8
Medication: Aspirin 0.1 0.2 0.5 -0.4 -0.5 0.2 -0.7 -0.2 0.3 -0.3
Supplements: Vitamin C 0.7 0.8 3.9 -2.0 -0.6 -0.5 -0.2 -0.8 0.7 -0.6
Knee pain experienced in last month 4.6 7.1 11.4 0.8 3.4 2.5 3.0 2.7 -2.8 2.7
Hypertension (Self-reported) 0.9 2.5 10.0 0.4 -1.3 3.2 -2.2 0.7 -0.1 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 5.7 6.7 9.5 2.2 2.6 2.3 2.5 3.1 -2.6 2.7
Illnesses of father: Heart disease 0.4 0.6 2.1 1.4 0.4 0.2 -0.6 1.1 -0.5 0.4
Illnesses of siblings: Diabetes 6.7 8.3 10.2 -2.4 -2.6 -3.0 -3.2 -2.9 3.0 -3.1
Smoking status: Previous 0.1 0.1 0.3 0.4 0.5 -0.3 0.2 0.0 -0.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted 8.3 17.4 22.4 3.1 4.6 3.5 4.6 3.6 -4.7 4.7
Whole body fat-free mass 2.1 12.1 23.4 4.8 4.4 1.5 3.0 2.5 -3.5 3.4
Leg fat-free mass (right) 0.3 1.4 4.3 2.1 1.1 -1.9 -0.6 -0.6 -0.1 -0.1
Arm fat percentage (left) 32.1 131.2 156.2 -9.5 -10.6 -11.9 -12.1 -11.1 12.2 -12.5
Average weekly red wine intake 0.7 1.1 1.6 1.0 0.7 0.9 1.1 1.0 -1.1 1.3
Handedness (chirality/laterality): Left-handed 3.1 3.8 4.3 2.1 2.0 1.9 1.5 2.0 -2.0 2.0
Mood swings 11.2 20.6 39.0 3.6 4.2 6.2 3.6 4.3 -4.7 4.6
Loneliness, isolation 26.4 36.4 41.9 5.4 6.4 6.5 5.3 5.9 -6.4 6.2
Long-standing illness, disability or infirmity 0.0 0.0 0.1 0.1 0.3 0.1 -0.1 0.3 -0.2 0.1
Ever had bowel cancer screening 1.9 2.2 3.0 -1.6 -1.6 -1.7 -1.1 -0.9 1.6 -1.6
Diabetes diagnosed by doctor 3.0 5.0 7.9 -1.9 -1.5 -2.7 -1.6 -2.8 2.3 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.2 0.3 1.0 1.1 1.5 1.1 -0.8 0.9
Friendships satisfaction 4.4 5.4 6.8 1.3 2.5 2.3 2.6 2.2 -2.5 2.5
Qualifications: nursing, teaching 1.5 2.4 3.7 -0.9 -1.7 -1.9 -1.9 -1.2 1.6 -1.5
Commuting to job workplace: Walk 1.7 1.8 3.1 1.8 1.1 1.5 0.5 1.3 -1.5 1.4
Eye problems/disorders: Cataract 5.4 6.3 9.5 -1.3 -2.6 -3.1 -2.2 -2.8 2.6 -2.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.9 0.7 -1.0 0.3 -0.9 0.8 0.4 -0.4
Medication for cholesterol 1.5 2.3 5.0 1.2 2.0 0.6 2.2 0.4 -1.6 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 2.8 -1.4 -1.2 -1.1 -1.6 -0.6 1.6 -1.7
Back pain experienced in last month 1.1 1.7 3.4 1.4 1.2 1.8 0.7 0.9 -1.3 1.3
Mineral and other dietary supplements 2.9 3.9 5.1 0.8 2.1 2.2 2.1 1.7 -2.3 2.2
Breast cancer (self-reported) 0.7 0.8 1.2 -0.5 -0.8 -1.0 -1.0 -1.1 0.9 -0.9
Asthma (self-reported) 0.3 0.6 1.2 1.1 0.7 1.1 -0.3 0.2 -0.9 0.8
Osteoporosis (self-reported) 0.4 0.5 2.7 1.6 0.5 0.2 -0.2 -0.1 -0.5 0.5
Osteoarthritis (self-reported) 1.9 2.4 4.2 1.9 2.1 1.0 1.3 1.2 -1.6 1.6
Medication: Aspirin 0.1 0.1 0.4 -0.4 -0.4 -0.0 -0.6 -0.1 0.3 -0.3
Medication: Gliclazide 2.9 3.3 5.2 -1.0 -1.6 -2.3 -1.7 -2.1 1.9 -2.0
Illnesses of father: None of the above (group 1) 0.4 0.5 2.3 -0.7 0.5 0.4 1.5 0.2 -0.5 0.5
Smoking status: Current 12.6 19.9 23.8 3.3 4.6 4.7 4.5 4.2 -4.9 4.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.7 -0.7 -0.8 -0.8 -0.4 -0.3 0.9 -0.6
Whole body water mass 2.2 12.6 24.2 4.9 4.5 1.5 3.1 2.6 -3.6 3.5
Leg predicted mass (right) 0.3 1.4 4.0 2.0 1.1 -1.9 -0.6 -0.6 -0.1 -0.2
Arm fat mass (left) 16.0 67.3 81.2 -6.2 -7.2 -9.0 -8.7 -8.2 8.7 -9.0
Number of self-reported non-cancer illnesses 1.2 2.2 4.5 1.6 1.1 2.1 0.2 1.0 -1.7 1.6
Average weekly champagne plus white wine intake 3.5 4.8 7.9 0.8 2.5 2.8 2.5 2.1 -2.0 2.0
Miserableness 16.2 28.6 45.7 5.0 5.2 6.8 4.5 4.4 -5.7 5.5
Guilty feelings 9.1 13.8 20.0 4.1 3.4 4.5 2.5 3.3 -3.9 3.9
Wears glasses or contact lenses 0.1 0.1 0.5 -0.7 0.3 -0.4 0.1 0.2 0.2 -0.3
Ever taken oral contraceptive pill 5.5 6.1 8.3 1.8 2.6 2.2 2.8 1.9 -2.8 2.9
Hearing aid user 5.6 6.4 7.8 -2.3 -2.2 -2.1 -2.6 -2.7 2.7 -2.8
Mother’s age at death 0.0 0.0 0.1 -0.2 0.1 0.3 0.2 0.1 -0.1 0.2
Financial situation satisfaction 3.4 4.2 5.4 1.8 2.3 1.9 2.1 1.8 -2.2 2.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.3 1.1 0.2 0.8 0.7 0.9 -0.3 0.4
Commuting to job workplace: Public transport 0.5 0.6 1.0 1.0 0.8 0.6 0.0 0.7 -0.9 0.9
Eye problems/disorders: Glaucoma 5.8 6.9 13.8 1.0 3.4 1.6 3.7 2.5 -2.6 2.5
Medication: Blood pressure 1.2 2.3 6.8 -0.8 -2.1 0.7 -2.6 -0.3 1.3 -1.4
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.4 0.5 0.5 0.5 0.3 0.7 -0.7 0.6
Supplements: Fish oil (including cod liver oil) 4.2 5.5 8.0 -1.7 -2.2 -2.8 -2.4 -1.8 2.7 -2.6
High cholesterol (Self-reported) 0.1 0.2 0.6 -0.4 -0.5 -0.1 -0.8 -0.2 0.4 -0.5
Medication: Bendroflumethiazide 1.4 2.2 7.9 1.5 0.7 2.8 -0.3 1.3 -1.2 1.2
Medication: Paracetamol 1.4 2.2 2.8 -1.7 -1.5 -1.6 -1.3 -1.4 1.5 -1.5
Medication: Lisinopril 0.3 0.4 1.6 0.7 -0.3 1.3 -0.8 0.1 -0.1 -0.0
Medication: Atorvastatin 0.1 0.1 0.4 -0.7 0.5 -0.2 -0.1 0.1 -0.1 -0.0
Illnesses of father: High blood pressure 2.3 2.9 10.1 1.2 0.5 3.2 0.6 2.2 -1.3 1.3
Alcohol drinker status: Never 10.8 12.9 14.5 -3.8 -3.5 -3.5 -3.1 -3.5 3.8 -3.8
Ever smoked 3.7 6.6 8.0 1.9 2.6 2.6 2.8 2.4 -2.7 2.8
Basal metabolic rate 0.7 3.8 10.5 3.2 2.8 -0.1 1.3 0.9 -1.8 1.6
Leg fat percentage (left) 21.9 80.6 98.1 -8.0 -8.5 -8.5 -9.4 -8.8 9.6 -9.9
Arm fat-free mass (left) 2.2 11.1 20.2 4.5 4.2 1.9 3.0 2.3 -3.4 3.2
Number of operations (self-reported) 2.3 3.5 5.6 -2.4 -1.9 -2.0 -1.4 -1.7 1.9 -1.8
Average weekly beer plus cider intake 7.7 11.1 14.4 3.2 3.1 3.5 3.1 3.8 -3.3 3.3
Irritability 2.4 4.1 6.3 1.5 2.3 2.5 1.8 1.9 -2.1 1.9
Risk taking 0.6 0.8 2.7 1.4 0.2 0.4 0.3 1.6 -0.7 0.8
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.5 0.7 -0.0 -0.6 -0.2 -0.2 0.3 -0.2
Fractured/broken bones in last 5 years 4.4 5.7 8.0 2.4 1.9 2.6 1.7 2.4 -2.7 2.8
Age started oral contraceptive pill 0.7 0.9 1.4 0.1 -1.2 -1.2 -1.1 -0.6 1.0 -0.9
Diastolic blood pressure, automated reading 0.9 2.8 11.5 1.1 0.6 3.4 -0.1 1.1 -1.7 1.6
Ever depressed for a whole week 3.1 3.9 5.5 2.3 2.2 1.5 1.7 1.9 -2.0 2.0
Unable to work because of sickness or disability 3.7 4.8 6.2 1.3 2.3 2.1 1.9 2.5 -2.4 2.5
Commuting to job workplace: Cycle 0.5 0.5 0.9 -0.7 -1.0 -0.8 -0.6 -0.9 0.6 -0.5
Myopia 9.2 13.3 18.8 2.0 3.8 3.4 4.1 4.3 -3.7 3.8
Vascular/heart problems diagnosed by doctor 0.7 2.1 6.3 -0.4 1.4 -2.5 2.4 -0.5 -0.2 0.5
Cholesterol lowering medication 2.8 4.1 5.1 -2.3 -1.8 -1.7 -2.1 -2.1 2.0 -2.2
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 4.6 -2.1 -1.2 -1.2 -1.1 -1.3 1.7 -1.6
Pain experienced in last month 0.6 1.1 2.0 0.2 -1.4 -1.4 -1.1 -0.5 1.0 -1.0
Supplements: Calcium 1.1 1.2 1.7 1.0 1.2 0.7 0.8 1.2 -1.3 1.3
Basal cell carcinoma (self-reported) 2.8 3.3 7.1 -0.3 -2.6 -1.1 -2.7 -1.3 1.9 -1.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.9 0.9 0.4 0.4 0.3 -0.7 0.6
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.5 1.5 1.0 0.6 1.6 1.0 -1.0 1.0
Heart disease (siblings) 0.3 0.3 1.5 -1.2 0.3 -0.3 0.4 0.5 0.3 -0.3
Alcohol drinker status: Previous 0.1 0.1 0.5 0.1 0.7 0.2 0.3 0.3 -0.3 0.1
Pack years of smoking 1.9 2.9 4.4 1.0 1.9 1.7 1.6 2.1 -1.6 1.6
Impedance of whole body 0.2 1.1 2.5 -1.5 0.3 1.6 0.9 0.9 -0.9 0.8
Leg fat mass (left) 13.3 53.5 65.3 -5.7 -6.6 -7.6 -7.8 -7.3 7.8 -8.1
Arm predicted mass (left) 2.1 11.1 20.0 4.5 4.3 1.9 3.0 2.3 -3.4 3.2